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1. Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Author

Eigentler, Andrea, Handle, Florian, Schanung, Silvia, Degen, Antonia, Hackl, Hubert, Erb, Holger H. H., Fotakis, Georgios, Hoefer, Julia, Ploner, Christian, Jöhrer, Karin, Heidegger, Isabel, Pircher, Andreas, Klotz, Werner, Herold, Manfred, Schäfer, Georg, Culig, Zoran, and Puhr, Martin

Published
2024
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2. Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop

Author

Andrade, Luis E.C., Klotz, Werner, Herold, Manfred, Musset, Lucile, Damoiseaux, Jan, Infantino, Maria, Carballo, Orlando G., Choi, May, von Mühlen, Carlos A., Garcia-De La Torre, Ignacio, Satoh, Minoru, Francescantonio, Paulo L.C., Mimori, Tsuneyo, Conrad, Karsten, de Melo Cruvinel, Wilson, Chan, Edward K.L., and Fritzler, Marvin J.

Published
2024
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4. How to report the antinuclear antibodies (anti-cell antibodies) test on HEp-2 cells: guidelines from the ICAP initiative

Author

von Mühlen, Carlos Alberto, Garcia-De La Torre, Ignacio, Infantino, Maria, Damoiseaux, Jan, Andrade, Luis E. C., Carballo, Orlando Gabriel, Conrad, Karsten, Francescantonio, Paulo Luiz Carvalho, Fritzler, Marvin J., Herold, Manfred, Klotz, Werner, de Melo Cruvinel, Wilson, Mimori, Tsuneyo, Satoh, Minoru, Musset, Lucile, and Chan, Edward K. L.

Published
2021
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5. Prediction of ineffectiveness of biological drugs using machine learning and explainable AI methods: data from the Austrian Biological Registry BioReg

Author

Ukalovic, Dubravka, primary, Leeb, Burkhard F., additional, Rintelen, Bernhard, additional, Eichbauer-Sturm, Gabriela, additional, Spellitz, Peter, additional, Puchner, Rudolf, additional, Herold, Manfred, additional, Stetter, Miriam, additional, Ferincz, Vera, additional, Resch-Passini, Johannes, additional, Zwerina, Jochen, additional, Zimmermann-Rittereiser, Marcus, additional, and Fritsch-Stork, Ruth, additional

Published
2024
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6. Overcoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics

Author

Nairz, Manfred, Bellmann-Weiler, Rosa, Ladstätter, Miriam, Schüllner, Falko, Zimmermann, Martina, Koller, Anna-Maria, Blunder, Silvia, Naschberger, Helene, Klotz, Werner, Herold, Manfred, Kerndler, Sylvia, Jeske, Martina, Haschka, David, Petzer, Verena, Schroll, Andrea, Sonnweber, Thomas, Tancevski, Ivan, Fritsche, Gernot, de Araujo, Mariana E. G., Stasyk, Taras, Huber, Lukas A., Griesmacher, Andrea, Theurl, Igor, and Weiss, Günter

Published
2021
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7. M

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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8. R

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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9. I

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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10. H

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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11. G

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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12. F

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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13. E

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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14. D

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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15. B

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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16. C

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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17. V

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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18. T

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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19. N

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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20. A

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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21. S

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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22. P

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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23. O

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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24. L

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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25. J

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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26. Rekomendacje EFLM, EASI oraz ICAP: Detekcja przeciwciał przeciwjądrowych Publikacja EFLM.

Author

Bonroy, Carolien, Vercammen, Martine, Fierz, Walter, Andrade, Luis E. C., Van Hoovels, Lieve, Infantino, Maria, Fritzler, Marvin J., Bogdanos, Dimitrios, Kozmar, Ana, Nespola, Benoit, Broeders, Sylvia, Patel, Dina, Herold, Manfred, Zheng, Bing, Chan, Eric Y. T., Uibo, Raivo, Haapala, Anna-Maija, Musset, Lucile, Sack, Ulrich, and Nagy, Gabor

Subjects
COMPUTER-aided diagnosis, ANTINUCLEAR factors, CLINICAL chemistry, EUROPEAN integration, CHEMICAL laboratories
Abstract

Copyright of Journal of Laboratory Diagnostics / Diagnostyka Laboratoryjna is the property of Index Copernicus International and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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27. Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Author

Eigentler, Andrea, primary, Handle, Florian, additional, Schanung, Silvia, additional, Degen, Antonia, additional, Hackl, Hubert, additional, Erb, Holger H. H., additional, Fotakis, Georgios, additional, Hoefer, Julia, additional, Ploner, Christian, additional, Jöhrer, Karin, additional, Heidegger, Isabel, additional, Pircher, Andreas, additional, Klotz, Werner, additional, Herold, Manfred, additional, Schäfer, Georg, additional, Culig, Zoran, additional, and Puhr, Martin, additional

Published
2023
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29. Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey

