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1. Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study

Author

Bögemann, S. A., Riepenhausen, A., Puhlmann, L. M. C., Bar, S., Hermsen, E. J. C., Mituniewicz, J., Reppmann, Z. C., Uściƚko, A., van Leeuwen, J. M. C., Wackerhagen, C., Yuen, K. S. L., Zerban, M., Weermeijer, J., Marciniak, M. A., Mor, N., van Kraaij, A., Köber, G., Pooseh, S., Koval, P., Arias-Vásquez, A., Binder, H., De Raedt, W., Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylińska, D., Veer, I. M., Kalisch, R., Hermans, E. J., and Walter, H.

Published
2023
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4. Prevalence of Rotational Malalignment After Infrapatellar Versus Suprapatellar Intramedullary Nailing of Tibial Shaft Fractures

Author

Alderlieste, D.S., Cain, Megan E., Gaast, N. van der, Verbakel, Joy, Edwards, B.H.J., Jaarsma, Emily H., Hermans, E., Edwards, M.J.R., Doornberg, Job N., Jaarsma, Ruurd L., Alderlieste, D.S., Cain, Megan E., Gaast, N. van der, Verbakel, Joy, Edwards, B.H.J., Jaarsma, Emily H., Hermans, E., Edwards, M.J.R., Doornberg, Job N., and Jaarsma, Ruurd L.

Abstract

Contains fulltext : 305679.pdf (Publisher’s version ) (Open Access)

Published
2024

7. Societal burden and quality of life in patients with Lisfranc Injuries

Author

van den Boom, N.A.C., primary, van den Hurk, A.A., additional, Evers, S.M.A.A., additional, Poeze, M., additional, Stollenwerck, G.A.N.L., additional, Schormans, P., additional, Schepers, T., additional, Hoogendoorn, J.M., additional, van den Boom, N.A.C., additional, Hermans, E., additional, Moumni, M.El, additional, Janzing, H., additional, van Vugt, R., additional, Van der Veen, A.H., additional, Theeuwes, H.P., additional, Van der Vlies, C.H., additional, and Kolkman, K.A., additional

Published
2023
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9. The STRESS-NL database

Author

Bonapersona, V., Born, F J, Bakvis, P, Branje, S, Elzinga, B, Evers, Awm, van Eysden, M, Fernandez, G, Habets, P C, Hartman, C A, Hermans, E J, Meeus, W, van Middendorp, H, Nelemans, S, Oei, N Y, Oldehinkel, A J, Roelofs, K, de Rooij, S R, Smeets, T, Tollenaar, M S, Joëls, M, Vinkers, C H, Leerstoel Branje, Adolescent development: Characteristics and determinants, Sub KGP, Sub General Pharmacology, Epidemiology and Data Science, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, Amsterdam Reproduction & Development (AR&D), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Ontwikkelingspsychologie (Psychologie, FMG), Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Medical and Clinical Psychology, Section Clinical Psychology, RS: FPN CPS III, Leerstoel Branje, Adolescent development: Characteristics and determinants, Sub KGP, and Sub General Pharmacology

Subjects
Male, 230 Affective Neuroscience, Databases, Factual, Hydrocortisone, Trier Social Stress Test, Acute stress test, IMPACT, Endocrinology, Diabetes and Metabolism, INDUCED CORTISOL ELEVATIONS, PSYCHOSOCIAL STRESS, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Experimental Psychopathology and Treatment, All institutes and research themes of the Radboud University Medical Center, Endocrinology, Human cortisol data, 130 000 Cognitive Neurology & Memory, Humans, BRAIN, ADAPTATION, Biological Psychiatry, SOCIAL STRESS, Netherlands, LIFE-SPAN, Endocrine and Autonomic Systems, MEMORY PERFORMANCE, HPA AXIS RESPONSES, Diabetes and Metabolism, Psychiatry and Mental health, Female, MINERALOCORTICOID RECEPTOR
Abstract

Contains fulltext : 249039.pdf (Publisher’s version ) (Open Access) Stress initiates a cascade of (neuro)biological, physiological, and behavioral changes, allowing us to respond to a challenging environment. The human response to acute stress can be studied in detail in controlled settings, usually in a laboratory environment. To this end, many studies employ acute stress paradigms to probe stress-related outcomes in healthy and patient populations. Though valuable, these studies in themselves often have relatively limited sample sizes. We established a data-sharing and collaborative interdisciplinary initiative, the STRESS-NL database, which combines (neuro)biological, physiological, and behavioral data across many acute stress studies in order to accelerate our understanding of the human acute stress response in health and disease (www.stressdatabase.eu). Researchers in the stress field from 12 Dutch research groups of 6 Dutch universities created a database to achieve an accurate inventory of (neuro)biological, physiological, and behavioral data from laboratory-based human studies that used acute stress tests. Currently, the STRESS-NL database consists of information on 5529 individual participants (2281 females and 3348 males, age range 6-99 years, mean age 27.7 ± 16 years) stemming from 57 experiments described in 42 independent studies. Studies often did not use the same stress paradigm; outcomes were different and measured at different time points. All studies currently included in the database assessed cortisol levels before, during and after experimental stress, but cortisol measurement will not be a strict requirement for future study inclusion. Here, we report on the creation of the STRESS-NL database and infrastructure to illustrate the potential of accumulating and combining existing data to allow meta-analytical, proof-of-principle analyses. The STRESS-NL database creates a framework that enables human stress research to take new avenues in explorative and hypothesis-driven data analyses with high statistical power. Future steps could be to incorporate new studies beyond the borders of the Netherlands; or build similar databases for experimental stress studies in rodents. In our view, there are major scientific benefits in initiating and maintaining such international efforts. 9 p.

Published
2022

11. The symmetry of the left and right tibial plateau: a comparison of 200 tibial plateaus.

Author

Gaast, Nynke van der, Dunning, H., Huitema, Jellina M., Waters, A., Jaarsma, R.L., Doornberg, J.N., Edwards, M.J.R., Groes, S.A.W. van de, Hermans, E., Gaast, Nynke van der, Dunning, H., Huitema, Jellina M., Waters, A., Jaarsma, R.L., Doornberg, J.N., Edwards, M.J.R., Groes, S.A.W. van de, and Hermans, E.

