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378 results on '"Hettmer, Simone"'

5. Congenital spindle cell rhabdomyosarcoma: An international cooperative analysis

Author

Whittle, Sarah, Venkatramani, Rajkumar, Schönstein, Anton, Pack, Svetlana D., Alaggio, Rita, Vokuhl, Christian, Rudzinski, Erin R., Wulf, Anna–Lena, Zin, Angelica, Gruver, Juliana R., Arnold, Michael A., Merks, Johannes H.M., Hettmer, Simone, Koscielniak, Ewa, Barr, Frederic G., Hawkins, Douglas S., Bisogno, Gianni, and Sparber-Sauer, Monika

Published
2022
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6. Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry

Author

Penkert, Judith, Strüwe, Farina J., Dutzmann, Christina M., Doergeloh, Beate B., Montellier, Emilie, Freycon, Claire, Keymling, Myriam, Schlemmer, Heinz-Peter, Sänger, Birte, Hoffmann, Beatrice, Gerasimov, Tanja, Blattmann, Claudia, Fetscher, Sebastian, Frühwald, Michael, Hettmer, Simone, Kordes, Uwe, Ridola, Vita, Kroiss Benninger, Sabine, Mastronuzzi, Angela, Schott, Sarah, Nees, Juliane, Prokop, Aram, Redlich, Antje, Seidel, Markus G., Zimmermann, Stefanie, Pajtler, Kristian W., Pfister, Stefan M., Hainaut, Pierre, and Kratz, Christian P.

Published
2022
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7. Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report

Author

Drude, Natascha Ingrid, Martinez-Gamboa, Lorena, Danziger, Meggie, Collazo, Anja, Kniffert, Silke, Wiebach, Janine, Nilsonne, Gustav, Konietschke, Frank, Piper, Sophie K., Pawel, Samuel, Micheloud, Charlotte, Held, Leonhard, Frommlet, Florian, Segelcke, Daniel, Pogatzki-Zahn, Esther M., Voelkl, Bernhard, Friede, Tim, Brunner, Edgar, Dempfle, Astrid, Haller, Bernhard, Jung, Marie Juliane, Riecken, Lars Björn, Kuhn, Hans-Georg, Tenbusch, Matthias, Higuita, Lina Maria Serna, Remarque, Edmond J., Grüninger-Egli, Servan Luciano, Manske, Katrin, Kobold, Sebastian, Rivalan, Marion, Wedekind, Lisa, Wilcke, Juliane C., Boulesteix, Anne-Laure, Meinhardt, Marcus W., Spanagel, Rainer, Hettmer, Simone, von Lüttichau, Irene, Regina, Carla, Dirnagl, Ulrich, and Toelch, Ulf

Published
2022
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10. Genetic testing and surveillance in infantile myofibromatosis: a report from the SIOPE Host Genome Working Group

Author

Hettmer, Simone, Dachy, Guillaume, Seitz, Guido, Agaimy, Abbas, Duncan, Catriona, Jongmans, Marjolijn, Hirsch, Steffen, Kventsel, Iris, Kordes, Uwe, de Krijger, Ronald R., Metzler, Markus, Michaeli, Orli, Nemes, Karolina, Poluha, Anna, Ripperger, Tim, Russo, Alexandra, Smetsers, Stephanie, Sparber-Sauer, Monika, Stutz, Eveline, Bourdeaut, Franck, Kratz, Christian P., and Demoulin, Jean-Baptiste

Published
2021
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12. Diagnostik und Therapie von Tumoren mit NTRK-Genfusionen

Author

Stenzinger, Albrecht, van Tilburg, Cornelis M., Tabatabai, Ghazaleh, Länger, Florian, Graf, Norbert, Griesinger, Frank, Heukamp, Lukas C., Hummel, Michael, Klingebiel, Thomas, Hettmer, Simone, Vokuhl, Christian, Merkelbach-Bruse, Sabine, Overkamp, Friedrich, Reichardt, Peter, Scheer, Monika, Weichert, Wilko, Westphalen, C. Benedikt, Bokemeyer, Carsten, Ivanyi, Philipp, Loges, Sonja, Schirmacher, Peter, Wörmann, Bernhard, Bielack, Stefan, and Seufferlein, Thomas T. W.

Published
2021
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13. Bone marrow disease in rhabdomyosarcoma visualized by 2-[18F]fluorodeoxyglucose positron emission tomography/computed tomography.

