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2. The Oxygen Cascade According to HFpEF Likelihood: A Focus on Sex Differences.

Author

Verwerft, J, Foulkes, S, Bekhuis, Y, Moura-Ferreira, S, Falter, M, Hoedemakers, S, Jasaityte, R, Stassen, J, Herbots, L, La Gerche, A, Haykowsky, MJ, Claessen, G, Verwerft, J, Foulkes, S, Bekhuis, Y, Moura-Ferreira, S, Falter, M, Hoedemakers, S, Jasaityte, R, Stassen, J, Herbots, L, La Gerche, A, Haykowsky, MJ, and Claessen, G

Abstract

BACKGROUND: Women are at greater risk for heart failure with preserved ejection fraction (HFpEF). OBJECTIVES: The aim of the study was to compare sex differences in the pathophysiology of exertional breathlessness in patients with high vs low HFpEF likelihood. METHODS: This cohort study evaluated consecutive patients (n = 1,936) with unexplained dyspnea using cardiopulmonary exercise testing and simultaneous echocardiography and quantified peak oxygen uptake (peak VO2) and its determinants. HFpEF was considered likely when the H2FPEF or HFA-PEFF score was ≥6 or ≥5, respectively. Sex differences were evaluated with the Student's t-test or Mann-Whitney U test and determinants of exercise capacity with a multivariable linear regression. RESULTS: The cohort included 1,963 patients (49% women and 28% [n = 555] with a high HFpEF likelihood). HFpEF likelihood did not impact the magnitude of sex differences in peak VO2 and its determinants. Overall, women had lower peak VO2 (mean difference -4.4 mL/kg/min [95% CI: -3.7 to -5.1 mL/kg/min]) secondary to a reduced O2 delivery (-0.5 L/min [95% CI: -0.4 to -0.6 L/min]) and less oxygen extraction (-2.9 mL/dL [95% CI: -2.5 to -3.2 mL/dL]). Reduced O2 delivery was due to lower hemoglobin (-1.2 g/dL [95% CI: -0.9 to -1.5 g/dL]) and smaller stroke volume (-15 mL [95% CI: -14 to -17 mL]). Women demonstrated increased mean pulmonary artery pressure/cardiac output slope (+0.5 mm Hg/L/min [95% CI: 0.3-0.7 mm Hg/L/min]) and left ventricular ejection fraction (+1% [95% CI: 1%-2%]), while they had smaller left ventricular end-diastolic volumes (-9 mL/m2 [95% CI: -8 to -11 mL/m2]) and mass (-12 g/m2 [95% CI: -9 to -14 g/m2]) and more often iron deficiency (55% vs 33%; P < 0.001). CONCLUSIONS: Women with unexplained dyspnea had significantly lower peak VO2, regardless of HFpEF likelihood, attributed to both lower peak exercise O2 delivery and extraction. This suggests that physiologic sex differences, and not HFpEF likelihood, are an importan

Published
2024

5. Lifelong endurance exercise and its relation with coronary atherosclerosis

Author

De Bosscher, R, Dausin, C, Claus, P, Bogaert, J, Dymarkowski, S, Goetschalckx, K, Ghekiere, O, Van De Heyning, CM, Van Herck, P, Paelinck, B, El Addouli, H, La Gerche, A, Herbots, L, Willems, R, Heidbuchel, H, Claessen, G, Claeys, M, Hespel, P, Dresselaers, T, Miljoen, H, Belmans, A, Favere, Kasper, Vermeulen, D, Witvrouwen, I, Hansen, D, Eijnde, Bert Op't, Thijs, D, Vanvoorden, P, Van Soest, S, Master@Heart, Consortium, Master@Heart Consortium, Willems, Rik/0000-0002-5469-9609, Dausin, Christophe/0000-0001-7864-2968, Van de Heyning, Caroline/0000-0002-4661-4732, De Bosscher, Ruben, Dausin, Christophe, Claus, Piet, Bogaert, Jan, Dymarkowski, Steven, Goetschalckx, Kaatje, GHEKIERE, Olivier, van de Heyning, Caroline M., Van Herck, Paul, Paelinck, Bernard, El Addouli, Haroun, La Gerche, Andre, HERBOTS, Lieven, Willems , Rik, HEIDBUCHEL, Hein, CLAESSEN, Guido, Claeys, Mathias, Hespel, Peter, Dresselaers, Tom, Miljoen, Hielko, Belmans, Ann, Favere, Kasper, Vermeulen, Dorien, Witvrouwen, Isabel, HANSEN, Dominique, OP 'T EIJNDE, Bert, Thijs, Daisy, Vanvoorden, Peter, and Van Soest , Sofie

Subjects
Medicine and Health Sciences, Athlete's heart, Human medicine, Athlete’s heart, Cardiology and Cardiovascular Medicine, Coronary artery disease, Exercise, Computed tomography coronary angiography
Abstract

Aims The impact of long-term endurance sport participation (on top of a healthy lifestyle) on coronary atherosclerosis and acute cardiac events remains controversial. Methods and results The Master@Heart study is a well-balanced prospective observational cohort study. Overall, 191 lifelong master endurance athletes, 191 late-onset athletes (endurance sports initiation after 30 years of age), and 176 healthy non-athletes, all male with a low cardiovascular risk profile, were included. Peak oxygen uptake quantified fitness. The primary endpoint was the prevalence of coronary plaques (calcified, mixed, and non-calcified) on computed tomography coronary angiography. Analyses were corrected for multiple cardiovascular risk factors. The median age was 55 (50-60) years in all groups. Lifelong and late-onset athletes had higher peak oxygen uptake than non-athletes [159 (143-177) vs. 155 (138-169) vs. 122 (108-138) % predicted]. Lifelong endurance sports was associated with having >= 1 coronary plaque [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.17-2.94], >= 1 proximal plaque (OR 1.96, 95% CI 1.24-3.11), >= 1 calcified plaques (OR 1.58, 95% CI 1.01-2.49), >= 1 calcified proximal plaque (OR 2.07, 95% CI 1.28-3.35), >= 1 non-calcified plaque (OR 1.95, 95% CI 1.12-3.40), >= 1 non-calcified proximal plaque (OR 2.80, 95% CI 1.39-5.65), and >= 1 mixed plaque (OR 1.78, 95% CI 1.06-2.99) as compared to a healthy non-athletic lifestyle. Conclusion Lifelong endurance sport participation is not associated with a more favourable coronary plaque composition compared to a healthy lifestyle. Lifelong endurance athletes had more coronary plaques, including more non-calcified plaques in proximal segments, than fit and healthy individuals with a similarly low cardiovascular risk profile. Longitudinal research is needed to reconcile these findings with the risk of cardiovascular events at the higher end of the endurance exercise spectrum. [GRAPHICS] . This study is supported by a research grant (T003717N) and R.W. is supported as a post-doctoral clinical researcher by the Fund for Scientific Research Flanders (FWO Vlaanderen), Brussels, Belgium The authors would like to thank the many staff members at the three sites for helping conduct this study. We would particularly like to thank the clinical research assistants Sofie van Soest, Dorien Vermeulen, and Daisy Thijs for their dedication and devoted efforts to include, test, and follow up participants. We would like to thank Ann Belmans for calculating the sample size and statistical advice. We would also like to thank Kris Van der Mieren (Sport- en keuringsartsen), Tom Teuglinckx (Sport- en keuringsartsen), Reynout Van Schuylenbergh (Triatlon Vlaanderen), Frank Glorieux (Cycling Vlaanderen), Paul Rowe (Sport Vlaanderen), Gert Van Goolen (Golazo), and Sven Nys (Golazo and godfather of Master@Heart) as members of the advisory committee for their insightful input on the design, the launch, and approach of the Master@Heart study.

