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1. Vaccination trends in people with HIV infection participanting in the hospital-based survey of patients infected with HIV, 2006–2021

Author

Hernando, Victoria, Suárez, Lucia, Gutiérrez, Gonzalo, López, Juan Carlos, Navarro-Soler, Roser, Cabello, Alfonso, Sanz, Jesús, Suarez-García, Inés, Fernández, Maria Teresa, Losa, Juan Emilio, Pérez, Jose Luis, Ramos-Ruperto, Luis, Pérez-Elías, Maria Jesús, Aayuni, Wafa Ben Cheikh El, Cuesta, Mar, González, Gustavo, Izquierdo, Ana, Viloria, Luis, López, Irene, Martínez, Eva, Castrillejo, Daniel, Jaume Amengual, Maria Glòria, Belmonte, Maria Antonia, Arraiza, Antonio, de la Torre, Javier, Miqueleiz, Estrella, Marcos, Henar, Ruiz-Algueró, Marta, Villegas, Teresa, Simón, Lorena, and Diaz, Asuncion

Published
2024
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2. Tendencia en la vacunación en personas con infección por VIH participantes en la Encuesta Hospitalaria de pacientes con VIH, 2006-2021

Author

Hernando, Victoria, Suárez, Lucia, Gutiérrez, Gonzalo, López, Juan Carlos, Navarro-Soler, Roser, Cabello, Alfonso, Sanz, Jesús, Suarez-García, Inés, Fernández, Maria Teresa, Losa, Juan Emilio, Pérez, Jose Luis, Ramos-Ruperto, Luis, Pérez-Elías, Maria Jesús, Aayuni, Wafa Ben Cheikh El, Cuesta, Mar, González, Gustavo, Izquierdo, Ana, Viloria, Luis, López, Irene, Martínez, Eva, Castrillejo, Daniel, Jaume Amengual, Maria Glòria, Belmonte, Maria Antonia, Arraiza, Antonio, de la Torre, Javier, Miqueleiz, Estrella, Marcos, Henar, Ruiz-Algueró, Marta, Villegas, Teresa, Simón, Lorena, and Diaz, Asuncion

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2024
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5. Acceptability of Long-Acting Injectable Antiretroviral Treatment for HIV Management: Perspectives of Patients and Physicians in Spain.

Author

Moreno, Cristina, Izquierdo, Rebeca, Alejos, Belén, Hernando, Victoria, Pérez de la Cámara, Santiago, Peraire, Joaquim, Macías, Juan, Bernal, Enrique, Albendín-Iglesias, Helena, Alcaraz, Begoña, Suárez-García, Inés, Moreno, Santiago, and Jarrín, Inma

Subjects
PATIENT compliance, ANTIRETROVIRAL agents, RESEARCH funding, QUESTIONNAIRES, SEX distribution, HIV infections, PHYSICIANS' attitudes, INTERNET, DESCRIPTIVE statistics, ORAL drug administration, INJECTIONS, PSYCHOLOGY of HIV-positive persons, LONGITUDINAL method, SURVEYS, ODDS ratio, RESEARCH, QUALITY of life, PAIN, CONFIDENCE intervals, PATIENTS' attitudes
Abstract

We assessed the prevalence and factors associated with HIV-infected patients' interest in trying long-acting injectable antiretroviral treatment (LAI-ART) along with its expected benefits and concerns, and evaluated physicians' opinions about LAI-ART. This study was set within the multi-center prospective CoRIS cohort, comprising HIV-positive adults, naïve to antiretroviral treatment (ART) at study entry, recruited from 2004 onward in 48 centers in Spain. In June 2022, we conducted a 2-day cross-sectional survey among patients across 34 CoRIS centers and sent an online questionnaire to all physicians prescribing ART in 39 CoRIS centers. Of the 271 patients included, 83.3% [95% confidence interval (CI)]: 78.0 − 87.0%) expressed interest in receiving LAI-ART. This interest was higher among men (adjusted odds ratio: 2.96; 95% CI: 1.4–6.12), those aged <50 years (2.41; 1.23 − 4.73), and individuals inconvenienced by oral ART (5.03; 1.47 − 17.15), daily intake (14.65; 3.44–62.46), carrying HIV pills constantly (7.19; 2.88 − 17.96), and taking multiple medications (3.94; 1.58 − 9.85). Among the 154 physicians surveyed, 45.5% believed LAI-ART would be the preferred option for patients. Although most physicians (92.9%) thought LAI-ART could improve patients' quality of life (QoL), concerns were raised by 37.7% and 44.2% of them regarding injection site pain and visit rescheduling, respectively. Interest in LAI-ART was higher among men, those aged <50 years, and individuals finding their oral ART inconvenient. Physicians believed LAI-ART could improve QoL and overcome treatment challenges, yet concerns were raised about its potential usage difficulties. Although most patients were interested in receiving LAI-ART, only less than half of the physicians considered it their preferred option, likely owing to concerns about missed visits and injection site pain. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Sharp increase in gonorrhoea notifications among young people, EU/EEA, July 2022 to June 2023

Author

Nerlander, Lina, primary, Champezou, Lydia, additional, Gomes Dias, Joana, additional, Aspelund, Gudrun, additional, Berlot, Lina, additional, Constantinou, Elisavet, additional, Díaz, Asunción, additional, Epštein, Jevgenia, additional, Fogarassy, Erika, additional, Hernando, Victoria, additional, Hoffmann, Patrick, additional, Igoe, Derval, additional, Klavs, Irena, additional, Pinto Leite, Pedro, additional, Liitsola, Kirsi, additional, McIntyre, Angeline, additional, Molnár, Zsuzsanna, additional, Olsen, Anne Olaug, additional, Pires-Afonso, Yolanda, additional, Putniņa, Renāte, additional, Rudaitis, Kęstutis, additional, Siakallis, Georgios, additional, de Stoppelaar, Sacha, additional, Suligoi, Barbara, additional, Hannila-Handelberg, Tuula, additional, Velicko, Inga, additional, Cabral Veríssimo, Vítor, additional, Visser, Maartje, additional, Wessman, Maria, additional, and Mårdh, Otilia, additional

Published
2024
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7. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo-Dorado, Jesús, Bravo-Ferrer, José, Salamanca, Elena, Palacios-Baena, Zaira R., Pérez-Palacios, Patricia, Gandullo-Moro, María, Ruíz-Hueso, Rocío, Moya-González, Natalia, Valido-Morales, Agustín, Pavón-Masa, María, Díaz Menéndez, Marta, De la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, De Miguel Buckley, Rosa, Cadiñanos Loidi, Julen, Busca Arenzana, Carmen, Mican Rivera, Rafael, Mora Rillo, Marta, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Montejano Sánchez, Rocío, Diaz Pollan, Beatriz, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E, Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Such-Diaz, Ana, Álvaro-Alonso, Elena, Izquierdo-García, Elsa, Torres-Macho, Juan, Cuevas, Guillermo, Notario, Helena, Mestre-Gómez, Beatriz, Jiménez-González de Buitrago, Eva, Fernández-Jiménez, Inés, Tebar-Martínez, Ana Josefa, Brañas, Fátima, Valencia, Jorge, Pérez-Butragueño, Mario, Alvarado, Marta, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Cisneros, José Miguel, Amodeo, Cristina, Camacho, Pedro, Espinosa, Nuria, García-Gutiérrez, Manuel, Jara-Palomares, Luis, González-León, Rocío, Molina, José, Nieto Martín, María Dolores, Paniagua, María, Poyato, Manuel, Rodríguez-Villodres, Ángel, Ruiz de Azua, Zaida, Salamanca, Celia, Sepúlveda Berrocal, Mº Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Rivas-Carmenado, María, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jodar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Sande Llovo, Diana, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Letang, Emilio, Arenas-Miras, María del Mar, Gómez-Zorrilla, Silvia, Sánchez Martínez, Francesca, Lerma-Chippirraz, Elisabet, García Vázquez, Elisa, Moral Escudero, Encarnación, Roura Piloto, Aychel Elena, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Navarro López, Jorge, Balsa Vázquez, Javier, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz De Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Jorge García, Ruth, Molina Torres, Nora, Sempere Alcocer, Marco Antonio, De Castro Vega, Francisco Javier, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Oltra Sempere, María Rosa, Vela Berna, Sara, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, De la Vega, Alexandra, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Ribera Puig, Alba, Ortega Enciso, Lucía, Sanz Salvador, Xavier, Losa García, Juan Emilio, Velasco Arribas, María, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón De Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucía, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jésica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J, Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, Correa Ruiz, Ana, García de Lomas Guerrero, José Mº, Daniel López, Daniel, Marinas, Rebeca, Morando, Marta, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Jaén Sánchez, Nieves, Orihuela Martín, Jorge, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Salavert Lletí, Miguel, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mº Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macia, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Sánchez Pernaute, Olga, Fernández Espinilla, Virginia, Castrodeza Sanz, José Javier, Dueñas Gutiérrez, Carlos Jesús, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Estébanez Muñoz, Miriam, Ramírez-Olivencia, Germán, Herrero Mendoza, María Dolores, De Dios García, Begoña, Mata Forte, Tatiana, Rodríguez Fernández, José María, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Sanjosé Muñiz, Irene, Molina Iturritza, Estíbaliz, Ganchegui Aguirre, Maite, Urrestarazu Larrañag, Miren, De la Higuera Arranz, Carmen, Álvarez Padín, Pilar, Iglesias Llorente, Laura, Román Bernal, Berta, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, Villamarín, Miguel, Fernández, Nuria, Salvador, Fernando, Bosch-Nicolau, Pau, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Cosmen Sánchez, Ana, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Mora Delgado, Juan, Manso Gómez, Tamara, Rubio Obanos, Teresa, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Adalid Moll, María, Díaz Luperena, Javier, Ruiz Grinspan, Martín Sebastián, Barrós González, Raquel, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Bustinduy Odriozola, Maria Jesús, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, Arriola Martínez, Paula, Lartategi Iraurgi, Alazne, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Asschert Agüero, Isabel, Chamarro Martí, Elena, Franch Llasat, Diego, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Martínez López, Belén, García-López, María, Fernández Cruz, Ana, Calderón Parra, Jorge, Ramos Martínez, Antonio, Múñez Rubio, Elena, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Díaz de Santiago, Alberto, De la Fuente Moral, Sara, Pintos Pascual, Ilduara, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Martínez Vidal, Ana, Talavera García, Eva, Mendoza Roy, Paula, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Bañón Escandell, Sara, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Herrero Rodríguez, Carmen, Liébana Martos, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José L, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Vizcarra, Pilar, Rodriguez Dominguez, Mario José, Gioia, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Martín Dávila, Pilar, Casado, José Luis, Oteo Revuelta, José Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José Ramón, Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Gredilla Zubiría, Íñigo, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Frías, Jesús, Ramírez, Elena, Martín-Quirós, Alejandro, Quintana-Díaz, Manuel, Mingorance, Jesús, Arnalich, Francisco, Moreno, Francisco, Figueiras, Juan Carlos, García-Arenzana, Nicolás, Montero-Vega, María Dolores, Romero-Gómez, María Pilar, Toro-Rueda, Carlos, García-Bujalance, Silvia, Ruiz-Carrascosa, Guillermo, Cendejas-Bueno, Emilio, Falces-Romero, Iker, Lázaro-Perona, Fernando, Ruiz-Bastián, Mario, Gutiérrez-Arroyo, Almudena, Girón De Velasco-Sada, Patricia, Dahdouh, Elie, Gómez-Arroyo, Bartolomé, García-Sánchez, Consuelo, Guedez-López, Virginia, Bloise-Sánchez, Iván, Alguacil-Guillén, Marina, Liras-Hernández, Maria Gracia, Sánchez-Castellano, Miguel Angel, García-Clemente, Paloma, González-Donapetry, Patricia, San José-Villar, S, de Pablos-Gómez, Manuela, Gómez-Gil, Rosa, Corcuera-Pindado, Maria Teresa, Rico-Nieto, Alicia, Herrero, Alicia, Prieto-Arribas, Daniel, Oliver-Saez, Paloma, Mora-Corcovado, Roberto, Fernández-Calle, Pilar, Alcaide-Martín, María José, Díaz-Garzón, Jorge, Fernández-Puntero, Belén, Nuñez-Cabetas, Rocío, Crespo-Sánchez, Gema, Rodriguez-Fraga, Olaia, Mendez del Sol, Helena, Duque-Alcorta, Marta, Gomez-Rioja, Rubén, Sanz de Pedro, María, Pascual-García, Lydia, Segovia-Amaro, Marta, Iturzaeta-Sánchez, Jose Manuel, Rodriguez-Gutiérrez, Mercedes, Perez-Garcia Morillón, Amparo, Martinez Gallego, Miguel Angel, Fabre-Estremera, Blanca, Martinez-Chavez, Estefanía, Moreno-Parra, Isabel, Rodriguez-Roca, Neila, Ortiz-Sánchez, Daniel, Simon-Velasco, Manuela, Gabriela-Tomoiu, Ileana, Pizarro-Sanchez, Cristina, Montero-San Martín, Blanca, Qasem-Moreno, Ana Laila, Gómez-López, Marta, Casares Guerrero, Ismael, Buño-Soto, Antonio, Martí de Gracia, Milagros, Parra-Gordo, Luz, Diez-Tascón, Aurea, Ossaba-Vélez, Silvia, Pinilla, Inmaculada, Cuesta, Emilio, Fernández-Velilla, María, Torres, Maria Isabel, Garzón, Gonzalo, Pérez-Blanco, Verónica, Quintás-Viqueira, Almudena, San Juan, Isabel, Cantero-Escribano, José Miguel, Pérez-Romero, César, Castro-Martínez, Mercedes, Hernández-Rivas, Lucía, Pedraz, Teresa, Fernández-Bretón, Eva, García-Vaz, Claudia, Robustillo-Rodela, Ana, Torres Santos-Olmo, Rosario María, Rivera-Núñez, Angélica, Fernández-Fernández, Ignacio, Noguerol-Gutiérrez, Marina, Martínez-Virto, Ana María, González-Viñolis, Manuel, Cabrera-Gamero, Regina, Mayayo-Alvira, Rosa, Marín-Baselga, Raquel, Lo-Iacono García, Victoria, Lerín-Baratas, Macarena, Romero Gallego-Acho, Paloma, Reche-Martínez, Begoña, Tejada-Sorados, Renzo, Rico-Briñas, Mikel, Deza-Palacios, Ricardo, Fabra-Cadenas, Sara, Arroyo-Rico, Isabel, Ben-Abdellah, Lubna Dani, Labajo-Montero, Laura, Soriano-Arroyo, Rubén, López-Corcuer, Lorena, Calvin-García, Elena, Martínez-Álvarez, Susana, López-Tappero Irazábal, Laura, Pilares-Barco, Martín, González-Peña, Olga, Bejarano-Redondo, Guillermina, Iglesias-Sigüenza, Alberto, Tung-Chen, Yale, Maroun Eid, Charbel, Bravo-Lizcano, Ruth, Silvestre-Niño, Miguel, Perdomo-García, Frank, Alonso-González, Berta, Antón-Huguet, Berta, Arenas-Berenguer, Isabel, Cabré-Verdiell Surribas, Clara, Marqués-González, Francisco, Muñoz del Val, Elena, Ángeles Molina, María, Cancelliere-Fernández, Nataly, Pastor-Yvorra, Sivia, Frade-Pardo, Laura, López-Arévalo, Paloma, García, Isabel, Fernández-Capitán, Carmen, González-Garcia, Juan José, Herrero, Juan, Quesada Simón, María Angustias, Robles Marhuenda, Angel, Soto Abanedes, Clara, Noblejas Mozo, Ana María, Ramos, Juan Carlos, Jaras Hernandez, María Jesús, Martinez Robles, Elena, Moreno Fernandez, Alberto, Sanchez Purificación, Aquilino, Martin Gutiérrez, Juan Carlos, Martinez Hernández, Pedro Luis, Sancho Bueso, Teresa, Lorenzo Hernández, Alicia, Gutierrez Sancerni, Belén, Salgueiro, Giorgina, Martin Carbonero, Luz, Mostaza, Jose María, Martinez-López, María Angeles, Hontañón, Victor, Menéndez, Araceli, Alvarez Troncoso, Jorge, Castellano, Arancha, Marcelo-Calvo, Cristina, Vives-Beltrán, Ivo, Ramos Ruperto, Luis, Daroca-Bengoa, Germán, Arcos Rueda, María, Vasquez-Manau, Julia, Fernández Cidón, Pelayo, Rosario Herrero Gil, Carmen, Palmier Peláez, Esmeralda, Untoria Tabares, Yeray, Lahoz, Carlos, Estirado, Eva, Hernández, Clara, Garcia-Iglesias, Francisca, Monteoliva, Enrique, Martínez, Mónica, Vara, Marta, González Alegre, Teresa, Valencia, Maria Eulalia, Moreno, Victoria, Montes, Maria Luisa, Alcolea-Batres, Sergio, Cabanillas-Martín, Juan José, Carpio-Segura, Carlos, Casitas-Mateo, Raquel, Fernández-Bujarrabal Villoslada, Jaime, Fernández-Navarro, Isabel, Fernández-Lahera, Juan, García-Quero, Cristina, Hidalgo-Sánchez, María, Galera-Martínez, Raúl, García-Río, Francisco, Gómez-Carrera, Luis, Gómez-Mendieta, María Antonia, Mangas-Moro, Alberto, Martínez-Cerón, Elisabet, Martínez-Redondo, María, Martínez-Abad, Yolanda, Martínez-Verdasco, Antonio, Plaza-Moreno, Cristina, Quirós-Fernández, Sarai, Romera-Cano, Delia, Romero-Ribate, David, Sánchez-Sánchez, Begoña, Santiago-Recuerda, Ana, Villasante, Carlos, Zamarrón de Lucas, Ester, Arnalich-Montiel, Victoria, Mariscal-Aguilar, Pablo, Falcone, Adalgisa, Laorden-Escudero, Daniel, Prados Sánchez, María Concepción, Álvarez-Sala Walther, Rodolfo, García, Andony, Arévalo, Cristina, Gutiérrez, Carola, Yus, Santiago, Asensio, Maria José, Sánchez, Manolo, Añón, Jose Manuel, Manzanares, Jesús, García de Lorenzo, Abelardo, Perales, Eva, Civantos, Belén, Cachafeiro, Lucía, Agrifoglio, Alexander, Estébanez, Belén, Flores, Eva, Hernández, Mónica, Millán, Pablo, Rodríguez, Montserrat, Nanwani, Kapil, Arizcun, Beatriz, Pérez-Costa, Elena, Rodríguez-Álvarez, Diego, Sánchez-Martín, María, Quesada, Úrsula, Román-Hernández, Carmen, Dorao, Paloma, Álvarez-Rojas, Elena, Menéndez, Juan José, Verdú, Cristina, Gómez-Zamora, Ana, Schüffelmann, Cristina, Calderón-Llopis, Belén, Laplaza-González, María, Río-García, Miguel, Amores-Hernández, Irene, Rodríguez-Rubio, Miguel, de la Oliva, Pedro, Ruiz, Jose, Rosillo, Sandra, González, Oscar, Iniesta, Angel, Ponz, Ines, Muñoz-Ramón, José María, Hernández-Gancedo, María, Uña Orejón, Carmen R., Sanabria-Carretero, Pascual, Moreno Gómez-Limón, Isidro, Seiz-Martinez, Alverio, Guasch-Arévalo, Emilia, Martín-Carrasco, Cristina, Alvar, Elena, Serrá, Lucía, Iannuccelli, Fabricio, Latorre, Julieta, Casares, Sandra, Valbuena, Isabel, Díaz Díez Picazo, Luis, Rodríguez Roca, Cristina, Cervera, Omar, García de las Heras, Esteban, Durán, Pilar, Castro, Carmen, Manrique de Lara, Carlos, Veganzones, Javier, López-Tofiño, Araceli, Fernandez-Cerezo, Estefanía, Zurita, Sergio, López-Martinez, Mercedes, Prim, Teresa, Alvárez del Vayo, Julía, Alcaraz, Gabriela, Castro, Luis, Yagüe, Julio, Díaz-Carrasco, Sofía, González-Pizarro, Patricio, Montero, Ana, Sagra, Francisco Javier, Suárez, Alejandro, Díez-Porres, Leyre, Varela-Cerdeira, María, Alonso-Babarro, Alberto, Abellán Martínez, Francisco, Alonso-Eiras, Jorge Ignacio, Álvarez Brandt, Alejandra, Archinà, Martina, Arribas-Terradillos, Silvia, Baselga-Puente, Trinidad, Barco Núñez, Pilar, Barrera-López, Natalia Guadalupe, Barrera-López, Lorena, Bartrina-Tarrio, Andres, Bassani, Gemma, Betancort de la Torre, Paula, Blanco-Bartolomé, Irene, Blasco-Andres, Celia, Brieba-Plata, Lucía, Cadenas-Gota, Fernando, Carrera-Vázquez, Paloma, Cascajares-Sanz, Carlota, Catino, Arianna, Cavallé-Pulla, Raquel, Ceniza-Pena, Daniel, Conde-Alonso, Ylenia María, Currás-Sánchez, Laura, Daltro-Lage, Marcelo, Esteban-Romero, Ana, Fernández Vidal, María Luisa, Ferrer Ortiz, Inés, de la Fuente Regaño, Lydia, Galindo-Ballesteros, Pablo, Garcia-Bellido Ruiz, Sara, García-Mochales Fortún, Carlos, Gómez-Ballesteros, Teresa, Gómez-Domínguez, Cecilia, González-Aguado, Nelsa, González-García, Sofía, Guisández Martín, Jorge, Hernández-Liebo, Paula Alejandra, Hernando Nieto, Raquel, Llorente-Cortijo, Irene María, Marín-García, Antonio, López-Pirez, Pilar, Mejuto-Illade, Lucía, Palma, Marco, Peña-Hidalgo, Adrian, Platero-Dueñas, Lucía, Pujol-Pocull, David, Ramírez-Verdyguer, Miguel, Redondo-Gutierrez, Marta, Reinoso-Lozano, Francisco, Rodríguez-Revillas, Ana, Rodríguez Saenz de Urturi, Alejandro, Romero-Imaz, Lucía, Sánchez-Rico, Susana, Sánchez-Santiuste, Mónica, Serrano de la Fuente, Patricia, Serrano-Martín, Henar, Silva-Freire, Thamires, Soria-Alcaide, Eva, Suárez-Plaza, Andrés Enrique, Tejero-Soriano, Beatriz, Torrecillas-Mainez, Andrea, Torres-Cortés, Javier, Valentín-Pastrana Aguilar, María de las Mercedes, Villanueva-Freije, Angélica, Virgós-Varela, Marta, Yagüe-Barrado, Marta, Yustas-Benitez, Natalia, Nuñez, María Concepción, Montserrat, Jaime, Queiruga, Javier, Rodriguez-Mariblanca, Amelia, Martínez de Soto, Lucía, Urroz, Mikel, Seco, Enrique, Zubimendi, Mónica, Stuart, Stephan, Díaz, Lucía, García, Irene, García Morales, María Teresa, Martín-Vega, Alberto, Caro, Abel, Martínez-Alés, Gonzalo, Gutiérrez-Gutiérrez, Belén, del Toro, María Dolores, Borobia, Alberto M, Carcas, Antonio, Jarrín, Inmaculada, Yllescas, María, Ryan, Pablo, Pachón, Jerónimo, Carratalà, Jordi, Berenguer, Juan, Arribas, Jose Ramón, and Rodríguez-Baño, Jesús