Author

Kröning, Pia, Berg, Sebastian, Freitag, Martin T, Schoot, Reineke A, Fischer, Alexandra, Puzik, Alexander, Feuchtinger, T, Niemeyer, Charlotte, Meyer, Philipp Tobias, Uhl, Markus, and Hettmer, Simone

Subjects
POSITRON emission tomography computed tomography, POSITRON emission tomography, BONE marrow diseases, COMPUTED tomography, RHABDOMYOSARCOMA
Abstract

Bone marrow metastases—noted in 6% of patients with rhabdomyosarcoma—have been linked to very poor outcomes. Bilateral bone marrow sampling from iliac crests has been the gold standard for bone marrow examination in rhabdomyosarcoma, but sampling errors due to patchy bone marrow involvement may limit its sensitivity. Here, we report the case of a 6-year-old boy with embryonal rhabdomyosarcoma of the skull base and multiple 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG)-avid bone marrow metastases visualized by positron emission tomography and computed tomography (2-[18F]FDG PET/CT). His bone marrow aspirates were tumor-free. This case illustrates the diagnostic value of 2-[18F]FDG PET/CT in the detection of bone marrow metastases in rhabdomyosarcoma patients, which may re-shape the definition of bone marrow disease and, ultimately, alter disease staging and risk stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Community-driven development of a modified progression-free survival ratio for precision oncology

Author

Mock, Andreas, Heilig, Christoph E, Kreutzfeldt, Simon, Huebschmann, Daniel, Heining, Christoph, Schröck, Evelin, Brors, Benedikt, Stenzinger, Albrecht, Jäger, Dirk, Schlenk, Richard, Glimm, Hanno, Fröhling, Stefan, Horak, Peter, Apostolidis, Leonidas, Augustin, Marinela, Aust, Daniela, Bhatti, Irfan Ahmed, Bloehdorn, Johannes, Brendel, Cornelia, Britschgi, Christian, Braess, Jan, Burdach, Stefan, Busch, Elena, Casuscelli, Jozefina, Desuki, Alexander, Deutsch, Thomas, Dietrich, Mareike, Ehmer, Ursula, Ettrich, Thomas J, Falkenhorst, Johanna, Fehm, Tanja, Flörcken, Anne, Forschner, Andrea, Fuxius, Stefan, Gonzales-Carmona, Maria, Griesinger, Frank, Grill, Sabine, Gröschel, Stefan, Haag, Georg Martin, Haag, Ulrich, Halama, Niels, Hebart, Holger, Heidger, Nina, Hermes, Barbara, Hess, Georg, Hettmer, Simone, Hoechstetter, Manuela, Hoffmann, Martin, Hüttner, Felix J, Illert, Anna L, Jenzer, Maximilian, Kasper, Bernd, Kasper-Virchow, Stefan, Kindler, Thomas, Koscielniak, Ewa, Krönke, Jan, Kühn, Michael, Kunzmann, Volker, Lang, Alois, Leichsenring, Jonas, Livingstone, Elisabeth, Liotta, Lucia, Luley, Kim, Mack, Elisabeth, Martens, Uwe M, Metzeler, Klaus, Middeke, Jan Moritz, Möhrmann, Lino, Jayarama-Naidu, Roopa, Pape, Ulrich-Frank, Perkhofer, Lukas, Pfeufer, Arne, Pixberg, Constantin, Quante, Michael, Rendenbach, Bernhard, Rieke, Damian, Rothermundt, Christian, Sagerer, Andre Norbert, Salzmann, Martin, Saur, Dieter, Schilling, Bastian, Schleicher, Jan, Schlenska-Lange, Anke, Schmidt, Thomas, Schmitz, Sophia, Schölch, Sebastian, Shah, Rajiv, Shoumariyeh, Khalid, Siebenhüner, Alexander, Singh, Martin, Siveke, Jens, Springfeld, Christoph, Starke, Helen, Strobel, Sophia, Teleanu, Veronica, Thon, Niklas, Wagner, Sebastian, Walle, Thomas, Westphalen, Benedikt, Whitlock, Bettina, Winkler, Eva, Wirsik, Naita Maren, Woydack, Lena, Bois, Angelika Zabel-du, and Zschäbitz, Stefanie

Published
2019
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18. Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma

Author

Pomella, Silvia, primary, Danielli, Sara G., additional, Alaggio, Rita, additional, Breunis, Willemijn B., additional, Hamed, Ebrahem, additional, Selfe, Joanna, additional, Wachtel, Marco, additional, Walters, Zoe S., additional, Schäfer, Beat W., additional, Rota, Rossella, additional, Shipley, Janet M., additional, and Hettmer, Simone, additional

Published
2023
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20. Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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21. Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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22. Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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23. Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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24. Data from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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25. Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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26. Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma

Author

Pomella, Silvia; https://orcid.org/0000-0002-7007-4238, Danielli, Sara G; https://orcid.org/0000-0003-3101-3114, Alaggio, Rita, Breunis, Willemijn B, Hamed, Ebrahem, Selfe, Joanna, Wachtel, Marco; https://orcid.org/0000-0002-6077-3692, Walters, Zoe S; https://orcid.org/0000-0002-1835-5868, Schäfer, Beat W; https://orcid.org/0000-0001-5988-2915, Rota, Rossella; https://orcid.org/0000-0002-9408-7711, Shipley, Janet M, Hettmer, Simone; https://orcid.org/0000-0003-1709-4448, Pomella, Silvia; https://orcid.org/0000-0002-7007-4238, Danielli, Sara G; https://orcid.org/0000-0003-3101-3114, Alaggio, Rita, Breunis, Willemijn B, Hamed, Ebrahem, Selfe, Joanna, Wachtel, Marco; https://orcid.org/0000-0002-6077-3692, Walters, Zoe S; https://orcid.org/0000-0002-1835-5868, Schäfer, Beat W; https://orcid.org/0000-0001-5988-2915, Rota, Rossella; https://orcid.org/0000-0002-9408-7711, Shipley, Janet M, and Hettmer, Simone; https://orcid.org/0000-0003-1709-4448

