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382 results on '"Heshmati, Javad"'

5. The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple sclerosis patients with mild to moderate depressive symptoms: A randomized, triple-blind, placebo-controlled trial

Author

Hajiluian, Ghazaleh, Karegar, Sahar Jafari, Shidfar, Farzad, Aryaeian, Naheed, Salehi, Masoud, Lotfi, Teyebeh, Farhangnia, Pooya, Heshmati, Javad, and Delbandi, Ali-Akbar

Published
2023
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13. Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis.

Author

Alimohammadi‐Kamalabadi, Malek, Ziaei, Somayeh, Hasani, Motahareh, Mohammadi, Shooka, Mehrbod, Milad, Morvaridi, Mehrnaz, Persad, Emma, Belančić, Andrej, Malekahmadi, Mahsa, Estêvão, Maria Dulce da Mota Antunes de Oliveira, Daneshzad, Elnaz, and Heshmati, Javad

Subjects
DIETARY supplements, VITAMIN D, SEROTONIN, AUTISM spectrum disorders, VITAMIN D deficiency
Abstract

Background and Aims: Vitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta‐analysis was to evaluate the effect of vitamin D supplementation on serum serotonin levels. Methods: We conducted a comprehensive search of PubMed, Scopus, Cochrane Central for Randomized Clinical Trials, and Web of Science up to September 2022, without any language restrictions. The effect sizes were calculated using the standard mean difference (SMD) and 95% confidence interval (CI). Results: Six randomized clinical trials involving 356 participants were included in the analysis. Our findings indicated no significant changes in serotonin levels between the intervention and control groups (SMD: 0.24 ng/mL, 95% CI: −0.28, 0.75, p > 0.10). Subgroup analysis also did not reveal any significant changes in serotonin levels among children, participants with autism spectrum disorders, interventions lasting 10 weeks or longer, or those receiving vitamin D doses below 4000 IU/day. Conclusion: Although the results obtained in this systematic review are inconclusive, they support the need for further well‐designed randomized trials to assess the potential role of vitamin D supplementation in regulating serotonin levels and potentially ameliorating depression and related disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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14. A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF).

Author

Ziaei, Somayeh, Mohammadi, Shooka, Hasani, Motahareh, Morvaridi, Mehrnaz, Belančić, Andrej, Daneshzad, Elnaz, Saleh, Saleh A. K., Adly, Heba M., and Heshmati, Javad

Subjects
BRAIN-derived neurotrophic factor, RANDOM effects model, OMEGA-3 fatty acids, FISH oils, RANDOMIZED controlled trials
Abstract

Omega-3 fatty acids (omega-3 FAs) have attracted the attention of researchers because of their influence on circulatory levels of brain-derived neurotrophic factor (BDNF). Our objective was to review systematically and Meta-analyze randomized controlled trials (RCTs) to assess the effects of omega-3 FAs supplementation on serum BDNF concentration. Scopus, PubMed, Web of Science, and Cochrane Library were systematically searched until April 2023. The Cochrane risk of bias assessment tool was utilized to evaluate the quality of the studies. A random-effects model was employed to estimate the overall effect size of BDNF levels, using the Standard Mean Difference (SMD) and a 95% confidence interval (CI). The heterogeneity among the studies was assessed using chi-squared and I2 statistics. A total of 12 studies involving 587 subjects were included. The supplementation of PUFA was found to be associated with a significant increase in serum levels of BNDF in the group receiving the supplements, as compared to the placebo group (SMD: 0.72 pg/mL, 95% CI: 0.28, 1.15; P < 0.001) (I2 = 84.39%, P < 0.001). Sub-group analyses revealed similar findings in trials with fewer than 10 weeks, which utilized both animal (fish oil) and herbal (flaxseed) forms of omega-3 supplements with a high daily dosage of 2000mg. The present systematic review and meta-analysis indicate the efficacy of omega-3 FAs in increasing the serum concentration of BDNF. Therefore, omega-3 FAs should be prioritized as agents for increasing BDNF in interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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47. High-Density Lipoprotein Metabolism and Function in Cardiovascular Diseases: What about Aging and Diet Effects?

Author

Morvaridzadeh, Mojgan, Zoubdane, Nada, Heshmati, Javad, Alami, Mehdi, Berrougui, Hicham, and Khalil, Abdelouahed

Abstract

Cardiovascular diseases (CVDs) have become the leading global cause of mortality, prompting a heightened focus on identifying precise indicators for their assessment and treatment. In this perspective, the plasma levels of HDL have emerged as a pivotal focus, given the demonstrable correlation between plasma levels and cardiovascular events, rendering them a noteworthy biomarker. However, it is crucial to acknowledge that HDLs, while intricate, are not presently a direct therapeutic target, necessitating a more nuanced understanding of their dynamic remodeling throughout their life cycle. HDLs exhibit several anti-atherosclerotic properties that define their functionality. This functionality of HDLs, which is independent of their concentration, may be impaired in certain risk factors for CVD. Moreover, because HDLs are dynamic parameters, in which HDL particles present different atheroprotective properties, it remains difficult to interpret the association between HDL level and CVD risk. Besides the antioxidant and anti-inflammatory activities of HDLs, their capacity to mediate cholesterol efflux, a key metric of HDL functionality, represents the main anti-atherosclerotic property of HDL. In this review, we will discuss the HDL components and HDL structure that may affect their functionality and we will review the mechanism by which HDL mediates cholesterol efflux. We will give a brief examination of the effects of aging and diet on HDL structure and function. [ABSTRACT FROM AUTHOR]

Published
2024
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