19,875 results on '"Hetherington A"'
Search Results
2. Effectiveness of a Multifaceted Implementation Strategy to Increase Equitable Hospital at Home Utilization: An Interrupted Time Series Analysis
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Kowalkowski, Marc, Stephens, Casey, Hetherington, Timothy, Nguyen, Hieu, Bundy, Henry, Isreal, McKenzie, Hole, Colleen, Sunkara, Padageshwar, Nagaraj, Raghava, Sitammagari, Kranthi, Knight, Marvin, Marston, Susan, Palmer, Pooja, McWilliams, Andrew, and Murphy, Stephanie
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- 2024
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3. Data repairing and resolution enhancement using data-driven modal decomposition and deep learning
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Hetherington, A., Serfaty, D., Corrochano, A., Soria, J., and Clainche, S. Le
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Computer Science - Computational Engineering, Finance, and Science ,Physics - Fluid Dynamics - Abstract
This paper introduces a new series of methods which combine modal decomposition algorithms, such as singular value decomposition and high-order singular value decomposition, and deep learning architectures to repair, enhance, and increase the quality and precision of numerical and experimental data. A combination of two- and three-dimensional, numerical and experimental dasasets are used to demonstrate the reconstruction capacity of the presented methods, showing that these methods can be used to reconstruct any type of dataset, showing outstanding results when applied to highly complex data, which is noisy. The combination of benefits of these techniques results in a series of data-driven methods which are capable of repairing and/or enhancing the resolution of a dataset by identifying the underlying physics that define the data, which is incomplete or under-resolved, filtering any existing noise. These methods and the Python codes are included in the first release of ModelFLOWs-app.
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- 2024
4. The mediating role of kynurenine pathway metabolites on the relationship between inflammation and muscle mass in oldest-old men.
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Hetherington-Rauth, Megan, Johnson, Eileen, Migliavacca, Eugenia, Langsetmo, Lisa, Hepple, Russell T, Ryan, Terence E, Ferrucci, Luigi, Breuillé, Denis, Corthesy, John, Lane, Nancy E, Feige, Jérôme N, Napoli, Nicola, Tramontana, Flavia, Orwoll, Eric S, and Cawthon, Peggy M
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C-reactive protein ,D3-creatine ,biomarkers ,sarcopenia ,Clinical Sciences ,Gerontology ,Biomedical and clinical sciences ,Health sciences - Abstract
Tryptophan (TRP) metabolites along the kynurenine (KYN) pathway (KP) have been found to influence muscle. Pro-inflammatory cytokines are known to stimulate the degradation of TRP down the KP. Given that both inflammation and KP metabolites have been connected with loss of muscle, we assessed the potential mediating role of KP metabolites on inflammation and muscle mass in older men. 505 men (85.0±4.2yrs) from the Osteoporotic Fractures in Men cohort study with measured D3-creatine dilution (D3Cr) muscle mass, KP metabolites, and inflammation markers (C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP) and a subsample (n=305) with interleukin (IL-6, IL-1β, IL-17A) and tumor necrosis factor-α (TNF-α)) were included in the analysis. KP metabolites and inflammatory markers were measured using liquid chromatography-tandem mass spectrometry and immunoassays, respectively. 23-92% of the inverse relationship between inflammatory markers and D3Cr muscle mass was mediated by KP metabolites (indirect effect p0.05). KP metabolites, particularly higher ratios of KYN/TRP, 3-HK/XA, 3-HK/3-HAA, QA/3-HAA and a lower ratio of NAM/QA, mediated the relationship between inflammation and low muscle mass. Our preliminary cross-sectional data suggest that interventions to alter D3Cr muscle mass may focus on KP metabolites rather than inflammation per se.
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- 2024
5. Can the Administrative Loads of Physicians be Alleviated by AI-Facilitated Clinical Documentation?
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Bundy, Henry, Gerhart, Jay, Baek, Sally, Connor, Crystal Danielle, Isreal, McKenzie, Dharod, Ajay, Stephens, Casey, Liu, Tsai-Ling, Hetherington, Timothy, and Cleveland, Jeffery
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- 2024
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6. Impact of alfalfa perimeter strips on Lygus lineolaris and beneficial arthropods in June-bearing strawberry fields
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Hetherington, Matthew C., Fox, Matthew, Johnson, Megan, Lopina, Allison, Mechelke, Emma, Weissner, Morgan, and Guédot, Christelle
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- 2024
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7. Low-cost singular value decomposition with optimal sensor placement
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Hetherington, Ashton and Clainche, Soledad Le
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Computer Science - Computational Engineering, Finance, and Science - Abstract
This paper presents a new method capable of reconstructing datasets with great precision and very low computational cost using a novel variant of the singular value decomposition (SVD) algorithm that has been named low-cost SVD (lcSVD). This algorithm allows to reconstruct a dataset from a minimum amount of points, that can be selected randomly, equidistantly or can be calculated using the optimal sensor placement functionality that is also presented in this paper, which finds minimizing the reconstruction error to validate the calculated sensor positions. This method also allows to find the optimal number of sensors, aiding users in optimizing experimental data recollection. The method is tested in a series of datasets, which vary between experimental and numerical simulations, two- and three-dimensional data and laminar and turbulent flow, which have been used to demonstrate the capacity of this method based on its high reconstruction accuracy, robustness, and computational resource optimization. Maximum speed-up factors of 630 and memory reduction of 37% are found when compared to the application of standard SVD to the dataset. This method will be incorporated into ModelFLOWs-app's next version release.
