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1. Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET

Author

Kaiser, Lena, Quach, S., Zounek, A. J., Wiestler, B., Zatcepin, A., Holzgreve, A., Bollenbacher, A., Bartos, L. M., Ruf, V. C., Böning, G., Thon, N., Herms, J., Riemenschneider, M. J., Stöcklein, S., Brendel, M., Rupprecht, R., Tonn, J. C., Bartenstein, P., von Baumgarten, L., Ziegler, S., and Albert, N. L.

Published
2024
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3. Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET.

Author

Kaiser, Lena, Quach, S., Zounek, A. J., Wiestler, B., Zatcepin, A., Holzgreve, A., Bollenbacher, A., Bartos, L. M., Ruf, V. C., Böning, G., Thon, N., Herms, J., Riemenschneider, M. J., Stöcklein, S., Brendel, M., Rupprecht, R., Tonn, J. C., Bartenstein, P., von Baumgarten, L., and Ziegler, S.

Subjects
POSITRON emission tomography, RADIOMICS, CENTRAL nervous system tumors, RECEIVER operating characteristic curves, MAGNETIC resonance imaging, FEATURE extraction
Abstract

Purpose: According to the World Health Organization classification for tumors of the central nervous system, mutation status of the isocitrate dehydrogenase (IDH) genes has become a major diagnostic discriminator for gliomas. Therefore, imaging-based prediction of IDH mutation status is of high interest for individual patient management. We compared and evaluated the diagnostic value of radiomics derived from dual positron emission tomography (PET) and magnetic resonance imaging (MRI) data to predict the IDH mutation status non-invasively. Methods: Eighty-seven glioma patients at initial diagnosis who underwent PET targeting the translocator protein (TSPO) using [18F]GE-180, dynamic amino acid PET using [18F]FET, and T1-/T2-weighted MRI scans were examined. In addition to calculating tumor-to-background ratio (TBR) images for all modalities, parametric images quantifying dynamic [18F]FET PET information were generated. Radiomic features were extracted from TBR and parametric images. The area under the receiver operating characteristic curve (AUC) was employed to assess the performance of logistic regression (LR) classifiers. To report robust estimates, nested cross-validation with five folds and 50 repeats was applied. Results: TBRGE-180 features extracted from TSPO-positive volumes had the highest predictive power among TBR images (AUC 0.88, with age as co-factor 0.94). Dynamic [18F]FET PET reached a similarly high performance (0.94, with age 0.96). The highest LR coefficients in multimodal analyses included TBRGE-180 features, parameters from kinetic and early static [18F]FET PET images, age, and the features from TBRT2 images such as the kurtosis (0.97). Conclusion: The findings suggest that incorporating TBRGE-180 features along with kinetic information from dynamic [18F]FET PET, kurtosis from TBRT2, and age can yield very high predictability of IDH mutation status, thus potentially improving early patient management. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Multimodale Radiomicsanalysen zur Prädiktion des IDH-Mutationsstatus bei erstdiagnostizierten Gliomen

Author

Kaiser, L., additional, Quach, S., additional, Zounek, A. J., additional, Zatcepin, A., additional, Holzgreve, A., additional, Bollenbacher, A., additional, Bartos, L., additional, Ruf, V., additional, Böning, G., additional, von Baumgarten, L., additional, Thon, N., additional, Herms, J., additional, Riemenschneider, M. J., additional, Stöcklein, S., additional, Brendel, M., additional, Rupprecht, R., additional, Tonn, J. C., additional, Bartenstein, P., additional, Ziegler, S., additional, and Albert, N. L., additional

Published
2023
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14. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.

