95 results on '"Hepatic Mesenchymal Hamartoma"'
Search Results
2. Outcomes of Primary Tumor Excision do not Differ from Non-Resection Methods in Pediatric Mesenchymal Hamartoma of the Liver: A Rapid Systematic Review.
- Author
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Bauzon, Justin, Froehlich, Mary, Dadon, Noam, Morris, Desiree, and Chang, Shirong
- Abstract
To conduct a rapid systematic review comparing the outcomes of primary tumor resection versus non-resection on patients with hepatic mesenchymal hamartoma. We searched the Ovid MEDLINE, EMBASE, Scopus, PubMed, Web of Science, and Google Scholar databases from January 1, 2000 to March 31, 2022. Studies that described cases of hepatic mesenchymal hamartoma, including management and outcomes, were included. 62 articles met inclusion criteria with 95 cases in total. Patients were assigned to the primary tumor resection (n = 85) or non-resection (n = 10) cohort based on the described management. Similar rates of morbidity (17% vs 20%) and mortality (6 vs 10%) were identified between cohorts. There were no differences in sex, liver lobe involvement, or tumor size among study groups. Complete tumor resection should remain the gold standard for hepatic mesenchymal hamartomas when an adequate liver remnant exists. Reports of non-resected tumors demonstrating spontaneous regression or stability with watchful waiting have poor long term follow-up and have inadequate evidence of a true mesenchymal hamartoma diagnosis. Level I. • Hepatic mesenchymal hamartoma is a common benign liver mass in pediatric patients with varied surgical management described in the literature. • Complete tumor resection should remain the gold standard with a recommendation against watchful waiting, regardless of mass size. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Hepatic mesenchymal hamartoma masquerading as neonatal unconjugated hyperbilirubinemia: a case report
- Author
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Shirbin Joe Mathews, Athiya Perveen K, Bini Mariam Chandy, and Ria K. Mathew
- Subjects
Hepatic mesenchymal hamartoma ,Neonatal jaundice ,Neonatal unconjugated hyperbilirubinemia ,Benign hepatic tumor ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Hepatic mesenchymal hamartoma (HMH) is the second most common benign hepatic tumor in the pediatric age group. The etiology of HMH is unclear. Theories include abnormal hepatic mesenchyme, a reactive change or a proliferative lesion. The condition can present prenatally in USG as a mass, high output cardiac failure, pulmonary hypertension, respiratory distress, and abdominal distension or mass in older children. We present this case to discuss an extremely rare presentation of a comparatively rare disease and to emphasise the need for a high index of suspicion even if the patient presents with symptoms common for that age. Case presentation A 7-day-old male baby with an uneventful antenatal period, born by vaginal delivery, with a birth weight of 3.1 kg and normal APGAR scores, presented with jaundice, poor feeding, and labored breathing noticed on the same day itself. Examination revealed a grossly distended abdomen with a mass of size 8 × 7 cm occupying the right side down to the right iliac fossa, crossing midline and dullness continuous with liver dullness. On investigation an abnormal liver function test with unconjugated hyperbilirubinemia was seen. USG and CECT abdomen were suggestive of HMH with close proximity to hepatic vessels. Exploratory laparotomy and near total excision with marsupialisation was done. Histopathology report was suggestive of HMH. A 2-year follow-up was normal. Conclusion This case of HMH presented as neonatal jaundice with unconjugated hyperbilirubinemia which is a rarity. We had to limit our surgery to near total excision and marsupialisation due to its proximity to vascular structures.
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- 2023
- Full Text
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4. Hepatic mesenchymal hamartoma masquerading as neonatal unconjugated hyperbilirubinemia: a case report.
- Author
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Mathews, Shirbin Joe, Perveen K, Athiya, Chandy, Bini Mariam, and Mathew, Ria K.
- Subjects
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NEONATAL jaundice , *HAMARTOMA , *INFANTS , *DELIVERY (Obstetrics) , *DYSPNEA , *LIVER function tests - Abstract
Background: Hepatic mesenchymal hamartoma (HMH) is the second most common benign hepatic tumor in the pediatric age group. The etiology of HMH is unclear. Theories include abnormal hepatic mesenchyme, a reactive change or a proliferative lesion. The condition can present prenatally in USG as a mass, high output cardiac failure, pulmonary hypertension, respiratory distress, and abdominal distension or mass in older children. We present this case to discuss an extremely rare presentation of a comparatively rare disease and to emphasise the need for a high index of suspicion even if the patient presents with symptoms common for that age. Case presentation: A 7-day-old male baby with an uneventful antenatal period, born by vaginal delivery, with a birth weight of 3.1 kg and normal APGAR scores, presented with jaundice, poor feeding, and labored breathing noticed on the same day itself. Examination revealed a grossly distended abdomen with a mass of size 8 × 7 cm occupying the right side down to the right iliac fossa, crossing midline and dullness continuous with liver dullness. On investigation an abnormal liver function test with unconjugated hyperbilirubinemia was seen. USG and CECT abdomen were suggestive of HMH with close proximity to hepatic vessels. Exploratory laparotomy and near total excision with marsupialisation was done. Histopathology report was suggestive of HMH. A 2-year follow-up was normal. Conclusion: This case of HMH presented as neonatal jaundice with unconjugated hyperbilirubinemia which is a rarity. We had to limit our surgery to near total excision and marsupialisation due to its proximity to vascular structures. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Mesenchymal hamartoma of the liver incidentally discovered in a 4 year old girl: Management and treatment
- Author
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Sameh Tlili, Malak Boughdir, Aida Daib, Youssef Hellal, Ehsen Ben Brahim, Nejib Kaabar, and Rabiaa Ben Abdallah
- Subjects
hepatic mesenchymal hamartoma ,paediatric liver tumours ,paediatric surgery ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Mesenchymal hamartomas of the liver is considered a benign tumour, although it provides significant challenges in the diagnosis and operative management. Clinical features, laboratory results and radiographic imaging are often non-specific and inconclusive. Thus, it is still difficult to differentiate from malignant lesion without pathological examination. While this tumour is usually diagnosed in the first 2 years of life, few cases in older children have been reported and most of them are case reports. In this article, we want to report our clinical evaluation, results of image diagnosis, surgical procedure and the follow-up simultaneously we discuss the possible differential diagnosis of such a case at this age.
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- 2023
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6. Infantile hepatic hemangioma and hepatic mesenchymal hamartoma in an infant associated with placental mesenchymal dysplasia: a case report
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Shunsuke Fujii, Kyoko Mochizuki, Hidehito Usui, Norihiko Kitagawa, Sayoko Umemoto, Mio Tanaka, Yukichi Tanaka, Masako Otani, Kumiko Nozawa, Kenji Kurosawa, Masayo Kagami, and Masato Shinkai
- Subjects
Hepatic infantile hemangioma ,Hepatic mesenchymal hamartoma ,Placental mesenchymal dysplasia ,Propranolol ,Tumorectomy ,Surgery ,RD1-811 - Abstract
Abstract Background Although infantile hepatic hemangioma and hepatic mesenchymal hamartoma are relatively common in benign pediatric liver tumors, coexistence of the two tumors is rare. Placental mesenchymal dysplasia is also a rare disorder. We report the case of a baby girl born after a pregnancy complicated by placental mesenchymal dysplasia, who developed both infantile hepatic hemangioma and hepatic mesenchymal hamartoma. Case presentation The patient was born at 32 weeks and 5 days of gestation for impending placental abruption, weighing 1450 g. Liver tumors, composed of both hypervascular solid and large cystic lesions, were detected after birth and markedly increased to create abdominal distention within 9 months. Diagnostic imaging suspected the coexistence of infantile hepatic hemangioma and cystic hepatic mesenchymal hamartoma. Following propranolol therapy for infantile hepatic hemangioma and needle puncture of a large cyst, the cystic lesions and adjacent hypervascular lesions were partially resected via laparotomy. Pathological findings confirmed the coexistence of hepatic mesenchymal hamartoma and infantile hepatic hemangioma, which had no association with androgenetic/biparental mosaicism. The postoperative course was uneventful, and the tumor had not regrown after 3 years. Conclusions Although the coexistence of infantile hepatic hemangioma and hepatic mesenchymal hamartoma associated with placental mesenchymal dysplasia is extremely rare, the pathological and pathogenetic similarities between these disorders suggest that they could have derived from similar embryologic origins rather than being a mere coincidence. Further follow-up is required, with careful attention to the potential for malignant hepatic mesenchymal hamartoma transformation.