Published
2023

8. Rationale and design of the PROspective ATHletic Heart (Pro@Heart) study: long-term assessment of the determinants of cardiac remodelling and its clinical consequences in endurance athletes

Author

De Bosscher, R, Dausin, C, Janssens, K, Bogaert, J, Elliott, A, Ghekiere, O, Van De Heyning, CM, Sanders, P, Kalman, J, Fatkin, D, Herbots, L, Willems, R, Heidbuchel, H, La Gerche, A, Claessen, G, De Bosscher, R, Dausin, C, Janssens, K, Bogaert, J, Elliott, A, Ghekiere, O, Van De Heyning, CM, Sanders, P, Kalman, J, Fatkin, D, Herbots, L, Willems, R, Heidbuchel, H, La Gerche, A, and Claessen, G

Abstract

BACKGROUND: Exercise-induced cardiac remodelling (EICR) results from the structural, functional and electrical adaptations to exercise. Despite similar sports participation, EICR varies and some athletes develop phenotypic features that overlap with cardiomyopathies. Training load and genotype may explain some of the variation; however, exercise 'dose' has lacked rigorous quantification. Few have investigated the association between EICR and genotype. OBJECTIVES: (1) To identify the impact of training load and genotype on the variance of EICR in elite endurance athletes and (2) determine how EICR and its determinants are associated with physical performance, health benefits and cardiac pathology. METHODS: The Pro@Heart study is a multicentre prospective cohort trial. Three hundred elite endurance athletes aged 14-23 years will have comprehensive cardiovascular phenotyping using echocardiography, cardiac MRI, 12-lead ECG, exercise-ECG and 24-hour-Holter monitoring. Genotype will be determined using a custom cardiomyopathy gene panel and high-density single-nucleotide polymorphism arrays. Follow-up will include online tracking of training load. Cardiac phenotyping will be repeated at 2, 5, 10 and 20 years. RESULTS: The primary endpoint of the Pro@Heart study is the association of EICR with both training load and genotype. The latter will include rare variants in cardiomyopathy-associated genes and polygenic risk scores for cardiovascular traits. Secondary endpoints are the incidence of atrial and ventricular arrhythmias, physical performance and health benefits and their association with training load and genotype. CONCLUSION: The Pro@Heart study is the first long-term cohort study to assess the impact of training load and genotype on EICR. TRIAL REGISTRATION NUMBER: NCT05164328; ACTRN12618000716268.

Published
2022

9. The prevalence and clinical significance of a reduced ventricular ejection fraction in asymptomatic young elite endurance athletes

Author

De Bosscher, R, primary, Janssens, K, additional, Dausin, C, additional, Goetschalckx, K, additional, Bogaert, J, additional, Ghekiere, O, additional, Van De Heyning, C, additional, Elliott, A, additional, Sanders, P, additional, Kalman, J, additional, Herbots, L, additional, Willems, R, additional, Heidbuchel, H, additional, La Gerche, A, additional, and Claessen, G, additional

Published
2022
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10. Endurance exercise and the risk of cardiovascular pathology in men: a comparison between lifelong and late-onset endurance training and a non-athletic lifestyle-rationale and design of the Master@Heart study, a prospective cohort trial

Author

De Bosscher, R, Dausin, C, Claus, P, Bogaert, J, Dymarkowski, S, Goetschalckx, K, Ghekiere, O, Belmans, A, Van de Heyning, CM, Van Herck, P, Paelinck, B, El Addouli, H, La Gerche, A, Herbots, L, Heidbuchel, H, Willems, R, Claessen, G, De Bosscher, R, Dausin, C, Claus, P, Bogaert, J, Dymarkowski, S, Goetschalckx, K, Ghekiere, O, Belmans, A, Van de Heyning, CM, Van Herck, P, Paelinck, B, El Addouli, H, La Gerche, A, Herbots, L, Heidbuchel, H, Willems, R, and Claessen, G

Abstract

INTRODUCTION: Low and moderate endurance exercise is associated with better control of cardiovascular risk factors, a decreased risk of coronary artery disease and atrial fibrillation (AF). There is, however, a growing proportion of individuals regularly performing strenuous and prolonged endurance exercise in which the health benefits have been challenged. Higher doses of endurance exercise have been associated with a greater coronary atherosclerotic plaque burden, risk of AF and myocardial fibrosis (MF). METHODS AND ANALYSIS: Master@Heart is a multicentre prospective cohort study aiming to assess the incidence of coronary atherosclerosis, AF and MF in lifelong endurance athletes compared to late-onset endurance athletes (initiation of regular endurance exercise after the age of 30 years) and healthy non-athletes.The primary endpoint is the incidence of mixed coronary plaques. Secondary endpoints include coronary calcium scores, coronary stenosis >50%, the prevalence of calcified and soft plaques and AF and MF presence. Tertiary endpoints include ventricular arrhythmias, left and right ventricular function at rest and during exercise, arterial stiffness and carotid artery intima media thickness.Two hundred male lifelong athletes, 200 late-onset athletes and 200 healthy non-athletes aged 45-70 will undergo comprehensive cardiovascular phenotyping using CT, coronary angiography, echocardiography, cardiac MRI, 12-lead ECG, exercise ECG and 24-hour Holter monitoring at baseline. Follow-up will include online tracking of sports activities, telephone calls to assess clinical events and a 7-day ECG recording after 1 year. ETHICS AND DISSEMINATION: Local ethics committees approved the Master@Heart study. The trial was launched on 18 October 2018, recruitment is complete and inclusions are ongoing. TRIAL REGISTRATION NUMBER: NCT03711539.

Published
2021

15. Hinge point fibrosis in athletes is not associated with structural, functional or electrical consequences: a comparison between young and middle-aged elite endurance athletes

Author

De Bosscher, R, primary, Claeys, M, additional, Dausin, C, additional, Goetschalckx, K, additional, Bogaert, J, additional, Van De Heyning, C, additional, Ghekiere, O, additional, Herbots, L, additional, Claus, P, additional, Kalman, J, additional, Sanders, P, additional, Elliott, A, additional, Heidbuchel, H, additional, La Gerche, A, additional, and Claessen, G, additional

Published
2020
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16. 47CRT-D versus CRT-P: are we on the right track?

