44 results on '"Herz-Ruelas ME"'
Search Results
2. Hair Disorders in Autoimmune Diseases.
- Author
-
Rodríguez-Tamez G, Herz-Ruelas ME, Gómez-Flores M, Ocampo-Candiani J, and Chavez-Alvarez S
- Abstract
Alopecia is a common feature in several autoimmune diseases. With a wide spectrum of clinical presentations, it may manifest with a scarring or non-scarring nature, in a diffuse, patchy, or localized pattern. We as dermatologists have the opportunity of assessing patients with hair loss who may have an underlying undiagnosed autoimmune disorder. This review aimed to describe the main clinical, trichoscopic, and histopathological features of hair disorders associated with autoimmune diseases., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2023 by S. Karger AG, Basel.)
- Published
- 2023
- Full Text
- View/download PDF
3. A persistent crusted erythematous plaque on the forearm.
- Author
-
Figueroa-Morales AL, Kubelis-López DE, Pérez-Garza DM, Rodríguez-Tamez G, Vázquez-Martínez OT, Ocampo-Candiani J, and Herz-Ruelas ME
- Subjects
- Humans, Erythema diagnosis, Upper Extremity, Forearm, Scabies
- Published
- 2023
- Full Text
- View/download PDF
4. Intermittent Soft-Tissue Tumor Enlargement in Episodic Angioedema With Eosinophilia Syndrome.
- Author
-
Fernández LT, Ocampo-Candiani J, Watts-Santos A, Guerrero-Putz MD, González-Díaz SN, Zárate-Hernández MDC, Cantú-Rodríguez OG, and Herz-Ruelas ME
- Subjects
- Male, Humans, Adult, Fever, Angioedema etiology, Angioedema pathology, Eosinophilia complications, Eosinophilia pathology, Urticaria, Skin Neoplasms
- Abstract
Abstract: Episodic hypereosinophilia and angioedema syndrome, also known as Gleich syndrome, is a rare entity characterized by recurrent episodes of eosinophilia, angioedema, urticaria, fever and weight gain with spontaneous resolution. It is classified as an idiopathic hypereosinophilic syndrome. Unlike other hypereosinophilic syndromes, it has a low risk for internal organ damage. We report the case of a 42-year-old male with a 28-year history of recurrent erythematous wheals and plaques and persistent hypereosinophilia. Physical examination revealed a well-defined subcutaneous nodule on his right lower limb that increased in size with each episode of angioedema. Histopathology evidenced a lipoma with intense eosinophil infiltration within the mature adipose tissue, while the specimen of the wheal revealed scarce perivascular and interstitial eosinophilic inflammatory infiltrate. Diagnosis of episodic angioedema with eosinophilia syndrome was made based on clinical and laboratory findings., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
5. Switching immune sensitizer agents in refractory alopecia areata as a valuable therapeutic strategy a retrospective case series.
- Author
-
Herz-Ruelas ME, Ocampo-Candiani J, Gómez-Flores M, Martínez-Rico JC, Chávez-Alvarez S, and Rivera-Izaguirre BC
- Subjects
- Humans, Retrospective Studies, Alopecia Areata drug therapy
- Published
- 2022
- Full Text
- View/download PDF
6. Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study.
- Author
-
Sánchez-Meza E, Ocampo-Candiani J, Gómez-Flores M, Herz-Ruelas ME, Ocampo-Garza J, Orizaga-Y-Quiroga TL, Martínez-Moreno A, and Ocampo-Garza SS
- Subjects
- Administration, Topical, Double-Blind Method, Dutasteride therapeutic use, Humans, Minoxidil therapeutic use, Treatment Outcome, Alopecia drug therapy, Finasteride therapeutic use
- Published
- 2022
- Full Text
- View/download PDF
7. Nail clippings microscopy in alopecia areata: An unexplored tool.
- Author
-
Fernández LT, Gómez-Flores M, Herz-Ruelas ME, Garza-Rodríguez V, Franco-Márquez R, Sánchez-Muñoz MG, Ocampo-Candiani J, and Alba-Rojas EL
- Subjects
- Humans, Microscopy, Alopecia Areata
- Published
- 2022
- Full Text
- View/download PDF
8. Oral tranexamic acid with a triple combination cream versus oral tranexamic acid monotherapy in the treatment of severe melasma.
- Author
-
Martinez-Rico JC, Chavez-Alvarez S, Herz-Ruelas ME, Sosa-Colunga SA, Ocampo-Candiani J, Suro-Santos Y, and Vazquez Martinez O
- Subjects
- Combined Modality Therapy, Emollients therapeutic use, Female, Humans, Melanins, Treatment Outcome, Melanosis drug therapy, Tranexamic Acid
- Abstract
Background: Melasma is an acquired pigmentation disorder with a complex multifactorial etiopathogenesis. Oral tranexamic acid (TA) is a promising drug for its treatment and may enhance outcomes when used in combination., Objective: To provide evidence of the efficacy and safety of oral TA as a monotherapy, and in combination with a triple combination cream, for treating melasma in the Hispanic population., Methods: Forty-four female Hispanic patients with melasma were randomly assigned to receive 325 mg of oral TA every 12 h plus f-TCC (fluocinolone-based triple combination cream) every 24 h (group A) or 325 mg of oral TA every 12 h (group B) for 8 weeks, after which both groups were crossed-over, and treated for an additional 8 weeks. Evaluations of the mMASI score, the melanin index, and the MelasQoL were made at baseline and Weeks 4, 8, 12, and 16., Results: There was a 50.04% and 65.45% improvement in mMASI at Weeks 4 and 8, respectively, in group A, compared to baseline, while for Week 16, an improvement of 76.85% was achieved in group B compared to baseline. Highest scores were consistent with the use of the combined treatment modality in both groups, and were evidenced by the values of the melanin index obtained. There was no significant difference in MelasQoL scores between the 2 groups. No serious side effects were observed., Conclusion: The combination of oral TA and f-TCC is more effective than oral TA alone in the treatment of severe melasma in Hispanic patients., (© 2022 Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
- View/download PDF
9. Mycophenolate mofetil and mycophenolic acid for the treatment of eosinophilic fasciitis: report of two cases and literature review.
