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2. MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

Author

Sigaud, Romain, Albert, Thomas K., Hess, Caroline, Hielscher, Thomas, Winkler, Nadine, Kocher, Daniela, Walter, Carolin, Münter, Daniel, Selt, Florian, Usta, Diren, Ecker, Jonas, Brentrup, Angela, Hasselblatt, Martin, Thomas, Christian, Varghese, Julian, Capper, David, Thomale, Ulrich W., Hernáiz Driever, Pablo, Simon, Michèle, Horn, Svea, Herz, Nina Annika, Koch, Arend, Sahm, Felix, Hamelmann, Stefan, Faria-Andrade, Augusto, Jabado, Nada, Schuhmann, Martin U., Schouten-van Meeteren, Antoinette Y. N., Hoving, Eelco, Brummer, Tilman, van Tilburg, Cornelis M., Pfister, Stefan M., Witt, Olaf, Jones, David T. W., Kerl, Kornelius, and Milde, Till

Published
2023
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3. The Supraorbital Eyebrow Approach in Pediatric Neurosurgery: Perspectives and Challenges of Frontal Keyhole Surgery

Author

Sanchin, Aminaa, Bertelmann, Eckart, Hernáiz Driever, Pablo, Tietze, Anna, Thomale, Ulrich-Wilhelm, Di Rocco, Concezio, Series Editor, Arraez, Miguel A., Editorial Board Member, Boop, Frederick A., Editorial Board Member, Froelich, Sebastien, Editorial Board Member, Kato, Yoko, Editorial Board Member, Pang, Dachling, Editorial Board Member, and Tu, Yong-Kwang, Editorial Board Member

Published
2023
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4. Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2023
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6. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2024
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11. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Author

Waszak, Sebastian M, Northcott, Paul A, Buchhalter, Ivo, Robinson, Giles W, Sutter, Christian, Groebner, Susanne, Grund, Kerstin B, Brugières, Laurence, Jones, David TW, Pajtler, Kristian W, Morrissy, A Sorana, Kool, Marcel, Sturm, Dominik, Chavez, Lukas, Ernst, Aurelie, Brabetz, Sebastian, Hain, Michael, Zichner, Thomas, Segura-Wang, Maia, Weischenfeldt, Joachim, Rausch, Tobias, Mardin, Balca R, Zhou, Xin, Baciu, Cristina, Lawerenz, Christian, Chan, Jennifer A, Varlet, Pascale, Guerrini-Rousseau, Lea, Fults, Daniel W, Grajkowska, Wiesława, Hauser, Peter, Jabado, Nada, Ra, Young-Shin, Zitterbart, Karel, Shringarpure, Suyash S, De La Vega, Francisco M, Bustamante, Carlos D, Ng, Ho-Keung, Perry, Arie, MacDonald, Tobey J, Hernáiz Driever, Pablo, Bendel, Anne E, Bowers, Daniel C, McCowage, Geoffrey, Chintagumpala, Murali M, Cohn, Richard, Hassall, Timothy, Fleischhack, Gudrun, Eggen, Tone, Wesenberg, Finn, Feychting, Maria, Lannering, Birgitta, Schüz, Joachim, Johansen, Christoffer, Andersen, Tina V, Röösli, Martin, Kuehni, Claudia E, Grotzer, Michael, Kjaerheim, Kristina, Monoranu, Camelia M, Archer, Tenley C, Duke, Elizabeth, Pomeroy, Scott L, Shelagh, Redmond, Frank, Stephan, Sumerauer, David, Scheurlen, Wolfram, Ryzhova, Marina V, Milde, Till, Kratz, Christian P, Samuel, David, Zhang, Jinghui, Solomon, David A, Marra, Marco, Eils, Roland, Bartram, Claus R, von Hoff, Katja, Rutkowski, Stefan, Ramaswamy, Vijay, Gilbertson, Richard J, Korshunov, Andrey, Taylor, Michael D, Lichter, Peter, Malkin, David, Gajjar, Amar, Korbel, Jan O, and Pfister, Stefan M