Author

Stassen, J, primary, Scherrenberg, M, additional, Vijgen, J, additional, Dilling, D, additional, Herbots, L, additional, Timmermans, PH J, additional, Schurmans, J, additional, Verwerft, J, additional, and Koopman, P, additional

Published
2020
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26. Poster Session: Right ventricular systolic function

Author

Altman, M., primary, Bergerot, C., additional, Thibault, H., additional, Aussoleil, A., additional, Skuldadt Davidsen, E., additional, Barthelet, M., additional, Derumeaux, G. A., additional, Grapsa, J., additional, Zimbarra Cabrita, I., additional, Afilalo, J., additional, Paschou, S., additional, Dawson, D., additional, Durighel, G., additional, O'regan, D., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Morenate Navio, M., additional, Mesa Rubio, M., additional, Ortega, M. D., additional, Ruiz Ortiz, M., additional, Castillo Bernal, F., additional, Del Pino, C. L., additional, Toledano, F., additional, Alvarez-Ossorio, M. P., additional, Ojeda Pineda, S., additional, Lezo Cruz-Conde, J. S. D., additional, Jasaityte, R., additional, Claus, P., additional, Teske, A., additional, Herbots, L., additional, Verheyden, B., additional, Rademakers, F., additional, D'hooge, J., additional, Tocchetti, C. G., additional, Coppola, C., additional, Rea, D., additional, Quintavalle, C., additional, Guarino, L., additional, Castaldo, N., additional, De Lorenzo, C., additional, Condorelli, G., additional, Arra, C., additional, Maurea, N., additional, Voilliot, D., additional, Huttin, O., additional, Camara, Y., additional, Djaballah, W., additional, Carillo, S., additional, Zinzius, P., additional, Sellal, J., additional, Angioi, M., additional, Juilliere, Y., additional, Selton-Suty, C., additional, Dobrowolski, P., additional, Klisiewicz, A., additional, Florczak, E., additional, Prejbisz, A., additional, Szwench, E., additional, Rybicka, J., additional, Januszewicz, A., additional, Hoffman, P., additional, Jurado Roman, A., additional, De Dios Perez, S., additional, De Nicolas, J. M. M., additional, Diaz Anton, B., additional, Rubio Alonso, B., additional, Martin Asenjo, R., additional, Mayordomo Gomez, S., additional, Villagraz Tecedor, L., additional, Blazquez, L., additional, De Meneses, R. T., additional, Bernard, A., additional, Hernandez, A. I., additional, Reynaud, A., additional, Lerclercq, C., additional, Daubert, J., additional, Donal, E., additional, Arjan Singh, R., additional, Sivarani, S., additional, Lim, S., additional, Azman, W., additional, Almeida, M., additional, Cardim, N., additional, Fonseca, V., additional, Carmelo, V., additional, Santos, S., additional, Santos, T., additional, Toste, J., additional, Kosmala, W., additional, Orda, A., additional, Karolko, B., additional, Mysiak, A., additional, Przewlocka-Kosmala, M., additional, Farsalinos, K., additional, Tsiapras, D., additional, Kyrzopoulos, S., additional, Avramidou, E., additional, Vassilopoulou, D., additional, Voudris, V., additional, Hayrapetyan, H., additional, Adamyan, K., additional, Montero Cabezas, J., additional, Granda Nistal, C., additional, Garcia Aranda, B., additional, Sanchez Sanchez, V., additional, Sestito, A., additional, Lamendola, P., additional, Di Franco, A., additional, Lauria, C., additional, Lanza, G., additional, Kukucka, M., additional, Unbehaun, A., additional, Buz, S., additional, Mladenow, A., additional, Kuppe, H., additional, Pasic, M., additional, Habazettl, H., additional, Gemma, D., additional, Montoro Lopez, N., additional, De Celix, M. G. R., additional, Lopez Fernandez, T., additional, De Torres Alba, F., additional, Del Valle, D. I., additional, Ramirez, U., additional, Mesa, J., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Eveborn, G. W., additional, Schirmer, H., additional, Lunde, P., additional, Heggelund, G., additional, Rasmussen, K., additional, Wang, Z., additional, Lasota, B., additional, Mizia-Stec, K., additional, Mizia, M., additional, Chmiel, A., additional, Adamczyk, T., additional, Chudek, J., additional, Gasior, Z., additional, Venkatesh, A., additional, Johnson, J., additional, Sahlen, A., additional, Brodin, L., additional, Winter, R., additional, Shahgaldi, K., additional, Manouras, A., additional, Valbuena, S., additional, Iniesta, A., additional, Lopez, T., additional, De Torres, F., additional, Salinas, P., additional, Garcia, S., additional, Moreno, M., additional, Lopez-Sendon, J., additional, Lebid, I., additional, Kobets, T., additional, Kuzmenko, T., additional, Katsanos, S., additional, Yiu, K., additional, Clavel, M., additional, Nina Ajmone, N., additional, Van Der Kley, F., additional, Rodes Cabau, J., additional, Schalij, M., additional, Bax, J., additional, Pibarot, P., additional, Delgado, V., additional, Fusini, L., additional, Tamborini, G., additional, Muratori, M., additional, Gripari, P., additional, Marsan, N., additional, Cefalu', C., additional, Ewe, S., additional, Maffessanti, F., additional, Pepi, M., additional, Hasselberg, N., additional, Haugaa, K., additional, Petri, H., additional, Berge, K., additional, Leren, T., additional, Bundgaard, H., additional, Edvardsen, T., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Coppola, M., additional, Rapisarda, O., additional, Cavallaro, C., additional, Vecchione, F., additional, D'onofrio, A., additional, Calabro', R., additional, Rimbas, R., additional, Mihaila, S., additional, Enescu, O., additional, Patrascu, N., additional, Dragoi, R., additional, Rimbas, M., additional, Pop, C., additional, Vinereanu, D., additional, Gustafsson, S., additional, Morner, S., additional, Gronlund, C., additional, Suhr, O., additional, Lindqvist, P., additional, Di Bella, G., additional, Zito, C., additional, Minutoli, F., additional, Madaffari, A., additional, Cusma Piccione, M., additional, Mazzeo, A., additional, Massimo, R., additional, Pasquale, M., additional, Vita, G., additional, Carerj, S., additional, Rangel, I., additional, Goncalves, A., additional, Sousa, C., additional, Correia, A., additional, Martins, E., additional, Silva-Cardoso, J., additional, Macedo, F., additional, Maciel, M., additional, Pfeiffer, B., additional, Rigopoulos, A., additional, Seggewiss, H., additional, Alvarez Fuente, M., additional, Sainz Costa, T., additional, Medrano, C., additional, Navarro, M., additional, Blazquez Gamero, D., additional, Ramos, J., additional, Mellado, M., additional, De Jose, M., additional, Munoz, M., additional, Maroto, E., additional, Gargani, L., additional, Gosciniak, P., additional, Pratali, L., additional, Agoston, G., additional, Bruni, C., additional, Guiducci, S., additional, Matucci Cerinic, M., additional, Varga, A., additional, Sicari, R., additional, Picano, E., additional, Zhao, C., additional, Mei, M., additional, Yeung, C., additional, Siu, C., additional, Tse, H., additional, Florescu, M., additional, Magda, L., additional, Mincu, R., additional, Daha, I., additional, Stanescu, C. M., additional, Chirila, L., additional, Baicus, C., additional, Vlase, A., additional, Dan, G., additional, Montoro Lopez, M., additional, Florez Gomez, R., additional, Alonso Ladreda, A., additional, Itziar Soto, C., additional, Rios Blanco, J., additional, Guzman Martinez, G., additional, Lichodziejewska, B., additional, Kurnicka, K., additional, Goliszek, S., additional, Kostrubiec, M., additional, Dzikowska-Diduch, O., additional, Ciurzynski, M., additional, Labyk, A., additional, Krupa, M., additional, Palczewski, P., additional, Pruszczyk, P., additional, De Sousa, C. C., additional, Vigario, A., additional, Pinho, T., additional, Silva Cardoso, J., additional, Park, S.