- Author
-
Moreno-Arquieta IA, Cardenas-de la Garza JA, Esquivel-Valerio JA, Riega-Torres J, Cuellar-Barboza A, Herz-Ruelas ME, Ocampo-Candiani J, and Galarza-Delgado DA
- Subjects
- Glucocorticoids therapeutic use, Humans, Immunosuppressive Agents adverse effects, Mycophenolic Acid adverse effects, Mycophenolic Acid therapeutic use, Autoimmune Diseases drug therapy, Fasciitis chemically induced, Fasciitis drug therapy
- Abstract
Eosinophilic fasciitis (EF) is an uncommon autoimmune connective tissue disorder characterized by edema, erythema, and subsequent induration of the extremities. It is commonly treated with corticosteroids but there is no treatment ladder for immunosuppressants or steroid-sparing agents. We report two EF cases treated effectively with mycophenolate mofetil (MMF) or mycophenolic acid (MPA) and present a literature review. We performed a MEDLINE search using the keywords 'eosinophilic fasciitis', 'Shulman syndrome', 'mycophenolic acid', or 'mofetil mycophenolate', and found 8 articles with 27 cases in which MMF or MPA was used. Twenty-nine cases were reviewed (2 reported herein and 27 from the literature search); all patients received a combination of systemic corticosteroids and MMF. MMF/MPA were given as a steroid-sparing agent in 27 (93.1%), in 1 (3.4%) as adjunctive therapy with other immunosuppressants, and in one, as monotherapy 1 (3.4%). Nineteen had a complete response, 6, a partial response, and 2 were unresponsive to diverse immunomodulators; in 2 cases, the outcome was not reported. MMF and MPA show promising therapeutic results and could be a treatment option to reduce corticosteroid related side effects.
- Published
- 2022
- Full Text
- View/download PDF
10. Systemic sclerosis in Hispanics: cutaneous salt and pepper lesions.
- Author
-
Ocampo-Candiani J, Suro-Santos Y, Villarreal-Martinez A, Herz-Ruelas ME, Galarza-Delgado DA, Hernandez-Galarza IJ, Villareal-Alarcon MA, Flores-Alvarado DE, Gomez-Flores M, Vazquez-Martinez OT, and Chavez-Alvarez S
- Subjects
- Hispanic or Latino, Humans, Scleroderma, Systemic
- Published
- 2022
- Full Text
- View/download PDF
11. Two new cases of testicular choriocarcinoma with cutaneous metastases.
- Author
-
Orizaga-Y-Quiroga TL, Ocampo-Garza SS, Olvera-Rodríguez V, Herz-Ruelas ME, Gómez-Flores M, and Ocampo-Candiani J
- Subjects
- Humans, Male, Choriocarcinoma, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms
- Published
- 2022
- Full Text
- View/download PDF
12. Association of frontal fibrosing alopecia and contact allergens in everyday skincare products in Hispanic females: a case-control study.
- Author
-
Ocampo-Garza SS, Herz-Ruelas ME, Chavez-Alvarez S, de la Fuente-Rodriguez DM, and Ocampo-Candiani J
- Subjects
- Alopecia, Case-Control Studies, Female, Fibrosis, Hispanic or Latino, Humans, Allergens, Lichen Planus
- Published
- 2021
- Full Text
- View/download PDF
13. Non-uremic Calciphylaxis and Parathyroid Adenoma, An Uncommon Association Requiring Early Recognition.
- Author
-
García-Lozano JA, Reyna-Rodríguez IL, Sánchez-Meza E, Gómez-García LA, Zapata-Salazar NA, Vázquez-Martínez O, and Herz-Ruelas ME
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2021
- Full Text
- View/download PDF
14. Suntan sign as a clinical diagnostic key in dermatomyositis.
- Author
-
Martinez-Rico JC, Rodriguez-Tamez G, Herz-Ruelas ME, Cardenas-de la Garza JA, Hernandes-Galarza IJ, Ocampo-Candiani J, and Chavez-Alvarez S
- Subjects
- Adult, Dermatomyositis diagnosis, Female, Humans, Suntan, Dermatomyositis pathology, Face pathology, Skin pathology
- Published
- 2021
- Full Text
- View/download PDF
15. Netherton Syndrome: Case Report and Review of the Literature.
- Author
-
Herz-Ruelas ME, Chavez-Alvarez S, Garza-Chapa JI, Ocampo-Candiani J, Cab-Morales VA, and Kubelis-López DE
- Abstract
Netherton syndrome (NS) is a rare genodermatosis with an autosomal recessive pattern of inheritance caused by pathogenic variants in the SPINK5 gene. It is characterized by a triad consisting of atopic diathesis, ichthyosis linearis circumflexa, and hair shaft abnormalities. Ichthyosis linearis circumflexa can be confused with atopic dermatitis leading to a delayed diagnosis. Furthermore, difficulty in making the differential diagnosis with other atopiform, erythrodermic, and ichthyosiform entities that exhibit hair shaft abnormalities represent a challenge. Trichoscopy is an accessible and noninvasive auxiliary diagnostic tool in these cases; the hair shaft abnormalities found in NS are bamboo, golf tee, and matchstick hairs. Identification of a pathogenic variant in the SPINK5 gene through genetic testing is necessary to confirm the diagnosis. Multiple treatment options are available including topical therapy with emollients, corticosteroids, calcineurin inhibitors, antiseptics, and narrowband UVB phototherapy. Systemic treatments comprehend intravenous immunoglobulins, and advances in the understanding of the pathophysiology of NS have led to more directed therapies with biologics such as infliximab, ixekizumab, secukinumab, ustekinumab, and dupilumab. Treatments currently under investigation include inhibitors of kallikrein 5, cathelicidins, drugs activating the transcription factor nuclear factor erythroid-derived 2-like 2, and gene therapy using autologous keratinocytes induced with a lentiviral vector encoding SPINK5., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2021 by S. Karger AG, Basel.)
