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6. Hip fractures re-operation compared with death at two year in elderly patients: lowest risk of revision with dual mobility total hip arthroplasty than with bipolar hemiarthroplasty or internal fixation of Garden I and II

Author

Valcarenghi, Jérome, Martinov, Sagi, Chahidi, Esfandiar, Jennart, Harold, Bui Quoc, Emily, Dimanche, Marie Charlotte, Hupez, Alexandre, Bhogal, Harkirat, Hafez, Karim, Callewier, Antoine, Bath, Olivier, and Hernigou, Jacques

Published
2022
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8. Survivorship and complications of cementless compared to cemented posterior-stabilized total knee arthroplasties: A systematic review and meta-analysis

Author

Chahidi Esfandiar, Martinov Sagi, Simion Filip, Mercier Camille, Sabot Liam, Kyriakydis Theofylaktos, Callewier Antoine, and Hernigou Jacques

Subjects
cementless total knee arthroplasty, posterior stabilized, survivorship, Orthopedic surgery, RD701-811
Abstract

Purpose: Controversy exists on the best fixation for total knee arthroplasty (TKA). Non-cemented fixation has been theorized to improve patient outcomes and longevity of implantation but no study has focused on comparison between cemented or cementless posterior-stabilized implants despite being the most commonly or second most frequently utilized implant in most total knee replacement registries. Methods: Inclusion criteria with observational and interventional papers, and review articles that focused on patients with cementless and cemented PS TKAs were used to analyze outcomes such as implant survivorship, complication, or revision rates. Using a combination of keywords, a systematic search was performed on Medline (PubMed), Embase, and Cochrane Library for Meta-Analysis. Results: When using the specified criteria, only 8 studies were selected for full-text analysis and meta-analysis after eliminating screening duplicates, titles, and abstracts without full-text access. These eight studies contain 1652 patients, 693 in the non-cemented Group, and 959 in the cemented total knee prosthesis Group. The meta-analysis revealed the advantage of cementless fixation over cemented fixation in implant survivorship, with 0.6% and 2.6% of aseptic loosening in each Group. The cumulative survival at 12 years was 97.4% for the cementless Group and 89.2% for the cemented Group. The subgroup with a stem showed a positive outcome for cementless fixation over cemented fixation regarding implant survivorship. No differences between the cemented and cementless TKAs were observed in patient-reported outcomes, revision rates, or radiolucent line development. Conclusion: We observed comparable rates for cemented and cementless posterior-stabilized TKAs over a medium-term follow-up period.

Published
2024
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19. Mesenchymal Stem Cell Therapy for Bone Repair of Human Hip Osteonecrosis with Bilateral Match-Control Evaluation: Impact of Tissue Source, Cell Count, Disease Stage, and Volume Size on 908 Hips.

Author

Hernigou, Philippe, Homma, Yasuhiro, Hernigou, Jacques, Flouzat Lachaniette, Charles Henri, Rouard, Helène, and Verrier, Sophie

Subjects
MESENCHYMAL stem cells, ARTIFICIAL hip joints, STEM cell treatment, OSTEONECROSIS, REPAIRING, BONE cells, DISEASE progression
Abstract

We investigated the impact of mesenchymal stem cell (MSC) therapy on treating bilateral human hip osteonecrosis, analyzing 908 cases. This study assesses factors such as tissue source and cell count, comparing core decompression with various cell therapies. This research emphasizes bone repair according to pre-treatment conditions and the specificities of cell therapy in osteonecrosis repair, indicating a potential for improved bone repair strategies in hips without femoral head collapse. This study utilized a single-center retrospective analysis to investigate the efficacy of cellular approaches in the bone repair of osteonecrosis. It examined the impact on bone repair of tissue source (autologous bone marrow concentrate, allogeneic expanded, autologous expanded), cell quantity (from none in core decompression alone to millions in cell therapy), and osteonecrosis stage and volume. Excluding hips with femoral head collapse, it focused on patients who had bilateral hip osteonecrosis, both pre-operative and post-operative MRIs, and a follow-up of over five years. The analysis divided these patients into seven groups based on match control treatment variations in bilateral hip osteonecrosis, primarily investigating the outcomes between core decompression, washing effect, and different tissue sources of MSCs. Younger patients (<30 years) demonstrated significantly better repair volumes, particularly in stage II lesions, than older counterparts. Additionally, bone repair volume increased with the number of implanted MSCs up to 1,000,000, beyond which no additional benefits were observed. No significant difference was observed in repair outcomes between different sources of MSCs (BMAC, allogenic, or expanded cells). The study also highlighted that a 'washing effect' was beneficial, particularly for larger-volume osteonecrosis when combined with core decompression. Partial bone repair was the more frequent event observed, while total bone repair of osteonecrosis was rare. The volume and stage of osteonecrosis, alongside the number of injected cells, significantly affected treatment outcomes. In summary, this study provides comprehensive insights into the effectiveness and variables influencing the use of mesenchymal stem cells in treating human hip osteonecrosis. It emphasizes the potential of cell therapy while acknowledging the complexity and variability of results based on factors such as age, cell count, and disease stage. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Vitamin C prevention of complex regional pain syndrome after foot and ankle surgery: a prospective randomized study of three hundred and twenty nine patients