Abstract

01 februari 2023, Item does not contain fulltext, PURPOSE: This study aims to investigate the symmetry of the left and right tibial plateau in young healthy individuals to determine whether left-right mirroring can be reliably used to optimize preoperative 3D virtual planning for patients with tibial plateau fractures. METHODS: One hundred healthy subjects, without previous knee surgery, severe knee trauma, or signs of osteoarthritis were included for a previous dynamic imaging study of the knee. The subjects underwent a CT scan, scanning the left and right knee with a slice thickness of 0.8 mm. 3D surface models of the femur, patella, and tibia were created using a convolutional neural network. The 3D models of the left and right tibias were exported to MATLAB © and the tibias were mirrored. The mirrored tibias were superimposed on the contralateral tibia using a coherent point drift surface matching algorithm. Correspondence points on both surfaces were established, the mean root squared distance was calculated and visualized in a boxplot and heatmaps. RESULTS: The overall mean difference between correspondence points on the left and right tibial plateau is 0.6276 ± 0.0343 mm. The greatest differences between correspondence points were seen around two specific surfaces on the outside of the tibial plateau; where the distal tibia was cut 15 mm below the tibial plateau and around the tibiofibular joint. CONCLUSIONS: The differences between the left and right tibial plateau are small and therefore, we can be confident that the mirrored contralateral, unfractured, tibial plateau can be used as a template for 3D virtual preoperative planning for young patients without previous damage to the knee.

Published
2023

12. Quantifying the Differences between 3D Virtual Planning and Attained Postoperative Reduction on CT for Patients with Tibial Plateau Fractures; a Clinical Feasibility Study.

Author

Gaast, Nynke van der, Huitema, Jellina M., Edwards, B.H.J., Verbakel, Joy, Alderlieste, D.S., Doornberg, J.N., Edwards, M.J.R., Jaarsma, R.L., Hermans, E., Gaast, Nynke van der, Huitema, Jellina M., Edwards, B.H.J., Verbakel, Joy, Alderlieste, D.S., Doornberg, J.N., Edwards, M.J.R., Jaarsma, R.L., and Hermans, E.

Abstract

Item does not contain fulltext, Background: Three-Dimensional Virtual Planning (3DVP) has been proven to be effective for limiting intra-articular screw penetration and improving the quality of reduction for numerous fractures. However, the value of 3DVP for patients with tibial plateau fractures has yet to be determined. Purposes: The research question of this study is: Can Computed Tomography Micromotion Analysis (CTMA) provide a reliable quantification of the difference between 3DVP and the postoperative reduction on CT for tibial plateau fractures? Methods: Nine consecutive adult patients who received surgical treatment for a tibial plateau fracture and received pre- and postoperative CT scans were included from a level I trauma center in the Netherlands. The preoperative CT scans of the patients were uploaded in a 3DVP software. In this software, fracture fragments were reduced and the reduction was saved as a 3D file (STL). The quality of the reduction from the 3DVP software was compared with the postoperative results using CT Micromotion Analysis (CTMA). In this analysis, the translation of the largest intra-articular fragment was calculated by aligning the postoperative CT with the 3DVP. Coordinates and measurement points were defined in the X, Y, and Z axes. The combined values of X and Y were used to define the intra-articular gap. The Z-axis was defined as the line from cranial to caudal and was used to define intra-articular step-off. Results: The intra-articular step-off was 2.4 mm (Range 0.5-4.6). Moreover, the mean translation of the X-axis and Y-axis, which was defined as the intra-articular gap, was 4.2 mm (Range 0.6-10.7). Conclusions: 3DVP provides excellent insight into the fracture and its fragments. Utilizing the largest intra-articular fragment, it is feasible to quantify the difference between 3DVP and a postoperative CT using CTMA. A prospective study to further analyze the use of 3DVP in terms of intra-articular reduction and surgical and patient-related outcomes has been

Published
2023

13. Hip Function after Surgically Treated Isolated Traumatic Acetabular Fracture: A Prospective Series of Consecutive Cases.

Author

Smits, Indy G.M., Koenders, N.H.G., Stirler, V.M.A., Hermans, E., Smits, Indy G.M., Koenders, N.H.G., Stirler, V.M.A., and Hermans, E.

Abstract

01 juni 2023, Item does not contain fulltext, PURPOSE: Isolated acetabular fractures can occur as a result of a high energy impact on the hip joint. Surgery is required for most patients with an isolated acetabular fracture in order to alleviate pain, restore joint stability, and regain hip function. This study was conducted in order to examine the course of hip function in patients after surgical treatment of an isolated traumatic acetabular fracture. MATERIALS AND METHODS: This prospective series of consecutive cases included patients who underwent surgery for treatment of an isolated acetabular fracture in a European level one trauma center between 2016 and 2020. Patients with relevant concomitant injuries were excluded. Scoring of hip function was performed by a trauma surgeon using the Modified Merle d'Aubigné and Postel score at six-week, 12-week, six-month, and one-year follow-up. Scores between 3-11 indicate poor, 12-14 fair, 15-17 good, and 18 excellent hip function. RESULTS: Data on 46 patients were included. The mean score for hip function was 10 (95% confidence interval [CI] 7.09-12.91) at six-week follow-up (23 patients), 13.75 (95% CI 10.74-16.76) at 12-week follow-up (28 patients), 16 (95% CI 13.40-18.60) at six-month follow-up (25 patients), and 15.50 (95% CI 10.55-20.45) at one-year follow-up (17 patients). After one-year follow-up, the scores reflected an excellent outcome in 11 patients, good in five patients, and poor in one patient. CONCLUSION: This study reports on the course of hip function in patients who have undergone surgical treatment for isolated acetabular fractures. Restoration of excellent hip function takes six months.