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- 2022
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7. 良性肝脏肿瘤肝移植相关进展.
- Author
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倪远之 and 张武
- Abstract
Liver tumors can be divided into benign and malignant types. Benign liver tumors are relatively common, which are mainly treated with follow-up observation and interventional therapy, and surgical resection should be performed for few cases. Liver transplantation can effectively treat end-stage liver diseases, whereas it is seldom applied in the treatment of benign liver tumors. Liver transplantation is only considered for benign liver tumors with huge space-occupying compression, liver failure, the risk of tumor rupture and bleeding or malignant transformation. Compared with malignant tumors and chronic liver failure, liver transplantation yields an equivalent risk for benign liver tumors, favorable clinical prognosis and long-term survival. However, comprehensive evaluation should be delivered before liver transplantation for benign liver tumors, and extensive attention should be paid to the difficulty of donor liver matching in the new situation. In this article, research progress on liver transplantation for benign liver tumors including hepatic hemangioma, polycystic liver, hepatocellular adenoma, hepatic mesenchymal hamartoma was reviewed, aiming to provide reference for liver transplantation in the treatment of benign liver tumors. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Infantile hepatic hemangioma and hepatic mesenchymal hamartoma in an infant associated with placental mesenchymal dysplasia: a case report.
- Author
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Fujii, Shunsuke, Mochizuki, Kyoko, Usui, Hidehito, Kitagawa, Norihiko, Umemoto, Sayoko, Tanaka, Mio, Tanaka, Yukichi, Otani, Masako, Nozawa, Kumiko, Kurosawa, Kenji, Kagami, Masayo, and Shinkai, Masato
- Subjects
HAMARTOMA ,HEMANGIOMAS ,DYSPLASIA ,PLACENTA ,LIVER tumors ,ABRUPTIO placentae - Abstract
Background: Although infantile hepatic hemangioma and hepatic mesenchymal hamartoma are relatively common in benign pediatric liver tumors, coexistence of the two tumors is rare. Placental mesenchymal dysplasia is also a rare disorder. We report the case of a baby girl born after a pregnancy complicated by placental mesenchymal dysplasia, who developed both infantile hepatic hemangioma and hepatic mesenchymal hamartoma. Case presentation: The patient was born at 32 weeks and 5 days of gestation for impending placental abruption, weighing 1450 g. Liver tumors, composed of both hypervascular solid and large cystic lesions, were detected after birth and markedly increased to create abdominal distention within 9 months. Diagnostic imaging suspected the coexistence of infantile hepatic hemangioma and cystic hepatic mesenchymal hamartoma. Following propranolol therapy for infantile hepatic hemangioma and needle puncture of a large cyst, the cystic lesions and adjacent hypervascular lesions were partially resected via laparotomy. Pathological findings confirmed the coexistence of hepatic mesenchymal hamartoma and infantile hepatic hemangioma, which had no association with androgenetic/biparental mosaicism. The postoperative course was uneventful, and the tumor had not regrown after 3 years. Conclusions: Although the coexistence of infantile hepatic hemangioma and hepatic mesenchymal hamartoma associated with placental mesenchymal dysplasia is extremely rare, the pathological and pathogenetic similarities between these disorders suggest that they could have derived from similar embryologic origins rather than being a mere coincidence. Further follow-up is required, with careful attention to the potential for malignant hepatic mesenchymal hamartoma transformation. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
9. A rapidly growing mesenchymal hamartoma in a neonate with known placental anomalies
- Author
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Justin Bauzon, Desiree Morris, Charles St. Hill, Taylor Schanda, Michael Scheidler, and Shirong Chang
- Subjects
Hepatic mesenchymal hamartoma ,Benign liver tumor ,Rapid growth ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Hepatic mesenchymal hamartomas (HMH) are benign liver lesions that present as cystic, slow growing masses within the first few years of life. Few cases demonstrate placental abnormalities and abnormal levels of alpha-fetoprotein (AFP). We report an unusual case of a rapidly growing HMH with associated placental anomalies and elevated AFP. A 2-month-old female born prematurely due to concerning placental findings presented with a prenatally-identified liver mass. Magnetic resonance imaging (MRI) showed a marked increase in the size of the mass over a three-month period. Prior to surgery, the AFP was elevated and decreased after operative resection. Histopathology confirmed the diagnosis HMH. Rapid growth of HMH is not commonly reported and raises concerns for malignancy. Abnormal placental findings may lead to prematurity, which can affect surgical management. We identified 27 cases of prenatally diagnosed HMH since 1983. The mean gestational age for identification was 29 weeks, with the majority managed by delayed resection. The timing for surgical intervention lacks consensus, but malnutrition and perioperative complications should be considered. High AFP levels with an infantile hepatic mass may indicate a more malignant process but does not exclude HMH.
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- 2022
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10. Clinicopathological study of hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a single center study from Iran
- Author
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Parham Habibzadeh, Mohaddese Ansari Asl, Hamid Reza Foroutan, Ali Bahador, and Mohammad Hossein Anbardar
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Undifferentiated embryonal sarcoma of the liver ,Hepatic mesenchymal hamartoma ,Liver neoplasms ,Immunohistochemistry ,Pathology, surgical ,CD56 antigen ,Pathology ,RB1-214 - Abstract
Abstract Background Undifferentiated embryonal sarcoma of liver (UESL) and hepatic mesenchymal hamartoma (HMH) are two rare entities which mainly affect the pediatric population. The aim of this investigation was to provide a comprehensive overview of the clinicopathologic characteristics of the patients diagnosed with these two conditions in a tertiary referral center in Iran. Methods In this retrospective study patients diagnosed with UESL or HMH between 2012 and 2020 were studied. A comprehensive histopathologic evaluation of the cases along with immunohistochemistry evaluation using a panel of antibodies was conducted. Furthermore, clinical, paraclinical, and treatment data and follow up information was collected. Results A total of 16 patients (8 UESL, 8 HMH) were studied in this investigation. Patients with UESL had a significantly (p = 0.002) higher age at diagnosis compared with those with HMH. Histologically, UESL cases were characterized by anaplastic cells with eosinophilic cytoplasm and bizarre nuclei and frequent atypical mitosis and spindling in a myxoid stroma while disordered arrangement of hepatic parenchyma, bile ducts, and primitive mesenchyme was seen in HMH. Furthermore, small round cells and extramedullary hematopoiesis were seen in 2 UESL and 3 HMH cases, respectively. Concurrent HMH was also seen in two UESL cases. Immunohistochemistry panel showed positive staining for Vimentin, Glypican-3, Desmin, CD56, CD10, and BCL2 in UESL cases and immunoreactivity for Vimentin, HepPar 1, Glypican-3, SMA, CD56, BCL2, and CD34 in various components of HMH. Conclusions In this study, the clinicopathologic features of UESL and HMH cases are presented. We also evaluated the utility of an immunohistochemistry panel in the diagnosis of these two rare entities and suggested novel markers. Our study corroborated the findings of previous investigations and expanded the clinicopathologic features of these two rare entities with diagnostic and potential therapeutic implications.
- Published
- 2021
- Full Text
- View/download PDF
11. Displasia mesenquimal placentaria asociada con restricción del crecimiento intrauterino de inicio temprano: reporte de un caso.