-J., additional, Song, J.-E., additional, Lee, Y.-J., additional, Ha, M.-R., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Oh, J., additional, Van De Bruaene, A., additional, De Meester, P., additional, Buys, R., additional, Vanhees, L., additional, Delcroix, M., additional, Voigt, J., additional, Budts, W., additional, Blundo, A., additional, Buccheri, S., additional, Monte, I. P., additional, Leggio, S., additional, Tamburino, C., additional, Sotaquira, M., additional, Lang, R., additional, Caiani, E., additional, Floria, M., additional, De Roy, L., additional, Xhaet, O., additional, Blommaert, D., additional, Jamart, J., additional, Gerard, M., additional, Deceuninck, O., additional, Marchandise, B., additional, Seldrum, S., additional, Schroeder, E., additional, Unsworth, B., additional, Sohaib, S., additional, Kulwant-Kaur, K., additional, Malcolme-Lawes, L., additional, Kanagaratnam, P., additional, Malik, I., additional, Ren, B., additional, Mulder, H., additional, Haak, A., additional, Van Stralen, M., additional, Szili-Torok, T., additional, Pluim, J., additional, Geleijnse, M., additional, Bosch, J., additional, Baglini, R., additional, Amaducci, A., additional, D'ancona, G., additional, Van Den Oord, S., additional, Akkus, Z., additional, Ten Kate, G., additional, Renaud, G., additional, Sijbrands, E., additional, De Jong, N., additional, Van Der Lugt, A., additional, Van Der Steen, A., additional, Schinkel, A., additional, Bjallmark, A., additional, Larsson, M., additional, Grishenkov, D., additional, Brodin, L.-A., additional, Brismar, T., additional, Paradossi, G., additional, Sveen, K. A., additional, Nerdrum, T., additional, Hanssen, K., additional, Dahl-Jorgensen, K., additional, Steine, K., additional, Cimino, S., additional, Pedrizzetti, G., additional, Tonti, G., additional, Canali, E., additional, Petronilli, V., additional, Cicogna, F., additional, Arcari, L., additional, De Luca, L., additional, Iacoboni, C., additional, Agati, L., additional, Abdel Moneim, S. S., additional, Eifert Rain, S., additional, Bernier, M., additional, Bhat, G., additional, Hagen, M., additional, Bott-Kitslaar, D., additional, Castello, R., additional, Wilansky, S., additional, Pellikka, P., additional, Mulvagh, S., additional, Delithanasis, I., additional, Celutkiene, J., additional, Kenny, C., additional, Monaghan, M., additional, Park, W., additional, Hong, G., additional, Son, J., additional, Lee, S., additional, Kim, U., additional, Park, J., additional, Shin, D., additional, Kim, Y., additional, Toutouzas, K., additional, Drakopoulou, M., additional, Aggeli, C., additional, Felekos, I., additional, Nikolaou, C., additional, Synetos, A., additional, Stathogiannis, K., additional, Tsiamis, E., additional, Siores, E., additional, Stefanadis, C., additional, Plicht, B., additional, Kahlert, P., additional, Grave, T., additional, Buck, T., additional, Konorza, T., additional, Gursoy, M., additional, Gokdeniz, T., additional, Astarcioglu, M., additional, Bayram, Z., additional, Cakal, B., additional, Karakoyun, S., additional, Kalcik, M., additional, Acar, R., additional, Kahveci, G., additional, Ozkan, M., additional, Tsang, W., additional, Weinert, L., additional, Yurdakul, S., additional, Avci, B., additional, Sahin, S., additional, Dilekci, B., additional, Aytekin, S., additional, Arenga, F., additional, Hascoet, S., additional, Martin, R., additional, Dulac, Y., additional, Peyre, M., additional, Benzouid, C., additional, Hadeed, K., additional, Acar, P., additional, Zakarkaite, D., additional, Skorniakov, V., additional, Zvironaite, V., additional, Grabauskiene, V., additional, Burca, J., additional, Ciparyte, L., additional, Laucevicius, A., additional, Di Salvo, G., additional, Rea, A., additional, D'aiello, A., additional, Del Gaizo, F., additional, Pergola, V., additional, D'andrea, A., additional, Pacileo, G., additional, Calabro, R., additional, Russo, M., additional, Dedobbeleer, C., additional, Hadefi, A., additional, Naeije, R., additional, Unger, P., additional, Mornos, C., additional, Cozma, D., additional, Ionac, A., additional, Mornos, A., additional, Valcovici, M., additional, Pescariu, S., additional, Petrescu, L., additional, Hu, K., additional, Liu, D., additional, Niemann, M., additional, Herrmann, S., additional, Cikes, M., additional, Stoerk, S., additional, Knop, S., additional, Ertl, G., additional, Bijnens, B., additional, Weidemann, F., additional, De Knegt, M., additional, Biering-Sorensen, T., additional, Sogaard, P., additional, Sivertsen, J., additional, Jensen, J., additional, Mogelvang, R., additional, Lam, W., additional, Tang, M., additional, Chan, K., additional, Yang, Y., additional, Fang, F., additional, Sun, J., additional, Yu, C., additional, Lam, Y., additional, Panoulas, V., additional, Sulemane, S., additional, Bratsas, A., additional, Konstantinou, K., additional, Francone, M., additional, Schau, T., additional, Seifert, M., additional, Ridjab, D., additional, Schoep, M., additional, Gottwald, M., additional, Neuss, M., additional, Meyhoefer, J., additional, Zaenker, M., additional, Butter, C., additional, Tarr, A., additional, Stoebe, S., additional, Pfeiffer, D., additional, Hagendorff, A., additional, Maret, E., additional, Ahlander, B.-M., additional, Bjorklund, P.-G., additional, Engvall, J., additional, Staskiewicz, G., additional, Czekajska-Chehab, E., additional, Adamczyk, P., additional, Siek, E., additional, Przybylski, P., additional, Maciejewski, R., additional, Drop, A., additional, Jimenez Rubio, C., additional, Isasti Aizpurua, G., additional, Miralles Ibarra, J., additional, Al-Mallah, M., additional, Somg, T., additional, Alam, S., additional, Chattahi, J., additional, Zweig, B., additional, Dhanalakota, K., additional, Boedeker, S., additional, Ananthasubramaniam, K., additional, Park, C., additional, March, K., additional, Jones, S., additional, Mayet, J., additional, Tillin, T., additional, Chaturvedi, N., additional, Hughes, A., additional, Hamodraka, E., additional, Kallistratos, E., additional, Karamanou, A., additional, Tsoukas, T., additional, Mavropoulos, D., additional, Kouremenos, N., additional, Zaharopoulou, I., additional, Nikolaidis, N., additional, Kremastinos, D., additional, Manolis, A., additional, Loboz-Rudnicka, M., additional, Jaroch, J., additional, Bociaga, Z., additional, Kruszynska, E., additional, Ciecierzynska, B., additional, Dziuba, M., additional, Dudek, K., additional, Uchmanowicz, I., additional, Loboz-Grudzien, K., additional, Silva, D., additional, Magalhaes, A., additional, Jorge, C., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Silva Marques, J., additional, Portela, I., additional, Pascoa, C., additional, Nunes Diogo, A., additional, Brito, D., additional, Roosens, B., additional, Bala, G., additional, Droogmans, S., additional, Hostens, J., additional, Somja, J., additional, Delvenne, E., additional, Schiettecatte, J., additional, Lahoutte, T., additional, Van Camp, G., additional, and Cosyns, B., additional

