15 results on '"Hepkaya E"'
Search Results
2. Home mechanical ventilation in children: The experience of pediatric pulmonology divisions in Istanbul
- Author
-
Yanaz, M, primary, Unal, F, additional, Hepkaya, E, additional, Yazan, H, additional, Can Oksay, S, additional, Kostereli, E, additional, Yilmaz Yegit, C, additional, Kilic Baskan, A, additional, Onay, Z R, additional, Gulieva, A, additional, Soyyigit, A, additional, Kalyoncu, M, additional, Kucuk, H B, additional, Ayhan, Y, additional, Ergenekon, A P, additional, Atag, E, additional, Uzuner, S, additional, Bas Ikizoglu, N, additional, Ayzit Kilinc, A, additional, Ay, P, additional, Erdem Eralp, E, additional, Gokdemir, Y, additional, Oktem, S, additional, Cakir, E, additional, Girit, S, additional, Uyan, Z S, additional, Cokugras, H, additional, Ersu, R, additional, Karadag, B, additional, and Karakoc, F, additional
- Published
- 2022
- Full Text
- View/download PDF
3. P060 Factors associated with pulmonary functions of cystic fibrosis (CF) patients in the National Cystic Fibrosis Patient Registry: a retrospective cohort study
- Author
-
Çobanogĝlu, N., primary, Emiralioglu, N., additional, Çakır, B., additional, Sertçelik, A., additional, Yalçın, E., additional, Kiper, N., additional, Şen, V., additional, Ufuk Altıntasş, D., additional, Çokuĝraş, H., additional, Sakallı, A.A. Kılınç, additional, Başkan, A.Kılıç, additional, Hepkaya, E., additional, Yazan, H., additional, Türel, Ö., additional, Yılmaz, A.İ., additional, Ünal, G., additional, Caĝlar, T., additional, Damadoglu, E., additional, Irmak, İ., additional, Demir, E., additional, Öztürk, G., additional, Bingöl, A., additional, Başaran, E., additional, Sapan, N., additional, Aslan, A.T., additional, Asfuroğlu, P., additional, Harmancı, K., additional, Köse, M., additional, Hangül, M., additional, Özdemir, A., additional, Tuĝcu, G., additional, Polat, S. Eryılmaz, additional, Özcan, G., additional, Gayretli, Z.G., additional, Keskin, Ö., additional, Bilgiç, S., additional, Yüksel, H., additional, Özdoĝan, Ş., additional, Topal, E., additional, Çaltepe, G., additional, Can, D., additional, Ekren, P. Korkmaz, additional, Kılıç, M., additional, Süleyman, A., additional, Eyüboĝlu, T. Şişmanlar, additional, Cinel, G., additional, Pekcan, S., additional, Çakır, E., additional, Özcelik, U., additional, and Doĝru, D., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Immunomodulator effect of topical zinc oxide application in tuberculin skin test
- Author
-
Ömer Ceran, Zehra Esra Önal, Çağatay Nuhoğlu, Tamay Gürbüz, Hepkaya E, Atasayan, and Narin Akici
- Subjects
medicine.medical_specialty ,Tuberculosis ,chemistry.chemical_element ,Tuberculin ,lcsh:Medicine ,Zinc ,Placebo ,Topical zinc oxide ,Forearm ,Medicine ,Tuberculin Skin Test ,lcsh:R5-920 ,Test site ,business.industry ,lcsh:R ,Skin test ,tuberculin skin test ,zinc ,Purified Protein Derivative ,medicine.disease ,bacterial infections and mycoses ,Dermatology ,medicine.anatomical_structure ,chemistry ,Immunology ,Original Article ,business ,lcsh:Medicine (General) ,General Economics, Econometrics and Finance - Abstract
WOS: 000433094100008 PubMed ID: 29607430 OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis.
- Published
- 2018
5. Numerical Estimation Of Swirl And Tumble Numbers In Ricardo Research Engine Cylinder For Variable Valve Lifts
- Author
-
KARAASLAN, S., HEPKAYA, E., YÜCEL, N., and USLU, S.
