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Based on the equilibrium geometries of [ Cu2( dbdmed)2 O2]2+ and [ Cu2( en)2 O2]2+ obtained within density-functional theory, we investigate their molecular electronic structure and optical response. Thereby results from occupation-constrained as well as time-dependent DFT (ΔSCF and TDDFT) are compared with Green's function-based approaches within many-body perturbation theory such as the GW approximation (GWA) to the quasiparticle energies and the Bethe-Salpeter equation (BSE) approach to the optical absorption. Concerning the ground-state energies and geometries, no clear trend with respect to the amount of exact exchange in the DFT calculations is found, and a strong dependence on the basis sets is to be noted. They affect the energy difference between bis-μ-oxo and μ-η2:η2-peroxo complexes by as much as 0.8 eV (18 kcal/mol). Even stronger, up to 5 eV is the influence of the exchange-correlation functional on the gap values obtained from the Kohn-Sham eigenvalues. Not only the value itself but also the trends observed upon the bis-μ-oxo to μ-η2:η2-peroxo transition are affected. In contrast, excitation energies obtained from ΔSCF and TDDFT are comparatively robust with respect to the details of the calculations. Noteworthy, in particular, is the near quantitative agreement between TDDFT and GWA+BSE for the optical spectra of [ Cu2( en)2 O2]2+. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Copper complexes of tripodal ligands have been used as model systems for electron transfer proteins for decades, displaying a broad range of electron self-exchange rates. We herein report a group of six tripodal tetradentate triarylamine ligands which display a varying number of guanidine and 2-methylquinolinyl moieties. Their corresponding Cu(I) complexes have been (re)synthesized and studied with regard to their electron transfer properties. While their molecular structures in the solid state are four-coordinate and display an uncommon umbrella distortion, DFT studies of the Cu(II) systems reveal that they gain an additional ligand in the form of a solvent molecule and exhibit a range of possible conformers that likely co-exist in thermal equilibrium. The redox-couples' electron self-exchange rates were analyzed using Marcus theory and vary over four orders of magnitude which cyclic voltammetry studies suggest to be due to a gated addition-oxidation electron transfer mechanism. This mechanism deviates from previously studied systems, likely due to the structural anomalies of the Cu(I) systems. This demonstrates that the chosen path of tripodal model systems can be influenced by molecular design.

The InChI (International Chemical Identifier) standard stands as a cornerstone in chemical informatics, facilitating the structure-based identification and exchange chemical information about compounds across various platforms and databases. The InChI as a unique canonical line notation has made chemical structures searchable on the internet at a broad scale. The largest repositories working with InChIs contain more than 1 billion structures. Central to the functionality of the InChI is its codebase, which orchestrates a series of intricate steps to generate unique identifiers for chemical compounds. Up to now, these steps have been sparsely documented and the InChI algorithm had to be seen as a black box. For the new v1.07 release, the code has been analyzed and the major steps documented, more than 3000 bugs and security issues, as well as nearly 60 Google OSS-Fuzz issues have been fixed. New test systems have been implemented that allow users to directly test the code developments. The move to GitHub has not only made the development more transparent but will also enable external contributors to join the further development of the InChI code. Motivation for this modernisation was the urgency to treat molecular inorganic compounds by the InChI in a meaningful way. Until now, no classic string representation fulfills this need of molecular inorganic chemistry. Currently bonds to metal centers are by definition disconnected which makes most inorganic InChIs meaningless at the moment. Herein, we propose new routines to remedy this problem in the representation of molecular inorganic compounds by the InChI.