- Published
- 2021
- Full Text
- View/download PDF
16. Indurated Plaques on the Legs: Think Lymphoma.
- Author
-
Watts-Santos A, Cuellar-Barboza A, Ramos-Cavazos CJ, Villarreal-Martinez A, Ocampo-Candiani J, and Herz-Ruelas ME
- Subjects
- Aged, Female, Herpesvirus 4, Human, Humans, Leg, Epstein-Barr Virus Infections, Lymphoma, Large B-Cell, Diffuse diagnosis, Lymphoma, Large B-Cell, Diffuse therapy, Skin Neoplasms diagnosis
- Abstract
Dear Editor, Primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT) is a rare and aggressive neoplasm. A timely diagnosis may prevent fatal outcomes; physicians should take this entity into consideration when assessing non-specific lesions on the lower limbs. We present a 69-year-old woman with a 1-month history of a firm plaque on her left leg. Physical examination revealed an asymptomatic, indurated, smooth, and erythematous plaque on the pretibial region of her left extremity (Figure 1, a). The rest of the physical examination was normal. Histological examination revealed cohesive sheets of a dense cell infiltrate in the dermis, composed of large round immunoblast-type cells with prominent nucleoli, and the presence of mitoses. Immunohistochemical stains were positive for CD20, Bcl2, and MUM1 (Figure 1, b-d). Additionally, c-MYC and Ki67 exhibited a 20% positivity; CD3 and CD10 were negative. The diagnosis of PCDLBCL-LT was established. Imaging and blood workup ruled out systemic involvement. Treatment with R-CHOP chemotherapy was initiated, with complete tumor regression by the third cycle. The patient completed 6 cycles and has remained disease-free after 18 months. Primary cutaneous B-cell lymphomas (CBCL) are lymphoproliferative disorders that appear on the skin without evidence of extracutaneous manifestations at the time of diagnosis (1). They represent 25 to 35% of all primary cutaneous lymphomas (2). In 2018, an updated version of the 2008 WHO-EORTC classification divided CBCLs into 5 subtypes: PCDLBCL-LT, primary cutaneous marginal zone B-cell lymphoma (PCMZL), primary cutaneous follicle center lymphoma (PCFCL), Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU), and intravascular large B-cell lymphoma (3). PCDLBCL-LT is the least common subtype, representing approximately 10% of all CBCLs and only 4% of all cutaneous lymphomas (2,3). Although the pathogenesis for most CBCLs is still unknown, positive serology for Lyme disease in a significant number of patients has been recognized as a probable etiologic association (4). PCDLBCL-LT is more frequent in women, and the mean age of presentation is 76 years. It usually presents as erythematous or bluish nodules, and up to 75% of the cases appears on one or both legs (1). Although infrequent, other locations have been reported, including the head, neck, trunk, and upper extremities (5). Workup should include a complete physical exam, skin biopsy, blood tests, and imaging (2,3). Histopathology shows a diffuse infiltrate in the dermis composed of large B-cells (centroblasts and/or immunoblasts) with extension to subcutaneous cellular tissue. These cells have round nuclei that are more than twice the size of normal lymphocytes, with prominent nucleoli. The immunophenotype of PCDLBCL-LT is CD20+, CD79a+, CD10-, and Bcl-6+/-, and strongly expresses Bcl-2, MUM1/IRF4, and FOX-P1 (1-3). Unlike the other indolent subtypes, PCDLBCL-LT is generally more aggressive with a poor prognosis. The 5-year disease survival rate is of approximately 50% (5). Management depends on the body surface area, location, and the patient's age and general health. To date, chemotherapy with R-CHOP remains the first line of therapy for PCDLBCL-LT, resulting in complete remission in up to 92% of cases (2). The prognostic characteristics of most PCDLBCL-LTs require timely and appropriate diagnosis and treatment.
- Published
- 2021
17. A kitchen utensil as a useful tool for ex vivo trichoscopy.
- Author
-
Orizaga-Y-Quiroga TL, Ocampo-Garza SS, Chavez-Alvarez S, Herz-Ruelas ME, and Ocampo-Candiani J
- Subjects
- Humans, Dermoscopy instrumentation, Hair diagnostic imaging, Hair Diseases diagnosis
- Published
- 2021
- Full Text
- View/download PDF
18. Frontal Fibrosing Alopecia: Is There a Link in Relatives?
- Author
-
Ocampo-Garza SS, Orizaga-Y-Quiroga TL, Olvera-Rodríguez V, Herz-Ruelas ME, Chavez-Alvarez S, Vañó-Galván S, and Ocampo-Candiani J
- Abstract
Frontal fibrosing alopecia (FFA) is an acquired primary lymphocytic cicatricial alopecia characterized by frontotemporal hairline recession, leading to scarring alopecia with a band-like distribution. Prevalence is increasing worldwide, being the most frequent cause of primary scarring alopecia. The natural history of this condition is variable; however, slow progression with spontaneous remission is the most frequent reported outcome. The etiopathogenesis of FFA remains to be elucidated; numerous hypotheses concerning hormonal effects, environmental factors, and genetic predisposition have been proposed. Special interest on genetic basis has emerged since the first familial case was reported. Only a few more familial cases have been published. We report 6 additional cases of female patients with familial FFA (F-FFA) from 3 different families. Sixty-six percent had a family history of autoimmune disease in first-degree relatives; these same patients had a personal history of autoimmune disease. The families described in this cohort study plus the personal and family history of autoimmune disease, as well as the recently described involved genomic loci; reinforced the hypothesis of this disease being genetic. It is important to consider studying this entity since there are scarce data regarding familial cases and this might give us a better insight toward understanding its pathogenesis., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2021 by S. Karger AG, Basel.)
- Published
- 2021
- Full Text
- View/download PDF
19. UVBNB phototherapy, a valuable tool for treating acquired perforating collagenosis: Case report and review of published cases.
