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1. TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia

Author

Bröker-Lai, Jenny, Rego Terol, José, Richter, Christin, Mathar, Ilka, Wirth, Angela, Kopf, Stefan, Moreno-Pérez, Ana, Büttner, Michael, Tan, Linette Liqi, Makke, Mazen, Poschet, Gernot, Hermann, Julia, Tsvilovskyy, Volodymyr, Haberkorn, Uwe, Wartenberg, Philipp, Susperreguy, Sebastian, Berlin, Michael, Ottenheijm, Roger, Philippaert, Koenraad, Wu, Moya, Wiedemann, Tobias, Herzig, Stephan, Belkacemi, Anouar, Levinson, Rebecca T, Agarwal, Nitin, Camacho Londoño, Juan E, Klebl, Bert, Dinkel, Klaus, Zufall, Frank, Nussbaumer, Peter, Boehm, Ulrich, Hell, Rüdiger, Nawroth, Peter, Birnbaumer, Lutz, Leinders-Zufall, Trese, Kuner, Rohini, Zorn, Markus, Bruns, Dieter, Schwarz, Yvonne, and Freichel, Marc

Published
2024
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2. Virtual reality-empowered deep-learning analysis of brain cells

Author

Kaltenecker, Doris, Al-Maskari, Rami, Negwer, Moritz, Hoeher, Luciano, Kofler, Florian, Zhao, Shan, Todorov, Mihail, Rong, Zhouyi, Paetzold, Johannes Christian, Wiestler, Benedikt, Piraud, Marie, Rueckert, Daniel, Geppert, Julia, Morigny, Pauline, Rohm, Maria, Menze, Bjoern H., Herzig, Stephan, Berriel Diaz, Mauricio, and Ertürk, Ali

Published
2024
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3. CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes

Author

Schnell, Oliver, Barnard-Kelly, Katharine, Battelino, Tadej, Ceriello, Antonio, Larsson, Helena Elding, Fernández-Fernández, Beatriz, Forst, Thomas, Frias, Juan-Pablo, Gavin, III, James R., Giorgino, Francesco, Groop, Per-Henrik, Heerspink, Hiddo J. L., Herzig, Stephan, Hummel, Michael, Huntley, George, Ibrahim, Mahmoud, Itzhak, Baruch, Jacob, Stephan, Ji, Linong, Kosiborod, Mikhail, Lalic, Nebosja, Macieira, Sofia, Malik, Rayaz A., Mankovsky, Boris, Marx, Nikolaus, Mathieu, Chantal, Müller, Timo D., Ray, Kausik, Rodbard, Helena W., Rossing, Peter, Rydén, Lars, Schumm-Draeger, Petra-Maria, Schwarz, Peter, Škrha, Jan, Snoek, Frank, Tacke, Frank, Taylor, Bruce, Jeppesen, Britta Tendal, Tesfaye, Solomon, Topsever, Pinar, Vilsbøll, Tina, Yu, Xuefeng, and Standl, Eberhard

Published
2024
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4. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Author

Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J. R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, and Prokesch, Andreas

Published
2024
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7. Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia

Author

Taylor, Jacqueline, Uhl, Leonie, Moll, Iris, Hasan, Sana Safatul, Wiedmann, Lena, Morgenstern, Jakob, Giaimo, Benedetto Daniele, Friedrich, Tobias, Alsina-Sanchis, Elisenda, De Angelis Rigotti, Francesca, Mülfarth, Ronja, Kaltenbach, Sarah, Schenk, Darius, Nickel, Felix, Fleming, Thomas, Sprinzak, David, Mogler, Carolin, Korff, Thomas, Billeter, Adrian T., Müller-Stich, Beat P., Berriel Diaz, Mauricio, Borggrefe, Tilman, Herzig, Stephan, Rohm, Maria, Rodriguez-Vita, Juan, and Fischer, Andreas

Published
2023
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9. Nuclear Receptors in Energy Metabolism

Author

Walth-Hummel, Alina A., Herzig, Stephan, Rohm, Maria, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Campbell, Moray J., editor, and Bevan, Charlotte L., editor

Published
2022
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11. Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner

