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2. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Aichholzer, Martin, Amorim, Isabel, Aparicio, Javier, Aronica, Eleonora, Arzimanoglou, Alexis, Barba, Carmen, Beck, Jürgen, Becker, Albert, Beckervordersandforth, Jan C, Bien, Christian G, Blümcke, Ingmar, Bodi, Istvan, Braun, Kees PJ, Catenoix, Helene, Chassoux, Francine, Chipaux, Mathilde, Cloppenborg, Thomas, Coras, Roland, Cross, J Helen, De Palma, Luca, De Tisi, Jane, Deleo, Francesco, Devaux, Bertrand, Di Gennaro, Giancarlo, Dorfmüller, Georg, Duncan, John S, Elger, Christian, Ernst, Katharina, Esposito, Vincenzo, Feucht, Martha, Gadze, Zeljka Petelin, Garbelli, Rita, Geleijns, Karin, Gil-Nagel, Antonio, Grote, Alexander, Grunwald, Thomas, Guerrini, Renzo, Hamer, Hajo, Honavar, Mrinalini, Jacques, Thomas S, Jakovcevic, Antonia, Jutila, Leena, Kalina, Adam, Kälviäinen, Reetta, Klein, Karl Martin, Koenig, Kristina, Krsek, Pavel, Kudernatsch, Manfred, Kudr, Martin, Lamberink, Herm J, Malmgren, Kristina, Marusic, Petr, Melikyan, Armen, Menzler, Katja, Noachtar, Soheyl, Otte, Willem M, Özkara, Çiğdem, Pieper, Tom, Pimentel, Jose, Raicevic, Savo, Rheims, Sylvain, Ribeiro, Joana, Rosenow, Felix, Rössler, Karl, Rydenhag, Bertil, Sales, Francisco, San Antonio-Arce, Victoria, Schaller, Karl Lothar, Schijns, Olaf, Scholl, Theresa, Schramm, Johannes, Schulze-Bonhage, Andreas, Sciot, Raf, Seeck, Margitta, Shishkina, Lyudmila, Sokic, Dragoslav, Specchio, Nicola, Theys, Tom, Thom, Maria, Delgado, Rafael Toledano, Toulouse, Joseph, Uzan, Mustafa, van Loon, Johannes, Van Paesschen, Wim, von Oertzen, Tim J, Jansen, Floor, Leijten, Frans, van Rijen, Peter, Spliet, Wim GM, Mühlebner, Angelika, Kasper, Burkhard S, Fauser, Susanne, Polster, Tilman, Kalbhenn, Thilo, Delev, Daniel, McEvoy, Andrew, Miserocchi, Anna, Landré, Elisabeth, Turak, Bares, Varlet, Pascale, Ferrand-Sorbets, Sarah, Fohlen, Martine, Bulteau, Christine, Edelvik, Anna, Shah, Mukesch J, Scheiwe, Christian, Delicado, Eva Gutierrez, Tisdall, Martin, Eltze, Christin, Akkol, Serdar, Deniz, Kaancan, Oz, Buge, Holthausen, Hans, Hartlieb, Till, Staudt, Martin, Casciato, Sara, Quarato, Pier P, Giangaspero, Felice, Streichenberger, Nathalie, Guenot, Marc, Isnard, Jean, Valentijn, Antonio, Chang, Amanda, Mullatti, Nandini, Zamecnik, Josef, Zarubova, Jana, Tomasek, Martin, Immonen, Arto, Saarela, Anni, Rauramaa, Tuomas, Lobrinus, Johannes A, Egervari, Kristof, Momjian, Shahan, Harti, Elisabeth, Lohr, Hannah, Kroell, Judith, Vermeulen, Lynn, Cleeren, Evy, Vlasov, Pavel, Kozlova, Antonia, Vorobyev, Alexey, Goeppel, Gudrun, Samueli, Sharon, Czech, Thomas, Hainfellner, Johannes, Puttinger, Gertraud, Schwarz, Gabriele, Stefanits, Harald, Weis, Serge, Spreafico, Roberto, Villani, Flavio, Rossini, Laura, Hermsen, Anke, Knake, Susanne, Nimsky, Christopher, Carl, Barbara, Belohlavkova, Anezka, Benova, Barbora, Bisschop, Jeroen, Colon, Albert, van Kranen-Mastenbroek, Vivianne, Rouhl, Rob PW, Hoogland, Govert, Rumiá, Jordi, Ramírez-Camacho, Alia, Candela-Cantó, Santiago, Ostrowsky-Coste, Karine, Panagiotakaki, Eleni, Montavont, Alexandra, Kosal, Pascale Keo, Gokce-Samar, Zeynep, Milleret, Clara, Buccoliero, Anna M, Giordano, Flavio, Sulentic, Vlatko, Mrak, Goran, Desnica, Andrej, CarfíPavia, Giusy, De Benedictis, Alessandro, Marras, Carlo E, Bascarevic, Vladimir, Vojvodic, Nikola, Ristic, Aleksandar, Rebelo, Olinda, Aledo-Serrano, Angel, Garcia-Morales, Irene, Anciones, Carla, and Braun, Kees P J