Published
2023

14. Can CT-based gap and step-off displacement predict outcome after nonoperative treatment of acetabular fractures?

Author

Trouwborst, N.M., Duis, K. Ten, Banierink, H., Doornberg, J.N., Helden, S.H. van, Hermans, E., Lieshout, E.M.M. Van, Nijveldt, Robert, Tromp, T.N., Stirler, V.M.A., Verhofstad, M.H.J., Vries, J.P.P.M. de, Wijffels, M.M.E., Reininga, I.H.F., IJpma, F.F.A., Trouwborst, N.M., Duis, K. Ten, Banierink, H., Doornberg, J.N., Helden, S.H. van, Hermans, E., Lieshout, E.M.M. Van, Nijveldt, Robert, Tromp, T.N., Stirler, V.M.A., Verhofstad, M.H.J., Vries, J.P.P.M. de, Wijffels, M.M.E., Reininga, I.H.F., and IJpma, F.F.A.

Abstract

Contains fulltext : 296164.pdf (Publisher’s version ) (Open Access), AIMS: The aim of this study was to investigate the association between fracture displacement and survivorship of the native hip joint without conversion to a total hip arthroplasty (THA), and to determine predictors for conversion to THA in patients treated nonoperatively for acetabular fractures. METHODS: A multicentre cross-sectional study was performed in 170 patients who were treated nonoperatively for an acetabular fracture in three level 1 trauma centres. Using the post-injury diagnostic CT scan, the maximum gap and step-off values in the weightbearing dome were digitally measured by two trauma surgeons. Native hip survival was reported using Kaplan-Meier curves. Predictors for conversion to THA were determined using Cox regression analysis. RESULTS: Of 170 patients, 22 (13%) subsequently received a THA. Native hip survival in patients with a step-off ≤ 2 mm, > 2 to 4 mm, or > 4 mm differed at five-year follow-up (respectively: 94% vs 70% vs 74%). Native hip survival in patients with a gap ≤ 2 mm, > 2 to 4 mm, or > 4 mm differed at five-year follow-up (respectively: 100% vs 84% vs 78%). Step-off displacement > 2 mm (> 2 to 4 mm hazard ratio (HR) 4.9, > 4 mm HR 5.6) and age > 60 years (HR 2.9) were independent predictors for conversion to THA at follow-up. CONCLUSION: Patients with minimally displaced acetabular fractures who opt for nonoperative fracture treatment may be informed that fracture displacement (e.g. gap and step-off) up to 2 mm, as measured on CT images, results in limited risk on conversion to THA. Step-off ≥ 2 mm and age > 60 years are predictors for conversion to THA and can be helpful in the shared decision-making process.

Published
2023

15. The past, present and future of the conservative treatment of distal radius fractures.

Author

Bruijn, M.A.N. de, Ginkel, Laura A. van, Boersma, E.Z., Silfhout, L. van, Tromp, T.N., Krol, E. van de, Heijden, B.E.P.A. van der, Hermans, E., Stirler, V.M.A., Edwards, M.J.R., Bruijn, M.A.N. de, Ginkel, Laura A. van, Boersma, E.Z., Silfhout, L. van, Tromp, T.N., Krol, E. van de, Heijden, B.E.P.A. van der, Hermans, E., Stirler, V.M.A., and Edwards, M.J.R.

Abstract

Item does not contain fulltext, The distal radius fracture is a common fracture with a prevalence of 17% on the emergency departments. The conservative treatment of distal radius fractures usually consists of three to six weeks of plaster immobilization. Several studies show that one week of plaster immobilization is safe for non- or minimally displaced distal radius fractures that do not need reduction. A shorter period of immobilization may lead to a better functional outcome, faster reintegration and participation in daily activities. Due to upcoming innovations such as three-dimensional printed splints for distal radius fractures, a patient specific splint can be produced which may offer more comfort. Furthermore, these three-dimensional printed splints are expected to be more environmental friendly in comparison with traditional plaster casts.

Published
2023

16. Coping with COVID: risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, Walter, Henrik, Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, and Walter, Henrik

Abstract

Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M=2.45) and 2021 (M=2.21) were elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2023

21. Grade III blunt splenic injury without contrast extravasation - World Society of Emergency Surgery Nijmegen consensus practice

Author

Amico, F, Anning, R, Bendinelli, C, Balogh, Z, Leppaniemi, A, Aparicio-Sanchez, D, Hermans, E, Coccolini, F, Abu-Zidan, F, Chiarugi, M, Arvieux, C, Pirozzolo, G, Khokha, V, Tolonen, M, Edward, T, Sugrue, M, Ceresoli, M, Muhrbeck, M, Mohan, R, Piscioneri, F, Ietto, G, Chiara, O, Catena, F, Amico F., Anning R., Bendinelli C., Balogh Z. J., Leppaniemi A., Aparicio-Sanchez D., Hermans E., Coccolini F., Abu-Zidan F. M., Chiarugi M., Arvieux C., Pirozzolo G., Khokha V., Tolonen M., Edward T., Sugrue M., Ceresoli M., Muhrbeck M., Mohan R., Piscioneri F., Ietto G., Chiara O., Catena F., Amico, F, Anning, R, Bendinelli, C, Balogh, Z, Leppaniemi, A, Aparicio-Sanchez, D, Hermans, E, Coccolini, F, Abu-Zidan, F, Chiarugi, M, Arvieux, C, Pirozzolo, G, Khokha, V, Tolonen, M, Edward, T, Sugrue, M, Ceresoli, M, Muhrbeck, M, Mohan, R, Piscioneri, F, Ietto, G, Chiara, O, Catena, F, Amico F., Anning R., Bendinelli C., Balogh Z. J., Leppaniemi A., Aparicio-Sanchez D., Hermans E., Coccolini F., Abu-Zidan F. M., Chiarugi M., Arvieux C., Pirozzolo G., Khokha V., Tolonen M., Edward T., Sugrue M., Ceresoli M., Muhrbeck M., Mohan R., Piscioneri F., Ietto G., Chiara O., and Catena F.

