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3. COVID-19: Auswirkungen auf das zentrale und periphere Nervensystem

Author

Ritschel, N., Radbruch, H., Stadelmann, Christine, Glatzel, M., Heppner, F. L., Weis, J., Sohrabi, K., Schänzer, A., Németh, A., Acker, T., „CNS-COVID19', DGNN-Taskforce, COVID-19', „DEFEAT PANDEMIcs- Neuropathologische Referenzdiagnostik bei, Herden, C., Pagenstecher, A., Schulz-Schaeffer, W., Stadelmann, C., Schneider, N., Dittmayer, C., Franz, J., Thomas, C., and Silva Boos, G.

Subjects
0301 basic medicine, Nervous system, medicine.medical_specialty, 2019-20 coronavirus outbreak, Registry, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Germany, Peripheral Nervous System, medicine, Humans, ddc:610, Schwerpunkt: COVID-19, Pandemics, Neuropathology, Gynecology, business.industry, SARS-CoV-2, Obduktion, COVID-19, Neuropathologie, Register, Nervensystem, 030104 developmental biology, medicine.anatomical_structure, Peripheral nervous system, Autopsy, business, 030217 neurology & neurosurgery
Abstract

The health effects of coronavirus disease 2019 (COVID-19) caused by the infection of SARS-CoV‑2 (severe acute respiratory syndrome coronavirus 2) are becoming increasingly clear as the pandemic spreads. In addition to the lungs, other organs are also affected, which can significantly influence morbidity and mortality. In particular, neurological symptoms involving the central nervous system can lead to acute or long-term consequences. The mechanisms of this neuropathogenesis of SARS-CoV‑2 infection and its relation to acute and chronic neurological symptoms are the subject of current studies investigating a potential direct and indirect viral infection of the nervous system. The following review summarizes the current status of neuropathological manifestations, molecular pathogenesis, possible infection pathways in the nervous system, and systemic effects. In addition, an overview of the Germany-wide CNS-COVID19 registry and collaborations is presented, which should contribute to a better understanding of the neurological symptoms of COVID-19.Die gesundheitlichen Auswirkungen der Coronavirus-Krankheit 2019 (COVID-19) durch die Infektion von SARS-CoV‑2 (Schweres-Akutes-Respiratorisches–Syndrom-Coronavirus 2) werden mit der Ausbreitung der Pandemie immer deutlicher. Neben der Lunge sind auch andere Organe betroffen, welche die Morbidität und Mortalität deutlich beeinflussen können. Insbesondere neurologische Symptome unter Beteiligung des zentralen und peripheren Nervensystems können akute Symptome oder Langzeitfolgen auslösen. Die Mechanismen dieser Neuropathogenese der SARS-CoV-2-Infektion und ihr Zusammenhang mit akuten und chronischen neurologischen Symptomen sind Gegenstand aktueller Studien, die sich mit der Untersuchung einer potenziellen direkten und indirekten Virusinfektion des Nervensystems beschäftigen. In der folgenden Übersichtsarbeit wird der aktuelle Stand über die neuropathologischen Manifestationen, die molekulare Pathogenese, die möglichen Infektionswege im Nervensystem und die systemischen Wirkungen zusammengefasst. Zusätzlich wird ein Überblick über das bundesweite Register CNS-COVID19 und Kooperationen gegeben, die zu einem besseren Verständnis der neurologischen Symptome von COVID-19 beitragen sollen.

Published
2021
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12. The continued need for animals to advance brain research

Author

Homberg, J.R., Adan, R.A., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., Dijk, G. Van, Eisel, U.L., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C.P., Dam, A.M.W. van, Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M.J., Nadif Kasri, N., Kiliaan, A.J., Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, K., Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejias, J.F., Meye, F.J., Mitchell, A.S., Mul, J.D., Olcese, U., González, A.O., Olivier, J.D., Pasqualetti, M., Pennartz, C.M.A., Popik, P., Prickaerts, J., Prida, L.M. de la, Ribeiro, S., Roozendaal, B., Rossato, J.I., Salari, A.A., Schoemaker, R.G., Smit, A.B., Vanderschuren, L., Takeuchi, T., Veen, R. van der, Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, M., Zee, E.A. van der, Genzel, L., Homberg, J.R., Adan, R.A., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., Dijk, G. Van, Eisel, U.L., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C.P., Dam, A.M.W. van, Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M.J., Nadif Kasri, N., Kiliaan, A.J., Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, K., Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejias, J.F., Meye, F.J., Mitchell, A.S., Mul, J.D., Olcese, U., González, A.O., Olivier, J.D., Pasqualetti, M., Pennartz, C.M.A., Popik, P., Prickaerts, J., Prida, L.M. de la, Ribeiro, S., Roozendaal, B., Rossato, J.I., Salari, A.A., Schoemaker, R.G., Smit, A.B., Vanderschuren, L., Takeuchi, T., Veen, R. van der, Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, M., Zee, E.A. van der, and Genzel, L.