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Salcedo-González, Alejandra, Noé Nava-Guerrero, Eduardo, Rodríguez-Segovia, Gabriela, Arroyo-Lemarroy, Tayde, Cisneros-Rivera, Fidel, and Perales-Dávila, José
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DYSPLASIA ,PLACENTA development ,FETAL development ,HAMARTOMA ,PREGNANT women ,PERINATAL death - Abstract
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- 2022
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12. Hepatic mesenchymal hamartoma: The role of radiology in diagnosis and management
- Author
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Tran Phan Ninh, MD, PhD, Truong Quang Dinh, MD, PhD, Thieu-Thi Tra My, MD, Bui Khac Hieu, MD, Luong Viet Bang, MD, and Nguyen Minh Duc, MD, MSc
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Hepatic mesenchymal hamartoma ,Hepatic cystic lesion ,Liver abscess ,Hepatic tumor ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Hepatic mesenchymal hamartoma is an uncommon tumor composed of myxoid mesenchymal tissue with fluid accumulation. Here, we report a case of hepatic mesenchymal hamartoma in a 3-year-old patient who was referred to the hospital with abdominal pain and a slight fever. An abdominal ultrasound suggested a liver abscess; however, computed tomography revealed a mass with both cystic and solid components. Liver biopsy confirmed hepatic mesenchymal hamartoma, and this patient underwent the complete removal of this tumor.
- Published
- 2021
- Full Text
- View/download PDF
13. Clinicopathological study of hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a single center study from Iran.
- Author
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Habibzadeh, Parham, Ansari Asl, Mohaddese, Foroutan, Hamid Reza, Bahador, Ali, and Anbardar, Mohammad Hossein
- Subjects
- *
HAMARTOMA , *EXTRAMEDULLARY hematopoiesis , *SARCOMA , *LIVER , *DIAGNOSIS , *INTRAHEPATIC bile ducts , *CYTOPLASM , *HEMATOPOIESIS - Abstract
Background: Undifferentiated embryonal sarcoma of liver (UESL) and hepatic mesenchymal hamartoma (HMH) are two rare entities which mainly affect the pediatric population. The aim of this investigation was to provide a comprehensive overview of the clinicopathologic characteristics of the patients diagnosed with these two conditions in a tertiary referral center in Iran. Methods: In this retrospective study patients diagnosed with UESL or HMH between 2012 and 2020 were studied. A comprehensive histopathologic evaluation of the cases along with immunohistochemistry evaluation using a panel of antibodies was conducted. Furthermore, clinical, paraclinical, and treatment data and follow up information was collected. Results: A total of 16 patients (8 UESL, 8 HMH) were studied in this investigation. Patients with UESL had a significantly (p = 0.002) higher age at diagnosis compared with those with HMH. Histologically, UESL cases were characterized by anaplastic cells with eosinophilic cytoplasm and bizarre nuclei and frequent atypical mitosis and spindling in a myxoid stroma while disordered arrangement of hepatic parenchyma, bile ducts, and primitive mesenchyme was seen in HMH. Furthermore, small round cells and extramedullary hematopoiesis were seen in 2 UESL and 3 HMH cases, respectively. Concurrent HMH was also seen in two UESL cases. Immunohistochemistry panel showed positive staining for Vimentin, Glypican-3, Desmin, CD56, CD10, and BCL2 in UESL cases and immunoreactivity for Vimentin, HepPar 1, Glypican-3, SMA, CD56, BCL2, and CD34 in various components of HMH. Conclusions: In this study, the clinicopathologic features of UESL and HMH cases are presented. We also evaluated the utility of an immunohistochemistry panel in the diagnosis of these two rare entities and suggested novel markers. Our study corroborated the findings of previous investigations and expanded the clinicopathologic features of these two rare entities with diagnostic and potential therapeutic implications. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
14. Hepatic mesenchymal hamartoma: An uncommon but important paediatric diagnosis
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Sheree C. Gray, Jacobus A. Pienaar, Zelia Sofianos, Jacob Varghese, and Ilonka Warnich
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hepatic mesenchymal hamartoma ,paediatric population ,cystic liver masses ,hepatic tumours ,paediatric alfa fetoprotein levels ,computed tomography ,ultrasound ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Hepatic mesenchymal hamartoma is a rare hepatic tumour seen in the paediatric population. Although this entity has a variable imaging appearance, it has a favourable prognosis if diagnosed and managed correctly. This case presents the ultrasound and computed tomography findings of an 11-month-old patient who presented with a history of progressive abdominal distension and an elevated alfa fetoprotein level on biochemistry. The case describes how a confident perioperative diagnosis could be made on the basis of characteristic imaging features.
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- 2020
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15. Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review
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Sebastiao N Martins-Filho and Juan Putra
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C19MC ,hepatic mesenchymal hamartoma ,hepatic neoplasm ,MALAT1 ,malignant transformation ,pediatric liver tumors ,Diseases of the digestive system. Gastroenterology ,RC799-869 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
This review highlights two rare entities that are predominantly seen in children: hepatic mesenchymal hamartoma (HMH) and undifferentiated embryonal sarcoma of the liver (UESL). HMH is a benign lesion predominantly seen in the first 2 years of life, while UESL is malignant and usually identified in patients between 6 and 10 years of age. UESL may arise in the background of HMH, and the association has been supported by similar chromosomal aberrations (19q13.4). The diagnosis of both lesions is primarily based on histologic evaluation, as the clinical and radiological features are not always typical. The clinicopathologic characteristics, pathogenesis, differential diagnoses and treatment for both lesions are discussed.
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- 2020
- Full Text
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16. Hepatic mesenchymal hamartoma: An uncommon but important paediatric diagnosis.
- Author
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Gray, Sheree C., Pienaar, Jacobus A., Sofianos, Zelia, Varghese, Jacob, and Warnich, Ilonka
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DIFFERENTIAL diagnosis ,LIVER ,LIVER tumors ,TUMORS in children ,HAMARTOMA - Abstract
Hepatic mesenchymal hamartoma is a rare hepatic tumour seen in the paediatric population. Although this entity has a variable imaging appearance, it has a favourable prognosis if diagnosed and managed correctly. This case presents the ultrasound and computed tomography findings of an 11-month-old patient who presented with a history of progressive abdominal distension and an elevated alfa fetoprotein level on biochemistry. The case describes how a confident perioperative diagnosis could be made on the basis of characteristic imaging features. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
17. Hepatic mesenchymal hamartoma: The role of radiology in diagnosis and management
- Author
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Luong Viet Bang, Truong Quang Dinh, Nguyen Minh Duc, Bui Khac Hieu, Thieu-Thi Tra My, and Tran Phan Ninh
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Abdominal pain ,Abdominal ultrasound ,R895-920 ,Case Report ,Hepatic tumor ,030218 nuclear medicine & medical imaging ,Medical physics. Medical radiology. Nuclear medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Fluid accumulation ,medicine.diagnostic_test ,business.industry ,Mesenchymal stem cell ,medicine.disease ,Hepatic cystic lesion ,Slight fever ,Liver abscess ,Hepatic Mesenchymal Hamartoma ,Liver biopsy ,Radiology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Hepatic mesenchymal hamartoma - Abstract
Hepatic mesenchymal hamartoma is an uncommon tumor composed of myxoid mesenchymal tissue with fluid accumulation. Here, we report a case of hepatic mesenchymal hamartoma in a 3-year-old patient who was referred to the hospital with abdominal pain and a slight fever. An abdominal ultrasound suggested a liver abscess; however, computed tomography revealed a mass with both cystic and solid components. Liver biopsy confirmed hepatic mesenchymal hamartoma, and this patient underwent the complete removal of this tumor.
- Published
- 2021
18. Giant Mesenchymal Hepatic Hamartomas With Adrenal Involvement Precipitating Respiratory Failure: A Myxomatous Mystery in a Three-Month-Old.