In this study, the aliphatic N,N-bisguanidine zinc complex [Zn(DMEG 2 ch) 2 ](OTf) 2  ⋅ THF is introduced as a promising candidate for the chemical recycling of (bio) polyesters. This catalyst is highly active in the ring-opening polymerization (ROP) of lactide (LA) and ϵ-caprolactone (CL). The combination of polymerization and depolymerization activity creates new pathways towards a sustainable circular economy. The catalytic activity of [Zn(DMEG 2 ch) 2 ](OTf) 2  ⋅ THF for the chemical recycling of polylactide (PLA) via alcoholysis was investigated by detailed kinetic and thermodynamic studies. It is shown that various high value-added alkyl lactates can be obtained efficiently under mild reaction conditions. Catalyst recycling was successfully tested using ethanol for the degradation of PLA. In addition, LA can be recovered directly from PLA, enabling either open- or closed-loop recycling. Selective PLA degradation from mixtures with polyethylene terephthalate (PET) and polymer blends are presented. For the first time, a cascade recycling reaction of a PLA/polycaprolactone (PCL) blend is tested with a zinc-based bisguanidine catalyst, whereby PLA is degraded selectively at first and subsequent modification of the reaction conditions leads to efficient degradation of the remaining PCL. The highly active, universally applicable benign zinc catalyst allows the implementation of a circular plastics economy and thus the reduction of plastic pollution in the environment., (© 2024 The Authors. ChemSusChem published by Wiley-VCH GmbH.)

Cobalt complexes exhibit versatile reactivity with nitric oxide (NO), enabling their utilization in applications ranging from homogeneous catalysis to NO-based modulation of biological processes. However, the coordination geometry around the cobalt center is complex, the therapeutic window of NO is narrow, and controlled NO delivery is difficult. To better understand the complexation of cobalt with NO, we prepared four cobalt nitrato complexes and present a structure-property relationship for ultrasound-triggerable NO release. We hypothesized that modulation of the coordination geometry by ligand-modification would improve responsiveness to mechanical stimuli, like ultrasound. To enable eventual therapeutic testing, we here first demonstrate the in vitro tolerability of [Co(ethylenediamine) 2 (NO)(NO 3 )](NO 3 ) in A431 epidermoid carcinoma cells and J774A.1 murine macrophages, and we subsequently show successful encapsulation of the complex in poly(butyl cyanoacrylate) microbubbles. These hybrid Co-NO-containing microbubbles may in the future aid in ultrasound imaging-guided treatment of NO-responsive vascular pathologies., (© 2024 The Author(s). ChemMedChem published by Wiley-VCH GmbH.)

In a previous study, we showed that the properties and the ability as an entatic state model of copper guanidine quinoline complexes are significantly influenced by a methyl or methyl ester substituent in the 2-position. To prove the importance of the 2-position of the substituent, two novel guanidine quinoline ligands with a methyl or methyl ester substituent in the 4-position and the corresponding copper complexes were synthesized and characterized in this study. The influence of the substituent position on the copper complexes was investigated with various experimental and theoretical methods. The molecular structures of the copper complexes were examined in the solid state by single-crystal X-ray diffraction (SCXRD) and by density functional theory (DFT) calculations indicating a strong dependency on the substituent position compared to the systems substituted in the 2-position from the previous study. Further, the significantly different influence on the donor properties in dependency on the substituent position was analyzed with natural bond orbital (NBO) calculations. By the determination of the redox potentials, the impact on the electrochemical stabilization was examined. With regard to further previously analyzed guanidine quinoline copper complexes, the electrochemical stabilization was correlated with the charge-transfer energies calculated by NBO analysis and ground state energies, revealing the substituent influence and enabling a comparatively easy and accurate possibility for the theoretical calculation of the relative redox potential. Finally, the electron transfer properties were quantified by determining the electron self-exchange rates via the Marcus theory and by theoretical calculation of the reorganization energies via Nelsen's four-point method. The results gave important insights into the dependency between the ability of the copper complexes as entatic state model and the type and position of the substituent.