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2021
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8. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

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Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E., Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Berenguer, Juan, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Lago Núñez, Mª del Mar, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Busca Arenzana, Carmen, Mican, Alfredo, Mora Rillo, Marta, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Arribas López, José Ramón, Such Diaz, Ana, Álvaro Alonso, Elena, Izquierdo García, Elsa, Torres Macho, Juan, Cuevas Tascon, Guillermo, Troya García, Jesús, Mestre Gómez, Beatriz, Jiménez González de Buitrago, Eva, Fernández Jiménez, Inés, Tebar Martínez, Ana Josefa, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Alvarado Blasco, Marta, Ryan, Pablo, Sepúlveda Berrocal, Mª Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Asensi Álvarez, Víctor, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jódar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Brea Aparicio, Ruth, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Knobel, Hernando, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Sorli Redò, Luisa, Güerri-Fernández, Roberto, Milagro Montero, María, Horcajada, Juan Pablo, García Vázquez, Elisa, Moral Escudero, Encarnación, Hernández Torres, Alicia, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Sierra Rodríguez, Rodrigo, Alonso Menchén, David, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz de Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Sáez Escolano, Paula, Bejarano Tello, Esperanza, Sempere Alcocer, Marco Antonio, Álvarez Martin, Salvador, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Abascal Cambras, Ivette, Pérez Jaén, Ana del Cielo, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Ferrer Ribera, Ana, Bea Serrano, Carlos, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Julia, Clemente Presas, Mercedes, Losa García, Juan Emilio, Vegas Serrano, Ana, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón de Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucia, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jessica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J., Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, De la Torre Lima, Javier, García de Lomas Guerrero, José Mª, Morte, Elena, Loscos, Silvia, Camón, Ana, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Tosco Núñez, Tomás, Aroca Ferri, María, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Baño, Jesús Rodriguez, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo, Jesús, Gutiérrez-Gutiérrez, Belén, Bravo-Ferrer, José, Salamanca, Elena, Palacios, Zaira R., Pérez-Palacios, Patricia, Peral, Enrique, Pérez de León, José Antonio, Sánchez-Gómez, Jesús, Marín-Barrera, Lucía, García-Jiménez, Domingo, Carratalà, Jordi, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Salavert Lletí, Miguel, Castro Hernández, Iván, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mª Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macias, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Milicua Muñoz, José María, Fernández Espinilla, Virginia, Dueñas Gutiérrez, Carlos Jesús, Hernán García, Cristina, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Fernández-González, Pablo, Alcántara Nicolás, Francisco, Aguirre Vila-Cora, Alejandro, López Tizón, Elena, Ramírez-Olivencia, Germán, Estébanez Muñoz, Miriam, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Balerdi Sarasola, Leire, Morales García, Cristina, Corral Saracho, Miguel, Valcarce González, Zeltia, Arenal Andrés, Noelia, Rodríguez Tarazona, Raquel Elisa, Iglesias Llorente, Laura, Loureiro Rodríguez, Beatriz, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, García, Sonia, Marzo, Blanca, Villamarín, Miguel, Fernández, Nuria, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, García Villalba, Eva Pilar, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Naranjo Velasco, Virginia, Manso Gómez, Tamara, Quilez Ágreda, Delia, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Alonso Navarro, Rodrigo, Ampuero Martinich, Jose David, Barrós González, Raquel, Galindo Martín, María Aránzazu, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Ibarguren Pinilla, Maialen, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, García Gómez, Miriam, Aranguren Arostegui, Asier, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Muñoz Beamud, Francisco, Chamarro Martí, Elena, Cardona Rivera, Merce, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Llenas García, Jara, Sánchez Arenas, Mª Carmen, Fernández Cruz, Ana, Calderón Parra, Jorge, López Dosil, Marcos, Ramos Martínez, Antonio, Múñez Rubio, Elena, Callejas Díaz, Alejandro, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Anel Pedroche, Jorge, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Runza Buznego, Paula, Talavera García, Eva, Lamata Subero, Marta, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Molina Peinado, Virginia, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Toda Savall, María Roca, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José Luís, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Cisneros, José Miguel, Pachón, Jerónimo, Aguilar-Guisado, Manuela, Aldabó, Teresa, Avilés, María Dolores, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Gálvez-Benítez, Lydia, Infante, Carmen, Martín, Guillermo, Praena, Julia, Roca, Cristina, Salamanca, Celia, Suárez-Benjumea, Alejandro, Vizcarra, Pilar, Quereda, Carmen, Rodriguez Dominguez, Mario José, Gioia, Francesca, Norman, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Oteo Revuelta José, Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José R., Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Paulos Viñas, Silvia, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Jarrín, Inmaculada, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Rodríguez-Baño, Jesús, Yllescas, María, and Arriba, José Ramón

Published
2020
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9. Effectiveness of Modified Vaccinia Ankara-Bavaria Nordic Vaccination in a Population at High Risk of Mpox: A Spanish Cohort Study.

Author

Fontán-Vela, Mario, Hernando, Victoria, Olmedo, Carmen, Coma, Ermengol, Martínez, Montse, Moreno-Perez, David, Lorusso, Nicola, Torres, María Vázquez, Buey, José Francisco Barbas del, Roig-Sena, Javier, Pastor, Eliseo, Truyols, Antònia Galmés, Serra, Francisca Artigues, Martínez, Rosa María Sancho, Zamalloa, Pello Latasa, Martínez, Olaia Pérez, Estepa, Ana Vázquez, Rojas, Amós José García, Estévez, Ana Isabel Barreno, and Naranjo, Alonso Sánchez-Migallón

Subjects
*VIRAL disease prevention, *HIV-positive persons, *HIV infections, *CONFIDENCE intervals, *COMMUNICABLE diseases, *MONKEYPOX, *IMMUNOMODULATORS, *SMALLPOX vaccines, *PRE-exposure prophylaxis, *VACCINE effectiveness, *RISK assessment, *DESCRIPTIVE statistics, *KAPLAN-Meier estimator, *VIRUS diseases, *LONGITUDINAL method, *DISEASE risk factors, *EVALUATION
Abstract

Background With more than 7500 cases reported since April 2022, Spain has experienced the highest incidence of mpox in Europe. From 12 July onward, the modified vaccinia Ankara-Bavaria Nordic (MVA-BN) smallpox vaccine was offered as pre-exposure prophylaxis for those receiving pre-exposure prophylaxis for human immunodeficiency virus (HIV-PrEP). Our aim was to assess the effectiveness of 1 dose of MVA-BN vaccine as pre-exposure prophylaxis against mpox virus (MPXV) infection in persons on HIV-PrEP. Methods National retrospective cohort study between 12 July and 12 December 2022. Individuals aged ≥18 years receiving HIV-PrEP as of 12 July with no previous MPXV infection or vaccination were eligible. Each day, we matched individuals receiving a first dose of vaccine and unvaccinated controls of the same age and region. We used a Kaplan–Meier estimator, calculated risk ratios (RR) and vaccine effectiveness (VE = [1 − RR]x100). Results We included 5660 matched pairs, with a median follow-up of 62 days (interquartile range, 24–97). Mpox cumulative incidence was 5.6 per 1000 (25 cases) in unvaccinated and 3.5 per 1000 (18 cases) in vaccinated. No effect was found during days 0–6 post-vaccination (VE, −38.3; 95% confidence interval [CI], −332.7 to 46.4), but VE was 65% at ≥7 days (95% CI, 22.9 to 88.0) and 79% at ≥14 days (95% CI, 33.3 to 100.0) post-vaccination. Conclusions One dose of MVA-BN vaccine offered protection against mpox in most-at-risk population shortly after the vaccination. Further studies need to assess the VE of a second dose and the duration of protection over time. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Vaccination trends in people with HIV infection participanting in the hospital-based survey of patients infected with HIV, 2006–2021

Author

Hernando, Victoria, primary, Suárez, Lucia, additional, Gutiérrez, Gonzalo, additional, López, Juan Carlos, additional, Navarro-Soler, Roser, additional, Cabello, Alfonso, additional, Sanz, Jesús, additional, Suarez-García, Inés, additional, Fernández, Maria Teresa, additional, Losa, Juan Emilio, additional, Pérez, Jose Luis, additional, Ramos-Ruperto, Luis, additional, Pérez-Elías, Maria Jesús, additional, Aayuni, Wafa Ben Cheikh El, additional, Cuesta, Mar, additional, González, Gustavo, additional, Izquierdo, Ana, additional, Viloria, Luis, additional, López, Irene, additional, Martínez, Eva, additional, Castrillejo, Daniel, additional, Jaume Amengual, Maria Glòria, additional, Belmonte, Maria Antonia, additional, Arraiza, Antonio, additional, de la Torre, Javier, additional, Miqueleiz, Estrella, additional, Marcos, Henar, additional, Ruiz-Algueró, Marta, additional, Villegas, Teresa, additional, Simón, Lorena, additional, and Diaz, Asuncion, additional

Published
2023
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11. The Human Immunodeficiency Virus Continuum of Care in European Union Countries in 2013: Data and Challenges

Author

European HIV Continuum of Care Working Group, Gourlay, Annabelle, Noori, Teymur, Pharris, Anastasia, Axelsson, Maria, Costagliola, Dominique, Cowan, Susan, Croxford, Sara, Monforte, Antonella d'Arminio, del Amo, Julia, Delpech, Valerie, Díaz, Asunción, Girardi, Enrico, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Jose, Sophie, Leierer, Gisela, Nikolopoulos, Georgios, Obel, Niels, de Coul, Eline Op, Paraskeva, Dimitra, Reiss, Peter, Sabin, Caroline, Sasse, André, Schmid, Daniela, Sonnerborg, Anders, Spina, Alexander, Suligoi, Barbara, Supervie, Virginie, Touloumi, Giota, Van Beckhoven, Dominique, van Sighem, Ard, Vourli, Georgia, Zangerle, Robert, and Porter, Kholoud

Published
2017

13. Microbiological analysis of acute hepatitis of unknown aetiology in children in Spain

Author

Calvo, Ana Avellon, primary, Munoz-Chimeno, Milagros, additional, Varela, Carmen, additional, Guerrero, Maria, additional, Peñuelas, Marina, additional, Morago, Lucia, additional, Sanchez, Nazaret, additional, Gonzalez, Monica, additional, Tarrago, David, additional, Echevarria, Juan Emilio, additional, Fernandez, Maria Dolores, additional, Escudero, Raquel, additional, Pozo, Francisco, additional, Varona, Sarai, additional, Hernando, Victoria, additional, and Diaz, Asuncion, additional

Published
2023
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14. Reduction in the risk of mpox infection after MVA-BN vaccination in individuals on HIV pre-exposure prophylaxis: a Spanish cohort study

Author

Fontan-Vela, Mario, primary, Hernando, Victoria, additional, Olmedo, Carmen, additional, Coma, Ermengol, additional, Martinez, Montse, additional, Moreno, David, additional, Lorusso, Nicola, additional, Vazquez Torres, Maria, additional, Barbas del Buey, Jose Francisco, additional, Roig, Javier, additional, Pastor, Eliseo, additional, Galmes Truyols, Antonia, additional, Artigues Serra, Francisca, additional, Sancho Martinez, Rosa Maria, additional, Latasa Zamalloa, Pello, additional, Perez Martinez, Olaia, additional, Vazquez Estepa, Ana, additional, Garcia Rojas, Amos, additional, Barreno Estevez, Ana Isabel, additional, Sanchez-Migallon Naranjo, Alonso, additional, Perez Martin, Jaime Jesus, additional, Peces Jimenez, Pilar, additional, Morales Romero, Raquel, additional, Castilla, Jesus, additional, Garcia Cenoz, Manuel, additional, Huerta, Marta, additional, Boone, An Lieve Dirk, additional, Macias Ortiz, Maria Jose, additional, Alvarez Rio, Virginia, additional, Rodriguez Recio, Maria Jesus, additional, Merino Diaz, Maria, additional, Berradre Saenz, Belen, additional, Teresa-Villegas, Maria, additional, Limia, Aurora, additional, Diaz, Asuncion, additional, and Monge, Susana, additional

Published
2023
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15. Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?