Abstract

Rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children and adolescents, represents an aberrant form of skeletal muscle differentiation. Both skeletal muscle development, as well as regeneration of adult skeletal muscle are governed by members of the myogenic family of regulatory transcription factors (MRFs), which are deployed in a highly controlled, multi-step, bidirectional process. Many aspects of this complex process are deregulated in RMS and contribute to tumorigenesis. Interconnected loops of super-enhancers, called core regulatory circuitries (CRCs), define aberrant muscle differentiation in RMS cells. The transcriptional regulation of MRF expression/activity takes a central role in the CRCs active in skeletal muscle and RMS. In PAX3::FOXO1 fusion-positive (PF+) RMS, CRCs maintain expression of the disease-driving fusion oncogene. Recent single-cell studies have revealed hierarchically organized subsets of cells within the RMS cell pool, which recapitulate developmental myogenesis and appear to drive malignancy. There is a large interest in exploiting the causes of aberrant muscle development in RMS to allow for terminal differentiation as a therapeutic strategy, for example, by interrupting MEK/ERK signaling or by interfering with the epigenetic machinery controlling CRCs. In this review, we provide an overview of the genetic and epigenetic framework of abnormal muscle differentiation in RMS, as it provides insights into fundamental mechanisms of RMS malignancy, its remarkable phenotypic diversity and, ultimately, opportunities for therapeutic intervention.

Published
2023

27. Sarcoma of the Uterus. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/074, April 2021)

Author

Denschlag, Dominik, additional, Ackermann, Sven, additional, Battista, Marco Johannes, additional, Cremer, Wolfgang, additional, Egerer, Gerlinde, additional, Fehr, Matthias, additional, Follmann, Markus, additional, Haase, Heidemarie, additional, Harter, Philipp, additional, Hettmer, Simone, additional, Horn, Lars-Christian, additional, Juhasz-Boess, Ingolf, additional, Kast, Karin, additional, Köhler, Günter, additional, Kröncke, Thomas, additional, Lindel, Katja, additional, Mallmann, Peter, additional, Meyer-Steinacker, Regine, additional, Mustea, Alexander, additional, Petru, Edgar, additional, Reichardt, Peter, additional, Schmidt, Dietmar, additional, Strauss, Hans-Georg, additional, Thiel, Falk, additional, Ulrich, Uwe Andreas, additional, Vogl, Thomas, additional, Vordermark, Dirk, additional, Wallwiener, Markus, additional, Gass, Paul, additional, and Beckmann, Matthias W., additional

Published
2022
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28. Evaluation of functional and metabolic tumor volume using voxel-wise analysis in childhood rhabdomyosarcoma

Author

Maennlin, Simon, primary, Chaika, Maryanna, additional, Gassenmaier, Sebastian, additional, Grimm, Robert, additional, Sparber-Sauer, Monika, additional, Fuchs, Jörg, additional, Schmidt, Andreas, additional, Ebinger, Martin, additional, Hettmer, Simone, additional, Gatidids, Sergios, additional, Dittmann, Helmut, additional, and Schäfer, Jürgen F., additional

Published
2022
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29. Rhabdomyosarcoma xenotransplants in zebrafish embryos

Author

Siebert, Jakob, primary, Schneider, Michaela, additional, Reuter‐Schmitt, Daniela, additional, Würtemberger, Julia, additional, Neubüser, Annette, additional, Driever, Wolfgang, additional, Hettmer, Simone, additional, and Kapp, Friedrich G., additional

Published
2022
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30. Sarcoma of the Uterus. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/074, April 2021)

Author

Denschlag, Dominik, Ackermann, Sven, Battista, Marco Johannes, Cremer, Wolfgang, Egerer, Gerlinde, Fehr, Matthias, Follmann, Markus, Haase, Heidemarie, Harter, Philipp, Hettmer, Simone, Horn, Lars-Christian, Juhasz-Boess, Ingolf, Kast, Karin, Köhler, Günter, Kröncke, Thomas, Lindel, Katja, Mallmann, Peter, Meyer-Steinacker, Regine, Mustea, Alexander, Petru, Edgar, Reichardt, Peter, Schmidt, Dietmar, Strauss, Hans-Georg, Thiel, Falk, Ulrich, Uwe Andreas, Vogl, Thomas, Vordermark, Dirk, Wallwiener, Markus, Gass, Paul, and Beckmann, Matthias W.