- Author
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Yasback A, Ulhaque A, and Chandra T
- Abstract
The combination of placental mesenchymal dysplasia and hepatic mesenchymal hamartomas is an extremely rare finding. We present the case of a three-month-old female born at 35 weeks gestation with a history of placental mesenchymal dysplasia who presented with non-bilious, non-bloody emesis, and episodes of respiratory distress due to multiple enlarging abdominal cystic lesions. The patient's presentation was unique due to both liver and adrenal solid and cystic lesions. After extensive imaging and multiple biopsies, expert interpretation of biopsy tissue revealed hepatic mesenchymal hamartoma within the liver and the adrenal gland. To our knowledge, this is one of the few documented cases of unresectable hepatic mesenchymal hamartomas with adrenal involvement successfully undergoing a whole liver transplant., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Yasback et al.)
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- 2023
- Full Text
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19. Clinicopathological study of hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a single center study from Iran
- Author
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Ali Bahador, Mohammad Hossein Anbardar, Parham Habibzadeh, Hamid Reza Foroutan, and Mohaddese Ansari Asl
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Histology ,Adolescent ,Hamartoma ,Mesenchyme ,CD56 antigen ,CD34 ,Soft Tissue Neoplasms ,Vimentin ,Pathology, surgical ,Pediatric liver tumors ,Pathology and Forensic Medicine ,Undifferentiated embryonal sarcoma of the liver ,Liver neoplasms ,Eosinophilic ,Biomarkers, Tumor ,medicine ,Undifferentiated (Embryonal) Sarcoma ,Humans ,RB1-214 ,Child ,biology ,business.industry ,Research ,Infant ,Sarcoma ,General Medicine ,Neoplasms, Germ Cell and Embryonal ,medicine.disease ,Immunohistochemistry ,Extramedullary hematopoiesis ,medicine.anatomical_structure ,Liver ,Child, Preschool ,biology.protein ,business ,Hepatic mesenchymal hamartoma - Abstract
Background Undifferentiated embryonal sarcoma of liver (UESL) and hepatic mesenchymal hamartoma (HMH) are two rare entities which mainly affect the pediatric population. The aim of this investigation was to provide a comprehensive overview of the clinicopathologic characteristics of the patients diagnosed with these two conditions in a tertiary referral center in Iran. Methods In this retrospective study patients diagnosed with UESL or HMH between 2012 and 2020 were studied. A comprehensive histopathologic evaluation of the cases along with immunohistochemistry evaluation using a panel of antibodies was conducted. Furthermore, clinical, paraclinical, and treatment data and follow up information was collected. Results A total of 16 patients (8 UESL, 8 HMH) were studied in this investigation. Patients with UESL had a significantly (p = 0.002) higher age at diagnosis compared with those with HMH. Histologically, UESL cases were characterized by anaplastic cells with eosinophilic cytoplasm and bizarre nuclei and frequent atypical mitosis and spindling in a myxoid stroma while disordered arrangement of hepatic parenchyma, bile ducts, and primitive mesenchyme was seen in HMH. Furthermore, small round cells and extramedullary hematopoiesis were seen in 2 UESL and 3 HMH cases, respectively. Concurrent HMH was also seen in two UESL cases. Immunohistochemistry panel showed positive staining for Vimentin, Glypican-3, Desmin, CD56, CD10, and BCL2 in UESL cases and immunoreactivity for Vimentin, HepPar 1, Glypican-3, SMA, CD56, BCL2, and CD34 in various components of HMH. Conclusions In this study, the clinicopathologic features of UESL and HMH cases are presented. We also evaluated the utility of an immunohistochemistry panel in the diagnosis of these two rare entities and suggested novel markers. Our study corroborated the findings of previous investigations and expanded the clinicopathologic features of these two rare entities with diagnostic and potential therapeutic implications.
- Published
- 2021
20. The Cystic Hepatic Mesenchymal Hamartoma in an Adult Mistaken for Hydatid Disease: Case Report
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Habibollah Dashti, Mehran Arab Ahmadi, Niloofar Ayoobi Yazdi, Selda Behestani, Faeze Salahshour, Moneereh Moayeri, and Masoomeh Safaei
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congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Pathology ,business.industry ,Solid mass ,Disease ,Liver Mesenchymal Hamartoma ,Mesenchymal hamartoma ,Albendazole ,03 medical and health sciences ,0302 clinical medicine ,Hepatic Mesenchymal Hamartoma ,030220 oncology & carcinogenesis ,medicine ,030211 gastroenterology & hepatology ,Radiology, Nuclear Medicine and imaging ,Histopathology ,Hepatic tumor ,business ,medicine.drug - Abstract
Hydatid cyst is one of the predominantly cystic liver lesions and is also a zoonotic disease that is highly endemic in the Mediterranean region. This condition has extensive differential diagnoses, such as hepatic mesenchymal hamartoma, a rare benign hepatic tumor, which commonly occurs in infants and children, and is extremely rare in adults. Its imaging findings vary from a cystic tumor to a solid mass occupying one or both lobes of the liver. We report an unusual case of a purely cystic mesenchymal hamartoma of the liver in a 60-year-old female patient. The patient had been treated with albendazole for several years; however, the final histopathology revealed mesenchymal hamartoma.
- Published
- 2021
21. ADULT HEPATIC MESENCHYMAL HAMARTOMA: A CASE REPORT
- Author
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Ahmed Elguazzar
- Subjects
Pathology ,medicine.medical_specialty ,Hepatic Mesenchymal Hamartoma ,business.industry ,medicine ,business - Published
- 2019
22. Clinical Presentation and Anatopathologic Finding of a Hepatic Vascular Hamartoma: a Case Report
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Eduardo Diaz, Benedetto Ielpo, Yolanda Quijano, Emilio Vicente, Valentina Ferri, Hipolito Duran, Isabel Fabra, and Carlos Plaza
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Pathology ,medicine.medical_specialty ,040301 veterinary sciences ,Vascular Hamartoma ,Biopsy ,Hamartoma ,Specialties of internal medicine ,Benign tumor ,Tumor like malformation ,Diagnosis, Differential ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,Gastro ,Case report ,medicine ,Hepatectomy ,Humans ,Vascular tissue ,Hepatology ,business.industry ,Liver Diseases ,04 agricultural and veterinary sciences ,General Medicine ,Middle Aged ,medicine.disease ,Hepatic ligament ,Liver ,RC581-951 ,Hepatic Mesenchymal Hamartoma ,030220 oncology & carcinogenesis ,Female ,Presentation (obstetrics) ,Differential diagnosis ,Tomography, X-Ray Computed ,business ,Vascular hamartoma ,Benign liver tumor - Abstract
HVH (hepatic vascular hamartoma) is a tumor like malformation arising from the vascular tissue of the liver. HVH has been previously reported in animals and presents distintive features from the most frequent benign tumor like malformation of the liver, the hepatic mesenchymal hamartoma (HMH). Herein we report a case of HVH localized in hepatic segment 4b, involving the gastro hepatic ligament, successfully treated with total excision. We describe the anatomo-pathologic findings focusing on the clinical and radiological presentation, the intraoperative characteristics and the differential diagnosis.
