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2. Association among SNAP-25 Gene 'Dd'eI and 'Mnl'I Polymorphisms and Hemodynamic Changes during Methylphenidate Use: A Functional Near-Infrared Spectroscopy Study

Author

Oner, Ozgur, Akin, Ata, and Herken, Hasan

Abstract

Objective: To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS). Method: A total of 15 right-handed adults and 16 right-handed children with "DSM-IV" diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design. Results: Participants with SNAP-25 "Dd"eI T/T genotype had decreased right deoxyhemoglobin ([HHb]) with treatment. SNAP-25 "Mnl"I genotype was also associated with right deoxyhemoglobin ([HbO2]) and [HHb] changes as well as left [HHb] change. When the combinations of these genotypes were taken into account, the participants with ["Dd"eI C/C or T/C and "Mnl"I G/G or T/G] genotype had increased right [HHb] with MPH use whereas the participants with ["Dd"eI T/T and "Mnl"I T/T] or ["Dd"eI T/T and "Mnl"I G/G or T/G] genotypes had decreased right prefrontal [HHb]. Conclusions: These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants. (Contains 1 table and 4 figures.)

Published
2011
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33. High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study

Author

Celik Hakim, Savas Haluk, Bulut Mahmut, Selek Salih, Virit Osman, Erel Ozcan, and Herken Hasan

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Several studies indicate that elevated serum ceruloplasmin levels may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. No study investigating the relationship between ceruloplasmin and obsessive-compulsive disorder (OCD) has been published to date. Nowadays OCD is increasingly speculated to be a different disorder than other anxiety disorders, and rather is considered to be more similar to psychotic disorders. The objective of this study to explore whether there is an association of ceruloplasmin with OCD as in schizophrenia. Method 26 pure OCD and 9 co-morbid OCD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinics, diagnosed according to the DSM IV and 40 healthy controls were included in the study. Blood samples were collected; ceruloplasmin levels were measured. Results The mean ceruloplasmin level in pure OCD patients, co-morbid OCD patients, and control group persons were 544.46 ± 26.53, 424.43 ± 31.50 and 222.35 ± 8.88 U/L respectively. Results of all 3 groups differ significantly. Positive predictive value of ceruloplasmin for that cut-off point is 31/31 (100%) and negative predictive value is 40/44 (91%) in our group. Conclusion Although the nature of relationship is not clear there was an association between ceruloplasmin levels and OCD in our study.

Published
2008
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34. Association of the neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence

Author

Şengül,Cem., Erdal, M.E., Şengül Balcı,Ceyhan, Ay, O.I., Buber, A., Alaçam, Hüseyin., Ay, M.E., and Herken, Hasan.

Subjects
neuropeptide Y, integumentary system, alcoholism, genetic association, adult, genotype, Alcohol dependence, DNA determination, Neurexin, gene frequency, major clinical study, Article, neuropetide Y gene, female, male, single nucleotide polymorphism, controlled study, human, Polymorphism, gene, DNA extraction, neurexin 3 gene
Abstract

Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.

Published
2016

35. Relationship between the SNAP-25 gene and the effects of methylphenidate on the anterior cingulate cortex of patients with adult attention deficit hyperactivity disorder: A magnetic resonance spectroscopy study

Author

Ünal,Gonca Ayşe, Kenar, Ayşe Nur İnci, Tepeli, Emre, Kıroğlu, Yılmaz, and Herken, Hasan

Subjects
Adult, Magnetic Resonance Spectroscopy, genetic association, Synaptosomal-Associated Protein 25, genotype, SNAP25 protein, human, attention deficit disorder, methylphenidate, SNAP-25 gene, genetic analysis, Gyrus Cinguli, Article, N-acetylaspartate, analogs and derivatives, DSM-IV, male, Adult ADHD, choline, mental disorders, middle aged, genetic polymorphism, Humans, genetics, human, central stimulant agent, brain level, nuclear magnetic resonance spectroscopy, anterior cingulate, prefrontal cortex, Aspartic Acid, Polymorphism, Genetic, n acetylaspartic acid, cingulate gyrus, drug effect, SNAP 25 gene, Anterior cingulated cortex, major clinical study, creatine, female, nervous system, synaptosomal associated protein 25, Attention Deficit Disorder with Hyperactivity, drug metabolite, blood sampling, Central Nervous System Stimulants, human activities, metabolism
Abstract

