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Arrhythmogenic cardiomyopathy is an inherited entity characterized by irregular cell–cell adhesion, cardiomyocyte death and fibro-fatty replacement of ventricular myocytes, leading to malignant ventricular arrythmias, contractile dysfunction and sudden cardiac death. Pathogenic variants in genes that encode desmosome are the predominant cause of arrhythmogenic cardiomyopathy. Moreover, signalling pathways such as Wnt/ß-catenin and transforming growth factor-β have been involved in the disease progression. However, still little is known about the molecular pathophysiological mechanisms that underlie arrhythmogenic cardiomyopathy pathogenesis. We used mRNA and small RNA sequencing to analyse the transcriptome of health and arrhythmogenic cardiomyopathy of autopsied human hearts. Our results showed 697 differentially expressed genes and eight differentially expressed miRNAs. Functional enrichment revealed mitochondrial respiratory-related pathways, impaired response to oxidative stress, apoptotic signalling pathways and inflammatory response-related and extracellular matrix response pathways. Furthermore, analysis of the miRNA–mRNA interactome identified eleven negatively correlated miRNA-target pairs for arrhythmogenic cardiomyopathy. Our finding revealed novel arrhythmogenic cardiomyopathy-related miRNAs with important regulatory function in disease pathogenesis, highlighting their value as potential key targets for therapeutic approaches. [ABSTRACT FROM AUTHOR]

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Background: Pitx2 (paired-like homeodomain 2 transcription factor) is crucial for heart development, but its role in heart failure (HF) remains uncertain. The present study lays the groundwork implicating Pitx2 signalling in different modalities of HF. Methodology/Principal Findings: A variety of molecular, cell-based, biochemical, and immunochemical assays were used to evaluate: (1) Pitx2c expression in the porcine model of diastolic HF (DHF) and in patients with systolic HF (SHF) due to dilated and ischemic cardiomyopathy, and (2) molecular consequences of Pitx2c expression manipulation in cardiomyocytes in vitro. In pigs, the expression of Pitx2c, physiologically downregulated in the postnatal heart, is significantly re-activated in left ventricular (LV) failing myocardium which, in turn, is associated with increased expression of a restrictive set of Pitx2 target genes. Among these, Myf5 was identified as the top upregulated gene. In vitro, forced expression of Pitx2c in cardiomyocytes, but not in skeletal myoblasts, activates Myf5 in dose-dependent manner. In addition, we demonstrate that the level of Pitx2c is upregulated in the LV-myocardium of SHF patients. Conclusions/Significance: The results provide previously unrecognized evidence that Pitx2c is similarly reactivated in postnatal/adult heart at distinct HF phenotypes and suggest that Pitx2c is involved, directly or indirectly, in the regulation of Myf5 expression in cardiomyocytes. [ABSTRACT FROM AUTHOR]

Health systems look for a continuous improvement on quality with efficacy and efficiency to achieve ideal results in the attention to patients and to their families. However, there is an ample variation in the processes and results. An effective conceptual and methodological basis is proposed, focused on the patient as a product of a warm and technical attention with an appropriate management and application of resources that are defined as to give medical opportune attention to the patient with professional competency, safety and respect to the ethical principles of medical practice that allows to fulfil the patient's health necessities, its expectations and within a reasonable price. The efficacy is disintegrated to emphasise the result, the impact on the person's health and the positive modification on its well-being through a multilevel model that motivates the continuous improvement of the four-level quality: individual, microsystems, organizations and the national health system; and it also resumes the propel forces for its success: leadership, organized culture, microsystems development in high-performance equipment, and communication and information technologies. [ABSTRACT FROM AUTHOR]