- Published
- 2019
23. A rapidly growing mesenchymal hamartoma in a neonate with known placental anomalies.
- Author
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Bauzon, Justin, Morris, Desiree, St. Hill, Charles, Schanda, Taylor, Scheidler, Michael, and Chang, Shirong
- Subjects
HAMARTOMA ,PLACENTA ,MAGNETIC resonance imaging ,LIVER tumors ,NEWBORN infants ,BENIGN tumors - Abstract
Hepatic mesenchymal hamartomas (HMH) are benign liver lesions that present as cystic, slow growing masses within the first few years of life. Few cases demonstrate placental abnormalities and abnormal levels of alpha-fetoprotein (AFP). We report an unusual case of a rapidly growing HMH with associated placental anomalies and elevated AFP. A 2-month-old female born prematurely due to concerning placental findings presented with a prenatally-identified liver mass. Magnetic resonance imaging (MRI) showed a marked increase in the size of the mass over a three-month period. Prior to surgery, the AFP was elevated and decreased after operative resection. Histopathology confirmed the diagnosis HMH. Rapid growth of HMH is not commonly reported and raises concerns for malignancy. Abnormal placental findings may lead to prematurity, which can affect surgical management. We identified 27 cases of prenatally diagnosed HMH since 1983. The mean gestational age for identification was 29 weeks, with the majority managed by delayed resection. The timing for surgical intervention lacks consensus, but malnutrition and perioperative complications should be considered. High AFP levels with an infantile hepatic mass may indicate a more malignant process but does not exclude HMH. • Consider hepatic mesenchymal hamartomas in a rapidly growing pediatric liver tumor. • Prenatally-identified cases of HMH may be associated with placental abnormalities. • Elevated alpha-fetoprotein levels should not preclude benign liver tumors like HMH. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
24. Rare Benign Tumors of the Liver: Still Rare?
- Author
-
Bertino, Gaetano, Ardiri, Annalisa, Demma, Shirin, GiuseppeCalvagno, Stefano, Toro, Adriana, Basile, Elisa, Campagna, Davide, Ferraro, Giorgia, Frazzetto, Evelise, Proiti, Maria, Malaguarnera, Giulia, Bertino, Nicoletta, Malaguarnera, Mariano, Malaguarnera, Michele, Amaradio, Maria, Pricoco, Gabriele, and Di Carlo, Isidoro
- Abstract
Background: Benign liver tumors are common. They do not spread to other areas of the body, and they usually do not pose a serious health risk. In fact, in most cases, benign liver tumors are not diagnosed because patients are asymptomatic. When they are detected, it's usually because the person has had medical imaging tests, such as an ultrasound (US), computed tomography (CT) scan, or magnetic resonance imaging (MRI), for another condition. Materials and methods: A search of the literature was made using cancer literature and the PubMed, Scopus, and Web of Science (WOS) database for the following keywords: 'hepatic benign tumors', 'hepatic cystic tumors', 'polycystic liver disease', 'liver macroregenerative nodules', 'hepatic mesenchymal hamartoma', 'hepatic angiomyolipoma', 'biliary cystadenoma', and 'nodular regenerative hyperplasia'. Discussion and conclusion: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in some areas of the world; there is an increasing incidence worldwide. Approximately 750,000 new cases are reported per year. More than 75 % of cases occur in the Asia-Pacific region, largely in association with chronic hepatitis B virus (HBV) infection. The incidence of HCC is increasing in the USA and Europe because of the increased incidence of hepatitis C virus (HCV) infection. Unlike the liver HCC, benign tumors are less frequent. However, they represent a chapter always more interesting of liver disease. In fact, a careful differential diagnosis with the forms of malignant tumor is often required in such a way so as to direct the patient to the correct therapy. In conclusion, many of these tumors present with typical features in various imaging studies. On occasions, biopsies are required, and/or surgical removal is needed. In the majority of cases of benign hepatic tumors, no treatment is indicated. The main indication for treatment is the presence of significant clinical symptoms or suspicion of malignancy or fear of malignant transformation. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
25. ALPPS for hepatic mesenchymal hamartoma in an infant
- Author
-
Wei Fan, Long Wang, Zhilin Xu, Chao Li, and Zeng-Hui Hao
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Liver volume ,lcsh:RJ1-570 ,lcsh:Surgery ,lcsh:Pediatrics ,Portal vein ligation ,lcsh:RD1-811 ,030230 surgery ,Abdominal distension ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Hepatic Mesenchymal Hamartoma ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,medicine ,Right hepatic lobe ,Stage (cooking) ,medicine.symptom ,Hepatectomy ,Ligation ,business - Abstract
Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) has been recently introduced as a new procedure to improve the surgical management of large hepatic tumors with future liver remnant (FLR) less than 25% in adults. However, there's rare such case report of infants. We present a case of a 9-month-old infant with huge hepatic mesenchymal hamartoma who underwent ALPPS. The patient initially presented with one week history of abdominal distension and vomit after eating. Computed tomography(CT) showed a right hepatic lobe multilocular mass measuring 10 cm*9 cm*10 cm, occupying Ⅳ,Ⅴ,Ⅵ,Ⅶ,Ⅷ segment. Volumetric assessment of the FLR was 102.31 cm3, which is 22.74% of the estimated total liver volume. With considerably low FLR, we performed ALPPS procedure for the infant. The first stage of the procedure contained the ligation of the right branch of the portal vein and in-situ liver parenchyma split. The second stage entailing right trisectionectomy after 8 days. The success of this application proved that ALPPS is suitable for little infants with giant benign neoplasm. To our knowledge, this is the first successful case of infant's ALPPS. Keywords: Associating liver partition and portal vein ligation for staged hepatectomy, Hepatic tumor, Mesenchymal hamartoma, Infant, Future liver remnant
- Published
- 2018
26. Hepatic Mesenchymal Hamartoma Combined with Infantile Hepatic Hemangioendothelioma in an Infant
- Author
-
Kuang-Hung Hsiao, Lung-Huang Lin, Der-Fang Chen, and Shih-Hung Huang
- Subjects
hepatic hemangioendothelioma ,hepatic mesenchymal hamartoma ,infant ,Medicine (General) ,R5-920 - Abstract
Hepatic mesenchymal hamartoma is a rare benign tumor in children, and infantile hepatic hemangioendothelioma is also a rare liver neoplasm. We report a female newborn with an abdominal mass noted by the regular maternal ultrasound at 32 weeks of gestation. After birth, a liver mass was detected by computed tomography and magnetic resonance cholangiopancreatography. Frequent postprandial vomiting and progressive abdominal distension occurred 4 months later. Three tumor masses were detected this time, and the serum alpha-fetoprotein (AFP) was 6700 ng/mL. Segmental resection was performed initially and complete resection of these tumors and left lobectomy were performed 21 days later. Pathologic examination of these liver masses revealed mesenchymal hamartoma combined with infantile hepatic hemangioendothelioma. After half a year of regular follow-up, the AFP level decreased gradually to 79.5 ng/mL, without evidence of tumor recurrence. [J Formos Med Assoc 2007;106(3 Suppl):S1-S4]
- Published
- 2007
- Full Text
- View/download PDF
27. Occult Androgenetic-Biparental Mosaicism and Sporadic Hepatic Mesenchymal Hamartoma.
- Author
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Lin, Jingxian, Cole, Bonnie L, Qin, Xuan, Zhang, Min, and Kapur, Raj P
- Subjects
MOSAICISM ,HAMARTOMA ,CHILDREN'S hospitals ,HETEROZYGOSITY ,DYSPLASIA - Abstract
The incidence of hepatic mesenchymal hamartoma (HMH) is increased in patients with placental mesenchymal dysplasia (PMD), which appears to be caused by androgenetic-biparental mosaicism (ABM). We hypothesized that occult ABM might underlie cases of HMH with no known history of PMD. Formalin-fixed, paraffin-embedded HMH specimens from 10 such patients and liver specimens from 6 non-HMH controls were identified retrospectively from the surgical pathology records of a pediatric hospital. The relative abundance of maternal and paternal alleles was assessed by quantitative polymerase chain reaction amplification of polymorphic short tandem repeats and single nucleotide polymorphisms located on 15 different chromosomes. Androgenetic-biparental mosaicism was diagnosed in one patient based on global allelic imbalances at all informative loci. In that patient, the greatest imbalances were observed in stroma-rich portions of the hamartoma, with no significant imbalance in histologically normal liver or epithelium-rich portions of the hamartoma. A retrospective, unbiased review of the histology and clinical records from all 10 patients revealed no morphologic or clinical correlates to distinguish the affected patient, except that she had multiple cutaneous hemangiomas, which like HMH, appear to be more common in patients with PMD. Our findings suggest that other patients with apparently sporadic HMH, hemangioma, or other lesions seen more frequently with PMD may harbor occult ABM. Recognition of ABM may be important because its long-term consequences are unknown but may be significant. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