- Author
-
Ramos-Cavazos CJ, Gómez-Flores M, Suárez-Sánchez KP, Ocampo-Candiani J, and Herz-Ruelas ME
- Subjects
- Administration, Oral, Administration, Topical, Adrenal Cortex Hormones administration & dosage, Aged, Biopsy, Camphor, Diagnosis, Differential, Female, Histamine Antagonists administration & dosage, Humans, Menthol, Ointments, Collagen Diseases diagnosis, Collagen Diseases radiotherapy, Ultraviolet Therapy methods
- Published
- 2021
- Full Text
- View/download PDF
20. The sunburn sign and the suntan sign- two novel findings in Hispanic patients with dermatomyositis.
- Author
-
Chavez-Alvarez S, Suro-Santos Y, Villarreal-Martinez A, Herz-Ruelas ME, Galarza-Delgado DA, Hernandez-Galarza IJ, Gomez-Flores M, Vazquez-Martinez OT, and Ocampo-Candiani J
- Subjects
- Hispanic or Latino, Humans, Skin, Suntan, Dermatomyositis diagnosis, Sunburn
- Published
- 2021
- Full Text
- View/download PDF
21. Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review.
- Author
-
Herz-Ruelas ME, Álvarez-Villalobos NA, Millán-Alanís JM, de León-Gutiérrez H, Ocampo-Garza SS, Gómez-Flores M, and Grimalt R
- Abstract
Androgenetic alopecia is the most common cause of hair loss [ Br J Dermatol . 2011 Jan;164(1):5-15]. Finasteride and minoxidil are the only approved treatments [ J Am Acad Dermatol . 2008 Oct;59(4):547-8 and J Eur Acad Dermatology Venereol . 2018 Jan;32(1):11-22]. Dutasteride is more potent than finasteride due to its ability to inhibit both 5-α-reductase type I and II [ Our Dermatol Online . 2017 Sep;9(1):75-9] though its adverse effects and long half-life contribute to the reluctance on its oral use. Mesotherapy could be a feasible alternative to avoid systemic exposure and side effects [ J Pan-Arab League Dermatologist . 2009 Feb;20(1):137-45]. We aim to perform a systematic review to analyze scientific literature with the purpose of comparing efficacy and adverse effects of both administration routes. Five clinical trials using oral route and 3 intralesional in comparison with placebo met criteria for inclusion. Regarding intralesional dutasteride, only one study [ Clin Dermatol . 2001 Mar;19(2):149-54] reported the mean change in hair count. Although both interventions favor over placebo, there are not enough data to reliably compare outcomes obtained between both routes. Mean increase in hair count observed with oral dutasteride was higher (MD: 15.92 hairs [95% CI: 9.87-21.96]; p = <0.00001; I
2 = 90%) compared to intralesional dutasteride in Abdallah's study (MD: 7.90 hairs [95% CI: 7.14-8.66]; p = <0.00001). Future studies are required to assess the therapeutic efficacy of both treatment routes, including head-to-head treatments before well-supported conclusions can be established., Competing Interests: There are no conflicts of interest., (Copyright © 2020 by S. Karger AG, Basel.)- Published
- 2020
- Full Text
- View/download PDF
22. Cutaneous manifestations of Castleman disease.
- Author
-
Chavez-Alvarez S, Villarreal-Martinez A, Ocampo-Candiani J, Gomez-Flores M, Vazquez-Martinez O, Gonzalez-Saldivar G, and Herz-Ruelas ME
- Subjects
- Adolescent, Adult, Humans, Castleman Disease complications, Castleman Disease diagnosis, Lymphatic Diseases, Lymphoproliferative Disorders, Paraneoplastic Syndromes diagnosis, Paraneoplastic Syndromes etiology, Pemphigus diagnosis, Pemphigus etiology
- Abstract
Background: Castleman disease (CD) is a lymphoproliferative B-cell disease that is diagnosed from lymphoid hyperplasia with vascular proliferation. Symptoms may include fever, night sweats, and weight loss. Cutaneous manifestations often may go unnoticed since little has been described in the literature regarding them., Materials and Methods: A search of CD with cutaneous manifestations was performed in PUBMED, ProQuest, Ovid, Scopus, EMBASE, and Medline. All articles included patients over 18 years of age with a diagnosis of CD and cutaneous manifestations., Results: A total of 68 articles were included. The most common cutaneous manifestations include paraneoplastic pemphigus and erythematous-brown plaques, papules, or nodules. Patients presenting with these manifestations should always have a thorough physical exam, and clinicians should try to identify any palpable lymph nodes. A complete workup to rule out other neoplasias needs to be performed as well., Conclusions: A better understanding of these skin manifestations of CD may help physicians promptly diagnose and reconsider the path of diagnostic tests to identify this entity., (© 2020 the International Society of Dermatology.)
- Published
- 2020
- Full Text
- View/download PDF
23. Association of Trichorhinophalangeal Syndrome and Loose Anagen Syndrome: A Case Report.
- Author
-
García-García SC, Herz-Ruelas ME, Gomez-Flores M, Vázquez-Herrera NE, Misciali C, Tosti A, Chavez-Alvarez S, Ocampo-Candiani J, and Villarreal-Martinez A
- Abstract
Trichorhinophalangeal syndrome (TRPS) is an autosomal dominant disease characterized by trichologic, craniofacial, and musculoskeletal abnormalities. Predominant clinical features include a pear-shaped nose with bulbous tip, long philtrum, protruding ears, and sparse hair on both the scalp and the lateral third of the eyebrows. Cone-shaped epiphyses are a common radiographic finding. Loose anagen syndrome (LAS) is a sporadic or autosomal dominant condition due to abnormalities in the hair's anchoring mechanism. It mostly affects children, who usually have reduced hair length, as well as hair that is easily plucked without pain. Recent contributions regarding trichoscopic findings of LAS have been made, describing rectangular black granular structures as a typical feature. An association between TRPS and LAS has been mentioned by hair experts, but no reports documenting this have been published. This case demonstrates the co-existence of both conditions in a patient with characteristic phenotypic traits of TRPS and LAS., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2020 by S. Karger AG, Basel.)
