Search

Modern weapons cause severe damage, accompanied by high rates of complications and mortality. The investigation of such kinds of weapons is in high demand considering the ongoing active phase war against Ukraine since February 2022. In order to understand the pathological processes that occur in and outside the gunshot wound, we conducted an experimental study using mathematical simulation. The results presented in the article will help to choose the appropriate surgical management and improve the results of treatment. The aim of this study was to investigate and evaluate the damaging effect of a 5.45 mm 7N6M bullet and a 5.45 mm V-max expansive bullet using numerical modeling of wound canals in ballistic plasticine. The Ansys Explicit Dynamics engineering complex was used to simulate the dynamics of the bullet’s motion. The basic equations, solved by the explicit dynamic analysis, express the conservation of mass, momentum, and energy in Lagrange coordinates. Together with the material model and the set of initial and boundary conditions, they determine the complete solution to the problem. Taking into account that the initial velocity of the bullet is 1185 m/s at a mass of 3.9 g, we obtain energy 2740 J. All this energy acts at the area of the wound canal with a depth of 150 mm. Injury with a conventional 7N6M bullet is characterized by the fact that it passes through the block and loses only part of the kinetic energy. The simulation results showed that the velocity of the bullet at the outlet is 220 m/s. Taking into account the initial velocity of the bullet 918 m/s with a mass of 3.4 g, we obtain the kinetic energy acting on the walls of the wound canal with a depth of 200 mm of about 830 J. Mathematic analyses showed that the expansive bullet has a soft core that deforms and transfers all the kinetic energy to the tissues immediately after penetration into the tissues. The loss of kinetic energy of the bullet (ΔE, J) is defined as the difference between the kinetic energy at the time of injury (Ec, J) and the residual energy of the bullet when leaving the material (Er, J). Numerical modeling of wound ballistics in biological tissue simulators allows us to determine with high accuracy the features of wound canal formation and tissue response to damage of bullets having different kinetic energy, which contributes to the choice of adequate surgical management during surgery for gunshot wounds. [ABSTRACT FROM AUTHOR]

The article provides argumentation regarding the the essence, composition and structure of the ecosystem of human resources of organizations in the contour of human-centeredness. The factors of paradigm changes in the management of human resources of organizations in the third decade of the XXI century are disclosed. Factual data of asymmetries and contradictions in the current state of the social and labor sphere in the global dimension, that become a threat to national security, are presented. The main drivers of the global economy have been allocated as evidence of the unattainability of social quality standards. The relevance of the ecosystem of human resources of organizations as the main focus of economic activity is substantiated. The understanding of the theoretical construct is revealed and the fundamental foundations of the conceptology of the ecosystem of human resources in the context of human-centeredness are outlined. Within the framework of the genesis, the components and semantic characteristics of the concept of «ecosystem» are highlighted. A comparative parallel is drawn between the ecosystem of human resources of organizations and traditional HR management. The innovations in social and labor relations, also in the in social and labor interaction of economic agents in the ecosystem are defined. The mental model of the ecosystem of human resources as one of the local components of the socioeconomic system and the «product» of economic convergence is disclosed. The actualization of new, non-standard, hybrid forms of relationships and interactions between socioeconomic agents is underlined. Emphasis is placed on the post-industrial type of social and labor convergence. A comprehensive map has been proposed, which clearly reflects the authors? own vision of the structure and component saturation of the ecosystem of human resources of organizations. The primacy and dominance of social policy in a human-oriented society are substantiated. The complex dimension of the human-centeredness model is emphasized and the components of this model are allocated. The authors? assessments of the future of man in the era of digitalization against the background of pessimistic forecasts of the gurus of modern economic thought are presented. The authors express the conviction of the need to establish a new worldview and human-oriented thinking for the sake of a balanced and agnostic perspective of sustainable socioeconomic, including socio-labor, development.