28. PLACENTAL MESENCHYMAL DYSPLASIA ASSOCIATED WITH HEPATIC AND PULMONARY HAMARTOMA.
- Author
-
Tortoledo, Maria, A., Galindo, and C., Ibarrola
- Subjects
- *
DYSPLASIA , *DIFFERENTIAL diagnosis , *HAMARTOMA , *GENETICS , *CELLULAR pathology - Abstract
This report describes a 31-week stillborn female infant with placental mesen-chymal dysplasia (PMD) in association with hepatic mesenchymal hamartoma (HMH) and pulmonary hamartoma. Placental mesenchymal dysplasia was initially misdiagnosed as a partial mole. However, histologically, no trophoblastic proliferation or inclusions were observed. Differential diagnosis of the hepatic mass with similar tumors is discussed. To our knowledge, this is the first case of lung hamartoma reported in a fetus and the first case related to PMD and HMH. A common anomalous development of the mesoderm, a reparative post-injury process and a genetic mechanism, have been proposed to explain their pathogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
29. Late diagnosis of hepatic mesenchymal hamartoma and placental mesenchymal dysplasia.
- Author
-
Gurram, Divya, Sung Joung, Steven Jin, Ryder, Lynette, and Nayyar, Roshini
- Subjects
- *
DYSPLASIA , *MESENCHYMAL stem cells , *NATURAL childbirth , *LABOR (Obstetrics) , *FETAL liver cells - Abstract
Placental mesenchymal dysplasia ( PMD) is a rare condition characterised by placental enlargement, oedematous villi and multiple anechoic cysts. Hepatic mesenchymal hamartoma ( HMH) is a benign proliferation of mesenchymal tissue, commonly seen in infants below the age of 2. We report the case of a 28 years old female who was noted to have a fetus with a well-circumscribed cyst on the liver, suggestive of HMH and a large, thickened placenta, with multiple anechoic cysts, consistent with PMD during the third trimester. There were no other structural abnormalities and at 38 weeks she underwent an induction of labour with normal vaginal delivery of a live female infant. While the aetiology is poorly understood, the increased incidence of HMH with PMD and the morphological similarities of the changes seen in both the placenta and liver, suggests a possible common developmental mechanism. There are only 12 other cases of this concurrent pathology in the literature and only one of these had resulted in a term delivery, and ours is the second one to date. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
30. Long-term follow-up of a multifocal hepatic mesenchymal hamartoma producing a-fetoprotein.
- Author
-
Fretzayas, Andrew, Moustaki, Maria, Kitsiou, Sofia, Nychtari, Georgia, and Alexopoulou, E.
- Subjects
- *
HAMARTOMA , *ALPHA fetoproteins , *TUMORS , *LIVER diseases , *BLOOD proteins , *HEPATECTOMY , *THERAPEUTICS - Abstract
We here present a 6-month-old girl with cystic hepatic mesenchymal hamartoma and elevated a-fetoprotein (aFP). Following hepatectomy of the left lobe and partial right lobectomy, decline of the serum aFP was observed. The child has been well for 20 years and it is one among a few cases with such a long observational period. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
31. Hepatic Mesenchymal Hamartoma: Cytogenetic Analysis of a Case and Review of the Literature.
- Author
-
BABOIU, OANA-EUGENIA, SAAL, HOWARD, and COLLINS, MARGARET
- Subjects
LIVER tumors ,CHROMOSOME abnormalities ,JUVENILE diseases ,ANEUPLOIDY ,PATHOLOGICAL physiology ,GENETICS - Abstract
Hepatic mesenchymal hamartoma (HMH) is a rare benign liver tumor generally occurring in young children. Abnormalities of chromosome 19q13.4 and chromosomal aneuploidy detected by flow cytometry have been reported in HMH. We recently analyzed a HMH in a 14-month-old girl and identified additional novel chromosome abnormalities, including hypodiploidy with deletions of several chromosomes, without rearrangement of 19q13.4 on both routine chromosome analysis and fluorescent in-situ hybridization analysis using subtelomere probes for chromosome 19q. This case underscores the need for chromosome analysis of all HMH and the need to report these changes to better understand the pathophysiology and the entire spectrum of cytogenetics of this uncommon tumor. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
32. 3D simulation assisted resection of giant hepatic mesenchymal hamartoma in children
- Author
-
Xiwei Hao, Xianjun Zhou, Bin Wei, Zhong Jiang, Chengzhan Zhu, Jing Zhao, Dong Qian, Hong Zhang, Gang Zhang, and Ying Wu
- Subjects
Male ,medicine.medical_specialty ,Hamartoma ,medicine.medical_treatment ,3d simulation ,Severity of Illness Index ,Surgical planning ,Resection ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Hepatectomy ,Humans ,Medicine ,Computer Simulation ,Radiation treatment planning ,Retrospective Studies ,Computer-assisted surgery ,business.industry ,Liver Diseases ,Infant ,Computer Science Applications ,Image-guided surgery ,Liver ,Surgery, Computer-Assisted ,Hepatic Mesenchymal Hamartoma ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Surgery ,Radiology ,Tomography, X-Ray Computed ,Family Practice ,business ,Follow-Up Studies - Abstract
To evaluate the usefulness of Hisense Computer Assisted Surgery System (Hisense CAS) in pre-operative surgical planning and intra-operative navigation for resection of pediatric giant hepatic mesenchymal hamartoma (HMH).Five children with HMH underwent hepatectomy in our hospital. Pre-operative abdominal enhanced CT was performed for diagnosis and treatment planning. Using CT DICOM files, three-dimensional reconstruction was performed in three cases for operation planning and intra-operative navigation, with SID carrying out precise liver resection during the operation with Hisense CAS.Two patients underwent right and left lobe hepatectomy, respectively, based only on enhanced CT. In 3 patients, by using the Hisense CAS system, three-dimensional reconstruction of the liver and tumors was successfully completed, and virtual hepatectomy performed successfully according to surgical plans. Hisense CAS could clearly and directly indicate the HMH location and shape, as well as its relationship with the intra-hepatic Glisson system, assisting safe hepatectomy. All five patients recovered well from surgery without any complications, and pathological examinations confirmed that all cases were HMH. No recurrence was observed during the follow-up period of 3 months to 5 years.Hisense CAS system is useful for preoperative planning and intra-operative navigation, assisting safer hepatectomy.
- Published
- 2017
33. Hepatic mesenchymal hamartoma and placental mesenchymal dysplasia: an association ever less rare; a focus on current Knowledge
- Author
-
Roberto Biagiotti, Anna Maria Buccoliero, M. Di Tommaso, and Adalgisa Cordisco
- Subjects
Pathology ,medicine.medical_specialty ,Hepatic Mesenchymal Hamartoma ,business.industry ,medicine ,business ,Placental Mesenchymal Dysplasia - Published
- 2020
34. Recurrent hepatic mesenchymal hamartoma with osseous metaplasia
- Author
-
Nur Rahadiani, Marini Stephanie, and Juan Putra
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Metaplasia ,Hepatology ,business.industry ,Hamartoma ,Liver Diseases ,Bone and Bones ,03 medical and health sciences ,0302 clinical medicine ,Liver ,Hepatic Mesenchymal Hamartoma ,030220 oncology & carcinogenesis ,Medicine ,Humans ,030211 gastroenterology & hepatology ,Osseous metaplasia ,medicine.symptom ,business ,Child ,Liver pathology - Published