Tripodal tetradentate N donor ligands stabilise the most active ATRP catalyst systems. Here, we set out to synthesise the new guanidine ligand TMG-4NMe 2 uns-penp, inspired by p -substituted tris(2-pyridylmethyl)amine (TPMA) ligands. The impact of changing pyridine against guanidine donors was examined through solid state and solution experiments and density functional theory (DFT) calculations. In the solid state, the molecular structures of copper complexes based on the ligands TMG-4NMe 2 uns-penp, TMG-uns-penp and TMG 3 tren were discussed concerning the influence of a NMe 2 substituent at the pyridines and the guanidine donors. In solution, the TMG-4NMe 2 uns-penp system was investigated by several methods, including UV/Vis, EPR and NMR spectroscopy indicating similar properties to that of the highly active TPMA NMe2 system. The redox potentials were determined and related to the catalytic activity. Besides the expected trends between these and the ligand structures, there is evidence that guanidine donors in tripodal ligand systems lead to a better deactivation and possibly a faster exchange within the ATRP equilibrium than TPMA systems. Supported by DFT calculations, it derives from an easier cleavable Cu-Br bond of the copper(II) deactivator species. The high activity was stated by a controlled initiator for continuous activator regeneration (ICAR) ATRP of styrene.

Soft polymer nanocapsules and microgels, which can adapt their shape and, at the same time, sequester and release molecular payloads in response to an external trigger, are a challenging complement to vesicular structures like polymersomes. In this work, we report the synthesis of such capsules by photo-cross-linking of coumarin-substituted polyglycidyl ethers, which we prepared by Williamson etherification of epichlorohydrin (ECH) repeating units with 7-hydroxycoumarin in copolymers with tert -butyl glycidyl ether ( t BGE). To control capsule size, we employed the prepolymers in an o/w miniemulsion, where they formed a gel layer at the interface upon irradiation at 365 nm by [2π + 2π] photodimerization of the coumarin groups. Upon irradiation at 254 nm, the reaction could be reversed and the gel wall could be repeatedly disintegrated and rebuilt. We further demonstrated (i) reversible hydrophilization of the gels by hydrolysis of the lactone rings in coumarin dimers as a mechanism to manipulate the permeability of the capsules and (ii) binding functional molecules as amides. Thus, the presented nanogels are remarkably versatile and can be further used as a carrier system., Competing Interests: The authors declare no competing financial interest., (© 2023 The Authors. Published by American Chemical Society.)

A novel dinucleating bis(pyrazolyl)methane ligand was developed for tyrosinase model systems. After ligand synthesis, the corresponding Cu(I) complex was synthesized and upon oxygenation, formation of a µ-η 2 :η 2 peroxido complex could be observed and monitored using UV/Vis-spectroscopy. Due to the high stability of this species even at room temperature, a molecular structure of the complex could be characterized via single-crystal XRD. Additional to its promising stability, the peroxido complex showed catalytic tyrosinase activity which was investigated via UV/Vis-spectroscopy. Products of the catalytic conversion could be isolated and characterized and the ligand could be successfully recycled after catalysis experiments. Furthermore, the peroxido complex was reduced by reductants with different reduction potentials. The characteristics of the electron transfer reactions were investigated with the help of the Marcus relation. The combination of the high stability and catalytic activity of the peroxido complex with the new dinucleating ligand, enables the shift of oxygenation reactions for selected substrates towards green chemistry, which is furthered by the efficient ligand recycling capability.

Invited for this month's cover is the group of Professor Sonja Herres-Pawlis at the RWTH Aachen (Germany). The cover image illustrates the complex yet flexible circular economy of (bio)plastics and the role of a Zn-based catalyst therein. The Research Article itself is available at 10.1002/cssc.202300192., (© 2023 Wiley-VCH GmbH.)

