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24. Targeted Design of Dynamic and Mechanical Bonds Towards Functional, Responsive Polymeric Networks

Author

Herbert, Katie Marie

Subjects
Chemistry, Materials Science
Abstract

The implementation of dynamic chemistries into polymeric materials has led the way towards the development of functional materials that express a multitude of targeted responses. The use of dynamic covalent chemistries as well as mechanical bonds have shown great potential in the rapidly growing field of stimuli-responsive polymer materials. This dissertation will focus on moving towards tunable, functional polymer networks based on two different binding motifs: the dynamic thia-Michael addition and the doubly-threaded [3]-rotaxane. Although there is a great deal of dynamic covalent chemistries currently in use for functional materials, the thia-Michael addition reaction has only recently begun to be explored as a reversible bond in polymeric materials. Of particular interest is the benzalcyanoacetate Michael acceptor that undergoes dynamic exchange with thiols under ambient conditions. By mindfully adjusting the chemical composition of the Michael acceptor, it is possible to tune the chemical equilibrium of the thia-Michael reaction and hierarchically program thermomechanical and morphological properties of thia-Michael networks. The dynamic, phase separated films exhibit a range of functionalities including shape memory response and adhesive applications. Similarly, the development of an interlocked binding structure for crosslinked materials will lead to a host of unexplored responsive properties. Utilizing a metal-templated approach to target an interlocked [3]-rotaxane, progress towards the development of slide-ring gel materials will be described.

Published
2019
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29. Former CEO Girds for Fight With Vineyard

Author

Kuehner-Herbert, Katie

Subjects
Vineyard National Bancorp. -- Investor relations, Vineyard National Bancorp. -- Officials and employees, Banking industry -- Investor relations, Banking industry -- Officials and employees, Banking industry, Banking, finance and accounting industries, Business, Economics
Abstract

A proxy fight is brewing at Vineyard National Bancorp - and the antagonist is the Corona, Calif., company's former chief executive officer. Norman Morales resigned as the $2.5 billion-asset Vineyard's [...]

Published
2008

31. Gripe Site Helping Thrift Make a Name for Itself.

Author

Kuehner-Herbert, Katie

Subjects
ADVERTISING campaigns, INTERNET marketing, ADVERTISING media planning, WEBSITES
Abstract

The article focuses on an advertising campaign by HomeStreet Bank, a thrift banking company, in which customers were invited to post complaints about bank experiences at an anonymous web site, www.mybankdoesntgetit.com. After wide popularity in two weeks of operation, the company posted a link to a new bank web site, homestreetgetsit.com. The director of marketing for the company, Richard Bendix, discusses the success of the campaign.

Published
2006

32. Banking On Immigration.

Author

Kuehner-Herbert, Katie

Subjects
COMMUNITY banks, CENTRAL banking industry, IMMIGRANTS, SPANISH language
Abstract

Discusses the ability of U.S. community banks to endure the intention of big banks to encroach on the immigrant market. Launch of a Chinese- and English-language website by the East West Bank in San Francisco; Expertise of community banks in international trade finance; Experience of smaller banks in using its resources to attract non-English speaking clients; Use of Spanish speaking staff members.

Published
2003

33. Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment.

Author

Skillin NP, Kirkpatrick BE, Herbert KM, Nelson BR, Hach GK, Günay KA, Khan RM, DelRio FW, White TJ, and Anseth KS

Subjects
Anisotropy, Animals, Mice, Cell Line, Cell Differentiation, Muscle Contraction physiology, Myoblasts cytology, Muscle Fibers, Skeletal physiology, Extracellular Matrix
Abstract

The ability of cells to organize into tissues with proper structure and function requires the effective coordination of proliferation, migration, polarization, and differentiation across length scales. Skeletal muscle is innately anisotropic; however, few biomaterials can emulate mechanical anisotropy to determine its influence on tissue patterning without introducing confounding topography. Here, we demonstrate that substrate stiffness anisotropy coordinates contractility-driven collective cellular dynamics resulting in C2C12 myotube alignment over millimeter-scale distances. When cultured on mechanically anisotropic liquid crystalline polymer networks (LCNs) lacking topography, C2C12 myoblasts collectively polarize in the stiffest direction. Cellular coordination is amplified through reciprocal cell-ECM dynamics that emerge during fusion, driving global myotube-ECM ordering. Conversely, myotube alignment was restricted to small local domains with no directional preference on mechanically isotropic LCNs of the same chemical formulation. These findings provide valuable insights for designing biomaterials that mimic anisotropic microenvironments and underscore the importance of stiffness anisotropy in orchestrating tissue morphogenesis.

Published
2024
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34. Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment.

Author

Skillin NP, Kirkpatrick BE, Herbert KM, Nelson BR, Hach GK, Günay KA, Khan RM, DelRio FW, White TJ, and Anseth KS

Abstract

In skeletal muscle tissue, injury-related changes in stiffness activate muscle stem cells through mechanosensitive signaling pathways. Functional muscle tissue regeneration also requires the effective coordination of myoblast proliferation, migration, polarization, differentiation, and fusion across multiple length scales. Here, we demonstrate that substrate stiffness anisotropy coordinates contractility-driven collective cellular dynamics resulting in C2C12 myotube alignment over millimeter-scale distances. When cultured on mechanically anisotropic liquid crystalline polymer networks (LCNs) lacking topographic features that could confer contact guidance, C2C12 myoblasts collectively polarize in the stiffest direction of the substrate. Cellular coordination is amplified through reciprocal cell-ECM dynamics that emerge during fusion, driving global myotube-ECM ordering. Conversely, myotube alignment was restricted to small local domains with no directional preference on mechanically isotropic LCNs of same chemical formulation. These findings reveal a role for stiffness anisotropy in coordinating emergent collective cellular dynamics, with implications for understanding skeletal muscle tissue development and regeneration., Competing Interests: Declaration of Interests The authors declare no competing interests.

Published
2023
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