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- 2023
8. Improving delirium assessments in acute senior health: A quality improvement project for care of the older person
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Charles Taylor, Georgia Peakman, Lauren Mackinnon, Navid Mohamadzade, Wayne Han, Lucy Mackie, Jasmine Gandhi, Oliver Mitchell, Caitlin Bateman-Champain, Joseph Hetherington, Fahed Belarbi, and Gaggandeep Alg
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Delirium ,Dementia ,Geriatrics ,Frailty ,Quality Improvement ,RC952-954.6 - Abstract
Abstract Background Delirium is a common and reversible neurobehavioral condition with significant morbidity and mortality ramifications for older patients. Consequentially, clear guidelines exist pertaining to its swift identification and management. However, studies suggest that adherence to these guidelines are poor. This audit aimed to evaluate compliance to the National Institute for Health and Care Excellence’s (NICE) delirium guidelines in an Acute Senior Health Unit (ASHU) and to present a single centre experience of a low-cost ward-based intervention for improving delirium guideline adherence. Methods A retrospective observational audit was conducted on patients admitted to ASHU between 01/07/2023 and 30/07/2023. Data on delirium assessments, diagnoses and causes of delirium were obtained through retrospective database searches. Posters and education based multidisciplinary team (MDT) interventions were designed and initiated following grounded thematic literature analysis and ward discussion. A methodically equivalent audit was then conducted between 01/09/2023 and 30/09/23. Data was anonymised and blinded and analysis was performed on SPSS V12.0. Results A total of 128 patients were included in the study. Initial audit revealed suboptimal compliance with NICE recommendations. Chi-square test of independence found that patients were statistically more likely to receive a full delirium assessment (1.9% vs. 56.6%, p = 0.001) and formal diagnosis (5.8% vs. 27.6%, p = 0.002) after the ward-based intervention. Conclusion This study provides limited evidence in favour of low-cost MDT based interventions for improving adherence to NICE delirium guidelines and provides a 5-step framework for future studies. This study also explores the potential patient implications of these interventions. A repeat audit should be conducted to ensure lasting and sustainable change is achieved. Trial registration/clinical trial number AUDI003614.
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- 2024
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9. Creative Pedagogies in Digital STEAM Practices: Natural, Technological and Cultural Entanglements for Powerful Learning and Activism
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Kerry Chappell and Lindsay Hetherington
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This paper delves deeply into the creative pedagogies which support cutting edge digital STEAM practice across primary and secondary school settings. It contextualises the research within current STEAM agendas including transdisciplinarity, and STEAM and technology and goes on to offer insight from the novel context of ocean learning to develop and extend a theorisation of creative pedagogies as entwining both creative teaching and teaching for creativity as embodied, democratic, dialogic and material processes. Intra-action between theory, praxis, nature, culture, the digital and humans enables an emergent perspective about changing the dynamics of power to develop ocean or environmental learning and related activism. Derived from research into an ocean education project, which aimed to develop students' ocean literacy through the combined educative principles of creative pedagogies and digital technologies (Augmented and Virtual Realities), the research draws on data from six projects across primary and secondary school settings in Denmark, Spain and England. It used a "diffractive" analytic technique, inspired by new materialist theory, to explore the messy mixtures of natural, cultural and technological environments that were being learned through. This involved the development of four material-dialogic assemblages each including diffractive switches. Each is presented first through a "piece" which demonstrates each assemblage's connection to the core question, followed by "ripples," which briefly articulate the new learning and questions arising from that assemblage. The four assemblages cover the irresistibility of making kin, the relationships between lively bodies and virtual environments, the importance of spacetimematter in environmental edu-activism and trajectories between transience, stability and dialogic space. The paper leaves the reader/engager with a selection of prompts to highlight the research's contribution to current STEAM agendas related to changing power dynamics, and to provoke reader/engagers' own practices. These can include new pedagogies and activisms, as well as theoretical developments to the combined educative principles of creative pedagogies and digital technologies within STEAM education.
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- 2024
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10. Teaching the limitations of AI as a writing tool
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Hetherington, Scott
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- 2024
11. Improving delirium assessments in acute senior health: A quality improvement project for care of the older person
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Taylor, Charles, Peakman, Georgia, Mackinnon, Lauren, Mohamadzade, Navid, Han, Wayne, Mackie, Lucy, Gandhi, Jasmine, Mitchell, Oliver, Bateman-Champain, Caitlin, Hetherington, Joseph, Belarbi, Fahed, and Alg, Gaggandeep
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- 2024
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12. The Ex-Timing trial: evaluating morning, afternoon, and evening exercise on the circadian clock in individuals with type 2 diabetes and overweight/obesity—a randomized crossover study protocol
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Magalhães, João P., Oliveira, Estela C., Hetherington-Rauth, Megan, Jesus, Filipe, Rodrigues, Maria Clarissa, Raposo, João F., Ribeiro, Rogério T., Caetano, Cristina, and Sardinha, Luís B.