Author

Van Hoovels, Lieve, Broeders, Sylvia, Chan, Edward K. L., Andrade, Luis, de Melo Cruvinel, Wilson, Damoiseaux, Jan, Viander, Markku, Herold, Manfred, Coucke, Wim, Heijnen, Ingmar, Bogdanos, Dimitrios, Calvo-Alén, Jaime, Eriksson, Catharina, Kozmar, Ana, Kuhi, Liisa, Bonroy, Carolien, Lauwerys, Bernard, Schouwers, Sofie, Lutteri, Laurence, Vercammen, Martine, Mayer, Miroslav, Patel, Dina, Egner, William, Puolakka, Kari, Tesija-Kuna, Andrea, Shoenfeld, Yehuda, de Sousa, Maria José Rego, Hoyos, Marcos Lopez, Radice, Antonella, and Bossuyt, Xavier

Published
2020
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30. K

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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34. Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP

Author

Bonroy, Carolien, primary, Vercammen, Martine, additional, Fierz, Walter, additional, Andrade, Luis E.C., additional, Van Hoovels, Lieve, additional, Infantino, Maria, additional, Fritzler, Marvin J., additional, Bogdanos, Dimitrios, additional, Kozmar, Ana, additional, Nespola, Benoit, additional, Broeders, Sylvia, additional, Patel, Dina, additional, Herold, Manfred, additional, Zheng, Bing, additional, Chan, Eric Y.T., additional, Uibo, Raivo, additional, Haapala, Anna-Maija, additional, Musset, Lucile, additional, Sack, Ulrich, additional, Nagy, Gabor, additional, Sundic, Tatjana, additional, Fischer, Katarzyna, additional, Rego de Sousa, Maria-José, additional, Vargas, Maria Luisa, additional, Eriksson, Catharina, additional, Heijnen, Ingmar, additional, García-De La Torre, Ignacio, additional, Carballo, Orlando Gabriel, additional, Satoh, Minoru, additional, Kim, Kyeong-Hee, additional, Chan, Edward K.L., additional, Damoiseaux, Jan, additional, Lopez-Hoyos, Marcos, additional, and Bossuyt, Xavier, additional

Published
2023
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35. Detection of antinuclear antibodies : recommendations from EFLM, EASI and ICAP

Author

Bonroy, Carolien, Vercammen, Martine, Fierz, Walter, Andrade, Luis E.C., Van Hoovels, Lieve, Infantino, Maria, Fritzler, Marvin J., Bogdanos, Dimitrios, Kozmar, Ana, Nespola, Benoit, Broeders, Sylvia, Patel, Dina, Herold, Manfred, Zheng, Bing, Chan, Eric Y.T., Uibo, Raivo, Haapala, Anna-Maija, Musset, Lucile, Sack, Ulrich, Nagy, Gabor, Sundic, Tatjana, Fischer, Katarzyna, Rego De Sousa, Maria-José, Vargas, Maria Luisa, Eriksson, Catharina, Heijnen, Ingmar, García-De La Torre, Ignacio, Carballo, Orlando Gabriel, Satoh, Minoru, Kim, Kyeong-Hee, Chan, Edward K.L., Damoiseaux, Jan, Lopez-Hoyos, Marcos, Bossuyt, Xavier, Bonroy, Carolien, Vercammen, Martine, Fierz, Walter, Andrade, Luis E.C., Van Hoovels, Lieve, Infantino, Maria, Fritzler, Marvin J., Bogdanos, Dimitrios, Kozmar, Ana, Nespola, Benoit, Broeders, Sylvia, Patel, Dina, Herold, Manfred, Zheng, Bing, Chan, Eric Y.T., Uibo, Raivo, Haapala, Anna-Maija, Musset, Lucile, Sack, Ulrich, Nagy, Gabor, Sundic, Tatjana, Fischer, Katarzyna, Rego De Sousa, Maria-José, Vargas, Maria Luisa, Eriksson, Catharina, Heijnen, Ingmar, García-De La Torre, Ignacio, Carballo, Orlando Gabriel, Satoh, Minoru, Kim, Kyeong-Hee, Chan, Edward K.L., Damoiseaux, Jan, Lopez-Hoyos, Marcos, and Bossuyt, Xavier

Abstract

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing”; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP). Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations. Conclusions: These recommendations are an important step to achieve high quality ANA testing.

Published
2023
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36. W

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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37. U

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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38. Q

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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41. Z

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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42. X

Author

Rovenský, Jozef, Payer, Juraj, Herold, Manfred, Rovenský, Jozef, editor, Payer, Juraj, editor, and Herold, Manfred, editor

Published
2016
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44. Repository of intra- and inter-run variations of quantitative autoantibody assays: a European multicenter study

Author

Dragon-Durey, Marie-Agnès, primary, Bizzaro, Nicola, additional, Senant, Marie, additional, Andreeva, Hristina, additional, Bogdanos, Dimitrios P., additional, Bonroy, Carolien, additional, Bossuyt, Xavier, additional, Eriksson, Catharina, additional, Fabien, Nicole, additional, Heijnen, Ingmar, additional, Herold, Manfred, additional, Musset, Lucile, additional, Kuhi, Liisa, additional, Lopez-Hoyos, Marcos, additional, Berki, Tímea, additional, Roozendaal, Caroline, additional, Sack, Ulrich, additional, Sundic, Tatjana, additional, Taylor, Lorna, additional, Kuna, Andrea Tesija, additional, and Damoiseaux, Jan, additional