Author

Hopfner, F, Tietz, AK, Ruf, VC, Ross, OA, Koga, S, Dickson, D, Aguzzi, A, Attems, J, Beach, T, Beller, A, Cheshire, WP, van Deerlin, V, Desplats, P, Deuschl, G, Duyckaerts, C, Ellinghaus, D, Evsyukov, V, Flanagan, ME, Franke, A, Frosch, MP, Gearing, M, Gelpi, E, van Gerpen, JA, Ghetti, B, Glass, JD, Grinberg, LT, Halliday, G, Helbig, I, Höllerhage, M, Huitinga, I, Irwin, DJ, Keene, DC, Kovacs, GG, Lee, EB, Levin, J, Martí, MJ, Mackenzie, I, McKeith, I, Mclean, C, Mollenhauer, B, Neumann, M, Newell, KL, Pantelyat, A, Pendziwiat, M, Peters, A, Molina Porcel, L, Rabano, A, Matěj, R, Rajput, A, Reimann, R, Scott, WK, Seeley, W, Selvackadunco, S, Simuni, T, Stadelmann, C, Svenningsson, P, Thomas, A, Trenkwalder, C, Troakes, C, Trojanowski, JQ, Uitti, RJ, White, CL, Wszolek, ZK, Xie, T, Ximelis, T, Yebenes, J, Alzheimer's Disease Genetics Consortium, Müller, U, Schellenberg, GD, Herms, J, Kuhlenbäumer, G, Höglinger, G, Hopfner, F, Tietz, AK, Ruf, VC, Ross, OA, Koga, S, Dickson, D, Aguzzi, A, Attems, J, Beach, T, Beller, A, Cheshire, WP, van Deerlin, V, Desplats, P, Deuschl, G, Duyckaerts, C, Ellinghaus, D, Evsyukov, V, Flanagan, ME, Franke, A, Frosch, MP, Gearing, M, Gelpi, E, van Gerpen, JA, Ghetti, B, Glass, JD, Grinberg, LT, Halliday, G, Helbig, I, Höllerhage, M, Huitinga, I, Irwin, DJ, Keene, DC, Kovacs, GG, Lee, EB, Levin, J, Martí, MJ, Mackenzie, I, McKeith, I, Mclean, C, Mollenhauer, B, Neumann, M, Newell, KL, Pantelyat, A, Pendziwiat, M, Peters, A, Molina Porcel, L, Rabano, A, Matěj, R, Rajput, A, Reimann, R, Scott, WK, Seeley, W, Selvackadunco, S, Simuni, T, Stadelmann, C, Svenningsson, P, Thomas, A, Trenkwalder, C, Troakes, C, Trojanowski, JQ, Uitti, RJ, White, CL, Wszolek, ZK, Xie, T, Ximelis, T, Yebenes, J, Alzheimer's Disease Genetics Consortium, Müller, U, Schellenberg, GD, Herms, J, Kuhlenbäumer, G, and Höglinger, G

Published
2022

15. Tau deposition patterns are associated with functional connectivity in primary tauopathies

Author

Franzmeier, N, Brendel, M, Beyer, L, Slemann, L, Kovacs, GG, Arzberger, T, Kurz, C, Respondek, G, Lukic, MJ, Biel, D, Rubinski, A, Frontzkowski, L, Hummel, S, Muller, A, Finze, A, Palleis, C, Joseph, E, Weidinger, E, Katzdobler, S, Song, M, Biechele, G, Kern, M, Scheifele, M, Rauchmann, B-S, Perneczky, R, Rullman, M, Patt, M, Schildan, A, Barthel, H, Sabri, O, Rumpf, JJ, Schroeter, ML, Classen, J, Villemagne, V, Seibyl, J, Stephens, AW, Lee, EB, Coughlin, DG, Giese, A, Grossman, M, McMillan, CT, Gelpi, E, Molina-Porcel, L, Compta, Y, van Swieten, JC, Laat, LD, Troakes, C, Al-Sarraj, S, Robinson, JL, Xie, SX, Irwin, DJ, Roeber, S, Herms, J, Simons, M, Bartenstein, P, Lee, VM, Trojanowski, JQ, Levin, J, Hoeglinger, G, Ewers, M, Franzmeier, N, Brendel, M, Beyer, L, Slemann, L, Kovacs, GG, Arzberger, T, Kurz, C, Respondek, G, Lukic, MJ, Biel, D, Rubinski, A, Frontzkowski, L, Hummel, S, Muller, A, Finze, A, Palleis, C, Joseph, E, Weidinger, E, Katzdobler, S, Song, M, Biechele, G, Kern, M, Scheifele, M, Rauchmann, B-S, Perneczky, R, Rullman, M, Patt, M, Schildan, A, Barthel, H, Sabri, O, Rumpf, JJ, Schroeter, ML, Classen, J, Villemagne, V, Seibyl, J, Stephens, AW, Lee, EB, Coughlin, DG, Giese, A, Grossman, M, McMillan, CT, Gelpi, E, Molina-Porcel, L, Compta, Y, van Swieten, JC, Laat, LD, Troakes, C, Al-Sarraj, S, Robinson, JL, Xie, SX, Irwin, DJ, Roeber, S, Herms, J, Simons, M, Bartenstein, P, Lee, VM, Trojanowski, JQ, Levin, J, Hoeglinger, G, and Ewers, M