Published
2012
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27. Poster Session 1: Thursday 8 December 2011, 08:30-12:30 * Location: Poster Area

Author

Vijayan, S., primary, Khanji, M., additional, Ionescu, A., additional, Vijayan, S., additional, Podoleanu, C., additional, Frigy, A., additional, Ugri, A., additional, Varga, A., additional, Podoleanu, D., additional, Incze, A., additional, Carasca, E., additional, Dobreanu, D., additional, Mjolstad, O., additional, Dalen, H., additional, Graven, T., additional, Kleinau, J., additional, Hagen, B., additional, Fu, H., additional, Liu, T., additional, Li, J., additional, Liu, C., additional, Zhou, C., additional, Li, G., additional, Bordese, R., additional, Capriolo, M., additional, Brero, D., additional, Salvetti, I., additional, Cannillo, M., additional, Antolini, M., additional, Grosso Marra, W., additional, Frea, S., additional, Morello, M., additional, Gaita, F., additional, Maffessanti, F., additional, Caiani, E., additional, Muraru, D., additional, Tuveri, F., additional, Dal Bianco, L., additional, Badano, L., additional, Majid, A., additional, Soesanto, A., additional, Ario Suryo Kuncoro, B., additional, Sukmawan, R., additional, Ganesja, M. H., additional, Benedek, T., additional, Chitu, M., additional, Beata, J., additional, Suciu, Z., additional, Kovacs, I., additional, Bucur, O., additional, Benedek, I., additional, Hrynkiewicz-Szymanska, A., additional, Szymanski, F., additional, Karpinski, G., additional, Filipiak, K., additional, Radunovic, Z., additional, Lande Wekre, L., additional, Steine, K., additional, Bech-Hanssen, O., additional, Rundqvist, B., additional, Lindgren, F., additional, Selimovic, N., additional, Jedrzychowska-Baraniak, J., additional, Jozwa, R., additional, Larysz, B., additional, Kasprzak, J., additional, Ripp, T., additional, Mordovin, V., additional, Ripp, E., additional, Ciobanu, A., additional, Dulgheru, R., additional, Dragoi, R., additional, Magda, S., additional, Florescu, M., additional, Mihaila, S., additional, Rimbas, R., additional, Cinteza, M., additional, Vinereanu, D., additional, Benavides-Vallve, C., additional, Pelacho, B., additional, Iglesias, O., additional, Castano, S., additional, Munoz-Barrutia, A., additional, Prosper, F., additional, Ortiz De Solorzano, C., additional, Manouras, A., additional, Sahlen, A., additional, Winter, R., additional, Vardas, P., additional, Brodin, L., additional, Sarvari, S. I., additional, Haugaa, K. H., additional, Zahid, W., additional, Bendz, B., additional, Aaberge, L., additional, Edvardsen, T., additional, Di Bella, G., additional, Pedri, S., additional, Donato, R., additional, Madaffari, A., additional, Zito, C., additional, Stapf, D., additional, Schreckenberg, M., additional, Carerj, S., additional, Yoshikawa, H., additional, Suzuki, M., additional, Kusunose, Y., additional, Hashimoto, G., additional, Otsuka, T., additional, Nakamura, M., additional, Sugi, K., additional, Grapsa, J., additional, Dawson, D., additional, Gin-Sing, W., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Smith, B., additional, Coulter, T., additional, Rendon, A., additional, Gorissen, W., additional, Shiran, A., additional, Asmer, I., additional, Adawi, S., additional, Ganaeem, M., additional, Shehadeh, J., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Maccherini, M., additional, Sani, G., additional, Galderisi, M., additional, Mondillo, S., additional, Kalimanovska-Ostric, D., additional, Nastasovic, T., additional, Jovanovic, I., additional, Milakovic, B., additional, Dostanic, M., additional, Stosic, M., additional, Sasic, I., additional, Sveen, K., additional, Nerdrum, T., additional, Hanssen, K., additional, Dahl-Jorgensen, K., additional, Holte, E., additional, Vegsundvaag, J., additional, Hole, T., additional, Hegbom, K., additional, Wiseth, R., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tritakis, V., additional, Papadakis, I., additional, Kadoglou, N., additional, Tzortzis, S., additional, Trivilou, P., additional, Koukoulis, C., additional, Paraskevaidis, I., additional, Anastasiou-Nana, M., additional, Smedsrud, M. K., additional, Sarvari, S., additional, Gjesdal, O., additional, Beraldo, M., additional, Solda', E., additional, Cucchini, U., additional, Peluso, D., additional, Tuveri, M., additional, Al Mamary, A., additional, Iliceto, S., additional, Dores, H., additional, Abecasis, J., additional, Carvalho, M., additional, Santos, M., additional, Andrade, M., additional, Ribeiras, R., additional, Reis, C., additional, Horta, E., additional, Gouveia, R., additional, Mendes, M., additional, Zaliaduonyte-Peksiene, D., additional, Mizariene, V., additional, Cesnaite, G., additional, Tamuleviciute, E., additional, Jurkevicius, R., additional, Vaskelyte, J., additional, Zaliunas, R., additional, Smarz, K., additional, Zaborska, B., additional, Jaxa-Chamiec, T., additional, Maciejewski, P., additional, Budaj, A., additional, Trifunovic, D., additional, Sobic-Saranovic, D., additional, Stankovic, S., additional, Ostojic, M., additional, Vujisic-Tesic, B., additional, Petrovic, M., additional, Nedeljkovic, I., additional, Banovic, M., additional, Tesic, M., additional, Petrovic, I., additional, Peovska, I., additional, Srbinovska, E., additional, Maksimovic, J., additional, Andova, V., additional, Arnaudova, F., additional, Hristova, E., additional, Otljanska, M., additional, Vavlukis, M., additional, Jovanova, S., additional, Tamborini, G., additional, Fusini, L., additional, Gripari, P., additional, Muratori, M., additional, Pontone, G., additional, Andreini, D., additional, Bertella, E., additional, Ghulam Ali, S., additional, Bartorelli, A., additional, Pepi, M., additional, Cusma-Piccione, M., additional, Salvia, J., additional, Antonini-Canterin, F., additional, Lentini, S., additional, Donato, D., additional, Miceli, M., additional, Oreto, G., additional, Sachner, R., additional, Rubinshtein, R., additional, Shnapp, M., additional, Gaspar, T., additional, Marchese, A., additional, Deste, W., additional, Sanfilippo, A., additional, Aruta, P., additional, Patane, M., additional, Millan, G., additional, Ussia, G., additional, Tamburino, C., additional, Kujacic, V., additional, Obradovic, S., additional, Crkvenac, Z., additional, Bernard, A., additional, Piquemal, M., additional, Muller, G., additional, Arbeille, P., additional, Charbonnier, B., additional, Broyd, C., additional, Davies, J., additional, Mikhail, G., additional, Mayet, J., additional, Francis, D., additional, Rosca, M., additional, Magne, J., additional, Szymanski, C., additional, Popescu, B., additional, Ginghina, C., additional, Pierard, L., additional, Lancellotti, P., additional, Gonzalez-Mansilla, A., additional, Solis, J., additional, Angulo, R., additional, Perez-David, E., additional, Madrid, G., additional, Garcia-Robles, J., additional, Yotti, R., additional, Prieto, R., additional, Bermejo, J., additional, Fernandez-Aviles, F., additional, Ishikawa, Y., additional, Ishida, T., additional, Osaki, T., additional, Matsuyama, M., additional, Yamashita, H., additional, Ozaki, S., additional, Stevanella, M., additional, Votta, E., additional, Veronesi, F., additional, Alamanni, F., additional, Redaelli, A., additional, Park, S. D., additional, Lee, J., additional, Shin, S., additional, Woo, S., additional, Kim, D., additional, Park, K., additional, Kwan, J., additional, Tsang, W., additional, Chandra, S., additional, Weinert, L., additional, Gayat, E., additional, Djelassi, M., additional, Balbach, T., additional, Mor-Avi, V., additional, Lang, R., additional, De Meester, P., additional, Van De Bruaene, A., additional, Delcroix, M., additional, Budts, W., additional, Abid, L., additional, Frikha, Z., additional, Makni, K., additional, Rekik, H., additional, Znazen, A., additional, Mourad, H., additional, Kammoun, S., additional, Sargento, L., additional, Satendra, M., additional, Sousa, C., additional, Lopes, S., additional, Longo, S., additional, Lousada, N., additional, Palma Reis, R., additional, Fouad, D., additional, Shams Eldeen, R., additional, Beladan, C., additional, Calin, A., additional, Voinea, F., additional, Enache, R., additional, Jurcut, R., additional, Coman, I., additional, Ghionea, M., additional, Djordjevic-Dikic, A., additional, Petrovic, O., additional, Boricic, M., additional, Giga, V., additional, Pisciella, L., additional, Lanzillo, C., additional, Minati, M., additional, Caselli, S., additional, Di Roma, M., additional, Fratini, S., additional, Romano, S., additional, Calo', L., additional, Lioy, E., additional, Penco, M., additional, Finocchiaro, G., additional, Pinamonti, B., additional, Merlo, M., additional, Barbati, G., additional, Sinagra, G., additional, Dilenarda, A., additional, Comenale Pinto, S., additional, Ancona, R., additional, Caso, P., additional, Cavallaro, C., additional, Vecchione, F., additional, D'onofrio, A., additional, Fero', M., additional, Calabro', R., additional, Gustafsson, S., additional, Ihse, E., additional, Henein, M., additional, Westermark, P., additional, Suhr, O., additional, Lindqvist, P., additional, Oliva Sandoval, M., additional, Gonzalez Carrillo, M., additional, Garcia Navarro, M., additional, Garcia-Molina Saez, E., additional, Sabater Molina, M., additional, Saura Espin, D., additional, Lacunza Ruiz, J., additional, Gimeno Blanes, J., additional, De La Morena Valenzuela, G., additional, Valdes Chavarri, M., additional, Prinz, C., additional, Faber, L., additional, Horstkotte, D., additional, Hoetz, H., additional, Voigt, J., additional, Gandara, F., additional, Correia, M., additional, Rosario, I., additional, Fonseca, C., additional, Arroja, I., additional, Aleixo, A., additional, Martins, A., additional, Radulescu, L., additional, Dan Radulescu, D., additional, Parv Andreea, P., additional, Duncea Caius, D., additional, Ciuleanu T, C., additional, Mitrea Paulina, M., additional, Cali Quaglia, F., additional, Ribezzo, M., additional, Boffini, M., additional, Rinaldi, M., additional, Maceira Gonzalez, A. M., additional, Cosin-Sales, J., additional, Dalli, E., additional, Diago, J., additional, Aguilar, J., additional, Ruvira, J., additional, Goncalves, S., additional, Gomes, A., additional, Pinto, F., additional, Tsai, W.