Polylactic acid (PLA) is the bioplastic with the highest market share. However, it is mainly produced from first-generation feedstock and there are various inconsistencies in the literature in terms of its production and recycling processes, carbon footprint, and prices. The aim of this study is to compile and contrast these aspects and investigate second-generation PLA production from technical, economic, and ecological perspectives simultaneously. The comprehensive analyses also show the chances and challenges of originating a PLA supply chain in a specific region. Herein, the German Federal State of North Rhine-Westphalia (NRW) has been chosen as a region of interest. In addition to highlighting the industrial capabilities and synergies, the study quantifies and illustrates the locations of different suitable second-generation feedstocks in the region. However, the identified potentials can be challenged by various obstacles such as the high demand of bioresources, feedstock quality, spatial aspects, and logistics. Furthermore, the substantial price gap between PLA and fossil-based plastics can also discourage the investors to include PLA on their portfolios. Thus, the study also provides recommendations to overcome these obstacles and promote the regional value chains of bioplastics which may serve as prototype for other regions., Competing Interests: The authors declare no conflict of interest., (© 2023 The Authors. Global Challenges published by Wiley‐VCH GmbH.)

In this study, a synthesis route of tri(quinolin-8-yl)amine ( L ), a recent member of the tetradentate tris(2-pyridylmethyl)amine (TPA) ligand family, is reported. With the neutral ligand L bound to an iron(II) center in κ 4 mode, two cis -oriented coordination sites remain vacant. These can be occupied by coligands such as counterions and solvent molecules. How sensitive this equilibrium can be is most evident if both triflate anions and acetonitrile molecules are available. All three combinations─bis(triflato), bis(acetonitrile), and mixed coligand species─could be characterized by single-crystal X-ray diffraction (SCXRD), which is unique so far for this class of ligand. While at room temperature, the three compounds tend to crystallize concomitantly, the equilibrium can be shifted in favor of the bis(acetonitrile) species by lowering the crystallization temperature. Removed from their mother liquor, the latter is very sensitive to evaporation of the residual solvent, which was observed by powder X-ray diffraction (PXRD) and Mössbauer spectroscopy. The solution behavior of the triflate and acetonitrile species was studied in detail using time- and temperature-resolved UV/vis spectroscopy, Mössbauer spectroscopy of frozen solution, NMR spectroscopy, and magnetic susceptibility measurements. The results indicate a bis(acetonitrile) species in acetonitrile showing a temperature-dependent spin-switching behavior between high- and low-spin. In dichloromethane, the results reveal a high-spin bis(triflato) species. In pursuit of understanding the coordination environment equilibria of the [Fe( L )] 2+ complex, a series of compounds with different coligands was prepared and analyzed with SCXRD. The crystal structures indicate that the spin state can be controlled by changing the coordination environment─all of the {N 6 }-coordinated complexes display geometries expected for low-spin species, while any other donor atom in the coligand position induces a shift to the high-spin state. This fundamental study sheds light on the coligand competition of triflate and acetonitrile, and the high number of crystal structures allows further insights into the influence of different coligands on the geometry and spin state of the complexes.

A previously reported non-toxic guanidine-iron catalyst active in the ring opening polymerization (ROP) of polylactide (PLA) under industrially relevant conditions was evaluated for its activity in the alcoholysis and aminolysis of PLA under mild conditions. Kinetic and thermodynamic parameters were determined for the methanolysis of PLA with [FeCl 2 (TMG5NMe 2 asme)] (C1) using 1 H NMR spectroscopy. A comparison with the Zn analog of C1 showed that the metal center has a large impact on the activity for the alcoholysis. Further, the influence of different nucleophiles was tested broadening the scope of products from PLA waste. C1 is the first discrete metal catalyst reported to be active in the selective aminolysis of PLA. Catalyst recycling, scale-up experiments and solvent-free alcoholysis were conducted successfully strengthening the industrial relevance and highlighting aspects of green chemistry. Moreover, the selective depolymerization of PLA in polymer blends was successful. C1 is a promising catalyst for a circular (bio)plastics economy., (© 2022 The Authors. Chemistry - An Asian Journal published by Wiley-VCH GmbH.)