Abstract

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.

Published
2022

17. Desynchronization of microglial activity is closely associated with cognitive decline in Alzheimer’s disease

Author

Zatcepin, A., additional, Xiang, X., additional, Parhizkar, S., additional, Gnörich, J., additional, Grosch, M., additional, Wind, K., additional, Shi, Y., additional, Beyer, L., additional, Biechele, G., additional, Eckenweber, F., additional, Wiedemann, T., additional, Lindner, S., additional, Rominger, A., additional, Bartenstein, P., additional, Willem, M., additional, Tahirovic, S., additional, Herms, J., additional, Haass, C., additional, Ziegler, S., additional, and Brendel, M., additional

Published
2022
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19. MRI-based contrast clearance analysis shows high differentiation accuracy between radiation-induced reactions and progressive disease after cranial radiotherapy

Author

Bodensohn, R., primary, Forbrig, R., additional, Quach, S., additional, Reis, J., additional, Boulesteix, A.-L., additional, Mansmann, U., additional, Hadi, I., additional, Fleischmann, D.F., additional, Mücke, J., additional, Holzgreve, A., additional, Albert, N.L., additional, Ruf, V., additional, Dorostkar, M., additional, Corradini, S., additional, Herms, J., additional, Belka, C., additional, Thon, N., additional, and Niyazi, M., additional

Published
2022
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20. Biological-tumour-volumes in standard and early summation 18F-FET PET images distinctly exceed contrast-enhancement in patients with IDH-wildtype glioblastoma

Author

Unterrainer, M., additional, von Rohr, K., additional, Kaiser, L., additional, Ruf, V., additional, Holzgreve, A., additional, Unterrainer, L.M., additional, Brendel, M., additional, Kunz, W.G., additional, Herms, J., additional, Bartenstein, P., additional, Niyazi, M., additional, Tonn, J.C., additional, and Albert, N.L., additional

Published
2022
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21. Artificial Intelligence for early identification of Amyloid positivity in transgenic Alzheimer mice

Author

Eckenweber, F., additional, Eyring, L., additional, Krammer, S., additional, Krammer, C., additional, Li, Y., additional, Jakob, N., additional, Köhler, M., additional, Kunze, L., additional, Wind, K., additional, Beyer, L., additional, Biechele, G., additional, Lindner, S., additional, Gildehaus, F.J., additional, von Ungern-Sternberg, B., additional, Ziegler, S., additional, Boening, G., additional, Baumann, K., additional, Herms, J., additional, Bartenstein, P., additional, and Brendel, M., additional

Published
2022
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22. Prognostische Wertigkeit der TSPO-PET bei Patienten mit Gliomrezidiv

Author

Quach, S., additional, Holzgreve, A., additional, Kaiser, L., additional, Dekorsy, F.J., additional, Unterrainer, M., additional, Bartos, L.M., additional, Ruf, V.C., additional, Wetzel, C., additional, Herms, J., additional, Riemenschneider, M.J., additional, Rupprecht, R., additional, Brendel, M., additional, Thon, N., additional, von Baumgarten, L., additional, Bartenstein, P., additional, Tonn, J.C., additional, and Albert, N.L., additional

Published
2022
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23. Cell death in prion disease

Author

Ketzschmar, H. A., Giese, A., Brown, D. R., Herms, J., Keller, B., Schmidt, B., Groschup, M., Riederer, P., editor, Calne, D. B., editor, Horowski, R., editor, Mizuno, Y., editor, Poewe, W., editor, and Youdim, M. B. H., editor