Author

Hernigou, Jacques, primary, Labadens, Adeline, additional, Ghistelinck, Barbara, additional, Bui Quoc, Emilie, additional, Maes, Renaud, additional, Bhogal, Harkirat, additional, Callewier, Antoine, additional, Bath, Olivier, additional, Chahidi, Esfandiar, additional, and Safar, Adonis, additional

Published
2021
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37. Role of matrix‐associated autologous chondrocyte implantation with spheroids in the treatment of large chondral defects in the knee: A systematic review

Author

Zorgeenheid Orthopaedie Medisch, Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, Vonk, Lucienne Angela, Roël, Giulietta, Hernigou, Jacques, Kaps, Christian, Hernigou, Philippe, Zorgeenheid Orthopaedie Medisch, Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, Vonk, Lucienne Angela, Roël, Giulietta, Hernigou, Jacques, Kaps, Christian, and Hernigou, Philippe

Published
2021

38. Role of scaffolds, subchondral, intra-articular injections of fresh autologous bone marrow concentrate regenerative cells in treating human knee cartilage lesions: Different approaches and different results

Author

Hernigou, Jacques, Vertongen, Pascale, Rasschaert, Joanne, Hernigou, Philippe, Hernigou, Jacques, Vertongen, Pascale, Rasschaert, Joanne, and Hernigou, Philippe

Abstract

The value of bone marrow aspirate concentrates for treatment of human knee cartilage lesions is unclear. Most of the studies were performed with intra-articular injections. However, subchondral bone plays an important role in the progression of osteoarthritis. We investigated by a literature review whether joint, subchondral bone, or/and scaffolds implantation of fresh autologous bone marrow aspirate concentrated (BMAC) containing mesenchymal stem cells (MSCs) would improve osteoarthritis (OA). There is in vivo evidence that suggests that all these different approaches (intra-articular injections, subchondral implantation, scaffolds loaded with BMAC) can improve the patient. This review analyzes the evidence for each different approach to treat OA. We found that the use of intra-articular injections resulted in a significant relief of pain symptoms in the short term and was maintained in 12 months. However, the clinical trials indicate that the application of autologous bone marrow concentrates in combination with scaffolds or in injection in the subchondral bone was superior to intra-articular injection for long-term results. The tendency of MSCs to differentiate into fibrocartilage affecting the outcome was a common issue faced by all the studies when biopsies were performed, except for scaffolds implantation in which some hyaline cartilage was found. The review suggests also that both implantation of subchondral BMAC and scaffolds loaded with BMAC could reduce the need for further surgery., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2021

39. Psychometric properties of the Cumulated Ambulation Score French translation

Author

Chahidi Esfandiar, Heurion Lindsey, Ledoux Amandine, Hernigou Jacques, Thüngen Thibaut, Luisetto Matteo, Valcarenghi Jérôme, Jennart Harold, and Kristensen Morten Tange

Subjects
Male, medicine.medical_specialty, Injury control, Psychometrics, Accident prevention, Poison control, Physical Therapy, Sports Therapy and Rehabilitation, Walking, Disability Evaluation, Medicine, Humans, In patient, Translations, Postoperative Period, Reliability (statistics), Aged, Aged, 80 and over, Hip fracture, Fragility fracture, business.industry, Hip Fractures, Rehabilitation, Reproducibility of Results, medicine.disease, Physical therapy, business
Abstract