- Published
- 2020
- Full Text
- View/download PDF
24. Local secretion of stress hormones increases in alopecia areata lesions after treatment with UVA-1 phototherapy.
- Author
-
Cuellar-Barboza A, Cardenas-de la Garza JA, Cruz-Gómez LG, Barboza-Quintana O, Flores-Gutiérrez JP, Gómez-Flores M, Welsh O, Ocampo-Candiani J, and Herz-Ruelas ME
- Subjects
- Adrenocorticotropic Hormone metabolism, Adult, Alopecia Areata metabolism, Biopsy, Corticotropin-Releasing Hormone metabolism, Hair Follicle metabolism, Humans, Hypothalamo-Hypophyseal System pathology, Immunohistochemistry, Middle Aged, Pituitary-Adrenal System metabolism, Receptor, Melanocortin, Type 2 metabolism, Retrospective Studies, Signal Transduction, Skin metabolism, Alopecia Areata radiotherapy, Hormones metabolism, Phototherapy methods, Scalp metabolism, Ultraviolet Rays, alpha-MSH metabolism
- Abstract
Alopecia areata (AA) is an autoimmune disease of the hair follicle. Keratinocytes of the hair follicle generate an immunosuppressive environment by the local secretion of hormones of the hypothalamic-pituitary-adrenal axis of the skin (skin HPA analog). Our objective was to measure the local production of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and α-melanocyte-stimulating hormone (α-MSH) in the scalp tissue of patients with AA before and after ultraviolet A1 (UVA-1) phototherapy to determine their role in the pathogenesis of AA and the effect of UVA-1 on the AA hormonal environment. This was a retrospective and descriptive study of skin samples from 22 patients with AA before and after UVA-1 treatment. We compared the changes in the local hormonal environment by measuring CRH, ACTH, type 2 melanocortin receptor (ACTH receptor) and α-MSH with immunohistochemical stains. The positivity of MSH was significantly higher (P = .037) in the post-treatment samples compared with the baseline value. ACTH was significantly higher in intensity (P = .032) in the post-treatment samples compared with the initial value. CRH was significantly higher in intensity (P = .013) in baseline samples compared with the final biopsies. The positivity of the ACTH receptor MC2R was not different between the two groups (P = .626). In AA, an interruption in the signalling of CRH could decrease the local concentration of ACTH and MSH, and consequently, the immunosuppressive effect of these hormones. This phenomenon is normalized in the skin treated with UVA-1. A defective signalling system in the cutaneous HPA axis may be involved in the pathogenesis of AA., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2020
- Full Text
- View/download PDF
25. Immunotherapy for resistant and/or severe alopecia areata in a university hospital setting in Northern Mexico.
- Author
-
Herz-Ruelas ME, Lozano-Peña AK, Ocampo-Candiani J, Gómez-Flores M, Welsh-Lozano O, and Vázquez-Martínez O
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Hospitals, University, Humans, Male, Mexico, Middle Aged, Retrospective Studies, Young Adult, Adjuvants, Immunologic therapeutic use, Alopecia Areata therapy, Cyclobutanes therapeutic use, Cyclopropanes therapeutic use, Immunotherapy
- Published
- 2020
- Full Text
- View/download PDF
26. Lower than expected mortality with dexamethasone in toxic epidermal necrolysis: 30-year experience of a Northern Mexico reference hospital.
- Author
-
Gómez-Flores M, Villarreal-Villarreal CD, Welsh O, Cárdenas-de la Garza JA, Sánchez-Meza E, Áncer-Arellano J, Martinez-Moreno A, Ocampo-Candiani J, and Herz-Ruelas ME
- Published
- 2020
- Full Text
- View/download PDF
27. Acral bullous lichen sclerosus intolerant to UVA-1 successfully treated with narrowband ultraviolet B phototherapy.
- Author
-
Herz-Ruelas ME, Barboza-Quintana O, Cuéllar-Barboza A, Cárdenas-de la Garza JA, and Gómez-Flores M
- Subjects
- Female, Humans, Middle Aged, Lichen Sclerosus et Atrophicus pathology, Lichen Sclerosus et Atrophicus radiotherapy, Pain pathology, Pain radiotherapy, Quality of Life, Ultraviolet Rays adverse effects, Ultraviolet Therapy
- Abstract
Lichen sclerosus (LS) is an uncommon, chronic, lymphocyte-mediated, inflammatory dermatosis characterized by ivory-white patches with scar-like atrophy. Extragenital bullous lichen sclerosus may rarely affect palms and soles, causing severe pain and substantially impairing quality of life. We present the first case of acral bullous lichen sclerosus intolerant to UVA-1 phototherapy successfully treated with low doses of narrowband ultraviolet B phototherapy., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2019
- Full Text
- View/download PDF
28. IgG/IgA pemphigus: Report of a rare subtype of pemphigus.
- Author
-
Rodriguez-Vivian C, González-Benavides N, Herz-Ruelas ME, and Ocampo-Candiani J
- Subjects
- Aged, Dapsone therapeutic use, Female, Humans, Pemphigus drug therapy, Immunoglobulin A metabolism, Immunoglobulin G metabolism, Pemphigus metabolism
- Published
- 2019
- Full Text
- View/download PDF
29. A Practical Approach to the Diagnosis and Treatment of Adult Erythroderma.
- Author
-
Cuellar-Barboza A, Ocampo-Candiani J, and Herz-Ruelas ME
- Subjects
- Adult, Decision Trees, Humans, Dermatitis, Exfoliative diagnosis, Dermatitis, Exfoliative therapy
- Abstract
Erythroderma is an inflammatory skin syndrome that involves desquamation and erythema of more than 90% of the body surface area. It represents a final clinical endpoint for many adult dermatological conditions. The most frequent cause of erythroderma is psoriasis followed by eczematous conditions, drug-induced reactions, pityriasis rubra pilaris and cutaneous T-cell lymphomas. Diagnostic approach must include a thorough history and clinical examination. If the etiology of erythroderma is uncertain multiple skin biopsies may enhance diagnostic accuracy. The initial management of erythroderma must include a nutrition expert evaluation, fluid imbalance assessment, maintaining skin barrier function, sedative antihistamines and exclusion of secondary bacterial infection. We present a practical review of the etiology, diagnosis, and treatment of this entity., (Copyright © 2018 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
30. Efficacy of phototherapy in pityriasis lichenoides chronica of dark skin: A retrospective study from a tertiary center in Mexico.