-C., additional, Liu, Y.-W., additional, Shih, J.-Y., additional, Huang, Y.-Y., additional, Chen, J.-Y., additional, Tsai, L.-M., additional, Chen, J.-H., additional, Ribeiro, S., additional, Doroteia, D., additional, Santos, L., additional, David, C., additional, Vinhas De Sousa, G., additional, Almeida, A., additional, Iwase, M., additional, Itou, Y., additional, Yasukochi, S., additional, Shiino, K., additional, Inuzuka, H., additional, Sugimoto, K., additional, Ozaki, Y., additional, Gieszczyk-Strozik, K., additional, Sikora-Puz, A., additional, Mizia, M., additional, Lasota, B., additional, Chmiel, A., additional, Lis-Swiety, A., additional, Michna, J., additional, Brzezinska-Wcislo, L., additional, Mizia-Stec, K., additional, Gasior, Z., additional, Luijendijk, P., additional, De Bruin-Bon, H., additional, Zwiers, C., additional, Vriend, J., additional, Van Den Brink, R., additional, Mulder, B., additional, Bouma, B., additional, Brigido, S., additional, Gianfagna, P., additional, Proclemer, A., additional, Plicht, B., additional, Kahlert, P., additional, Kaelsch, H., additional, Buck, T., additional, Erbel, R., additional, Konorza, T., additional, Yoon, H., additional, Kim, K., additional, Ahn, Y., additional, Jeong, M., additional, Cho, J., additional, Park, J., additional, Kang, J., additional, Rha, W., additional, Jansen Klomp, W. W., additional, Brandon Bravo Bruinsma, G., additional, Van 'T Hof, A., additional, Spanjersberg, S., additional, Nierich, A., additional, Bombardini, T., additional, Gherardi, S., additional, Picano, E., additional, Ciarka, A., additional, Herbots, L., additional, Eroglu, E., additional, Van Cleemput, J., additional, Droogne, W., additional, Jasityte, R., additional, Meyns, B., additional, D'hooge, J., additional, Vanhaecke, J., additional, Al Barjas, M., additional, Iskreva, R., additional, Morris, R., additional, Davar, J., additional, Zhao, Y., additional, Holmgren, A., additional, Morner, S., additional, Stepanovic, J., additional, Beleslin, B., additional, Nedeljkovic, M., additional, Mazic, S., additional, Stojanov, V., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Eibel, S., additional, Hasheminejad, E., additional, Mukherjee, C., additional, Tschernich, H., additional, Ender, J., additional, Delithanasis, I., additional, Celutkiene, J., additional, Kenny, C., additional, Monaghan, M., additional, Van Den Oord, S., additional, Ten Kate, G., additional, Akkus, Z., additional, Renaud, G., additional, Sijbrands, E., additional, Ten Cate, F., additional, De Jong, N., additional, Bosch, J., additional, Van Der Steen, A., additional, Schinkel, A., additional, Lisowska, A., additional, Knapp, M., additional, Tycinska, A., additional, Sawicki, R., additional, Kralisz, P., additional, Sobkowicz, B., additional, Chang, S.-A., additional, Lee, S.-C., additional, Kim, E.-Y., additional, Hahm, S.-H., additional, Ahn, G.-T., additional, Sohn, M.-K., additional, Park, S.-J., additional, Choi, J.-O., additional, Park, S.-W., additional, Oh, J.-K., additional, Gursoy, M. O., additional, Gokdeniz, T., additional, Astarcioglu, M., additional, Bayram, Z., additional, Cakal, B., additional, Karakoyun, S., additional, Kalcik, M., additional, Kahveci, G., additional, Yildiz, M., additional, Ozkan, M., additional, Skidan, V., additional, Borowski, A., additional, Park, M., additional, Thomas, J., additional, Ranjbar, S., additional, Hassantash, S., additional, Karvandi, M., additional, Foroughi, M., additional, Davidsen, E. S., additional, Cramariuc, D., additional, Bleie, O., additional, Gerdts, E., additional, Matre, K., additional, Cusma' Piccione, M., additional, Bagnato, G., additional, Mohammed, M., additional, Piluso, S., additional, Oreto, L., additional, Bitter, T., additional, Carvalho, S., additional, Canada, M., additional, Santisteban Sanchez De Puerta, M., additional, Mesa Rubio, M. D., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Pena Pena, M. L., additional, Puentes Chiachio, M., additional, Suarez De Lezo Cruz-Conde, J., additional, Pan Alvarez-Ossorio, M., additional, Mazuelos Bellido, F., additional, Suarez De Lezo Herreros De Tejada, J., additional, Altekin, E., additional, Yanikoglu, A., additional, Karakas, S., additional, Oncel, C., additional, Akdemir, B., additional, Belgi Yildirim, A., additional, Cilli, A., additional, Yilmaz, H., additional, Lenartowska, L., additional, Furdal, M., additional, Knysz, B., additional, Konieczny, A., additional, Lewczuk, J., additional, Severino, S., additional, Cavallaro, M., additional, Coppola, M., additional, Motoki, H., additional, To, A., additional, Bhargava, M., additional, Wazni, O., additional, Marwick, T., additional, Klein, A., additional, Sinkovskaya, E., additional, Horton, S., additional, Abuhamad, A., additional, Mingo Santos, S., additional, Monivas Palomero, V., additional, Beltran Correas, B., additional, Mitroi, C., additional, Gutierrez Landaluce, C., additional, Garcia Lunar, I., additional, Gonzalez Mirelis, J., additional, Cavero, M., additional, Segovia Cubero, J., additional, Alonso Pulpon, L., additional, Gurel, E., additional, Karaahmet, T., additional, Tigen, K., additional, Kirma, C., additional, Dundar, C., additional, Pala, S., additional, Isiklar, I., additional, Cevik, C., additional, Kilicgedik, A., additional, Basaran, Y., additional, Brambatti, M., additional, Romandini, A., additional, Barbarossa, A., additional, Molini, S., additional, Urbinati, A., additional, Giovagnoli, A., additional, Cipolletta, L., additional, Capucci, A., additional, Park, S., additional, Choi, E., additional, Ahn, C., additional, Hong, S., additional, Kim, M., additional, Lim, D., additional, Shim, W., additional, Xie, J., additional, Fang, F., additional, Zhang, Q., additional, Chan, J., additional, Yip, G., additional, Sanderson, J., additional, Lam, Y., additional, Yan, B., additional, Yu, C., additional, Jorge Perez, P., additional, De La Rosa Hernandez, A., additional, Hernandez Garcia, C., additional, Duque Garcia, A., additional, Barragan Acea, A., additional, Arroyo Ucar, E., additional, Jimenez Rivera, J., additional, Lacalzada Almeida, J., additional, Laynez Cerdena, I., additional, Carminati, C., additional, Capoulade, R., additional, Larose, E., additional, Clavel, M., additional, Dumesnil, J., additional, Arsenault, M., additional, Bedard, E., additional, Mathieu, P., additional, Pibarot, P., additional, Gargani, L., additional, Baldi, G., additional, Forfori, F., additional, Caramella, D., additional, D'errico, L., additional, Abramo, A., additional, Sicari, R., additional, Giunta, F., additional, Lee, W.-N., additional, Larrat, B., additional, Messas, E., additional, Pernot, M., additional, Tanter, M., additional, Velagic, V., additional, Cikes, M., additional, Matasic, R., additional, Skorak, I., additional, Samardzic, J., additional, Puljevic, D., additional, Lovric Bencic, M., additional, Biocina, B., additional, Milicic, D., additional, Roosens, B., additional, Bala, G., additional, Droogmans, S., additional, Hostens, J., additional, Somja, J., additional, Delvenne, E., additional, Schiettecatte, J., additional, Lahoutte, T., additional, Van Camp, G., additional, Cosyns, B., additional, Ghosh, A., additional, Hardy, R., additional, Chaturvedi, N., additional, Deanfield, J., additional, Pellerin, D., additional, Kuh, D., additional, Hughes, A., additional, Malmgren, A., additional, Dencker, M., additional, Stagmo, M., additional, Gudmundsson, P., additional, Seo, Y., additional, Ishizu, T., additional, Aonuma, K., additional, Schuuring, M. J., additional, Vis, J., additional, Van Dijk, A., additional, Van Melle, J., additional, Pieper, P., additional, Vliegen, H., additional, Sieswerda, G., additional, Foukarakis, E., additional, Pitarokilis, A., additional, Kafarakis, P., additional, Kiritsi, A., additional, Klironomos, E., additional, Manousakis, A., additional, Fragiadaki, X., additional, Papadakis, E., additional, and Dermitzakis, A., additional