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- 2024
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13. Simplifying informed consent as a universal precaution
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Feinberg, Iris Z., Gajra, Ajeet, Hetherington, Lori, and McCarthy, Kathryn S.
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- 2024
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14. A geopolitical-economy of distant water fisheries access arrangements
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Campling, Liam, Havice, Elizabeth, Virdin, John, Carmine, Gabrielle, Andriamahefazafy, Mialy, Barbesgaard, Mads, Chakravarty, Siddharth, Gorez, Béatrice, Hetherington, Dan, Kim, Hyunjung, Mfodwo, Kwame, and Standing, Andre
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- 2024
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15. Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
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Michael, Benedict D., Dunai, Cordelia, Needham, Edward J., Tharmaratnam, Kukatharmini, Williams, Robyn, Huang, Yun, Boardman, Sarah A., Clark, Jordan J., Sharma, Parul, Subramaniam, Krishanthi, Wood, Greta K., Collie, Ceryce, Digby, Richard, Ren, Alexander, Norton, Emma, Leibowitz, Maya, Ebrahimi, Soraya, Fower, Andrew, Fox, Hannah, Tato, Esteban, Ellul, Mark A., Sunderland, Geraint, Held, Marie, Hetherington, Claire, Egbe, Franklyn N., Palmos, Alish, Stirrups, Kathy, Grundmann, Alexander, Chiollaz, Anne-Cecile, Sanchez, Jean-Charles, Stewart, James P., Griffiths, Michael, Solomon, Tom, Breen, Gerome, Coles, Alasdair J., Kingston, Nathalie, Bradley, John R., Chinnery, Patrick F., Cavanagh, Jonathan, Irani, Sarosh R., Vincent, Angela, Baillie, J. Kenneth, Openshaw, Peter J., Semple, Malcolm G., Taams, Leonie S., and Menon, David K.
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- 2024
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16. Contextualizing remote fall risk: Video data capture and implementing ethical AI
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Moore, Jason, McMeekin, Peter, Parkes, Thomas, Walker, Richard, Morris, Rosie, Stuart, Samuel, Hetherington, Victoria, and Godfrey, Alan
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- 2024
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17. Association of social vulnerability index and masking adherence among children enrolled in COVID-19 community research partnership study
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Dantuluri, Keerti L., Buahin, Asare, Uschner, Diane, DeWitt, Michael E., Rossman, Whitney, Dunn, Connell O., Hetherington, Timothy C., Priem, Jennifer, Castri, Paola, Lagarde, William H., Gibbs, Michael, and Ahmed, Amina
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- 2024
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18. Electrophysiological and behavioral responses of Lygus hesperus Knight (Hemiptera: Miridae) to host plant volatiles
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Hetherington, Matthew C., Brunet, Johanne, Nieto, Diego, Ramirez, Ricardo A., Wenninger, Erik J., and Guédot, Christelle
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- 2024
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19. Creative pedagogies in digital STEAM practices: natural, technological and cultural entanglements for powerful learning and activism
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Chappell, Kerry and Hetherington, Lindsay
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- 2024
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20. ModelFLOWs-app: data-driven post-processing and reduced order modelling tools
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Hetherington, A., Corrochano, A., Abadía-Heredia, R., Lazpita, E., Muñoz, E., Díaz, P., Moira, E., López-Martín, M., and Clainche, S. Le
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Computer Science - Computational Engineering, Finance, and Science ,Electrical Engineering and Systems Science - Systems and Control - Abstract
This article presents an innovative open-source software named ModelFLOWs-app, written in Python, which has been created and tested to generate precise and robust hybrid reduced order models (ROMs) fully data-driven. By integrating modal decomposition and deep learning methods in diverse ways, the software uncovers the fundamental patterns in dynamic systems. This acquired knowledge is then employed to enrich the comprehension of the underlying physics, reconstruct databases from limited measurements, and forecast the progression of system dynamics. These hybrid models combine experimental and numerical database, and serve as accurate alternatives to numerical simulations, effectively diminishing computational expenses, and also as tools for optimization and control. The ModelFLOWs-app software has demonstrated in a wide range of applications its great capability to develop reliable data-driven hybrid ROMs, highlighting its potential in understanding complex non-linear dynamical systems and offering valuable insights into various applications. This article presents the mathematical background, review some examples of applications and introduces a short tutorial of ModelFLOWs-app.
