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7. A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen–UVA photochemical treatment

Author

Knutson, F., Osselaer, J., Pierelli, L., Lozano, M., Cid, J., Tardivel, R., Garraud, O., Hervig, T., Domanovic, D., Cukjati, M., Gudmundson, S., Hjalmarsdottir, I. B., Castrillo, A., Gonzalez, R., Brihante, D., Santos, M., Schlenke, P., Elliott, A., Lin, J.-S., Tappe, D., Stassinopoulos, A., Green, J., and Corash, L.

Published
2015
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14. Pathogen inactivation of platelet concentrates

Author

Reesink, H. W., Panzer, S., McQuilten, Z. K., Wood, E. M., Marks, D. C., Wendel, S., Trigo, F., Biagini, S., Olyntho, S., Devine, D. V., Mumford, I., Cazenave, J.-P., Rasonglès, P., Garraud, O., Richard, P., Schooneman, F., Vezon, G., Al Radwan, R., Brand, A., Hervig, T., Castro, E., Lozano, M., Navarro, L., Puig, L., Almazán, C., MacLennan, S., Cardigan, R., Franklin, I. M., and Prowse, C.

Published
2010
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15. Inventory Management

Author

Devine, D. V., Sher, G. D., Reesink, H. W., Panzer, S., Hetzel, P. A. S., Wong, J. K., Horvath, M., Leitner, G. C., Schennach, H., Nussbaumer, W., Genoe, K., Cioffi, J. M., Givisiez, F. N., Rogerson, M., Howe, D., Delage, G., Sarappa, C., Charbonneau, Y., Fu, Y., Šarlija, D., Vuk, T., Patko, Strauss M., Balija, M., Jukić, I., Ali, A., Auvinen, M.-K., Jaakonsalo, E., Cazenave, J.-P., Waller, C., Kientz, D., David, B., Walther-Wenke, G., Heiden, M., Lin, C. K., Tsoi, W. C., Lee, C. K., Barotine-Toth, K., Sawant, R. B., Murphy, W., Quirke, B., Bowler, P., Shinar, E., Yahalom, V., Aprili, G., Piccoli, P., Gandini, G., Tadokoro, K., Nadarajan, V. S., Kort, W. de, Jansen, N., Flanagan, P., Forsberg, P.-O., Hervig, T., Letowska, M., Lachert, E., Dudziak, K., Antoniewicz-Papis, J., Olim, G. de, Nascimento, F., Hindawi, S., Teo, D., Reddy, R., Scholtz, J., Swanevelder, R., Rovira, L. P., Sauleda, S., Carasa, M. A. V., Vaquero, M. P., Ania, M. A., Gulliksson, H., Holdsworth, S., Cotton, S., Howell, C., Baldwin, C., Cusick, R. M., Geele, G. A., Paden, C., McEvoy, P., Gottschall, J. L., McLaughlin, L. S., Benjamin, R. J., Eder, A., Draper, N. L., AuBuchon, J. P., and de González, León G.

Published
2010
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25. A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial

Author

Ypma, P.F., Meer, P.F. van der, Heddle, N.M., Hilten, J.A. van, Stijnen, T., Middelburg, R.A., Hervig, T., Bom, J.G. van der, Brand, A., Kerkhoffs, J.L.H., and PREPAReS Study Grp

Subjects
Adult, medicine.medical_specialty, Evidence-based practice, Adolescent, bleeding assessment, Ultraviolet Rays, Riboflavin, Hemorrhage, thrombocytopenia, Platelet Transfusion, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Randomized controlled trial, Clinical Protocols, law, Interim, Clinical endpoint, medicine, Blood-Borne Pathogens, Protocol, Humans, Single-Blind Method, Young adult, Adverse effect, Aged, Protocol (science), pathogen reduction, business.industry, General Medicine, Bacterial Infections, Middle Aged, bleeding, Surgery, Platelet transfusion, Treatment Outcome, Virus Diseases, Emergency medicine, business, 030215 immunology, Haematology (Incl Blood Transfusion)
Abstract

Introduction Patients with chemotherapy-induced thrombocytopaenia frequently experience minor and sometimes severe bleeding complications. Unrestrictive availability of safe and effective blood products is presumed by treating physicians as well as patients. Pathogen reduction technology potentially offers the opportunity to enhance safety by reducing bacterial and viral contamination of platelet products along with a potential reduction of alloimmunisation in patients receiving multiple platelet transfusions. Methods and analysis To test efficacy, a randomised, single-blinded, multicentre controlled trial was designed to evaluate clinical non-inferiority of pathogen-reduced platelet concentrates treated by the Mirasol system, compared with standard plasma-stored platelet concentrates using the percentage of patients with WHO grade ≥2 bleeding complications as the primary endpoint. The upper limit of the 95% CI of the non-inferiority margin was chosen to be a ≤12.5% increase in this percentage. Bleeding symptoms are actively monitored on a daily basis. The adjudication of the bleeding grade is performed by 3 adjudicators, blinded to the platelet product randomisation as well as by an automated computer algorithm. Interim analyses evaluating bleeding complications as well as serious adverse events are performed after each batch of 60 patients. The study started in 2010 and patients will be enrolled up to a maximum of 618 patients, depending on the results of consecutive interim analyses. A flexible stopping rule was designed allowing stopping for non-inferiority or futility. Besides analysing effects of pathogen reduction on clinical efficacy, the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) is designed to answer several other pending questions and translational issues related to bleeding and alloimmunisation, formulated as secondary and tertiary endpoints. Ethics and dissemination Ethics approval was obtained in all 3 participating countries. Results of the main trial and each of the secondary endpoints will be submitted for publication in a peer-reviewed journal. Trial registration number NTR2106; Pre-results.

Published
2016

28. Challenges and opportunities to prevent transfusion errors: a Qualitative Evaluation for Safer Transfusion (QUEST)

Author

Heddle, NM, Fung, M, Hervig, T, Szczepiorkowski, ZM, Torretta, L, Arnold, E, Lane, S, and Murphy, MF

Abstract

BACKGROUND: One of the most frequent causes of transfusion-associated morbidity or mortality is the transfusion of the wrong blood to the wrong patient. This problem persists in spite of the incorporation of numerous procedures into the pretransfusion checking process in an effort to improve patient safety. A qualitative study was undertaken to understand this process from the perspective of those who administer blood products and to identify concerns and suggestions to improve safety. STUDY DESIGN AND METHODS: Twelve focus group discussions and seven individual interviews were conducted at six hospitals in five countries (n = 72 individuals). Health care professionals from a variety of clinical areas participated. Data analysis identified common themes using the constant comparison method. RESULTS: Five major themes emerged from the analysis: the pretransfusion checking process, training, policy, error, and monitoring. Findings include the following: staff were aware and appreciative of the seriousness of errors and were receptive to continuous monitoring, the focus was on checking the bag label with the paperwork rather than the bag label with the patient at the bedside, training methods varied with most perceived to have minimal effectiveness, and access to policies was challenging and keeping up to date was difficult. Other factors that could contribute to errors included high volume of workload distractions and interruptions and familiarity or lack of familiarity with patients. CONCLUSIONS: Multiple factors can contribute to errors during the pretransfusion checking limiting the effectiveness of any individual intervention designed to improve safety. Areas of further research to improve safety of blood administration were identified.