Subjects
Humans, Medulloblastoma, Cerebellar Neoplasms, Genetic Predisposition to Disease, Risk Factors, Retrospective Studies, Prospective Studies, Reproducibility of Results, Predictive Value of Tests, Gene Expression Profiling, Pedigree, DNA Mutational Analysis, DNA Methylation, Heredity, Phenotype, Germ-Line Mutation, Models, Genetic, Adolescent, Adult, Child, Child, Preschool, Infant, Female, Male, Young Adult, Genetic Testing, Transcriptome, Biomarkers, Tumor, Progression-Free Survival, Exome Sequencing, Brain Cancer, Genetics, Cancer, Human Genome, Pediatric, Pediatric Cancer, Rare Diseases, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundMedulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and testing for paediatric patients are not available. We aimed to assess and define these genes to provide evidence for future screening guidelines.MethodsIn this international, multicentre study, we analysed patients with medulloblastoma from retrospective cohorts (International Cancer Genome Consortium [ICGC] PedBrain, Medulloblastoma Advanced Genomics International Consortium [MAGIC], and the CEFALO series) and from prospective cohorts from four clinical studies (SJMB03, SJMB12, SJYC07, and I-HIT-MED). Whole-genome sequences and exome sequences from blood and tumour samples were analysed for rare damaging germline mutations in cancer predisposition genes. DNA methylation profiling was done to determine consensus molecular subgroups: WNT (MBWNT), SHH (MBSHH), group 3 (MBGroup3), and group 4 (MBGroup4). Medulloblastoma predisposition genes were predicted on the basis of rare variant burden tests against controls without a cancer diagnosis from the Exome Aggregation Consortium (ExAC). Previously defined somatic mutational signatures were used to further classify medulloblastoma genomes into two groups, a clock-like group (signatures 1 and 5) and a homologous recombination repair deficiency-like group (signatures 3 and 8), and chromothripsis was investigated using previously established criteria. Progression-free survival and overall survival were modelled for patients with a genetic predisposition to medulloblastoma.FindingsWe included a total of 1022 patients with medulloblastoma from the retrospective cohorts (n=673) and the four prospective studies (n=349), from whom blood samples (n=1022) and tumour samples (n=800) were analysed for germline mutations in 110 cancer predisposition genes. In our rare variant burden analysis, we compared these against 53 105 sequenced controls from ExAC and identified APC, BRCA2, PALB2, PTCH1, SUFU, and TP53 as consensus medulloblastoma predisposition genes according to our rare variant burden analysis and estimated that germline mutations accounted for 6% of medulloblastoma diagnoses in the retrospective cohort. The prevalence of genetic predispositions differed between molecular subgroups in the retrospective cohort and was highest for patients in the MBSHH subgroup (20% in the retrospective cohort). These estimates were replicated in the prospective clinical cohort (germline mutations accounted for 5% of medulloblastoma diagnoses, with the highest prevalence [14%] in the MBSHH subgroup). Patients with germline APC mutations developed MBWNT and accounted for most (five [71%] of seven) cases of MBWNT that had no somatic CTNNB1 exon 3 mutations. Patients with germline mutations in SUFU and PTCH1 mostly developed infant MBSHH. Germline TP53 mutations presented only in childhood patients in the MBSHH subgroup and explained more than half (eight [57%] of 14) of all chromothripsis events in this subgroup. Germline mutations in PALB2 and BRCA2 were observed across the MBSHH, MBGroup3, and MBGroup4 molecular subgroups and were associated with mutational signatures typical of homologous recombination repair deficiency. In patients with a genetic predisposition to medulloblastoma, 5-year progression-free survival was 52% (95% CI 40-69) and 5-year overall survival was 65% (95% CI 52-81); these survival estimates differed significantly across patients with germline mutations in different medulloblastoma predisposition genes.InterpretationGenetic counselling and testing should be used as a standard-of-care procedure in patients with MBWNT and MBSHH because these patients have the highest prevalence of damaging germline mutations in known cancer predisposition genes. We propose criteria for routine genetic screening for patients with medulloblastoma based on clinical and molecular tumour characteristics.FundingGerman Cancer Aid; German Federal Ministry of Education and Research; German Childhood Cancer Foundation (Deutsche Kinderkrebsstiftung); European Research Council; National Institutes of Health; Canadian Institutes for Health Research; German Cancer Research Center; St Jude Comprehensive Cancer Center; American Lebanese Syrian Associated Charities; Swiss National Science Foundation; European Molecular Biology Organization; Cancer Research UK; Hertie Foundation; Alexander and Margaret Stewart Trust; V Foundation for Cancer Research; Sontag Foundation; Musicians Against Childhood Cancer; BC Cancer Foundation; Swedish Council for Health, Working Life and Welfare; Swedish Research Council; Swedish Cancer Society; the Swedish Radiation Protection Authority; Danish Strategic Research Council; Swiss Federal Office of Public Health; Swiss Research Foundation on Mobile Communication; Masaryk University; Ministry of Health of the Czech Republic; Research Council of Norway; Genome Canada; Genome BC; Terry Fox Research Institute; Ontario Institute for Cancer Research; Pediatric Oncology Group of Ontario; The Family of Kathleen Lorette and the Clark H Smith Brain Tumour Centre; Montreal Children's Hospital Foundation; The Hospital for Sick Children: Sonia and Arthur Labatt Brain Tumour Research Centre, Chief of Research Fund, Cancer Genetics Program, Garron Family Cancer Centre, MDT's Garron Family Endowment; BC Childhood Cancer Parents Association; Cure Search Foundation; Pediatric Brain Tumor Foundation; Brainchild; and the Government of Ontario.