Published
2020
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5. Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Author

Conradi, Nadine, Rosenberg, Friederike, Knake, Susanne, Biermann, Louise, Haag, Anja, Gorny, Iris, Hermsen, Anke, von Podewils, Viola, Behrens, Marion, Gurschi, Marianna, du Mesnil de Rochemont, Richard, Menzler, Katja, Bauer, Sebastian, Schubert-Bast, Susanne, Nimsky, Christopher, Konczalla, Jürgen, Rosenow, Felix, and Strzelczyk, Adam

Published
2021
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8. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

Author

Blumcke, Ingmar, Spreafico, Roberto, Haaker, Gerrit, Coras, Roland, Kobow, Katja, Bien, Christian G., Pfäfflin, Margarete, Elger, Christian, Widman, Guido, Schramm, Johannes, Becker, Albert, Braun, Kees P., Leijten, Frans, Baayen, Johannes C., Aronica, Eleonora, Chassoux, Francine, Hamer, Hajo, Stefan, Hermann, Rössler, Karl, Thom, Maria, Walker, Matthew C., Sisodiya, Sanjay M., Duncan, John S., McEvoy, Andrew W., Pieper, Tom, Holthausen, Hans, Kudernatsch, Manfred, Meencke, Joachim H., Kahane, Philippe, Schulze-Bonhage, Andreas, Zentner, Josef, Heiland, Dieter H., Urbach, Horst, Steinhoff, Bernhard J., Bast, Thomas, Tassi, Laura, Lo Russo, Giorgio, Özkara, Cigdem, Oz, Buge, Krsek, Pavel, Vogelgesang, Silke, Runge, Uwe, Lerche, Holger, Weber, Yvonne, Honavar, Mrinalini, Pimentel, José, Arzimanoglou, Alexis, Ulate-Campos, Adriana, Noachtar, Soheyl, Hartl, Elisabeth, Schijns, Olaf, Guerrini, Renzo, Barba, Carmen, Jacques, Thomas S., Cross, Helen J., Feucht, Martha, Mühlebner, Angelika, Grunwald, Thomas, Trinka, Eugen, Winkler, Peter A., Gil-Nagel, Antonio, Delgado, Rafael Toledano, Mayer, Thomas, Lutz, Martin, Zountsas, Basilios, Garganis, Kyriakos, Rosenow, Felix, Hermsen, Anke, von Oertzen, Tim J., Diepgen, Thomas L., and Avanzini, Giuliano

Published
2017
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10. Predictors of and attitudes toward counseling about SUDEP and other epilepsy risk factors among Austrian, German, and Swiss neurologists and neuropediatricians

Author

Strzelczyk, Adam, Zschebek, Gerda, Bauer, Sebastian, Baumgartner, Christoph, Grond, Martin, Hermsen, Anke, Kieslich, Matthias, Krämer, Günter, Kurlemann, Gerhard, May, Theodor W., Mayer, Thomas, Neubauer, Bernd A., Pfäfflin, Margarete, Plecko, Barbara, Ryvlin, Philippe, Schubert-Bast, Susanne, Stefan, Hermann, Trinka, Eugen, Knake, Susanne, Seifart, Carola, and Rosenow, Felix