Subjects
Maternity and Midwifery, Obstetrics and Gynecology
Abstract

Purpose This is an official guideline, published and coordinated by the Germany Society for Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG). Because of their rarity and heterogeneous histopathology, uterine sarcomas are challenging in terms of their clinical management and therefore require a multidisciplinary approach. To our knowledge, there are currently no binding evidence-based recommendations for the appropriate management of this heterogeneous group of tumors. Methods This S2k guideline was first published in 2015. The update published here is once again the result of the consensus of a representative interdisciplinary committee of experts who were commissioned by the Guidelines Committee of the DGGG to carry out a systematic search of the literature on uterine sarcomas. Members of the participating professional societies achieved a formal consensus after a structured consensus process. Recommendations 1.1 Epidemiology, classification, staging of uterine sarcomas. 1.2 Symptoms, general diagnostic workup, general pathology or genetic predisposition to uterine sarcomas. 2. Management of leiomyosarcomas. 3. Management of low-grade endometrial stromal sarcomas. 4. Management of high-grade endometrial stromal sarcoma and undifferentiated uterine sarcomas. 5. Management of adenosarcomas. 6. Rhabdomyosarcomas of the uterus in children and adolescents. 7. Follow-up of uterine sarcomas. 8. Management of morcellated uterine sarcomas. 9. Information provided to patients.

Published
2022

31. Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe

Author

Hettmer, Simone, primary, Linardic, Corinne M., additional, Kelsey, Anna, additional, Rudzinski, Erin R., additional, Vokuhl, Christian, additional, Selfe, Joanna, additional, Ruhen, Olivia, additional, Shern, Jack F., additional, Khan, Javed, additional, Kovach, Alexander R., additional, Lupo, Philip J., additional, Gatz, Susanne A., additional, Schäfer, Beat W., additional, Volchenboum, Samuel, additional, Minard-Colin, Véronique, additional, Koscielniak, Ewa, additional, Hawkins, Douglas S., additional, Bisogno, Gianni, additional, Sparber-Sauer, Monika, additional, Venkatramani, Rajkumar, additional, Merks, Johannes H.M., additional, and Shipley, Janet, additional

Published
2022
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33. Longitudinal Immune Response to 3 Doses of Messenger RNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Pediatric Patients Receiving Chemotherapy for Cancer

Author

Lehrnbecher, Thomas, primary, Sack, Ulrich, additional, Speckmann, Carsten, additional, Groll, Andreas H, additional, Boldt, Andreas, additional, Siebald, Benjamin, additional, Hettmer, Simone, additional, Demmerath, Eva-Maria, additional, Reemtsma, Judith, additional, Schenk, Barbara, additional, Ciesek, Sandra, additional, Klusmann, Jan-Henning, additional, Jassoy, Christian, additional, and Hoehl, Sebastian, additional

Published
2022
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34. Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report

Author

Drude, Natascha, primary, Martinez-Gamboa, Lorena, additional, Danziger, Meggie, additional, Collazo, Anja, additional, Kniffert, Silke, additional, Wiebach, Janine, additional, Nilsonne, Gustav, additional, Konietschke, Frank, additional, Piper, Sophie, additional, Pawel, Samuel, additional, Micheloud, Charlotte, additional, Held, Leonhard, additional, Frommlet, Florian, additional, Segelcke, Daniel, additional, Pogatzki-Zahn, Esther, additional, Voelkl, Bernhard, additional, Friede, Tim, additional, Brunner, Edgar, additional, Dempfle, Astrid, additional, Haller, Bernhard, additional, Jung, Marie Juliane, additional, Riecken, Lars Björn, additional, Kuhn, Georg, additional, Tenbusch, Matthias, additional, Higuita, Lina Maria Serna, additional, Remarque, Edmond J., additional, Grüninger, Servan, additional, Manske, Katrin, additional, Kobold, Sebastian, additional, Rivalan, Marion, additional, Wedekind, Lisa, additional, Wilcke, Juliane C., additional, Boulesteix, Anne-Laure, additional, Meinhardt, Marcus W., additional, Spanagel, Rainer, additional, Hettmer, Simone, additional, von Lüttichau, Irene, additional, Regina, Carla, additional, Dirnagl, Ulrich, additional, and Toelch, Ulf, additional

Published
2022
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35. ATRT-09. Outcome and therapeutic interventions in relapsed and refractory ATRT – The EU-RHAB perspective

Author

Steinbügl, Mona, primary, Nemes, Karolina, additional, Gruhle, Miriam, additional, Johann, Pascal, additional, Gil-da-Costa, Maria Joao, additional, Ebinger, Martin, additional, Sehested, Astrid, additional, Hauser, Peter, additional, Reinhard, Harald, additional, Hettmer, Simone, additional, Jakob, Marcus, additional, Rutkowski, Stefan, additional, Driever, Pablo Hernáiz, additional, Fleischhack, Gudrun, additional, Kerl, Kornelius, additional, Witt, Olaf, additional, Gerss, Joachim, additional, Siebert, Reiner, additional, Schüller, Ulrich, additional, Hasselblatt, Martin, additional, and Frühwald, Michael C, additional