Abstract

Background: Recent trauma guidelines recommend non-operative management for grade III splenic injury without contrast extravasation on computed tomography. Nevertheless, such recommendations rely on low-quality evidence, and practice variation characterizes clinical management for this type of injury. We aimed to identify the role of eleven selected clinical factors influencing the management of grade III splenic injury without contrast extravasation by expert consensus and a modified Delphi approach. Methods: A questionnaire was developed with the endorsement of the World Society of Emergency Surgery (WSES). This was delivered and answered live by acute care surgeons attending the 6th WSES congress in Nijmegen in 2019. A dedicated mobile phone application was utilized to collect the answers. All answers were evaluated for areas of discrepancy with an 80% threshold for consensus between respondents. Results: Three factors generated discrepancy in opinion for managing this pattern of injury: the patients' injury severity, the presence of a bleeding diathesis, and an associated intra-abdominal injury. Agreement was obtained for the other eight factors. Conclusion: Researchers should focus their efforts on the identified area of discrepancy. Clinicians should use additional care in the presence of the three factors for which discordant opinions were found.

Published
2020

22. Correction: Protocol of the Healthy Brain Study: An Accessible Resource for Understanding the Human Brain and How It Dynamically and Individually Operates in Its Bio-Social Context

Author

Healthy Brain Study consortium, Aarts, E, Akkerman, A, Altgassen, M, Bartels, R, Beckers, D, Bevelander, K, Bijleveld, E, Davidson, EB, Boleij, A, Bralten, J, Cillessen, T, Claassen, J, Cools, R, Cornelissen, I, Dresler, M, Eijsvogels, T, Faber, M, Fernández, G, Figner, B, Fritsche, M, Füllbrunn, S, Gayet, S, van Gelder, MMHJ, van Gerven, M, Geurts, S, Greven, CU, Groefsema, M, Haak, K, Hagoort, P, Hartman, Y, van der Heijden, B, Hermans, E, Heuvelmans, V, Hintz, F, den Hollander, J, Hulsman, AM, Idesis, S, Jaeger, M, Janse, E, Janzing, J, Kessels, RPC, Karremans, JC, de Kleijn, W, Klein, M, Klumpers, F, Kohn, N, Korzilius, H, Krahmer, B, de Lange, F, van Leeuwen, J, Liu, H, Luijten, M, Manders, P, Manevska, K, Marques, JP, Matthews, J, McQueen, JM, Medendorp, P, Melis, R, Meyer, A, Oosterman, J, Overbeek, L, Peelen, M, Popma, J, Postma, G, Roelofs, K, van Rossenberg, YGT, Schaap, G, Scheepers, P, Selen, L, Starren, M, Swinkels, DW, Tendolkar, I, Thijssen, DHJ, Timmerman, H, Tutunji, R, Tuladhar, A, Veling, H, Verhagen, M, Verkroost, J, Vink, J, Vriezekolk, V, Vrijsen, J, Vyrastekova, J, van der Wal, S, Willems, R, Willemsen, A, and Language, Communication and Cognition

Subjects
Questionnaires, Male, Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1], COVID-19/diagnosis, 230 Affective Neuroscience, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Social Sciences, Social Environment, 330 000 Food & Cognition, Social Development, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Analytical Chemistry, RC1200, Experimental Psychopathology and Treatment, Study Protocol, Cognition, Surveys and Questionnaires, 130 000 Cognitive Neurology & Memory, Affect/physiology, Medicine and Health Sciences, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Psychology, Public and Occupational Health, Cognition/physiology, Work, Health and Performance, Intelligence Tests, Grammar, Psycholinguistics, Multidisciplinary, Non-nativeness in Communication, Brain, 220 Statistical Imaging Neuroscience, 180 000 Predictive Brain, Cognitive artificial intelligence, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Semantics, Research Design, Medicine, Female, Behavioral and Social Aspects of Health, Institute for Management Research, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], Personality Tests, Adult, 110 000 Neurocognition of Language, Psychometrics, Science, Decision Making, Sensation, BF, Neuroimaging, Research and Analysis Methods, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Language and Speech, Learning and Therapy, QH301, All institutes and research themes of the Radboud University Medical Center, Humans, Speech Production and Comprehension, Sensation/physiology, 320 000 MR Structural Quantitative Imaging, Behavior, Survey Research, Behaviour Change and Well-being, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Neuro- en revalidatiepsychologie, Action, intention, and motor control, Neuropsychology and rehabilitation psychology, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Cognitive Psychology, Biology and Life Sciences, COVID-19, Linguistics, Brain/diagnostic imaging, QP, Language & Communication, Communication and Media, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Affect, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Narrative, Cognition & Communication, RC0321, Cognitive Science, Digital Security, 170 000 Motivational & Cognitive Control, Developmental Psychopathology, Neuroscience
Abstract

The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30–39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955.