Author

Vourli, Georgia, Pharris, Anastasia, Cazein, Francoise, Costagliola, Dominique, Dabis, Francois, Del Amo, Julia, Delpech, Valerie, Díaz, Asuncion, Girardi, Enrico, Gourlay, Annabelle, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Nikolopoulos, Georgios, Porter, Kholoud, Rosińska, Magdalena, Sabin, Caroline, Suligoi, Barbara, Supervie, Virginie, Wit, Ferdinand, and Touloumi, Giota

Published
2018
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17. Effectiveness and tolerability of dolutegravir/lamivudine for the treatment of HIV-1 infection in clinical practice

Author

Suárez García, Inés, Alejos, Belén, Hernando, Victoria, Viñuela, Laura, Vera García, Mar, Rial Crestelo, David, Pérez Elías, María Jesús, Albendín Iglesias, Helena, Peraire, Joaquim, and Spanish HIV/AIDS Research Network (CoRIS)

Subjects
Tratamiento médico, Inhibidores de Integrasa VIH, Sida, Virología
Abstract

Objectives To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018–2021. Methods We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL)

Published
2023

18. Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?

Author

Vourli, Georgia, Pharris, Anastasia, Cazein, Francoise, Costagliola, Dominique, Dabis, Francois, Del Amo, Julia, Delpech, Valerie, Díaz, Asuncion, Girardi, Enrico, Gourlay, Annabelle, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Nikolopoulos, Georgios, Porter, Kholoud, Rosińska, Magdalena, Sabin, Caroline, Suligoi, Barbara, Supervie, Virginie, Wit, Ferdinand, and Touloumi, Giota

Published
2019
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20. Impact of Risk Factors for Specific Causes of Death in the First and Subsequent Years of Antiretroviral Therapy Among HIV-Infected Patients

Author

Antiretroviral Therapy Cohort Collaboration, Ingle, Suzanne M., May, Margaret T., Gill, M. John, Mugavero, Michael J., Lewden, Charlotte, Abgrall, Sophie, Fätkenheuer, Gerd, Reiss, Peter, Saag, Michael S., Manzardo, Christian, Grabar, Sophie, Bruyand, Mathias, Moore, David, Mocroft, Amanda, Sterling, Timothy R., D'Arminio Monforte, Antonella, Hernando, Victoria, Teira, Ramon, Guest, Jodie, Cavassini, Matthias, Crane, Heidi M., and Sterne, Jonathan A. C.

Published
2014
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21. Effect of Immediate Initiation of Antiretroviral Treatment in HIV-Positive Individuals Aged 50 Years or Older

Author

Lodi, Sara, Costagliola, Dominique, Sabin, Caroline, del Amo, Julia, Logan, Roger, Abgrall, Sophie, Reiss, Peter, van Sighem, Ard, Jose, Sophie, Blanco, Jose-Ramon, Hernando, Victoria, Bucher, Heiner C., Kovari, Helen, Segura, Ferran, Ambrosioni, Juan, Gogos, Charalambos A., Pantazis, Nikos, Dabis, Francois, Vandenhende, Marie-Anne, Meyer, Laurence, Seng, Rémonie, Gill, M. John, Krentz, Hartmut, Phillips, Andrew N., Porter, Kholoud, Grinsztejn, Beatriz, Pacheco, Antonio G., Muga, Roberto, Tate, Janet, Justice, Amy, and Hernán, Miguel A.

Published
2017
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22. Unplanned pregnancies and social and partner support during pregnancy in Spanish women living with HIV.

Author

Ruiz‐Algueró, Marta, Izquierdo, Rebeca, Suárez‐García, Ines, Moreno, Cristina, Alejos, Belen, Rava, Marta, Moreno, Santiago, Montero Alonso, Marta, Gutiérrez, Felix, Gutierrez Cuellar, Isabel, Curran, Adrián, Hernando, Victoria, and Jarrín, Inma

Subjects
SOCIAL support, CONFIDENCE intervals, TELEPHONES, QUESTIONNAIRES, ALCOHOL drinking, DESCRIPTIVE statistics, RESEARCH funding, SOCIODEMOGRAPHIC factors, SMOKING, ODDS ratio, PSYCHOLOGY of HIV-positive persons, UNPLANNED pregnancy, REPRODUCTIVE health, LONGITUDINAL method, SUB-Saharan Africans
Abstract

Objectives: To describe prevalence and factors associated with unplanned pregnancies, and social and partner support during pregnancy among women from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: We included all women recruited in CoRIS from 2004 to 2019, aged 18–50 years at recruitment who were pregnant during 2020. We designed a questionnaire, organized into the following domains: sociodemographic characteristics, tobacco and alcohol consumption, pregnancy and reproductive health, and social and partner support. The information was gathered via telephone interviews conducted from June to December 2021. We calculated prevalence of unplanned pregnancies as well as odds ratios (ORs) of association and 95% confidence intervals (CIs) according to sociodemographic, clinical and reproductive characteristics. Results: Among 53 women who were pregnant during 2020, 38 (71.7%) answered the questionnaire. Median age at pregnancy was 36 years [interquartile range (IQR) 31–39], 27 (71.1%) women were born outside of Spain, mainly in sub‐Saharan Africa (39.5%) and 17 (44.7%) were employed. Thirty‐four (89.5%) women had been through previous pregnancies and 32 (84.2%) had experienced previous abortions/miscarriages. Seventeen (44.7%) women had shared with their clinician their desire to get pregnant. Thirty‐four (89.5%) pregnancies were natural and four used assisted reproductive techniques (in vitro fertilizations; one additionally used oocyte donation). Of 34 women with natural pregnancies, pregnancy was unplanned in 21 (61.8%) and 25 (73.5%) had information on how to become pregnant avoiding HIV transmission to the baby and partner. Women who did not seek advice from their physician about becoming pregnant had a significantly increased risk of unplanned pregnancy (OR = 71.25, 95% CI: 8.96–566.67). Overall, 14 (36.8%) women reported having low social support during pregnancy and 27 (71.0%) had good/very good support by their partner. Conclusions: Most pregnancies were natural and unplanned and very few women had talked with their clinician about their desire to become pregnant. A high proportion of women reported low social support during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Effectiveness and tolerability of dolutegravir/lamivudine for the treatment of HIV-1 infection in clinical practice.

Author

Suárez-García, Inés, Alejos, Belén, Hernando, Victoria, Viñuela, Laura, García, Mar Vera, Rial-Crestelo, David, Elías, María Jesús Pérez, Iglesias, Helena Albendín, Peraire, Joaquim, Tiraboschi, Juan, Díaz, Asunción, Moreno, Santiago, Jarrín, Inma, and (CoRIS), the Cohort of the Spanish HIV/AIDS Research Network

Subjects
LAMIVUDINE, RALTEGRAVIR, EMTRICITABINE, DOLUTEGRAVIR, CD4 lymphocyte count, HIV, VIRAL load
Abstract

Objectives To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018–2021. Methods We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) <50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/lamivudine or other first-line ART regimens. Results We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine. The remaining subjects started bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) (n  = 949, 43.9%), DTG + FTC/tenofovir disoproxil fumarate (TDF) (n  = 282, 13.1%), DTG/3TC/abacavir (ABC) (n  = 255, 11.8%), darunavir (DRV)/cobicistat(COBI)/FTC/TAF (n  = 147, 6.8%) and elvitegravir (EVG)/COBI/FTC/TAF (n  = 126, 5.8%). At 24 and 48 weeks after starting dolutegravir/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. The probability of achieving VS with dolutegravir/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV/COBI/FTC/TAF (adjusted OR: 0.47; 95% CI: 0.30–0.74) compared with dolutegravir/lamivudine. For the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. During the first 48 weeks after dolutegravir/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir/lamivudine due to an adverse event. Conclusions In this large multicentre cohort, effectiveness and tolerability of dolutegravir/lamivudine were high among treatment-naive and treatment-experienced subjects. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Temporal trends and geographic variability in the prescription of antiretroviral treatments in people living with hiv in spain, 2004–2020

Author

Ruiz Algueró, Marta, Hernando, Victoria, Riero, María, Blanco Ramos, José Ramón, Zárraga Fernández, Miguel Alberto de, Galindo, Pepa, Pérez González, Alexandre, Díaz, Asunción, Suárez García, Inés, Jarrín, Inmaculada, CoRIS, Instituto de Salud Carlos III, Red de Investigación Cooperativa en Investigación en Sida, European Regional Development Fund, and Plan Nacional de I+D+i (España)

Subjects
Tratamiento médico, Sida, Estudios de cohortes, Cohort studies, General Medicine, antiretroviral therapy, trends, HIV infection, cohort studies, Trends, Terapia antirretroviral altamente activa, Antiretroviral therapy
Abstract

Background: The purpose of this study was to describe temporal trends in the use of antiretroviral therapy (ART) among people living with HIV (PLWHIV) from the cohort of the Spanish HIV/AIDS research network (CoRIS), 2004-2020. Methods: We described the yearly evolution of the proportion of patients receiving ART and the most frequently prescribed antiretroviral drugs among newly recruited treatment-naïve patients and among all patients with active follow-up. Results: Of 15,539 patients included, 14,618 (94.1%) started ART during their follow-up. Regarding initial regimens, the use of 2NRTI plus 1NNRTI (which were the most frequently prescribed until 2014) and 2NRTI plus 1bPI decreased after 2014, being gradually replaced by INI-based triple therapies. Since 2019, other regimens started to be prescribed, mainly dual therapies. TDF/FTC/EFV was the single-tablet regimen (STR) most frequently prescribed as initial ART until 2012, decreasing thereafter as TDF/FTC/RPV, TDF/FTC/EVG/COBI, and ABC/3TC/DTG became available. TAF/FTC/BIC accounted for 53.6% of initial prescriptions in 2020, followed by DTG/3TC (24%). The percentage of patients on ART increased from 45.7% in 2004 to 98.2% in 2020. Among all patients receiving ART, regimens based on 2NRTI plus 1INI increased from 0.1% in 2007 to 53.3% in 2020. During 2007-2015, most patients were receiving TDF/FTC/EFV, which was replaced after 2017 by ABC/3TC/DTG. In 2020, 13.0% of patients were receiving dual therapies. Conclusions: Robust real-world data on ART use in PLWHIV over more than 15 years show historical trends in prescriptions with an unprecedented visualization of the contemporary treatment patterns. Instituto de Salud Carlos III Red Temática deInvestigación Cooperativa en Sida (RD06/006, RD12/0017/0018 y RD16/0002/0006 Instituto de Salud Carlos III-Subdirección General deEvaluación y el Fondo Europeo de Desarrollo Regional (FEDER) 4.964 JCR (2021) Q2, 54/172 Medicine, General & Internal 1.040 SJR (2021) Q1, 438/2489 Medicine (miscellaneous) No data IDR 2020 UEM