Published
1997
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31. Remote Health Monitoring in the Workplace for Early Detection of COVID-19 Cases during the COVID-19 Pandemic Using a Mobile Health Application: COVIDApp

Author

Echeverría P, Puig J, Ruiz JM, Herms J, Sarquella M, Clotet B, and Negredo E

Subjects
workplace, remote health monitoring, COVID-19, early detection, health application
Abstract

Background: COVIDApp is a platform created for management of COVID-19 in the workplace. Methods: COVIDApp was designed and implemented for the follow-up of 253 workers from seven companies in Catalonia. The assessment was based on two actions: first, the early detection and management of close contacts and potential cases of COVID-19, and second, the rapid remote activation of protocols. The main objectives of this strategy were to minimize the risk of transmission of COVID-19 infection in the work area through a new real-time communication channel and to avoid unnecessary sick leave. The parameters reported daily by workers were close contact with COVID cases and signs and/or symptoms of COVID-19. Results: Data were recorded between 1 May and 30 November 2020. A total of 765 alerts were activated by 76 workers: 127 green alarms (16.6%), 301 orange alarms (39.3%), and 337 red alarms (44.1%). Of all the red alarms activated, 274 (81.3%) were activated for symptoms potentially associated with COVID-19, and 63 (18.7%) for reporting close contact with COVID-19 cases. Only eight workers (3.1%) presented symptoms associated with COVID-19 infection. All of these workers underwent RT-PCR tests, which yielded negative results for SARS-CoV2. Three workers were considered to have had a risk contact with COVID-19 cases; only 1 (0.4%) asymptomatic worker had a positive RT-PCR test result, requiring the activation of protocols, isolation, and contact tracing. Conclusions: COVIDApp contributes to the early detection and rapid activation of protocols in the workplace, thus limiting the risk of spreading the virus and reducing the economic impact caused by COVID-19 in the productive sector. The platform shows the progression of infection in real time and can help design new strategies.

Published
2021

32. Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

Author

Song, M, Beyer, L, Kaiser, L, Barthel, H, van Eimeren, T, Marek, K, Nitschmann, A, Scheifele, M, Palleis, C, Respondek, G, Kern, M, Biechele, G, Hammes, J, Bischof, G, Barbe, M, Onur, O, Jessen, F, Saur, D, Schroeter, ML, Rumpf, J-J, Rullmann, M, Schildan, A, Patt, M, Neumaier, B, Barret, O, Madonia, J, Russell, DS, Stephens, AW, Mueller, A, Roeber, S, Herms, J, Botzel, K, Danek, A, Levin, J, Classen, J, Hoglinger, GU, Bartenstein, P, Villemagne, V, Drzezga, A, Seibyl, J, Sabri, O, Boening, G, Ziegler, S, Brendel, M, Song, M, Beyer, L, Kaiser, L, Barthel, H, van Eimeren, T, Marek, K, Nitschmann, A, Scheifele, M, Palleis, C, Respondek, G, Kern, M, Biechele, G, Hammes, J, Bischof, G, Barbe, M, Onur, O, Jessen, F, Saur, D, Schroeter, ML, Rumpf, J-J, Rullmann, M, Schildan, A, Patt, M, Neumaier, B, Barret, O, Madonia, J, Russell, DS, Stephens, AW, Mueller, A, Roeber, S, Herms, J, Botzel, K, Danek, A, Levin, J, Classen, J, Hoglinger, GU, Bartenstein, P, Villemagne, V, Drzezga, A, Seibyl, J, Sabri, O, Boening, G, Ziegler, S, and Brendel, M

Abstract

The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.