Introduction. In Mexico there isn't enough updated information concerning Dentistry Professionals that indicates a broad panorama of the trade's situation. The purpose of the study is to offer a first approach to a wider and more precise vision of the situation of dentists in Mexico. Material and Methods. Analysis of documented revision, longitudinal, by decades of 1970 to 2012, from the following 5 perspectives: a) professional field: licensed professionals; b) geographic role: based on INEGI (National Institute of Statistics and Geography) reports; c) workplace: dentists that work in public and private health institutions, according to data provided by the Ministry of Health and Tax Administration Services (SAT); d) academic field: enrollments, study completions and graduates according to ANUIES (National Association of Universities and Higher Education Institutions) and the Ministry of Public Education; and e) international scope: according to the World Health Organization (WHO). Results. In 1970 a total of 10,345 licensed dentists were registered, while for 2010 there were 151,622 dentists organized in the following way: in Bachelor Studies 92.7% (140,548), in Specialties 6.5% (9,876), in Masters 0.75% (1,145), in PHD 0.035% (53). The entity with a greater number of dentists was Mexico City with 59,214 (39.05%), in contrast Baja California, Colima and Morelos that have 0 (cero), 24 (0.02%) and 48 (0.03%) dentists. In 1990 there were 25, 965 male dentists registered (44.5%) and 32,383 female (55.5%). In 1990, 4,267 dentists worked in public institutions, number that increased to 8,707 in 2010; in 2012 there were 64,408 dental clinics registered before the SAT. From the Bachelor's Degree there are 9 different classifications: 75.24% are graduated as dental surgeon; others are: dentistry, stomatology, medical doctor and dentist, dental military surgeon. In 2000, in the WHO there were 78,281 dentists registered, reaching a density of 8:10,000 inhabitants. Conclusions. This panorama allows us to have a broader and more precise perspective of the professional situation of the field in our country, for the development of strategies designed for the resolution of needs regarding Dental Health in our population. [ABSTRACT FROM AUTHOR]

Copyright of Revista CONAMED is the property of Comision Nacional de Arbitraje Medico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista CONAMED is the property of Comision Nacional de Arbitraje Medico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista CONAMED is the property of Comision Nacional de Arbitraje Medico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The organization, conceived as a living organism, requires different techniques to support the integration of diagnosis, prognosis and critical routes to help them survive in the context of health services provision. This fact is not unrelated in the public sector, provided that although a regulatory framework, defined powers and properly programmed budgets exist, it is still necessary to create strategic plans that help to define the vision, mission, goals and objectives required to meet users' expectations when public health services are required. These services must then be efficiently and effectively provided and offer optimal results for patients' recovery. Assessment tools allow to analyze, measure and improve the infrastructure and resources, both economic, technological and human resources that will be of vital importance in the daily activities of medical units, and to deal with deviations presented within the organization. Quality assessment is a valuable premise to observe if users' expectations have been met, or whether deviations may threaten the organization. This article proposes to carry out the evaluation of the quality of health services in three levels: general, services and individual, in order to analyze specific cases such as complaints and/or disagreements presented to administrative, civil or criminal authorities, towards the generation of information that may provide elements to the decision making process in benefit of medical services provision. [ABSTRACT FROM AUTHOR]

La literatura escrita acerca de la queja médica es relativamente escasa. En este artículo se pretende profundizar sobre las variables psicosociales que envuelven a la persona que es víctima de un acto médico deficiente, ya sea por omisión, negligencia, ignorancia o descuido. Así mismo, se trata de abordar cómo influyen variables como la personalidad del que se queja, sus reacciones emocionales con base en la magnitud del daño, cómo influye la relación médico-paciente en la percepción del daño y estilo de queja, cuándo y cómo la negligencia o el error dejan un trauma, cuál es la trascendencia de éste en la vida del que se queja y cómo un trauma psicológico puede influir en la calidad de vida y la productividad del paciente. También se aborda la importancia de la comunicación en la prevención de una queja médica y se trata de analizar cómo en una misma familia el acto médico y sus consecuencias, pueden ser percibidos de distinta forma. Se hace una descripción de la clasificación de los errores médicos bajo la óptica de la psicología del daño, en la cual se hace un propuesta de reclasificación, distinta a la propuesta por International Journal for Quality in Health Care. [ABSTRACT FROM AUTHOR]