Objective: The effects of certain genetic alterations in the brain function of patients with attention deficit hyperactivity disorder (ADHD) remain unclear and, in fact, there is a limited amount of data in this field. For example, the relationship between the SNAP-25 polymorphism and brain metabolites in response to methylphenidate (MPH) has yet to be investigated. Thus, the present study aimed to determine the relationship between changes in creatine (Cr), choline (Cho), and N-acetyl aspartate (NAA) levels in the prefrontal cortex (PFC) and anterior cingulate cortex (ACC) of adults with ADHD and the SNAP-25 gene polymorphism following the use of MPH. Patients and Methods: The present study assessed 60 patients between 18 and 60 years of age who were diagnosed with ADHD according to criteria from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Genetic analyses were carried out using blood samples obtained from the ADHD patients and included a detailed clinical evaluation for the SNAP-25 gene polymorphism. The NAA, Cr, and Cho levels in the ACC and PFC were measured using magnetic resonance spectroscopy (MRS). Following the evaluation, 10 mg of oral MPH was given to the patients, and the same metabolite levels were measured after 30 minutes. Results: The levels of NAA, Cr, and Cho in the PFC and ACC of patients with the SNAP-25 Ddel and Mnll polymorphism genotypes did not significantly differ before and after the administration of MPH. However, in patients with the SNAP-25 Ddel polymorphism T/T genotype and the Mnll polymorphism G/G genotype, there was a significant increase in NAA levels in the ACC after MPH treatment compared with before MPH treatment. Conclusion: The present results suggest that the SNAP-25 Ddel and Mnll polymorphisms might be associated with MPH-related changes in NAA levels in the ACC.

Published
2016

36. Brain-Derived Neurotrophic Factor Gene Va166Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample

Author

Ozturk, Onder, Basay, Burge Kabukcu, Buber, Ahmet, Basay, Omer, Alacam, Huseyin, Bacanli, Ali, Yilmaz, Senay Gorucu, Erdal, Mehmet Emin, Herken, Hasan, Ercan, Eyup Sabri, and Ege Üniversitesi

Subjects
Gene polymorphism, Attention-deficit hyperactivity disorder, Brain-derived neurotrophic factor
Abstract

WOS: 000384842300007, PubMed ID: 27757130, Objective Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that negatively affects different areas of life. We aimed to evaluate the associations between the Va166Met polymorphism of brain-derived neurotrophic factor (BDNF) and ADHD and to assess the effect of the BDNF polymorphism on the neurocognitive profile and clinical symptomatology in ADHD. Methods Two hundred one ADHD cases and 99 typically developing subjects (TD) between the ages of 8 and 15 years were involved in the study. All subjects were evaluated using a complete neuropsychological battery, Child Behavior Checklist, the Teacher's Report Form (TRF) and the DSM-IV Disruptive Behavior Disorders Rating Scale-teacher and parent forms. Results The GG genotype was significantly more frequent in the patients with ADHD than in the TD controls, and the GG genotype was also significantly more frequent in the ADHD-combined (ADHD-C) subtype patients than in the TDs. However, there were no significant associations of the BDNF polymorphism with the ADHD subtypes or neurocognitive profiles of the patients. The teacher-assessed hyperactivity and inattention symptom count and the total score were higher, and the appropriately behaving subtest score of the TRF was lower in the GG genotypes than in the GA and AA (i.e., the A-containing) genotypes. Conclusion We found a positive association between the BDNF gene Va166Met polymorphism and ADHD, and this association was observed specifically in the ADHD-C subtype and not the ADHD-predominantly inattentive subtype. Our findings support that the Va166Met polymorphism of BDNF gene might be involved in the pathogenesis of ADHD. Furthermore Va166Met polymorphism of BDNF gene may be more closely associated with hyperactivity rather than inattention.