Published
2016

29. Challenges and opportunities to prevent transfusion errors: a Qualitative Evaluation for Safer Transfusion (QUEST)

Author

Heddle, N, Fung, M, Hervig, T, Szczepiorkowski, Z, Torretta, L, Arnold, E, Lane, S, Murphy, M, and Collaborative, BEST

Abstract

BACKGROUND: One of the most frequent causes of transfusion-associated morbidity or mortality is the transfusion of the wrong blood to the wrong patient. This problem persists in spite of the incorporation of numerous procedures into the pretransfusion checking process in an effort to improve patient safety. A qualitative study was undertaken to understand this process from the perspective of those who administer blood products and to identify concerns and suggestions to improve safety. STUDY DESIGN AND METHODS: Twelve focus group discussions and seven individual interviews were conducted at six hospitals in five countries (n = 72 individuals). Health care professionals from a variety of clinical areas participated. Data analysis identified common themes using the constant comparison method. RESULTS: Five major themes emerged from the analysis: the pretransfusion checking process, training, policy, error, and monitoring. Findings include the following: staff were aware and appreciative of the seriousness of errors and were receptive to continuous monitoring, the focus was on checking the bag label with the paperwork rather than the bag label with the patient at the bedside, training methods varied with most perceived to have minimal effectiveness, and access to policies was challenging and keeping up to date was difficult. Other factors that could contribute to errors included high volume of workload distractions and interruptions and familiarity or lack of familiarity with patients. CONCLUSIONS: Multiple factors can contribute to errors during the pretransfusion checking limiting the effectiveness of any individual intervention designed to improve safety. Areas of further research to improve safety of blood administration were identified.

Published
2016

33. RBC alloantibody prevalence and specificity in a Western Norwegian tertiary hospital.

Author

Erikstein, B. S., Hagen, K. G., and Hervig, T.

Subjects
ERYTHROCYTES, PREGNANT women, BLOOD donors, BLOOD products, BLOOD transfusion
Abstract

SUMMARY Background and Objective: Although several studies focus on red blood cell (RBC) alloantibody distribution in selected patient populations, few address the specificity and frequency in all relevant groups. This study reports alloantibody frequency, distribution and the relationship to age and gender in blood donors, pregnant women and potential recipients of blood products. Methods: This historical cohort study included 55 462 consecutive antibody screening tests from a tertiary Western Norwegian Hospital. Descriptive statistics were performed, and the results were compared with the literature. Results: The detection and immunisation frequency for the whole cohort were 0·39 and 0·51%, respectively, whereas the RBC alloantibody prevalence was 0·73%. The most frequent RBC alloantibodies were anti‐E (20·1%), anti‐M (18·7%), anti‐K (9·8%), anti‐D (8·9%) and anti‐Fy(a) (7·0%). In pregnant women, the most frequent RBC alloantibodies were anti‐M, anti‐D and anti‐Le(a) (20·8, 18·9 and 18·9%, respectively), whereas there was no anti‐K detected. Anti‐E and anti‐M were the dominating RBC alloantibodies in the pre‐transfusion testing of in‐hospital patients (24·1 and 17·1%, respectively). Eighteen (9·2%) persons in the total cohort had two RBC alloantibodies, six persons had three alloantibodies, and two persons had four alloantibodies. Rh and K typing to prevent future immunisations was only performed in 21·0% of the individuals who presented with a new alloantibody; despite that, 50·5% of the detected alloantibodies had such specificities. Conclusions: The immunisation frequency and the level of anti‐K are low compared to national and international studies. Rh and K phenotype‐matched blood transfusions might be a feasible future strategy to further decrease RBC alloantibodies. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Intraoperative transfusion practices in Europe