Published
2018

12. Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition: A modified Delphi approach to build international consensus-based definitions—International Pediatric Low-Grade Glioma Coalition

Author

O’Hare, Patricia, primary, Cooney, Tabitha, additional, de Blank, Peter, additional, Gutmann, David H, additional, Kieran, Mark, additional, Milde, Till, additional, Fangusaro, Jason, additional, Fisher, Michael, additional, Avula, Shivaram, additional, Packer, Roger, additional, Fukuoka, Kohei, additional, Mankad, Kshitij, additional, Mueller, Sabine, additional, Waanders, Angela J, additional, Opocher, Enrico, additional, Bouffet, Eric, additional, Raabe, Eric, additional, Werle, Natacha Entz, additional, Azizi, Amedeo A, additional, Robison, Nathan J, additional, Hernáiz Driever, Pablo, additional, Russo, Mark, additional, Schouten, Netteke, additional, van Tilburg, Cornelis M, additional, Sehested, Astrid, additional, Grill, Jacques, additional, Bandopadhayay, Pratiti, additional, Kilday, John-Paul, additional, Witt, Olaf, additional, Ashley, David M, additional, Ertl-Wagner, Birgit Betina, additional, Tabori, Uri, additional, and Hargrave, Darren R, additional

Published
2024
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13. Analysis of bihemispheric language function in pediatric neurosurgical patients using repetitive navigated transcranial magnetic stimulation

Author

Rosenstock, Tizian, primary, Schneider, Heike, additional, Neymeyer, Mitra Lara, additional, Becker, Lena-Luise, additional, Schulz, Bettina, additional, Tietze, Anna, additional, Hernáiz Driever, Pablo, additional, Kaindl, Angela M., additional, Vajkoczy, Peter, additional, Picht, Thomas, additional, and Thomale, Ulrich-Wilhelm, additional

Published
2024
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15. Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

Author

Fangusaro, Jason, Witt, Olaf, Hernáiz Driever, Pablo, Bag, Asim K, de Blank, Peter, Kadom, Nadja, Kilburn, Lindsay, Lober, Robert M, Robison, Nathan J, Fisher, Michael J, Packer, Roger J, Young Poussaint, Tina, Papusha, Ludmila, Avula, Shivaram, Brandes, Alba A, Bouffet, Eric, Bowers, Daniel, Artemov, Anton, Chintagumpala, Murali, Zurakowski, David, van den Bent, Martin, Bison, Brigitte, Yeom, Kristen W, Taal, Walter, and Warren, Katherine E