Published
2022

31. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

Author

Gutiérrez-Gutiérrez, Belén, primary, del Toro, María Dolores, additional, Borobia, Alberto M, additional, Carcas, Antonio, additional, Jarrín, Inmaculada, additional, Yllescas, María, additional, Ryan, Pablo, additional, Pachón, Jerónimo, additional, Carratalà, Jordi, additional, Berenguer, Juan, additional, Arribas, Jose Ramón, additional, Rodríguez-Baño, Jesús, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, Retamar, Pilar, additional, Valiente, Adoración, additional, López-Cortés, Luis E., additional, Sojo-Dorado, Jesús, additional, Bravo-Ferrer, José, additional, Salamanca, Elena, additional, Palacios-Baena, Zaira R., additional, Pérez-Palacios, Patricia, additional, Gandullo-Moro, María, additional, Ruíz-Hueso, Rocío, additional, Moya-González, Natalia, additional, Valido-Morales, Agustín, additional, Pavón-Masa, María, additional, Díaz Menéndez, Marta, additional, De la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, De Miguel Buckley, Rosa, additional, Cadiñanos Loidi, Julen, additional, Busca Arenzana, Carmen, additional, Mican Rivera, Rafael, additional, Mora Rillo, Marta, additional, Loeches Yagüe, Belén, additional, Bernardino de la Serna, José Ignacio, additional, García Rodríguez, Julio, additional, Montejano Sánchez, Rocío, additional, Diaz Pollan, Beatriz, additional, López, Juan Carlos, additional, Ramírez-Schacke, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Parras, Francisco, additional, Catalán, Pilar, additional, García-Leoni, María E, additional, Pérez-Tamayo, Isabel, additional, Puente, Luis, additional, Cedeño, Jamil, additional, Such-Diaz, Ana, additional, Álvaro-Alonso, Elena, additional, Izquierdo-García, Elsa, additional, Torres-Macho, Juan, additional, Cuevas, Guillermo, additional, Notario, Helena, additional, Mestre-Gómez, Beatriz, additional, Jiménez-González de Buitrago, Eva, additional, Fernández-Jiménez, Inés, additional, Tebar-Martínez, Ana Josefa, additional, Brañas, Fátima, additional, Valencia, Jorge, additional, Pérez-Butragueño, Mario, additional, Alvarado, Marta, additional, Abelenda-Alonso, Gabriela, additional, Ardanuy, Carmen, additional, Bergas, Alba, additional, Cuervo, Guillermo, additional, Domínguez, María Ángeles, additional, Fernández-Huerta, Miguel, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Pérez-Recio, Sandra, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Trullen, Núria, additional, Cisneros, José Miguel, additional, Amodeo, Cristina, additional, Camacho, Pedro, additional, Espinosa, Nuria, additional, García-Gutiérrez, Manuel, additional, Jara-Palomares, Luis, additional, González-León, Rocío, additional, Molina, José, additional, Nieto Martín, María Dolores, additional, Paniagua, María, additional, Poyato, Manuel, additional, Rodríguez-Villodres, Ángel, additional, Ruiz de Azua, Zaida, additional, Salamanca, Celia, additional, Sepúlveda Berrocal, Mº Antonia, additional, Yera Bergua, Carmen, additional, Toledano Sierra, Pilar, additional, Cano Llorente, Verónica, additional, Zafar Iqubal-Mirza, Sadaf, additional, Muñiz, Gema, additional, Martín Pérez, Inmaculada, additional, Mozas Moriñigo, Helena, additional, Alguacil, Ana, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Goikoetxea Agirre, Josune, additional, Blanco Vidal, María José, additional, Nieto Arana, Javier, additional, del Álamo Martínez de Lagos, Mikel, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Silvariño Fernández, Rafael, additional, Ugalde Espiñeira, Jon, additional, Rivas-Carmenado, María, additional, Suárez Pérez, Lucia, additional, Suárez Diaz, Silvia, additional, Yllera Gutiérrez, Carmen, additional, Boix, Vicente, additional, Díez Martínez, Marcos, additional, Carreres Candela, Melissa, additional, Gómez-Ayerbe, Cristina, additional, Sánchez-Lora, Javier, additional, Velasco Garrido, José Luis, additional, López-Jodar, María, additional, Santos González, Jesús, additional, Ruiz Aragón, Jesús, additional, Virto Peña, Ianire, additional, Alende Castro, Vanessa, additional, Sande Llovo, Diana, additional, Vega Molpeceres, Sonia, additional, Pons Viñas, Estel, additional, del Río Pérez, Oscar, additional, Valero Rovira, Silvia, additional, Villar-García, Judit, additional, Gómez-Junyent, Joan, additional, Cánepa, María Cecilia, additional, Castañeda Espinosa, Silvia, additional, Letang, Emilio, additional, Arenas-Miras, María del Mar, additional, Gómez-Zorrilla, Silvia, additional, Sánchez Martínez, Francesca, additional, Lerma-Chippirraz, Elisabet, additional, García Vázquez, Elisa, additional, Moral Escudero, Encarnación, additional, Roura Piloto, Aychel Elena, additional, García Almodóvar, Esther, additional, Sáez Barberá, Carmen, additional, Karroud, Zineb, additional, Hernández Quero, José, additional, Vinuesa García, David, additional, García Fogeda, José Luis, additional, Peregrina, José Antonio, additional, Novella Mena, María, additional, Hernández Gutiérrez, Cristina, additional, Sanz Moreno, José, additional, Pérez Tanoira, Ramón, additional, Navarro López, Jorge, additional, Balsa Vázquez, Javier, additional, Gutiérrez García, Aida, additional, Arranz Caso, Alberto, additional, Cuadros González, Juan, additional, Álvarez de Mon Soto, Melchor, additional, Díaz De Brito Fernández, Vicente Ferrer, additional, Sanmarti Vilamala, Montserrat, additional, Gabarrell Pascuet, Aina, additional, Molina Morant, Daniel, additional, España Cueto, Sergio, additional, Cámara Fernández, Jonathan, additional, Sabater Gil, Albert, additional, Muñoz López, Laura, additional, Jorge García, Ruth, additional, Molina Torres, Nora, additional, Sempere Alcocer, Marco Antonio, additional, De Castro Vega, Francisco Javier, additional, De los Santos Gil, Ignacio, additional, García-Fraile, Lucio, additional, Sampedro Núñez, Miguel, additional, Barrios Blandino, Ana, additional, Rodríguez Franco, Carlos, additional, Useros Brañas, Daniel, additional, Villa Martí, Almudena, additional, Oliver Ortega, Javier, additional, Costanza Espiño Álvarez, Alexia, additional, Sanz Sanz, Jesús, additional, Rexach Fumaña, María, additional, Policarpo Torres, Guillem, additional, Ortega Montoliu, Meritxell, additional, Sala Jofre, Clara, additional, Casas Rodríguez, Susana, additional, Tortajada Alamilla, Cecilia, additional, Oltra, Carmina, additional, Masiá Canuto, Mar, additional, Gutiérrez Rodero, Félix, additional, Oltra Sempere, María Rosa, additional, Vela Berna, Sara, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, De la Vega, Alexandra, additional, Pérez Pinto, Sergio, additional, Hernández Machín, Pilar, additional, Alastrué Violeta, Alba, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Calvo, Jorge, additional, Gozalo, Mónica, additional, Mora Gómez, Francisco, additional, Milagro Beamonte, Ana, additional, Latorre-Millán, Miriam, additional, Rezusta López, Antonio, additional, Martínez Sapiña, Ana, additional, Meije, Yolanda, additional, Ribera Puig, Alba, additional, Ortega Enciso, Lucía, additional, Sanz Salvador, Xavier, additional, Losa García, Juan Emilio, additional, Velasco Arribas, María, additional, Pérez-Rodríguez, M. Teresa, additional, Pérez González, Alexandre, additional, Belhassen-García, Moncef, additional, Rodríguez-Alonso, Beatriz, additional, López-Bernus, Amparo, additional, Carbonell, Cristina, additional, Torres Perea, Rafael, additional, Cantón De Seoane, Juan, additional, Alonso, Blanca, additional, Kamal, Sara Lidia, additional, Cajuela, Lucía, additional, Roa, David, additional, Cervero, Miguel, additional, Oreja, Alberto, additional, Avilés, Juan Pablo, additional, Martín, Lidia, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Abadia Otero, Jésica, additional, Salillas Hernando, Juan, additional, Torres Sánchez del Arco, Robert, additional, Torralba González de Suso, Miguel, additional, Serrano Martínez, Alberto, additional, Gilaberte Reyzábal, Sergio, additional, Pacheco Martínez-Atienza, Marina, additional, Liébana Gómez, Mónica, additional, Fernández Rodríguez, Sara, additional, Varela Plaza, Álvaro, additional, Calvo Sánchez, Henar, additional, Martínez Martín, Patricia, additional, González- Ruano, Patricia, additional, Malmierca Corral, Eduardo, additional, Rábago Lorite, Isabel, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Sirisi, Merce, additional, Rojas, Richard, additional, Díaz de Tuesta del Arco, José Luis, additional, Figueroa Cerón, Ruth, additional, González Sarria, Ander, additional, Alemán Valls, Remedios, additional, Alonso Socas, María del Mar, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Riera Jaume, Melchor, additional, Vilchez, Helem Haydee, additional, Albertí, Francesc, additional, Cañabate, Ana Isabel, additional, Moreno Cuerda, Víctor J, additional, Álvarez Kaelis, Silvia, additional, Álvarez Zapatero, Beatriz, additional, García García, Alejandro, additional, Isaba Ares, Elena, additional, Morcate Fernández, Covadonga, additional, Pérez Rodríguez, Andrea, additional, Ramos Merino, Lucía, additional, Castelo Corral, Laura, additional, Rodríguez Mahía, María, additional, González Bardanca, Mónica, additional, Sánchez Vidal, Efrén, additional, Míguez Rey, Enrique, additional, Correa Ruiz, Ana, additional, García de Lomas Guerrero, José Mº, additional, Daniel López, Daniel, additional, Marinas, Rebeca, additional, Morando, Marta, additional, Gómez García, Lucía, additional, Boix Palop, Lucia, additional, Dietl Gómez-Luengo, Beatriz, additional, Pedrola Gorrea, Iris, additional, Blasco Claramunt, Amparo, additional, López Mestanza, Cristina, additional, Fraile Villarejo, Esther, additional, Jaén Sánchez, Nieves, additional, Orihuela Martín, Jorge, additional, Algado Rabasa, José Tomas, additional, Garijo Saiz, Ana María, additional, Amador Prous, Concepción, additional, Salavert Lletí, Miguel, additional, Hernández Belmonte, Adriana, additional, Martínez Goñi, Raquel, additional, Navarro Vilasaró, Marta, additional, Calzado Isbert, Sonia, additional, Cervantes García, Manuel, additional, Gomila Grange, Aina, additional, Gasch Blasi, Oriol, additional, Machado Sicilia, María Luisa, additional, Van den Eynde Otero, Eva, additional, Falgueras López, Luis, additional, Navarro Sáez, María del Carmen, additional, Martínez, Esteban, additional, Marcos, Mº Ángeles, additional, Mosquera, Mar, additional, Blanco, José Luis, additional, Laguno, Montserrat, additional, Rojas, Jhon, additional, González-Cordón, Ana, additional, Inciarte, Alexy, additional, Torres, Berta, additional, De la Mora, Lorena, additional, Soriano, Alex, additional, Martínez Macia, Olalla, additional, Pérez Doñate, Virginia, additional, Cabello Úbeda, Alfonso, additional, Carrasco Antón, Nerea, additional, Álvarez Álvarez, Beatriz, additional, Petkova Saiz, Elizabet, additional, Górgolas Hernández-Mora, Miguel, additional, Prieto Pérez, Laura, additional, Carrillo Acosta, Irene, additional, Heili Frades, Sara, additional, Villar Álvarez, Felipe, additional, Fernández Roblas, Ricardo, additional, Sánchez Pernaute, Olga, additional, Fernández Espinilla, Virginia, additional, Castrodeza Sanz, José Javier, additional, Dueñas Gutiérrez, Carlos Jesús, additional, González-Romo, Fernando, additional, Merino Amador, Paloma, additional, Rueda López, Alba, additional, Martínez Jordán, Jorge, additional, Medrano Pardo, Sara, additional, Díaz de la Torre, Irene, additional, Posada Franco, Yolanda, additional, Delgado-Iribarren, Alberto, additional, López-Contreras González, Joaquín, additional, Pascual Alonso, Pablo, additional, Pomar Solchaga, Virginia, additional, Rabella García, Nuria, additional, Benito Hernández, Natividad, additional, Domingo Pedrol, Pere, additional, Bonfill Cosp, Xavier, additional, Padrós Selma, Rafael, additional, Puig Campmany, Mireia, additional, Mancebo Cortés, Jordi, additional, Gurguí Ferrer, Mercè, additional, Íñigo Pestaña, Melania, additional, Pérez García, Alejandra, additional, Sorní Moreno, Patricia, additional, Izko Gartzia, Nora, additional, Membrillo de Novales, Francisco Javier, additional, Simón Sacristán, María, additional, Zamora Cintas, Maribel, additional, Martínez Martínez, Yolanda, additional, Estébanez Muñoz, Miriam, additional, Ramírez-Olivencia, Germán, additional, Herrero Mendoza, María Dolores, additional, De Dios García, Begoña, additional, Mata Forte, Tatiana, additional, Rodríguez Fernández, José María, additional, Sáez de Adana Arróniz, Ester, additional, Portu Zapirain, Joseba, additional, Gainzarain Arana, Juan Carlos, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Moran Rodríguez, Miguel Ángel, additional, Canut Blasco, Andrés, additional, Hernáez Crespo, Silvia, additional, Sanjosé Muñiz, Irene, additional, Molina Iturritza, Estíbaliz, additional, Ganchegui Aguirre, Maite, additional, Urrestarazu Larrañag, Miren, additional, De la Higuera Arranz, Carmen, additional, Álvarez Padín, Pilar, additional, Iglesias Llorente, Laura, additional, Román Bernal, Berta, additional, Sánchez Montalvá, Adrián, additional, Espinosa Pereiro, Juan, additional, Almirante, Benito, additional, Miarons, Marta, additional, Sellarés, Júlia, additional, Larrosa, María, additional, Villamarín, Miguel, additional, Fernández, Nuria, additional, Salvador, Fernando, additional, Bosch-Nicolau, Pau, additional, Pérez-Jorge Peremarch, Conchita, additional, Resino Foz, Elena, additional, Espigares Correa, Andrea, additional, Álvarez de Espejo Montiel, Teresa, additional, Navas Clemente, Iván, additional, Quijano Contreras, María Isabel, additional, Nieto Fernández del Campo, Luis Alberto, additional, Jiménez Álvarez, Guillermo, additional, Guillamón Sánchez, Mercedes, additional, García García, Josefina, additional, Muñoz Hornero, Constanza, additional, Cosmen Sánchez, Ana, additional, Mariño Callejo, Ana, additional, Valcarce Pardeiro, Nieves, additional, Smithson Amat, Alex, additional, Chico Chumillas, Cristina, additional, Sánchez Serrano, Adriana, additional, Piñar Cabezos, Diana, additional, Jiménez Martínez, Isabel, additional, Estrada Fernández, Guillermo, additional, Lorén Vargas, María, additional, Parra Arribas, Nuria, additional, Martínez Cilleros, Carmen, additional, Villasante de la Puente, Aránzazu, additional, García Delange, Teresa, additional, Ruiz Rodríguez, María José, additional, Robledo del Prado, Marta, additional, Abad Almendro, Juan Carlos, additional, Muñoz del Rey, José Román, additional, Jiménez Álvaro, Montaña, additional, Coy Coy, Javier, additional, Poquet Catala, Inmaculada, additional, Santos Peña, Marta, additional, Mora Delgado, Juan, additional, Manso Gómez, Tamara, additional, Rubio Obanos, Teresa, additional, Barbeito Castiñeiras, Gema, additional, Domínguez Santalla, María Jesús, additional, Mao Martín, Laura, additional, Adalid Moll, María, additional, Díaz Luperena, Javier, additional, Ruiz Grinspan, Martín Sebastián, additional, Barrós González, Raquel, additional, Herrera Pacheco, Lourdes, additional, Martínez Avilés, Rocío, additional, Rodrigo González, Sara, additional, Rodríguez Leal, Cristóbal Manuel, additional, Romay Lema, Eva María, additional, Suárez Gil, Roi, additional, Bustinduy Odriozola, Maria Jesús, additional, Marimón Ortiz de Zárate, José María, additional, Vidaur Tello, Loreto, additional, Kortajarena Urkola, Xabier, additional, Arriola Martínez, Paula, additional, Lartategi Iraurgi, Alazne, additional, Álvarez de Castro, Maria, additional, Martínez Mateu, Cintia María, additional, Rodríguez Gómez, Francisco, additional, Asschert Agüero, Isabel, additional, Chamarro Martí, Elena, additional, Franch Llasat, Diego, additional, Zakariya-Yousef Breval, Ismail, additional, Rico Rodríguez, Marta, additional, Martínez López, Belén, additional, García-López, María, additional, Fernández Cruz, Ana, additional, Calderón Parra, Jorge, additional, Ramos Martínez, Antonio, additional, Múñez Rubio, Elena, additional, Vázquez Comendador, José Manuel, additional, Diego Yagüe, Itziar, additional, Expósito Palomo, Esther, additional, Díaz de Santiago, Alberto, additional, De la Fuente Moral, Sara, additional, Pintos Pascual, Ilduara, additional, Álvarez Franco, Raquel, additional, Fernández de Orueta, Lucía, additional, Vates Gómez, Roberto, additional, Cardona Arias, Andrés Felipe, additional, Marguenda Contreras, Pablo, additional, Gaspar Alonso-Vega, Gabriel, additional, Aranda Rife, Elena María, additional, Martínez Cifre, Blanca, additional, Roger Zapata, Daniel, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Piñero, Iván, additional, Bahamonde Carrasco, Alberto, additional, Martínez Vidal, Ana, additional, Talavera García, Eva, additional, Mendoza Roy, Paula, additional, Urrutia Losada, Ainhoa, additional, Arteche Eguizabal, Lorea, additional, Delgado Sánchez, Elisabet, additional, Bañón Escandell, Sara, additional, Caro Bragado, Sarah, additional, Domínguez de Pablos, Gema, additional, Herrero Rodríguez, Carmen, additional, Liébana Martos, Carmen, additional, Force Sanmartín, Luis, additional, Aranega, Raquel, additional, Mera Fidalgo, Arantzazu, additional, Hortos Alsina, Miquel, additional, Merchante Gutiérrez, Nicolas, additional, León Jiménez, Eva María, additional, Del Pozo, José L, additional, Serralta Buades, Josefa, additional, Cabrera Tejada, Ginger Giorgiana, additional, Fernández-Ruiz, Mario, additional, Aguado, José María, additional, Maestro de la Calle, Guillermo, additional, Vizcarra, Pilar, additional, Rodriguez Dominguez, Mario José, additional, Gioia, Francesca, additional, Del Campo, Santos, additional, Cantón Moreno, Rafael, additional, Martín Dávila, Pilar, additional, Casado, José Luis, additional, Oteo Revuelta, José Antonio, additional, Santibáñez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Ruiz Martínez, Carlos, additional, Blanco Ramos, José Ramón, additional, Azcona Gutiérrez, José M., additional, García García, Concepción, additional, Alba Fernández, Jorge, additional, Ibarra Cucalón, Valvanera, additional, San Franco, Mercedes, additional, Metola Sacristán, Luis, additional, Meijide Míguez, Héctor, additional, Gredilla Zubiría, Íñigo, additional, Menéndez, Justo, additional, Villares Fernández, Paula, additional, Montes Andújar, Lara, additional, Navarro Batet, Álvaro, additional, Ferrer Santolaria, Anna, additional, Padilla Salazar, María de la Luz, additional, Abella Vázquez, Lucy, additional, Hayek Peraza, Marcelino, additional, García Pardo, Antonio, additional, Hernández Carballo, Carolina, additional, Ruiz Fernández, Andrés Javier, additional, Barrio López, Isabel, additional, Martakoush, Alí, additional, Rojas-Vieyra, Agustín, additional, García Calvo, Sonia, additional, Villarreal García-Lomas, Mercedes, additional, Vizcaíno Callejón, Marta, additional, García García, María Pilar, additional, Lérida Urteaga, Ana, additional, Carrasco Fons, Natalia, additional, María Sanjuan, Beatriz, additional, Martín González, Lydia, additional, Sanz Zamudio, Camilo, additional, Alejos, Belén, additional, Moreno, Cristina, additional, Rava, Marta, additional, Iniesta, Carlos, additional, Izquierdo, Rebeca, additional, Suárez-García, Inés, additional, Díaz, Asunción, additional, Ruiz-Alguero, Marta, additional, Hernando, Victoria, additional, Frías, Jesús, additional, Ramírez, Elena, additional, Martín-Quirós, Alejandro, additional, Quintana-Díaz, Manuel, additional, Mingorance, Jesús, additional, Arnalich, Francisco, additional, Moreno, Francisco, additional, Figueiras, Juan Carlos, additional, García-Arenzana, Nicolás, additional, Montero-Vega, María Dolores, additional, Romero-Gómez, María Pilar, additional, Toro-Rueda, Carlos, additional, García-Bujalance, Silvia, additional, Ruiz-Carrascosa, Guillermo, additional, Cendejas-Bueno, Emilio, additional, Falces-Romero, Iker, additional, Lázaro-Perona, Fernando, additional, Ruiz-Bastián, Mario, additional, Gutiérrez-Arroyo, Almudena, additional, Girón De Velasco-Sada, Patricia, additional, Dahdouh, Elie, additional, Gómez-Arroyo, Bartolomé, additional, García-Sánchez, Consuelo, additional, Guedez-López, Virginia, additional, Bloise-Sánchez, Iván, additional, Alguacil-Guillén, Marina, additional, Liras-Hernández, Maria Gracia, additional, Sánchez-Castellano, Miguel Angel, additional, García-Clemente, Paloma, additional, González-Donapetry, Patricia, additional, San José-Villar, S, additional, de Pablos-Gómez,, Manuela, additional, Gómez-Gil, Rosa, additional, Corcuera-Pindado, Maria Teresa, additional, Rico-Nieto, Alicia, additional, Herrero, Alicia, additional, Prieto-Arribas, Daniel, additional, Oliver-Saez, Paloma, additional, Mora-Corcovado, Roberto, additional, Fernández-Calle, Pilar, additional, Alcaide-Martín, María José, additional, Díaz-Garzón, Jorge, additional, Fernández-Puntero, Belén, additional, Nuñez-Cabetas, Rocío, additional, Crespo-Sánchez, Gema, additional, Rodriguez-Fraga, Olaia, additional, Mendez del Sol, Helena, additional, Duque-Alcorta, Marta, additional, Gomez-Rioja, Rubén, additional, Sanz de Pedro, María, additional, Pascual-García, Lydia, additional, Segovia-Amaro, Marta, additional, Iturzaeta-Sánchez, Jose Manuel, additional, Rodriguez-Gutiérrez, Mercedes, additional, Perez-Garcia Morillón, Amparo, additional, Martinez Gallego, Miguel Angel, additional, Fabre-Estremera, Blanca, additional, Martinez-Chavez, Estefanía, additional, Moreno-Parra, Isabel, additional, Rodriguez-Roca, Neila, additional, Ortiz-Sánchez, Daniel, additional, Simon-Velasco, Manuela, additional, Gabriela-Tomoiu, Ileana, additional, Pizarro-Sanchez, Cristina, additional, Montero-San Martín, Blanca, additional, Qasem-Moreno, Ana Laila, additional, Gómez-López, Marta, additional, Casares Guerrero, Ismael, additional, Buño-Soto, Antonio, additional, Martí de Gracia, Milagros, additional, Parra-Gordo, Luz, additional, Diez-Tascón, Aurea, additional, Ossaba-Vélez, Silvia, additional, Pinilla, Inmaculada, additional, Cuesta, Emilio, additional, Fernández-Velilla, María, additional, Torres, Maria Isabel, additional, Garzón, Gonzalo, additional, Pérez-Blanco, Verónica, additional, Quintás-Viqueira, Almudena, additional, San Juan, Isabel, additional, Cantero-Escribano, José Miguel, additional, Pérez-Romero, César, additional, Castro-Martínez, Mercedes, additional, Hernández-Rivas, Lucía, additional, Pedraz, Teresa, additional, Fernández-Bretón, Eva, additional, García-Vaz, Claudia, additional, Robustillo-Rodela, Ana, additional, Torres Santos-Olmo, Rosario María, additional, Rivera-Núñez, Angélica, additional, Fernández-Fernández, Ignacio, additional, Noguerol-Gutiérrez, Marina, additional, Martínez-Virto, Ana María, additional, González-Viñolis, Manuel, additional, Cabrera-Gamero, Regina, additional, Mayayo-Alvira, Rosa, additional, Marín-Baselga, Raquel, additional, Lo-Iacono García, Victoria, additional, Lerín-Baratas, Macarena, additional, Romero Gallego-Acho, Paloma, additional, Reche-Martínez, Begoña, additional, Tejada-Sorados, Renzo, additional, Rico-Briñas, Mikel, additional, Deza-Palacios, Ricardo, additional, Fabra-Cadenas, Sara, additional, Arroyo-Rico, Isabel, additional, Ben-Abdellah, Lubna Dani, additional, Labajo-Montero, Laura, additional, Soriano-Arroyo, Rubén, additional, López-Corcuer, Lorena, additional, Calvin-García, Elena, additional, Martínez-Álvarez, Susana, additional, López-Tappero Irazábal, Laura, additional, Pilares-Barco, Martín, additional, González-Peña, Olga, additional, Bejarano-Redondo, Guillermina, additional, Iglesias-Sigüenza, Alberto, additional, Tung-Chen, Yale, additional, Maroun Eid, Charbel, additional, Bravo-Lizcano, Ruth, additional, Silvestre-Niño, Miguel, additional, Perdomo-García, Frank, additional, Alonso-González, Berta, additional, Antón-Huguet, Berta, additional, Arenas-Berenguer, Isabel, additional, Cabré-Verdiell Surribas, Clara, additional, Marqués-González, Francisco, additional, Muñoz del Val, Elena, additional, Ángeles Molina, María, additional, Cancelliere-Fernández, Nataly, additional, Pastor-Yvorra, Sivia, additional, Frade-Pardo, Laura, additional, López-Arévalo, Paloma, additional, García, Isabel, additional, Fernández-Capitán, Carmen, additional, González-Garcia, Juan José, additional, Herrero, Juan, additional, Quesada Simón, María Angustias, additional, Robles Marhuenda, Angel, additional, Soto Abanedes, Clara, additional, Noblejas Mozo, Ana María, additional, Ramos, Juan Carlos, additional, Jaras Hernandez, María Jesús, additional, Martinez Robles, Elena, additional, Moreno Fernandez, Alberto, additional, Sanchez Purificación, Aquilino, additional, Martin Gutiérrez, Juan Carlos, additional, Martinez Hernández, Pedro Luis, additional, Sancho Bueso, Teresa, additional, Lorenzo Hernández, Alicia, additional, Gutierrez Sancerni, Belén, additional, Salgueiro, Giorgina, additional, Martin Carbonero, Luz, additional, Mostaza, Jose María, additional, Martinez-López, María Angeles, additional, Hontañón, Victor, additional, Menéndez, Araceli, additional, Alvarez Troncoso, Jorge, additional, Castellano, Arancha, additional, Marcelo-Calvo, Cristina, additional, Vives-Beltrán, Ivo, additional, Ramos Ruperto, Luis, additional, Daroca-Bengoa, Germán, additional, Arcos Rueda, María, additional, Vasquez-Manau, Julia, additional, Fernández Cidón, Pelayo, additional, Rosario Herrero Gil, Carmen, additional, Palmier Peláez, Esmeralda, additional, Untoria Tabares, Yeray, additional, Lahoz, Carlos, additional, Estirado, Eva, additional, Hernández, Clara, additional, Garcia-Iglesias, Francisca, additional, Monteoliva, Enrique, additional, Martínez, Mónica, additional, Vara, Marta, additional, González Alegre, Teresa, additional, Valencia, Maria Eulalia, additional, Moreno, Victoria, additional, Montes, Maria Luisa, additional, Alcolea-Batres, Sergio, additional, Cabanillas-Martín, Juan José, additional, Carpio-Segura, Carlos, additional, Casitas-Mateo, Raquel, additional, Fernández-Bujarrabal Villoslada, Jaime, additional, Fernández-Navarro, Isabel, additional, Fernández-Lahera, Juan, additional, García-Quero, Cristina, additional, Hidalgo-Sánchez, María, additional, Galera-Martínez, Raúl, additional, García-Río, Francisco, additional, Gómez-Carrera, Luis, additional, Gómez-Mendieta, María Antonia, additional, Mangas-Moro, Alberto, additional, Martínez-Cerón, Elisabet, additional, Martínez-Redondo, María, additional, Martínez-Abad, Yolanda, additional, Martínez-Verdasco, Antonio, additional, Plaza-Moreno, Cristina, additional, Quirós-Fernández, Sarai, additional, Romera-Cano, Delia, additional, Romero-Ribate, David, additional, Sánchez-Sánchez, Begoña, additional, Santiago-Recuerda, Ana, additional, Villasante, Carlos, additional, Zamarrón de Lucas, Ester, additional, Arnalich-Montiel, Victoria, additional, Mariscal-Aguilar, Pablo, additional, Falcone, Adalgisa, additional, Laorden-Escudero, Daniel, additional, Prados Sánchez, María Concepción, additional, Álvarez-Sala Walther, Rodolfo, additional, García, Andony, additional, Arévalo, Cristina, additional, Gutiérrez, Carola, additional, Yus, Santiago, additional, Asensio, Maria José, additional, Sánchez, Manolo, additional, Añón, Jose Manuel, additional, Manzanares, Jesús, additional, García de Lorenzo, Abelardo, additional, Perales, Eva, additional, Civantos, Belén, additional, Cachafeiro, Lucía, additional, Agrifoglio, Alexander, additional, Estébanez, Belén, additional, Flores, Eva, additional, Hernández, Mónica, additional, Millán, Pablo, additional, Rodríguez, Montserrat, additional, Nanwani, Kapil, additional, Arizcun, Beatriz, additional, Pérez-Costa, Elena, additional, Rodríguez-Álvarez, Diego, additional, Sánchez-Martín, María, additional, Quesada, Úrsula, additional, Román-Hernández, Carmen, additional, Dorao, Paloma, additional, Álvarez-Rojas, Elena, additional, Menéndez, Juan José, additional, Verdú, Cristina, additional, Gómez-Zamora, Ana, additional, Schüffelmann, Cristina, additional, Calderón-Llopis, Belén, additional, Laplaza-González, María, additional, Río-García, Miguel, additional, Amores-Hernández, Irene, additional, Rodríguez-Rubio, Miguel, additional, de la Oliva, Pedro, additional, Ruiz, Jose, additional, Rosillo, Sandra, additional, González, Oscar, additional, Iniesta, Angel, additional, Ponz, Ines, additional, Muñoz-Ramón, José María, additional, Hernández-Gancedo, María, additional, Uña Orejón, Carmen R., additional, Sanabria-Carretero, Pascual, additional, Moreno Gómez-Limón, Isidro, additional, Seiz-Martinez, Alverio, additional, Guasch-Arévalo, Emilia, additional, Martín-Carrasco, Cristina, additional, Alvar, Elena, additional, Serrá, Lucía, additional, Iannuccelli, Fabricio, additional, Latorre, Julieta, additional, Casares, Sandra, additional, Valbuena, Isabel, additional, Díaz Díez Picazo, Luis, additional, Rodríguez Roca, Cristina, additional, Cervera, Omar, additional, García de las Heras, Esteban, additional, Durán, Pilar, additional, Castro, Carmen, additional, Manrique de Lara, Carlos, additional, Veganzones, Javier, additional, López-Tofiño, Araceli, additional, Fernandez-Cerezo, Estefanía, additional, Zurita, Sergio, additional, López-Martinez, Mercedes, additional, Prim, Teresa, additional, Alvárez del Vayo, Julía, additional, Alcaraz, Gabriela, additional, Castro, Luis, additional, Yagüe, Julio, additional, Díaz-Carrasco, Sofía, additional, González-Pizarro, Patricio, additional, Montero, Ana, additional, Sagra, Francisco Javier, additional, Suárez, Alejandro, additional, Díez-Porres, Leyre, additional, Varela-Cerdeira, María, additional, Alonso-Babarro, Alberto, additional, Abellán Martínez, Francisco, additional, Alonso-Eiras, Jorge Ignacio, additional, Álvarez Brandt, Alejandra, additional, Archinà, Martina, additional, Arribas-Terradillos, Silvia, additional, Baselga-Puente, Trinidad, additional, Barco Núñez, Pilar, additional, Barrera-López, Natalia Guadalupe, additional, Barrera-López, Lorena, additional, Bartrina-Tarrio, Andres, additional, Bassani, Gemma, additional, Betancort de la Torre, Paula, additional, Blanco-Bartolomé, Irene, additional, Blasco-Andres, Celia, additional, Brieba-Plata, Lucía, additional, Cadenas-Gota, Fernando, additional, Carrera-Vázquez, Paloma, additional, Cascajares-Sanz, Carlota, additional, Catino, Arianna, additional, Cavallé-Pulla, Raquel, additional, Ceniza-Pena, Daniel, additional, Conde-Alonso, Ylenia María, additional, Currás-Sánchez, Laura, additional, Daltro-Lage, Marcelo, additional, Esteban-Romero, Ana, additional, Fernández Vidal, María Luisa, additional, Ferrer Ortiz, Inés, additional, de la Fuente Regaño, Lydia, additional, Galindo-Ballesteros, Pablo, additional, Garcia-Bellido Ruiz, Sara, additional, García-Mochales Fortún, Carlos, additional, Gómez-Ballesteros, Teresa, additional, Gómez-Domínguez, Cecilia, additional, González-Aguado, Nelsa, additional, González-García, Sofía, additional, Guisández Martín, Jorge, additional, Hernández-Liebo, Paula Alejandra, additional, Hernando Nieto, Raquel, additional, Llorente-Cortijo, Irene María, additional, Marín-García, Antonio, additional, López-Pirez, Pilar, additional, Mejuto-Illade, Lucía, additional, Palma, Marco, additional, Peña-Hidalgo, Adrian, additional, Platero-Dueñas, Lucía, additional, Pujol-Pocull, David, additional, Ramírez-Verdyguer, Miguel, additional, Redondo-Gutierrez, Marta, additional, Reinoso-Lozano, Francisco, additional, Rodríguez-Revillas, Ana, additional, Rodríguez Saenz de Urturi, Alejandro, additional, Romero-Imaz, Lucía, additional, Sánchez-Rico, Susana, additional, Sánchez-Santiuste, Mónica, additional, Serrano de la Fuente, Patricia, additional, Serrano-Martín, Henar, additional, Silva-Freire, Thamires, additional, Soria-Alcaide, Eva, additional, Suárez-Plaza, Andrés Enrique, additional, Tejero-Soriano, Beatriz, additional, Torrecillas-Mainez, Andrea, additional, Torres-Cortés, Javier, additional, Valentín-Pastrana Aguilar, María de las Mercedes, additional, Villanueva-Freije, Angélica, additional, Virgós-Varela, Marta, additional, Yagüe-Barrado, Marta, additional, Yustas-Benitez, Natalia, additional, Nuñez, María Concepción, additional, Montserrat, Jaime, additional, Queiruga, Javier, additional, Rodriguez-Mariblanca, Amelia, additional, Martínez de Soto, Lucía, additional, Urroz, Mikel, additional, Seco, Enrique, additional, Zubimendi, Mónica, additional, Stuart, Stephan, additional, Díaz, Lucía, additional, García, Irene, additional, García Morales, María Teresa, additional, Martín-Vega, Alberto, additional, Caro, Abel, additional, and Martínez-Alés, Gonzalo, additional