Author

Meier, J., Filipescu, D., Kozek Langenecker, S., Llau Pitarch, J., Mallett, S., Martus, P., Matot, I., ETPOS collaborators: Accurso, G., Ahrens, N., Akan, M., Åkeröy, K., Aksoy, O., Alanoğlu, Z., Alfredo, M., Alkis, N., Almeida, V., Alousi, M., Alves, C., Amaral, J., Ambrosi, X., Ana, I., Anastase, D., Andersson, M., Andreou, A., Anthopoulos, G., Apanaviciute, D., Arbelaez, A., Arcade, A., Arion Balescu, C., Arun, O., Azenha, M., Bacalbasa, N., Baeten, W., Balandin, A., Barquero López, M., Barsan, V., Bascuas, B., Basora, M., Baumann, H., Bayer, A., Bell, A., Belmonte Cuenca, J., Bengisun, Z., Bento, C., Beran, M., Bermudez Lopez, M., Bernardino, A., Berthelsen, K., Bigat, Z., Bilshiene, D., Bilska, M., Bisbe Vives, E., Biscioni, T., Björn, H., Blom, T., Bogdan Prodan, A., Bogdanovic Dvorscak, M., Boisson, M., Bolten, J., Bona, F., Borg, F., Boros, C., Borys, M., Boveroux, P., Boztug Uz, N., Brettner, F., Brisard, L., Britta de, W., Browne, G., Budow, K., Buerkle, H., Buggy, D., Cain, A., Calancea, E., Calarasu, F., Calder, V., Camci, A., Campiglia, L., Campos, B., Camps, A., Carlos, D., Carreira, C., Carrilho, A., Carvalho, P., Cassinello, C., Cattan, A., Cenni, L., Cerny, V., Ceyda Meço, B., Chesov, I., Chishti, A., Chupin, A., Cikova, A., Cindea, I., Cintula, D., Ciobanasu, R., Clements, D., Cobiletchi, S., Coburn, M., Coghlan, L., Collyer, T., Copotoiu, S., Copotoiu, R., Corneci, D., CORTEGIANI, Andrea, Coskunfirat, O., Costea, D., Czuczwar, M., Davies, K., De Baerdemaeker, L., De Hert, S., Debernardi, F., Decagny, S., Deger Coskunfirat, N., Diana, T., Diana, G., Dias, S., Dickinson, M., Dobisova, A., Dragan, A., Droc, G., Duarte, S., Dunk, N., Ekelund, K., Ekmekçi, P., Elena, C., Ellimah, T., Espie, L., Everett, L., Ferguson, A., Fernandes, M., Fernández, J., Ferner, M., Ferreira, D., Ferrie, R., Flassikova, Z., Fleischer, A., Font, A., Galkova, K., Garcia, I., Garner, M., Gasenkampf, A., Gelmanas, A., Gherghina, V., Gilsanz, F., Giokas, G., Goebel, U., Gomes, P., Gonçalves Aguiar, J., Gonzalez Monzon, V., Gottschalk, A., Gouraud, J., Gramigni, E., Grintescu, I., Grynyuk, A., Grytsan, A., Guasch, E., Gustin, D., Hans, G., Harazim, H., Hervig, T., Hidalgo, F., Higham, C., Hirschauer, N., Hoeft, A., Innerhofer, P., Innerhofer Pompernigg, N., Jacobs, S., Jakobs, N., Jamaer, L., James, S., Jawad, M., Jesus, J., Jhanji, S., Jipa Lavina, N., Jokinen, J., Jovanovic, G., Jubera, M., Kahn, D., Karjagin, J., Kasnik, D., Katsanoulas, K., Kelle, H., Kelleher, M., Kessler, F., Kirigin, B., Kiskira, O., Kivik, P., Klimi, P., Klučka, J., Koers, L., Kontrimaviciut, E., Koopman van Gemert, A., Korfiotis, D., Kosinová, M., Koursoumi, E., Kranke, P., Kresic, M., Krobot, R., Kropman, L., Kulikov, A., Kvolik, S., Kvrgic, I., Kyttari, A., Lagarto, F., Lance, M., Laufenberg, R., Lauwick, S., Lecoq, J., Leech, L., Lidzborski, L., Liliana, H., Linda, F., Lopes, A., Lopez, L., Lopez Alvarez, A., Lorenzi, I., Lorre, G., Lucian, H., Lupis, T., Lupu, M., Macas, A., Macedo, A., Maggi, G., Mallor, T., Manoleli, A., Manolescu, R., Manrique, S., Maquoi, I., Marios Konstantinos, T., Markovic Bozic, J., Markus, W., Marques, M., Martinez, R., Martinez, E., Martínez, E., Martinho, H., Martins, D., Martires, E., Matias, F., Mauff, S., Meale, P., Merz, H., Meybohm, P., Militello, M., Mincu, N., Miranda, M., Mirea, L., Moghildea, V., Moise, A., Molano Diaz, P., Moltó, L., Monedero, P., Moral, V., Moreira, Z., Moret, E., Mulders, F., Munteanu, A., Nadia Diana, K., Nair, A., Neskovic, V., Ninane, V., Nitu, D., Oberhofer, D., Odeberg Wernerman, S., Oganjan, J., Omur, D., Orallo Moran, M., Ozkardesler, S., Pacasová, R., Paklar, N., Pandazi, A., Papaspyros, F., Paraskeuopoulos, T., Parente, S., Paunescu, M., Pavičić Šarić, J., Pereira, F., Pereira, E., Pereira, L., Perry, C., Petri, A., Petrovic, U., Pica, S., Pinheiro, F., Pinto, J., Pinto, F., Piwowarczyk, P., Platteau, S., Poeira, R., Popescu, R., Popica, G., Poredos, P., Prasser, C., Preckel, B., Prospiech, A., Pujol, R., Raimundo, A., RAINERI, Santi Maurizio, Rakic, D., Ramadan, M., Ramazanoğlu, A., Rantis, A., Raquel, F., Rätsep, I., Real, C., Reikvam, T., Reis, L., Rigal, J., Rohner, A., Rokk, A., Roman Fernandez, A., Rosenberger, P., Rossaint, R., Rozec, B., Rudolph, T., Saeed, Y., Safonov, S., Saka, E., Samama, C., Sánchez López, Ó., Sanchez Perez, D., Sanchez Sanchez, Y., Sandeep, V., Sandu, M., Sanlı, S., Saraiva, A., Scarlatescu, E., Schiraldi, R., Schittek, G., Schnitter, B., Schuster, M., Seco, C., Selvi, O., Senard, M., Serra, S., Serrano, H., Shmigelsky, A., Silva, L., Simeson, K., Singh, R., Sipylaite, J., Skitek, K., Skok, I., Smékalová, O., Smirnova, N., Sofia, M., Soler Pedrola, M., Söndergaard, S., Sõrmus, A., Sørvoll, I., Soumelidis, C., Spindler Yesel, A., Stefan, M., Stevanovic, A., Stevikova, J., Stivan, S., Štourač, P., Striteska, J., Strys, L., Suljevic, I., Tania, M., Tareco, G., Tena, B., Theodoraki, K., Tifrea, M., Tikuisis, R., Tolós, R., Tomasi, R., Tomescu, D., Tomkute, G., Tormos, P., Trepenaitis, D., Troyan, G., Unic Stojanovic, D., Unterrainer, A., Uranjek, J., Valsamidis, D., van Dasselaar, N., Van Limmen, J., van Noord, P., van Poorten, J., Vanderlaenen, M., Varela Garcia, O., Velasco, A., Veljovic, M., Vera Bella, J., Vercauteren, M., Verdouw, B., Verenkin, V., Veselovsky, T., Vieira, H., Villar, T., Visnja, I., Voje, M., von Dossow Hanfstingl, V., Von Langen, D., Vorotyntsev, S., Vujanovič, V., Vukovic, R., Watt, P., Werner, E., Wernerman, J., Wittmann, M., Wright, M., Wunder, C., Wyffels, P., Yakymenko, Y., Yıldırım, Ç., Yılmaz, H., Zacharowski, K., Záhorec, R., Zarif, M., Zielinska Skitek, E., Zsisku, L., Selçuk Üniversitesi, Meier, J., Filipescu, D., Kozek-Langenecker, S., Llau