Published
2011
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30. Improved regional function after autologous bone marrow-derived stem cell transfer in patients with acute myocardial infarction: a randomized, double-blind strain rate imaging study

Author

Herbots, L., primary, D'hooge, J., additional, Eroglu, E., additional, Thijs, D., additional, Ganame, J., additional, Claus, P., additional, Dubois, C., additional, Theunissen, K., additional, Bogaert, J., additional, Dens, J., additional, Kalantzi, M., additional, Dymarkowski, S., additional, Bijnens, B., additional, Belmans, A., additional, Boogaerts, M., additional, Sutherland, G., additional, Van de Werf, F., additional, Rademakers, F., additional, and Janssens, S., additional

Published
2008
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43. Systolic and diastolic left ventricular dysfunction: from risk factors to overt heart failure.

Author

Kuznetsova T, Herbots L, Jin Y, Stolarz-Skrzypek K, Staessen JA, Kuznetsova, Tatiana, Herbots, Lieven, Jin, Yu, Stolarz-Skrzypek, Katarzyna, and Staessen, Jan A

Abstract

Because life expectancy and the prevalence of risk factors such as hypertension, obesity and diabetes are rising globally, heart failure (HF) is growing into a major health problem. Impairment of left ventricular (LV) diastolic function as well as systolic function appear very early in the course of heart disease. Recent HF guidelines, therefore, place special emphasis on the detection of subclinical LV dysfunction and the timely identification of risk factors for HF. Conventional echocardiography combined with new imaging techniques such as tissue Doppler and tissue tracking are sensitive tools to detect early subclinical deterioration of LV function. Community-based studies revealed a higher prevalence of LV systolic and diastolic dysfunction using the new echocardiographic imaging techniques. Future prospective studies will clarify the hitherto unknown prognosis associated with early symptom-free LV dysfunction. [ABSTRACT FROM AUTHOR]

Published
2010
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44. Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients.