- 2018
35. Hepatic mesenchymal hamartoma: The role of radiology in diagnosis and management.
- Author
-
Ninh TP, Dinh TQ, My TT, Hieu BK, Bang LV, and Duc NM
- Abstract
Hepatic mesenchymal hamartoma is an uncommon tumor composed of myxoid mesenchymal tissue with fluid accumulation. Here, we report a case of hepatic mesenchymal hamartoma in a 3-year-old patient who was referred to the hospital with abdominal pain and a slight fever. An abdominal ultrasound suggested a liver abscess; however, computed tomography revealed a mass with both cystic and solid components. Liver biopsy confirmed hepatic mesenchymal hamartoma, and this patient underwent the complete removal of this tumor., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
- Published
- 2021
- Full Text
- View/download PDF
36. Adult Solid Hepatic Mesenchymal Hamartoma Masquerading as Malignancy
- Author
-
Dattaprasanna Kulkarni, Prasad Pande, Chandralekha Tampi, and Gunjan Desai
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,lcsh:R ,Clinical Biochemistry ,lcsh:Medicine ,General Medicine ,Malignancy ,medicine.disease ,Mesodermal masses ,Hepatic Mesenchymal Hamartoma ,Medicine ,business ,Liver cancer ,Hamartoma liver - Abstract
Solid Hepatic Mesenchymal Hamartoma (HMH) rarely occurs in adults. We report two cases of solid adult HMH. A 62-year-old female with right upper abdominal pain on Computed Tomography (CT) scan revealed a well defined heterogeneously enhancing solid mass lesion in segment VII of liver along with non-enhancing central necrotic areas. Percutaneous biopsy and intraoperative frozen section were inconclusive and conventional right hepatectomy was done. Final histopathology was solid HMH. Another 63-year-old female with right upper abdominal pain had cirrhotic liver, choledocholithiases, cholelithiases, mild ascites and a right lobe lesion with calcifications on CT scan. Ultrasound guided biopsy showed fibrocollagenous tissue. She was operated for a right hepatectomy and choledochoduodenostomy. Final histopathology revealed solid HMH. Though solid adult HMH is rare, it should be considered in differential diagnosis of solid/cystic/focal or multifocal liver lesions and surgical resection to negative margins is the treatment of choice.
- Published
- 2017
37. Rare Benign Tumors of the Liver: Still Rare?
- Author
-
Nicoletta Bertino, Gabriele Pricoco, Adriana Toro, Davide Campagna, Evelise Frazzetto, Michele Malaguarnera, Maria Domenica Amaradio, Giulia Malaguarnera, Giorgia Ferraro, Stefano GiuseppeCalvagno, Shirin Demma, Annalisa Ardiri, Elisa Basile, Gaetano Bertino, Mariano Malaguarnera, Maria Proiti, and Isidoro Di Carlo
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Biliary cystadenoma ,Asymptomatic ,Multimodal Imaging ,medicine ,Medical imaging ,Humans ,Invited Reviews ,benign tumors ,hepatic cystic tumors ,polycystic liver disease ,liver macro-regenerative nodules ,hepatic mesenchymal hamartoma ,hepatic angiomyolipoma ,Nodular regenerative hyperplasia ,Hepatic angiomyolipoma ,Health risk ,medicine.diagnostic_test ,Liver macro-regenerative nodules ,business.industry ,Cysts ,Polycystic liver disease ,Liver Diseases ,Ultrasound ,Liver Neoplasms ,Gastroenterology ,Magnetic resonance imaging ,medicine.disease ,Prognosis ,Radiation therapy ,Oncology ,Hepatic cystic tumors ,Hepatic benign tumors ,Radiology ,medicine.symptom ,business ,Hepatic mesenchymal hamartoma - Abstract
Background Benign liver tumors are common. They do not spread to other areas of the body, and they usually do not pose a serious health risk. In fact, in most cases, benign liver tumors are not diagnosed because patients are asymptomatic. When they are detected, it’s usually because the person has had medical imaging tests, such as an ultrasound (US), computed tomography (CT) scan, or magnetic resonance imaging (MRI), for another condition. Materials and methods A search of the literature was made using cancer literature and the PubMed, Scopus, and Web of Science (WOS) database for the following keywords: “hepatic benign tumors”, “hepatic cystic tumors”, “polycystic liver disease”, “liver macroregenerative nodules”, “hepatic mesenchymal hamartoma”, “hepatic angiomyolipoma”, “biliary cystadenoma”, and “nodular regenerative hyperplasia”. Discussion and conclusion Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in some areas of the world; there is an increasing incidence worldwide. Approximately 750,000 new cases are reported per year. More than 75 % of cases occur in the Asia-Pacific region, largely in association with chronic hepatitis B virus (HBV) infection. The incidence of HCC is increasing in the USA and Europe because of the increased incidence of hepatitis C virus (HCV) infection. Unlike the liver HCC, benign tumors are less frequent. However, they represent a chapter always more interesting of liver disease. In fact, a careful differential diagnosis with the forms of malignant tumor is often required in such a way so as to direct the patient to the correct therapy. In conclusion, many of these tumors present with typical features in various imaging studies. On occasions, biopsies are required, and/or surgical removal is needed. In the majority of cases of benign hepatic tumors, no treatment is indicated. The main indication for treatment is the presence of significant clinical symptoms or suspicion of malignancy or fear of malignant transformation.
- Published
- 2014
38. Choledochal cyst rupture with an intrahepatic pseudocyst mimicking hepatic mesenchymal hamartoma in an infant
- Author
-
Seok Joo Han, Hye Min Kim, Myung Joon Kim, Min Yung Chang, and Mi Jung Lee
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Cholangiopancreatography, Magnetic Resonance ,Hamartoma ,Intrahepatic bile ducts ,Peritonitis ,Bile Duct Diseases ,Mesenchymal hamartoma ,Diagnosis, Differential ,Cystic lesion ,Humans ,Medicine ,Biliary peritonitis ,Radiology, Nuclear Medicine and imaging ,Choledochal cysts ,Magnetic resonance cholangiopancreatography ,Rupture, Spontaneous ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Infant ,medicine.disease ,Bile Ducts, Intrahepatic ,Hepatic Mesenchymal Hamartoma ,Choledochal Cyst ,Radiology ,business - Abstract
Spontaneous choledochal cyst rupture and consequent biliary peritonitis are rare in children. Here, we report a unique case of intrahepatic bile duct rupture of choledochal cyst type IV that resulted in loculated biliary peritonitis with an intrahepatic pseudocyst mimicking a hepatic mesenchymal hamartoma in a 3-month-old boy. Magnetic resonance cholangiopancreatography can help differentiate these conditions. Regardless of the location, pseudocysts resulting from biliary peritonitis should be considered in cases of choledochal cysts with adjacent fluid collection or cystic lesions.
- Published
- 2015
39. Late diagnosis of hepatic mesenchymal hamartoma and placental mesenchymal dysplasia
- Author
-
Steven Jin Sung Joung, Lynette Ryder, Divya Gurram, and Roshini Nayyar
- Subjects
Pathology ,medicine.medical_specialty ,Fetus ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,Case Study ,Vaginal delivery ,business.industry ,Mesenchymal stem cell ,medicine.disease ,Placental Mesenchymal Dysplasia ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Hepatic Mesenchymal Hamartoma ,Placenta ,medicine ,Etiology ,Radiology, Nuclear Medicine and imaging ,Cyst ,030212 general & internal medicine ,business - Abstract
Placental mesenchymal dysplasia (PMD) is a rare condition characterised by placental enlargement, oedematous villi and multiple anechoic cysts. Hepatic mesenchymal hamartoma (HMH) is a benign proliferation of mesenchymal tissue, commonly seen in infants below the age of 2. We report the case of a 28 years old female who was noted to have a fetus with a well-circumscribed cyst on the liver, suggestive of HMH and a large, thickened placenta, with multiple anechoic cysts, consistent with PMD during the third trimester. There were no other structural abnormalities and at 38 weeks she underwent an induction of labour with normal vaginal delivery of a live female infant. While the aetiology is poorly understood, the increased incidence of HMH with PMD and the morphological similarities of the changes seen in both the placenta and liver, suggests a possible common developmental mechanism. There are only 12 other cases of this concurrent pathology in the literature and only one of these had resulted in a term delivery, and ours is the second one to date.