Published
2021
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32. Temporal Trends and Geographic Variability in the Prescription of Antiretroviral Treatments in People Living with HIV in Spain, 2004–2020.

Author

Ruiz-Algueró, Marta, Hernando, Victoria, Riero, María, Blanco Ramos, José Ramón, de Zarraga Fernández, Miguel Alberto, Galindo, Pepa, Pérez-González, Alexandre, Díaz, Asunción, Suárez-García, Inés, and Jarrín, Inma

Subjects
*HIV-positive persons, *ANTIRETROVIRAL agents, *MEDICAL prescriptions
Abstract

Background: The purpose of this study was to describe temporal trends in the use of antiretroviral therapy (ART) among people living with HIV (PLWHIV) from the cohort of the Spanish HIV/AIDS research network (CoRIS), 2004–2020. Methods: We described the yearly evolution of the proportion of patients receiving ART and the most frequently prescribed antiretroviral drugs among newly recruited treatment-naïve patients and among all patients with active follow-up. Results: Of 15,539 patients included, 14,618 (94.1%) started ART during their follow-up. Regarding initial regimens, the use of 2NRTI plus 1NNRTI (which were the most frequently prescribed until 2014) and 2NRTI plus 1bPI decreased after 2014, being gradually replaced by INI-based triple therapies. Since 2019, other regimens started to be prescribed, mainly dual therapies. TDF/FTC/EFV was the single-tablet regimen (STR) most frequently prescribed as initial ART until 2012, decreasing thereafter as TDF/FTC/RPV, TDF/FTC/EVG/COBI, and ABC/3TC/DTG became available. TAF/FTC/BIC accounted for 53.6% of initial prescriptions in 2020, followed by DTG/3TC (24%). The percentage of patients on ART increased from 45.7% in 2004 to 98.2% in 2020. Among all patients receiving ART, regimens based on 2NRTI plus 1INI increased from 0.1% in 2007 to 53.3% in 2020. During 2007–2015, most patients were receiving TDF/FTC/EFV, which was replaced after 2017 by ABC/3TC/DTG. In 2020, 13.0% of patients were receiving dual therapies. Conclusions: Robust real-world data on ART use in PLWHIV over more than 15 years show historical trends in prescriptions with an unprecedented visualization of the contemporary treatment patterns. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Past and future of HIV infection. A document based on expert opinion.