Published
2020
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20. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, primary, Capper, David, additional, Andreiuolo, Felipe, additional, Gessi, Marco, additional, Kölsche, Christian, additional, Reinhardt, Annekathrin, additional, Sievers, Philipp, additional, Wefers, Annika K., additional, Ebrahimi, Azadeh, additional, Suwala, Abigail K., additional, Gielen, Gerrit H., additional, Sill, Martin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Hovestadt, Volker, additional, Daenekas, Bjarne, additional, Rode, Agata, additional, Hamelmann, Stefan, additional, Previti, Christopher, additional, Jäger, Natalie, additional, Buchhalter, Ivo, additional, Blattner-Johnson, Mirjam, additional, Jones, Barbara C., additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Grund, Kerstin, additional, Sutter, Christian, additional, Hirsch, Steffen, additional, Dikow, Nicola, additional, Hasselblatt, Martin, additional, Schüller, Ulrich, additional, Koch, Arend, additional, Gerber, Nicolas U., additional, White, Christine L., additional, Buntine, Molly K., additional, Kinross, Kathryn, additional, Algar, Elizabeth M., additional, Hansford, Jordan R., additional, Gottardo, Nicholas G., additional, Schuhmann, Martin U., additional, Thomale, Ulrich W., additional, Hernáiz Driever, Pablo, additional, Gnekow, Astrid, additional, Witt, Olaf, additional, Müller, Hermann L., additional, Calaminus, Gabriele, additional, Fleischhack, Gudrun, additional, Kordes, Uwe, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Frühwald, Michael C., additional, Kramm, Christof M., additional, von Deimling, Andreas, additional, Pietsch, Torsten, additional, Sahm, Felix, additional, Pfister, Stefan M., additional, and Jones, David. T. W., additional

Published
2023
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22. Neurosurgical morbidity in pediatric supratentorial midline low-grade glioma: Results from the German LGG studies.

Author

Simon, Michèle, primary, Weiß, Sarah, additional, Thomale, Ulrich-Wilhelm, additional, Schulz, Matthias, additional, Kandels, Daniela, additional, Schuhmann, Martin, additional, ElDamaty, Ahmed, additional, Krauss, Juergen, additional, Hernáiz Driever, Pablo, additional, Witt, Olaf, additional, Bison, Brigitte, additional, Pietsch, Torsten, additional, and Astrid, Gnekow, additional

Published
2023
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23. A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma – A final report

Author

Gnekow, Astrid K., Slavc, Irene, Perilongo, Giorgio, Picton, Sue, Walker, David, Stokland, Tore, Sandstrom, Per Erik, Clausen, Niels, Arola, Mikko, Jonsson, Olafur Gisli, Cruz, Ofelia, Navajas, Aurora, Teijeiro, Anna, Grill, Jacques, Kalifa, Chantal, Raquin, Marie-Anne, Verlooy, Joris, Hans, Volkmar, Pietsch, Torsten, Scheurlen, Wolfram, Hainfellner, Johannes, Giangaspero, Felice, Ironside, James, Robson, Keith, Skullerud, Kari, Scheie, David, NN, Ruchoux, Marie-Madeleine, Jouvet, Anne, Figarella-Branger, Dominique, Lellouch-Toubiana, Arielle, Warmuth-Metz, Monika, Prayer, Daniela, Calderone, Milena, Jaspan, Tim, Bakke, Soren Jacob, Vazquez, Eli, Couanet, Dominique, Kortmann, Rolf D., Diekmann, Karin, Scarzello, Giovanni, Taylor, Roger, Lote, Knut, Giralt, Jordi, Carrie, Christian, Habrand, Jean Louis, Soerensen, Niels, Czech, Thomas, Chumas, Paul, Gustavson, Bengt, Zerah, Michel, Wabbels, Bettina, Pinello, Maria Luisa, Fielder, Alistair, Simmons, Ian, Christoffersen, Terje, Calaminus, Gabriele, Brockmann, Knut, Straeter, Ronald, Ebinger, Friedrich, Hernaiz-Driever, Pablo, Lackner, Herwig, Kennedy, Colin, Glaser, Adam, Stromberg, Bo, Indiano, Jose Ma, Rodary, Chantal, Bouffet, Eric, Frappaz, Didier, Faldum, Andreas, Emser, Angela, De Salvo, Gian Luca, Stephens, Suzanne, Machin, David, Le Deley, Marie-Cécile, Egeland, Thore, Freemann, Carolyn, Schrappe, Martin, Sposto, Richard, Walker, David A., Kandels, Daniela, Picton, Susan, Giorgio Perilongo, Sandstrom, Per Eric, Schmidt, René, Kilmartin, Denise, and De Paoli, Angela

Published
2017
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24. Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

