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Wastewater treatment plants (WWTPs) receive a wide variety of contaminants that cannot be eliminated or completely removed with current conventional methods. In this sense, the development and use of advanced technologies is a challenge in countries where wastewater sanitation is hardly a guarantee. However, the reuse of treated urban wastewater can function as an alternative to mitigate water pressure and, at the same time, guarantees water quality for potential reuse in agriculture, in the irrigation of landscape or urban green areas, but especially for aquifer recharge. Therefore, this chapter is focused on reviewing the current state of WWTPs in Mexico and the potential reuse of treated water.