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Latar belakang. Insiden sepsis pada negara berkembang sampai saat ini masih tinggi. Banyaknya faktor risiko yang memengaruhi, menjadikan sepsis sebagai penyumbang tingginya angka kematian pada bayi. Diagnosis yang seringkali terlambat ditegakkan karena pemeriksaan kultur darah sebagai Gold Standard baru bisa didapatkan hasilnya setelah beberapa hari. Deteksi dini sepsis neonatorum dapat diltegakkan salah satunya dengan pemeriksaan rasio neutrofil limfosit dan red cell distribution width. Tujuan. Menilai rasio neutrofil limfosit, red cell distribution width, dan faktor risiko pada neonatus dengan diagnosis sepsis di neonatal intensive care unit - NICU Rumah Sakit Zainoel Abidin Banda Aceh dengan luaran kematian. Metode. Penelitian desain kohort retrospektif dengan data rekam medis neonatus di NICU Rumah Sakit Umum Daerah Dr. Zainoel Abidin, Banda Aceh, dari Februari hingga Oktober 2023. Sebanyak 43 neonatus dengan diagnosis sepsis yang memenuhi kriteria inklusi dianalisis. Data yang dikumpulkan meliputi karakteristik demografis, hasil laboratorium, serta luaran klinis. Analisis dilakukan menggunakan uji Chi-square dan analisis multivariat dengan SPSS versi 20.0. Hasil. Diperoleh 88,3% neonatus menunjukkan peningkatan NLR, dan 86,05% mengalami peningkatan RDW. Terdapat hubungan signifikan antara metode persalinan sectio caesaria (p

Latar belakang. Respiratory Distress Syndrome merupakan penyebab gangguan pernapasan, sering terjadi pada bayi baru lahir dan juga menjadi penyebab paling umum terjadinya morbiditas dan mortalitas pada neonatus. Salah satu komplikasi yang sering terjadi adalah Acute Kidney Injury. Tujuan. Penelitian ini bertujuan untuk menganalisis hubungan antara Respiratory Distress Syndrome dengan kejadian Acute kidney injury pada neonatus di Rumah Sakit dr. Zainoel Abidin Banda Aceh. Metode. Penelitian ini menggunakan pendekatan analitik obervasional dengan desain cross-sectional. Data dikumpulkan dari pasien yang dirawat dalam periode Januari 2021-Desember 2021. Sampel penelitian adalah populasi terjangkau yang memenuhi kriteria inklusi dan eksklusi. Besar sampel penelitian adalah total populasi. Penelitian bersifat retrospektif dengan variabel dependen dan independen yang diamati secara sekaligus. Hasil. Selama penelitian berlangsung didapatkan 50 sampel yang memenuhi kriteria inklusi dan eksklusi penelitian, jumlah neonatus berjenis kelamin laki-laki (50%) sebanding dengan perempuan (50%). Usia neonatus terbanyak pada kelompok 3 hari yakni 36 subjek (72%). Mayoritas jenis persalinan dijumpai pada kelompok sectio caesarea yakni 45 subjek (90%). Kelompok usia gestasi 34-36 minggu (preterm) terbanyak yakni 32 subjek (64%). Subjek kelompok Berat badan lahir 1000-7 berhubungan dengan kejadian Acute Kidney Injury. Mayoritas subjek penelitian dengan Respiratory Distress Syndrom tidak dijumpai Acute Kidney Injury, sebanyak 39 subjek (78%) dengan hasil normal. Kesimpulan. Pada penelitian ini didapatkan terdapat hubungan antara Respiratory Distress Syndrom dengan kejadian Acute Kidney Injury (p

Background Acute kidney injury (AKI) in sepsis is associated with an inflammatory process in kidney microcirculation and may increase morbidity and mortality in children. The neutrophil lymphocyte ratio (NLR) is an inflammatory biomarker of the inflammatory process in sepsis. Objective To determine the role of NLR in predicting the severity of AKI and to describe the demographic and laboratory characteristics, as they relate to outcomes of pediatric patients with AKI and sepsis. Methods This cross-sectional study was conducted in the PICU at Dr. Zainoel Abidin General Hospital (RSUDZA), Banda Aceh, Aceh. Medical record data were obtained from critically ill children with sepsis and AKI. Chi-square test was used to compare the proportions of each variable. We also calculated odds ratios to evaluate the AKI severity, PELOD-2 score, and patient outcomes. Spearman's analysis was used to look for a possible correlation between NLR and AKI severity in septic children. Results Seventy-one subjects with sepsis and AKI were included. Subject characteristics were as follows: 63.4% males, 63.4% < 1 year of age, 56.3% with respiratory problems as a primary disease, 38% with AKI injury stage, and 54.9% subjects with PELOD-2 score ?10. There was no significant correlation between AKI severity and mortality (OR 3.04; 95%CI 0.990 to 9.378; P=0.052). Subjects with a PELOD-2 score ?10 had a 47.6 times higher chance of mortality in septic children with AKI compared to those with PELOD-2 scores