Author

Deng, Maximilian Y., Sill, Martin, Chiang, Jason, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Monoranu, Camelia-Maria, Milde, Till, Wittmann, Andrea, Hartmann, Christian, Sommer, Clemens, Paulus, Werner, Gärtner, Jutta, Brück, Wolfgang, Rüdiger, Thomas, Leipold, Alfred, Jaunmuktane, Zane, Brandner, Sebastian, Giangaspero, Felice, Nozza, Paolo, Mora, Jaume, Morales la Madrid, Andres, Cruz Martinez, Ofelia, Hansford, Jordan R., Pietsch, Torsten, Tietze, Anna, Hernáiz-Driever, Pablo, Stoler, Iris, Capper, David, Korshunov, Andrey, Ellison, David W., von Deimling, Andreas, Pfister, Stefan M., Sahm, Felix, and Jones, David T. W.

Published
2018
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25. Development of Laterality and Bimanual Interference of Fine Motor Movements in Childhood and Adolescence.

Author

Nájera Chávez, Brenda Carolina, Rueckriegel, Stefan Mark, Burghardt, Roland, and Hernáiz Driever, Pablo

Subjects
LATERAL dominance, FINE motor ability, ADOLESCENCE, MOTOR ability, CEREBRAL dominance, HANDWRITING, HAND, BODY movement, KINEMATICS
Abstract

Drawing and handwriting are fine motor skills acquired during childhood. We analyzed the development of laterality by comparing the performance of the dominant with the nondominant hand and the effect of bimanual interference in kinematic hand movement parameters (speed, automation, variability, and pressure). Healthy subjects (n = 187, 6-18 years) performed drawing tasks with both hands on a digitizing tablet followed by performance in the presence of an interfering task of the nondominant hand. Age correlated positively with speed, automation, and pressure, and negatively with variability for both hands. As task complexity increased, differences between both hands were less pronounced. Playing an instrument had a positive effect on the nondominant hand. Speed and automation showed a strong association with lateralization. Bimanual interference was associated with an increase of speed and variability. Maturation of hand laterality and the extent of bimanual interference in fine motor tasks are age-dependent processes. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Neurosurgical morbidity in pediatric supratentorial midline low‐grade glioma: results from the German LGG studies

Author

Weiß, Sarah, Thomale, Ulrich‐Wilhelm, Schulz, Matthias, Kandels, Daniela, Schuhmann, Martin U., El Damaty, Ahmed, Krauss, Juergen, Hernáiz Driever, Pablo, Witt, Olaf, Bison, Brigitte, Pietsch, Torsten, Gnekow, Astrid, and Simon, Michèle

Subjects
ddc:610
Abstract

Surgical resection is a mainstay of treatment for pediatric low-grade glioma (LGG) within all current therapy algorithms, yet associated morbidity is scarcely reported. As supratentorial midline (SML) interventions are particularly challenging, we investigated the frequency of neurosurgical complications/new impairments aiming to identify their risk factors. Records were retrospectively analyzed from 318 patients with SML-LGG from successive German multicenter LGG studies, undergoing surgery between May 1998 and June 2020. Exactly 537 operations (230 resections, 167 biopsies, 140 nontumor procedures) were performed in 318 patients (54% male, median age: 7.6 years at diagnosis, 9.5 years at operation, 11% NF1, 42.5% optic pathway glioma). Surgical mortality rate was 0.93%. Applying the Drake classification, postoperative surgical morbidity was observed following 254/537 (47.3%) and medical morbidity following 97/537 (18.1%) patients with a 40.1% 30-day persistence rate for newly developed neurological deficits (65/162). Neuroendocrine impairment affected 53/318 patients (16.7%), visual deterioration 34/318 (10.7%). Postsurgical morbidity was associated with patient age

Published
2023

29. Long-term follow-up of surgical intervention pattern in pediatric low-grade gliomas: report from the German SIOP-LGG 2004 cohort

Author

Thomale, Ulrich-Wilhelm, primary, Gnekow, Astrid K., additional, Kandels, Daniela, additional, Bison, Brigitte, additional, Hernáiz Driever, Pablo, additional, Witt, Olaf, additional, Pietsch, Torsten, additional, Koch, Arend, additional, Capper, David, additional, Kortmann, Rolf-Dieter, additional, Timmermann, Beate, additional, Harrabi, Semi, additional, Simon, Michèle, additional, El Damaty, Ahmed, additional, Krauss, Juergen, additional, Schuhmann, Martin U., additional, and Aigner, Annette, additional