Published
2016
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12. Assessing cognitive change and quality of life 12 months after epilepsy surgery - development and application of reliable change indices and standardized regression-based change norms for a neuropsychological test battery in the german language

Author

Conradi, Nadine, Behrens, Marion, Hermsen, Anke Maria, Kannemann, Tabitha, Merkel, Nina, Schuster, Annika, Freiman, Thomas Michael, Strzelczyk, Adam, and Rosenow, Felix

Subjects
ddc:610
Abstract

Objective: The establishment of patient-centered measures capable of empirically determining meaningful cognitive change after surgery can significantly improve the medical care of epilepsy patients. Thus, this study aimed to develop reliable change indices (RCIs) and standardized regression-based (SRB) change norms for a comprehensive neuropsychological test battery in the German language. Methods: Forty-seven consecutive patients with temporal lobe epilepsy underwent neuropsychological assessments, both before and 12 months after surgery. Practice-effect-adjusted RCIs and SRB change norms for each test score were computed. To assess their usefulness, the presented methods were applied to a clinical sample, and binary logistic regression analyses were conducted to model the odds of achieving improvement in quality of life (QOL) after surgery. Results: The determined RCIs at 90% confidence intervals and the SRB equations for each test score included in the test battery are provided. Cohen’s kappa analyses revealed a moderate mean agreement between the two measures, varying from slight to almost perfect agreement across test scores. Using these measures, a negative association between improvement in QOL and decline in verbal memory functions after surgery was detected (adjusted odds ratio = 0.09, p = 0.006). Significance: To the best of our knowledge, this study is the first to develop RCIs and SRB change norms necessary for the objective determination of neuropsychological change in a comprehensive test battery in the German language, facilitating the individual monitoring of improvement and decline in each patients’ cognitive functioning and psychosocial situations after epilepsy surgery. The application of the described measures revealed a strong negative association between improvement in QOL and decline in verbal memory functions after surgery.

Published
2020

14. Assessing Cognitive Change and Quality of Life 12 Months After Epilepsy Surgery—Development and Application of Reliable Change Indices and Standardized Regression-Based Change Norms for a Neuropsychological Test Battery in the German Language

Author

Conradi, Nadine, primary, Behrens, Marion, additional, Hermsen, Anke M., additional, Kannemann, Tabitha, additional, Merkel, Nina, additional, Schuster, Annika, additional, Freiman, Thomas M., additional, Strzelczyk, Adam, additional, and Rosenow, Felix, additional