Author

Wang, Yong, primary, Li, Guo, additional, Chen, Bingni, additional, Shakir, George, additional, Volz, Mario, additional, van der Vorst, Emiel P C, additional, Maas, Sanne L, additional, Geiger, Martina, additional, Jethwa, Carolin, additional, Bartelt, Alexander, additional, Li, Zhaolong, additional, Wettich, Justus, additional, Sachs, Nadja, additional, Maegdefessel, Lars, additional, Nazari Jahantigh, Maliheh, additional, Hristov, Michael, additional, Lacy, Michael, additional, Lutz, Beat, additional, Weber, Christian, additional, Herzig, Stephan, additional, Guillamat Prats, Raquel, additional, and Steffens, Sabine, additional

Published
2024
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12. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Author

Quarta, Carmelo, Stemmer, Kerstin, Novikoff, Aaron, Yang, Bin, Klingelhuber, Felix, Harger, Alex, Bakhti, Mostafa, Bastidas-Ponce, Aimee, Baugé, Eric, Campbell, Jonathan E., Capozzi, Megan, Clemmensen, Christoffer, Collden, Gustav, Cota, Perla, Douros, Jon, Drucker, Daniel J., DuBois, Barent, Feuchtinger, Annette, Garcia-Caceres, Cristina, Grandl, Gerald, Hennuyer, Nathalie, Herzig, Stephan, Hofmann, Susanna M., Knerr, Patrick J., Kulaj, Konxhe, Lalloyer, Fanny, Lickert, Heiko, Liskiewicz, Arek, Liskiewicz, Daniela, Maity, Gandhari, Perez-Tilve, Diego, Prakash, Sneha, Sanchez-Garrido, Miguel A., Zhang, Qian, Staels, Bart, Krahmer, Natalie, DiMarchi, Richard D., Tschöp, Matthias H., Finan, Brian, and Müller, Timo D.

Published
2022
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13. Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Author

Sekar, Revathi, Motzler, Karsten, Kwon, Yun, Novikoff, Aaron, Jülg, Julia, Najafi, Bahar, Wang, Surui, Warnke, Anna-Luisa, Seitz, Susanne, Hass, Daniela, Gancheva, Sofiya, Kahl, Sabine, Yang, Bin, Finan, Brian, Schwarz, Kathrin, Okun, Juergen G., Roden, Michael, Blüher, Matthias, Müller, Timo D., Krahmer, Natalie, Behrends, Christian, Plettenburg, Oliver, Miaczynska, Marta, Herzig, Stephan, and Zeigerer, Anja

Published
2022
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14. Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

Author

Wolff, Gretchen, Sakurai, Minako, Mhamane, Amit, Troullinaki, Maria, Maida, Adriano, Deligiannis, Ioannis K., Yin, Kelvin, Weber, Peter, Morgenstern, Jakob, Wieder, Annika, Kwon, Yun, Sekar, Revathi, Zeigerer, Anja, Roden, Michael, Blüher, Matthias, Volk, Nadine, Poth, Tanja, Hackert, Thilo, Wiedmann, Lena, De Angelis Rigotti, Francesca, Rodriguez-Vita, Juan, Fischer, Andreas, Mukthavaram, Rajesh, Limphong, Pattraranee, Tachikawa, Kiyoshi, Karmali, Priya, Payne, Joseph, Chivukula, Padmanabh, Ekim-Üstünel, Bilgen, Martinez-Jimenez, Celia P., Szendrödi, Julia, Nawroth, Peter, and Herzig, Stephan

Published
2022
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15. Sexual dimorphism in COVID-19: potential clinical and public health implications

Author

Bechmann, Nicole, Barthel, Andreas, Schedl, Andreas, Herzig, Stephan, Varga, Zsuzsanna, Gebhard, Catherine, Mayr, Manuel, Hantel, Constanze, Beuschlein, Felix, Wolfrum, Christian, Perakakis, Nikolaos, Poston, Lucilla, Andoniadou, Cynthia L, Siow, Richard, Gainetdinov, Raul R, Dotan, Arad, Shoenfeld, Yehuda, Mingrone, Geltrude, and Bornstein, Stefan R

Published
2022
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16. A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

Author

Loft, Anne, Schmidt, Søren Fisker, Caratti, Giorgio, Stifel, Ulrich, Havelund, Jesper, Sekar, Revathi, Kwon, Yun, Sulaj, Alba, Chow, Kan Kau, Alfaro, Ana Jimena, Schwarzmayr, Thomas, Rittig, Nikolaj, Svart, Mads, Tsokanos, Foivos-Filippos, Maida, Adriano, Blutke, Andreas, Feuchtinger, Annette, Møller, Niels, Blüher, Matthias, Nawroth, Peter, Szendrödi, Julia, Færgeman, Nils J., Zeigerer, Anja, Tuckermann, Jan, and Herzig, Stephan

Published
2022
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17. Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus.