Published
2022
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31. NFB-13. Rhabdoid Tumor Predisposition Syndrome (RTPS) – Finding Evidence by systematic Analyses

Author

Nemes, Karolina, primary, Bens, Susanne, additional, Johann, Pascal D, additional, Steinbügl, Mona, additional, Gruhle, Miriam, additional, Kachanov, Denis, additional, Teleshova, Margarita, additional, Hauser, Peter, additional, Simon, Thorsten, additional, Tippelt, Stephan, additional, Eberl, Wolfgang, additional, Woessmann, Wilhelm, additional, Kratz, Christian, additional, Abbink, Floor, additional, Hernáiz-Driever, Pablo, additional, Eyrich, Matthias, additional, Sumerauer, David, additional, Milde, Till, additional, Reinhard, Harald, additional, Leipold, Alfred, additional, de Wetering, Marianne v, additional, Gil-da-Costa, Maria João, additional, Ebetsberger-Dachs, Georg, additional, Marques, Carmen Hernandez, additional, Bauer, Nina, additional, Biassoni, Veronica, additional, Meneses, Clarice Franco, additional, Knirsch, Stephanie, additional, Lauten, Melchior, additional, Gerber, Nicolas U, additional, Chada, Martin, additional, Kerl, Kornelius, additional, Lemmer, Andreas, additional, Heidrun, Boztug, additional, Kuhlen, Michaela, additional, Furtwängler, Rhoikos, additional, Kordes, Uwe, additional, Schneppenheim, Reiner, additional, Vokuhl, Christian, additional, Hasselblatt, Martin, additional, Kröncke, Thomas, additional, Bison, Brigitte, additional, Melchior, Patrick, additional, Timmermann, Beate, additional, Gerss, Joachim, additional, Siebert, Reiner, additional, and Frühwald, Michael C, additional

Published
2022
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32. ATRT-05. Infants and newborns with atypical teratoid/rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors: a unique and challenging population

Author

Nemes, Karolina, primary, Johann, Pascal D, additional, Steinbügl, Mona, additional, Gruhle, Miriam, additional, Bens, Susanne, additional, Kachanov, Denis, additional, Teleshova, Margarita, additional, Peter, Hauser, additional, Simon, Thorsten, additional, Tippelt, Stephan, additional, Eberl, Wolfgang, additional, Chada, Martin, additional, Lopez, Vicente Santa-Maria, additional, Grigull, Lorenz, additional, Hernáiz-Driever, Pablo, additional, Eyrich, Matthias, additional, Pears, Jane, additional, Milde, Till, additional, Reinhard, Harald, additional, Leipold, Alfred, additional, de Wetering, Marianne v, additional, João Gil-da-Costa, Maria, additional, Ebetsberger-Dachs, Georg, additional, Kerl, Kornelius, additional, Lemmer, Andreas, additional, Boztug, Heidrun, additional, Furtwängler, Rhoikos, additional, Kordes, Uwe, additional, Siebert, Reiner, additional, Vokuhl, Christian, additional, Hasselblatt, Martin, additional, Bison, Brigitte, additional, Kröncke, Thomas, additional, Melchior, Patrick, additional, Timmermann, Beate, additional, Gerss, Joachim, additional, and Frühwald, Michael C, additional

Published
2022
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33. Genomic Evolution and Personalized Therapy of an Infantile Fibrosarcoma Harboring anNTRKOncogenic Fusion

Author

Thorwarth, Anne, primary, Haase, Kerstin, additional, Röefzaad, Claudia, additional, Pajtler, Kristian W., additional, Schramm, Kathrin, additional, Hauptmann, Kathrin, additional, Behnke, Anke, additional, Vokuhl, Christian, additional, Elgeti, Thomas, additional, Gratopp, Alexander, additional, Schulte, Johannes H., additional, Scheer, Monika, additional, Hernáiz Driever, Pablo, additional, Nysom, Karsten, additional, Eggert, Angelika, additional, Henssen, Anton G., additional, and Deubzer, Hedwig E., additional

Published
2022
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34. Infants and Newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB Registry: A Unique and Challenging Population