Pitarch, J., Mallett, S., Martus, P., Matot, I., ETPOS collaborators: Accurso, G., Ahrens, N., Akan, M., Åkeröy, K., Aksoy, O., Alanoğlu, Z., Alfredo, M., Alkis, N., Almeida, V., Alousi, M., Alves, C., Amaral, J., Ambrosi, X., Ana, I., Anastase, D., Andersson, M., Andreou, A., Anthopoulos, G., Apanaviciute, D., Arbelaez, A., Arcade, A., Arion-Balescu, C., Arun, O., Azenha, M., Bacalbasa, N., Baeten, W., Balandin, A., Barquero López, M., Barsan, V., Bascuas, B., Basora, M., Baumann, H., Bayer, A., Bell, A., Belmonte Cuenca, J., Bengisun, Z., Bento, C., Beran, M., Bermudez Lopez, M., Bernardino, A., Berthelsen, K., Bigat, Z., Bilshiene, D., Bilska, M., Bisbe Vives, E., Biscioni, T., Björn, H., Blom, T., Bogdan Prodan, A., Bogdanovic Dvorscak, M., Boisson, M., Bolten, J., Bona, F., Borg, F., Boros, C., Borys, M., Boveroux, P., Boztug Uz, N., Brettner, F., Brisard, L., Britta de, W., Browne, G., Budow, K., Buerkle, H., Buggy, D., Cain, A., Calancea, E., Calarasu, F., Calder, V., Camci, A., Campiglia, L., Campos, B., Camps, A., Carlos, D., Carreira, C., Carrilho, A., Carvalho, P., Cassinello, C., Cattan, A., Cenni, L., Cerny, V., Ceyda Meço, B., Chesov, I., Chishti, A., Chupin, A., Cikova, A., Cindea, I., Cintula, D., Ciobanasu, R., Clements, D., Cobiletchi, S., Coburn, M., Coghlan, L., Collyer, T., Copotoiu, S., Copotoiu, R., Corneci, D., Cortegiani, A., Coskunfirat, O., Costea, D., Czuczwar, M., Davies, K., De Baerdemaeker, L., De Hert, S., Debernardi, F., Decagny, S., Deger Coskunfirat, N., Diana, T., Diana, G., Dias, S., Dickinson, M., Dobisova, A., Dragan, A., Droc, G., Duarte, S., Dunk, N., Ekelund, K., Ekmekçi, P., Elena, C., Ellimah, T., Espie, L., Everett, L., Ferguson, A., Fernandes, M., Fernández, J., Ferner, M., Ferreira, D., Ferrie, R., Flassikova, Z., Fleischer, A., Font, A., Galkova, K., Garcia, I., Garner, M., Gasenkampf, A., Gelmanas, A., Gherghina, V., Gilsanz, F., Giokas, G., Goebel, U., Gomes, P., Gonçalves Aguiar, J., Gonzalez Monzon, V., Gottschalk, A., Gouraud, J., Gramigni, E., Grintescu, I., Grynyuk, A., Grytsan, A., Guasch, E., Gustin, D., Hans, G., Harazim, H., Hervig, T., Hidalgo, F., Higham, C., Hirschauer, N., Hoeft, A., Innerhofer, P., Innerhofer-Pompernigg, N., Jacobs, S., Jakobs, N., Jamaer, L., James, S., Jawad, M., Jesus, J., Jhanji, S., Jipa Lavina, N., Jokinen, J., Jovanovic, G., Jubera, M., Kahn, D., Karjagin, J., Kasnik, D., Katsanoulas, K., Kelle, H., Kelleher, M., Kessler, F., Kirigin, B., Kiskira, O., Kivik, P., Klimi, P., Klučka, J., Koers, L., Kontrimaviciut, E., Koopman-van Gemert, A., Korfiotis, D., Kosinová, M., Koursoumi, E., Kozek Langenecker, S., Kranke, P., Kresic, M., Krobot, R., Kropman, L., Kulikov, A., Kvolik, S., Kvrgic, I., Kyttari, A., Lagarto, F., Lance, M., Laufenberg, R., Lauwick, S., Lecoq, J., Leech, L., Lidzborski, L., Liliana, H., Linda, F., Lopes, A., Lopez, L., Lopez Alvarez, A., Lorenzi, I., Lorre, G., Lucian, H., Lupis, T., Lupu, M., Macas, A., Macedo, A., Maggi, G., Mallor, T., Manoleli, A., Manolescu, R., Manrique, S., Maquoi, I., Marios-Konstantinos, T., Markovic Bozic, J., Markus, W., Marques, M., Martinez, R., Martinez, E., Martínez, E., Martinho, H., Martins, D., Martires, E., Matias, F., Mauff, S., Meale, P., Merz, H., Meybohm, P., Militello, M., Mincu, N., Miranda, M., Mirea, L., Moghildea, V., Moise, A., Molano Diaz, P., Moltó, L., Monedero, P., Moral, V., Moreira, Z., Moret, E., Mulders, F., Munteanu, A., Nadia Diana, K., Nair, A., Neskovic, V., Ninane, V., Nitu, D., Oberhofer, D., Odeberg-Wernerman, S., Oganjan, J., Omur, D., Orallo Moran, M., Ozkardesler, S., Pacasová, R., Paklar, N., Pandazi, A., Papaspyros, F., Paraskeuopoulos, T., Parente, S., Paunescu, M., Pavičić Šarić, J., Pereira, F., Pereira, E., Pereira, L., Perry, C., Petri, A., Petrovic, U., Pica, S., Pinheiro, F., Pinto, J., Pinto, F., Piwowarczyk, P., Platteau, S., Poeira, R., Popescu, R., Popica, G., Poredos, P., Prasser, C., Preckel, B., Prospiech, A., Pujol, R., Raimundo, A., Raineri, S., Rakic, D., Ramadan, M., Ramazanoğlu, A., Rantis, A., Raquel, F., Rätsep, I., Real, C., Reikvam, T., Reis, L., Rigal, J., Rohner, A., Rokk, A., Roman Fernandez, A., Rosenberger, P., Rossaint, R., Rozec, B., Rudolph, T., Saeed, Y., Safonov, S., Saka, E., Samama, C., Sánchez López, Ó., Sanchez Perez, D., Sanchez Sanchez, Y., Sandeep, V., Sandu, M., Sanlı, S., Saraiva, A., Scarlatescu, E., Schiraldi, R., Schittek, G., Schnitter, B., Schuster, M., Seco, C., Selvi, O., Senard, M., Serra, S., Serrano, H., Shmigelsky, A., Silva, L., Simeson, K., Singh, R., Sipylaite, J., Skitek, K., Skok, I., Smékalová, O., Smirnova, N., Sofia, M., Soler Pedrola, M., Söndergaard, S., Sõrmus, A., Sørvoll, I., Soumelidis, C., Spindler Yesel, A., Stefan, M., Stevanovic, A., Stevikova, J., Stivan, S., Štourač, P., Striteska, J., Strys, L., Suljevic, I., Tania, M., Tareco, G., Tena, B., Theodoraki, K., Tifrea, M., Tikuisis, R., Tolós, R., Tomasi, R., Tomescu, D., Tomkute, G., Tormos, P., Trepenaitis, D., Troyan, G., Unic-Stojanovic, D., Unterrainer, A., Uranjek, J., Valsamidis, D., van Dasselaar, N., Van Limmen, J., van Noord, P., van Poorten, J., Vanderlaenen, M., Varela Garcia, O., Velasco, A., Veljovic, M., Vera Bella, J., Vercauteren, M., Verdouw, B., Verenkin, V., Veselovsky, T., Vieira, H., Villar, T., Visnja, I., Voje, M., von Dossow-Hanfstingl, V., Von Langen, D., Vorotyntsev, S., Vujanovič, V., Vukovic, R., Watt, P., Werner, E., Wernerman, J., Wittmann, M., Wright, M., Wunder, C., Wyffels, P., Yakymenko, Y., Yıldırım, Ç., Yılmaz, H., Zacharowski, K., Záhorec, R., Zarif, M., Zielinska-Skitek, E., Zsisku, L., Anesthesiology, Graduate School, ACS - Amsterdam Cardiovascular Sciences, and AII - Amsterdam institute for Infection and Immunity