Background Parents usually make the decisions on COVID-19 vaccinations for their children under the age of 18. Objective To explore parents' perceptions and expectations of COVID-19 vaccination for children in Banda Aceh. Methods This study used a qualitative design with a phenomenological approach. Data were collected through in-depth interviews of 36 parents in Banda Aceh. The data were analyzed qualitatively through thematic analysis. Results Three themes were studied: (1) perceptions of parents willing to have their children vaccinated against COVID-19, (2) perceptions of parents who refused or delayed their children’s vaccination against COVID-19, and (3) parents' expectations regarding COVID-19 vaccination in children. Benefits of the vaccine and government policy were among the reasons that parents were willing to have their children vaccinated. Vaccine safety concerns, lack of information, strong immunity, healthy lifestyle, and religious beliefs were the main reasons for parental refusal or delay in vaccinating their children. Reduced cases of COVID-19 and the end of the pandemic, not being infected, developing immunity, and no adverse events following immunization, face-to-face learning in schools, as well as increased education and socialization from the government, society that was critical and selective in receiving information were the expectation of parents regarding COVID-19 vaccination in children. Conclusion The perception of vaccine benefits and government policy influence parents to have their children vaccinated, while perception of vaccine safety concerns, lack of information, strong immunity, healthy lifestyle, and religious beliefs influence parents to refuse or delay their children being vaccinated. Parents' expectations regarding COVID-19 illness, their children’s response to the vaccine and education, as well as the government’s and society’s roles during the pandemic are qualitatively elucidated.

Latar belakang. Sindrom rubela kongenital adalah kumpulan gejala akibat infeksi virus rubela selama kehamilan, ditandai trias klasik manifestasi klinis berupa sensory neural hearing loss, abnormalitas ocular, dan penyakit jantung bawaan. Pendekatan diagnosis ditegakkan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Diagnosis pasti berdasarkan hasil serologi anti rubela. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara penyakit jantung bawaan dengan konfirmasi serologi positif antibodi rubela pada sangkaan sindrom rubela kongenital. Metode. Penelitian ini menggunakan data sekunder Rekam Medis anak usia

Background Excess iron deriving from a chronic transfusion and dietary intake increases the risk for cardiac complications in β-thalassemia major patients. Deferiprone and deferasirox are commonly prescribed to thalassemic patients who are at risk of iron overload. This study aimed to compare the performance and toxicity of deferiprone and deferasirox in β-thalassemia major patients. Methods A cross-sectional observation was performed on 102 patients with β-thalassemia major. Serum ferritin along with total, indirect, and direct bilirubin levels were measured. Levels of liver enzymes, transaminase (ALT), and aspartate transaminase (AST), were also determined. Ferritin correlations with serum ALT, AST, and total bilirubin were constructed based on Spearman’s rank correlation. Statistical differences based on the serum parameters were analyzed between deferiprone and deferasirox groups. The differences of iron chelators’ effects between those receiving short-term (≤7 years) and long-term (>7 years) blood transfusion were also analyzed. Results The averaged levels of bilirubin, ALT, AST, and ferritin were found to be high. Ferritin was positively correlated with ALT (r=0.508 and p