- Author
-
Cuellar-Barboza A, Cardenas-De La Garza JA, Villarreal-Villarreal CD, Ocampo-Candiani J, Welsh O, Herz-Ruelas ME, and Gómez-Flores M
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Male, Mexico, Middle Aged, Pityriasis Lichenoides diagnosis, Pityriasis Lichenoides physiopathology, Remission Induction, Retrospective Studies, Skin pathology, Skin physiopathology, Treatment Outcome, Young Adult, Pityriasis Lichenoides radiotherapy, Skin radiation effects, Skin Pigmentation, Tertiary Care Centers, Ultraviolet Therapy
- Published
- 2018
- Full Text
- View/download PDF
31. A Case of Bullous Morphea Resistant to Methotrexate and Phototherapy Successfully Treated With Mycophenolate Mofetil.
- Author
-
Cuellar-Barboza A, Alberto Cardenas-De La Garza J, Daniel Villarreal-Villarreal C, Ocampo-Candiani J, Gomez-Flores M, Welsh O, and Herz-Ruelas ME
- Subjects
- Dermatologic Agents administration & dosage, Female, Humans, Methotrexate therapeutic use, Middle Aged, Mycophenolic Acid administration & dosage, Phytotherapy, Quality of Life, Scleroderma, Localized pathology, Scleroderma, Localized psychology, Treatment Outcome, Dermatologic Agents therapeutic use, Mycophenolic Acid therapeutic use, Scleroderma, Localized drug therapy
- Abstract
Bullous morphea is rare clinical variant of localized scleroderma characterized by the formation of bullae on sclerotic morphea plaques. Severe disease may be highly disabling and greatly impair quality of life. Current treatment strategies are based on anecdotal reports of clinical experience and include topical corticosteroids, methotrexate and phototherapy. Herein, we describe the case of a 56-year-old woman with progressive bullous sclerotic lesions who was successfully treated with mycophenolate mofetil after treatment failure with psoralen plus ultraviolet A therapy, ultraviolet A1 phototherapy, and methotrexate. Treatment with mycophenolate mofetil halted disease progression after 8 weeks. No major adverse effects were recorded in a 3-year follow-up with continuous treatment. This case suggests mycophenolate mofetil may be considered as an alternative for the treatment of resistant bullous morphea lesions. J Drugs Dermatol. 2018;17(10):1123-1125.
- Published
- 2018
32. Lichen planus pigmentosus and its variants: review and update.
- Author
-
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, and Ocampo Candiani J
- Subjects
- Adult, Age Factors, Aged, Biopsy, Needle, Female, Humans, Hyperpigmentation diagnosis, Immunohistochemistry, Incidence, Lichen Planus diagnosis, Male, Middle Aged, Prognosis, Risk Assessment, Severity of Illness Index, Sex Factors, Dermoscopy methods, Hyperpigmentation epidemiology, Hyperpigmentation pathology, Lichen Planus epidemiology, Lichen Planus pathology
- Abstract
Lichen planus pigmentosus (LPP) is considered a rare variant of lichen planus (LP). It is characterized by acquired dark brown to gray macular pigmentation located on sun-exposed areas of the face, neck, and flexures, commonly found in dark-skinned patients. In patients with LPP, an inflammatory lichenoid response results in marked pigmentary incontinence. It has been associated with hepatitis C virus, sun exposure, and contactants such as mustard oil and nickel. LPP-inversus affects fair and dark skin, predominantly involving flexural and intertriginous areas, while sun-exposed areas are spared; friction is an associated trigger. LPP along Blaschko's lines has been associated with susceptibility to genetic mosaicisms. LPP can present concomitantly with other variants of LP such as frontal fibrosing alopecia, as well as endocrinopathies, and autoimmune diseases. Treatment is difficult and consists of avoidance of triggers and topical and systemic medications in order to stop the inflammatory reaction and reduce pigmentation, improving aesthetic appearance and quality of life., (© 2017 The International Society of Dermatology.)
- Published
- 2018
- Full Text
- View/download PDF
33. Hair That Is Difficult to Manage in a Hispanic Girl.
- Author
-
Villarreal-Rodríguez A, Chávez-Alvarez S, Miranda-Maldonado I, and Herz-Ruelas ME
- Published
- 2018
- Full Text
- View/download PDF
34. Escalating dosimetry of UVA-1 in the treatment of alopecia areata.
- Author
-
Herz-Ruelas ME, Gomez-Flores M, Miranda-Maldonado I, Welsh E, Ocampo-Candiani J, and Welsh O
- Subjects
- Adult, Alopecia Areata drug therapy, Alopecia Areata pathology, Female, Hair growth & development, Hair Follicle radiation effects, Humans, Male, Middle Aged, Prospective Studies, Radiotherapy Dosage, Retreatment, Scalp pathology, Severity of Illness Index, Ultraviolet Therapy adverse effects, Alopecia Areata radiotherapy, Hair Follicle pathology, Ultraviolet Therapy methods
- Abstract
Background: Phototherapy can be an option in unresponsive alopecia areata (AA); however, variable results have been reported with its use. We could not find literature of treatment with UVA-1 in AA. A study was designed to evaluate progressive dosimetry to determine the initial dose and its increments., Methods: Patients with unresponsive AA were recruited. Twenty-five sessions of 30 J/cm
2 were administered. If hair regrowth was <75%, the dose was escalated to 60 J/cm2 . If hair improvement remained <75%, an additional 25 sessions at 120 J/cm2 were indicated. If total hair regrowth occurred before 75 sessions, a final visit was performed for biopsies and severity of alopecia tool (SALT) evaluation. Clinical and histopathological assessments were performed blindly. Adverse effects were recorded., Results: Nine men and 13 women were included; 16 were initially S1 , one S3 , and five S4 . Median age was 32 years and median evolution 10 months. Nine patients achieved an S0 , eight S1 , and five S4 (P = 0.005). The most notable improvement was with 60 J/cm2 (P = 0.02). Biopsies exhibited an absence of inflammation in five patients and mild persistence in 17. An increase of 43.75% in anagen hairs (P ≤ 0.001) was achieved, telogen hairs decreased 16.3% (P = 0.06), and catagen hairs were reduced 22.7% (P = 0.005). Pearson's correlation was -0.82 and P ≤ 0.001, when correlating anagen hairs with final SALT. Improvement has continued for 6 months post treatment. Mild xerosis was observed in all patients, and six (28.6%) developed transient mild hyperpigmentation., Conclusions: This study provides a basis for UVA-1 dosimetry evaluating its therapeutic value in AA., (© 2017 The International Society of Dermatology.)- Published