Author

Mullens W, Bartunek J, Wilson Tang WH, Delrue L, Herbots L, Willems R, De Bruyne B, Goethals M, Verstreken S, Vanderheyden M, Mullens, Wilfried, Bartunek, Jozef, Tang, W H Wilson, Delrue, Leen, Herbots, Lieven, Willems, Rik, De Bruyne, Bernard, Goethals, Marc, Verstreken, Sofie, and Vanderheyden, Marc

Abstract

Background: Heart failure is associated with a reduction in left ventricular (LV) contractility as evidenced by a blunted force-frequency response (FFR) and downregulation of contractility regulating genes.Objective: This study sought to investigate whether cardiac resynchronization therapy (CRT) is capable of reversing the blunted FFR and the downregulation of contractility regulating genes.Methods: Twenty heart failure patients underwent echocardiographic examination during incremental AAI and DDD-CRT pacing at 70, 90, and 110 beats/min, immediately after and 4 months after CRT implantation. The FFR was determined from the ratio of the LV systolic pressure/end systolic volume index at given heart rate. In a subgroup of 6 patients with idiopathic dilated cardiomyopathy, serial LV dP/dtmax was invasively measured during both pacing modes and serial LV endomyocardial biopsies were taken to measure sarcoplasmatic reticulum calcium ATPase 2alpha (SERCA2alpha), phospholamban (PLN), sarcolemmal sodium calcium exchanger (NCX), beta1-adrenoreceptor (beta1-AR), and apelin (APL) gene expression using reverse-transcriptase polymerase chain reaction.Results: Acutely, DDD-CRT pacing was associated with a decrease in dyssynchrony (P <.01) and increase in diastolic filling time (P <.01) at all heart rates paralleled by an upward shift of the FFR (P <.01) without force-frequency amplification. A greater upward shift of the FFR was noticed during DDD-CRT as compared with AAI (P <.01) after 4 months. In addition, CRT was associated with a significant force-frequency amplification at follow-up as evidenced from the steeper slope of the FFR relationship (P = .039). This was associated with a significant upregulation of SERCA2alpha P = .01), PLN (P = .01), their ratio (P = .01), ratio of SERCA/NCX (P = .02), beta1-AR (P = .03), and APL (P = .01) mRNA levels.Conclusion: CRT is associated with an acute upward shift in the FFR without force-frequency amplification related to restored synchronicity and increased filling time of the LV. Only chronic CRT is associated with force-frequency amplification in parallel to upregulation of contractility regulating genes. [ABSTRACT FROM AUTHOR]

Published
2008
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45. The Potential Value of Ultrasonic Deformation Measurement in Differentiating Regional Ischaemic Substrates During Dobutamine Stress Echocardiography.

Author

Kowalski, M, Herbots, L, Weidemann, F, Dommke, C, Mertens, P, Mortelmans, L, Bijnens, B, Herregods, M.-C, and Sutherland, G.R

Subjects
DOBUTAMINE, ECHOCARDIOGRAPHY, CORONARY disease, CORONARY angiography, POSITRON emission tomography
Abstract

The differentiation between differing regional ischaemic substrates is crucial for decision-making in patients with coronary artery disease. This study demonstrates that quantification of dobutamine stress echocardiography using ultrasonic strain measurement has the potential to identify three differing regional ischaemic substrates (ischaemic, stunned and scarred) in the same patient. The data were validated by traditional analysis of dobutamine stress echo, coronary angiography and correlative quantitative positron emission tomography information. Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved. [ABSTRACT FROM AUTHOR]

Published
2003
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46. The Feasibility of Ultrasonic Regional Strain and Strain Rate Imaging in Quantifying Dobutamine Stress Echocardiography.

Author

Kowalski, M., Herregods, M.-C., Herbots, L., Weidemann, F., Simmons, L., Strotmann, J., Dommke, C., D'hooge, J., Claus, P., Bijnens, B., Hatle, L., and Sutherland

Subjects
FEASIBILITY studies, CARDIOMYOPATHIES, STRAIN rate, DOBUTAMINE, STRESS echocardiography, HEART beat, MEDICAL artifacts, ISCHEMIA
Abstract

Background: Ultrasonic strain rate and strain can characterize regional one-dimensional myocardial deformation at rest. In theory, these deformation indices could be used to quantify normal or abnormal regional function during a dobutamine stress echo test.Aims: The aims of our pilot study were threefold: (1) to determine the percentage of segments in which interpretable strain rate/strain data could be obtained during routine dobutamine stress echo, (2) to establish whether either the increase in heart rate or artefacts induced by respiration during dobutamine stress echo would influence analysis by degrading the data and (3) to determine the optimal frame rate vs image sector angle settings for data acquisition. Furthermore, although the detection of ischaemia was not to be addressed specifically in this study, we would describe the findings on the potential clinical role of regional deformation vs velocity imaging in detecting ischaemia-induced changes.Methods: A standard dobutamine stress echo protocol was performed in 20 consecutive patients with a history of chest pain (16 with angiographic coronary artery disease and four with normal coronary angiograms). DMI velocities were acquired at baseline, low dose, peak dose, and recovery. To evaluate radial function (basal segment of the left ventricle posterior wall segment), parasternal LAX, SAX views were used. For long axis function data were acquired (4-CH, 2-CH views) from the septum; lateral, inferior and anterior left ventricle walls. Data was acquired using both 15° (>150 frames per second (fps) and 45° (115 fps) sector angles. During post-processing each wall was divided into three segments: basal, mid and apical. Strain rate/strain values were averaged over three consecutive heart cycles.Results: Data was obtained from 1936 segments, of which only 54 had to be excluded from subsequent analysis (2.8%) because of suboptimal quality. An increase in heart rates (up to 150/min) was not associated with a significant reduction in the number of interpretable segments. There was a significant correlation between maximal systolic strain rate/strain values obtained at narrow and at wide sector angles (e.g. a correlation for the septal segments: r=0.73,P <0.001 for strain rate, and r=0.71; P<0.001 for strain). The correlation for the timing of events obtained from narrow and wide sector angles was weaker. This would indicate that there was the insufficient temporal resolution for the latter acquisition method. Normal and abnormal regional strain rate/strain responses to an incremental dobutamine infusion were defined. In normal segments, maximal systolic strain rate values increased continuously from baseline, reaching the highest values at the peak dose of dobutamine. The segmental strain response was different. For strain, there was an initial slight increase at low dose of dobutamine (5, 10 μg/kg/min), but no further increase with increasing dose. A pattern representing an ischaemic response was identified and described.Conclusions: The feasibility study would suggest that with appropriate data collection and post-processing methodologies, strain rate/strain imaging can be applied to the quantification of dobutamine stress echo. However, appropriate post-processing algorithms must be introduced to reduce data analysis time in order to make this a practical clinical technique. Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved. [ABSTRACT FROM AUTHOR]

Published
2003
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47. Characterizing Abnormal Regional Longitudinal Function in Arrhythmogenic Right Ventricular Dysplasia. The Potential Clinical Role of Ultrasonic Myocardial Deformation Imaging.

Author

Herbots, L., Kowalski, M., Vanhaecke, J., Hatle, L., and Sutherland, G.R.

Subjects
DYSPLASIA, RIGHT heart ventricle, HEART ventricle abnormalities, HEART failure, MAGNETIC resonance imaging, HEART dilatation, RIGHT heart atrium
Abstract

The article presents a case study of a 50-year-old man who was dignosed of arrhythmogenic right ventricular dysplasia. The man has a history of progressive heart failure and has Klinefelters Syndrome. The initial magnetic resonance imaging (MRI) scan showed a mild dilatation on the right ventricle and right atrium of the man with marked thinning of the middle and basal free wall of the right ventricle. The article discusses arrhythmogenic right ventricular dysplasia and MRI.

Published
2003
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50. 403 Echocardiographic resolution of cardiac amyloidosis after high dose — Melphalan and autologous blood stem cell transplantation

Author

Mullens, W., Herbots, L., Louw, V., Herregods, M.C., and Vahaecke, J.

Subjects
*CARDIAC amyloidosis, *STEM cell transplantation
Abstract

An abstract of the study "Echocardiographic resolution of cardiac amyloidosis after high dose - Melphalan and autologous blood stem cell transplantation," by W. Mullens and colleagues is presented.

Published
2004
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