Author

Schimpfle, Lukas, Tsilingiris, Dimitrios, Mooshage, Christoph M, Kender, Zoltan, Sulaj, Alba, Rauchhaupt, Ekatherina von, Szendroedi, Julia, Herzig, Stephan, Goepfert, Jens, Groener, Jan, Nawroth, Peter P, Bendszus, Martin, Heiland, Sabine, Kurz, Felix T, Jende, Johann M E, and Kopf, Stefan

Subjects
MAGNETIC resonance neurography, NERVE conduction studies, TYPE 2 diabetes, BIOELECTRIC impedance, PERIPHERAL nervous system
Abstract

Context Due to the heterogenous clinical symptoms and deficits, the diagnosis of diabetic polyneuropathy (DPN) is still difficult in clinical routines, leading to increased morbidity and mortality. Objective We studied the correlation of phase angle (PhA) of bioelectrical impedance analysis (BIA) with clinical, laboratory, and physical markers of DPN to evaluate PhA as a possible diagnostic method for DPN. Materials and methods In this cross-sectional observational study as part of the Heidelberg Study on Diabetes and Complications, we examined 104 healthy individuals and 205 patients with type 2 diabetes mellitus (T2D), among which 63 had DPN. The PhA was calculated from multifrequency BIA. Nerve conduction studies, quantitative sensory testing (QST) and diffusion-weighted magnetic resonance neurography to determine fractional anisotropy (FA) reflecting peripheral nerve integrity were performed. Results T2D patients with DPN had lower PhA values (5.71 ± 0.10) compared to T2D patients without DPN (6.07 ± 0.08, P =.007, + 6.1%) and healthy controls (6.18 ± 0.08, P <.001, + 7.9%). Confounder-adjusted analyses showed correlations of the PhA with conduction velocities and amplitudes of the peroneal (β=.28; β=.31, P <.001) and tibial nerves (β=.28; β=.32, P <.001), Z-scores of QST (thermal detection β=.30, P <.05) and the FA (β=.60, P <.001). Receiver-operating characteristic analysis showed similar performance of PhA in comparison to the mentioned diagnostic methods. Conclusion The study shows that PhA is, in comparison to other test systems used, at least an equally good and much easier to handle investigator-independent marker for detection of DPN. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Targeted modulation of gene expression through receptor‐specific delivery of small interfering RNA peptide conjugates.

Author

Schenk, Mareike, Mörl, Karin, Herzig, Stephan, and Beck‐Sickinger, Annette G.

Abstract

Small interfering RNA (siRNA) has emerged as a valuable tool to address RNA interference (RNAi) to modulate gene expression also in therapy. However, challenges such as inefficient cell targeting and rapid degradation in biological systems have limited its success. To address these issues, the development of a receptor‐specific shuttle system represents a promising solution. [F7,P34]‐NPY analogues were modified by solid‐phase peptide synthesis, enabling non‐covalent conjugation with siRNA. This modification yielded an efficient siRNA vehicle capable of binding and transporting its cargo into target cells without adversely affecting receptor activation or cell viability. Mass spectrometry and gel shift assays confirmed successful and stable siRNA binding under various conditions. Microscopy experiments further demonstrated the co‐internalization of labeled peptides and siRNA in Hepa1c1 cells, highlighting the stability of the complex. In vitro quantitative RT‐PCR experiments, targeting the TSC22D4 gene to normalize systemic glucose homeostasis and insulin resistance, revealed a functional peptide‐based siRNA shuttle system with the ability to decrease mRNA expression to approximately 40%. These findings strengthen the potential of receptor‐specific siRNA shuttle systems as efficient tools for gene therapy that offer a possibility for reducing side effects. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Functional redundancy between glucocorticoid and mineralocorticoid receptors in mature corticotropin‐releasing hormone neurons protects from obesity.

Author

Liu, Yu, Lin, Dongfa, Najam, Syeda Sadia, Huang, Shangyuan, Song, Muyi, Sirakawin, Chaweewan, Zhao, Catherine, Jiang, Haixia, Konopka, Witold, Herzig, Stephan, and Vinnikov, Ilya A.