Published
2021

40. [18F]PI-2620 Tau PET to Improve Imaging-Based Diagnosis of PSP

Author

Messerschmidt, K., Barthel, H., Brendel, M., Van Eimeren, T., Marek, K., Villemagne, V., Rumpf, J., Saur, D., Schroeter, M., Rullmann, M., Hoffmann, K., Scherlach, C., Rauchmann, B., Schildan, A., Patt, M., Beyer, L., Song, M., Palleis, C., Gehmeyr, M., Fietzek, U., Respondek, G., Sauerbeck, J., Nitschmann, A., Zach, C., Hammes, J., Barbe, M., Onur, O., Jessen, F., Neumaier, B., Barret, O., Madonia, J., Russell, D., Stephens, A., Roeber, S., Herms, J., Boetzel, K., Bartenstein, P., Levin, J., Drzezga, A., Seibyl, J., Hoeglinger, G., Classen, J., Sabri, O., Messerschmidt, K., Barthel, H., Brendel, M., Van Eimeren, T., Marek, K., Villemagne, V., Rumpf, J., Saur, D., Schroeter, M., Rullmann, M., Hoffmann, K., Scherlach, C., Rauchmann, B., Schildan, A., Patt, M., Beyer, L., Song, M., Palleis, C., Gehmeyr, M., Fietzek, U., Respondek, G., Sauerbeck, J., Nitschmann, A., Zach, C., Hammes, J., Barbe, M., Onur, O., Jessen, F., Neumaier, B., Barret, O., Madonia, J., Russell, D., Stephens, A., Roeber, S., Herms, J., Boetzel, K., Bartenstein, P., Levin, J., Drzezga, A., Seibyl, J., Hoeglinger, G., Classen, J., and Sabri, O.

Published
2020

41. Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy

Author

Brendel, M, Barthel, H, van Eimeren, T, Marek, K, Beyer, L, Song, M, Palleis, C, Gehmeyr, M, Fietzek, U, Respondek, G, Sauerbeck, J, Nitschmann, A, Zach, C, Hammes, J, Barbe, MT, Onur, O, Jessen, F, Saur, D, Schroeter, ML, Rumpf, J-J, Rullmann, M, Schildan, A, Patt, M, Neumaier, B, Barret, O, Madonia, J, Russell, DS, Stephens, A, Roeber, S, Herms, J, Boetzel, K, Classen, J, Bartenstein, P, Villemagne, V, Levin, J, Hoeglinger, GU, Drzezga, A, Seibyl, J, Sabri, O, Brendel, M, Barthel, H, van Eimeren, T, Marek, K, Beyer, L, Song, M, Palleis, C, Gehmeyr, M, Fietzek, U, Respondek, G, Sauerbeck, J, Nitschmann, A, Zach, C, Hammes, J, Barbe, MT, Onur, O, Jessen, F, Saur, D, Schroeter, ML, Rumpf, J-J, Rullmann, M, Schildan, A, Patt, M, Neumaier, B, Barret, O, Madonia, J, Russell, DS, Stephens, A, Roeber, S, Herms, J, Boetzel, K, Classen, J, Bartenstein, P, Villemagne, V, Levin, J, Hoeglinger, GU, Drzezga, A, Seibyl, J, and Sabri, O

Abstract

IMPORTANCE: Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future interventional trials against tau in PSP would strongly benefit from biomarkers that support diagnosis. OBJECTIVE: To investigate the potential of the novel tau radiotracer 18F-PI-2620 as a biomarker in patients with clinically diagnosed PSP. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, participants underwent dynamic 18F-PI-2620 positron emission tomography (PET) from 0 to 60 minutes after injection at 5 different centers (3 in Germany, 1 in the US, and 1 in Australia). Patients with PSP (including those with Richardson syndrome [RS]) according to Movement Disorder Society PSP criteria were examined together with healthy controls and controls with disease. Four additionally referred individuals with PSP-RS and 2 with PSP-non-RS were excluded from final data analysis owing to incomplete dynamic PET scans. Data were collected from December 2016 to October 2019 and were analyzed from December 2018 to December 2019. MAIN OUTCOMES AND MEASURES: Postmortem autoradiography was performed in independent PSP-RS and healthy control samples. By in vivo PET imaging, 18F-PI-2620 distribution volume ratios were obtained in globus pallidus internus and externus, putamen, subthalamic nucleus, substantia nigra, dorsal midbrain, dentate nucleus, dorsolateral, and medial prefrontal cortex. PET data were compared between patients with PSP and control groups and were corrected for center, age, and sex. RESULTS: Of 60 patients with PSP, 40 (66.7%) had RS (22 men [55.0%]; mean [SD] age, 71 [6] years; mean [SD] PSP rating scale score, 38 [15]; score range, 13-71) and 20 (33.3%) had PSP-non-RS (11 men [55.0%]; mean [SD] age, 71 [9] years; mean [SD] PSP rating scale score, 24 [11]; score range, 11-41). Ten healthy controls (2 men; mean [SD] age, 67 [7] years) and 20 controls with disease (of 10