Copper guanidine-quinoline complexes are an important class of bioinorganic complexes that find utilization in electron and atom transfer processes. By substitution of functional groups on the quinoline moiety the electron transfer abilities of these complexes can be tuned. In order to explore the full substitution space by simulations, the accurate theoretical description of the effect of functional groups is essential. In this study, we compare three different methods for the theoretical description of the structures. We use the semi-empirical tight-binding method GFN2-xTB, the density functional TPSSh and the double-hybrid functional B2PLYP. We evaluate the methods on five different complex pairs (Cu(I) and Cu(II) complexes), and compare how well calculated energies can predict the redox potentials. We find even though B2PLYP and TPSSh yield better accordance with the experimental structures. GFN2-xTB performs surprisingly well in the geometry optimization at a fraction of the computational cost. TPSSh offers a good compromise between computational cost and accuracy of the redox potential for real-life complexes., (© 2022 The Authors. Journal of Computational Chemistry published by Wiley Periodicals LLC.)

Bioplastics are one of the answers to environmental pollution and linear material flows. The most promising bioplastic polylactide (PLA) is already replacing conventional plastics in a number of applications. The properties of PLA, however, do not fit for all potential application areas, but they can be altered by the introduction of comonomers. The copolymerization of lactide (LA) with other lactones like ϵ-caprolactone (CL) has been established for several years. Nevertheless, controlling copolymerizations remains a challenge due to the high complexity of the system. Copolymerization of LA with other monomer classes is much less investigated, but has the chance to overcome the limitations in material properties that occur when only lactones are used. The crucial factor for all copolymerizations is the catalyst. It dominates the reaction kinetics and determines the resulting microstructure. In this review, copolymerization catalysts for LA are presented divided into catalysts for the synthesis of lactone block copolymers, lactone random copolymers, and multimechanistically synthesized copolymers. The selected catalysts are highlighted either owing to their industrially applicable polymerization conditions or their non-standard mechanism., (© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Research data management (RDM) is needed to assist experimental advances and data collection in the chemical sciences. Many funders require RDM because experiments are often paid for by taxpayers and the resulting data should be deposited sustainably for posterity. However, paper notebooks are still common in laboratories and research data is often stored in proprietary and/or dead-end file formats without experimental context. Data must mature beyond a mere supplement to a research paper. Electronic lab notebooks (ELN) and laboratory information management systems (LIMS) allow researchers to manage data better and they simplify research and publication. Thus, an agreement is needed on minimum information standards for data handling to support structured approaches to data reporting. As digitalization becomes part of curricular teaching, future generations of digital native chemists will embrace RDM and ELN as an organic part of their research., (© 2022 Wiley-VCH GmbH.)

Soft colloidal macromolecular structures with programmable chemical functionalities, size, and shape are important building blocks for the fabrication of catalyst systems and adaptive biomaterials for tissue engineering. However, the development of the easy upscalable and template-free synthesis methods to obtain such colloids lack in understanding of molecular interactions that occur in the formation mechanisms of polymer colloids. Herein, a computer simulation-driven experimental synthesis approach based on the supramolecular self-assembly followed by polymerization of tailored pyrazole-modified monomers is developed. Simulations for a series of pyrazole-modified monomers with different numbers of pyrazole groups, different length and polarity of spacers between pyrazole groups and the polymerizable group are first performed. Based on simulations, monomers able to undergo π-π stacking and guide the formation of supramolecular bonds between polymer segments are synthesized and these are used in precipitation polymerization to synthesize anisotropic microgels. This study demonstrates that microgel morphologies can be tuned from spherical, raspberry-like to dumbbell-like by the increase of the pyrazole-modified monomer loading, which is concentrated at periphery of growing microgels. Combining experimental and simulation results, this work provides a quantitative and predictive approach for guiding microgel design that can be further extended to a diversity of colloidal systems and soft materials with superior properties., (© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.)