Published
2022
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45. Die Bedeutung der systemischen Glukokortikoid Begleitmedikation auf die stromale Glukokortikoidrezeptor-Aktivität und Auswirkungen auf das Prostatatumor Wachstum

Author

Puhr, Martin, Hackl, Hubert, Ploner, Christian, Klotz, Werner, Herold, Manfred, Jöhrer-Deym, Karin, Sampson, Natalie, and Klocker, Helmut

Subjects
ddc: 610, Medicine and health
Abstract

Fragestellung: Ein schwerwiegendes Problem in der Behandlung des fortgeschrittenen Prostatakarzinoms ist das Auftreten von Resistenzen gegenüber den verwendeten Medikamenten im Zuge der Anti-Androgen und Chemotherapie. Obwohl der Androgenrezeptor (AR) das Haupttarget der medikamentösen Prostatakrebstherapie [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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46. Repository of intra-and inter-run variations of quantitative autoantibody assays: A European multicenter study

Author

Dragon-Durey, Marie-Agnès, Bizzaro, Nicola, Senant, Marie, Andreeva, Hristina, Bogdanos, Dimitrios P., Bonroy, Carolien, Bossuyt, Xavier, Eriksson, Catharina, Fabien, Nicole, Heijnen, Ingmar, Herold, Manfred, Musset, Lucile, Kuhi, Liisa, Lopez-Hoyos, Marcos, Berki, Tímea, Roozendaal, Caroline, Sack, Ulrich, Sundic, Tatjana, Taylor, Lorna, Kuna, Andrea Tesija, Damoiseaux, Jan, Dragon-Durey, Marie-Agnès, Bizzaro, Nicola, Senant, Marie, Andreeva, Hristina, Bogdanos, Dimitrios P., Bonroy, Carolien, Bossuyt, Xavier, Eriksson, Catharina, Fabien, Nicole, Heijnen, Ingmar, Herold, Manfred, Musset, Lucile, Kuhi, Liisa, Lopez-Hoyos, Marcos, Berki, Tímea, Roozendaal, Caroline, Sack, Ulrich, Sundic, Tatjana, Taylor, Lorna, Kuna, Andrea Tesija, and Damoiseaux, Jan

Abstract

No reference data are available on repositories to measure precision of autoantibody assays. The scope of this study was to document inter-and intra-run variations of quantitative autoantibody assays based on a real-world large international data set. Members of the European Autoimmunity Standardisation Initiative (EASI) group collected the data of intra-and inter-run variability obtained with assays quantifying 15 different autoantibodies in voluntary participating laboratories from their country. We analyzed the impact on the assay performances of the type of immunoassay, the number of measurements used to calculate the coefficient of variation (CVs), the nature and the autoantibody level of the internal quality control (IQC). Data were obtained from 64 laboratories from 15 European countries between February and October 2021. We analyzed 686 and 1,331 values of intra-and inter-run CVs, respectively. Both CVs were significantly dependent on: The method of immunoassay, the level of IQC with higher imprecision observed when the antibody levels were lower than 2-fold the threshold for positivity, and the nature of the IQC with commercial IQCs having lower CVs than patients-derived IQCs. Our analyses also show that the type of autoantibody has low impact on the assay' performances and that 15 measurements are sufficient to establish reliable intra-and inter-run variations. This study provides for the first time an international repository yielding values of intra-and inter-run variation for quantitative autoantibody assays. These data could be useful for ISO 15189 accreditation requirements and will allow clinical diagnostic laboratories to assure quality of patient results.

Published
2022
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48. The International Consensus on ANA Patterns (ICAP) in 2021—The 6th Workshop and Current Perspectives

Author

Chan, Edward K L, primary, von Mühlen, Carlos A, additional, Fritzler, Marvin J, additional, Damoiseaux, Jan, additional, Infantino, Maria, additional, Klotz, Werner, additional, Satoh, Minoru, additional, Musset, Lucile, additional, García-De La Torre, Ignacio, additional, Carballo, Orlando Gabriel, additional, Herold, Manfred, additional, de Melo Cruvinel, Wilson, additional, Mimori, Tsuneyo, additional, Conrad, Karsten, additional, and Andrade, Luis E C, additional

Published
2022
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49. The impact of the COVID-19 pandemic on autoimmune diagnostics in Europe: A lesson to be learned

Author

Nagy, Eszter, primary, Infantino, Maria, additional, Bizzaro, Nicola, additional, Andreeva, Hristina, additional, Bontkes, Hetty J., additional, Bossuyt, Xavier, additional, Fabien, Nicole, additional, Fischer, Katarzyna, additional, Heijnen, Ingmar A.F.M., additional, Herold, Manfred, additional, Kozmar, Ana, additional, Kuhi, Liisa, additional, López-Hoyos, Marcos, additional, Pullerits, Rille, additional, Sousa, Maria José Rego, additional, Tsirogianni, Alexandra, additional, and Damoiseaux, Jan, additional

Published
2021
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