Published
2022

23. Correction: Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

Author

Fernandez, G., Aarts, E., Akkerman, A., Altgassen, A.M., Bartels, R.H.M.A., Beckers, D.G.J., Bevelander, K.E., Bijleveld, E., Blaney Davidson, E.N., Boleij, A., Bralten, J.B., Cillessen, A.H.N., Claassen, J.A., Cools, R., Cornelissen, I.M.M., Dresler, M., Eijsvogels, T.M.H., Faber, M., Figner, B., Fritsche, M., Füllbrunn, S.C., Gayet, S., Gelder, M.M.H.J. van, Gerven, M.A.J. van, Geurts, S.A.E., Greven, C.U., Groefsema, M.M., Haak, K.V., Hagoort, P., Hartman, Y.A.W., Heijden, B.I.J.M. van der, Hermans, E., Heuvelmans, V.R., Hintz, F., Hollander, J.W. den, Hulsman, A.M., Idesis, S.A., Jaeger, Martin, Janse, E., Janzing, J.G., Kessels, R.P.C., Kleijn, W.P.E. de, Klein, M., Klumpers, F., Kohn, N., Korzilius, H.P.L.M., Krahmer, B., Lange, F.P. de, Leeuwen, J.M.C. van, Liu, H., Luijten, M., Manders, P., Manevska, K., Marques, J.P., Matthews, J., McQueen, J.M., Medendorp, W.P., Melis, R.J., Meyer, A.S., Oosterman, J.M., Overbeek, L.I.H., Peelen, M.V., Popma, J.A.M., Postma, G.J., Roelofs, K., Rossenberg, Y.G.T. van, Schaap, G.J., Scheepers, P.T., Selen, L.P.J., Starren, M.B.P., Swinkels, D.W., Tendolkar, I., Thijssen, D.H.J., Timmerman, H., Toutounji, R.T., Tuladhar, A.M., Veling, H.P., Verhagen, M., Verkroost, J., Vriezekolk, V., Vrijsen, J.N., Vyrastekova, J., Wal, S.E.I. van der, Willems, R.M., Willemsen, A.E.C.A.B., Fernandez, G., Aarts, E., Akkerman, A., Altgassen, A.M., Bartels, R.H.M.A., Beckers, D.G.J., Bevelander, K.E., Bijleveld, E., Blaney Davidson, E.N., Boleij, A., Bralten, J.B., Cillessen, A.H.N., Claassen, J.A., Cools, R., Cornelissen, I.M.M., Dresler, M., Eijsvogels, T.M.H., Faber, M., Figner, B., Fritsche, M., Füllbrunn, S.C., Gayet, S., Gelder, M.M.H.J. van, Gerven, M.A.J. van, Geurts, S.A.E., Greven, C.U., Groefsema, M.M., Haak, K.V., Hagoort, P., Hartman, Y.A.W., Heijden, B.I.J.M. van der, Hermans, E., Heuvelmans, V.R., Hintz, F., Hollander, J.W. den, Hulsman, A.M., Idesis, S.A., Jaeger, Martin, Janse, E., Janzing, J.G., Kessels, R.P.C., Kleijn, W.P.E. de, Klein, M., Klumpers, F., Kohn, N., Korzilius, H.P.L.M., Krahmer, B., Lange, F.P. de, Leeuwen, J.M.C. van, Liu, H., Luijten, M., Manders, P., Manevska, K., Marques, J.P., Matthews, J., McQueen, J.M., Medendorp, W.P., Melis, R.J., Meyer, A.S., Oosterman, J.M., Overbeek, L.I.H., Peelen, M.V., Popma, J.A.M., Postma, G.J., Roelofs, K., Rossenberg, Y.G.T. van, Schaap, G.J., Scheepers, P.T., Selen, L.P.J., Starren, M.B.P., Swinkels, D.W., Tendolkar, I., Thijssen, D.H.J., Timmerman, H., Toutounji, R.T., Tuladhar, A.M., Veling, H.P., Verhagen, M., Verkroost, J., Vriezekolk, V., Vrijsen, J.N., Vyrastekova, J., Wal, S.E.I. van der, Willems, R.M., and Willemsen, A.E.C.A.B.

Abstract

Contains fulltext : 248974.pdf (Publisher’s version ) (Open Access)

Published
2022

26. Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

Author

Scherpenzeel, M. van, Conte, F., Büll, C., Ashikov, A.M., Hermans, E., Willems, A.P., Tol, W. van, Kragt, E., Noga, M.J., Moret, E.E., Heise, Torben, Langereis, J.D., Rossing, E., Zimmermann, M., Rubio-Gozalbo, M.E., Jonge, M.I. de, Adema, G.J., Zamboni, N., Boltje, T.J., Lefeber, D.J., Scherpenzeel, M. van, Conte, F., Büll, C., Ashikov, A.M., Hermans, E., Willems, A.P., Tol, W. van, Kragt, E., Noga, M.J., Moret, E.E., Heise, Torben, Langereis, J.D., Rossing, E., Zimmermann, M., Rubio-Gozalbo, M.E., Jonge, M.I. de, Adema, G.J., Zamboni, N., Boltje, T.J., and Lefeber, D.J.

Abstract

Contains fulltext : 248778.pdf (Publisher’s version ) (Open Access)

Published
2022

27. A systematic review and meta-analyses on animal models used in bone adhesive research

Author

Erk, M. van, Luijk, J. van, Yang, F., Leeuwenburgh, S.C.G., Sánchez Fernández, M.J., Hermans, E., Felix Lanao, R.P., Goor, H. van, Erk, M. van, Luijk, J. van, Yang, F., Leeuwenburgh, S.C.G., Sánchez Fernández, M.J., Hermans, E., Felix Lanao, R.P., and Goor, H. van

Abstract

Item does not contain fulltext, Currently, steel implants are used for osteosynthesis of (comminuted) fractures and intra-articular bone defects. These osteosyntheses can sometimes be complicated procedures and can have several drawbacks including stress shielding of the bone. A bone glue might be a safe and effective alternative to current materials. Despite numerous animal studies on bone adhesives, no such material is clinically applied yet. We have conducted a systematic review to summarize the evidence in experimental animal models used in research on bone adhesive materials for trauma and orthopedic surgery. Additionally, we analysed the efficacy of the different bone adhesives for different experimental designs. A heterogeneity in experimental parameters including animal species, defect types, and control measurements resulted in a wide variety in experimental models. In addition, no standard outcome measurements could be identified. Meta-analysis on bone regeneration between adhesive treatment and nonadhesive treatment showed a high heterogeneity and no statistically significant overall effect (M: -0.71, 95% confidence interval [CI]: -1.63-0.21, p = 0.13). Besides, currently there is not enough evidence to draw conclusions based on the effectiveness of the individual types of adhesives or experimental models. A positive statistically significant effect was found for the adhesive treatment in comparison with conventional osteosynthesis materials (M: 2.49, 95% CI: 1.20-3.79, p = 0.0002). To enhance progression in bone adhesive research and provide valuable evidence for clinical application, more standard experimental parameters and a higher reporting quality in animal studies are needed. Statement of Clinical Significance: Current materials restoring anatomical alignments of bones have several drawbacks. A (biodegradable) adhesive for fixating bone defects can be a treatment breakthrough. Although numerous bone adhesives have been researched, most seemed to fail at the preclinical stage. An