Latar belakang. Hemangioma infantil merupakan salah satu tumor jinak pada bayi dan anak yang diawali dengan bentuk noda kemerahan. Pada masa proliferasi, noda kemerahan ini dapat berubah menjadi bentuk nodul atau melebar serta membesar. Hingga saat ini belum ada terapi yang memuaskan, dan terapi dengan kortikosteroid sistemik merupakan pilihan yang mudah dan efektif meskipun hasilnya tidak seragam. Terapi alternatif lain telah dicoba yaitu vincristin atau interfensi alfa. Tujuan Penelitian. Mengetahui sebaran, gambaran, komplikasi hemangioma serta mengevaluasi terapi kortikosteroid dan vincristine pada HI serta efek sampingnya. Metode. Analisis retrospektif terhadap 26 pasien yang berobat jalan di Poliklinik Khusus Hematologi Onkologi Anak Fakultas Kedokteran Universitas Indonesia, rumah sakit Dr. Ciptomangunkusumo Jakarta mulai tahun 2005 – 2006, hasil terapi dinilai berdasarkan mengecilnya hemangioma. Hasil. Hemangioma lebih banyak pada anak perempuan dengan bentuk morfologi segmental. Enam puluh sembilan persen hemangioma timbul setelah lahir dan terapi kortikosteroid diberikan terhadap 92% pasien, baik secara oral, maupun kombinasi suntikan intralesi atau dengan vincristine. Sebanyak 50% pasien mengalami perbaikan termasuk semua pasien yang diterapi kortikosteroid kombinasi dengan vincristine. Tidak ditemukan efek samping lokal, maupun sistemik akibat pemakaian kortikosteroid dan vincristin. Kesimpulan. Kortikosteroid sistemik dan intralesi cukup efektif sebagai pengobatan HI, yaitu dengan pengecilan hemangioma serta tidak ditemukannya efek samping sistemik lokal, maupun sistemik . Vincristin dapat dipakai sebagai alternatif pengobatan HI yang resisten terhadap kortikosteroid

Background Excess iron deriving from a chronic transfusion and dietary intake increases the risk for cardiac complications in β-thalassemia major patients. Deferiprone and deferasirox are commonly prescribed to thalassemic patients who are at risk of iron overload. This study aimed to compare the performance and toxicity of deferiprone and deferasirox in β-thalassemia major patients. Methods A cross-sectional observation was performed on 102 patients with β-thalassemia major. Serum ferritin along with total, indirect, and direct bilirubin levels were measured. Levels of liver enzymes, transaminase (ALT), and aspartate transaminase (AST), were also determined. Ferritin correlations with serum ALT, AST, and total bilirubin were constructed based on Spearman’s rank correlation. Statistical differences based on the serum parameters were analyzed between deferiprone and deferasirox groups. The differences of iron chelators’ effects between those receiving short-term (≤7 years) and long-term (>7 years) blood transfusion were also analyzed. Results The averaged levels of bilirubin, ALT, AST, and ferritin were found to be high. Ferritin was positively correlated with ALT (r=0.508 and pp=0.776). However, higher total bilirubin and ALT were observed in the deferasirox group than in the deferiprone group ( p=0.001 and 0.022, respectively). Total ( ppp=0.015) were significantly higher in patients with long-term transfusions than those receiving short-term transfusions. Higher ferritin was found with a statistical significance of p=0.008 in the long-term transfusions group. Conclusions Ferritin is high in people with transfusion-dependent β-thalassemia major and positively correlated with ALT and AST. Deferasirox might pose a higher risk of developing hepatic injury as compared with deferiprone. Yet, no significant change of deferasirox efficacy (based on ferritin level) was found between those receiving short-term and long-term transfusions.

Background: Excess iron deriving from a chronic transfusion and dietary intake increases the risk for cardiac complications in β-thalassemia major patients. Deferiprone and deferasirox are commonly prescribed to thalassemic patients who are at risk of iron overload. This study aimed to compare the performance and toxicity of deferiprone and deferasirox in β-thalassemia major patients. Methods: A cross-sectional observation was performed on 102 patients with β-thalassemia major. Serum ferritin along with total, indirect, and direct bilirubin levels were measured. Levels of liver enzymes, transaminase (ALT), and aspartate transaminase (AST), were also determined. Ferritin correlations with serum ALT, AST, and total bilirubin were constructed based on Spearman’s rank correlation. Statistical differences based on the serum parameters were analyzed between deferiprone and deferasirox groups. The differences of iron chelators’ effects between those receiving short-term (≤7 years) and long-term (>7 years) blood transfusion were also analyzed. Results: The averaged levels of bilirubin, ALT, AST, and ferritin were found to be high. Ferritin was positively correlated with ALT (r=0.508 and pp=0.776). However, higher total bilirubin and ALT were observed in the deferasirox group than in the deferiprone group ( p=0.001 and 0.022, respectively). Total ( ppp=0.015) were significantly higher in patients with long-term transfusions than those receiving short-term transfusions. Higher ferritin was found with a statistical significance of p=0.008 in the long-term transfusions group. Conclusions: Ferritin is high in people with transfusion-dependent β-thalassemia major and positively correlated with ALT and AST. Deferasirox might pose a higher risk of developing hepatic injury as compared with deferiprone. Yet, no significant change of deferasirox efficacy (based on ferritin level) was found between those receiving short-term and long-term transfusions.