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- 2023
21. The Ex-Timing trial: evaluating morning, afternoon, and evening exercise on the circadian clock in individuals with type 2 diabetes and overweight/obesity—a randomized crossover study protocol
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João P. Magalhães, Estela C. Oliveira, Megan Hetherington-Rauth, Filipe Jesus, Maria Clarissa Rodrigues, João F. Raposo, Rogério T. Ribeiro, Cristina Caetano, and Luís B. Sardinha
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Glycemic control ,Inter-individual variability ,Aging ,Obesity ,Crossover randomized controlled trial ,Medicine (General) ,R5-920 - Abstract
Abstract Background Exercise is known to provide multiple metabolic benefits such as improved insulin sensitivity and glucose control in individuals with type 2 diabetes mellitus (T2DM) and those at risk. Beyond the traditional exercise dose, exercise timing is perceived as a contemporary hot topic, especially in the field of T2DM; however, the number of intervention studies assessing exercise timing and glucose metabolism is scarce. Our aim is to test the effect of exercise timing (i.e., morning, afternoon, or evening) on the inter-individual response variability in glycemic control and related metabolic health parameters in individuals with T2DM and those at risk during a 12-week intervention. Methods A randomized crossover exercise intervention will be conducted involving two groups: group 1, individuals with T2DM; group 2, age-matched older adults with overweight/obesity. The intervention will consist of three 2-week blocks of supervised post-prandial exercise using high-intensity interval training (HIIT). Between each training block, a 2-week washout period, where participants avoid structured exercise, will take place. Assessments will be conducted in both groups before and after each exercise block. The primary outcomes include the 24-h area under the curve continuous glucose monitoring-based glucose. The secondary outcomes include body composition, resting energy expenditure, insulin response to a meal tolerance test, maximal aerobic capacity, peak power output, physical activity, sleep quality, and insulin and glucose levels. All primary and secondary outcomes will be measured at each assessment point. Discussion Outcomes from this trial will provide us additional insight into the role of exercise timing on the inter-individual response variability in glycemic control and other related metabolic parameters in two distinct populations, thus contributing to the development of more effective exercise prescription guidelines for individuals with T2DM and those at risk. Trial registration ClinicalTrials.gov NCT06136013. Registered on November 18, 2023.
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- 2024
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22. Scanning WAXS microscopy of regenerated cellulose fibers at mesoscopic resolution
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Sara Johansson, Francesco Scattarella, Sebastian Kalbfleisch, Ulf Johansson, Christopher Ward, Crispin Hetherington, Herbert Sixta, Stephen Hall, Cinzia Giannini, and Ulf Olsson
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nanofocus x-ray probe ,scanning waxs ,regenerated cellulose fibers ,materials science ,crystallization ,crystal growth ,properties of solids ,Crystallography ,QD901-999 - Abstract
In this work, regenerated cellulose textile fibers, Ioncell-F, dry-wet spun with different draw ratios, have been investigated by scanning wide-angle X-ray scattering (WAXS) using a mesoscopic X-ray beam. The fibers were found to be homogeneous on the 500 nm length scale. Analysis of the azimuthal angular dependence of a crystalline Bragg spot intensity revealed a radial dependence of the degree of orientation of crystallites that was found to increase with the distance from the center of the fiber. We attribute this to radial velocity gradients during the extrusion of the spin dope and the early stage of drawing. On the other hand, the fiber crystallinity was found to be essentially homogeneous over the fiber cross section.
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- 2024
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23. Simplifying informed consent as a universal precaution
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Iris Z. Feinberg, Ajeet Gajra, Lori Hetherington, and Kathryn S. McCarthy
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Medicine ,Science - Abstract
Abstract One barrier to participating in clinical research is that patients with low literacy skills (1 in 5 US adults) may struggle to understand the informed consent document (ICD). Writing consents using health literacy and plain language guidelines including simplified syntax and semantics can increase understandability and facilitate inclusivity of research populations with literacy challenges. Our study aim was to evaluate a simplified ICD for understandability while considering factors known to relate to comprehension (reading skills and working memory). We performed an on-line survey of 192 adults ages 18–77 in Georgia. Participants performed significantly better on the simplified ICD test. We built an additional model with all version x measure interactions (i.e., age, sex, race, urbanicity, GMVT, WM). This model did not significantly improve model fit, F
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- 2024
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24. Dark Poetry and the Anti-Elegiac: Approaching the Unspeakable
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Miller, Alyson, Atherton, Cassandra, and Hetherington, Paul
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- 2024
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25. Counter-stereotypical messaging and partisan cues: Moving the needle on vaccines in a polarized United States
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Larsen, Bradley J, Ryan, Timothy J, Greene, Steven, Hetherington, Marc J, Maxwell, Rahsaan, and Tadelis, Steven
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Immunization ,Clinical Research ,Clinical Trials and Supportive Activities ,Vaccine Related ,Prevention ,Good Health and Well Being ,Humans ,United States ,COVID-19 ,COVID-19 Vaccines ,Cues ,Vaccines ,Politics - Abstract
This paper reports results from a large-scale randomized controlled trial assessing whether counter-stereotypical messaging and partisan cues can induce people to get COVID-19 vaccines. The study used a 27-s video compilation of Donald Trump's comments about the vaccine from Fox News interviews and presented the video to millions of U.S. YouTube users through a $100,000 advertising campaign in October 2021. Results indicate that the number of vaccines increased in the average treated county by 103 (with a one-tailed P value of 0.097). Based on this average treatment effect and totaling across our 1014 treated counties, the total estimated effect was 104,036 vaccines.