Published
2022

28. Coping with COVID: risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, Walter, Henrik, Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, and Walter, Henrik

Abstract

Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M=2.45) and 2021 (M=2.21) were elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2022

31. The STRESS-NL database: A resource for human acute stress studies across the Netherlands

Author

Leerstoel Branje, Adolescent development: Characteristics and determinants, Sub KGP, Sub General Pharmacology, Bonapersona, V., Born, F J, Bakvis, P, Branje, S, Elzinga, B, Evers, Awm, van Eysden, M, Fernandez, G, Habets, P C, Hartman, C A, Hermans, E J, Meeus, W, van Middendorp, H, Nelemans, S, Oei, N Y, Oldehinkel, A J, Roelofs, K, de Rooij, S R, Smeets, T, Tollenaar, M S, Joëls, M, Vinkers, C H, Leerstoel Branje, Adolescent development: Characteristics and determinants, Sub KGP, Sub General Pharmacology, Bonapersona, V., Born, F J, Bakvis, P, Branje, S, Elzinga, B, Evers, Awm, van Eysden, M, Fernandez, G, Habets, P C, Hartman, C A, Hermans, E J, Meeus, W, van Middendorp, H, Nelemans, S, Oei, N Y, Oldehinkel, A J, Roelofs, K, de Rooij, S R, Smeets, T, Tollenaar, M S, Joëls, M, and Vinkers, C H

Published
2022

34. Grade III blunt splenic injury without contrast extravasation - World Society of Emergency Surgery Nijmegen consensus practice

Author

Amico, F., Anning, R., Bendinelli, C., Balogh, Z. J., Leppaniemi, A., Aparicio-Sanchez, D., Hermans, E., Coccolini, F., Abu-Zidan, F. M., Chiarugi, M., Arvieux, C., Pirozzolo, G., Khokha, V., Tolonen, M., Edward, T., Sugrue, M., Ceresoli, M., Muhrbeck, M., Mohan, R., Piscioneri, F., Ietto, G., Chiara, O., Catena, F., Amico, F, Anning, R, Bendinelli, C, Balogh, Z, Leppaniemi, A, Aparicio-Sanchez, D, Hermans, E, Coccolini, F, Abu-Zidan, F, Chiarugi, M, Arvieux, C, Pirozzolo, G, Khokha, V, Tolonen, M, Edward, T, Sugrue, M, Ceresoli, M, Muhrbeck, M, Mohan, R, Piscioneri, F, Ietto, G, Chiara, O, Catena, F, and HUS Abdominal Center

Subjects
Delphi Technique, IMPACT, Modified delphi, Contrast Media, Computed tomography, Injury, Wounds, Nonpenetrating, Injury Severity Score, 0302 clinical medicine, Surveys and Questionnaires, Acute care, Recent trauma, Contrast extravasation, 030212 general & internal medicine, Practice variation, medicine.diagnostic_test, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Blunt, Consensus, Grade III, Questionnaire, Spleen, Trauma, WSES, 3. Good health, Emergency Medicine, Research Article, medicine.medical_specialty, lcsh:Surgery, Consensu, 03 medical and health sciences, Emergency surgery, medicine, Humans, NONOPERATIVE MANAGEMENT, business.industry, 030208 emergency & critical care medicine, lcsh:RD1-811, lcsh:RC86-88.9, ADULTS, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, Bleeding diathesis, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], IV, Emergency medicine, Surgery, Tomography, X-Ray Computed, business
Abstract

Background Recent trauma guidelines recommend non-operative management for grade III splenic injury without contrast extravasation on computed tomography. Nevertheless, such recommendations rely on low-quality evidence, and practice variation characterizes clinical management for this type of injury. We aimed to identify the role of eleven selected clinical factors influencing the management of grade III splenic injury without contrast extravasation by expert consensus and a modified Delphi approach. Methods A questionnaire was developed with the endorsement of the World Society of Emergency Surgery (WSES). This was delivered and answered live by acute care surgeons attending the 6th WSES congress in Nijmegen in 2019. A dedicated mobile phone application was utilized to collect the answers. All answers were evaluated for areas of discrepancy with an 80% threshold for consensus between respondents. Results Three factors generated discrepancy in opinion for managing this pattern of injury: the patients’ injury severity, the presence of a bleeding diathesis, and an associated intra-abdominal injury. Agreement was obtained for the other eight factors. Conclusion Researchers should focus their efforts on the identified area of discrepancy. Clinicians should use additional care in the presence of the three factors for which discordant opinions were found.

Published
2020

35. Reelin cells and sex-dependent synaptopathology in autism following postnatal immune activation

Author

Quist A, Mallard C, Wegener G, Alabaf S, Gravina G, H.Rafati A, Shiadeh Smj, Hansen B, Westberg L, Ardalan M, Svedin P, Hermans E, and Chumak T

Subjects
Text mining, biology, business.industry, medicine, biology.protein, Autism, Reelin, medicine.disease, business, Neuroscience, Immune activation
Abstract

Autism Spectrum Disorders (ASD) are heterogeneous neurodevelopmental disorders with considerably increased risk in male infants born preterm and with neonatal infection. Here we investigated the role of postnatal immune activation on hippocampal synaptopathology by targeting Reelin+ cells in mice with ASD-like behavior. C57/Bl6 mouse pups of both sexes received lipopolysaccharide (LPS, 1mg/kg) on postnatal day (P) 5. At P45, animal behavior was examined by marble burying and sociability test, followed by ex-vivo brain MRI diffusion kurtosis imaging (DKI). Hippocampal synaptogenesis, number and morphology of Reelin+ cells, and mRNA expression of trans-synaptic genes, including neurexin-3, neuroligin-1, and cell-adhesion molecule nectin-1 were analyzed at P12 and P45. Social withdrawal and increased stereotypic activities in males were related to increased mean diffusivity on MRI-DKI and overgrowth in hippocampus together with retention of long-thin immature synapses on apical dendrites, decreased volume and number of Reelin+ cells as well as reduced expression of trans-synaptic and cell-adhesion molecules. The study provides new insights into sex-dependent mechanisms that may underlie ASD-like behavior in males following PIA. We identify GABAergic interneurons as core components of dysmaturation of excitatory synapses in the hippocampus following postnatal infection and provide cellular and molecular substrates for the MRI findings with translational value.