Author

Nemes, Karolina, primary, Johann, Pascal D., additional, Steinbügl, Mona, additional, Gruhle, Miriam, additional, Bens, Susanne, additional, Kachanov, Denis, additional, Teleshova, Margarita, additional, Hauser, Peter, additional, Simon, Thorsten, additional, Tippelt, Stephan, additional, Eberl, Wolfgang, additional, Chada, Martin, additional, Lopez, Vicente Santa-Maria, additional, Grigull, Lorenz, additional, Hernáiz-Driever, Pablo, additional, Eyrich, Matthias, additional, Pears, Jane, additional, Milde, Till, additional, Reinhard, Harald, additional, Leipold, Alfred, additional, van de Wetering, Marianne, additional, Gil-da-Costa, Maria João, additional, Ebetsberger-Dachs, Georg, additional, Kerl, Kornelius, additional, Lemmer, Andreas, additional, Boztug, Heidrun, additional, Furtwängler, Rhoikos, additional, Kordes, Uwe, additional, Vokuhl, Christian, additional, Hasselblatt, Martin, additional, Bison, Brigitte, additional, Kröncke, Thomas, additional, Melchior, Patrick, additional, Timmermann, Beate, additional, Gerss, Joachim, additional, Siebert, Reiner, additional, and Frühwald, Michael C., additional

Published
2022
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37. Germline Mutations Including the Rare Pathogenic Variant c.3206delC in the ATM Gene Cause Ataxia Teleangiectasia-Associated Primary Central Nervous System Lymphoma

Author

Dörr, Jan R., primary, Thorwarth, Anne, additional, Mizia-Malarz, Agnieszka, additional, Radke, Josefine, additional, Tietze, Anna, additional, Hernáiz-Driever, Pablo, additional, Horn, Denise, additional, Gratopp, Alexander, additional, Eggert, Angelika, additional, and Deubzer, Hedwig E., additional

Published
2021
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42. Age and DNA-methylation subgroup as potential independent risk factors for treatment stratification in children with Atypical Teratoid/Rhabdoid Tumors

Author

Frühwald, Michael C, Hasselblatt, Martin, Nemes, Karolina, Bens, Susanne, Steinbügl, Mona, Johann, Pascal D, Kerl, Kornelius, Hauser, Peter, Quiroga, Eduardo, Solano-Paez, Palma, Biassoni, Veronica, Gil-da-Costa, Maria Joao, Perek-Polnik, Martha, van de Wetering, Marianne, Sumerauer, David, Pears, Jane, Stabell, Niklas, Holm, Stefan, Hengartner, Heinz, Gerber, Nicolas U, Grotzer, Michael, Boos, Joachim, Ebinger, Martin, Tippelt, Stefan, Paulus, Werner, Furtwängler, Rhoikos, Hernáiz-Driever, Pablo, Reinhard, Harald, Rutkowski, Stefan, Schlegel, Paul-Gerhardt, et al, and University of Zurich

Subjects
2728 Neurology (clinical), 10036 Medical Clinic, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2020

43. Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data

Author

Stichel, Damian, primary, Schrimpf, Daniel, additional, Sievers, Philipp, additional, Reinhardt, Annekathrin, additional, Suwala, Abigail K., additional, Sill, Martin, additional, Reuss, David E., additional, Korshunov, Andrey, additional, Casalini, Belén M., additional, Sommerkamp, Alexander C., additional, Ecker, Jonas, additional, Selt, Florian, additional, Sturm, Dominik, additional, Gnekow, Astrid, additional, Koch, Arend, additional, Simon, Michèle, additional, Hernáiz Driever, Pablo, additional, Schüller, Ulrich, additional, Capper, David, additional, Tilburg, Cornelis M., additional, Witt, Olaf, additional, Milde, Till, additional, Pfister, Stefan M., additional, Jones, David T. W., additional, Deimling, Andreas, additional, Sahm, Felix, additional, and Wefers, Annika K., additional

Published
2021
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45. EPEN-18. CROSS-SPECIES GENOMICS IDENTIFIES GLI2 AS AN ONCOGENE OF C11orf95 FUSION-POSITIVE SUPRATENTORIAL EPENDYMOMA