- Subjects
Ricardo Engine,Swirl and Tumble Number,CFD Simulation - Abstract
The turbulence is one of the most important parameters for internal combustion engines. Enough turbulence formations will result in a better mixing process of air and fuel and it will also enhance flame development. The desired turbulent character can be obtained with a well designed intake port. In this study, swirl and tumble motion investigations were performed for Ricardo E6 Research Engine. The CAD model of the engine cylinder with only intake port and intake valve was prepared and imported to STAR- CCM+ v6.04 software. The energy solver was frozen and segregated solver was used during the solutions. The turbulence model selection was a key point for such an analysis. So, three turbulence models (Realizable k-s, k-ro-SST and LES) were compared. The k-s model was found more suitable and stable for these cases. In our investigation, there were two case studies. One of them was effect of valve lift change on swirl and tumble number while the engine was operated constant speed. The second one was effect of engine speed on swirl and tumble number for a unique valve lift. As it is expected for a gasoline engine, the tumble numbers remain higher than swirl numbers. The valve lift change results showed that while increasing of valve lift increased the swirl numbers but decreased the tumble numbers. This inversely proportional result arises from the momentum transform between the angular and axial motions. Anyway, both dimensionless numbers were increased with the engine speed increasing and it was seen that the engine speed is the most effective parameter for incylinder flow formation
- Published
- 2016
6. Association of glycosylated hemoglobin (HbA1c) levels with Iinsulin resistance in obese children.
- Author
-
Önal, ZE, primary, Atasayan, V, additional, Gürbüz, T, additional, Hepkaya, E, additional, and Nuhoğlu, C, additional
- Published
- 2014
- Full Text
- View/download PDF
7. Home mechanical ventilation in children: The experience of pediatric pulmonology divisions in Istanbul
- Author
-
M Yanaz, F Unal, E Hepkaya, H Yazan, S Can Oksay, E Kostereli, C Yilmaz Yegit, A Kilic Baskan, Z R Onay, A Gulieva, A Soyyigit, M Kalyoncu, H B Kucuk, Y Ayhan, A P Ergenekon, E Atag, S Uzuner, N Bas Ikizoglu, A Ayzit Kilinc, P Ay, E Erdem Eralp, Y Gokdemir, S Oktem, E Cakir, S Girit, Z S Uyan, H Cokugras, R Ersu, B Karadag, F Karakoc, and Yanaz M., Unal F., Hepkaya E., YAZAN H., Oksay S. C., Kostereli E., Yegit C. Y., Baskan A. K., Onay Z. R., Gulieva A., et al.
- Subjects
Pulmonary and Respiratory Medicine ,Internal Medicine Sciences ,Pulmonology ,Klinik Tıp ,Mechanical Ventilation ,RESPIRATORY SYSTEM ,Pediatric Pulmonology ,Dahili Tıp Bilimleri ,Göğüs Hastalıkları ve Allerji ,CLINICAL MEDICINE ,Sağlık Bilimleri ,Clinical Medicine (MED) ,Tıp ,SOLUNUM SİSTEMİ ,Respiratory Care ,Health Sciences ,Akciğer ve Solunum Tıbbı ,Medicine ,Klinik Tıp (MED) ,Chest Diseases and Allergy ,Solunum Bakımı - Abstract
Background: Prolonged survival of patients with chronic respiratory failure increased the number of patients receiving long-term home ventilation (LTHV). This study aimed to describe the aetiology and patterns of the use of LTHV in Istanbul. Methods: This cross-sectional study included children on home invasive ventilation (IV) and non-invasive ventilation (NIV) from six tertiary hospitals. Data including underlying diagnosis and LTHV were collected from patients' charts. Results: Study included 416 patients. The most common diagnoses were neuromuscular (35.1%) and neurological diseases (25.7%). While 49.5% (n=206) received NIV, 50.5% (n=210) of the patients received IV. The median age at initiation of LTHV was lower in the IV group (10 vs. 41 months, p
- Published
- 2022
8. Factors associated with pulmonary function decline of patients in the cystic fibrosis registry of Turkey: A retrospective cohort study.