Subjects
MINERALOCORTICOID receptors, GLUCOCORTICOID receptors, NEURON analysis, INSULIN sensitivity, PROTEIN-tyrosine kinases
Abstract

Objective: Here, we aimed to investigate the role of glucocorticoid and mineralocorticoid receptors (GRs and MRs, respectively) in the regulation of energy homeostasis. Methods: We used three mouse models with simultaneous deletion of GRs and MRs in either forebrain neurons, the paraventricular nucleus, or corticotropin‐releasing hormone (CRH) neurons and compared them with wild‐type controls or isolated knockout groups. In addition to body weight, food intake, energy expenditure, insulin sensitivity, fat/lean mass distribution, and plasma corticosterone levels, we also performed transcriptomic analysis of CRH neurons and assessed their response to melanocortinergic stimulation. Results: Similar to global double‐knockout models, deletion of GRs and MRs specifically in mature CRH neurons resulted in obesity. Importantly, the latter was accompanied by insulin resistance, but not increased plasma corticosterone levels. Transcriptomic analysis of these neurons revealed upregulation of several genes involved in postsynaptic signal transduction, including the Ptk2b gene, which encodes proline‐rich tyrosine kinase 2. Knockout of both nuclear receptors leads to upregulation of Ptk2b in CRH neurons, which results in their diminished responsiveness to melanocortinergic stimulation. Conclusions: Our data demonstrate the functional redundancy of GRs and MRs in CRH neurons to maintain energy homeostasis and prevent obesity. Simultaneous targeting of both receptors might represent an unprecedented approach to counteract obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Glucose Load Following Prolonged Fasting Increases Oxidative Stress– Linked Response in Individuals With Diabetic Complications.

Author

von Rauchhaupt, Ekaterina, Rodemer, Claus, Kliemank, Elisabeth, Bulkescher, Ruben, Campos, Marta, Kopf, Stefan, Fleming, Thomas, Herzig, Stephan, Nawroth, Peter P., Szendroedi, Julia, Zemva, Johanna, and Sulaj, Alba

Subjects
MONONUCLEAR leukocytes, TYPE 2 diabetes, CITRATE synthase, DIABETES complications, GENE expression, GLUCOSE tolerance tests
Abstract

OBJECTIVE: Prolonged catabolic states in type 2 diabetes (T2D), exacerbated by excess substrate flux and hyperglycemia, can challenge metabolic flexibility and antioxidative capacity. We investigated cellular responses to glucose load after prolonged fasting in T2D. RESEARCH DESIGN AND METHODS: Glucose-tolerant individuals (CON, n = 10) and individuals with T2D with (T2D+, n = 10) and without (T2D−, n = 10) diabetes complications underwent oral glucose tolerance test before and after a 5-day fasting-mimicking diet. Peripheral blood mononuclear cell (PBMC) resistance to ex vivo dicarbonyl methylglyoxal (MG) exposure after glucose load was assessed. Markers of dicarbonyl detoxification, oxidative stress, and mitochondrial biogenesis were analyzed by quantitative PCR, with mitochondrial complex protein expression assessed by Western blotting. RESULTS: T2D+ exhibited decreased PBMC resistance against MG, while T2D− resistance remained unchanged, and CON improved postglucose load and fasting (−19.0% vs. −1.7% vs. 12.6%; all P = 0.017). T2D+ showed increased expression in dicarbonyl detoxification (mRNA glyoxalase-1, all P = 0.039), oxidative stress (mRNA glutathione-disulfide-reductase, all P = 0.006), and mitochondrial complex V protein (all P = 0.004) compared with T2D− and CON postglucose load and fasting. Citrate synthase activity remained unchanged, indicating no change in mitochondrial number. Mitochondrial biogenesis increased in T2D− compared with CON postglucose load and fasting (mRNA HspA9, P = 0.032). T2D−, compared with CON, exhibited increased oxidative stress postfasting, but not postglucose load, with increased mRNA expression in antioxidant defenses (mRNA forkhead box O4, P = 0.036, and glutathione-peroxidase-2, P = 0.034), and compared with T2D+ (glutathione-peroxidase-2, P = 0.04). CONCLUSIONS: These findings suggest increased susceptibility to glucose-induced oxidative stress in individuals with diabetes complications after prolonged fasting and might help in diet interventions for diabetes management. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Author

Loft, Anne, Alfaro, Ana Jimena, Schmidt, Søren Fisker, Pedersen, Felix Boel, Terkelsen, Mike Krogh, Puglia, Michele, Chow, Kan Kau, Feuchtinger, Annette, Troullinaki, Maria, Maida, Adriano, Wolff, Gretchen, Sakurai, Minako, Berutti, Riccardo, Ekim Üstünel, Bilgen, Nawroth, Peter, Ravnskjaer, Kim, Diaz, Mauricio Berriel, Blagoev, Blagoy, and Herzig, Stephan