Published
2021

37. EOSC-Pillar - Roadmap for consolidating national initiatives

Author

Gaido L., Beckhmann V., Bodlos A., Candela L., Di Giorgio S., Hermans E., Honegger L., Quinteros J., Rouchon O., Van Wezel J., and Verlato M.

Subjects
EOSC, National Initiative
Abstract

The document sketches the status of the major National Initiatives and Mandated Organisations in the countries involved in EOSC-Pillar, i.e. Austria, Belgium, France, Germany and Italy, with the aim of identifying characteristics and peculiarities of each country, highlighting the points of strength and proposing a series of actions to consolidate them.

Published
2021

39. Self-regulation of stress-related large-scale brain network balance using real-time fMRI neurofeedback

Author

Krause, F., Kogias, N.O., Krentz, M., Lührs, M., Goebel, R., Hermans, E., Krause, F., Kogias, N.O., Krentz, M., Lührs, M., Goebel, R., and Hermans, E.

Abstract

Contains fulltext : 244087.pdf (Publisher’s version ) (Open Access), It has recently been shown that acute stress affects the allocation of neural resources between large-scale brain networks, and the balance between the executive control network and the salience network in particular. Maladaptation of this dynamic resource reallocation process is thought to play a major role in stress-related psychopathology, suggesting that stress resilience may be determined by the retained ability to adaptively reallocate neural resources between these two networks. Actively training this ability could hence be a potentially promising way to increase resilience in individuals at risk for developing stress-related symptomatology. Using real-time functional Magnetic Resonance Imaging, the current study investigated whether individuals can learn to self-regulate stress-related large-scale network balance. Participants were engaged in a bidirectional and implicit real-time fMRI neurofeedback paradigm in which they were intermittently provided with a visual representation of the difference signal between the average activation of the salience and executive control networks, and tasked with attempting to self-regulate this signal. Our results show that, given feedback about their performance over three training sessions, participants were able to (1) learn strategies to differentially control the balance between SN and ECN activation on demand, as well as (2) successfully transfer this newly learned skill to a situation where they (a) did not receive any feedback anymore, and (b) were exposed to an acute stressor in form of the prospect of a mild electric stimulation. The current study hence constitutes an important first successful demonstration of neurofeedback training based on stress-related large-scale network balance - a novel approach that has the potential to train control over the central response to stressors in real-life and could build the foundation for future clinical interventions that aim at increasing resilience.

Published
2021

40. Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

Author

Fernandez, G., Aarts, E., Akkerman, A., Altgassen, A.M., Bartels, R.H.M.A., Beckers, D.G.J., Bevelander, K.E., Bijleveld, E., Blaney Davidson, E.N., Boleij, A., Bralten, J.B., Cillessen, A.H.N., Claassen, J.A., Cools, R., Cornelissen, I.M.M., Dresler, M., Eijsvogels, T.M.H., Faber, M., Figner, B., Fritsche, M., Füllbrunn, S.C., Gayet, S., Gelder, M.M.H.J. van, Gerven, M.A.J. van, Geurts, S.A.E., Greven, C.U., Groefsema, M.M., Haak, K.V., Hagoort, P., Hartman, Y.A.W., Heijden, B.I.J.M. van der, Hermans, E., Heuvelmans, V.R., Hintz, F., Hollander, J.W. den, Hulsman, A.M., Idesis, S.A., Jaeger, Martin, Janse, E., Janzing, J.G., Kessels, R.P.C., Kleijn, W.P.E. de, Klein, M., Klumpers, F., Kohn, N., Korzilius, H.P.L.M., Krahmer, B., Lange, F.P. de, Leeuwen, J.M.C. van, Liu, H., Luijten, M., Manders, P., Manevska, K., Marques, J.P., Matthews, J., McQueen, J.M., Medendorp, W.P., Melis, R.J., Meyer, A.S., Oosterman, J.M., Overbeek, L.I.H., Peelen, M.V., Popma, J.A.M., Postma, G.J., Roelofs, K., Rossenberg, Y.G.T. van, Schaap, G.J., Scheepers, P.T., Selen, L.P.J., Starren, M.B.P., Swinkels, D.W., Tendolkar, I., Thijssen, D.H.J., Timmerman, H., Toutounji, R.T., Tuladhar, A.M., Veling, H.P., Verhagen, M., Verkroost, J., Vriezekolk, V., Vrijsen, J.N., Vyrastekova, J., Wal, S.E.I. van der, Willems, R.M., Willemsen, A.E.C.A.B., Fernandez, G., Aarts, E., Akkerman, A., Altgassen, A.M., Bartels, R.H.M.A., Beckers, D.G.J., Bevelander, K.E., Bijleveld, E., Blaney Davidson, E.N., Boleij, A., Bralten, J.B., Cillessen, A.H.N., Claassen, J.A., Cools, R., Cornelissen, I.M.M., Dresler, M., Eijsvogels, T.M.H., Faber, M., Figner, B., Fritsche, M., Füllbrunn, S.C., Gayet, S., Gelder, M.M.H.J. van, Gerven, M.A.J. van, Geurts, S.A.E., Greven, C.U., Groefsema, M.M., Haak, K.V., Hagoort, P., Hartman, Y.A.W., Heijden, B.I.J.M. van der, Hermans, E., Heuvelmans, V.R., Hintz, F., Hollander, J.W. den, Hulsman, A.M., Idesis, S.A., Jaeger, Martin, Janse, E., Janzing, J.G., Kessels, R.P.C., Kleijn, W.P.E. de, Klein, M., Klumpers, F., Kohn, N., Korzilius, H.P.L.M., Krahmer, B., Lange, F.P. de, Leeuwen, J.M.C. van, Liu, H., Luijten, M., Manders, P., Manevska, K., Marques, J.P., Matthews, J., McQueen, J.M., Medendorp, W.P., Melis, R.J., Meyer, A.S., Oosterman, J.M., Overbeek, L.I.H., Peelen, M.V., Popma, J.A.M., Postma, G.J., Roelofs, K., Rossenberg, Y.G.T. van, Schaap, G.J., Scheepers, P.T., Selen, L.P.J., Starren, M.B.P., Swinkels, D.W., Tendolkar, I., Thijssen, D.H.J., Timmerman, H., Toutounji, R.T., Tuladhar, A.M., Veling, H.P., Verhagen, M., Verkroost, J., Vriezekolk, V., Vrijsen, J.N., Vyrastekova, J., Wal, S.E.I. van der, Willems, R.M., and Willemsen, A.E.C.A.B.