- Author
-
Emiralioğlu N, Çakır B, Sertçelik A, Yalçın E, Kiper N, Şen V, Altıntaş DU, Serbes M, Çokuğraş H, Kılınç AA, Başkan AK, Hepkaya E, Yazan H, Türel Ö, Kafi HM, Yılmaz Aİ, Ünal G, Çağlar T, Damadoğlu E, Irmak İ, Demir E, Öztürk G, Bingöl A, Başaran E, Sapan N, Aslan AT, Asfuroğlu P, Harmancı K, Köse M, Hangül M, Özdemir A, Tuğcu G, Polat SE, Özcan G, Gayretli ZG, Keskin Ö, Bilgiç S, Yüksel H, Özdoğan Ş, Topal E, Çaltepe G, Can D, Ekren PK, Kılıç M, Süleyman A, Eyüboğlu TŞ, Cinel G, Pekcan S, Çobanoğlu N, Çakır E, Özçelik U, and Doğru D
- Subjects
- Humans, Retrospective Studies, Male, Female, Child, Adolescent, Forced Expiratory Volume, Turkey epidemiology, Risk Factors, Young Adult, Adult, Pseudomonas Infections epidemiology, Pseudomonas Infections physiopathology, Lung physiopathology, Severity of Illness Index, Pseudomonas aeruginosa, Cystic Fibrosis physiopathology, Registries, Disease Progression, Respiratory Function Tests statistics & numerical data
- Abstract
Background: The decline in pulmonary function is a predictor of disease progression in patients with cystic fibrosis (CF). This study aimed to determine the decline rate of percent predicted forced expiratory volume in 1 s (ppFEV1) based on the data of the CF Registry of Turkey. The secondary aim was to investigate the risk factors related to the decline in ppFEV1., Methods: A retrospective cohort study of CF patients over 6 years old, with pulmonary function data over at least 2 years of follow-up was extracted from the national CF registry for years 2017-2019. Patients were classified according to disease severity and age groups. Multivariate analysis was used to predict the decline in ppFEV1 and to investigate the associated risk factors., Results: A total of 1722 pulmonary function test results were available from 574 patients over the study period. Mean diagnostic age was older and weight for age, height for age, and body mass index z scores were significantly lower in the group of ppFEV1 < 40, while chronic Pseudomonas aeruginosa (p < .001) and mucoid P. aeruginosa colonization (p < .001) were significantly higher in this group (p < .001). Overall mean annual ppFEV1 decline was -0.97% (95% confidence interval [CI] = -0.02 to -1.92%). The mean change of ppFEV1 was significantly higher in the group with ppFEV1 ≥ 70 compared with the other (ppFEV1 < 40 and ppFEV1: 40-69) two groups (p = .004). Chronic P. aeruginosa colonization (odds ratio [OR] = 1.79 95% CI = 1.26-2.54; p = .01) and initial ppFEV1 ≥ 70 (OR = 2.98 95% CI = 1.06-8.36), p = .038) were associated with significant ppFEV1 decline in the whole cohort., Conclusions: This data analysis recommends close follow-up of patients with normal initial ppFEV1 levels at baseline; advocates for early interventions for P. aeruginosa; and underlines the importance of nutritional interventions to slow down lung disease progression., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
9. The Role of Telehealth Services in Children with Cystic Fibrosis During Coronavirus Disease 2019 Outbreak.
- Author
-
Beşer ÖF, Karaboğa EPU, Hepkaya E, Kılınç Sakallı AA, Dönmez Türkmen A, Dilek TD, Çokuğraş H, and Çullu Çokuğraş F
- Subjects
- Anxiety epidemiology, Child, Disease Outbreaks, Female, Humans, Male, COVID-19 epidemiology, Cystic Fibrosis epidemiology, Cystic Fibrosis therapy, Telemedicine
- Abstract
Objectives: This study aimed to monitor the health and nutritional status of pediatric cystic fibrosis (CF) patients via telehealth services during the novel coronavirus disease 2019 (COVID-19). Additional aims were to determine the level of anxiety in the patients and their caregivers and to determine the COVID-19 transmission status among CF patients. Materials and Methods: The CF team supported the patients via remote contact. During telehealth services interviews, in addition to obtaining information about the patients' anthropometric measurements, health status, and CF-related complaints, the State-Trait Anxiety Inventory (STAI) was administered to the patients and controls. The Hospital Anxiety and Depression Scale (HAD) was administered to their caregivers. Results: The study included 144 pediatric CF patients (74 males and 70 females). Mean age of the patients was 8.9 years. In all, 42 (29.2%) of the patients were tested for COVID-19, of which 4 were positive. The mean STAI score was significantly lower in the patient group than in the control group ( p < 0.001). The mean HAD anxiety score was significantly higher in the caregivers of the CF patients, compared to the caregivers of the controls ( p = 0.005). In addition, the mean HAD depression score was significantly higher in the caregivers of the CF patients ( p < 0.001). Conclusions: Telehealth is an innovative method for providing health care services while maintaining social distance and avoiding the risk of exposure and spread of COVID-19. Telehealth services reduce patient and parental anxiety and increase the level of confidence in managing CF-related complications.