Published
2016

41. The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients

Author

Başay,Ömer, Kabukçu Başay,Bürge, Alacam,Hüseyin, Öztürk,Önder, Büber,Ahmet, Yilmaz,Senay Gorucu, Kıroğlu,Yılmaz, Erdal,Mehmet Emin, Herken,Hasan, Başay,Ömer, Kabukçu Başay,Bürge, Alacam,Hüseyin, Öztürk,Önder, Büber,Ahmet, Yilmaz,Senay Gorucu, Kıroğlu,Yılmaz, Erdal,Mehmet Emin, and Herken,Hasan

Abstract

Ömer BaÅŸay,1 Burge Kabukcu Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Ahmet Buber,1 Senay Gorucu Yilmaz,3 Yılmaz KıroÄŸlu,4 Mehmet Emin Erdal,5 Hasan Herken2 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, 2Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, 3Department of Nutrition and Dietetics, Faculty of Health Sciences, Gaziantep University, Gaziantep, 4Department of Radiology, School of Medicine, Pamukkale University, Denizli, 5Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey Objective: To investigate the neurometabolite level changes according to synapsin III gene rs133945G>A and rs133946C>G polymorphisms by using magnetic resonance spectroscopy (MRS) in patients with attention-deficit hyperactivity disorder (ADHD).Methods: Fifty-seven adults diagnosed with ADHD were recruited for the study. The participants were examined by single-voxel 1H MRS when medication naïve and 30 minutes after oral administration of 10 mg methylphenidate (Mph). Those who had been on a stimulant discontinued the medication 48 hours before MRS imaging. Spectra were taken from the anterior cingulate cortex, dorsolateral prefrontal cortex, striatum, and cerebellum, and N-acetylaspartate (NAA), choline, and creatine levels were examined. For genotyping of the synapsin III gene polymorphisms, DNA was isolated from peripheral blood leukocytes. The effects of age, sex, and ADHD subtypes were controlled in the analyses.Results: After a single dose of Mph, choline levels increased significantly in the striatum of rs133945G>A polymorphism-GG genotypes (P=0.020) and NAA levels rose in the anterior cingulate cortex of rs133946C>G polymorphism-CG genotypes (P=0.014). Both rs133945G>A and rs133946C>G polymorphisms were found to statistically significantly affect the al

Published
2016

42. White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)

Author

Kabukçu Başay,Bürge, Büber,Ahmet, Başay,Ömer, Alacam,Hüseyin, Öztürk,Önder, Suren,Serkan, Izci Ay,Ozlem, Acikel,Cengizhan, Agladioglu,Kadir, Erdal,Mehmet Emin, Ercan,Eyup, Herken,Hasan, Kabukçu Başay,Bürge, Büber,Ahmet, Başay,Ömer, Alacam,Hüseyin, Öztürk,Önder, Suren,Serkan, Izci Ay,Ozlem, Acikel,Cengizhan, Agladioglu,Kadir, Erdal,Mehmet Emin, Ercan,Eyup, and Herken,Hasan

Abstract

Burge Kabukcu Basay,1 Ahmet Buber,1 Omer Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Serkan Suren,3 Ozlem Izci Ay,4 Cengizhan Acikel,5 Kadir Agladioglu,6 Mehmet Emin Erdal,4 Eyup Sabri Ercan,7 Hasan Herken21Child and Adolescent Psychiatry Department, Pamukkale University Medical Faculty, Denizli, 2Psychiatry Department, Pamukkale University Medical Faculty, Denizli, 3Medical Park Samsun Hospital, Samsun, 4Medical Biology and Genetics Department, Mersin University Medical Faculty, Mersin, 5Biostatistics Department, GATA (GMMA), Ankara, 6Radiology Department, Pamukkale University Medical Faculty, Denizli, 7Child and Adolescent Psychiatry Department, Ege University Medical Faculty, Izmir, TurkeyIntroduction: In this article, the COMT gene val158met polymorphism and attention-deficit hyperactivity disorder (ADHD)-related differences in diffusion-tensor-imaging-measured white matter (WM) structure in children with ADHD and controls were investigated.Patients and methods: A total of 71 children diagnosed with ADHD and 24 controls aged 8–15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA).Results: First, an interaction between the COMT val158met polymorphism and ADHD in the right (R) cingulum (cingulate gyrus) (CGC) was found. According to this, valine (val) homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the R-CGC than ADHD-diagnosed methionine (met) carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L)-uncinate fasciculus and lower RD in the L-posterior corona radiata and L-po