Published
2021
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25. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Author

Zhang, Qian, Delessa, Challa Tenagne, Augustin, Robert, Bakhti, Mostafa, Colldén, Gustav, Drucker, Daniel J., Feuchtinger, Annette, Caceres, Cristina Garcia, Grandl, Gerald, Harger, Alexandra, Herzig, Stephan, Hofmann, Susanna, Holleman, Cassie Lynn, Jastroch, Martin, Keipert, Susanne, Kleinert, Maximilian, Knerr, Patrick J., Kulaj, Konxhe, Legutko, Beata, Lickert, Heiko, Liu, Xue, Luippold, Gerd, Lutter, Dominik, Malogajski, Emilija, Medina, Marta Tarquis, Mowery, Stephanie A., Blutke, Andreas, Perez-Tilve, Diego, Salinno, Ciro, Sehrer, Laura, DiMarchi, Richard D., Tschöp, Matthias H., Stemmer, Kerstin, Finan, Brian, Wolfrum, Christian, and Müller, Timo D.

Published
2021
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26. HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling

Author

Giroud, Maude, Tsokanos, Foivos-Filippos, Caratti, Giorgio, Kotschi, Stefan, Khani, Sajjad, Jouffe, Céline, Vogl, Elena S., Irmler, Martin, Glantschnig, Christina, Gil-Lozano, Manuel, Hass, Daniela, Khan, Asrar Ali, Garcia, Marcos Rios, Mattijssen, Frits, Maida, Adriano, Tews, Daniel, Fischer-Posovszky, Pamela, Feuchtinger, Annette, Virtanen, Kirsi A., Beckers, Johannes, Wabitsch, Martin, Uhlenhaut, Henriette, Blüher, Matthias, Tuckermann, Jan, Scheideler, Marcel, Bartelt, Alexander, and Herzig, Stephan

Published
2021
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27. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Author

Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J.R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, Prokesch, Andreas, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J.R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, and Prokesch, Andreas

Published
2024

28. CVOT Summit Report 2023:new cardiovascular, kidney, and metabolic outcomes

Author

Schnell, Oliver, Barnard-Kelly, Katharine, Battelino, Tadej, Ceriello, Antonio, Larsson, Helena Elding, Fernández-Fernández, Beatriz, Forst, Thomas, Frias, Juan Pablo, Gavin, James R., Giorgino, Francesco, Groop, Per Henrik, Heerspink, Hiddo J.L., Herzig, Stephan, Hummel, Michael, Huntley, George, Ibrahim, Mahmoud, Itzhak, Baruch, Jacob, Stephan, Ji, Linong, Kosiborod, Mikhail, Lalic, Nebosja, Macieira, Sofia, Malik, Rayaz A., Mankovsky, Boris, Marx, Nikolaus, Mathieu, Chantal, Müller, Timo D., Ray, Kausik, Rodbard, Helena W., Rossing, Peter, Rydén, Lars, Schumm-Draeger, Petra Maria, Schwarz, Peter, Škrha, Jan, Snoek, Frank, Tacke, Frank, Taylor, Bruce, Jeppesen, Britta Tendal, Tesfaye, Solomon, Topsever, Pinar, Vilsbøll, Tina, Yu, Xuefeng, Standl, Eberhard, Schnell, Oliver, Barnard-Kelly, Katharine, Battelino, Tadej, Ceriello, Antonio, Larsson, Helena Elding, Fernández-Fernández, Beatriz, Forst, Thomas, Frias, Juan Pablo, Gavin, James R., Giorgino, Francesco, Groop, Per Henrik, Heerspink, Hiddo J.L., Herzig, Stephan, Hummel, Michael, Huntley, George, Ibrahim, Mahmoud, Itzhak, Baruch, Jacob, Stephan, Ji, Linong, Kosiborod, Mikhail, Lalic, Nebosja, Macieira, Sofia, Malik, Rayaz A., Mankovsky, Boris, Marx, Nikolaus, Mathieu, Chantal, Müller, Timo D., Ray, Kausik, Rodbard, Helena W., Rossing, Peter, Rydén, Lars, Schumm-Draeger, Petra Maria, Schwarz, Peter, Škrha, Jan, Snoek, Frank, Tacke, Frank, Taylor, Bruce, Jeppesen, Britta Tendal, Tesfaye, Solomon, Topsever, Pinar, Vilsbøll, Tina, Yu, Xuefeng, and Standl, Eberhard