Published
2020
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17. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Lamberink, Herm J, primary, Otte, Willem M, additional, Blümcke, Ingmar, additional, Braun, Kees P J, additional, Aichholzer, Martin, additional, Amorim, Isabel, additional, Aparicio, Javier, additional, Aronica, Eleonora, additional, Arzimanoglou, Alexis, additional, Barba, Carmen, additional, Beck, Jürgen, additional, Becker, Albert, additional, Beckervordersandforth, Jan C, additional, Bien, Christian G, additional, Bodi, Istvan, additional, Braun, Kees PJ, additional, Catenoix, Helene, additional, Chassoux, Francine, additional, Chipaux, Mathilde, additional, Cloppenborg, Thomas, additional, Coras, Roland, additional, Cross, J Helen, additional, De Palma, Luca, additional, De Tisi, Jane, additional, Deleo, Francesco, additional, Devaux, Bertrand, additional, Di Gennaro, Giancarlo, additional, Dorfmüller, Georg, additional, Duncan, John S, additional, Elger, Christian, additional, Ernst, Katharina, additional, Esposito, Vincenzo, additional, Feucht, Martha, additional, Gadze, Zeljka Petelin, additional, Garbelli, Rita, additional, Geleijns, Karin, additional, Gil-Nagel, Antonio, additional, Grote, Alexander, additional, Grunwald, Thomas, additional, Guerrini, Renzo, additional, Hamer, Hajo, additional, Honavar, Mrinalini, additional, Jacques, Thomas S, additional, Jakovcevic, Antonia, additional, Jutila, Leena, additional, Kalina, Adam, additional, Kälviäinen, Reetta, additional, Klein, Karl Martin, additional, Koenig, Kristina, additional, Krsek, Pavel, additional, Kudernatsch, Manfred, additional, Kudr, Martin, additional, Lamberink, Herm J, additional, Malmgren, Kristina, additional, Marusic, Petr, additional, Melikyan, Armen, additional, Menzler, Katja, additional, Noachtar, Soheyl, additional, Özkara, Çiğdem, additional, Pieper, Tom, additional, Pimentel, Jose, additional, Raicevic, Savo, additional, Rheims, Sylvain, additional, Ribeiro, Joana, additional, Rosenow, Felix, additional, Rössler, Karl, additional, Rydenhag, Bertil, additional, Sales, Francisco, additional, San Antonio-Arce, Victoria, additional, Schaller, Karl Lothar, additional, Schijns, Olaf, additional, Scholl, Theresa, additional, Schramm, Johannes, additional, Schulze-Bonhage, Andreas, additional, Sciot, Raf, additional, Seeck, Margitta, additional, Shishkina, Lyudmila, additional, Sokic, Dragoslav, additional, Specchio, Nicola, additional, Theys, Tom, additional, Thom, Maria, additional, Delgado, Rafael Toledano, additional, Toulouse, Joseph, additional, Uzan, Mustafa, additional, van Loon, Johannes, additional, Van Paesschen, Wim, additional, von Oertzen, Tim J, additional, Jansen, Floor, additional, Leijten, Frans, additional, van Rijen, Peter, additional, Spliet, Wim GM, additional, Mühlebner, Angelika, additional, Kasper, Burkhard S, additional, Fauser, Susanne, additional, Polster, Tilman, additional, Kalbhenn, Thilo, additional, Delev, Daniel, additional, McEvoy, Andrew, additional, Miserocchi, Anna, additional, Landré, Elisabeth, additional, Turak, Bares, additional, Varlet, Pascale, additional, Ferrand-Sorbets, Sarah, additional, Fohlen, Martine, additional, Bulteau, Christine, additional, Edelvik, Anna, additional, Shah, Mukesch J, additional, Scheiwe, Christian, additional, Delicado, Eva Gutierrez, additional, Tisdall, Martin, additional, Eltze, Christin, additional, Akkol, Serdar, additional, Deniz, Kaancan, additional, Oz, Buge, additional, Holthausen, Hans, additional, Hartlieb, Till, additional, Staudt, Martin, additional, Casciato, Sara, additional, Quarato, Pier P, additional, Giangaspero, Felice, additional, Streichenberger, Nathalie, additional, Guenot, Marc, additional, Isnard, Jean, additional, Valentijn, Antonio, additional, Chang, Amanda, additional, Mullatti, Nandini, additional, Zamecnik, Josef, additional, Zarubova, Jana, additional, Tomasek, Martin, additional, Immonen, Arto, additional, Saarela, Anni, additional, Rauramaa, Tuomas, additional, Lobrinus, Johannes A, additional, Egervari, Kristof, additional, Momjian, Shahan, additional, Harti, Elisabeth, additional, Lohr, Hannah, additional, Kroell, Judith, additional, Vermeulen, Lynn, additional, Cleeren, Evy, additional, Vlasov, Pavel, additional, Kozlova, Antonia, additional, Vorobyev, Alexey, additional, Goeppel, Gudrun, additional, Samueli, Sharon, additional, Czech, Thomas, additional, Hainfellner, Johannes, additional, Puttinger, Gertraud, additional, Schwarz, Gabriele, additional, Stefanits, Harald, additional, Weis, Serge, additional, Spreafico, Roberto, additional, Villani, Flavio, additional, Rossini, Laura, additional, Hermsen, Anke, additional, Knake, Susanne, additional, Nimsky, Christopher, additional, Carl, Barbara, additional, Belohlavkova, Anezka, additional, Benova, Barbora, additional, Bisschop, Jeroen, additional, Colon, Albert, additional, van Kranen-Mastenbroek, Vivianne, additional, Rouhl, Rob PW, additional, Hoogland, Govert, additional, Rumiá, Jordi, additional, Ramírez-Camacho, Alia, additional, Candela-Cantó, Santiago, additional, Ostrowsky-Coste, Karine, additional, Panagiotakaki, Eleni, additional, Montavont, Alexandra, additional, Kosal, Pascale Keo, additional, Gokce-Samar, Zeynep, additional, Milleret, Clara, additional, Buccoliero, Anna M, additional, Giordano, Flavio, additional, Sulentic, Vlatko, additional, Mrak, Goran, additional, Desnica, Andrej, additional, CarfíPavia, Giusy, additional, De Benedictis, Alessandro, additional, Marras, Carlo E, additional, Bascarevic, Vladimir, additional, Vojvodic, Nikola, additional, Ristic, Aleksandar, additional, Rebelo, Olinda, additional, Aledo-Serrano, Angel, additional, Garcia-Morales, Irene, additional, and Anciones, Carla, additional