Published
2016

43. Lack of association between COMT gene polymorphism and treatment outcome in major depression

Author

SELEK, Salih, KAYA, Mehmet C., ERDAL, Mehmet Emin, BULUT, Mahmut, OZEN, Murat Eren, YUMRU, Mehmet, BARLAS, Ömer, KALENDEROGLU, Aysun, and HERKEN, Hasan

Subjects
mental disorders, behavioral disciplines and activities, KOMT Geni,antidepresan tedavi yanıtı,cinsiyet,major depresyon,polimorfizm
Abstract

Background & Aim: Abnormal activity of Catechol-O-methyl transferase (COMT), as a major degrading enzyme of catecholaminergic neurotransmitters may be enrolled in the pathogenesis of mood disorders. The aim of this study was to investigate the association between COMT genetic polymorphism and major depression patients. Method: The study included 137 unrelated major depressive disorder (MDD) patients and 153 healthy unrelated controls, all were of Turkish origin. The patients were treated with antidepressant drugs for 8 weeks. All patients were assessed by Hamilton Depression Rating Scale (HDRS) before and after the antidepressant treatment. The analysis of COMT G1947A polymorphism was performed using PCR based endonuclease digestion method. Results: No significant difference was found between MDD and control subjects. In the MDD patients, there was no relationship between duration of illness, and pretreatment HDRS scores in respect to COMT gene polymorphism. The distribution of COMT genotypes and alleles was not significantly different among the controls and MDD patients. Conclusion: Our findings indicated that distribution of COMT genetic polymorphism were not different significantly between the patients and controls. No allele was found to be a predictor for treatment outcome by antidepressant therapy or for clinical manifestations in MDD., Amaç: Katokolaminerjik nörotransmitter enzim yıkıcılarından Katekol-O-Metil Transferaz (KOMT)’ın anormal aktivitesi mizaç bozukluklarının patogenezinde rol oynayabilir. Bu çalışmanın amacı KOMT gen polimorfizmi ile major depresyon hastaları arasındaki ilişkiyi incelemektir. Yöntem: Çalışma, Türk kökenli 137 majör depresyon (MD) hastası ile 153 kontrolü içermektedir. Hastalar 8 hafta süreyle antidepresan tedavisi görmüştür. Bütün hastalar Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ) ile tedavi öncesi ve sonrası değerlendirilmiştir. COMT G1947A polimorfizmi PZR kökenli endonükleaz injesyon metdu ile yapılmıştır. Bulgular: MD hastaları ile kontroller arasında anlamlı bir fark bulunamamıştır. Hasta grubunda hastalık süresi ve tedavi öncesi HDDÖ skorları ile KOMT gen polimorfizmi arasında bağıntı bulunamamıştır. KOMT genotip ve alellerinin dağılımı hasta ve controller arasında anlamlı olarak farklı değildi. Sonuç: Bulgularımız KOMT gen polimorfizminin hasta ve controller arasında anlamlı olarak farklı olmadığını göstermiştir. MD’nin klinik görünüm ve antidepresan tedavisiyle ile ilişkili bir alel bulunamamıştır.

Published
2014

44. İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular

Author

Herken, Hasan

Subjects
iki uçlu bozukluk,tanı,tedavi,genetik
Abstract

s of the Speakers / Konuşmacı leri, Son yıllarda, psikiyatri alanındaki genetik çalışmalarve temel bilimlerdeki moleküler genetik ilerlemeler giderek hız kazanmaktadır. Klinik genetik çalışmalar göstermiştir ki, genetik bilgiler sadece iki uçlu bozukluğun etyolojisine değil, tedaviye yanıt ve ilaç yan etkilerini öngörmeye yönelik imkan ve fırsatlar sağlayabilme potansiyeline de sahiptir. Bu durum, hastalığın patofizyolojisini anlamakta büyük bir etkiye sahip olup patogenezinde rol oynayan genetik ve çevresel etmenler arasındaki etkileşimi araştırmak için önemli fırsatlar sunmaktadır. Bu gözden geçirme yazısında, iki uçlu bozukluğun mutasyonlar, kromozom bölgeleri ve genetiği ile tanı ve tedavisine yönelik yapılmış çalışmalar gözden geçirilmiştir.