- Published
- 2022
- Full Text
- View/download PDF
10. Comparisons of Clinical Features and Outcomes of COVID-19 between Patients with Pediatric Onset Inflammatory Rheumatic Diseases and Healthy Children.
- Author
-
Haslak F, Varol SE, Gunalp A, Kaynar O, Yildiz M, Adrovic A, Sahin S, Kes G, Ayzit-Kilinc A, Akdeniz B, Onal P, Apaydin G, Aygun D, Arslan H, Kilic-Baskan A, Hepkaya E, Meral O, Barut K, Cokugras HC, and Kasapcopur O
- Abstract
(1) Background: We aimed to describe the clinical features and outcomes of coronavirus disease-2019 (COVID-19) in children and late adolescents with inflammatory rheumatic diseases (IRD) and to measure their severity risks by comparing them with healthy children. (2) Methods: Among children and late adolescents found to be severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) positive via polymerase chain reaction (PCR) test, IRD patients with an at least six-months follow-up duration, and healthy children were included in the study. Data were obtained retrospectively. (3) Results: A total of 658 (339 (51.5%) females) (healthy children: 506, IRD patients: 152) subjects were included in the study. While 570 of 658 (86.6%) experienced COVID-19-related symptoms, only 21 (3.19%) required hospitalization with a median duration of 5 (1-30) days. Fever, dry cough, and fatigue were the most common symptoms. None of evaluated subjects died, and all recovered without any significant sequelae. The presence of any IRD was found to increase the risk of both hospitalization (OR: 5.205; 95% CI: 2.003-13.524) and symptomatic infection (OR: 2.579; 95% CI: 1.068-6.228). Furthermore, increasing age was significantly associated with symptomatic infection (OR: 1.051; 95% CI: 1.009-1.095). (4) Conclusions: Our study emphasizes that pediatric rheumatologists should monitor their patients closely for relatively poor COVID-19 outcomes.
- Published
- 2022
- Full Text
- View/download PDF
11. Efficacy of standardized tracheostomy training with a simulation model for healthcare providers: A study by ISPAT team.
- Author
-
Uyan ZS, Atag E, Ergenekon AP, Gokdemir Y, Gokler O, Ay P, Bas İkizoglu N, Cenk M, Erdem Eralp E, Sivrikaya GU, Girit S, Cakir E, Kilic AA, Yazan H, Can Oksay S, Hepkaya E, Kiyan G, Karadag B, Karakoc F, and Oktem S
- Subjects
- Child, Clinical Competence, Computer Simulation, Humans, Health Personnel education, Tracheostomy education
- Abstract
Introduction: Tracheostomy care in children may be challenging, due to lack of knowledge of healthcare providers (HCPs). The aim of this study was to determine the level of knowledge of HCP who follow patients with tracheostomy and to increase this level with theoretical training and training in a simulation laboratory., Materials and Methods: ISPAT (IStanbul PAediatric Tracheostomy), a multidisciplinary team for tracheostomy care was established and a training program was prepared. Participants were subjected to theoretical and practical pretests which evaluated their knowledge levels and skills for care, follow-up, and treatment of a patient with tracheostomy. After the theoretical and practical training given to the participants with a simulation model, theoretical and practical posttests were applied., Results: Fifty-one HCP from nine tertiary pediatric clinics in Istanbul were enrolled in the training program. Only six (11.8%) of them had received standardized training programs previously. Regarding the theoretical tests, seven of the 33 questions were indicated as essential. The knowledge level of the participants based on the essential questions significantly increased after the training (p < 0.05 for all of the essential questions). The total number of correct answers and correct answers of three subheadings also significantly increased after the practical training (p < 0.001 for all). Ninety-five percent of the participants assessed the course as good or excellent in general., Conclusion: Training in a simulation laboratory in combination with theoretical education can improve the knowledge and skills of the HCP enabling improved care of children with a tracheostomy., (© 2021 Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