Subjects
AUSTRIAN BENCHMARK, Male, Blood transfusion, medicine.medical_treatment, 610 Medizin, anaemia, anesthesia, blood transfusion, surgery, transfusion trigger, 030204 cardiovascular system & hematology, GUIDELINES, surgery, Cohort Studies, 0302 clinical medicine, 030202 anesthesiology, Medicine and Health Sciences, Medicine, Prospective Studies, Prospective cohort study, ddc:610, Research Support, Non-U.S. Gov't, Middle Aged, Hospitals, Europe, Female, Allogeneic transfusion, Cohort study, medicine.medical_specialty, Transfusion rate, Observational Study, anesthesia, blood transfusion, ELECTIVE SURGERY, Clinical Practice, 03 medical and health sciences, Journal Article, anaemia, transfusion trigger, Humans, Blood Transfusion, Elective surgery, CHLC ANS, Intensive care medicine, Intraoperative Care, business.industry, PREOPERATIVE ANEMIA, PATIENT BLOOD MANAGEMENT, Clinical trial, Anesthesiology and Pain Medicine, Emergency medicine, business, Packed red blood cells, REQUIREMENTS
Abstract

PubMed: 26787795, Background: Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe. Methods: We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013. Results: The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl-1 and increased to 9.8 (1.8) g dl-1 after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2). Conclusions: Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl-1), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold. © 2016 The Author. Published by Oxford University Press on behalf of the British Journal of Anaesthesia.

Published
2016

35. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Author

Mallick, S, Li, H, Lipson, M, Mathieson, I, Gymrek, M, Racimo, F, Zhao, M, Chennagiri, N, Nordenfelt, S, Tandon, A, Skoglund, P, Lazaridis, I, Sankararaman, S, Fu, Q, Rohland, N, Renaud, G, Erlich, Y, Willems, T, Gallo, C, Spence, JP, Song, YS, Poletti, G, Balloux, F, van Driem, G, de Knijff, P, Romero, IG, Jha, AR, Behar, DM, Bravi, CM, Capelli, C, Hervig, T, Moreno-Estrada, A, Posukh, OL, Balanovska, E, Balanovsky, O, Karachanak-Yankova, S, Sahakyan, H, Toncheva, D, Yepiskoposyan, L, Tyler-Smith, C, Xue, Y, Abdullah, MS, Ruiz-Linares, A, Beall, CM, Di Rienzo, A, Jeong, C, Starikovskaya, EB, Metspalu, E, Parik, J, Villems, R, Henn, BM, Hodoglugil, U, Mahley, R, Sajantila, A, Stamatoyannopoulos, G, Wee, JTS, Khusainova, R, Khusnutdinova, E, Litvinov, S, Ayodo, G, Comas, D, Hammer, MF, Kivisild, T, Klitz, W, Winkler, CA, Labuda, D, Bamshad, M, Jorde, LB, Tishkoff, SA, Watkins, WS, Metspalu, M, Dryomov, S, Sukernik, R, Singh, L, Thangaraj, K, Paeaebo, S, Kelso, J, Patterson, N, Reich, D, Mallick, S, Li, H, Lipson, M, Mathieson, I, Gymrek, M, Racimo, F, Zhao, M, Chennagiri, N, Nordenfelt, S, Tandon, A, Skoglund, P, Lazaridis, I, Sankararaman, S, Fu, Q, Rohland, N, Renaud, G, Erlich, Y, Willems, T, Gallo, C, Spence, JP, Song, YS, Poletti, G, Balloux, F, van Driem, G, de Knijff, P, Romero, IG, Jha, AR, Behar, DM, Bravi, CM, Capelli, C, Hervig, T, Moreno-Estrada, A, Posukh, OL, Balanovska, E, Balanovsky, O, Karachanak-Yankova, S, Sahakyan, H, Toncheva, D, Yepiskoposyan, L, Tyler-Smith, C, Xue, Y, Abdullah, MS, Ruiz-Linares, A, Beall, CM, Di Rienzo, A, Jeong, C, Starikovskaya, EB, Metspalu, E, Parik, J, Villems, R, Henn, BM, Hodoglugil, U, Mahley, R, Sajantila, A, Stamatoyannopoulos, G, Wee, JTS, Khusainova, R, Khusnutdinova, E, Litvinov, S, Ayodo, G, Comas, D, Hammer, MF, Kivisild, T, Klitz, W, Winkler, CA, Labuda, D, Bamshad, M, Jorde, LB, Tishkoff, SA, Watkins, WS, Metspalu, M, Dryomov, S, Sukernik, R, Singh, L, Thangaraj, K, Paeaebo, S, Kelso, J, Patterson, N, and Reich, D

Abstract

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.

Published
2016

37. A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment

Author

Knutson, Folke, Osselaer, J., Pierelli, L., Lozano, M., Cid, J., Tardivel, R., Garraud, O., Hervig, T., Domanovic, D., Cukjati, M., Gudmundson, S., Hjalmarsdottir, I. B., Castrillo, A., Gonzalez, R., Brihante, D., Santos, M., Schlenke, P., Elliott, A., Lin, J. -S, Tappe, D., Stassinopoulos, A., Green, J., Corash, L., Knutson, Folke, Osselaer, J., Pierelli, L., Lozano, M., Cid, J., Tardivel, R., Garraud, O., Hervig, T., Domanovic, D., Cukjati, M., Gudmundson, S., Hjalmarsdottir, I. B., Castrillo, A., Gonzalez, R., Brihante, D., Santos, M., Schlenke, P., Elliott, A., Lin, J. -S, Tappe, D., Stassinopoulos, A., Green, J., and Corash, L.