Published
2014

45. Doktor Yazısıyla Aşk

Author

Dikkatli, Semih, Herken, Hasan, Hizli Sayar, Gokben, Üsküdar Üniversitesi NPSUAM, and TR25221

Published
2014

46. Risk of Psychotropic Drug Interactions in Real World Settings: a Pilot Study in Patients with Schizophrenia and Schizoaffective Disorder

Author

Sengul, Melike Ceyhan Balci, Karadağ, Filiz, Karakülah, Kamuran, Kalkancı, Özgür, Herken, Hasan, and Şengül, Cem

Subjects
Tıbbi İnformatik, Psikiyatri, Farmakoloji ve Eczacılık
Abstract

Amaç: Psikotik bozukluklarda giderek polifarmasi oranı artmaktadır. Polifarmasi eş zamanlı olarak iki veya daha fazla ilacın birlikte kullanımı olarak tanımlanmaktadır. Psikotrop ilaçların çoğu sitokrom enzim sistemi ile metabolize edildiği için polifarmasi uygulaması ile ilaçilaç etkileşim riskinin artacağı öngörülebilir. Bu çalışmada şizofreni ve şizoaffektif bozukluk tanısı konan hastalarda kullandıkları psikotrop ilaçlar arasındaki etkileşim riskinin incelenmesi amaçlanmıştır. Yöntem: Bu çalışmaya DSM-IV'e göre şizofreni ve şizoaffektif bozukluk tanısı konan, yatarak ya da poliklinikten takip olan, en az 12 haftadır antipsikotik alan 18-65 yaş arası hastalar alınmıştır. En az 4 haftadır eş zamanlı olarak kullanılan antipsikotik ve diğer psikotrop ilaçlar polifarmasi olarak kaydedildi. Etkileşim riskini tespit etmek için, her hastanın kullanmakta olduğu ilaçlar https://drugs.com adresine bireysel tedavi rejimi olarak girildikten sonra profesyonellere yönelik etkileşim bilgilerinden yararlanılarak araştırıldı.Bulgular: Çalışma grubu şizofreni spektrum bozukluğu (şizofreni, şizoaffektif bozukluk) olan 141 erkek (%58.80), 99 kadın (%41.20) toplam 240 hastadan oluşmaktaydı Tek antipsikotikle tedavi edilen hastaların oranı % 56.6 (s:136), iki veya daha fazla antipsikotik kullananların oranı %43.4 (s:104) idi. Kullanılan ortalama ilaç sayısı 2.58±1.22 (min 1-max 6), ortalama etkileşim sayısı 1.90±2.04 (min 1-max 10) olarak bulundu. Toplam 172 (%71.7) hasta etkileşim riski taşıyan ilaçları kullanmaktaydı, bu hastalarda toplam 417 ilaç etkileşimi riski mevcuttu. Etkileşim riskinin %87.8'i (toplam sayı 366) orta düzeyde idi. Hastaların yaklaşık dörtte biri (sayı 42, %24.4) major, 2 hasta (%1.2) minör ilaç etkileşim riski taşıyan ilaçları kullanmaktaydı. İlaç etkileşimlerinin olası sonuçları arasında ilk üç sırayı antikolinerjik yan etki riski, merkezi sinir sistemi ve solunum depresyonu riski ve QT uzaması riski yer almakta idi. Sonuç: Araştırmamız şizofreni spektrum bozukluklarında giderek artan çoklu ilaç kullanımı ile birlikte hastaların önemli bir kısmının ilaç-ilaç etkileşim riskiyle karşı karşıya olduğunu, bu etkileşim risklerinden major ilaç etkileşim riskinin büyük çoğunluğunun kardiovasküler riskler, özellikle de QT'de uzama riski olduğuna işaret etmektedir. Bu alanda ileriye dönük daha geniş vaka katılımlı çalışmalara ihtiyaç vardır