Published
2020

44. Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease. (Inflammation and inflammatory bowel disease)

Author

Middel, P., Reich, K., Polzien, F., Blaschke, V., Hemmerlein, B., Herms, J., Korabiowska, M., and Radzun, H.J.

Subjects
Interleukins -- Physiological aspects, Crohn's disease -- Drug therapy, Health, Drug therapy, Physiological aspects
Abstract

Abstract Background--The mechanisms involved in the initiation and maintenance of Crohn's disease are poorly understood. Previous studies have demonstrated an increased number of infiltrating CD4+ T cells within the inflammatory [...]

Published
2001

45. PH-0359: Blood plasma based risk stratification of glioblastoma patients

Author

Fleischmann, D., primary, Unger, K., additional, Ruf, V., additional, Heider, T., additional, Hess, J., additional, Drexler, G., additional, Herms, J., additional, Thon, N., additional, Kreth, F., additional, Tonn, J., additional, Zitzelsberger, H., additional, Lauber, K., additional, Belka, C., additional, and Niyazi, M., additional

Published
2020
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46. OC-0322: 4-miRNA signature and MGMT promoter methylation improve risk stratification in glioblastoma.

Author

Unger, K., primary, Fleischmann, D.F., additional, Ruf, V., additional, Felsberg, J., additional, Piehlmaier, D., additional, Samaga, D., additional, Heß, J., additional, Mittelbronn, M., additional, Lauber, K., additional, Budach, W., additional, Sabel, M., additional, Rödel, C., additional, Reifenberger, G., additional, Herms, J., additional, Tonn, J., additional, Zitzelsberger, H., additional, Belka, C., additional, and Niyazi, M., additional

Published
2020
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47. Asymmetry of plaque burden in amyloid mouse models

Author

Beyer, L, additional, Sacher, C, additional, Blume, T, additional, Sauerbeck, J, additional, Eckenweber, F, additional, Focke, C, additional, Parhizkar, S, additional, Lindner, S, additional, Gildehaus, FJ, additional, von Ungern-Sternberg, B, additional, Neumann, U, additional, Baumann, K, additional, Tahirovic, S, additional, Kleinberger, G, additional, Willem, M, additional, Haass, C, additional, Bartenstein, P, additional, Rominger, A, additional, Herms, J, additional, and Brendel, M, additional

Published
2020
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48. Binding characteristics of 18 F-PI-2620 differentiate the clinically predicted tau isoform in suspected 3/4-repeat and 4-repeat tauopathies

Author

Song, M, additional, Barthel, H, additional, van Eimeren, T, additional, Marek, K, additional, Beyer, L, additional, Sauerbeck, J, additional, Barbe, M, additional, Schroeter, ML, additional, Russell, DS, additional, Stephens, A, additional, Herms, J, additional, Levin, J, additional, Classen, J, additional, Höglinger, G, additional, Bartenstein, P, additional, Villemagne, V, additional, Drzezga, A, additional, Seibyl, J, additional, Sabri, O, additional, and Brendel, M, additional

Published
2020
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50. 18 F-PI2620 Tau-PET in Progressive Supranuclear Palsy – A Multi-Center Evaluation

Author

Brendel, M, additional, Barthel, H, additional, van Eimeren, T, additional, Marek, K, additional, Beyer, L, additional, Song, M, additional, Sauerbeck, J, additional, Barbe, M, additional, Schroeter, ML, additional, Russell, DS, additional, Stephens, A, additional, Herms, J, additional, Levin, J, additional, Classen, J, additional, Höglinger, G, additional, Bartenstein, P, additional, Villemagne, V, additional, Drzezga, A, additional, Seibyl, J, additional, and Sabri, O, additional

Published
2020
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