Objective: To examine measurement properties (inter-rater reliability, agreement, validity, and responsiveness) of the Cumulated Ambulation Score French translation in patients with hip fracture. Design: Methodological study. Setting: A 20-bed orthopedic unit and 20-bed geriatric unit. Subjects: About 140 consecutive patients with a mean (SD) age of 83 (12) years. Interventions: The English version of the Cumulated Ambulation Score used to evaluate basic mobility was translated into French following international guidelines. Two raters independently assessed all patients on postoperative days one, two, three, and 30 after a hip fracture surgery. Relative and absolute inter-rater reliability and responsiveness (effect size for improvement from postoperative day two to 30) were evaluated. Convergent validity was analyzed by Spearman’s correlation coefficient comparing the Cumulated Ambulation Score with two other measures on postoperative day two and 30. Main measure: Cumulated Ambulation Score. Results: The weighted Kappa value ranged from 0.89 to 1.0. The standard error of measurement and the smallest real difference of the Cumulated Ambulation Score ranged, respectively, from 0.12 to 0.23 and from 0.32 to 0.6 points, while the effect size reached 1.03 (95% CI 0.87–1.26). There was a strong positive correlation comparing the Cumulated Ambulation Score with the French Tinetti Assessment Tool ( r ⩾ 0.83) and the French Mini Motor Test ( r ⩾ 0.79). Conclusions: Our findings indicate that the Cumulated Ambulation Score’s French version is a reliable and valid tool to assess patients’ basic mobility with hip fractures.

Published
2020

40. Psychometric properties of the Cumulated Ambulation Score French translation

Author

Valcarenghi, Jerome, Chahidi, Esfandiar, Morten Tange, Kristensen, Ledoux, Amandine, Jennart, Harold, Luisetto, Matteo, Hernigou, Jacques, and Thüngen, T

Subjects
Elderly patients, Hip Fracture, Orthopédie, Validation score, Fragility Fracture, Basic mobility
Abstract

Objective:To examine measurement properties (inter-rater reliability, agreement, validity, and responsiveness) of the Cumulated Ambulation Score French translation in patients with hip fracture.Design:Methodological study.Setting:A 20-bed orthopedic unit and 20-bed geriatric unit.Subjects:About 140 consecutive patients with a mean (SD) age of 83 (12) years.Interventions:The English version of the Cumulated Ambulation Score used to evaluate basic mobility was translated into French following international guidelines. Two raters independently assessed all patients on postoperative days one, two, three, and 30 after a hip fracture surgery. Relative and absolute inter-rater reliability and responsiveness (effect size for improvement from postoperative day two to 30) were evaluated. Convergent validity was analyzed by Spearman’s correlation coefficient comparing the Cumulated Ambulation Score with two other measures on postoperative day two and 30.Main measure:Cumulated Ambulation Score.Results:The weighted Kappa value ranged from 0.89 to 1.0. The standard error of measurement and the smallest real difference of the Cumulated Ambulation Score ranged, respectively, from 0.12 to 0.23 and from 0.32 to 0.6 points, while the effect size reached 1.03 (95% CI 0.87–1.26). There was a strong positive correlation comparing the Cumulated Ambulation Score with the French Tinetti Assessment Tool (r ⩾ 0.83) and the French Mini Motor Test (r ⩾ 0.79).Conclusions:Our findings indicate that the Cumulated Ambulation Score’s French version is a reliable and valid tool to assess patients’ basic mobility with hip fractures., info:eu-repo/semantics/published

Published
2020

42. Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty

Author

Hernigou Jacques, Callewier Antoine, Sohm Lucile, Kyriakidis Theofylaktos, Bath Olivier, Valcarenghi Jérôme, Decottenier Valérie, and Ledoux Amandine

Subjects
Vitamin, medicine.medical_specialty, Pain, Ascorbic Acid, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Statistical significance, Internal medicine, Medicine, Humans, Orthopedics and Sports Medicine, Prospective Studies, Arthroplasty, Replacement, Knee, 030203 arthritis & rheumatology, 030222 orthopedics, medicine.diagnostic_test, business.industry, Chronic pain, medicine.disease, Complex regional pain syndrome, chemistry, Bone scintigraphy, Relative risk, Cohort, Surgery, business, Complication, Complex Regional Pain Syndromes
Abstract