Abstract

Contains fulltext : 242453.pdf (Publisher’s version ) (Open Access), The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods. https://www.trialregister.nl/trial/7955

Published
2021

42. The association between stress-induced changes in prefrontal GABA levels and heart rate variability: a 7T 1H-MRS study

Author

Kaiser, A., Reneman, L., Lucassen, P. J., Kaag, A. M., Van der Zwaag, W., Jurhar, T., Kirschbaum, C., Van den Heuvel, O. A., Hermans, E. J., Tan, H. L., Medical Microbiology and Infection Control, Radiology and nuclear medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Neurodegeneration, Physiology, and ACS - Heart failure & arrhythmias

Published
2020

48. Studies on treatment and outcome of pelvic fractures

Author

Hermans, E., Edwards, M.J.R., Goslings, J.C., Biert, J., Lansink, K.W.W, and Radboud University Nijmegen

Subjects
Radboud Institute for Molecular Life Sciences, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Reconstructive and regenerative medicine [Radboudumc 10]
Abstract

Contains fulltext : 201887.pdf (Publisher’s version ) (Open Access) Radboud University, 18 april 2019 Promotores : Edwards, M.J.R., Goslings, J.C. Co-promotores : Biert, J., Lansink, K.W.W

Published
2019

49. Increased responses of the reward circuitry to positive task feedback following acute stress in healthy controls but not in siblings of schizophrenia patients

Author

van Leeuwen, J M C, Vink, M., Joëls, M, Kahn, R S, Hermans, E J, Vinkers, C H, Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Afd Psychologische functieleer, Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Afd Psychologische functieleer, Psychiatry, Anatomy and neurosciences, and APH - Mental Health

Subjects
Male, IMPACT, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Striatum, Audiology, Brain mapping, 0302 clinical medicine, Trier social stress test, DOPAMINE RELEASE, ANTICIPATION, PUNISHMENT, Non-U.S. Gov't, RISK, Brain Mapping, Research Support, Non-U.S. Gov't, 05 social sciences, Brain, Schizophrenia/physiopathology, Stress, Psychological/physiopathology, DEPRESSION, Magnetic Resonance Imaging, Anticipation, medicine.anatomical_structure, Neurology, Psychological/physiology, Schizophrenia, Randomized Controlled Trial, ACTIVATIONS, psychological phenomena and processes, medicine.medical_specialty, Cognitive Neuroscience, NUCLEUS-ACCUMBENS, Brain/physiology, Nucleus accumbens, Stress, Research Support, 050105 experimental psychology, Feedback, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Reward, Journal Article, medicine, Humans, 0501 psychology and cognitive sciences, EXPOSURE, Anticipation, Psychological/physiology, Motivation, business.industry, Siblings, Ventral striatum, Psychological/physiopathology, Anticipation, Psychological, medicine.disease, Orbitofrontal cortex, GENDER, business, Stress, Psychological, 030217 neurology & neurosurgery
Abstract

Acute stress is known to affect the way we process rewards. For example, during, or directly after stress, activity within key brain areas of the reward circuitry is reduced when a reward is presented. Generally, the effects of stress on the brain are time-dependent, changing neural and cognitive processing in the aftermath of stress to aid recovery. Such a dynamic response to stress is important for resilience on the longer term. However, relatively little is known about reward processing during the recovery phase of stress and whether this is changed in individuals at increased risk for stress-related psychopathology.Healthy male individuals (N = 40) and unaffected siblings of schizophrenia patients (N = 40) were randomized to either an acute stress task (Trier Social Stress Test) or a no-stress task. Neural responses during reward anticipation and reward feedback (monetary gain or no gain) were examined 50 min later using an fMRI monetary incentive delay task. The ventral striatum and orbitofrontal cortex (OFC) were used as predefined hypothesis-driven regions of interest.Neural responses following stress differed between controls and siblings during reward feedback (group-stress interaction OFC p = 0.003, ventral striatum p = 0.031), showing increased ventral striatum and OFC responses following stress in healthy controls only. Exploratory analyses revealed that this effect was most pronounced during hit trials (compared to when a reward was omitted), and independent of monetary value. Stress did not affect subsequent reward processing in siblings of schizophrenia patients. We found no significant differences between controls and siblings in ventral striatum and OFC responses during reward anticipation following stress.This study shows that ventral striatum and OFC responses to positive task feedback are increased in the aftermath of stress in healthy male controls, regardless of monetary value. This indicates a dynamic shift from previously reported reduced responses in the striatum and OFC to reward feedback directly after stress to increased responses to both reward and non-reward feedback during the recovery phase of stress. These increased neural responses following stress were absent in siblings of schizophrenia patients. Together, these findings indicate that stress recovery is affected in this at-risk group, particularly in responses to positive feedback following stress.

Published
2019

50. Isolated iliac wing fractures : are they really that benign?

Author

Hermans, E., Edwards, M.J., and Biert, J.

Subjects
All institutes and research themes of the Radboud University Medical Center, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
Abstract

Contains fulltext : 219098.pdf (Publisher’s version ) (Closed access)

Published
2019

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