Abstract

Background and Objectives A photochemical treatment process (PCT) utilizing amotosalen and UVA light (INTERCEPT (TM) Blood System) has been developed for inactivation of viruses, bacteria, parasites and leucocytes that can contaminate blood components intended for transfusion. The objective of this study was to further characterize the safety profile of INTERCEPT-treated platelet components (PCT-PLT) administered across a broad patient population. Materials and Methods This open-label, observational haemovigilance programme of PCT-PLT transfusions was conducted in 21 centres in 11 countries. All transfusions were monitored for adverse events within 24 h post-transfusion and for serious adverse events (SAEs) up to 7 days post-transfusion. All adverse events were assessed for severity (Grade 0-4), and causal relationship to PCT-PLT transfusion. Results Over the course of 7 years in the study centres, 4067 patients received 19 175 PCT-PLT transfusions. Adverse events were infrequent, and most were of Grade 1 severity. On a per-transfusion basis, 123 (0.6%) were classified an acute transfusion reaction (ATR) defined as an adverse event related to the transfusion. Among these ATRs, the most common were chills (77, 0.4%) and urticaria (41, 0.2%). Fourteen SAEs were reported, of which 2 were attributed to platelet transfusion (<0.1%). No case of transfusion-related acute lung injury, transfusion-associated graft-versus-host disease, transfusion-transmitted infection or death was attributed to the transfusion of PCT-PLT. Conclusion This longitudinal haemovigilance safety programme to monitor PCT-PLT transfusions demonstrated a low rate of ATRs, and a safety profile consistent with that previously reported for conventional platelet components.

Published
2015
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38. A prospective, active haemovigilance study with combined cohort analysis of 19,175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Centre de transfusion sanguine, Knutson, F, Osselaer, Jean-Claude, Pierelli, L, Lozano, M, Cid, J, Tardivel, R, Garraud, O, Hervig, T, Domanovic, D, Cukjati, M, Gudmundson, S, Hjalmarsdottir, I B, Castrillo, A, Gonzalez, R, Brihante, D, Santos, M, Schlenke, P, Elliott, A, Lin, J-S, Tappe, D, Stassinopoulos, A, Green, J, Corash, L, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Centre de transfusion sanguine, Knutson, F, Osselaer, Jean-Claude, Pierelli, L, Lozano, M, Cid, J, Tardivel, R, Garraud, O, Hervig, T, Domanovic, D, Cukjati, M, Gudmundson, S, Hjalmarsdottir, I B, Castrillo, A, Gonzalez, R, Brihante, D, Santos, M, Schlenke, P, Elliott, A, Lin, J-S, Tappe, D, Stassinopoulos, A, Green, J, and Corash, L

Abstract

BACKGROUND AND OBJECTIVES: A photochemical treatment process (PCT) utilizing amotosalen and UVA light (INTERCEPT(™) Blood System) has been developed for inactivation of viruses, bacteria, parasites and leucocytes that can contaminate blood components intended for transfusion. The objective of this study was to further characterize the safety profile of INTERCEPT-treated platelet components (PCT-PLT) administered across a broad patient population. MATERIALS AND METHODS: This open-label, observational haemovigilance programme of PCT-PLT transfusions was conducted in 21 centres in 11 countries. All transfusions were monitored for adverse events within 24 h post-transfusion and for serious adverse events (SAEs) up to 7 days post-transfusion. All adverse events were assessed for severity (Grade 0-4), and causal relationship to PCT-PLT transfusion. RESULTS: Over the course of 7 years in the study centres, 4067 patients received 19,175 PCT-PLT transfusions. Adverse events were infrequent, and most were of Grade 1 severity. On a per-transfusion basis, 123 (0.6%) were classified an acute transfusion reaction (ATR) defined as an adverse event related to the transfusion. Among these ATRs, the most common were chills (77, 0.4%) and urticaria (41, 0.2%). Fourteen SAEs were reported, of which 2 were attributed to platelet transfusion (<0.1%). No case of transfusion-related acute lung injury, transfusion-associated graft-versus-host disease, transfusion-transmitted infection or death was attributed to the transfusion of PCT-PLT. CONCLUSION: This longitudinal haemovigilance safety programme to monitor PCT-PLT transfusions demonstrated a low rate of ATRs, and a safety profile consistent with that previously reported for conventional platelet components.

Published
2015

39. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

Author

Busby, Gbj, Hellenthal, G, Montinaro, F, Tofanelli, S, Bulayeva, K, Rudan, I, Zemunik, T, Hayward, C, Toncheva, D, Karachanak Yankova, S, Nesheva, D, Anagnostou, P, Cali, F, Brisighelli, Francesca, Romano, V, Lefranc, G, Buresi, C, Ben Chibani, J, Haj Khelil, A, Denden, S, Ploski, R, Krajewski, P, Hervig, T, Moen, T, Herrera, Rj, Wilson, Jf, Myers, S, Capelli, C., Brisighelli, Francesca (ORCID:0000-0001-5469-4413), Busby, Gbj, Hellenthal, G, Montinaro, F, Tofanelli, S, Bulayeva, K, Rudan, I, Zemunik, T, Hayward, C, Toncheva, D, Karachanak Yankova, S, Nesheva, D, Anagnostou, P, Cali, F, Brisighelli, Francesca, Romano, V, Lefranc, G, Buresi, C, Ben Chibani, J, Haj Khelil, A, Denden, S, Ploski, R, Krajewski, P, Hervig, T, Moen, T, Herrera, Rj, Wilson, Jf, Myers, S, Capelli, C., and Brisighelli, Francesca (ORCID:0000-0001-5469-4413)

Abstract

Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-scale, dynamic population movements over the last 10,000 years, such that ancestry across present-day populations is likely to be a mixture of several ancient groups [1-7]. While these efforts are bringing the details of West Eurasian prehistory into increasing focus, studies aimed at understanding the processes behind the generation of the current West Eurasian genetic landscape have been limited by the number of populations sampled or have been either too regional or global in their outlook [8-11]. Here, using recently described haplotype-based techniques [11], we present the results of a systematic survey of recent admixture history across Western Eurasia and show that admixture is a universal property across almost all groups. Admixture in all regions except North Western Europe involved the influx of genetic material from outside of West Eurasia, which we date to specific time periods. Within Northern, Western, and Central Europe, admixture tended to occur between local groups during the period 300 to 1200 CE. Comparisons of the genetic profiles of West Eurasians before and after admixture show that population movements within the last 1,500 years are likely to have maintained differentiation among groups. Our analysis provides a timeline of the gene flow events that have generated the contemporary genetic landscape of West Eurasia.