Abstract

Item does not contain fulltext, Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

13. The continued need for animals to advance brain research

Author

University of Toronto, Homberg, J.R., Adan, R.A.H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., van Dijk, G., Eisel, U.L.M., Elgersma, Y., Englitz, B., Fernández-Ruiz, Antonio, Fitzsimons, C.P., van Dam, A.M., Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, Martien J. H., Kasri, N.N., Kiliaan, A.J, Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, Kirk, Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejías, Jorge F., Meye, F.J., Mitchell, A.S., Mul, J.D, Olcese, U., González, A.O., Olivier, Jocelien D.A., Pasqualetti, Massimo, Pennartz, Cyriel M.A., Popik, Piotr, Prickaerts, Jos, Menéndez de la Prida, Liset, Ribeiro, S., Roozendaal, B, Rossato, J.I., Salari, Ali-Akbar, Schoemaker, R.G., Smit, A.B., Vanderschuren, L.J.M.J., Takeuchi, T., van der Veen, Rixt, Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wo¨hr, M., Wolvekamp, M., van der Zee, E.A., Genzel, L., University of Toronto, Homberg, J.R., Adan, R.A.H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., van Dijk, G., Eisel, U.L.M., Elgersma, Y., Englitz, B., Fernández-Ruiz, Antonio, Fitzsimons, C.P., van Dam, A.M., Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, Martien J. H., Kasri, N.N., Kiliaan, A.J, Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, Kirk, Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejías, Jorge F., Meye, F.J., Mitchell, A.S., Mul, J.D, Olcese, U., González, A.O., Olivier, Jocelien D.A., Pasqualetti, Massimo, Pennartz, Cyriel M.A., Popik, Piotr, Prickaerts, Jos, Menéndez de la Prida, Liset, Ribeiro, S., Roozendaal, B, Rossato, J.I., Salari, Ali-Akbar, Schoemaker, R.G., Smit, A.B., Vanderschuren, L.J.M.J., Takeuchi, T., van der Veen, Rixt, Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wo¨hr, M., Wolvekamp, M., van der Zee, E.A., and Genzel, L.

Abstract

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

33. Distribution of zoonotic variegated squirrel bornavirus 1 in naturally infected variegated and Prevost’s squirrels

Author

Petzold, J. (Jana), Brand, J.M.A. (Judith) van den, Nobach, D. (Daniel), Hoffmann, B. (Bernd), Hoffmann, D. (Donata), Fast, C. (Christine), Reusken, C.B.E.M. (Chantal), Run, P.R.W.A. (Peter) van, Schlottau, K. (Kore), Beer, M. (Martin), Herden, C. (Christiane), Petzold, J. (Jana), Brand, J.M.A. (Judith) van den, Nobach, D. (Daniel), Hoffmann, B. (Bernd), Hoffmann, D. (Donata), Fast, C. (Christine), Reusken, C.B.E.M. (Chantal), Run, P.R.W.A. (Peter) van, Schlottau, K. (Kore), Beer, M. (Martin), and Herden, C. (Christiane)

Abstract

Recently, the zoonotic capacity of the newly discovered variegated squirrel bornavirus 1 (VSBV-1) was confirmed in humans with a lethal encephalitis. Transmission to humans occurred by variegated and Prevost’s squirrels as presumed reservoir hosts but possible ways of virus shedding and the route of infection still need to be elucidated. Thus, the tissue distribution of VSBV-1 antigen and RNA was investigated in detail via immunohistochemistry (IHC) in six variegated and eight Prevost’s squirrels and by in situ hybridisation (ISH) in one Prevost’s squirrel, respectively. VSBV-1 antigen and RNA positive cells were most numerous in the nervous system and were also found in nearly all tissues and different cell types indicating a broad organ and cell tropism of VSBV-1. Presence of VSBV-1 in several organs might indicate potential virus shedding via various routes and implies the risk of intra- and interspecies transmission, respectively.