TUCAN is a canonical serialization format that is independent of domain-specific concepts of structure and bonding. The atomic number is the only chemical feature that is used to derive the TUCAN format. Other than that, the format is solely based on the molecular topology. Validation is reported on a manually curated test set of molecules as well as a library of non-chemical graphs. The serialization procedure generates a canonical "tuple-style" output which is bidirectional, allowing the TUCAN string to serve as both identifier and descriptor. Use of the Python NetworkX graph library facilitated a compact and easily extensible implementation., (© 2022. The Author(s).)

Titanium(III) and titanium(IV) formate complexes supported by the sterically encumbering tris(phenolato)amine ligand (H 3 (O 3 N) = tris(4,6-di- tert -butyl-2-hydroxybenzyl)amine) are described. Salt metathesis of the chlorido precursor [(O 3 N)TiCl] (1-Cl) with sodium formate in a 2 : 1 ratio in THF gave a dimer of sodium dititanium triformate units with 12-membered ring [Na{(O 3 N)Ti} 2 (μ-OCHO-η O :η O ') 3 ] 2 (3-Na) when crystallized from acetonitrile. Complex 3-Na was also prepared by reacting the previously reported terminal formate complex [(O 3 N)Ti(OCHO)] (2) with excess sodium formate. Salt metathesis of 1-Cl with potassium formate gave a tetratitanium cluster of the composition [K 3 {(O 3 N)Ti} 4 (OCHO) 7 ] (3-K) which can be also obtained by treating 2 with potassium formate. In 3-K both Ti and K centers are six-coordinate. The titanium(III) complexes [(O 3 N)Ti(L)] (4-L, L = THF, THP, Et 2 O) and solvent free dimeric [(O 3 N)Ti] 2 (5) were synthesized by reduction of 1-Cl with sodium sand or magnesium in THF, THP, Et 2 O, and n -pentane, respectively. The tert -butyl formate adduct of titanium(III)-[(O 3 N)Ti( t BuOCHO)] (6) was isolated by reacting 4-L or 5 with tert -butyl formate. Complex 6 is thermolabile and slowly decomposed in solution to produce a formate-bridged mixed-valence titanium(III)/titanium(IV) complex [{(O 3 N)Ti} 2 (μ-OCHO-η O :η O ')] (7) which further decomposed to a mixture containing 2, [(O 3 N)Ti(OH)] and [(O 3 N)Ti-O-Ti(O 3 N)]. All new complexes were isolated in moderate to good yields and fully characterized by elemental analysis, 1 H and 13 C NMR spectroscopy, and single crystal X-ray diffraction analysis. For the titanium(III) complexes solution magnetic moments were measured by the Evans method and EPR spectra recorded as toluene glass at 77 K.

Invited for this month's cover is the group of Sonja Herres-Pawlis at RWTH Aachen University. The image shows how the zinc guanidine complexes help a circular economy of bioplastics by mediating the ring-opening polymerization of lactide and the depolymerization of polylactide (PLA). The Research Article itself is available at 10.1002/cssc.202201075., (© 2022 Wiley-VCH GmbH.)

Copper bromide complexes based on a series of substituted guanidine-quinolinyl and -pyridinyl ligands are reported. The ligand systems were chosen based on the large variation with regard to their flexibility in the backbone, different guanidine moieties and influence by electron density donating groups. Relationships between the molecular structures and spectroscopic and electronic properties are described. Beside the expected increase in activity by substituting the 4-position (NMe 2 vs . H), we showed that a higher flexibility, such as TMG vs . DMEG moiety, leads to a better stabilsiation of the copper(II) complex. Due to the correlation of the potentials and K ATRP values, the catalyst based on the ligand TMGm4NMe 2 py is the most active copper complex for ATRP with a bidentate ligand system. The combination of the strong donating abilities of dimethylamine pyridinyl, the donor properties of the TMG substituent, and the improved flexibility due to the methylene bridging unit leads to high activity. With all NMe 2 -substituted systems standard ATRP experiments were conducted and with more active NMe 2 -substituted pyridinyl systems, ICAR ATRP experiments of styrene were conducted. Low dispersities and ideal molar masses have been achieved.