Published
2015

40. A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen–UVAphotochemical treatment

Author

Knutson, F., primary, Osselaer, J., additional, Pierelli, L., additional, Lozano, M., additional, Cid, J., additional, Tardivel, R., additional, Garraud, O., additional, Hervig, T., additional, Domanovic, D., additional, Cukjati, M., additional, Gudmundson, S., additional, Hjalmarsdottir, I. B., additional, Castrillo, A., additional, Gonzalez, R., additional, Brihante, D., additional, Santos, M., additional, Schlenke, P., additional, Elliott, A., additional, Lin, J.‐S., additional, Tappe, D., additional, Stassinopoulos, A., additional, Green, J., additional, and Corash, L., additional

Published
2015
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42. Ancient human genomes suggest three ancestral populations for present-day Europeans

Author

Lazaridis, I, Patterson, N, Mittnik, A, Renaud, G, Mallick, S, Kirsanow, K, Sudmant, Ph, Schraiber, Jg, Castellano, S, Lipson, M, Berger, B, Economou, C, Bollongino, R, Fu, Q, Bos, Ki, Nordenfelt, S, Li, H, De Filippo, C, Prüfer, K, Sawyer, S, Posth, C, Haak, W, Hallgren, F, Fornander, E, Rohland, N, Delsate, D, Francken, M, Guinet, Jm, Wahl, J, Ayodo, G, Babiker, Ha, Bailliet, G, Balanovska, E, Balanovsky, O, Bedoya, G, Ben Ami, H, Bene, J, Berrada, F, Bravi, Cm, Brisighelli, Francesca, Busby, Gb, Cali, F, Churnosov, M, Cole, De, Corach, D, Damba, L, Van Driem, G, Dryomov, S, Fedorova, Sa, Gallego Romero, I, Gubina, M, Hammer, M, Henn, Bm, Hervig, T, Hodoglugil, U, Jha, Ar, Karachanak Yankova, S, Khusainova, R, Khusnutdinova, E, Kittles, R, Kivisild, T, Kučinskas, V, Kushniarevich, A, Laredj, L, Litvinov, S, Loukidis, T, Mahley, Rw, Melegh, B, Metspalu, E, Molina, J, Mountain, J, Näkkäläjärvi, K, Nesheva, D, Nyambo, T, Osipova, L, Platonov, F, Posukh, O, Romano, V, Rothhammer, F, Rudan, I, Ruizbakiev, R, Sahakyan, H, Sajantila, A, Salas, A, Starikovskaya, Eb, Tarekegn, A, Toncheva, D, Turdikulova, S, Utevska, O, Vasquez, R, Villena, M, Voevoda, M, Winkler, Ca, Yepiskoposyan, L, Zalloua, P, Zemunik, T, Cooper, A, Capelli, C, Ruiz Linares, A, Tishkoff, Sa Et Al, Brisighelli, Francesca (ORCID:0000-0001-5469-4413), Lazaridis, I, Patterson, N, Mittnik, A, Renaud, G, Mallick, S, Kirsanow, K, Sudmant, Ph, Schraiber, Jg, Castellano, S, Lipson, M, Berger, B, Economou, C, Bollongino, R, Fu, Q, Bos, Ki, Nordenfelt, S, Li, H, De Filippo, C, Prüfer, K, Sawyer, S, Posth, C, Haak, W, Hallgren, F, Fornander, E, Rohland, N, Delsate, D, Francken, M, Guinet, Jm, Wahl, J, Ayodo, G, Babiker, Ha, Bailliet, G, Balanovska, E, Balanovsky, O, Bedoya, G, Ben Ami, H, Bene, J, Berrada, F, Bravi, Cm, Brisighelli, Francesca, Busby, Gb, Cali, F, Churnosov, M, Cole, De, Corach, D, Damba, L, Van Driem, G, Dryomov, S, Fedorova, Sa, Gallego Romero, I, Gubina, M, Hammer, M, Henn, Bm, Hervig, T, Hodoglugil, U, Jha, Ar, Karachanak Yankova, S, Khusainova, R, Khusnutdinova, E, Kittles, R, Kivisild, T, Kučinskas, V, Kushniarevich, A, Laredj, L, Litvinov, S, Loukidis, T, Mahley, Rw, Melegh, B, Metspalu, E, Molina, J, Mountain, J, Näkkäläjärvi, K, Nesheva, D, Nyambo, T, Osipova, L, Platonov, F, Posukh, O, Romano, V, Rothhammer, F, Rudan, I, Ruizbakiev, R, Sahakyan, H, Sajantila, A, Salas, A, Starikovskaya, Eb, Tarekegn, A, Toncheva, D, Turdikulova, S, Utevska, O, Vasquez, R, Villena, M, Voevoda, M, Winkler, Ca, Yepiskoposyan, L, Zalloua, P, Zemunik, T, Cooper, A, Capelli, C, Ruiz Linares, A, Tishkoff, Sa Et Al, and Brisighelli, Francesca (ORCID:0000-0001-5469-4413)

Abstract

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

Published
2014

43. Experiences with semi-routine production of riboflavin and UV-B pathogen-inactivated platelet concentrates in three blood centres.

Author

Meer, P. F., Couture, C., Hervig, T., Kruit, G., Devine, D. V., Korte, D., and Kerkhoffs, J.‐L.

Subjects
BLOOD platelets, BLOOD products, BLOOD substitutes, PLASMA products, BLOOD cells
Abstract

Background For a clinical platelet ( PLT) transfusion trial conducted in three countries, the production of PLT concentrates ( PCs) that were pathogen inactivated with the Mirasol technology was set up and validated. While the Mirasol procedure is applied to an established PLT product, the PLT processing procedure still had to be modified to ensure a treated PC was of sufficient quality. Further, the effect of simulated transport conditions and the effect of ambient light on Mirasol-treated PCs was determined. Study Design and Methods Platelet concentrates in plasma were made from pooled buffy coats followed by Mirasol treatment. To mimic transport conditions, units were left unagitated for 6 h at room temperature. To mimic ambient light exposure, units were held unagitated for 4 h in direct fluorescent tube light. Results Measures had to be taken to allow 7-day storage of treated concentrates. In one site, PCs made from five buffy coats with >450 × 109 PLTs were removed from inventory. Another site went from five to four buffy coats per pool. Interruption of agitation for 6 h on day 3 did not induce meaningful changes in in vitro measures, even when stored up to 7 days. Exposure to ambient light for 4 h, either on day 3 or 6, had no effect on in vitro measures. Conclusion The Mirasol pathogen inactivation process can be implemented in routine, but changes to current PLT processing methods might be needed. Transport conditions and 4-h-long ambient light exposure have no negative effect on the in vitro quality of Mirasol-treated PCs. [ABSTRACT FROM AUTHOR]

Published
2017
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44. The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269