Abstract

The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT and STEP-HFpEF) and bempedoic acid (CLEAR Outcomes), and the advances they represent in reducing the risk of major adverse cardiovascular events (MACE), improving metabolic outcomes, and treating obesity-related heart failure with preserved ejection fraction (HFpEF). A broad audience of endocrinologists, diabetologists, cardiologists, nephrologists and primary care physicians participated in online discussions on guideline updates for the management of cardiovascular disease (CVD) in diabetes, heart failure (HF) and chronic kidney disease (CKD); advances in the management of type 1 diabetes (T1D) and its comorbidities; advances in the management of CKD with SGLT2 inhibitors and non-steroidal mineralocorticoid receptor antagonists (nsMRAs); and advances in the treatment of obesity with GLP-1 and dual GIP/GLP-1 receptor agonists. The association of diabetes and obesity with nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis, MASH) and cancer and possible treatments for these complications were also explored. It is generally assumed that treatment of chronic diseases is equally effective for all patients. However, as discussed at the Summit, this assumption may not be true. Therefore, it is important to enroll patients from diverse racial and ethnic groups in clinical trials and to analyze patient-reported outcomes to assess treatment efficacy, and to develop innovative approaches to tailor medications to those who benefit most with minimal side effects. Other keys to a successful management of diabetes and comorbidities, including dementia, entail the use of continuous glucose monitoring (CGM) technolo, The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT and STEP-HFpEF) and bempedoic acid (CLEAR Outcomes), and the advances they represent in reducing the risk of major adverse cardiovascular events (MACE), improving metabolic outcomes, and treating obesity-related heart failure with preserved ejection fraction (HFpEF). A broad audience of endocrinologists, diabetologists, cardiologists, nephrologists and primary care physicians participated in online discussions on guideline updates for the management of cardiovascular disease (CVD) in diabetes, heart failure (HF) and chronic kidney disease (CKD); advances in the management of type 1 diabetes (T1D) and its comorbidities; advances in the management of CKD with SGLT2 inhibitors and non-steroidal mineralocorticoid receptor antagonists (nsMRAs); and advances in the treatment of obesity with GLP-1 and dual GIP/GLP-1 receptor agonists. The association of diabetes and obesity with nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis, MASH) and cancer and possible treatments for these complications were also explored. It is generally assumed that treatment of chronic diseases is equally effective for all patients. However, as discussed at the Summit, this assumption may not be true. Therefore, it is important to enroll patients from diverse racial and ethnic groups in clinical trials and to analyze patient-reported outcomes to assess treatment efficacy, and to develop innovative approaches to tailor medications to those who benefit most with minimal side effects. Other keys to a successful management of diabetes and comorbidities, including dementia, entail the use of continuous glucose monitoring (CGM) techn

Published
2024

29. Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes

Author

Okun, Jürgen G., Rusu, Patricia M., Chan, Andrea Y., Wu, Yuqin, Yap, Yann W., Sharkie, Thomas, Schumacher, Jonas, Schmidt, Kathrin V., Roberts-Thomson, Katherine M., Russell, Ryan D., Zota, Annika, Hille, Susanne, Jungmann, Andreas, Maggi, Ludovico, Lee, Young, Blüher, Matthias, Herzig, Stephan, Keske, Michelle A., Heikenwalder, Mathias, Müller, Oliver J., and Rose, Adam J.

Published
2021
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30. Angpt2/Tie2 autostimulatory loop controls tumorigenesis

Author

Karabid, Ninelia Minaskan, Wiedemann, Tobias, Gulde, Sebastian, Mohr, Hermine, Segaran, Renu Chandra, Geppert, Julia, Rohm, Maria, Vitale, Giovanni, Gaudenzi, Germano, Dicitore, Alessandra, Ankerst, Donna Pauler, Chen, Yiyao, Braren, Rickmer, Kaissis, Georg, Schilling, Franz, Schillmaier, Mathias, Eisenhofer, Graeme, Herzig, Stephan, Roncaroli, Federico, Honegger, Jürgen B, and Pellegata, Natalia S

Published
2022
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34. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