Published
2019
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38. Atypical myopathy in two-humped camels

Author

Hirz, M., primary, Gregersen, H.A., additional, Czerwonka, N., additional, Sander, J., additional, Votion, D.M., additional, Schänzer, A., additional, Köhler, K., additional, and Herden, C., additional

Published
2019
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40. Genetic Variants in Kcnj10 and Atp1b2 in Malinois Puppies with Spongy Degeneration and Cerebellar Ataxia

Author

Högler, S., primary, Mauri, N., additional, Kleiter, M., additional, Leschnik, M., additional, Oevermann, A., additional, Henke, D., additional, Dietschi, E., additional, Wiedmer, M., additional, Dietrich, J., additional, Steffen, F., additional, Schuller, S., additional, Gurtner, C., additional, Stokar-Regenscheit, N., additional, O'Toole, D., additional, Bilzer, T., additional, Herden, C., additional, Jagannathan, V., additional, and Leeb, T., additional

Published
2018
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41. Variegated squirrel bornavirus 1 in squirrels, Germany and the Netherlands

Author

Schlottau, K. (Kore), Jenckel, M. (Maria), Brand, J.M.A. (Judith) van den, Fast, C. (Christine), Herden, C. (Christiane), Höper, D. (Dirk), Homeier-Bachmann, T. (Timo), Thielebein, J. (Jens), Mensing, N. (Niels), Diender, B. (Bert), Hoffmann, D. (Donata), Ulrich, R.G. (Rainer), Mettenleiter, T.C. (Thomas C.), Koopmans D.V.M., M.P.G. (Marion), Tappe, D. (Dennis), Schmidt-Chanasit, J. (Jonas), Reusken, C.B.E.M. (Chantal), Beer, M. (Martin), Hoffmann, B. (Bernd), Schlottau, K. (Kore), Jenckel, M. (Maria), Brand, J.M.A. (Judith) van den, Fast, C. (Christine), Herden, C. (Christiane), Höper, D. (Dirk), Homeier-Bachmann, T. (Timo), Thielebein, J. (Jens), Mensing, N. (Niels), Diender, B. (Bert), Hoffmann, D. (Donata), Ulrich, R.G. (Rainer), Mettenleiter, T.C. (Thomas C.), Koopmans D.V.M., M.P.G. (Marion), Tappe, D. (Dennis), Schmidt-Chanasit, J. (Jonas), Reusken, C.B.E.M. (Chantal), Beer, M. (Martin), and Hoffmann, B. (Bernd)

Abstract

We screened squirrels in Germany and the Netherlands for the novel zoonotic variegated squirrel bornavirus 1 (VSBV-1). The detection of VSBV-1 in 11 squirrels indicates a considerable risk for transmission to humans handling those animals. Therefore, squirrels in contact with humans should routinely be tested for VSBV-1.

Published
2017
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42. Variegated Squirrel Bornavirus 1 in Squirrels, Germany and the Netherlands

Author

Schlottau, K, Jenckel, M, van den Brand, Judith, Fast, C, Herden, C, Hoper, D, Homeier-Bachmann, L, Thielebein, J, Mensing, N, Diender, B, Hoffmann, D, Ulrich, RG, Mettenleiter, TC, Koopmans, Marion, Tappe, D, Schmidt-Chanasit, J, Reusken, Chantal, Beer, M, Hoffmann, B, Schlottau, K, Jenckel, M, van den Brand, Judith, Fast, C, Herden, C, Hoper, D, Homeier-Bachmann, L, Thielebein, J, Mensing, N, Diender, B, Hoffmann, D, Ulrich, RG, Mettenleiter, TC, Koopmans, Marion, Tappe, D, Schmidt-Chanasit, J, Reusken, Chantal, Beer, M, and Hoffmann, B

Published
2017

43. Neurotropic virus infections as the cause of immediate and delayed neuropathology

Author

Ludlow, M, Kortekaas, J, Herden, C, Hoffmann, B, Tappe, D, Trebst, C, Griffin, DE, Brindle, H E, Solomon, T, Brown, AS, van Riel, Debby, Wolthers, KC, Pajkrt, D, Wohlsein, P, Martina, Byron, Baumgartner, W, Verjans, Georges, Osterhaus, ADME, and Virology

Subjects
Neuroinfectiology, Flavivirus, Virus infection, Picornavirus, Clinical Neurology, Herpesvirus, Review, Alphavirus, Rhabdovirus, Bornavirus, Pathology and Forensic Medicine, Virology & Molecular Biology, Virologie & Moleculaire Biologie, Cellular and Molecular Neuroscience, Paramyxovirus, Central nervous system, Central Nervous System Viral Diseases, Animals, Humans, Bunyavirus, Influenza virus, Neuropathology
Abstract

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens. Electronic supplementary material The online version of this article (doi:10.1007/s00401-015-1511-3) contains supplementary material, which is available to authorized users.