Copper guanidine quinolinyl complexes act as good entatic state models due to their distorted structures leading to a high similarity between Cu(i) and Cu(ii) complexes. For a better understanding of the entatic state principle regarding electron transfer a series of guanidine quinolinyl ligands with different substituents in the 2- and 4-position were synthesized to examine the influence on the electron transfer properties of the corresponding copper complexes. Substituents with different steric or electronic influences were chosen. The effects on the properties of the copper complexes were studied applying different experimental and theoretical methods. The molecular structures of the bis(chelate) copper complexes were examined in the solid state by single-crystal X-ray diffraction and in solution by X-ray absorption spectroscopy and density functional theory (DFT) calculations revealing a significant impact of the substituents on the complex structures. For a better insight natural bond orbital (NBO) calculations of the ligands and copper complexes were performed. The electron transfer was analysed by the determination of the electron self-exchange rates following Marcus theory. The obtained results were correlated with the results of the structural analysis of the complexes and of the NBO calculations. Nelsen's four-point method calculations give a deeper understanding of the thermodynamic properties of the electron transfer. These studies reveal a significant impact of the substituents on the properties of the copper complexes., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Our previously published non-toxic guanidine carboxy Zn catalysts, suitable for lactide ring opening polymerisation (ROP) under industrially preferred melt conditions, have been tested towards the alcoholysis of renewable polyesters. A structure-reactivity relationship has been found for the methanolysis of PLA in anhydrous THF, dependent on the substituents introduced at the ligand backbone. Using the unsubstituted "TMGasme" catalyst C2, a polyester conversion of 41 % was reached after 5 h at 60 °C. Introducing an electron density donating -NMe 2 group at the ligand (C3) caused and increase in catalyst activity, resulting in a PLA conversion of 72 %. Hence, C3 was further tested, stressing the industrial applicability of PLA chemical recycling. Catalyst recycling, process scale up as well as solvent free alcoholysis, with full degradation in the PLA melt after 1 h, were demonstrated, allowing for the implementation of a circular (bio)plastics economy promoted by these catalysts., (© 2022 The Authors. ChemPlusChem published by Wiley-VCH GmbH.)

One catalyst, two reaction set-ups, three monomers and unlimited macromolecular microstructural designs: The iron guanidine complex [FeCl 2 (TMG5NMe 2 asme)] (1) polymerizes lactide faster than the industrially used Sn(Oct) 2 and shows high activity towards glycolide and ϵ-caprolactone. Its distinguished features enable the synthesis of both block and random-like copolymers in the melt by a simple change of the polymerization set-up. Sequential addition of monomers yields highly ordered block copolymers including the symmetrical PLA-b-PGA-b-PCL-b-PGA-b-PLA pentablock copolymers, while polymerizations of monomer mixtures feature enhanced transesterifications and pave the way to di- and terpolymers with highly dispersed repeating unit distributions. A robust catalyst active under industrially applicable conditions and producing copolymers with desired microstructures is a major step towards biocompatible polymers with tailor-made properties as alternatives for traditional plastics on the way towards a sustainable, circular material flow., (© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

Nine new complexes based on thioether appended iminophenolate (ONS) ligands have been prepared and fully characterized in solution by NMR spectroscopy. Solid-state structures were also obtained for seven complexes. In solution, all complexes were monomeric. The complexes were highly active for the polymerization of purified rac -lactide ([M] : [Zn] : [BnOH] = 10 000 : 1 : 30 at 180 °C) reaching TOF values up to 250 000 h -1 . The kinetics of the polymerization have been probed by in situ Raman spectroscopy. The rate of reaction was dramatically reduced using technical grade rac -lactide with increased initiator loading. To move towards a circular economy, it is vital that catalysts are developed to facilitate chemical recycling of commodity and emerging polymeric materials. In this vein, the complexes have been assessed for their ability to break down poly(lactic acid) and poly(ethylene terephthalate). The results from both the polymerization and degradation reactions are discussed in terms of ligand functionality., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