Author

Georgiadi, Anastasia, Lopez-Salazar, Valeria, Merahbi, Rabih El-, Karikari, Rhoda Anane, Ma, Xiaochuan, Mourão, André, Klepac, Katarina, Bühler, Lea, Alfaro, Ana Jimena, Kaczmarek, Isabell, Linford, Adam, Bosma, Madeleen, Shilkova, Olga, Ritvos, Olli, Nakamura, Nobuhiro, Hirose, Shigehisa, Lassi, Maximilian, Teperino, Raffaele, Machado, Juliano, Scheideler, Marcel, Dietrich, Arne, Geerlof, Arie, Feuchtinger, Annette, Blutke, Andreas, Fischer, Katrin, Müller, Timo Dirk, Kessler, Katharina, Schöneberg, Torsten, Thor, Doreen, Hornemann, Silke, Kruse, Michael, Nawroth, Peter, Pivovarova-Ramich, Olga, Pfeiffer, Andreas Friedrich Hermann, Sattler, Michael, Blüher, Matthias, and Herzig, Stephan

Published
2021
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36. O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Author

Gonzalez-Rellan, Maria J., Fondevila, Marcos F., Fernandez, Uxia, Rodríguez, Amaia, Varela-Rey, Marta, Veyrat-Durebex, Christelle, Seoane, Samuel, Bernardo, Ganeko, Lopitz-Otsoa, Fernando, Fernández-Ramos, David, Bilbao, Jon, Iglesias, Cristina, Novoa, Eva, Ameneiro, Cristina, Senra, Ana, Beiroa, Daniel, Cuñarro, Juan, DP Chantada-Vazquez, Maria, Garcia-Vence, Maria, Bravo, Susana B., Da Silva Lima, Natalia, Porteiro, Begoña, Carneiro, Carmen, Vidal, Anxo, Tovar, Sulay, Müller, Timo D., Ferno, Johan, Guallar, Diana, Fidalgo, Miguel, Sabio, Guadalupe, Herzig, Stephan, Yang, Won Ho, Cho, Jin Won, Martinez-Chantar, Maria Luz, Perez-Fernandez, Roman, López, Miguel, Dieguez, Carlos, Mato, Jose M., Millet, Oscar, Coppari, Roberto, Woodhoo, Ashwin, Fruhbeck, Gema, and Nogueiras, Ruben

Published
2021
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39. Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice

Author

Görgülü, Kivanc, Diakopoulos, Kalliope N., Ai, Jiaoyu, Schoeps, Benjamin, Kabacaoglu, Derya, Karpathaki, Angeliki-Faidra, Ciecielski, Katrin J., Kaya-Aksoy, Ezgi, Ruess, Dietrich A., Berninger, Alexandra, Kowalska, Marlena, Stevanovic, Marija, Wörmann, Sonja M., Wartmann, Thomas, Zhao, Yue, Halangk, Walter, Voronina, Svetlana, Tepikin, Alexey, Schlitter, Anna Melissa, Steiger, Katja, Artati, Anna, Adamski, Jerzy, Aichler, Michaela, Walch, Axel, Jastroch, Martin, Hartleben, Götz, Mantzoros, Christos S., Weichert, Wilko, Schmid, Roland M., Herzig, Stephan, Krüger, Achim, Sainz, Bruno, Jr., Lesina, Marina, and Algül, Hana

Published
2019
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41. A diminished sciatic nerve structural integrity is associated with distinct peripheral sensory phenotypes in individuals with type 2 diabetes

Author

Mooshage, Christoph M., primary, Tsilingiris, Dimitrios, additional, Schimpfle, Lukas, additional, Seebauer, Lukas, additional, Eldesouky, Omar, additional, Aziz-Safaie, Taraneh, additional, Hohmann, Anja, additional, Herzig, Stephan, additional, Szendroedi, Julia, additional, Nawroth, Peter, additional, Heiland, Sabine, additional, Bendszus, Martin, additional, Kurz, Felix T., additional, Kopf, Stefan, additional, Jende, Johann M. E., additional, and Kender, Zoltan, additional

Published
2023
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43. The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes

Author

Giroud, Maude, primary, Kotschi, Stefan, additional, Kwon, Yun, additional, Le Thuc, Ophélia, additional, Hoffmann, Anne, additional, Gil‐Lozano, Manuel, additional, Karbiener, Michael, additional, Higareda‐Almaraz, Juan Carlos, additional, Khani, Sajjad, additional, Tews, Daniel, additional, Fischer‐Posovszky, Pamela, additional, Sun, Wenfei, additional, Dong, Hua, additional, Ghosh, Adhideb, additional, Wolfrum, Christian, additional, Wabitsch, Martin, additional, Virtanen, Kirsi A, additional, Blüher, Matthias, additional, Nielsen, Søren, additional, Zeigerer, Anja, additional, García‐Cáceres, Cristina, additional, Scheideler, Marcel, additional, Herzig, Stephan, additional, and Bartelt, Alexander, additional