Published
2020
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19. Incidence, risk factors and consequences of epilepsy-related injuries and accidents : a retrospective, single center study

Author

Willems, Laurent Maximilian, Watermann, Nina, Richter, Saskia, Kay, Lara, Hermsen, Anke Maria, Knake, Susanne, Rosenow, Felix, Strzelczyk, Adam, and Cendes, Fernando

Subjects
ddc:610
Abstract

Introduction: This study was designed to evaluate risk factors and incidence of epilepsy-related injuries and accidents (ERIA) at an outpatient clinic of a German epilepsy center providing healthcare to a mixed urban and rural population of over one million inhabitants. Methods: Data acquisition was performed between 10/2013 and 09/2014 using a validated patient questionnaire on socioeconomic status, course of epilepsy, quality of life (QoL), depression, injuries and accidents associated with seizures or inadequate periictal patterns of behavior concerning a period of 3 months. Univariate analysis, multiple testing and regression analysis were performed to identify possible variables associated with ERIA. Results: A total of 292 patients (mean age 40.8 years, range 18–86; 55% female) were enrolled and analyzed. Focal epilepsy was diagnosed in 75% of the patients. The majority was on an antiepileptic drug (AEDs) polytherapy (mean number of AEDs: 1.65). Overall, 41 patients (14.0%) suffered from epilepsy-related injuries and accidents in a 3-month period. Besides lacerations (n = 18, 6.2%), abrasions and bruises (n = 9, 3.1%), fractures (n = 6, 2.2%) and burns (n = 3, 1.0%), 17 mild injuries (5.8%) were reported. In 20 (6.8% of the total cohort) cases, urgent medical treatment with hospitalization was necessary. Epilepsy-related injuries and accidents were related to active epilepsy, occurrence of generalized tonic-clonic seizures (GTCS) and drug-refractory course as well as reported ictal falls, ictal loss of consciousness and abnormal peri-ictal behavior in the medical history. In addition, patients with ERIA had significantly higher depression rates and lower QoL. Conclusion: ERIA and their consequences should be given more attention and standardized assessment for ERIA should be performed in every outpatient visit.

Published
2018

20. Incidence, Risk Factors and Consequences of Epilepsy-Related Injuries and Accidents: A Retrospective, Single Center Study

Author

Willems, Laurent M., Watermann, Nina, Richter, Saskia, Kay, Lara, Hermsen, Anke M., Knake, Susanne, Rosenow, Felix, and Strzelczyk, Adam

Subjects
Neurology, seizure, falls, laceration, epilepsy, accident, Neurology (clinical), Original Research
Abstract