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- 2023
26. Report on the Third Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE3)
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Katz, Daniel S, Choi, Sou-Cheng T, Niemeyer, Kyle E, Hetherington, James, Löffler, Frank, Gunter, Dan, Idaszak, Ray, Brandt, Steven R, Miller, Mark A, Gesing, Sandra, Jones, Nick D, Weber, Nic, Marru, Suresh, Allen, Gabrielle, Penzenstadler, Birgit, Venters, Colin C, Davis, Ethan, Hwang, Lorraine, Todorov, Ilian, Patra, Abani, and de Val-Borro, Miguel
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Bioengineering ,Sustainable Cities and Communities - Published
- 2023
27. Panel discussion: Publishing
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Hetherington, Alistair, speaker, Austin, Amy, speaker, Knowlton, Anne, speaker, and Öpik, Maarja, speaker
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- 2024
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28. Models and modelling in science teaching
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Hetherington, Lindsay, primary and Mead, Sam, additional
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- 2024
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29. Learning to Teach Science in the Secondary School
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Hetherington, Lindsay, primary, Graham, Luke, additional, and Moore, Darren, additional
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- 2024
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30. Introduction
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Hetherington, Lindsay, primary, Moore, Darren, additional, and Graham, Luke, additional
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- 2024
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31. Future directions for deep ocean climate science and evidence-based decision making
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Helen R. Pillar, Elizabeth Hetherington, Lisa A. Levin, Laura Cimoli, Jonathan M. Lauderdale, Jesse M. A. van der Grient, Kristen Johannes, Patrick Heimbach, Leslie Smith, Charles I. Addey, Pavanee Annasawmy, Sandra Antonio, Narissa Bax, Henri F. Drake, Elva Escobar, Laura G. Elsler, Mara A. Freilich, Natalya D. Gallo, Fanny Girard, Matthew J. Harke, Daniel O. B. Jones, Siddhi Joshi, Xinfeng Liang, Paige J. Maroni, Otmane Sarti, Paris V. Stefanoudis, Olivier Sulpis, and David Trossman
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deep sea ,climate science ,evidence-based decision making ,IPCC ,uncertainty ,vulnerability and risk ,Environmental sciences ,GE1-350 - Abstract
IntroductionA defining aspect of the Intergovernmental Panel on Climate Change (IPCC) assessment reports (AR) is a formal uncertainty language framework that emphasizes higher certainty issues across the reports, especially in the executive summaries and short summaries for policymakers. As a result, potentially significant risks involving understudied components of the climate system are shielded from view.MethodsHere we seek to address this in the latest, sixth assessment report (AR6) for one such component—the deep ocean—by summarizing major uncertainties (based on discussions of low confidence issues or gaps) regarding its role in our changing climate system. The goal is to identify key research priorities to improve IPCC confidence levels in deep ocean systems and facilitate the dissemination of IPCC results regarding potentially high impact deep ocean processes to decision-makers. This will accelerate improvement of global climate projections and aid in informing efforts to mitigate climate change impacts. An analysis of 3,000 pages across the six selected AR6 reports revealed 219 major science gaps related to the deep ocean. These were categorized by climate stressor and nature of impacts.ResultsHalf of these are biological science gaps, primarily surrounding our understanding of changes in ocean ecosystems, fisheries, and primary productivity. The remaining science gaps are related to uncertainties in the physical (32%) and biogeochemical (15%) ocean states and processes. Model deficiencies are the leading cited cause of low certainty in the physical ocean and ice states, whereas causes of biological uncertainties are most often attributed to limited studies and observations or conflicting results.DiscussionKey areas for coordinated effort within the deep ocean observing and modeling community have emerged, which will improve confidence in the deep ocean state and its ongoing changes for the next assessment report. This list of key “known unknowns” includes meridional overturning circulation, ocean deoxygenation and acidification, primary production, food supply and the ocean carbon cycle, climate change impacts on ocean ecosystems and fisheries, and ocean-based climate interventions. From these findings, we offer recommendations for AR7 to avoid omitting low confidence-high risk changes in the climate system.
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- 2024
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32. Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain
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Cordelia Dunai, Claire Hetherington, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Kukatharmini Tharmaratnam, Edward J. Needham, Robyn Williams, Yun Huang, Greta K. Wood, Ceryce Collie, Andrew Fower, Hannah Fox, Mark A. Ellul, Marie Held, Franklyn N. Egbe, Michael Griffiths, Tom Solomon, Gerome Breen, Anja Kipar, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, James P. Stewart, Leonie S. Taams, David K. Menon, and Benedict D. Michael
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virology ,immunology ,SARS-CoV-2 ,neurology ,microglia ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in the brain parenchyma. To model this situation, we developed a novel low-inoculum K18-hACE2 mouse model of SARS-CoV-2 infection during which active viral replication was consistently seen in mouse lungs but not in the brain. We found that several mediators previously associated with encephalopathy in clinical samples were upregulated in the lung, including CCL2, and IL-6. In addition, several inflammatory mediations, including CCL4, IFNγ, IL-17A, were upregulated in the brain, associated with microglial reactivity. Parallel in vitro experiments demonstrated that the filtered supernatant from SARS-CoV-2 virion exposed brain endothelial cells induced activation of uninfected microglia. This model successfully recreates SARS-CoV-2 virus-associated para-infectious brain inflammation which can be used to study the pathophysiology of the neurological complications and the identification of potential immune targets for treatment.