The aim of the article is to develop a science-based practical scenario and argue the content of the main components of grading as a managerial innovation in designing basic wages in high-tech enterprises. The need to improve managerial approaches to forming an effective wage system as a determinant of attracting, securing and using human resources of high-tech enterprises is substantiated. The requirements to the development of remuneration systems in a competitive environment are formulated. The argument for the widespread dissemination of the traditional tariff model of remuneration, which has undergone a deep crisis in the market economy, is given. The need to modernize standard wage systems is noted. The quintessence of the article is the implementation of the theoretical and applied aspects of grading as an innovative approach to remuneration in the management practice of high-tech enterprises with consideration for peculiarities of their human resources and labor processes. It is emphasized that the competencies of the personnel of high-tech enterprises form the prerequisites for ensuring their competitive development. Attention is focused on the fact that labor remuneration, as a component of the complex motivational mechanism of high-tech enterprises, combines management tools that stimulate the manufacturing of high-tech products and high-tech services. A set of factors characterizing the significance of positions in high-tech enterprises is formed, which ensures their correlation with the size of wages. Alternative point factor matrices for assessing the significance of works / positions for high-tech enterprises with the same and different number of levels are proposed. A matrix describing the factors for assessing the significance of works / positions is developed. In the context of the effectiveness of wage systems, the feasibility of combining grading and performance management using key performance indicators is noted. The possibility for providing the differentiation and strengthening of individualization of wages is substantiated.

The article is aimed at distinguishing between the concepts of «freelance», «remote employment», «work from home» with highlighting of differences affecting the organizational-legal format and the economic aspects of social and labor relations between the parties to the agreements on work in remote mode. The prerequisites for the emergence of the non-standard forms of employment in the conditions of establishing the post economy and the electronic-network society have been determined. The data of sociological researches on the current condition and prospects of prevalence of remote employment in Ukraine have been provided. The types and forms of remote employment have been generalized according to different classifications. Using a number of criteria, the article discloses characteristic features of such atypical forms of employment as freelance, distance employment, and work from home. The disadvantages of the atypical forms of employment have been allocated and their advantages have been generalized. An analysis of the current normative-legal regulation has been carried out and the substantiation of organizational and economic foundations of freelancing, remote employment, work from home in Ukraine has been provided.

The aim of the article is the theoretical and applied substantiation of competitiveness of workplaces as a defining feature and component for provision of decent work. The author’s interpretation of the concept “competitiveness of workplaces” and signs of its manifestation in different aspects of social and labor relations are given. Suggestions for improving the methodological structure of the certification of workplaces in the context of determining the components of their competitiveness are outlined. The necessity of implementing a number of measures to create new high-tech workplaces and modernize the existing ones with the aim of bringing their level to the competitive one is justified. The results of analyzing individual indicators of competitiveness of workplaces in the economy of Ukraine for 2006-2015 are presented. It is proved that under conditions of the entry of Ukraine into the European space, the dominant factor in increasing the competitiveness of workplaces is the modernization of the existing ones and bringing them to the level of high-tech and high-performance ones. It is noted that the theoretical and methodological basis for assessing the level of competitiveness of workplaces and determining the directions for its improvement is formed by the concept of decent work and the indicators of decent work deficit that are singled out on its basis.

Target class-focused drug discovery has a strong track record in pharmaceutical research, yet public domain data indicate that many members of protein families remain unliganded. Here we present a systematic approach to scale up the discovery and characterization of small molecule ligands for the WD40 repeat (WDR) protein family. We developed a comprehensive suite of protocols for protein production, crystallography, and biophysical, biochemical, and cellular assays. A pilot hit-finding campaign using DNA-encoded chemical library selection followed by machine learning (DEL-ML) to predict ligands from virtual libraries yielded first-in-class, drug-like ligands for 7 of the 16 WDR domains screened, thus demonstrating the broader ligandability of WDRs. This study establishes a template for evaluation of protein family wide ligandability and provides an extensive resource of WDR protein biochemical and chemical tools, knowledge, and protocols to discover potential therapeutics for this highly disease-relevant, but underexplored target class.