Introduction: This study was designed to evaluate risk factors and incidence of epilepsy-related injuries and accidents (ERIA) at an outpatient clinic of a German epilepsy center providing healthcare to a mixed urban and rural population of over one million inhabitants. Methods: Data acquisition was performed between 10/2013 and 09/2014 using a validated patient questionnaire on socioeconomic status, course of epilepsy, quality of life (QoL), depression, injuries and accidents associated with seizures or inadequate periictal patterns of behavior concerning a period of 3 months. Univariate analysis, multiple testing and regression analysis were performed to identify possible variables associated with ERIA. Results: A total of 292 patients (mean age 40.8 years, range 18–86; 55% female) were enrolled and analyzed. Focal epilepsy was diagnosed in 75% of the patients. The majority was on an antiepileptic drug (AEDs) polytherapy (mean number of AEDs: 1.65). Overall, 41 patients (14.0%) suffered from epilepsy-related injuries and accidents in a 3-month period. Besides lacerations (n = 18, 6.2%), abrasions and bruises (n = 9, 3.1%), fractures (n = 6, 2.2%) and burns (n = 3, 1.0%), 17 mild injuries (5.8%) were reported. In 20 (6.8% of the total cohort) cases, urgent medical treatment with hospitalization was necessary. Epilepsy-related injuries and accidents were related to active epilepsy, occurrence of generalized tonic-clonic seizures (GTCS) and drug-refractory course as well as reported ictal falls, ictal loss of consciousness and abnormal peri-ictal behavior in the medical history. In addition, patients with ERIA had significantly higher depression rates and lower QoL. Conclusion: ERIA and their consequences should be given more attention and standardized assessment for ERIA should be performed in every outpatient visit.

Published
2018
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22. Limitations of a Short Demographic Questionnaire for Bedside Estimation of Patients’ Global Cognitive Functioning in Epilepsy Patients

Author

Gorny, Iris, primary, Krause, Kristina, additional, Albert, Anita, additional, Schneider, Sabrina, additional, Möller, Leona, additional, Habermehl, Lena, additional, Strzelczyk, Adam, additional, Rosenow, Felix, additional, Hermsen, Anke, additional, Knake, Susanne, additional, and Menzler, Katja, additional

Published
2018
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23. Personalized translational epilepsy research — Novel approaches and future perspectives

Author

Bauer, Sebastian, primary, van Alphen, Natascha, additional, Becker, Albert, additional, Chiocchetti, Andreas, additional, Deichmann, Ralf, additional, Deller, Thomas, additional, Freiman, Thomas, additional, Freitag, Christine M., additional, Gehrig, Johannes, additional, Hermsen, Anke M., additional, Jedlicka, Peter, additional, Kell, Christian, additional, Klein, Karl Martin, additional, Knake, Susanne, additional, Kullmann, Dimitri M., additional, Liebner, Stefan, additional, Norwood, Braxton A., additional, Omigie, Diana, additional, Plate, Karlheinz, additional, Reif, Andreas, additional, Reif, Philipp S., additional, Reiss, Yvonne, additional, Roeper, Jochen, additional, Ronellenfitsch, Michael W., additional, Schorge, Stephanie, additional, Schratt, Gerhard, additional, Schwarzacher, Stephan W., additional, Steinbach, Joachim P., additional, Strzelczyk, Adam, additional, Triesch, Jochen, additional, Wagner, Marlies, additional, Walker, Matthew C., additional, von Wegner, Frederic, additional, and Rosenow, Felix, additional

Published
2017
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24. Personalized translational epilepsy research — Novel approaches and future perspectives

Author

Rosenow, Felix, primary, van Alphen, Natascha, additional, Becker, Albert, additional, Chiocchetti, Andreas, additional, Deichmann, Ralf, additional, Deller, Thomas, additional, Freiman, Thomas, additional, Freitag, Christine M., additional, Gehrig, Johannes, additional, Hermsen, Anke M., additional, Jedlicka, Peter, additional, Kell, Christian, additional, Klein, Karl Martin, additional, Knake, Susanne, additional, Kullmann, Dimitri M., additional, Liebner, Stefan, additional, Norwood, Braxton A., additional, Omigie, Diana, additional, Plate, Karlheinz, additional, Reif, Andreas, additional, Reif, Philipp S., additional, Reiss, Yvonne, additional, Roeper, Jochen, additional, Ronellenfitsch, Michael W., additional, Schorge, Stephanie, additional, Schratt, Gerhard, additional, Schwarzacher, Stephan W., additional, Steinbach, Joachim P., additional, Strzelczyk, Adam, additional, Triesch, Jochen, additional, Wagner, Marlies, additional, Walker, Matthew C., additional, von Wegner, Frederic, additional, and Bauer, Sebastian, additional