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- 2024
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33. The patent and the freezer: putting agrarian facts in their place
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Kregg Hetherington
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Green Revolution ,facticity ,conservation ,infrastructure ,agrarian science ,Revolução Verde ,Technology (General) ,T1-995 ,Social sciences (General) ,H1-99 - Abstract
This paper is a reflection on the growth and decline of Paraguayan scientific institutions associated with the Green Revolution. Paraguay had almost no scientific infrastructure in 1943, when American investors and politicians began a massive program to generate national expertise to fuel an export boom. This would be mirrored in the 1990s by disinvestment, personified in this paper by the demise of a vital freezer that was storing corn samples at one of the country’s primary research centers. The paper follows this story by focusing on four of the key crops of Paraguayan agrarian research: cotton, maize, wheat, and soybeans. Each of these crops in their time articulated ambivalent interests between those of the Paraguayan nation, and the global ambitions of foreign Green Revolutionaries. By showing the way that the latter interests slowly took over from the former (culminating in the patent regimes around genetically modified soybeans), the paper also traces the rising importance of “facticity” in local agrarian science.
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- 2024
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34. A geopolitical-economy of distant water fisheries access arrangements
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Liam Campling, Elizabeth Havice, John Virdin, Gabrielle Carmine, Mialy Andriamahefazafy, Mads Barbesgaard, Siddharth Chakravarty, Béatrice Gorez, Dan Hetherington, Hyunjung Kim, Kwame Mfodwo, and Andre Standing
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Oceanography ,GC1-1581 ,Environmental sciences ,GE1-350 - Abstract
Abstract In recent decades, fishing fleets and effort have grown in aggregate throughout the waters of lower-income coastal countries, much of which is carried out by vessels registered in higher-income countries. Fisheries access arrangements (FAAs) underpin this key trend in ocean fisheries and have their origins in UNCLOS’s promise to establish resource ownership as a mechanism to increase benefits to newly independent coastal and island states. Coastal states use FAAs to permit a foreign state, firm, or industry association to fish within its waters. This paper provides a conceptual approach for understanding FAAs across the global ocean and for exploring their potential to deliver on the promise of UNCLOS. Illustrated with the findings from multiple case studies, we advance understanding of FAAs by developing a geopolitical-economy of access that attends to the combination of contingent and context-specific economic, ecologic, and geopolitical forces that shape the terms, conditions and practices of the FAAs shaping this persistent phenomenon of higher-income industrial fleets fishing throughout lower-income countries’ waters.
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- 2024
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35. Contextualizing remote fall risk: Video data capture and implementing ethical AI
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Jason Moore, Peter McMeekin, Thomas Parkes, Richard Walker, Rosie Morris, Samuel Stuart, Victoria Hetherington, and Alan Godfrey
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Wearable inertial measurement units (IMUs) are being used to quantify gait characteristics that are associated with increased fall risk, but the current limitation is the lack of contextual information that would clarify IMU data. Use of wearable video-based cameras would provide a comprehensive understanding of an individual’s habitual fall risk, adding context to clarify abnormal IMU data. Generally, there is taboo when suggesting the use of wearable cameras to capture real-world video, clinical and patient apprehension due to ethical and privacy concerns. This perspective proposes that routine use of wearable cameras could be realized within digital medicine through AI-based computer vision models to obfuscate/blur/shade sensitive information while preserving helpful contextual information for a comprehensive patient assessment. Specifically, no person sees the raw video data to understand context, rather AI interprets the raw video data first to blur sensitive objects and uphold privacy. That may be more routinely achieved than one imagines as contemporary resources exist. Here, to showcase/display the potential an exemplar model is suggested via off-the-shelf methods to detect and blur sensitive objects (e.g., people) with an accuracy of 88%. Here, the benefit of the proposed approach includes a more comprehensive understanding of an individual’s free-living fall risk (from free-living IMU-based gait) without compromising privacy. More generally, the video and AI approach could be used beyond fall risk to better inform habitual experiences and challenges across a range of clinical cohorts. Medicine is becoming more receptive to wearables as a helpful toolbox, camera-based devices should be plausible instruments.