- 2017
- Full Text
- View/download PDF
35. Recalcitrant Facial Eruption.
- Author
-
Herz-Ruelas ME, González-González G, Bodden-Mendoza BA, and Martínez-Cabriales SA
- Subjects
- Child, Preschool, Facial Dermatoses therapy, Female, Humans, Facial Dermatoses diagnosis, Facial Dermatoses microbiology, Tinea diagnosis, Tinea therapy
- Published
- 2017
- Full Text
- View/download PDF
36. Disseminated fusariosis with endophthalmitis after skin trauma in acute lymphoblastic leukaemia.
- Author
-
Ocampo-Garza J, Herz-Ruelas ME, Chavez-Alvarez S, Gómez-Flores M, Vera-Cabrera L, Welsh-Lozano O, Gallardo-Rocha A, Escalante-Fuentes WG, and Ocampo-Candiani J
- Subjects
- Antineoplastic Agents therapeutic use, Humans, Male, Middle Aged, Mitoxantrone therapeutic use, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Endophthalmitis complications, Fusariosis complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
- Published
- 2016
- Full Text
- View/download PDF
37. Acquired Hyperpigmentation and Cicatricial Alopecia.
- Author
-
Ocampo-Garza J, Herz-Ruelas ME, and Ocampo-Candiani J
- Subjects
- Aged, Alopecia complications, Alopecia drug therapy, Chloroquine administration & dosage, Chloroquine therapeutic use, Diagnosis, Differential, Female, Humans, Hyperpigmentation complications, Hyperpigmentation drug therapy, Lichen Planus complications, Lichen Planus drug therapy, Tacrolimus administration & dosage, Tacrolimus therapeutic use, Treatment Outcome, Alopecia diagnosis, Hyperpigmentation diagnosis, Lichen Planus diagnosis
- Published
- 2016
- Full Text
- View/download PDF
38. Ultraviolet A-1 phototherapy as an alternative for resistant alopecia areata.
- Author
-
Herz-Ruelas ME, Welsh O, Gomez-Flores M, Welsh E, Miranda-Maldonado I, and Ocampo-Candiani J
- Subjects
- Adult, Female, Hair Follicle radiation effects, Humans, Male, Middle Aged, Retreatment, Young Adult, Alopecia Areata pathology, Alopecia Areata radiotherapy, Hair Follicle pathology, Ultraviolet Therapy methods
- Published
- 2015
- Full Text
- View/download PDF
39. Angioimmunoblastic T-cell lymphoma: a diagnostic challenge.
- Author
-
Ocampo-Garza J, Herz-Ruelas ME, González-Lopez EE, Mendoza-Oviedo EE, Garza-Chapa JI, Ocampo-Garza SS, Vázquez-Herrera NE, Miranda-Maldonado I, and Ocampo-Candiani J
- Abstract
Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15-20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for Epstein-Barr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles.
- Published
- 2014
- Full Text
- View/download PDF
40. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
- Author
-
Toledo-Bahena ME, Bucko A, Ocampo-Candiani J, Herz-Ruelas ME, Jones TM, Jarratt MT, Pollak RA, and Zane LT
- Subjects
- Administration, Topical, Adolescent, Adult, Aged, Antifungal Agents adverse effects, Boron adverse effects, Boron Compounds adverse effects, Bridged Bicyclo Compounds, Heterocyclic adverse effects, Cohort Studies, Dose-Response Relationship, Drug, Double-Blind Method, Erythema chemically induced, Female, Foot Dermatoses diagnosis, Humans, Male, Middle Aged, Onychomycosis diagnosis, Treatment Outcome, Young Adult, Antifungal Agents administration & dosage, Boron administration & dosage, Boron Compounds administration & dosage, Bridged Bicyclo Compounds, Heterocyclic administration & dosage, Foot Dermatoses drug therapy, Onychomycosis drug therapy
- Abstract
Objective: To assess the potential efficacy, safety, and optimal dosing concentration of tavaborole, a novel, boron-based pharmaceutical agent with broad-spectrum antifungal activity, for the treatment of onychomycosis of the toenail due to dermatophytes., Methods: One double-blind, randomized, vehicle-controlled study (study 1) and two open-label studies (studies 2 and 3) examined the efficacy, safety, and optimal dosing concentration of tavaborole topical solution applied once daily or three times weekly for 180 days at concentrations of 1.0%, 2.5%, 5.0%, or 7.5%. Patient cohort 3 of study 2 received open-label tavaborole 5.0% once daily for 360 days. All three studies assessed day 180 treatment success, defined as complete or partial clinical evidence of clear nail growth plus negative fungal culture., Results: A total of 336 patients were included in the intent-to-treat (ITT) or modified ITT populations and efficacy analyses across the 3 studies. In study 1, treatment success rates at day 180 were higher with tavaborole 2.5%, 5.0%, and 7.5% vs vehicle (27%, 26%, and 32% vs 14%, respectively; slope P=0.030). In cohort 3 of study 2, 7% of patients achieved treatment success with tavaborole 5.0% at day 360. Negative culture rates at day 180 in study 1 were numerically higher for tavaborole 2.5%, 5.0%, and 7.5% vs vehicle (slope P=0.046). Application-site reactions of general irritation, erythema, scaling, and stinging/burning were most common with tavaborole 7.5%, were generally mild to moderate, and resolved with treatment discontinuation and/or a reduction in dosing frequency. No systemic safety concerns were observed., Conclusion: Tavaborole solution demonstrated favorable efficacy and safety in phase 2 clinical studies. Based on these findings, tavaborole topical solution, 5% was further investigated in larger, more definitive phase 3 studies. Results from these completed phase 3 studies will provide additional evidence regarding the safety and efficacy of tavaborole in the treatment of toenail onychomycosis.