Published
2017
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25. Microstructural white matter changes and their relation to neuropsychological deficits in patients with juvenile myoclonic epilepsy

Author

Knake, Susanne, primary, Roth, Christine, additional, Belke, Marcus, additional, Sonntag, Jens, additional, Kniess, Tobias, additional, Krach, Soeren, additional, Jansen, Andreas, additional, Sommer, Jens, additional, Paulus, Frieder M., additional, Carl, Barbara, additional, Rosenow, Felix, additional, Hermsen, Anke M., additional, and Menzler, Katja, additional

Published
2017
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26. Ictal conduction aphasia and ictal angular gyrus syndrome as rare manifestations of epilepsy: The importance of ictal testing during video-EEG monitoring

Author

Zöllner, Johann Philipp, primary, Haag, Anja, additional, Hermsen, Anke, additional, Bauer, Sebastian, additional, Stahl, Friederike, additional, Wulf, Karina, additional, Menzler, Katja, additional, Reif, Philipp S., additional, Wagner, Marlies, additional, Pagenstecher, Axel, additional, Sure, Ulrich, additional, Knake, Susanne, additional, Rosenow, Felix, additional, and Strzelczyk, Adam, additional

Published
2017
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27. Transkranielle Magnetstimulation (TMS)- Einflussfaktoren auf die kortikale Erregbarkeit und Retest-Reliabilität der TMS

Author

Hermsen, Anke Maria and Schwarting, Rainer (Prof. Dr.)

Subjects
ddc:150, non-invasive Stimulation, Epilepsie, epilepsy, Reliabilität, electrophysiology, Wiederholbarkeit, Elektrophysiologie, Repeatability, non-invasive stimulation, Psychology, non-invasive Stimulation -- Epilepsie -- epilepsy -- Reliabilität -- Psychologie -- electrophysiology -- Wiederholbarkeit -- Elektrophysiologie -- Repeatability -- non-invasive stimulation
Abstract

Die transkranielle Magnetstimulation (TMS) ist ein Verfahren zur Messung der kortikalen Erregbarkeit beim Menschen. Letztere ist durch verschiedene Einflüsse veränderbar und wird in pharmakologischen Studien zur Bestimmung eines Effektprofils, aber auch zu Therapie-zwecken, eingesetzt. Verschiedene neurologische Erkrankungen gehen dabei mit einer veränderten kortikalen Erregbarkeit einher. Bei Epilepsien sind je nach Syndrom verschiedene Parameter sowohl der Inhibition als auch der Exzitation verändert. Der Einfluss von Antikonvulsiva als zentralnervös wirksame Substanzen zum Erreichen einer Anfalls-freiheit wurde untersucht. Die vorliegenden Arbeiten befassten sich einerseits mit stoffwechsel¬bedingten und genetischen Einflussfaktoren auf die mittels TMS gemessene kortikale Erregbarkeit sowie der Retest- Reliabilität, d.h. der Güte der Wiederholbarkeit der TMS. Die prospektive Untersuchung von Patienten mit einer Hyperkalzämie im Rahmen einer endokrinologischen Erkrankung (primärer Hyperparathyroidismus) konnte keine Veränderung der Exzitabilität durch einen geänderten Kalziumspiegel nach erfolgreicher Operation nachweisen. In einer weiteren Studie konnte bei gesunden Probanden mit einem Genpolymorphismus des SCN1A-Gens, ein differenzieller Einfluss desselbigen auf einen inhibitorischen Parameter, nach Einnahme des Natrium¬kanalblockers Carbamazepin, nachgewiesen werden. Die TMS kann hier einen Beitrag zur Klärung pharma¬kogenetischer Einflüsse leisten. Die Messgüte der TMS, im Sinne einer guten Wiederholbarkeit, ist für die meisten Einzel- und Doppelpuls-Parameter, bei einem gut definierten Kollektiv von gesunden Probanden unter Einbeziehung von weiblichen Studienteilnehmern in einer anderen eingegangenen Studie, objektiviert worden. Die TMS ist als non-invasives Verfahren zur Messung der kortikalen Erregbarkeit ein für viele Bereiche einsetzbares, robustes Instrument, welches vor allem in Kombination mit weiteren Messtechniken als wertvolles Instrument für die neurophysiologische Forschung eingesetzt werden kann.