- View/download PDF
12. The effects of nusinersen treatment on respiratory status of children with spinal muscular atrophy.
- Author
-
Hepkaya E, Kılınç Sakallı AA, Ülkersoy İ, Başkan AK, Arslan H, Meral Ö, Dilek TD, Güler S, Saltık S, and Çokuğraş H
- Subjects
- Child, Infant, Humans, Child, Preschool, Oligonucleotides therapeutic use, Injections, Spinal, Muscular Atrophy, Spinal drug therapy, Spinal Muscular Atrophies of Childhood drug therapy
- Abstract
Background: Respiratory involvement is the main factor predicting the prognosis of spinal muscular atrophy (SMA). Significant responses in motor functions have been demonstrated with nusinersen, but pulmonary outcomes are still varied. We aimed to explore the effects of nusinersen on the respiratory functions of patients with SMA., Methods: Patients with SMA who were receiving regular nusinersen treatment in our tertiary care hospital were enrolled in this study. We evaluated the patients in terms of the necessity to ventilatory or nutritional support, presence of motor involvement and other comorbidities related with prognosis at three consecutive assessments., Results: The study group consisted of 43 patients (18 type 1, 12 type 2, and 13 type 3) with SMA with a mean age of 27.8 months at diagnosis and 60.8 months at the beginning of nusinersen treatment. The respiratory function improvements were noted in six patients at third assessment. Early initiation of nusinersen was significantly correlated with reduced hospital admissions (P = 0.026). Nutritional support and weight gain were remarkable in the ventilatory-supported group. Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scores were significantly higher in the non-tracheostomized group in patients with SMA type 1 (P < 0.005)., Conclusions: We posit that nusinersen may change the natural prognosis of SMA and improve care of children with SMA. Following up children with SMA for longer periods under nusinersen may be beneficial for understanding the effects of treatment. Results of our study need to be supported by future long-term studies to reach a consensus on nusinersen, considering the overall genetic and environmental status as well as the cost-effectiveness of the treatment., (© 2022 Japan Pediatric Society.)
- Published
- 2022
- Full Text
- View/download PDF
13. The Effects of the COVID-19 Pandemic on Pediatric Cystic Fibrosis Patients.
- Author
-
Beşer ÖF, Uğur Karaboğa EP, Hepkaya E, Kılınç Sakallı AA, Dönmez Türkmen A, Dilek TD, Çokuğraş H, and Çullu Çokuğraş F
- Subjects
- Child, Humans, Pandemics, SARS-CoV-2, COVID-19, Cystic Fibrosis epidemiology
- Published
- 2021
- Full Text
- View/download PDF
14. General health status of children with asthma during the COVID-19 pandemic.
- Author
-
Hepkaya E, Kilinc AA, Cebi MN, Koyuncu Z, and Cokugras H
- Subjects
- Adolescent, Anxiety epidemiology, Attitude to Health, Child, Child, Preschool, Female, Health Personnel, Histamine Antagonists therapeutic use, Humans, Male, Pandemics, Parents psychology, SARS-CoV-2, Surveys and Questionnaires, Asthma epidemiology, Asthma therapy, COVID-19 epidemiology, Health Status
- Abstract
Background: Since the COVID-19 pandemic became a serious health concern globally, patients with chronic diseases have required close attention with regard to general risks and individual treatment. We aimed to reveal the general health status of pediatric asthmatic patients during the pandemic, considering the role of household factors in parental attitudes., Methods: We asked 60 asthmatic patients and their parents to respond to a questionnaire, with the aim of revealing the current health status of the patients and the general approach of the family to asthma management during the pandemic., Results: A total of eight patients had had an asthma attack during the outbreak, but there was no confirmed correlation with COVID-19 infection. Most of the parents had never considered stopping their children's current medications. However, the majority of them reported concerns about the failure of the ambulatory care services and almost all saw their children as being at high risk for COVID-19 infection. There was no significant relationship between these concerns and their psychological status (P > 0.05)., Conclusions: The crucial point regarding asthma management is to control patients' medical and psychological status to minimize the effects of the pandemic. Healthcare professionals should also pay attention to members of the patients' households because their adaptation to the "new normal" of pandemic may directly affect the patients' state of health., (© 2020 Japan Pediatric Society.)
- Published
- 2021
- Full Text
- View/download PDF
15. Immunomodulator effect of topical zinc oxide application in tuberculin skin test.
- Author
-
Nuhoglu C, Hepkaya E, Onal ZE, Akici N, Gurbuz T, Atasayan V, and Ceran O
- Abstract
Objective: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability., Methods: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later., Results: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels., Conclusion: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.