- Published
- 2014
41. Crusted demodicosis in an immunocompetent pediatric patient.
- Author
-
Guerrero-González GA, Herz-Ruelas ME, Gómez-Flores M, and Ocampo-Candiani J
- Abstract
Demodicosis refers to the infestation by Demodex spp., a saprophytic mite of the pilosebaceous unit. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, papulopustular, and granulomatous rosacea, among others. We report the case of a 7-year-old female presenting with pruritic grayish crusted lesions over her nose and cheeks, along with facial erythema, papules, and pustules. The father referred chronic use of topical steroids. A potassium hydroxide mount of a pustule scraping revealed several D. folliculorum mites. Oral ivermectin (200 μg/kg, single dose) plus topical permethrin 5% lotion applied for 3 consecutive nights were administered. Oral ivermectin was repeated every week and oral erythromycin plus topical metronidazole cream was added. The facial lesions greatly improved within the following 3 months. While infestation of the pilosebaceous unit by Demodex folliculorum mites is common, only few individuals present symptoms. Demodicosis can present as pruritic papules, pustules, plaques, and granulomatous facial lesions. To our knowledge, this is the first reported case of facial crusted demodicosis in an immunocompetent child. The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids.
- Published
- 2014
- Full Text
- View/download PDF
42. Ulcerated radiodermatitis induced after fluoroscopically guided stent implantation angioplasty.
- Author
-
Herz-Ruelas ME, Gómez-Flores M, Moxica-Del Angel J, Miranda-Maldonado I, Gutiérrez-Villarreal IM, Guerrero-González GA, and Villarreal-Rodríguez AO
- Abstract
Cases of radiation-induced skin injury after fluoroscopically guided procedures have been reported since 1996, though the majority of them have been published in Radiology and Cardiology literature, less frequently in Dermatology journals. Chronic radiation dermatitis induced by fluoroscopy can be difficult to diagnose; a high grade of suspicion is required. We report a case of an obese 46-year-old man with hypertension, dyslipidemia, and severe coronary artery disease. He developed a pruritic and painful atrophic ulcerated skin plaque over his left scapula, six months after fluoroscopically guided stent implantation angioplasty. The diagnosis of radiodermatitis was confirmed histologically. We report this case to emphasize the importance of recognizing fluoroscopy as a cause of radiation dermatitis. A good clinical follow-up at regular intervals is important after long and complicated procedures, since the most prevalent factor for injury is long exposure time.
- Published
- 2014
- Full Text
- View/download PDF
43. Therapeutic evaluation of UVB-targeted phototherapy in vitiligo that affects less than 10% of the body surface area.
- Author
-
Welsh O, Herz-Ruelas ME, Gómez M, and Ocampo-Candiani J
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome, Ultraviolet Therapy, Vitiligo therapy
- Abstract
Background: Current treatments for vitiligo include different therapeutic modalities, such as corticosteroids, immunomodulators, pseudocatalase, skin grafts, diverse types of phototherapy [ultraviolet B (UVB), psoralen plus UVA (PUVA), narrow-band UVB (NB-UVB)], and, recently, targeted phototherapy. After a literature search, we found only two studies using different targeted broad-band UVB units for the treatment of vitiligo., Objective: To evaluate the repigmentation response induced with broad-band, UVB-targeted phototherapy used as monotherapy in patients with vitiligo affecting less than 10% of the skin surface., Methods: Twelve patients were recruited for treatment with 30 sessions of UVB-targeted phototherapy administered twice weekly. The assessment of repigmentation was made from a comparison of baseline photographs with those after 30 sessions by two independent investigators. Morphometric analysis was performed using a computer program., Results: Repigmentation with an average of 66.25% was obtained on lesions of the face, and of 31.5% on the neck, trunk, and genitalia. On the extremities, there was no repigmentation. Itching, a burning sensation, erythema, desquamation, and transitory hyperpigmentation were observed in some patients. Minimal blistering and ulceration were observed in one patient., Conclusion: Targeted UVB phototherapy seems to be effective for the repigmentation of vitiligo in lesions located on the face, to a lesser degree on the trunk, and with no response in acral lesions; there were minimal adverse effects that did not require discontinuation of treatment.
- Published
- 2009
- Full Text
- View/download PDF
44. Treatment of Fordyce spots with CO2 laser.
- Author
-
Ocampo-Candiani J, Villarreal-Rodríguez A, Quiñones-Fernández AG, Herz-Ruelas ME, and Ruíz-Esparza J
- Subjects
- Adult, Carbon Dioxide, Humans, Male, Laser Therapy, Lip, Sebaceous Glands radiation effects
- Abstract
Background: Fordyce spots are heterotopic sebaceous glands that can be located at the lips' vermilion or the oral mucosa. Although this is considered a rather common disorder, a treatment for this condition that sometimes affects patients from only a cosmetic viewpoint has not yet been described., Objective: To evaluate CO2 superpulsed laser treatment in two subjects with Fordyce spots., Methods: Two patients with papules and yellowish plaques at the upper lip corresponding to Fordyce spots were treated with coherent Ambulase CO2 superpulsed laser (Coherent Medical, Palo Alto, CA); after informed consent was obtained, two to three passes were performed in one session using 2 and 4 W and a spot size of 2 mm., Results: Complete re-epithelization was observed 2 weeks later with no residual Fordyce papules in the treated area and no side effects., Conclusion: Our findings suggest that CO2 superpulsed laser can be considered a safe and effective treatment for patients with Fordyce spots, offering excellent cosmetic results.
- Published
- 2003
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.