Published
2014

47. Neuropsychologic functions and soft neurologic signs in adult ADHD

Author

Kenar, Ayşe Nur İnci and Herken, Hasan

Subjects
Nörolojik Bilimler, Psikiyatri
Abstract

Amaç: Dikkat eksikliği hiperaktivite bozukluğu (DEHB), nöropsikiyatrik bir bozukluk olup etiyopatogenezinde frontostriatal döngü üzerinde durulmaktadır. Psikiyatrik bozukluklardaki beyin işlev bozukluklarının araştırılmasında kullanılan silik nörolojik belirtiler, daha çok çocukluk çağı DEHB"de araştırılmıştır. Bu çalışmada, erişkin DEHB"lilerin frontal bölge işlevlerine duyarlı nöropsikolojik test performansları ve silik nörolojik belirtilerin düzeylerinin araştırılması hedeflenmiştir. Yöntem: Çalışmaya DEHB tanısı konmuş olan 18-60 yaşları arasında 60 olgu ve 60 sağlıklı kontrol alındı. Her iki gruba Nörolojik Değerlendirme Ölçeği ve nöropsikolojik testler (Sayı dizileri, sözel bellek, Stroop ve Wisconsin Kart Eşleme Testi-WKET) uygulandı. Elli dokuz olgu ve 46 kontrol bireyinin nöropsikolojik testleri ve nörolojik değerlendirmesi geçerli kabul edilmiş ve istatistiksel değerlendirmeye alınmıştır. Sonuç: Erişkin DEHB grubunda sayı dizileri, sözel bellek ve stroop testlerinde kontrol grubuna göre anlamlı düzeyde düşük performans saptandı. WKET"de erişkin DEHB"liler ile kontrol grubu arasında farklılık bulunmadı. Silik nörolojik belirtilerde erişkin DEHB"lilerde motor koordinasyon ve alt test maddelerinden başparmak opozisyonunda kontrol grubuna göre anlamlı düzeyde düşük performans saptanmıştır. Erişkin DEHB"lilerde duyusal bütünleştirme alt testinde ve alt test maddelerinden işitsel görsel bütünleştirme ve söndürme testinde kontrol grubuna göre anlamlı düzeyde düşük performans saptanmıştır. ,,Diğer" alt testlerinden bellek, sinkinezi ve bakışı sabit tutma güçlüğü alt test maddelerinde erişkin DEHB"lilerde kontrol grubuna göre düşük performans saptanmıştır. Tartışma: DEHB"nin çocukluk çağında yaygın olduğu ve erişkin dönemde belirtilerin azaldığı belirtilmektedir. DEHB"de erişkinlikte de frontal lobda, serebellumda, pariyetal lobda ve/veya bunların birbirleriyle bağlantısını sağlayan fronto-striatal yolaklarda bir işlev bozukluğunun sürdüğü, bunun ise hastalığın gidişini ve tedaviyi etkileyebileceği düşünülmektedir.

Published
2014

48. The Effect of Single Dose Methylphenidate on Neurometabolites according to COMT Gene Val158Met Polymorphism in the Patient with Attention Deficit Hyperactivity Disorder: A Study Using Magnetic Resonance Spectroscopy

Author

Ozturk, Onder, primary, Alacam, Huseyin, additional, Basay, Burge Kabukcu, additional, Basay, Omer, additional, Buber, Ahmet, additional, Ay, Ozlem Izci, additional, Agladıoglu, Kadir, additional, Erdal, Mehmet Emin, additional, and Herken, Hasan, additional

Published
2016
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50. White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)

Author

Herken, Hasan, primary, Kabukçu Başay, Bürge, additional, Büber, Ahmet, additional, Başay, Ömer, additional, Alacam, Hüseyin, additional, Öztürk, Önder, additional, Suren, Serkan, additional, Izci Ay, Ozlem, additional, Agladioglu, Kadir, additional, Erdal, Mehmet Emin, additional, Ercan, Eyup, additional, and Acikel, Cengizhan, additional

Published
2016
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