Published
2022
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36. Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe

Author

Hettmer, Simone, Linardic, Corinne M, Kelsey, Anna, Rudzinski, Erin R, Vokuhl, Christian, Selfe, Joanna, Ruhen, Olivia, Shern, Jack F, Khan, Javed, Kovach, Alexander R, Lupo, Philip J, Gatz, Susanne A, Schäfer, Beat W, Volchenboum, Samuel, Minard-Colin, Véronique, Koscielniak, Ewa, Hawkins, Douglas S, Bisogno, Gianni, Sparber-Sauer, Monika, Venkatramani, Rajkumar, Merks, Johannes H M, Shipley, Janet, Hettmer, Simone, Linardic, Corinne M, Kelsey, Anna, Rudzinski, Erin R, Vokuhl, Christian, Selfe, Joanna, Ruhen, Olivia, Shern, Jack F, Khan, Javed, Kovach, Alexander R, Lupo, Philip J, Gatz, Susanne A, Schäfer, Beat W, Volchenboum, Samuel, Minard-Colin, Véronique, Koscielniak, Ewa, Hawkins, Douglas S, Bisogno, Gianni, Sparber-Sauer, Monika, Venkatramani, Rajkumar, Merks, Johannes H M, and Shipley, Janet

Abstract

Rhabdomyosarcomas (RMSs) are the most common soft tissue sarcomas in children/adolescents less than 18 years of age with an annual incidence of 1-2/million. Inter/intra-tumour heterogeneity raise challenges in clinical, pathological and biological research studies. Risk stratification in European and North American clinical trials previously relied on clinico-pathological features, but now, incorporates PAX3/7-FOXO1-fusion gene status in the place of alveolar histology. International working groups propose a coordinated approach through the INternational Soft Tissue SaRcoma ConsorTium to evaluate the specific genetic abnormalities and generate and integrate molecular and clinical data related to patients with RMS across different trial settings. We review relevant data and present a consensus view on what molecular features should be assessed. In particular, we recommend the assessment of the MYOD1-LR122R mutation for risk escalation, as it has been associated with poor outcomes in spindle/sclerosing RMS and rare RMS with classic embryonal histopathology. The prospective analyses of rare fusion genes beyond PAX3/7-FOXO1 will generate new data linked to outcomes and assessment of TP53 mutations and CDK4 amplification may confirm their prognostic value. Pathogenic/likely pathogenic germline variants in TP53 and other cancer predisposition genes should also be assessed. DNA/RNA profiling of tumours at diagnosis/relapse and serial analyses of plasma samples is recommended where possible to validate potential molecular biomarkers, identify new biomarkers and assess how liquid biopsy analyses can have the greatest benefit. Together with the development of new molecularly-derived therapeutic strategies that we review, a synchronised international approach is expected to enhance progress towards improved treatment assignment, management and outcomes for patients with RMS.

Published
2022

37. Longitudinal Immune Response to 3 Doses of Messenger RNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Pediatric Patients Receiving Chemotherapy for Cancer.

Author

Lehrnbecher, Thomas, Sack, Ulrich, Speckmann, Carsten, Groll, Andreas H, Boldt, Andreas, Siebald, Benjamin, Hettmer, Simone, Demmerath, Eva-Maria, Reemtsma, Judith, Schenk, Barbara, Ciesek, Sandra, Klusmann, Jan-Henning, Jassoy, Christian, and Hoehl, Sebastian

Subjects
RESEARCH, COVID-19, COVID-19 vaccines, CANCER chemotherapy, TUMORS in children, MESSENGER RNA, IMMUNITY, DESCRIPTIVE statistics, DATA analysis software
Abstract

Our study in 21 pediatric cancer patients demonstrates that 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccine (BioNTech/Pfizer) elicited both humoral and cellular immunity in most patients during chemotherapy. Immunity was stronger in children with solid tumors and during maintenance therapy compared to those with hematological malignancies or during intensive chemotherapy. Clinical Trials Registration. ȃGerman Registry for Clinical Trials (DRKS00025254). [ABSTRACT FROM AUTHOR]

Published
2023
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39. Additional file 1 of Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report