Author

Bouza, Emilio, Ramón Arribas, José, Alejos, Belén, Ignacio Bernardino, José, Coiras, Maye, Coll, Pep, Del Romero, Jorge, Fuster, María José, Górgolas, Miguel, Gutiérrez, Alipio, Gracia, Diego, Hernando, Victoria, Martínez-Picado, Javier, Martínez Sesmero, José Manuel, Martínez, Esteban, Moreno, Santiago, Mothe, Beatriz, Navarro, Maria Luisa, Podzamczer, Daniel, and Pulido, Federico

Subjects
HIV infections, CHRONIC diseases, DISASTERS, LETHAL mutations, DISEASES
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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36. Vigilancia epidemiológica de la infección por el VIH: situación en la Unión Europea y en España, 2018

Author

Hernando, Victoria, Centro Nacional de Epidemiología. Instituto de Salud Carlos III, Ruiz-Algueró, Marta, Díaz, Asunción, vigilancia del VIH/sida, Responsables autonómicos de, and Los responsables de los registros autonómicos de VIH/sida

Subjects
Infección por el VIH, sida, vigilancia epidemiológica
Abstract

[ES] A continuación se presentan los principales resultados de la vigilancia de la infección por el virus de la inmunodeficiencia humana (VIH) en los países de la Unión Europa/Área Económica Europa (UE/AEE) y España correspondientes al año 2018, así como las tendencias en España en el periodo 2009-2018. La tasa de nuevos diagnósticos de VIH en España en 2018 fue superior a la media de la UE/AEE (8,6/100.000 habitantes en España y 5,8 en la UE/AEE, corregidas por retraso en la notificación), aunque es similar a la de otros países del entorno. La vía de transmisión más importante sigue siendo la sexual, ocupando el primer lugar las relaciones sexuales no protegidas entre hombres. Los datos muestran, tanto en España como en la UE/AEE, que casi la mitad de los nuevos diagnósticos en 2018 fueron tardíos y la tendencia se mantiene estable en los últimos años. El grupo de edad más afectado son los adultos entre 25 y 39 años. La tendencia de las tasas entre 2009 y 2018 es ligeramente descendente, variando según la categoría de transmisión. Entre personas que se inyectan drogas y los casos heterosexuales es decreciente. Por grupos de edad, la tendencia es descendente en todos ellos, excepto entre 25 y 29 años que se mantiene estable. [EN] This report shows the main results about HIV surveillance in European Union/European Economic Area (EU/EEA) and Spain in 2018, and the trends in Spain in the period 2009-2018. The rate of new HIV diagnoses in Spain was higher than the average in UE/EEA (8.6/100.000 population in Spain and 5.8 in EU/EEA, adjusting for report delay), although is similar to other neighbor countries. Sexual transmission is still the most important route of transmission, and the unprotected sexual relationships between men were the highest proportion of cases. In Spain, as well as EU/EEA countries, nearly half of new HIV diagnosed in 2018 were late presenters and the trend remains stable. Adults aged between 25 and 39 years were the largest age group. The rate trend is slightly decreased during the period 2009-2018, changing by category of transmission. Among persons who injecting drugs and heterosexuals, the trend is descending. By age group, the trend is descending, except between 25 and 29 that remains stable.

Published
2020

37. Progress towards the 90-90-90 HIV targets in 11 EU countries

Author

Vourli, Georgia, Noori, Teymur, Porter, Kholoud, Begovac, Josip, Delpech, Valerie, Girardi, Enrico, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Obel, Niels, Van Sighem, Ard, Sönnerborg, Anders, Supervie, Virginie, Zangerle, Robert, and Touloumi, Giota

Subjects
Antiretroviral treatment (ART), HIV, care, EU
Abstract

Despite the availability of highly effective antiretroviral treatment (ART), delayed diagnosis and ART initiation, and poor retention in care remain barriers to reducing HIV incidence. We aimed to estimate progress towards the UNAIDS 90- 90-90 targets by constructing the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. Using surveillance and cohort data from Austria, Croatia, Denmark, Germany, Greece, France, Italy, the Netherlands, Spain, Sweden and the United Kingdom, a CoC was constructed with four stages: i) number of people living with HIV (PLHIV) ; ii) proportion of PLHIV ever diagnosed ; iii) proportion of diagnosed who initiated ART ; iv) proportion of treated who achieved viral suppression (≤200 copies/mL) at their last visit (July 2015- December 2016). The 11 countries represent 73% of EU population and 85% of PLHIV in the region. The estimated number of PLHIV in the participating countries at the end of 2016 was 702, 848, corresponding to 0.19% adult prevalence. Overall, we estimated that 87% of PLHIV were diagnosed ; 92% of those diagnosed had initiated ART ; and 91% of those on ART were virally suppressed. Therefore, among all PLHIV 73% were virally suppressed. The corresponding figures for men having sex with men (MSM) were: 86%, 93%, 93% (and among all PLHIV 74%) ; for people who inject drugs (PWID): 91%, 88%, 84% (67%) ; for heterosexuals: 86%, 92%, 91% (72%) ; for men: 87%, 92%, 91% (73%) and for women: 89%, 92%, 89% (73%). Substantial variation across countries was observed. The EU is near to reaching the 90-90-90 UNAIDS targets, and achieved the UNAIDS final target of 73% of all PLHIV with viral suppression. This finding represents a significant progress compared to 2013, where 60% of all PLHIV were virally suppressed. However, differences between countries and key populations persisted in 2016. To improve outcomes along the CoCs, annual numbers of newly- acquired HIV infections and time intervals spent between stages need to be reduced. Furthermore, strengthening of testing programs and stronger treatment and adherence support, along with HIV prevention measures, are needed to achieve HIV epidemic control and, ultimately, AIDS elimination by 2030.

Published
2020

40. Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV

Author

Castilla, Jesus, Romero, Jorge del, Hernando, Victoria, Marincovich, Beatriz, Garcia, Soledad, and Rodriguez, Carmen

Subjects
Highly active antiretroviral therapy -- Dosage and administration, Heterosexuals -- Health aspects, HIV infection -- Prevention, Health
Abstract

HIV prevalence was compared among those who were recruited during the years before the introduction of highly active antiretroviral therapy (HAART) and those included during the period when HAART was being used. An important decrease in HIV transmission was observed in a thoroughly studied group of steady heterosexual couples, after the introduction of HAART, irrespective of any changes in other factors that affect transmission.

Published
2005

41. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Author

Berenguer, Juan, primary, Ryan, Pablo, additional, Rodríguez-Baño, Jesús, additional, Jarrín, Inmaculada, additional, Carratalà, Jordi, additional, Pachón, Jerónimo, additional, Yllescas, María, additional, Arriba, José Ramón, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, López, Juan Carlos, additional, Ramírez-Schacke, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Parras, Francisco, additional, Catalán, Pilar, additional, García-Leoni, María E., additional, Pérez-Tamayo, Isabel, additional, Puente, Luis, additional, Cedeño, Jamil, additional, Berenguer, Juan, additional, Díaz Menéndez, Marta, additional, de la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, Lago Núñez, Mª del Mar, additional, de Miguel Buckley, Rosa, additional, Cadiñaños Loidi, Julen, additional, Busca Arenzana, Carmen, additional, Mican, Alfredo, additional, Mora Rillo, Marta, additional, Ramos Ramos, Juan Carlos, additional, Loeches Yagüe, Belén, additional, Bernardino de la Serna, José Ignacio, additional, García Rodríguez, Julio, additional, Arribas López, José Ramón, additional, Such Diaz, Ana, additional, Álvaro Alonso, Elena, additional, Izquierdo García, Elsa, additional, Torres Macho, Juan, additional, Cuevas Tascon, Guillermo, additional, Troya García, Jesús, additional, Mestre Gómez, Beatriz, additional, Jiménez González de Buitrago, Eva, additional, Fernández Jiménez, Inés, additional, Tebar Martínez, Ana Josefa, additional, Brañas Baztán, Fátima, additional, Valencia de la Rosa, Jorge, additional, Pérez Butragueño, Mario, additional, Alvarado Blasco, Marta, additional, Sepúlveda Berrocal, Mª Antonia, additional, Yera Bergua, Carmen, additional, Toledano Sierra, Pilar, additional, Cano Llorente, Verónica, additional, Zafar Iqubal-Mirza, Sadaf, additional, Muñiz, Gema, additional, Martín Pérez, Inmaculada, additional, Mozas Moriñigo, Helena, additional, Alguacil, Ana, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Goikoetxea Agirre, Josune, additional, Blanco Vidal, María José, additional, Nieto Arana, Javier, additional, del Álamo Martínez de Lagos, Mikel, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Silvariño Fernández, Rafael, additional, Ugalde Espiñeira, Jon, additional, Asensi Álvarez, Víctor, additional, Suárez Pérez, Lucia, additional, Suárez Diaz, Silvia, additional, Yllera Gutiérrez, Carmen, additional, Boix, Vicente, additional, Díez Martínez, Marcos, additional, Carreres Candela, Melissa, additional, Gómez-Ayerbe, Cristina, additional, Sánchez-Lora, Javier, additional, Velasco Garrido, José Luis, additional, López-Jódar, María, additional, Santos González, Jesús, additional, Ruiz Aragón, Jesús, additional, Virto Peña, Ianire, additional, Alende Castro, Vanessa, additional, Brea Aparicio, Ruth, additional, Vega Molpeceres, Sonia, additional, Pons Viñas, Estel, additional, del Río Pérez, Oscar, additional, Valero Rovira, Silvia, additional, Villar-García, Judit, additional, Gómez-Junyent, Joan, additional, Knobel, Hernando, additional, Cánepa, María Cecilia, additional, Castañeda Espinosa, Silvia, additional, Sorli Redò, Luisa, additional, Güerri-Fernández, Roberto, additional, Milagro Montero, María, additional, Horcajada, Juan Pablo, additional, García Vázquez, Elisa, additional, Moral Escudero, Encarnación, additional, Hernández Torres, Alicia, additional, García Almodóvar, Esther, additional, Sáez Barberá, Carmen, additional, Karroud, Zineb, additional, Hernández Quero, José, additional, Vinuesa García, David, additional, García Fogeda, José Luis, additional, Peregrina, José Antonio, additional, Novella Mena, María, additional, Hernández Gutiérrez, Cristina, additional, Sanz Moreno, José, additional, Pérez Tanoira, Ramón, additional, Sierra Rodríguez, Rodrigo, additional, Alonso Menchén, David, additional, Gutiérrez García, Aida, additional, Arranz Caso, Alberto, additional, Cuadros González, Juan, additional, Álvarez de Mon Soto, Melchor, additional, Díaz de Brito Fernández, Vicente Ferrer, additional, Sanmarti Vilamala, Montserrat, additional, Gabarrell Pascuet, Aina, additional, Molina Morant, Daniel, additional, España Cueto, Sergio, additional, Cámara Fernández, Jonathan, additional, Sabater Gil, Albert, additional, Muñoz López, Laura, additional, Sáez Escolano, Paula, additional, Bejarano Tello, Esperanza, additional, Sempere Alcocer, Marco Antonio, additional, Álvarez Martin, Salvador, additional, De los Santos Gil, Ignacio, additional, García-Fraile, Lucio, additional, Sampedro Núñez, Miguel, additional, Barrios Blandino, Ana, additional, Rodríguez Franco, Carlos, additional, Useros Brañas, Daniel, additional, Villa Martí, Almudena, additional, Oliver Ortega, Javier, additional, Costanza Espiño Álvarez, Alexia, additional, Sanz Sanz, Jesús, additional, Rexach Fumaña, María, additional, Abascal Cambras, Ivette, additional, Pérez Jaén, Ana del Cielo, additional, Sala Jofre, Clara, additional, Casas Rodríguez, Susana, additional, Tortajada Alamilla, Cecilia, additional, Oltra, Carmina, additional, Masiá Canuto, Mar, additional, Gutiérrez Rodero, Félix, additional, Ferrer Ribera, Ana, additional, Bea Serrano, Carlos, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, Fiorante, Silvana, additional, Pérez Pinto, Sergio, additional, Hernández Machín, Pilar, additional, Alastrué Violeta, Alba, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Calvo, Jorge, additional, Gozalo, Mónica, additional, Mora Gómez, Francisco, additional, Milagro Beamonte, Ana, additional, Latorre-Millán, Miriam, additional, Rezusta López, Antonio, additional, Martínez Sapiña, Ana, additional, Meije, Yolanda, additional, Duarte Borges, Alejandra, additional, Pareja Coca, Julia, additional, Clemente Presas, Mercedes, additional, Losa García, Juan Emilio, additional, Vegas Serrano, Ana, additional, Pérez-Rodríguez, M. Teresa, additional, Pérez González, Alexandre, additional, Belhassen-García, Moncef, additional, Rodríguez-Alonso, Beatriz, additional, López-Bernus, Amparo, additional, Carbonell, Cristina, additional, Torres Perea, Rafael, additional, Cantón de Seoane, Juan, additional, Alonso, Blanca, additional, Kamal, Sara Lidia, additional, Cajuela, Lucia, additional, Roa, David, additional, Cervero, Miguel, additional, Oreja, Alberto, additional, Avilés, Juan Pablo, additional, Martín, Lidia, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Abadia Otero, Jessica, additional, Salillas Hernando, Juan, additional, Torres Sánchez del Arco, Robert, additional, Torralba González de Suso, Miguel, additional, Serrano Martínez, Alberto, additional, Gilaberte Reyzábal, Sergio, additional, Pacheco Martínez-Atienza, Marina, additional, Liébana Gómez, Mónica, additional, Fernández Rodríguez, Sara, additional, Varela Plaza, Álvaro, additional, Calvo Sánchez, Henar, additional, Martínez Martín, Patricia, additional, González- Ruano, Patricia, additional, Malmierca Corral, Eduardo, additional, Rábago Lorite, Isabel, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Sirisi, Merce, additional, Rojas, Richard, additional, Díaz de Tuesta del Arco, José Luis, additional, Figueroa Cerón, Ruth, additional, González Sarria, Ander, additional, Alemán Valls, Remedios, additional, Alonso Socas, María del Mar, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Riera Jaume, Melchor, additional, Vilchez, Helem Haydee, additional, Albertí, Francesc, additional, Cañabate, Ana Isabel, additional, Moreno Cuerda, Víctor J., additional, Álvarez Kaelis, Silvia, additional, Álvarez Zapatero, Beatriz, additional, García García, Alejandro, additional, Isaba Ares, Elena, additional, Morcate Fernández, Covadonga, additional, Pérez Rodríguez, Andrea, additional, Ramos Merino, Lucía, additional, Castelo Corral, Laura, additional, Rodríguez Mahía, María, additional, González Bardanca, Mónica, additional, Sánchez Vidal, Efrén, additional, Míguez Rey, Enrique, additional, De la Torre Lima, Javier, additional, García de Lomas Guerrero, José Mª, additional, Morte, Elena, additional, Loscos, Silvia, additional, Camón, Ana, additional, Gómez García, Lucía, additional, Boix Palop, Lucia, additional, Dietl Gómez-Luengo, Beatriz, additional, Pedrola Gorrea, Iris, additional, Blasco Claramunt, Amparo, additional, López Mestanza, Cristina, additional, Fraile Villarejo, Esther, additional, Tosco Núñez, Tomás, additional, Aroca Ferri, María, additional, Algado Rabasa, José Tomas, additional, Garijo Saiz, Ana María, additional, Amador Prous, Concepción, additional, Baño, Jesús Rodriguez, additional, Retamar, Pilar, additional, Valiente, Adoración, additional, López-Cortés, Luis E., additional, Sojo, Jesús, additional, Gutiérrez-Gutiérrez, Belén, additional, Bravo-Ferrer, José, additional, Salamanca, Elena, additional, Palacios, Zaira R., additional, Pérez-Palacios, Patricia, additional, Peral, Enrique, additional, Pérez de León, José Antonio, additional, Sánchez-Gómez, Jesús, additional, Marín-Barrera, Lucía, additional, García-Jiménez, Domingo, additional, Abelenda-Alonso, Gabriela, additional, Ardanuy, Carmen, additional, Bergas, Alba, additional, Cuervo, Guillermo, additional, Domínguez, María Ángeles, additional, Fernández-Huerta, Miguel, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Pérez-Recio, Sandra, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Trullen, Núria, additional, Salavert Lletí, Miguel, additional, Castro Hernández, Iván, additional, Hernández Belmonte, Adriana, additional, Martínez Goñi, Raquel, additional, Navarro Vilasaró, Marta, additional, Calzado Isbert, Sonia, additional, Cervantes García, Manuel, additional, Gomila Grange, Aina, additional, Gasch Blasi, Oriol, additional, Machado Sicilia, María Luisa, additional, Van den Eynde Otero, Eva, additional, Falgueras López, Luis, additional, Navarro Sáez, María del Carmen, additional, Martínez, Esteban, additional, Marcos, Mª Ángeles, additional, Mosquera, Mar, additional, Blanco, José Luis, additional, Laguno, Montserrat, additional, Rojas, Jhon, additional, González-Cordón, Ana, additional, Inciarte, Alexy, additional, Torres, Berta, additional, De la Mora, Lorena, additional, Soriano, Alex, additional, Martínez Macias, Olalla, additional, Pérez Doñate, Virginia, additional, Cabello Úbeda, Alfonso, additional, Carrasco Antón, Nerea, additional, Álvarez Álvarez, Beatriz, additional, Petkova Saiz, Elizabet, additional, Górgolas Hernández-Mora, Miguel, additional, Prieto Pérez, Laura, additional, Carrillo Acosta, Irene, additional, Heili Frades, Sara, additional, Villar Álvarez, Felipe, additional, Fernández Roblas, Ricardo, additional, Milicua Muñoz, José María, additional, Fernández Espinilla, Virginia, additional, Dueñas Gutiérrez, Carlos Jesús, additional, Hernán García, Cristina, additional, González-Romo, Fernando, additional, Merino Amador, Paloma, additional, Rueda López, Alba, additional, Martínez Jordán, Jorge, additional, Medrano Pardo, Sara, additional, Díaz de la Torre, Irene, additional, Posada Franco, Yolanda, additional, Delgado-Iribarren, Alberto, additional, López-Contreras González, Joaquín, additional, Pascual Alonso, Pablo, additional, Pomar Solchaga, Virginia, additional, Rabella García, Nuria, additional, Benito Hernández, Natividad, additional, Domingo Pedrol, Pere, additional, Bonfill Cosp, Xavier, additional, Padrós Selma, Rafael, additional, Puig Campmany, Mireia, additional, Mancebo Cortés, Jordi, additional, Gurguí Ferrer, Mercè, additional, Íñigo Pestaña, Melania, additional, Pérez García, Alejandra, additional, Sorní Moreno, Patricia, additional, Izko Gartzia, Nora, additional, Membrillo de Novales, Francisco Javier, additional, Simón Sacristán, María, additional, Zamora Cintas, Maribel, additional, Martínez Martínez, Yolanda, additional, Fernández-González, Pablo, additional, Alcántara Nicolás, Francisco, additional, Aguirre Vila-Cora, Alejandro, additional, López Tizón, Elena, additional, Ramírez-Olivencia, Germán, additional, Estébanez Muñoz, Miriam, additional, Sáez de Adana Arróniz, Ester, additional, Portu Zapirain, Joseba, additional, Gainzarain Arana, Juan Carlos, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Moran Rodríguez, Miguel Ángel, additional, Canut Blasco, Andrés, additional, Hernáez Crespo, Silvia, additional, Balerdi Sarasola, Leire, additional, Morales García, Cristina, additional, Corral Saracho, Miguel, additional, Valcarce González, Zeltia, additional, Arenal Andrés, Noelia, additional, Rodríguez Tarazona, Raquel Elisa, additional, Iglesias Llorente, Laura, additional, Loureiro Rodríguez, Beatriz, additional, Sánchez Montalvá, Adrián, additional, Espinosa Pereiro, Juan, additional, Almirante, Benito, additional, Miarons, Marta, additional, Sellarés, Júlia, additional, Larrosa, María, additional, García, Sonia, additional, Marzo, Blanca, additional, Villamarín, Miguel, additional, Fernández, Nuria, additional, Pérez-Jorge Peremarch, Conchita, additional, Resino Foz, Elena, additional, Espigares Correa, Andrea, additional, Álvarez de Espejo Montiel, Teresa, additional, Navas Clemente, Iván, additional, Quijano Contreras, María Isabel, additional, Nieto Fernández del Campo, Luis Alberto, additional, Jiménez Álvarez, Guillermo, additional, Guillamón Sánchez, Mercedes, additional, García García, Josefina, additional, Muñoz Hornero, Constanza, additional, Mariño Callejo, Ana, additional, Valcarce Pardeiro, Nieves, additional, Smithson Amat, Alex, additional, Chico Chumillas, Cristina, additional, Sánchez Serrano, Adriana, additional, García Villalba, Eva Pilar, additional, Jiménez Martínez, Isabel, additional, Estrada Fernández, Guillermo, additional, Lorén Vargas, María, additional, Parra Arribas, Nuria, additional, Martínez Cilleros, Carmen, additional, Villasante de la Puente, Aránzazu, additional, García Delange, Teresa, additional, Ruiz Rodríguez, María José, additional, Robledo del Prado, Marta, additional, Abad Almendro, Juan Carlos, additional, Muñoz del Rey, José Román, additional, Jiménez Álvaro, Montaña, additional, Coy Coy, Javier, additional, Poquet Catala, Inmaculada, additional, Santos Peña, Marta, additional, Naranjo Velasco, Virginia, additional, Manso Gómez, Tamara, additional, Quilez Ágreda, Delia, additional, Barbeito Castiñeiras, Gema, additional, Domínguez Santalla, María Jesús, additional, Mao Martín, Laura, additional, Alonso Navarro, Rodrigo, additional, Ampuero Martinich, Jose David, additional, Barrós González, Raquel, additional, Galindo Martín, María Aránzazu, additional, Herrera Pacheco, Lourdes, additional, Martínez Avilés, Rocío, additional, Rodrigo González, Sara, additional, Rodríguez Leal, Cristóbal Manuel, additional, Romay Lema, Eva María, additional, Suárez Gil, Roi, additional, Ibarguren Pinilla, Maialen, additional, Marimón Ortiz de Zárate, José María, additional, Vidaur Tello, Loreto, additional, Kortajarena Urkola, Xabier, additional, García Gómez, Miriam, additional, Aranguren Arostegui, Asier, additional, Álvarez de Castro, Maria, additional, Martínez Mateu, Cintia María, additional, Rodríguez Gómez, Francisco, additional, Muñoz Beamud, Francisco, additional, Chamarro Martí, Elena, additional, Cardona Rivera, Merce, additional, Zakariya-Yousef Breval, Ismail, additional, Rico Rodríguez, Marta, additional, Llenas García, Jara, additional, Sánchez Arenas, Mª Carmen, additional, Fernández Cruz, Ana, additional, Calderón Parra, Jorge, additional, López Dosil, Marcos, additional, Ramos Martínez, Antonio, additional, Múñez Rubio, Elena, additional, Callejas Díaz, Alejandro, additional, Vázquez Comendador, José Manuel, additional, Diego Yagüe, Itziar, additional, Expósito Palomo, Esther, additional, Anel Pedroche, Jorge, additional, Álvarez Franco, Raquel, additional, Fernández de Orueta, Lucía, additional, Vates Gómez, Roberto, additional, Cardona Arias, Andrés Felipe, additional, Marguenda Contreras, Pablo, additional, Gaspar Alonso-Vega, Gabriel, additional, Aranda Rife, Elena María, additional, Martínez Cifre, Blanca, additional, Roger Zapata, Daniel, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Piñero, Iván, additional, Bahamonde Carrasco, Alberto, additional, Runza Buznego, Paula, additional, Talavera García, Eva, additional, Lamata Subero, Marta, additional, Urrutia Losada, Ainhoa, additional, Arteche Eguizabal, Lorea, additional, Delgado Sánchez, Elisabet, additional, Molina Peinado, Virginia, additional, Caro Bragado, Sarah, additional, Domínguez de Pablos, Gema, additional, Roldán Fontana, Carolina, additional, Herrero Rodríguez, Carmen, additional, Force Sanmartín, Luis, additional, Aranega, Raquel, additional, Mera Fidalgo, Arantzazu, additional, Toda Savall, María Roca, additional, Merchante Gutiérrez, Nicolas, additional, León Jiménez, Eva María, additional, Del Pozo, José Luís, additional, Serralta Buades, Josefa, additional, Cabrera Tejada, Ginger Giorgiana, additional, Fernández-Ruiz, Mario, additional, Aguado, José María, additional, Maestro de la Calle, Guillermo, additional, Cisneros, José Miguel, additional, Aguilar-Guisado, Manuela, additional, Aldabó, Teresa, additional, Avilés, María Dolores, additional, Bueno, Claudio, additional, Cordero-Matía, Elisa, additional, Escoresca, Ana, additional, Gálvez-Benítez, Lydia, additional, Infante, Carmen, additional, Martín, Guillermo, additional, Praena, Julia, additional, Roca, Cristina, additional, Salamanca, Celia, additional, Suárez-Benjumea, Alejandro, additional, Vizcarra, Pilar, additional, Quereda, Carmen, additional, Rodriguez Dominguez, Mario José, additional, Gioia, Francesca, additional, Norman, Francesca, additional, Del Campo, Santos, additional, Cantón Moreno, Rafael, additional, Oteo Revuelta José, Antonio, additional, Santibáñez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Ruiz Martínez, Carlos, additional, Blanco Ramos, José R., additional, Azcona Gutiérrez, José M., additional, García García, Concepción, additional, Alba Fernández, Jorge, additional, Ibarra Cucalón, Valvanera, additional, San Franco, Mercedes, additional, Metola Sacristán, Luis, additional, Meijide Míguez, Héctor, additional, Paulos Viñas, Silvia, additional, Menéndez, Justo, additional, Villares Fernández, Paula, additional, Montes Andújar, Lara, additional, Navarro Batet, Álvaro, additional, Ferrer Santolaria, Anna, additional, Padilla Salazar, María de la Luz, additional, Abella Vázquez, Lucy, additional, Hayek Peraza, Marcelino, additional, García Pardo, Antonio, additional, Hernández Carballo, Carolina, additional, Ruiz Fernández, Andrés Javier, additional, Barrio López, Isabel, additional, Martakoush, Alí, additional, Rojas-Vieyra, Agustín, additional, García Calvo, Sonia, additional, Villarreal García-Lomas, Mercedes, additional, Vizcaíno Callejón, Marta, additional, García García, María Pilar, additional, Lérida Urteaga, Ana, additional, Carrasco Fons, Natalia, additional, María Sanjuan, Beatriz, additional, Martín González, Lydia, additional, Sanz Zamudio, Camilo, additional, Alejos, Belén, additional, Moreno, Cristina, additional, Rava, Marta, additional, Iniesta, Carlos, additional, Izquierdo, Rebeca, additional, Suárez-García, Inés, additional, Díaz, Asunción, additional, Ruiz-Alguero, Marta, additional, and Hernando, Victoria, additional