Published
2015

28. Influence of the Nonergot Dopamine Agonist Piribedil on Vigilance in Patients With Parkinson Disease and Excessive Daytime Sleepiness (PiViCog-PD)

Author

Eggert, Karla, primary, Öhlwein, Christian, additional, Kassubek, Jan, additional, Wolz, Martin, additional, Kupsch, Andreas, additional, Ceballos-Baumann, Andres, additional, Ehret, Reinhard, additional, Polzer, Udo, additional, Klostermann, Fabian, additional, Schwarz, Johannes, additional, Fuchs, Gerd, additional, Jost, Wolfgang, additional, Albert, Anita, additional, Haag, Anja, additional, Hermsen, Anke, additional, Lohmüller, Karin, additional, Kuhn, Katrin, additional, Wangemann, Martina, additional, and Oertel, Wolfgang H., additional

Published
2014
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32. A common SCN1 A splice-site polymorphism modifies the effect of carbamazepine on cortical excitability-A pharmacogenetic transcranial magnetic stimulation study.

Author

Menzler, Katja, Hermsen, Anke, Balkenhol, Katharina, Duddek, Caroline, Bugiel, Hannes, Bauer, Sebastian, Schorge, Stephanie, Reif, Philipp S., Klein, Karl Martin, Haag, Anja, Oertel, Wolfgang H., Hamer, Hajo M., Knake, Susanne, Trucks, Holger, Sander, Thomas, and Rosenow, Felix

Subjects
*GENETIC polymorphisms, *CARBAMAZEPINE, *PHARMACOGENOMICS, *TRANSCRANIAL magnetic stimulation, *SODIUM channels, *PATHOLOGICAL physiology, *ELECTROPHYSIOLOGY
Abstract

Objective SCN1 A encodes the alpha subunit of the voltage-gated sodium channel and plays a crucial role in several epilepsy syndromes. The common SCN1 A splice-site polymorphism rs3812718 ( IVS5 N+5 G> A) might contribute to the pathophysiology underlying genetic generalized epilepsies and is associated with electrophysiologic properties of the channel and the effect of sodium-channel blocking antiepileptic drugs. We assessed the effects of the rs3812718 genotype on cortical excitability at baseline and after administration of carbamazepine in order to investigate the mechanism of this association. Methods Paired-pulse transcranial magnetic stimulation ( TMS) was applied in 92 healthy volunteers with the homozygous genotypes AA or GG of rs3812718 at baseline and after application of 400 mg of carbamazepine or placebo in a double-blind, randomized, crossover design. Resting motor threshold ( RMT), short interval intracortical inhibition ( SICI), intracortical facilitation ( ICF), and cortical silent period ( CSP) were determined. Results At baseline there was no significant difference in any TMS parameter. Genotype GG was associated with a higher carbamazepine-induced increase in CSP duration as compared to AA (multivariate analysis of covariance [ MANCOVA], p = 0.013). An expected significant increase in RMT was genotype independent. Significance We found that the rs3812718 genotype modifies the effect of carbamazepine on CSP duration (mainly reflecting modulation of γ-aminobutyric acid ( GABA)ergic inhibition), but not on RMT (mainly reflecting modulation of voltage-gated sodium channels). This provides evidence that rs3812718 affects the pharmacoresponse to carbamazepine via an effect on GABAergic cortical interneurons. Our results also confirm that TMS is useful to investigate the effect of genetic variants on cortical excitability and pharmacoresponse. [ABSTRACT FROM AUTHOR]

Published
2014
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