1. Complicated intra-abdominal infections in Europe: a comprehensive review of the CIAO study
- Author
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Sartelli Massimo, Catena Fausto, Ansaloni Luca, Leppaniemi Ari, Taviloglu Korhan, van Goor Harry, Viale Pierluigi, Lazzareschi Daniel, Coccolini Federico, Corbella Davide, de Werra Carlo, Marrelli Daniele, Colizza Sergio, Scibè Rodolfo, Alis Halil, Torer Nurkan, Navarro Salvador, Sakakushev Boris, Massalou Damien, Augustin Goran, Catani Marco, Kauhanen Saila, Pletinckx Pieter, Kenig Jakub, Di Saverio Salomone, Jovine Elio, Guercioni Gianluca, Skrovina Matej, Diaz-Nieto Rafael, Ferrero Alessandro, Rausei Stefano, Laine Samipetteri, Major Piotr, Angst Eliane, Pittet Olivier, Herych Ihor, Agresta Ferdinando, Vettoretto Nereo, Poiasina Elia, Tepp Jaan, Weiss Gunter, Vasquez Giorgio, Vladov Nikola, Tranà Cristian, Delibegovic Samir, Dziki Adam, Giraudo Giorgio, Pereira Jorge, Tzerbinis Helen, van Dellen David, Hutan Martin, Vereczkei Andras, Krasniqi Avdyl, Seretis Charalampos, Mesina Cristian, Rems Miran, Campanile Fabio, Coletta Pietro, Uotila-Nieminen Mirjami, Dente Mario, Bouliaris Konstantinos, Lasithiotakis Konstantinos, Khokha Vladimir, Zivanovic Dragoljub, Smirnov Dmitry, Marinis Athanasios, Negoi Ionut, Ney Ludwig, Bini Roberto, Leon Miguel, Aloia Sergio, Huchon Cyrille, Moldovanu Radu, de Melo Renato, Giakoustidis Dimitrios, Ioannidis Orestis, Cucchi Michele, Pintar Tadeja, Krivokapic Zoran, and Petrovic Jelena
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract The CIAO Study (“Complicated Intra-Abdominal infection Observational” Study) is a multicenter investigation performed in 68 medical institutions throughout Europe over the course of a 6-month observational period (January-June 2012). Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 2,152 patients with a mean age of 53.8 years (range: 4–98 years) were enrolled in the study. 46.3% of the patients were women and 53.7% were men. Intraperitoneal specimens were collected from 62.2% of the enrolled patients, and from these samples, a variety of microorganisms were collectively identified. The overall mortality rate was 7.5% (163/2.152). According to multivariate analysis of the compiled data, several criteria were found to be independent variables predictive of patient mortality, including patient age, the presence of an intestinal non-appendicular source of infection (colonic non-diverticular perforation, complicated diverticulitis, small bowel perforation), a delayed initial intervention (a delay exceeding 24 hours), sepsis and septic shock in the immediate post-operative period, and ICU admission. Given the sweeping geographical distribution of the participating medical centers, the CIAO Study gives an accurate description of the epidemiological, clinical, microbiological, and treatment profiles of complicated intra-abdominal infections (IAIs) throughout Europe.
- Published
- 2012
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