Published
2020
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42. Self-rated health among people living with HIV in Spain in 2019: a cross-sectional study

Author

Ruiz-Algueró, Marta, primary, Hernando, Victoria, additional, Marcos, Henar, additional, Gutiérrez, Gonzalo, additional, Pérez-Elías, Maria Jesus, additional, de Quirós, Juan Carlos López-Bernaldo, additional, Pulido, Federico, additional, Górgolas, Miguel, additional, Sanz, Jesus, additional, Suarez-García, Inés, additional, Fernandez, Maria Teresa, additional, Losa, Juan Emilio, additional, Pérez, Jose Luis, additional, Ladrero, Maria Oliva, additional, Prieto, Miguel Angel, additional, González, Gustavo, additional, Izquierdo, Ana, additional, Viloria, Luis Javier, additional, López, Irene, additional, Martínez, Eva, additional, Castrillejo, Daniel, additional, Aranguren, Rosa, additional, Belmonte, Maria Antonia, additional, Aranda-García, IV, additional, Arraiza, Antonio, additional, Diaz, Asuncion, additional, and Group, the Hospital Survey Study, additional

Published
2020
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47. IL7RA rs6897932 Polymorphism Is Associated with Better CD4+ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy

Author

Resino, Salvador, Navarrete-Munoz, Maria A., Blanco, Julia, Pacheco, Yolanda M., Castro, Ivan, Berenguer, Juan, Santos, Jesus, Vera-Mendez, Francisco J., Gorgolas, Miguel, Angeles Jimenez-Sousa, M. A., Benito, Jose M., Rallon, Norma, Moreno, Santiago, Jarrin, Inma, Dalmau, David, Luisa Navarro, Maria, Isabel Gonzalez, Maria, Luis Blanco, Jose, Garcia, Federico, Rubio, Rafael, Antonio Iribarren, Jose, Gutierrez, Felix, Vidal, Francesc, Gonzalez, Juan, Alejos, Belen, Hernando, Victoria, Moreno, Cristina, Iniesta, Carlos, Garcia Sousa, Luis Miguel, Sanz Perez, Nieves, Angeles Munoz-Fernandez, M., Maria Garcia-Merino, Isabel, Consuegra Fernandez, Irene, Gomez Rico, Coral, Gallego de la Fuente, Jorge, Palau Concejo, Paula, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Giner, Livia, Gadea, Carmen, Portilla, Irene, Pampliega, Maria, Diez, Marcos, Carlos Rodriguez, Juan, Sanchez-Paya, Jose, Luis Gomez, Juan, Hernandez, Jehovana, Remedios Aleman, Maria, del Mar Alonso, Maria, Inmaculada Hernandez, Maria, Diaz-Flores, Felicitas, Garcia, Dacil, Pelazas, Ricardo, Lopez Lirola, Ana, Sanz Moreno, Jose, Arranz Caso, Alberto, Hernandez Gutierrez, Cristina, Novella Mena, Maria, Pulido, Federico, Bisbal, Otilia, Hernando, Asuncion, Dominguez, Lourdes, Crestelo, David Rial, Bermejo, Laura, Santacreu, Mireia, Arrizabalaga, Julio, Jose Aramburu, Maria, Camino, Xabier, Rodriguez-Arrondo, Francisco, Angel von Wichmann, Miguel, Pascual Tome, Lidia, Angel Goenaga, Miguel, Bustinduy, Ma Jesus, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Masia, Mar, Padilla, Sergio, Navarro, Andres, Montolio, Fernando, Robledano, Catalina, Gregori Colome, Joan, Adsuar, Araceli, Pascual, Rafael, Fernandez, Marta, Garcia, Elena, Alberto Garcia, Jose, Barber, Xavier, Lopez Bernaldo de Quiros, Juan Carlos, Gutierrez, Isabel, Ramirez, Margarita, Padilla, Belen, Gijon, Paloma, Aldamiz-Echevarria, Teresa, Tejerina, Francisco, Jose Parras, Francisco, Balsalobre, Pascual, Diez, Cristina, Perez Latorre, Leire, Peraire, Joaquin, Vilades, Consuelo, Veloso, Sergio, Vargas, Montserrat, Lopez-Dupla, Miguel, Olona, Montserrat, Rull, Anna, Rodriguez-Gallego, Esther, Alba, Veronica, Montero Alonso, Marta, Lopez Aldeguer, Jose, Blanes Julia, Marino, Tasias Pitarch, Maria, Castro Hernandez, Ivan, Calabuig Munoz, Eva, Cuellar Tovar, Sandra, Salavert Lleti, Miguel, Fernandez Navarro, Juan, Gonzalez-garcia, Juan, Arnalich, Francisco, Ramon Arribas, Jose, Bernardino de la Serna, Jose Ignacio, Miguel Castro, Juan, Escosa, Luis, Herranz, Pedro, Hontanon, Victor, Garcia-Bujalance, Silvia, Garcia Lopez-Hortelano, Milagros, Gonzalez-Baeza, Alicia, Luz Martin-Carbonero, Maria, Mayoral, Mario, Jose Mellado, Maria, Esteban Mican, Rafael, Montejano, Rocio, Luisa Montes, Maria, Moreno, Victoria, Perez-Valero, Ignacio, Rodes, Berta, Sainz, Talia, Sendagorta, Elena, Stella Alcariz, Natalia, Valencia, Eulalia, Ramon Blanco, Jose, Antonio Oteo, Jose, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Perez-Martinez, Laura, Jaen, Angels, Sanmarti, Montse, Cairo, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemi, Rivero, Maria, Reparaz, Jesus, Ruiz de Alda, Maria Gracia, de Leon Cano, Maria Teresa, Ruiz de Galarreta, Beatriz Pierola, Segura, Ferran, Jose Amengual, Maria, Navarro, Gemma, Sala, Montserrat, Cervantes, Manuel, Pineda, Valentin, Calzado, Sonia, Navarro, Marta, de los Santos, Ignacio, Sanz Sanz, Jesus, Salas Aparicio, Ana, Sarria Cepeda, Cristina, Garcia-Fraile Fraile, Lucio, Martin Gayo, Enrique, Luis Casado, Jose, Dronda, Fernando, Moreno, Ana, Perez Elias, Maria Jesus, Gomez Ayerbe, Cristina, Gutierrez, Carolina, Madrid, Nadia, del Campo Terron, Santos, Marti, Paloma, Ansa, Uxua, Serrano, Sergio, Jesus Vivancos, Maria, Bernal, Enrique, Cano, Alfredo, Alcaraz Garcia, Antonia, Bravo Urbieta, Joaquin, Munoz, Angeles, Jose Alcaraz, Maria, del Carmen Villalba, Maria, Hernandez, Jose, Pena, Alejandro, Munoz, Leopoldo, Casas, Paz, Alvarez, Marta, Chueca, Natalia, Vinuesa, David, Martinez-Montes, Clara, Del Romero, Jorge, Rodriguez, Carmen, Puerta, Teresa, Carlos Carrio, Juan, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Riera, Melchor, Penaranda, Maria, Leyes, Maria, Ribas, Ma Angels, Campins, Antoni A., Vidal, Carmen, Fanjul, Francisco, Murillas, Javier, Homar, Francisco, Gomez Ayerbe, Crisitina, Viciana, Isabel, Palacios, Rosario, Maria Gonzalez, Carmen, Viciana, Pompeyo, Espinosa, Nuria, Fernando Lopez-Cortes, Luis, Podzamczer, Daniel, Ferrer, Elena, Imaz, Arkaitz, Tiraboschi, Juan, Silva, Ana, Saumoy, Maria, Olalla, Julian, del Arco, Alfonso, de la Torre, Javier, Luis Prada, Jose, de Lomas Guerrero, Jose Maria Garcia, Perez Stachowski, Javier, Juan Martinez, Onofre, Jesus Vera, Francisco, Martinez, Lorena, Garcia, Josefina, Alcaraz, Begona, Jimeno, Amaya, Castro Iglesias, Angeles, Pernas Souto, Berta, Mena de Cea, Alvaro, Galera, Carlos, Albendin, Helena, Perez, Aurora, Iborra, Asuncion, Moreno, Antonio, Merlos, Maria Angustias, Vidal, Asuncion, Suarez-Garcia, Ines, Malmierca, Eduardo, Gonzalez-Ruano, Patricia, Martin Rodrigo, Dolores, Ruiz Seco, Ma Pilar, Omar Mohamed-Balghata, Mohamed, Gomez Vidal, Maria Amparo, Estrada Perez, Vicente, Tellez Molina, Maria Jesus, Vergas Garcia, Jorge, Perez-Somarriba Moreno, Juncal, Cabello, Alfonso, Alvarez, Beatriz, Prieto, Laura, Galindo Puerto, Maria Jose, Fernando Vilalta, Ramon, Ferrer Ribera, Ana, Rivero Roman, Antonio, Brieva Herrero, Maria Teresa, Rivero Juarez, Antonio, Lopez Lopez, Pedro, Machuca Sanchez, Isabel, Pena Martinez, Jose, Cervero Jimenez, Miguel, Torres Perea, Rafael, Jusdado Ruiz-Capillas, Juan Jose, Pineda, Juan A., CoRIS HIV Biobank Integrated Spani, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), European Commission, Resino, Salvador, Castro, Iván, Resino, Salvador [0000-0001-8783-0450], and Castro, Iván [0000-0001-9938-2122]

Subjects
Male, 0301 basic medicine, humanos, lcsh:QR1-502, HIV Infections, Biochemistry, Gastroenterology, lcsh:Microbiology, 0302 clinical medicine, Receptor subunit, Genotype, Hiv infected patients, Drug Interactions, 030212 general & internal medicine, mediana edad, Cd4 t cell, Brief Report, immune reconstitution, Middle Aged, adulto, IL7RA, antirretrovirales, interacciones farmacológicas, Anti-Retroviral Agents, Female, SNPs, Adult, Cart, medicine.medical_specialty, Single-nucleotide polymorphism, cART, Polymorphism, Single Nucleotide, 03 medical and health sciences, Internal medicine, Statistical significance, medicine, Humans, Molecular Biology, Receptors, Interleukin-7, business.industry, HIV, Antiretroviral therapy, CD4, CD4 Lymphocyte Count, recuento de linfocitos CD4, 030104 developmental biology, infecciones por VIH, genotipo, business
Abstract

This article belongs to the Section Molecular Medicine., Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count 20% and was in Hardy–Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini–Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells count, This study has been (partially) funded by grants RD12/0017/0031 and D16/0025/0013 to JMB, and RD12/0017/0024 and RD16CIII/0002/0002 to SR as part of the Health Research and Development Strategy, State Plan for Scientific and Technical Research and Innovation (2008–2011; 2013–2016) and co-financed by Institute of Health Carlos III, ISCIII—Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). MA Jiménez-Sousa is funded by project RD16CIII/0002/0002; MA Navarrete-Muñoz is co-funded by RD16/0025/0013 project and Intramural Research Scholarship from IIS-FJD. N Rallón is a Miguel Servet investigator from the ISCIII [grant number CP14/00198].