Author

Drude, Natascha Ingrid, Martinez-Gamboa, Lorena, Danziger, Meggie, Collazo, Anja, Kniffert, Silke, Wiebach, Janine, Nilsonne, Gustav, Konietschke, Frank, Piper, Sophie K., Pawel, Samuel, Micheloud, Charlotte, Held, Leonhard, Frommlet, Florian, Segelcke, Daniel, Pogatzki-Zahn, Esther M., Voelkl, Bernhard, Friede, Tim, Brunner, Edgar, Dempfle, Astrid, Haller, Bernhard, Jung, Marie Juliane, Riecken, Lars Björn, Kuhn, Hans-Georg, Tenbusch, Matthias, Higuita, Lina Maria Serna, Remarque, Edmond J., Grüninger-Egli, Servan Luciano, Manske, Katrin, Kobold, Sebastian, Rivalan, Marion, Wedekind, Lisa, Wilcke, Juliane C., Boulesteix, Anne-Laure, Meinhardt, Marcus W., Spanagel, Rainer, Hettmer, Simone, von Lüttichau, Irene, Regina, Carla, Dirnagl, Ulrich, and Toelch, Ulf

Abstract

Additional file 1: Figure S 1. Composition of workshop participants as per field of expertise. The organizing team mainly consists of meta-researchers with a clinical or preclinical background. Other refers to e.g., stakeholders from funding agencies that also attended the workshop. Methods S1. Multi-stakeholder workshop method-Workshop design. Glossary. Glossary of terms.

Published
2022
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40. Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells

Author

Bauer, Christoph, Quante, Meret, Breunis, Willemijn B, Regina, Carla, Schneider, Michaela, Andrieux, Geoffroy, Gorka, Oliver, Groß, Olaf, Boerries, Melanie, Kammerer, Bernd, Hettmer, Simone, University of Zurich, Kammerer, Bernd, and Hettmer, Simone

Subjects
sarcoma, 10036 Medical Clinic, reductive stress, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, metabolomics, Article, asparagine starvation
Abstract

Simple Summary Cancer cells require amino acids to grow and survive. Amino acid starvation inhibits cancer growth. This study investigates why the non-essential amino acid asparagine is important for cancer growth by examining metabolite composition in asparagine-deprived sarcoma cells compared to control cells with normal asparagine access. Our experiments show that asparagine deprivation results in an imbalance between certain antioxidants and free radicals in the cell. Chemicals which impair the regeneration of antioxidants in the cell augment the growth inhibition caused by asparagine starvation. Abstract Amino acids are integral components of cancer metabolism. The non-essential amino acid asparagine supports the growth and survival of various cancer cell types. Here, different mass spectrometry approaches were employed to identify lower aspartate levels, higher aspartate/glutamine ratios and lower tricarboxylic acid (TCA) cycle metabolite levels in asparagine-deprived sarcoma cells. Reduced nicotinamide adenine dinucleotide (NAD+)/nicotinamide adenine dinucleotide hydride (NADH) ratios were consistent with redirection of TCA cycle flux and relative electron acceptor deficiency. Elevated lactate/pyruvate ratios may be due to compensatory NAD+ regeneration through increased pyruvate to lactate conversion by lactate dehydrogenase. Supplementation with exogenous pyruvate, which serves as an electron acceptor, restored aspartate levels, NAD+/NADH ratios, lactate/pyruvate ratios and cell growth in asparagine-deprived cells. Chemicals disrupting NAD+ regeneration in the electron transport chain further enhanced the anti-proliferative and pro-apoptotic effects of asparagine depletion. We speculate that reductive stress may be a major contributor to the growth arrest observed in asparagine-starved cells.

Published
2021

45. Breast cancer characteristics and surgery among women with Li‐Fraumeni syndrome in Germany—A retrospective cohort study

Author

Rippinger, Nathalie, primary, Fischer, Christine, additional, Sinn, Hans‐Peter, additional, Dikow, Nicola, additional, Sutter, Christian, additional, Rhiem, Kerstin, additional, Grill, Sabine, additional, Cremer, Friedrich W., additional, Nguyen, Huu P., additional, Ditsch, Nina, additional, Kast, Karin, additional, Hettmer, Simone, additional, Kratz, Christian P., additional, and Schott, Sarah, additional

Published
2021
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46. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, additional, Pajtler, Kristian W., additional, Langenberg, Karin P.S., additional, Fiesel, Petra, additional, Jones, Barbara C., additional, Balasubramanian, Gnana Prakash, additional, Stark, Sebastian, additional, Johann, Pascal D., additional, Blattner-Johnson, Mirjam, additional, Schramm, Kathrin, additional, Dikow, Nicola, additional, Hirsch, Steffen, additional, Sutter, Christian, additional, Grund, Kerstin, additional, von Stackelberg, Arend, additional, Kulozik, Andreas E., additional, Lissat, Andrej, additional, Borkhardt, Arndt, additional, Meisel, Roland, additional, Reinhardt, Dirk, additional, Klusmann, Jan-Henning, additional, Fleischhack, Gudrun, additional, Tippelt, Stephan, additional, von Schweinitz, Dietrich, additional, Schmid, Irene, additional, Kramm, Christof M., additional, von Bueren, André O., additional, Calaminus, Gabriele, additional, Vorwerk, Peter, additional, Graf, Norbert, additional, Westermann, Frank, additional, Fischer, Matthias, additional, Eggert, Angelika, additional, Burkhardt, Birgit, additional, Wößmann, Wilhelm, additional, Nathrath, Michaela, additional, Hecker-Nolting, Stefanie, additional, Frühwald, Michael C., additional, Schneider, Dominik T., additional, Brecht, Ines B., additional, Ketteler, Petra, additional, Fulda, Simone, additional, Koscielniak, Ewa, additional, Meister, Michael T., additional, Scheer, Monika, additional, Hettmer, Simone, additional, Schwab, Matthias, additional, Tremmel, Roman, additional, Øra, Ingrid, additional, Hutter, Caroline, additional, Gerber, Nicolas U., additional, Lohi, Olli, additional, Kazanowska, Bernarda, additional, Kattamis, Antonis, additional, Filippidou, Maria, additional, Goemans, Bianca, additional, Zwaan, C. Michel, additional, Milde, Till, additional, Jäger, Natalie, additional, Wolf, Stephan, additional, Reuss, David, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Dirksen, Uta, additional, Freitag, Angelika, additional, Witt, Ruth, additional, Lichter, Peter, additional, Kopp-Schneider, Annette, additional, Jones, David T.W., additional, Molenaar, Jan J., additional, Capper, David, additional, Pfister, Stefan M., additional, and Witt, Olaf, additional