Published
2023
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44. Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Author

Hartleben, Goetz, Schorpp, Kenji, Kwon, Yun, Betz, Barbara, Tsokanos, Foivos‐Filippos, Dantes, Zahra, Schäfer, Arlett, Rothenaigner, Ina, Monroy Kuhn, José Manuel, Morigny, Pauline, Mehr, Lisa, Lin, Sean, Seitz, Susanne, Tokarz, Janina, Artati, Anna, Adamsky, Jerzy, Plettenburg, Oliver, Lutter, Dominik, Irmler, Martin, Beckers, Johannes, Reichert, Maximilian, Hadian, Kamyar, Zeigerer, Anja, Herzig, Stephan, and Berriel Diaz, Mauricio

Published
2021
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45. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

Author

Seitz, Susanne, Kwon, Yun, Hartleben, Götz, Jülg, Julia, Sekar, Revathi, Krahmer, Natalie, Najafi, Bahar, Loft, Anne, Gancheva, Sofiya, Stemmer, Kerstin, Feuchtinger, Annette, Hrabe de Angelis, Martin, Müller, Timo D., Mann, Matthias, Blüher, Matthias, Roden, Michael, Berriel Diaz, Mauricio, Behrends, Christian, Gilleron, Jerome, Herzig, Stephan, and Zeigerer, Anja

Published
2019
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48. Fasting‐sensitive SUMO‐switch on Prox1 controls hepatic cholesterol metabolism

Author

Alfaro, Ana Jimena, primary, Dittner, Claudia, additional, Becker, Janina, additional, Loft, Anne, additional, Mhamane, Amit, additional, Maida, Adriano, additional, Georgiadi, Anastasia, additional, Tsokanos, Foivos‐Filippos, additional, Klepac, Katarina, additional, Molocea, Claudia‐Eveline, additional, El‐Merahbi, Rabih, additional, Motzler, Karsten, additional, Geppert, Julia, additional, Karikari, Rhoda Anane, additional, Szendrödi, Julia, additional, Feuchtinger, Annette, additional, Hofmann, Susanna, additional, Karaca, Samir, additional, Urlaub, Henning, additional, Berriel Diaz, Mauricio, additional, Melchior, Frauke, additional, and Herzig, Stephan, additional

Published
2023
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49. Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity

Author

Bartelt, Alexander, primary, Lemmer, Imke, additional, Willemsen, Nienke, additional, Kotschi, Stefan, additional, Toksöz, Irmak, additional, Gjika, Ejona, additional, Khani, Sajjad, additional, Haas, Daniel, additional, Krahmer, Natalie, additional, Rohm, Maria, additional, Dyar, Kenneth, additional, Herzig, Stephan, additional, Diercksen, Nick, additional, Nguyen, Phong, additional, Menden, Michael, additional, Egu, Desalegn, additional, Waschke, Jens, additional, Larsen, Steen, additional, Ma, Tao, additional, and Gerhart-Hines, Zachary, additional

Published
2023
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50. Adipocyte p53 coordinates the response to cyclic fasting by regulating adipose tissue immune cell landscape

Author

Prokesch, Andreas, primary, Reinisch, Isabel, additional, Michenthaler, Helene, additional, Moyschewitz, Elisabeth, additional, Krstic, Jelena, additional, Galhuber, Markus, additional, Wang, Tongtong, additional, Vujic, Nemanja, additional, Amor, Melina, additional, Chiozzi, Riccardo Zenezini, additional, Wabitsch, Martin, additional, Kolb, Dagmar, additional, Georgiadi, Anastasia, additional, Glawitsch, Lisa, additional, Heitzer, Ellen, additional, Schulz, Tim, additional, Schupp, Michael, additional, Sun, Wenfei, additional, Dong, Hua, additional, Ghosh, Adhideb, additional, Kratky, Dagmar, additional, Heck, Albert, additional, Sulaj, Alba, additional, Blüher, Matthias, additional, Hoffmann, Anne, additional, Herzig, Stephan, additional, and Wolfrum, Christian, additional

Published
2023
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