Complex regional pain syndrome (CRPS) type I, formerly known as reflex sympathetic dystrophy (RSD) or algodystrophy, is a condition with chronic pain condition following a trauma or surgery. The physiopathology of this syndrome remained incompletely known. Due to the lack of effective curative treatment, prevention of this complication is important. Therefore, we evaluated the efficacy of vitamin C in preventing this complication.Between January 2018 and July 2019, we conducted a prospective randomized study on the efficiency of vitamin C (one group with and one without vitamin C) on prevention of CRPS risk in patients operated in our institution with TKA. Patients with a VAS pain score4 performed a three-phase bone scintigraphy. The diagnostic of CRPS was made by using the Budapest criteria associated to a bone scintigraphy. Statistical significance was set at p0.05 RESULTS: One hundred fifty-three patients were included in the vitamin C group, 139 in the control group without vitamin C. For the entire cohort, the prevalence of complex regional pain syndrome was 7.9% (23 of 292). The prevalence of complex regional pain syndrome was 3.9% (six of 153) in the vitamin C group and 12.2% (seventeen of 139) in the control group (p = 0.008). After multivariate regression, vitamin C was found to be an independent preventive factor of CRPS and there was a significant difference between the vitamin C group and the control group (relative risk, 0.27; 95% confidence interval, 0.1-0.8; p = 0.015).Taking 1 g per day of vitamin C during 40 days after a TKA reduces the risk of CRPS.

Published
2020

43. sj-pdf-1-cre-10.1177_0269215520984321 – Supplemental material for Psychometric properties of the Cumulated Ambulation Score French translation

Author

Valcarenghi Jérôme, Chahidi Esfandiar, Kristensen Morten Tange, Ledoux Amandine, Jennart Harold, Luisetto Matteo, Heurion Lindsey, Hernigou Jacques, and Thüngen Thibaut

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-cre-10.1177_0269215520984321 for Psychometric properties of the Cumulated Ambulation Score French translation by Valcarenghi Jérôme, Chahidi Esfandiar, Kristensen Morten Tange, Ledoux Amandine, Jennart Harold, Luisetto Matteo, Heurion Lindsey, Hernigou Jacques and Thüngen Thibaut in Clinical Rehabilitation

Published
2020
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44. Long-term follow-up of the incisional hernia rate after single-incision laparoscopic cholecystectomy: a prospective observational study

Author

Valcarenghi, Jerome, Hernigou, Jacques, Apicella, Giulia, Clegg, Emilie, Rousié, Maxime, Chasse, Emmanuel, Valcarenghi, Jerome, Hernigou, Jacques, Apicella, Giulia, Clegg, Emilie, Rousié, Maxime, and Chasse, Emmanuel

Abstract

Purpose: To evaluate the long-term occurrence rate of incisional hernias following single-incision laparoscopic cholecystectomy (SILC).Background: Since the 90 s, SILC has emerged as a less invasive alternative to standard laparoscopic cholecystectomy in selected patients. But concerns over port-incisional hernias have not been addressed.Methods: Between February 2009 and February 2011, 142 patients referred for gallstones who agreed to undergo SILC were included in a monocenter prospective observational study. All of the procedures were carried out using a single-port access technique. The occurrence rates of incisional hernias were analyzed with the Kaplan-Meier actuarial method. Statistical significance was set at p < .05.Results: A total of 142 patients with gallbladder pathology were included in the study; 138 of them underwent SILC and 4 were converted to standard multiport cholecystectomy. Twelve patients (8%) were found to have developed a port-site incisional hernia (PSH) by physical examination or by imaging. The Kaplan-Meier curve showed that the rate of PSH development was 83% in the first 2 years after surgery. After 2 years, this risk becomes quite low.Conclusions: Our results indicate that the SILC procedure is a safe option for treatment of benign gallbladder diseases for selected patients, albeit with a high incisional hernia rate., info:eu-repo/semantics/published

Published
2020

47. Tobacco and bone fractures: A review of the facts and issues that every orthopaedic surgeon should know

Author

Hernigou, Jacques, Schuind, Frederic, Hernigou, Jacques, and Schuind, Frederic

Abstract

Objectives The aim of this study was to review the impact of smoking tobacco on the musculoskeletal system, and on bone fractures in particular. Methods english-language publications of human and animal studies categorizing subjects into smokers and nonsmokers were sourced from MeDLIne, The cochrane Library, and scopUs. This review specifically focused on the risk, surgical treatment, and prevention of fracture complications in smokers. Results smokers have an increased risk of fracture and experience more complications with delayed bone healing, even if they have already stopped smoking, because some adverse effects persist for a prolonged period. some risks can be reduced during and after surgery by local and general prevention, and smoking cessation is an important factor in lessening this risk. However, if a patient wants to stop smoking at the time of a fracture, the cessation strategies in reducing tobacco use are not easy to implement. The patient should also be warned that using e-cigarettes or other tobaccos does not appear to reduce adverse effects on health. Conclusion The evidence reviewed in this study shows that smoking has a negative effect in terms of the risk and treatment of fractures., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2019

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