- Published
- 2024
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36. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, 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A, Watson, E, Watson, F, Watson, J, Watson, K, Watson, L, Watson, P, Watson, R, Watters, M, Watterson, D, Watts, D, Watts, J, Watts, M, Waugh, V, Wayman, M, Wazir, A, Weatherhead, M, Weatherly, N, Webb, C, Webb, H, Webb, K, Webb, S, Websdale, C, Webster, D, Webster, I, Webster, J, Webster, T, Wedlin, J, Wee, L, Weerakoon, R, Weerasinghe, T, Weeratunga, J, Weetman, M, Wei, S, Weichert, I, Welch, E, Welch, H, Welch, L, Welch, S, Welham, B, Weller, S, Wellings, L, Wells, B, Wellstead, S, Welsh, B, Welters, I, Welton, R, Wenn, V, Wentworth, L, Wesonga, J, Wesseldine, K, West, J, West, M, West, R, West, S, Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, H, Williamson, R, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Wilson, A, Wilson, B, Wilson, D, Willson, F, Wilson, I, Willson, J, Wilson, K-A, Wilson, L, Wilson, M, Wilson, T, Win, K, Win, M, Win, T, Win, W, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, 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P, Wubetu, J, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, B, Xia, Z, Y Ellis, T, Yacoba, E, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, W, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, M, Yates, T, Ye, J, Yearwood Martin, C, Yein, K, Yeoh, A, Yeung, C, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yu, C, Yuan, J, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-M, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, E, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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37. Extreme Philosophy
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Hetherington, Stephen, primary
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- 2024
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38. Knowing as Merely Being Correct
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Hetherington, Stephen, primary
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- 2024
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39. The feasibility and acceptability of collecting psychosocial outcome measures embedded within a precision medicine trial for childhood cancer
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Eden G. Robertson, Kate Hetherington, Rebecca Daly, Mark W. Donoghoe, Nicholas Handelsman, David S. Ziegler, and Claire E. Wakefield
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acceptability ,clinical trial ,feasibility ,oncology ,outcome measures ,paediatric ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Patient‐reported outcomes measures (PROMs) are increasingly being collected within cancer clinical trials, yet limited literature on the feasibility and acceptability of doing so. Methods We collected parent‐proxy and adolescent (≥12 years old) PROMs through a longitudinal, psychosocial sub‐study (‘PRISM‐Impact’) embedded in a precision medicine trial for children with poor prognosis cancer (‘PRISM’). We report on feasibility (response, participation, and attrition rates; follow‐up and responding to elevated distress) and acceptability (parents’ perceived benefit/burden of participation; and impact on decision to participate in PRISM) of PRISM‐Impact. Results Over the reporting period, 462 families were eligible for PRISM‐Impact. Family and adolescent response rates were 53% and 45%, respectively. Parents whose child had relapsed were more likely to participate in PRISM‐Impact than parents whose child had not (p
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40. 3. The Nansen Passport as Site of International and Exilic Memory
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Hetherington, Philippa, primary
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- 2023
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41. Creative rewriting and recontextualisation: fluid and shape-shifting literary works
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Hetherington, Paul, primary
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- 2023
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42. Using Donald Trump's COVID-19 Vaccine Endorsement to Give Public Health a Shot in the Arm: A Large-Scale Ad Experiment
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Larsen, Bradley J., Ryan, Timothy J., Greene, Steven, Hetherington, Marc J., Maxwell, Rahsaan, and Tadelis, Steven
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Economics - General Economics - Abstract
We report a large-scale randomized controlled trial designed to assess whether the partisan cue of a pro-vaccine message from Donald Trump would induce Americans to get COVID-19 vaccines. Our study involved presenting a 27-second advertisement to millions of U.S. YouTube users in October 2021. Results indicate that the campaign increased the number of vaccines in the average treated county by 103. Spread across 1,014 treated counties, the total effect of the campaign was an estimated increase of 104,036 vaccines. The campaign was cost-effective: with an overall budget of about \$100,000, the cost to obtain an additional vaccine was about \$1 or less.
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43. The role of piracy in the British empire
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Hetherington, Scott
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- 2021
44. Better understanding fall risk: AI-based computer vision for contextual gait assessment
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Moore, Jason, McMeekin, Peter, Stuart, Samuel, Morris, Rosie, Celik, Yunus, Walker, Richard, Hetherington, Victoria, and Godfrey, Alan
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- 2024
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45. Barriers to circular economy adoption are diverse and some are business-model specific: Evidence from the Australian cheese manufacturing sector
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Hetherington, Jack B., Loch, Adam J., Juliano, Pablo, and Umberger, Wendy J.
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46. Eating vegetables at school lunchtimes: Pilot and feasibility studies testing strategies to improve intake
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Chawner, L.R., Birtill, P., Cockroft, J.E., and Hetherington, M.M.
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47. Soft X-ray performance of an optimised charge-coupled device for astronomy
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Buggey, T.W., Randall, G., Parsons, S., Jones, L.S., DeCaire, A.L., Arnold, T., Hetherington, O., Holland, A.D., and Hall, D.J.