Published
2021
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47. Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors

Author

Steinbügl, Mona, primary, Nemes, Karolina, additional, Johann, Pascal, additional, Kröncke, Thomas, additional, Tüchert, Stefanie, additional, da Costa, Maria Joao Gil, additional, Ebinger, Martin, additional, Schüller, Ulrich, additional, Sehested, Astrid, additional, Hauser, Peter, additional, Reinhard, Harald, additional, Sumerauer, David, additional, Hettmer, Simone, additional, Jakob, Marcus, additional, Hasselblatt, Martin, additional, Siebert, Reiner, additional, Witt, Olaf, additional, Gerss, Joachim, additional, Kerl, Kornelius, additional, and Frühwald, Michael C., additional

Published
2021
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48. The landscape of genomic alterations across childhood cancers

Author

Grbner, Susanne N., Worst, Barbara C., Weischenfeldt, Joachim, Buchhalter, Ivo, Kleinheinz, Kortine, Rudneva, Vasilisa A., Johann, Pascal D., Balasubramanian, Gnana Prakash, Segura-Wang, Maia, Brabetz, Sebastian, Bender, Sebastian, Hutter, Barbara, Sturm, Dominik, Pfaff, Elke, Hbschmann, Daniel, Zipprich, Gideon, Heinold, Michael, Eils, Jrgen, Lawerenz, Christian, Erkek, Serap, Lambo, Sander, Waszak, Sebastian, Blattmann, Claudia, Borkhardt, Arndt, Kuhlen, Michaela, Eggert, Angelika, Fulda, Simone, Gessler, Manfred, Wegert, Jenny, Kappler, Roland, Baumhoer, Daniel, Burdach, Stefan, Kirschner-Schwabe, Renate, Kontny, Udo, Kulozik, Andreas E., Lohmann, Dietmar, Hettmer, Simone, Eckert, Cornelia, Bielack, Stefan, Nathrath, Michaela, Niemeyer, Charlotte, Richter, Gnther H., Schulte, Johannes, Siebert, Reiner, Westermann, Frank, Molenaar, Jan J., Vassal, Gilles, Witt, Hendrik, Lichter, Peter, Weber, Ursula, Eils, Roland, Korshunov, Andrey, Witt, Olaf, Pfister, Stefan, Reifenberger, Guido, Felsberg, Jrg, von Kalle, Christof, Schmidt, Manfred, Bartholom, Cynthia, Taylor, Michael, Jones, David, Jger, Natalie, Korbel, Jan, Sttz, Adrian, Rausch, Tobias, Radlwimmer, Bernhard, Yaspo, Marie-Laure, Lehrach, Hans, Warnatz, Hans-Jrg, Landgraf, Pablo, Brors, Benedikt, Zapatka, Marc, Wagner, Susanne, Haake, Andrea, Richter, Julia, Richter, Gesine, Lawerenz, Chris, Kerssemakers, Jules, Jaeger-Schmidt, Christina, Scholz, Ingrid, Bergmann, Anke K., Borst, Christoph, Burkhardt, Birgit, Claviez, Alexander, Dreyling, Martin, Eberth, Sonja, Einsele, Hermann, Frickhofen, Norbert, Haas, Siegfried, Hansmann, Martin-Leo, Karsch, Dennis, Kneba, Michael, Lisfeld, Jasmin, Mantovani-Lffler, Luisa, Rohde, Marius, Ott, German, Stadler, Christina, Staib, Peter, Stilgenbauer, Stephan, Trmper, Lorenz, Zenz, Thorsten, Kube, Dieter, Kppers, Ralf, Weniger, Marc, Hummel, Michael, Klapper, Wolfram, Kostezka, Ulrike, Lenze, Dido, Mller, Peter, Rosenwald, Andreas, Szczepanowski, Monika, Ammerpohl, Ole, Aukema, Sietse M., Binder, Vera, Hoell, Jessica I., Leich, Ellen, Lpez, Cristina, Nagel, Inga, Pischimariov, Jordan, Rosenstiel, Philip, Schilhabel, Markus, Schreiber, Stefan, Vater, Inga, Wagener, Rabea, Bernhart, Stephan H., Binder, Hans, Doose, Gero, Hoffmann, Steve, Hopp, Lydia, Kretzmer, Helene, Kreuz, Markus, Langenberger, David, Loeffler, Markus, Rosolowski, Maciej, Schlesner, Matthias, Stadler, Peter F., Sungalee, Stephanie, Kratz, Christian P., van Tilburg, Cornelis M., Kramm, Christof M., Fleischhack, Gudrun, Dirksen, Uta, Rutkowski, Stefan, Frhwald, Michael, von Hoff, Katja, Wolf, Stephan, Klingebiel, Thomas, Koscielniak, Ewa, Koster, Jan, Resnick, Adam C., Zhang, Jinghui, Liu, Yanling, Zhou, Xin, Waanders, Angela J., Zwijnenburg, Danny A., Raman, Pichai, Weber, Ursula D., Northcott, Paul A., Pajtler, Kristian W., Kool, Marcel, Piro, Rosario M., Korbel, Jan O., Jones, David T. W., Chavez, Lukas, and Pfister, Stefan M.