Published
2019

48. Análisis de la evolución de la hepatitis B aguda en España, 2008-2018

Author

Hernando, Victoria, Ruíz Alguero, Marta, and Díaz, Asunción

Subjects
Virus Hepatitis B, vigilancia, infección aguda, epidemiología
Abstract

[ES] La hepatitis B es una enfermedad vírica de distribución mundial. En 2016 la Organización Mundial de la Salud publicó su estrategia con el objetivo eliminar las hepatitis víricas como una amenaza para la salud pública en 2030. El objetivo de este estudio fue analizar la evolución de la hepatitis B aguda en España entre 2008-2018. Para ello se realizó un análisis descriptivo a partir de los casos de hepatitis B aguda notificados a la Red Nacional de Vigilancia Epidemiológica. Para valorar la tendencia de las tasas en el periodo se utilizó el programa Jointpoint Regression Program. Se incluyeron 7.278 casos de los que 6.657 (91,5%) eran confirmados. Las tasas descendieron de forma significativa desde 2,12 a 0,92 casos por 100.000 entre 2008 y 2018. La tasa en hombres fue más elevada que en mujeres en todo el periodo y en ambos sexos se observa una tendencia decreciente. La edad media al diagnóstico aumentó desde 39,4 a 47,4 años. Se observa un desplazamiento de las tasas hacía grupos de edad superiores en los últimos años analizados, tanto de forma global como por sexo. Por Comunidad Autónoma se observa una tendencia descendente significativa en las tasas en ocho de ellas. La tendencia descendente observada en el periodo es similar a la situación en la Unión Europea, así como la distribución y evolución por edad y sexo. La vigilancia de esta enfermedad es esencial para monitorizar los progresos hacia su eliminación. [EN] Hepatitis B infection is a worldwide viral disease. In 2016, the World Health Organization published a strategy towards its elimination as a public health threat in 2030. The objective of this study was to analyze the evolution of acute hepatitis B infection, in Spain between 2008 and 2018. A descriptive analysis was performed based on the cases of acute hepatitis B notified to the National Epidemiological Surveillance Network. Jointpoint Regression Program was used to evaluate trends in rates. Overall, 7,278 cases were included, 6,657 (91.5%) of those were confirmed. Rates dropped significantly from 2.12 to 0.92 cases per 100,000 between 2008 and 2018. The sex pattern shows a greater involvement of men, but a decreasing trend is observed for both sexes. Mean age at diagnosis increased from 39.4 to 47.4. There is a shift in rates towards higher age groups in recent years, globally and by sex. By autonomous regions, there is a significant downward trend in rates being statistically significant in eight of them. Downward trend observed in the period is similar to that described in other European countries, as well as the distribution by age and sex. Surveillance of this disease is essential in order to monitor progress towards its elimination.

Published
2019

49. Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?

Author

Nikolopoulos, Georgios, Vourli, Georgia, Pharris, Anastasia, Cazein, Francoise, Costagliola, Dominique, Dabis, Francois, Del Amo, Julia, Delpech, Valerie, Díaz, Asuncion, Girardi, Enrico, Gourlay, Annabelle, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Porter, Kholoud, Rosińska, Magdalena, Sabin, Caroline, Suligoi, Barbara, Supervie, Virginie, Wit, Ferdinand, Touloumi, Giota, National and Kapodistrian University of Athens (NKUA), European Centre for Disease Prevention and Control (ECDC), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto de Salud Carlos III [Madrid] (ISC), Public Health England [London], Istituto Nazionale di Malattie Infettive 'Lazzaro Spallanzani' (INMI), University College of London [London] (UCL), London School of Hygiene and Tropical Medicine (LSHTM), Robert Koch Institute [Berlin] (RKI), Open University of Cyprus, Istituto Superiore di Sanita [Rome], Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), Nikolopoulos, Georgios [0000-0002-3307-0246], Rosińska, Magdalena [0000-0002-6256-7809], and Vourli, Georgia [0000-0002-9727-2808]

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, representativeness, Immunology, Population, MEDLINE, cohorts, HIV Infections, Sampling Studies, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, Young adult, education, Aged, education.field_of_study, business.industry, Transmission (medicine), Public health, HIV, Middle Aged, 3. Good health, Europe, Epidemiology and Social: Concise Communications, 030104 developmental biology, Infectious Diseases, Epidemiological Monitoring, Cohort, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, surveillance, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography, Cohort study
Abstract

Supplemental Digital Content is available in the text, Objective: HIV cohorts are an important source of clinical data for informing public health policies and programmes. However, the generalizability of cohort findings to the wider population of people diagnosed with HIV in each country remains unclear. In this work, we assessed the representativeness of six large national HIV cohorts within Europe. Design and methods: Individual-level cohort data were provided from national cohorts in France, Germany, Greece, Italy, Spain and the United Kingdom. Analysis focused on new HIV diagnoses reported to The European Surveillance System (TESSy) during three time periods (2000–2004, 2005–2009 and 2010–2013), to allow for temporal changes. Cohort and TESSy records were matched and compared by age, sex, transmission mode, region of origin and CD4+ cell count at diagnosis. The probability of being included in each cohort given demographic characteristics was estimated and used to generate weights inversely proportional to the probability of being included. Results: Participating cohorts were generally representative of the national HIV-diagnosed population submitted to TESSy. However, people who inject drugs, those born in a country other than that reporting the data, those with low CD4+ cell counts at diagnosis, and those more than 55 years were generally underrepresented in the cohorts examined. Conclusion: These European cohorts capture a representative sample of the HIV-diagnosed populations in each country; however some groups may be underrepresented.

Published
2019

50. VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients

Author

Jimenez-Sousa, Maria A., Luis Jimenez, Jose, Fernandez-Rodriguez, Amanda, Brochado-Kith, Oscar, Maria Bellon, Jose, Gutierrez, Felix, Diez, Cristina, Bernal-Morell, Enrique, Viciana, Pompeyo, Munoz-Fernandez, Maria A., Resino, Salvador, Moreno, Santiago, del Amo, Julia, Dalmau, David, Luisa Navarro, Maria, Isabel Gonzalez, Maria, Luis Blanco, Jose, Garcia, Federico, Rubio, Rafael, Antonio Iribarren, Jose, Vidal, Francesc, Berenguer, Juan, Gonzalez, Juan, Del Amo, Julia, Jarrin, Inma, Alejos, Belen, Hernando, Victoria, Moreno, Cristina, Iniesta, Carlos, Garcia Sousa, Luis Miguel, Perez, Nieves Sanz, Angeles Munoz-Fernandez, M., Maria Garcia-Merino, Isabel, Consuegra Fernandez, Irene, Gomez Rico, Coral, Gallego de la Fuente, Jorge, Palau Concejo, Paula, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Giner, Livia, Gadea, Carmen, Portilla, Irene, Pampliega, Maria, Diez, Marcos, Carlos Rodriguez, Juan, Sanchez-Paya, Jose, Luis Gomez, Juan, Hernandez, Jehovana, Remedios Aleman, Maria, del Mar Alonso, Maria, Inmaculada Hernandez, Maria, Diaz-Flores, Felicitas, Garcia, Dacil, Pelazas, Ricardo, Lopez Lirola, Ana, Sanz Moreno, Jose, Arranz Caso, Alberto, Hernandez Gutierrez, Cristina, Novella Mena, Maria, Pulido, Federico, Bisbal, Otilia, Hernando, Asuncion, Dominguez, Lourdes, Rial Crestelo, David, Bermejo, Laura, Santacreu, Mireia, Arrizabalaga, Julio, Jose Aramburu, Maria, Camino, Xabier, Rodriguez-Arrondo, Francisco, Angel von Wichmann, Miguel, Pascual Tome, Lidia, Angel Goenaga, Miguel, Jesus Bustinduy, Ma, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Masia, Mar, Padilla, Sergio, Navarro, Andres, Montolio, Fernando, Robledano, Catalina, Gregori Colome, Joan, Adsuar, Araceli, Pascual, Rafael, Fernandez, Marta, Garcia, Elena, Alberto Garcia, Jose, Barber, Xavier, Bernaldo de Quiros, Juan Carlos Lopez, Gutierrez, Isabel, Ramirez, Margarita, Padilla, Belen, Gijon, Paloma, Aldamiz-Echevarria, Teresa, Tejerina, Francisco, Jose Parras, Francisco, Balsalobre, Pascual, Perez Latorre, Leire, Peraire, Joaquin, Vilades, Consuelo, Veloso, Sergio, Vargas, Montserrat, Lopez-Dupla, Miguel, Olona, Montserrat, Rull, Anna, Rodriguez-Gallego, Esther, Alba, Veronica, Montero Alonso, Marta, Lopez Aldeguer, Jose, Blanes Julia, Marino, Tasias Pitarch, Maria, Castro Hernandez, Ivan, Calabuig Munoz, Eva, Cuellar Tovar, Sandra, Salavert Lleti, Miguel, Fernandez Navarro, Juan, Gonzalez-garcia, Juan, Arnalich, Francisco, Ramon Arribas, Jose, Bernardino de la Serna, Jose Ignacio, Miguel Castro, Juan, Escosa, Luis, Herranz, Pedro, Hontanon, Victor, Garcia-Bujalance, Silvia, Garcia Lopez-Hortelano, Milagros, Gonzalez-Baeza, Alicia, Luz Martin-Carbonero, Maria, Mayoral, Mario, Jose Mellado, Maria, Esteban Mican, Rafael, Montejano, Rocio, Luisa Montes, Maria, Moreno, Victoria, Perez-Valero, Ignacio, Rodes, Berta, Sainz, Talia, Sendagorta, Elena, Stella Alcariz, Natalia, Valencia, Eulalia, Ramon Blanco, Jose, Antonio Oteo, Jose, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Perez-Martinez, Laura, Jaen, Angels, Sanmarti, Montse, Cairo, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemi, Rivero, Maria, Reparaz, Jesus, Ruiz de Alda, Maria Gracia, de Leon Cano, Maria Teresa, Ruiz de Galarreta, Beatriz Pierola, Segura, Ferran, Jose Amengual, Maria, Navarro, Gemma, Sala, Montserrat, Cervantes, Manuel, Pineda, Valentin, Calzado, Sonia, Navarro, Marta, de los Santos, Ignacio, Sanz Sanz, Jesus, Salas Aparicio, Ana, Sarria Cepeda, Cristina, Garcia-Fraile Fraile, Lucio, Martin Gayo, Enrique, Luis Casado, Jose, Dronda, Fernando, Moreno, Ana, Perez Elias, Maria Jesus, Gomez Ayerbe, Cristina, Gutierrez, Carolina, Madrid, Nadia, del Campo Terron, Santos, Marti, Paloma, Ansa, Uxua, Serrano, Sergio, Jesus Vivancos, Maria, Bernal, Enrique, Cano, Alfredo, Alcaraz Garcia, Antonia, Bravo Urbieta, Joaquin, Munoz, Angeles, Jose Alcaraz, Maria, del Carmen Villalba, Maria, Hernandez, Jose, Pena, Alejandro, Munoz, Leopoldo, Casas, Paz, Alvarez, Marta, Chueca, Natalia, Vinuesa, David, Martinez-Montes, Clara, Del Romero, Jorge, Rodriguez, Carmen, Puerta, Teresa, Carlos Carrio, Juan, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Riera, Melchor, Penaranda, Maria, Leyes, Maria, Angels Ribas, Ma, Campins, Antoni A., Vidal, Carmen, Fanjul, Francisco, Murillas, Javier, Homar, Francisco, Santos, Jesus, Gomez Ayerbe, Crisitina, Viciana, Isabel, Palacios, Rosario, Maria Gonzalez, Carmen, Espinosa, Nuria, Fernando Lopez-Cortes, Luis, Podzamczer, Daniel, Ferrer, Elena, Imaz, Arkaitz, Tiraboschi, Juan, Silva, Ana, Saumoy, Maria, Olalla, Julian, del Arco, Alfonso, de la Torre, Javier, Luis Prada, Jose, de Lomas Guerrero, Jose Maria Garcia, Perez Stachowski, Javier, Juan Martinez, Onofre, Jesus Vera, Francisco, Martinez, Lorena, Garcia, Josefina, Alcaraz, Begona, Jimeno, Amaya, Castro Iglesias, Angeles, Pernas Souto, Berta, Mena de Cea, Alvaro, Galera, Carlos, Albendin, Helena, Perez, Aurora, Iborra, Asuncion, Moreno, Antonio, Angustias Merlos, Maria, Vidal, Asuncion, Suarez-Garcia, Ines, Malmierca, Eduardo, Gonzalez-Ruano, Patricia, Martin Rodrigo, Dolores, Omar Mohamed-Balghata, Mohamed, Gomez Vidal, Maria Amparo, Estrada Perez, Vicente, Tellez Molina, Maria Jesus, Vergas Garcia, Jorge, Perez-Somarriba Moreno, Juncal, Gorgolas, Miguel, Cabello, Alfonso, Alvarez, Beatriz, Prieto, Laura, Galindo Puerto, Maria Jose, Fernando Vilalta, Ramon, Ferrer Ribera, Ana, Rivero Roman, Antonio, Brieva Herrero, Maria Teresa, Rivero Juarez, Antonio, Lopez Lopez, Pedro, Machuca Sanchez, Isabel, Pena Martinez, Jose, Cervero Jimenez, Miguel, Torres Perea, Rafael, Jusdado Ruiz-Capillas, Juan Jose, Pineda, Juan A., CoRIS, Spanish HIV HGM BioBank, LTNPs Cohort, Red de Investigación Cooperativa en Investigación en Sida (España), Instituto de Salud Carlos III, and Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)

Subjects
Oncology, medicine.medical_specialty, LTNPs, lcsh:Medicine, Single-nucleotide polymorphism, non-progression, 030312 virology, Calcitriol receptor, 03 medical and health sciences, single nucleotide polymorphisms, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Vitamin D and neurology, SNP, Allele, 030304 developmental biology, VDR, Non-progression, 0303 health sciences, business.industry, Brief Report, lcsh:R, General Medicine, Odds ratio, Single nucleotide polymorphisms, Acquired immune system, medicine.disease, AIDS, business
Abstract

Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes., This work has been (partially) funded by the RD16/0025/0019 and RD16CIII/0002/0002, projects as part of Accion Estrategica en Salud, Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (2013-2016) and cofinanced by Instituto de Salud Carlos III (Subdireccion General de Evaluacion) and Fondo Europeo de Desarrollo Regional (FEDER), RETIC PT17/0015/0042, Fondo de Investigacion Sanitaria (FIS) (grant number PI16/01863, PI17/01115, PI17CIII/00003), EPIICAL Project and Comunidad de Madrid B2017/BMD-3703. Programa de Investigacion de la Consejeria de Sanidad de la Comunidad de Madrid to JLJ. CIBER-BBN is an initiative funded by the VI National R& D& i Plan 2008-2011, Iniciativa Ingenio 2010, the Consolider Program, and CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. COST CA17140 Cancer Nanomedicine-Front the Bench to Bebside. AFR are supported and funded by Instituto de Salud Carlos III [grant number CP14/0010].

Published
2019

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