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In 31 rabbits the authors studied the systolic blood-pressure, the intraocular pressure and the aqueous humour outflow during althesine-monoanaesthesia. While the systolic blood-pressure decreased, the intraocular pressure increased during anaesthesia. The increase in the intraocular pressure was accompanied by an increase in the outflow facility. The results in relation to the circulatory effects of althesine agreed with the published data, but the increase in the intraocular pressure was at divergence with the findings hitherto reported in publications. On the basis of this experimental data care has to be taken in clinical practice when glaucomatous patients are anaesthetized with althesine.