Author

Busby, Gbj, Brisighelli, Francesca, Sanchez Diz, P, Ramos Luis, E, Martinez Cadenas, C, Thomas, Mg, Bradley, Dg, Gusmao, L, Winney, B, Bodmer, W, Vennemann, M, Coia, V, Scarnicci, F, Tofanelli, S, Vona, G, Ploski, R, Vecchiotti, C, Zemunik, T, Rudan, I, Karachanak, S, Toncheva, D, Anagnostou, P, Ferri, G, Rapone, C, Hervig, T, Moen, T, Wilson, Jf, Capelli, C., Brisighelli, Francesca (ORCID:0000-0001-5469-4413), Busby, Gbj, Brisighelli, Francesca, Sanchez Diz, P, Ramos Luis, E, Martinez Cadenas, C, Thomas, Mg, Bradley, Dg, Gusmao, L, Winney, B, Bodmer, W, Vennemann, M, Coia, V, Scarnicci, F, Tofanelli, S, Vona, G, Ploski, R, Vecchiotti, C, Zemunik, T, Rudan, I, Karachanak, S, Toncheva, D, Anagnostou, P, Ferri, G, Rapone, C, Hervig, T, Moen, T, Wilson, Jf, Capelli, C., and Brisighelli, Francesca (ORCID:0000-0001-5469-4413)

Abstract

Recently, the debate on the origins of the major European Y chromosome haplogroup R1b1b2-M269 has reignited, and opinion has moved away from Palaeolithic origins to the notion of a younger Neolithic spread of these chromosomes from the Near East. Here, we address this debate by investigating frequency patterns and diversity in the largest collection of R1b1b2-M269 chromosomes yet assembled. Our analysis reveals no geographical trends in diversity, in contradiction to expectation under the Neolithic hypothesis, and suggests an alternative explanation for the apparent cline in diversity recently described. We further investigate the young, STR-based time to the most recent common ancestor estimates proposed so far for R-M269-related lineages and find evidence for an appreciable effect of microsatellite choice on age estimates. As a consequence, the existing data and tools are insufficient to make credible estimates for the age of this haplogroup, and conclusions about the timing of its origin and dispersal should be viewed with a large degree of caution

Published
2011

45. Monitoring and treatment of anti-D in pregnancy.

Author

Bettelheim, D., Panzer, S., Reesink, H.W., Csapo, B., Pessoa, C., Guerra, F., Wendel, S., Calda, P., Sprogoe, U., Dziegiel, M., Aitokallio-Tallberg, A., Koskinen, S., Kuosmanen, M., Legler, T.J., Stein, W., Villa, S., Villa, M.A., Trespidi, L., Acaia, B., Vandenbussche, F.P.H.A., Brand, A., Haas, M. de, Kanhai, H.H.H., Gounder, D., Flanagan, P., Donegan, R., Parry, E., Sefonte, C., Skulstad, S.M., Hervig, T., Flesland, O., Zupanska, B., Uhryonowska, M., Lapaire, O., Zhong, X.Y., Holzgreve, W., Bettelheim, D., Panzer, S., Reesink, H.W., Csapo, B., Pessoa, C., Guerra, F., Wendel, S., Calda, P., Sprogoe, U., Dziegiel, M., Aitokallio-Tallberg, A., Koskinen, S., Kuosmanen, M., Legler, T.J., Stein, W., Villa, S., Villa, M.A., Trespidi, L., Acaia, B., Vandenbussche, F.P.H.A., Brand, A., Haas, M. de, Kanhai, H.H.H., Gounder, D., Flanagan, P., Donegan, R., Parry, E., Sefonte, C., Skulstad, S.M., Hervig, T., Flesland, O., Zupanska, B., Uhryonowska, M., Lapaire, O., Zhong, X.Y., and Holzgreve, W.

Abstract

Item does not contain fulltext

Published
2010

46. Monitoring and treatment of anti-D in pregnancy

Author

Bettelheim, D, Panzer, S, Reesink, H W, Csapo, B, Pessoa, C, Guerra, F, Wendel, S, Calda, P, Sprogøe, U, Dziegiel, M, Aitokallio-Tallberg, A, Koskinen, S, Kuosmanen, M, Legler, T J, Stein, W, Villa, S, Villa, M A, Trespidi, L, Acaia, B, Vandenbussche, F P H A, Brand, A, de Haas, M, Kanhai, H H H, Gounder, D, Flanagan, P, Donegan, R, Parry, E, Sefonte, C, Skulstad, S M, Hervig, T, Flesland, Ø, Zupanska, B, Uhrynowska, M, Lapaire, O, Zhong, X Y, Holzgreve, W, Bettelheim, D, Panzer, S, Reesink, H W, Csapo, B, Pessoa, C, Guerra, F, Wendel, S, Calda, P, Sprogøe, U, Dziegiel, M, Aitokallio-Tallberg, A, Koskinen, S, Kuosmanen, M, Legler, T J, Stein, W, Villa, S, Villa, M A, Trespidi, L, Acaia, B, Vandenbussche, F P H A, Brand, A, de Haas, M, Kanhai, H H H, Gounder, D, Flanagan, P, Donegan, R, Parry, E, Sefonte, C, Skulstad, S M, Hervig, T, Flesland, Ø, Zupanska, B, Uhrynowska, M, Lapaire, O, Zhong, X Y, and Holzgreve, W

Abstract

Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the incidence of anti-D immunization in many "developed" countries. Therefore, this forum focuses on prenatal monitoring standards and treatment strategies in pregnancies with anti-D alloimmunization. The following questions were addressed, and a response was obtained from 12 centres, mainly from Europe.

Published
2010

48. Monitoring and treatment of anti-D in pregnancy

Author

Bettelheim, D., primary, Panzer, S., additional, Reesink, H. W., additional, Csapo, B., additional, Pessoa, C., additional, Guerra, F., additional, Wendel, S., additional, Calda, P., additional, Sprogøe, U., additional, Dziegiel, M., additional, Aitokallio-Tallberg, A., additional, Koskinen, S., additional, Kuosmanen, M., additional, Legler, T. J., additional, Stein, W., additional, Villa, S., additional, Villa, M. A., additional, Trespidi, L., additional, Acaia, B., additional, Vandenbussche, F. P. H. A., additional, Brand, A., additional, De Haas, M., additional, Kanhai, H. H. H., additional, Gounder, D., additional, Flanagan, P., additional, Donegan, R., additional, Parry, E., additional, Sefonte, C., additional, Skulstad, S. M., additional, Hervig, T., additional, Flesland, Ø., additional, Żupańska, B., additional, Uhrynowska, M., additional, Lapaire, O., additional, Zhong, X. Y., additional, and Holzgreve, W., additional

Published
2010
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