Published
2016

44. Neuronal ceroid lipofuscinosis (NCL) is caused by the entire deletion of CLN8 in the Alpenländische Dachsbracke dog

Author

Hirz, M., primary, Drögemüller, M., additional, Schänzer, A., additional, Jagannathan, V., additional, Dietschi, E., additional, Goebel, H.H., additional, Hecht, W., additional, Laubner, S., additional, Schmidt, M.J., additional, Steffen, F., additional, Hilbe, M., additional, Köhler, K., additional, Drögemüller, C., additional, and Herden, C., additional

Published
2017
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46. Role of Lipocalin 2 in virally induced neuroinflammatory processes by the use of BDV-infected TNF-transgenic and TNF receptor k.o.-mice

Author

Vienenkoetter, J, Eisel, ULM, Culmsee, C, Hirz, M, and Herden, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective:Lipocalin 2 (Lcn 2) acts as a cytokine involved in the regulation of neuroinflammatory processes. It is supposed to promote classical proinflammatory activation of astrocytes and microglia via a TNFα- and NFκB-dependent TNFR1 mediated pathway [ref:1], [ref:2].[for full text, please go to the a.m. URL], 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Published
2015
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47. Cerebral alterations after multiple trauma and hemorrhagic shock

Author

Vogt, N, Eschbach, D, Herden, C, Uhl, E, Roeb, E, and Schöller, K

Subjects
hemorrhagic shock, ddc: 610, 610 Medical sciences, Medicine, multiple trauma, hypothermia
Abstract

Objective: Multiple trauma (MT) including hemorrhagic shock (HS) might lead to cerebral hypoperfusion and brain damage. Therefore, we studied the cerebral sequelae of polytrauma with tibia fracture, pulmonary contusion, liver laceration and controlled HS with subsequent reperfusion in a newly developed[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015
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48. Neurotropic virus infections as the cause of immediate and delayed neuropathology

Author

Ludlow, M. (Martin), Kortekaas, J. (Jeroen), Herden, C. (Christiane), Hoffmann, B. (Bernd), Tappe, D. (Dennis), Trebst, C. (Corinna), Griffin, D.E. (Diane E.), Brindle, H.E. (Hannah E.), Solomon, T. (Tom), Brown, A.S. (Alan S.), Riel, D.A.J. (Debby) van, Wolthers, K.C. (Katja), Pajkrt, D. (Dasja), Wohlsein, P. (Peter), Martina, B.E.E. (Byron), Baumgärtner, W. (Wolfgang), Verjans, G.M. (Georges M.), Osterhaus, A.D.M.E. (Albert), Ludlow, M. (Martin), Kortekaas, J. (Jeroen), Herden, C. (Christiane), Hoffmann, B. (Bernd), Tappe, D. (Dennis), Trebst, C. (Corinna), Griffin, D.E. (Diane E.), Brindle, H.E. (Hannah E.), Solomon, T. (Tom), Brown, A.S. (Alan S.), Riel, D.A.J. (Debby) van, Wolthers, K.C. (Katja), Pajkrt, D. (Dasja), Wohlsein, P. (Peter), Martina, B.E.E. (Byron), Baumgärtner, W. (Wolfgang), Verjans, G.M. (Georges M.), and Osterhaus, A.D.M.E. (Albert)

Abstract

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using exampl

Published
2016
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49. Neurotropic virus infections as the cause of immediate and delayed neuropathology

Author

Ludlow, M. (Martin), Kortekaas, J. (Jeroen), Herden, C. (Christiane), Hoffmann, B. (Bernd), Tappe, D. (Dennis), Trebst, C. (Corinna), Griffin, D.E. (Diane), Brindle, H.E. (Hannah), Solomon, T. (Tom), Brown, A.S. (Alan S.), Riel, D.A.J. (Debby) van, Wolthers, K.C. (Katja), Pajkrt, D. (Dasja), Wohlsein, P. (Peter), Martina, B.E.E. (Byron), Baumgärtner, W. (Wolfgang), Verjans, G.M.G.M. (George), Osterhaus, A.D.M.E. (Albert), Ludlow, M. (Martin), Kortekaas, J. (Jeroen), Herden, C. (Christiane), Hoffmann, B. (Bernd), Tappe, D. (Dennis), Trebst, C. (Corinna), Griffin, D.E. (Diane), Brindle, H.E. (Hannah), Solomon, T. (Tom), Brown, A.S. (Alan S.), Riel, D.A.J. (Debby) van, Wolthers, K.C. (Katja), Pajkrt, D. (Dasja), Wohlsein, P. (Peter), Martina, B.E.E. (Byron), Baumgärtner, W. (Wolfgang), Verjans, G.M.G.M. (George), and Osterhaus, A.D.M.E. (Albert)

Abstract

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delay

Published
2015

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