Subjects
Childhood cancer -- Genetic aspects, Cancer research, Gene mutation -- Health aspects, Genomics -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 78% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials., Author(s): Susanne N. Grbner [1, 2, 3]; Barbara C. Worst [1, 2, 3, 4]; Joachim Weischenfeldt [5, 6]; Ivo Buchhalter [7]; Kortine Kleinheinz [7]; Vasilisa A. Rudneva [5, 8]; Pascal [...]

Published
2018
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49. Author Correction: The landscape of genomic alterations across childhood cancers

Author

Gröbner, Susanne N., Worst, Barbara C., Weischenfeldt, Joachim, Buchhalter, Ivo, Kleinheinz, Kortine, Rudneva, Vasilisa A., Johann, Pascal D., Balasubramanian, Gnana Prakash, Segura-Wang, Maia, Brabetz, Sebastian, Bender, Sebastian, Hutter, Barbara, Sturm, Dominik, Pfaff, Elke, Hübschmann, Daniel, Zipprich, Gideon, Heinold, Michael, Eils, Jürgen, Lawerenz, Christian, Erkek, Serap, Lambo, Sander, Waszak, Sebastian, Blattmann, Claudia, Borkhardt, Arndt, Kuhlen, Michaela, Eggert, Angelika, Fulda, Simone, Gessler, Manfred, Wegert, Jenny, Kappler, Roland, Baumhoer, Daniel, Burdach, Stefan, Kirschner-Schwabe, Renate, Kontny, Udo, Kulozik, Andreas E., Lohmann, Dietmar, Hettmer, Simone, Eckert, Cornelia, Bielack, Stefan, Nathrath, Michaela, Niemeyer, Charlotte, Richter, Günther H., Schulte, Johannes, Siebert, Reiner, Westermann, Frank, Molenaar, Jan J., Vassal, Gilles, Witt, Hendrik, Burkhardt, Birgit, Kratz, Christian P., Witt, Olaf, van Tilburg, Cornelis M., Kramm, Christof M., Fleischhack, Gudrun, Dirksen, Uta, Rutkowski, Stefan, Frühwald, Michael, von Hoff, Katja, Wolf, Stephan, Klingebiel, Thomas, Koscielniak, Ewa, Landgraf, Pablo, Koster, Jan, Resnick, Adam C., Zhang, Jinghui, Liu, Yanling, Zhou, Xin, Waanders, Angela J., Zwijnenburg, Danny A., Raman, Pichai, Brors, Benedikt, Weber, Ursula D., Northcott, Paul A., Pajtler, Kristian W., Kool, Marcel, Piro, Rosario M., Korbel, Jan O., Schlesner, Matthias, Eils, Roland, Jones, David T. W., Lichter, Peter, Chavez, Lukas, Zapatka, Marc, Pfister, Stefan M., ICGC PedBrain-Seq Project, and ICGC MMML-Seq Project

Published
2018
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50. A Study of Regulatory Challenges of Pediatric Oncology Phase I/II Trial Submissions and Guidance on Protocol Development

Author

Beck, Lydia, primary, Witt, Ruth, additional, Nesper‐Brock, Martina, additional, Milde, Till, additional, Hettmer, Simone, additional, Frühwald, Michael C., additional, Rössig, Claudia, additional, Fischer, Matthias, additional, Reinhardt, Dirk, additional, Taylor, Lenka A., additional, Riedel, Claudia, additional, Witt, Olaf, additional, and Tilburg, Cornelis M., additional

Published
2021
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