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- 2024
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48. Parents’ and patients’ perspectives, experiences, and preferences for germline genetic or genomic testing of children with cancer: A systematic review
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Hunter, Jacqueline D., Hetherington, Kate, Courtney, Eliza, Christensen, Yasmin, Fuentes-Bolanos, Noemi, Bhatia, Kanika, and Peate, Michelle
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- 2024
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49. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, Adcock, K, Addai-Boampong, L, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, FW, Adesemoye, OA, Adewunmi, EO, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikari, B, Adhikari, SA, Adhikary, R, Aditya, A, Adjepong, P, Adkins, G, Adnan, A, Adriaanse, M, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Afrim, P, Afriyie, FA, Aftab, ZA, Afum-Adjei Awuah, A, Agarwal, M, Agasiya, PN, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Agyekum, JA, Agyen, K, Ahadome, EK, Ahamed Sadiq, S, Ahammed Nazeer, MH, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, BAR, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmed, M, Ahmed, MC, Ahmed, MS, Ahmed, N, Ahmed, O, Ahmed, RA, Ahmed, R, Ahmed, S, Ahmed, SG, Ahmed, SH, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aidoo, C, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, ASAR, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albertus, A, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Ale, RM, Alegria, A, Alexander, A, Alexander, C, Alexander, J, Alexander, PDG, Al-fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, FR, Ali, J, Ali, M, Ali, MS, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Alisjahbana, B, Aliyuda, F, Alizadeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsop, HK, Allsop, L, Allsup, D, Almahroos, AFT, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Amelia Ganefianty, A, Ames, K, Amezaga, MR, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amoah-Dankwa, J, Amoako-Adusei, A, Amosun, V, Amsal, M, Amsha, K, Amuasi, J, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, SD, Andari, NKN, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, WW, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Ansah, M, Anstey, PJ, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonina, Z, Anu, V, Anwar, M, Anwar, S, Apetri, E, Apostolopoulos, A, Appleby, S, Appleyard, D, Aquino, MF, Araba, B, Aransiola, S, Araujo, M, Archer, A, Archer, D, Archer, S, Arcoria, D, Ardley, C, Arhin-Sam, G, Arias, A-M, Aribike, O, Arimoto, R, Arisanti, NLPE, Arkley, C, Armah, C, Armata, I, Armistead, J, Armitage, A, Armstrong, C, Armstrong, M, Armstrong, S, Armstrong, W, Armtrong, P, Arndt, H, Arnison-Newgass, C, Arnold, D, Arnold, R, Arnott, A, Arora, D, Arora, K, Arora, P, Arora, R, Arter, A, Arthur, A, Artini, NM, Arumaithurai, A, Arya, A, Arya, R, Aryal, D, Asandei, D, Asare, GA, Asghar, A, Asghar, M, Ashab, A, Ashbrook-Raby, C, Ashby, H, Ashcroft, J, Ashcroft, S, Asher, G, Ashfak, Z, Ashfaq, A, Asiamah, HA, Ashish, A, Ashley, D, Ashman-Flavell, S, Ashok, S, Ashour, A-E-A, Ashraf, MZ, Ashraf, S, Ashraq, MB, Ashton, D, Ashton, S, Ashworth, A, Ashworth, FJ, Ashworth, R, Aslam, A, Aslam, I, Aslam, S, Aslett, L, Asogan, H, Asrar, A, Assaf, O, Astin-Chamberlain, R, Atabudzi, YE, Athavale, P, Athorne, D, Atkins, B, Atkins, C, Atkins, S, Atkinson, J, 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- Published
- 2023
- Full Text
- View/download PDF
50. Association of social vulnerability index and masking adherence among children enrolled in COVID-19 community research partnership study
- Author
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Keerti L. Dantuluri, Asare Buahin, Diane Uschner, Michael E. DeWitt, Whitney Rossman, Connell O. Dunn, Timothy C. Hetherington, Jennifer Priem, Paola Castri, William H. Lagarde, Michael Gibbs, Amina Ahmed, and The COVID-19 Community Research Partnership
- Subjects
COVID-19 ,Social vulnerability index ,Pediatrics ,Masking ,Infection prevention ,Public health ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Individuals with high social vulnerability index (SVI) have poorer outcomes with COVID-19. Masking reduces transmission of COVID-19 among children, but how SVI plays a role in masking behavior is unknown. We aimed to measure the association of SVI with masking adherence among children during the COVID-19 pandemic. Methods We conducted a multi-site, prospective syndromic surveillance study among children aged 2 – 17 years in the Southeastern United States by daily electronic surveys which solicited symptoms of COVID-19-like illness, infection with or exposure to SARS-CoV-2, masking habits, and any receipt of COVID-19 vaccines. Parents/guardians submitted surveys for their children; adolescents 13 years and older could opt to submit their own surveys. Multivariable and univariate linear models were used to measure the associations of different predictors such as SVI with masking adherence. Results One thousand four hundred sixty-one children from 6 states and 55 counties predominately from North and South Carolina were included in the analysis. Most children in the cohort were 5 – 11 years old, non-Hispanic White, from urban counties, and with low-moderate SVI. Overall masking adherence decreased over time, and older children had higher masking adherence throughout the study period compared with younger children. Children who resided in urban counties had greater masking adherence throughout the study period than those who resided in suburban or rural counties. Masking adherence was higher among children with both low and medium SVI than those with high SVI. Conclusions Despite being at risk for more severe outcomes with COVID-19, children with high SVI had lower levels of masking adherence compared to those with low SVI. Our findings highlight opportunities for improved and targeted messaging in these vulnerable communities.
- Published
- 2024
- Full Text
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