The tyrosinase-like activity of hybrid guanidine-stabilized bis(μ-oxido) dicopper(III) complexes [Cu 2 (μ-O) 2 (L) 2 ](X) 2 (L = 2-{2-((Diethylamino)methyl)phenyl}-1,1,3,3-tetramethylguanidine (TMGbenzNEt 2 , L2) and 2-{2-((Di-isopropylamino)methyl)phenyl}-1,1,3,3-tetramethylguanidine (TMGbenzNiPr 2 , L3); X = PF 6 - , BF 4 - , CF 3 SO 3 - ) is described. New aromatic hybrid guanidine amine ligands were developed with varying amine donor function. Their copper(I) complexes were analyzed towards their ability to activate dioxygen in the presence of different weakly coordinating anions. The resulting bis(μ-oxido) species were characterized at low temperatures by UV/Vis and resonance Raman spectroscopy, cryo-ESI mass spectrometry and density functional theory calculations. Small structural changes in the ligand sphere were found to influence the characteristic ligand-to-metal charge transfer (LMCT) features of the bis(μ-oxido) species, correlating a redshift in the UV/Vis spectrum with weaker N-donor function of the ligand. DFT calculations elucidated the influence of the steric and electronic properties of the bis(μ-oxido) species leading to a higher twist of the Cu 2 O 2 plane against the CuN 2 plane and a stretching of the Cu 2 O 2 core. Despite their moderate stability at -100 °C, the bis(μ-oxido) complexes exhibited a remarkable activity in catalytic oxygenation reactions of polycyclic aromatic alcohols. Further the selectivity of the catalyst in the hydroxylation reactions of challenging phenolic substrates is not changed despite an increasing shield of the reactive bis(μ-oxido) core. The generated quinones were found to form exclusively bent phenazines, providing a promising strategy to access tailored phenazine derivatives., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Copolymers are the answer to property limitations of homopolymers. In order to use the full variety of monomers available, catalysts active in more than one polymerization mechanism are currently investigated. Iron guanidine catalysts have shown to be extraordinarily active in ROP of lactide and herein prove their versatility by also promoting ATRP of styrene. The presented iron complex is the first polymerizing lactide and styrene simultaneously to a defined block copolymer in a convenient one-pot synthesis. Both mechanisms work hand in hand with ROP using the dominantly present Fe II species on the dormant side of the ATRP equilibrium. This orthogonal copolymerization by a benign iron catalyst opens up new pathways to biocompatible polymerization procedures broadening the scope of ATRP applications., (© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

Green toxicology is a novel approach increasingly applied for the development of materials and chemicals that are more benign to the environment and human health than their conventional counterparts. It includes predictive eco-toxicological assessments of chemicals during the early developmental process to exclude adverse effects. In the present study, two guanidine zinc catalysts for the ring-opening polymerization of lactide were investigated using eco-toxicological tools. Namely, the fish embryo toxicity assay for teratogenic effects, the ER (α) CALUX assay for endocrine activity and the Ames fluctuation assay for mutagenic potential were applied. Both complexes showed no endocrine activity, mutagenicity or acute aquatic toxicity, however a delayed hatch could be observed, therefore suggesting potential effects on a molecular level. This proof-of-concept study aims to assess the toxicity of guanidine zinc catalysts and is a first step towards the incorporation of toxicological assessments into chemical developmental processes to achieve a sustainable and safe production of catalysts., (Copyright © 2021 Elsevier B.V. All rights reserved.)