Author

Zheng, Tuyu, primary, Ghasemi, David R, additional, Okonechnikov, Konstantin, additional, Korshunov, Andrey, additional, Sill, Martin, additional, Hübner, Jens-Martin, additional, Maaß, Kendra K, additional, Snuderl, Matija, additional, Gojo, Johannes, additional, Schüller, Ulrich, additional, Gerber, Nicolas U, additional, Hernáiz-Driever, Pablo, additional, Milde, Till, additional, Sturm, Dominik, additional, Chapman, Rebecca, additional, Grundy, Richard G, additional, von Deimling, Andreas, additional, Jones, David T W, additional, Kool, Marcel, additional, Pfister, Stefan M, additional, Sahm, Felix, additional, Kawauchi, Daisuke, additional, and Pajtler, Kristian W, additional

Published
2020
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46. Loss of efficacy of subsequent nonsurgical therapy after primary treatment failure in pediatric low‐grade glioma patients—Report from the German SIOP‐LGG 2004 cohort

Author

Kandels, Daniela, primary, Pietsch, Torsten, additional, Bison, Brigitte, additional, Warmuth‐Metz, Monika, additional, Thomale, Ulrich‐Wilhelm, additional, Kortmann, Rolf‐Dieter, additional, Timmermann, Beate, additional, Hernáiz Driever, Pablo, additional, Witt, Olaf, additional, Schmidt, René, additional, and Gnekow, Astrid K., additional

Published
2020
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47. Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions—report from the German LGG studies

Author

Traunwieser, Thomas, primary, Kandels, Daniela, additional, Pauls, Franz, additional, Pietsch, Torsten, additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Krauss, Juergen, additional, Kortmann, Rolf-Dieter, additional, Timmermann, Beate, additional, Thomale, Ulrich-Wilhelm, additional, Luettich, Peggy, additional, Neumann-Holbeck, Anne, additional, Tischler, Tanja, additional, Hernáiz Driever, Pablo, additional, Witt, Olaf, additional, and Gnekow, Astrid K, additional

Published
2020
Full Text
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48. Age and DNA methylation subgroup as potential independent risk factors for treatment stratification in children with atypical teratoid/rhabdoid tumors

Author

Frühwald, Michael C, primary, Hasselblatt, Martin, primary, Nemes, Karolina, primary, Bens, Susanne, primary, Steinbügl, Mona, primary, Johann, Pascal D, primary, Kerl, Kornelius, primary, Hauser, Peter, primary, Quiroga, Eduardo, primary, Solano-Paez, Palma, primary, Biassoni, Veronica, primary, Gil-da-Costa, Maria Joao, primary, Perek-Polnik, Martha, primary, van de Wetering, Marianne, primary, Sumerauer, David, primary, Pears, Jane, primary, Stabell, Niklas, primary, Holm, Stefan, primary, Hengartner, Heinz, primary, Gerber, Nicolas U, primary, Grotzer, Michael, primary, Boos, Joachim, primary, Ebinger, Martin, primary, Tippelt, Stefan, primary, Paulus, Werner, primary, Furtwängler, Rhoikos, primary, Hernáiz-Driever, Pablo, primary, Reinhard, Harald, primary, Rutkowski, Stefan, primary, Schlegel, Paul-Gerhardt, primary, Schmid, Irene, primary, Kortmann, Rolf-Dieter, primary, Timmermann, Beate, primary, Warmuth-Metz, Monika, primary, Kordes, Uwe, primary, Gerss, Joachim, primary, Nysom, Karsten, primary, Schneppenheim, Reinhard, primary, Siebert, Reiner, primary, Kool, Marcel, primary, and Graf, Norbert, primary

Published
2019
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50. Favorable prognosis in pediatric brainstem low‐grade glioma: Report from the German SIOP‐LGG 2004 cohort

Author

Holzapfel, Johannes, primary, Kandels, Daniela, additional, Schmidt, René, additional, Pietsch, Torsten, additional, Warmuth‐Metz, Monika, additional, Bison, Brigitte, additional, Krauss, Jüergen, additional, Kortmann, Rolf‐Dieter, additional, Timmermann, Beate, additional, Thomale, Ulrich‐Wilhelm, additional, Albert, Michael H., additional, Hernáiz Driever, Pablo, additional, Witt, Olaf, additional, and Gnekow, Astrid K., additional

Published
2019
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