- Published
- 2016
40. Hepatic mesenchymal hamartoma and infantile hemangioma: a rare association
- Author
-
Ahmad I. Alomari, Michael G. Caty, Gerald Behr, Steven J. Fishman, Harriet J. Paltiel, and Ann M. Kulungowski
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Pathology ,Hamartoma ,Liver Infantile Hemangioma ,Mesenchymal hamartoma ,Hemangioma ,Infantile hemangioma ,medicine ,Humans ,cardiovascular diseases ,Multiple modalities ,Retrospective Studies ,business.industry ,Liver Neoplasms ,Infant, Newborn ,Infant ,Retrospective cohort study ,General Medicine ,medicine.disease ,eye diseases ,body regions ,Hepatic Mesenchymal Hamartoma ,Pediatrics, Perinatology and Child Health ,Liver Hemangioma ,Female ,Surgery ,sense organs ,Radiology ,business - Abstract
Background/Purpose The association between liver infantile hemangioma and mesenchymal hamartoma is rare. This communication reports the clinical, radiologic, and pathologic features of 3 infants with concurrent liver hemangioma and mesenchymal hamartoma. Methods We conducted a comprehensive search of the database of our Vascular Anomalies Center over the past 12 years (1999-2010) for the keywords mesenchymal hamartoma , liver , and hemangioma in a large cohort of patients with liver hemangioma. Medical records and imaging studies of multiple modalities were reviewed. The search included infants with histopathologically proven liver hemangioma and mesenchymal hamartoma confirmed by the clinical and imaging findings. Results There were 112 children with the diagnosis of liver hemangioma; 3 of them (0.027%) had concurrent mesenchymal hamartoma. Mesenchymal hamartoma predates the appearance of multifocal liver hemangiomas in 1 patient. Conclusions The rare coexistence of liver infantile hemangioma and mesenchymal hamartoma could be a true association.
- Published
- 2012
41. Adult Hepatic Mesenchymal Hamartoma: An Unusual Case
- Author
-
Preeti Bansal, Neeraj Krishna Goyal, and Madhawi Sharma
- Subjects
Pathology ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,Unusual case ,Provisional diagnosis ,business.industry ,lcsh:R ,lcsh:Medicine ,Case Report ,Histogenesis ,medicine.disease ,liver ,Mesenchymal hamartoma ,Left lobectomy ,Lesion ,mesenchymal hamartoma ,Hepatic Mesenchymal Hamartoma ,medicine ,Histopathology ,medicine.symptom ,business ,Liver abscess - Abstract
Mesenchymal hamartoma is a benign hamartomatous lesion with unknown histogenesis. It generally occurs in pediatric population and has been rarely reported in adults. We report an unusual case of a cystic mesenchymal hamartoma of liver in an 81-year-old elderly male. A provisional diagnosis of liver abscess was made and definitive histopathology confirmed the diagnosis. This case has been reported because of its rarity.
- Published
- 2014
42. OP02.02: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report
- Author
-
Jin Hoon Chung, H. Boo, Myung-Sik Kim, You Jung Han, and Youn-Jung Lee
- Subjects
Pathology ,medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,Hepatic Mesenchymal Hamartoma ,business.industry ,medicine ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Presentation (obstetrics) ,business ,Placental Mesenchymal Dysplasia - Published
- 2018
43. Hepatic mesenchymal hamartoma: An uncommon but important paediatric diagnosis.
- Author
-
Gray SC, Pienaar JA, Sofianos Z, Varghese J, and Warnich I
- Abstract
Hepatic mesenchymal hamartoma is a rare hepatic tumour seen in the paediatric population. Although this entity has a variable imaging appearance, it has a favourable prognosis if diagnosed and managed correctly. This case presents the ultrasound and computed tomography findings of an 11-month-old patient who presented with a history of progressive abdominal distension and an elevated alfa fetoprotein level on biochemistry. The case describes how a confident perioperative diagnosis could be made on the basis of characteristic imaging features., Competing Interests: The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article., (© 2020. The Authors.)
- Published
- 2020
- Full Text
- View/download PDF
44. Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review.
- Author
-
Martins-Filho SN and Putra J
- Abstract
This review highlights two rare entities that are predominantly seen in children: hepatic mesenchymal hamartoma (HMH) and undifferentiated embryonal sarcoma of the liver (UESL). HMH is a benign lesion predominantly seen in the first 2 years of life, while UESL is malignant and usually identified in patients between 6 and 10 years of age. UESL may arise in the background of HMH, and the association has been supported by similar chromosomal aberrations (19q13.4). The diagnosis of both lesions is primarily based on histologic evaluation, as the clinical and radiological features are not always typical. The clinicopathologic characteristics, pathogenesis, differential diagnoses and treatment for both lesions are discussed., Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript., (© 2020 Juan Putra.)
- Published
- 2020
- Full Text
- View/download PDF
45. Neonatal Hepatic Mesenchymal Hamartoma Causing Cardiac Failure and Disseminated Intravascular Coagulopathy
- Author
-
Elizabeth Heidi Jerome, J. Susman, Phyllis Wan, Jessica J. Kandel, Dominique Jan, and Elvira Parravicini
- Subjects
Adult ,Hepatic Hemangioma ,medicine.medical_specialty ,Pathology ,Hamartoma ,Hepatic mass ,medicine.medical_treatment ,Diagnostic tools ,Mesenchymal hamartoma ,Pregnancy ,medicine ,Coagulopathy ,Humans ,Embolization ,Heart Failure ,business.industry ,Liver Diseases ,Infant, Newborn ,Obstetrics and Gynecology ,Disseminated Intravascular Coagulation ,medicine.disease ,Hepatic Mesenchymal Hamartoma ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,business - Abstract
Even with advance prenatal diagnostic tools, differentiating among specific types of hepatic masses continues to challenge many physicians. Here, we report a neonate with life-threatening hepatic mass, cardiac failure, and disseminated intravascular coagulopathy, which clinically resembled hepatic hemangioma. A hepatic mesenchymal hamartoma was detected by postmortem pathology.
- Published
- 2009
46. Multicystic hepatic mesenchymal hamartoma of childhood.
- Author
-
Donovan, A., Wolverson, M., deMello, D., Craddock, T., and Silberstein, M.
- Abstract
A case of massive mesenchymal hamartoma of the liver is described in a 13-month-old infant. A complex multicystic mass was demonstrated by ultrasound and computed tomography (CT). The appearances suggested the preoperative diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 1981
- Full Text
- View/download PDF
47. Prenatal Diagnosis of Congenital Mesenchymal Hamartoma of Liver: A Case Report
- Author
-
Muralidhar V. Pai, Sreelakshmi Kodandapani, Kanthilatha V. Pai, and Vijay Kumar
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Fetus ,Pathology ,medicine.medical_specialty ,Unusual case ,business.industry ,Obstetrics and Gynecology ,Case Report ,Prenatal diagnosis ,medicine.disease ,lcsh:Gynecology and obstetrics ,Mesenchymal hamartoma ,Benign tumor ,Hepatic Mesenchymal Hamartoma ,medicine ,Cyst ,business ,lcsh:RG1-991 - Abstract
Hepatic mesenchymal hamartoma is a rare benign tumor. We present an unusual case of a fetal abdominal cyst, later diagnosed histopathologically to be mesenchymal hamartoma of liver. The organ of origin was indeterminate on both prenatal and postnatal ultrasounds. As there are no specific sonological findings, whenever a large multicystic fetal abdominal cyst is seen, mesenchymal hamartoma should be considered as a possibility.
- Published
- 2011
48. Activation of the chromosome 19q microRNA cluster in sporadic and androgenetic-biparental mosaicism-associated hepatic mesenchymal hamartoma
- Author
-
Raj P. Kapur, Kent E. Opheim, Jessica E. Berry, and Karen D. Tsuchiya
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Adolescent ,Hamartoma ,Placenta ,Biology ,Mesenchymal hamartoma ,Pathology and Forensic Medicine ,Pregnancy ,microRNA ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Imprinting (psychology) ,Child ,Chromosome Aberrations ,Mosaicism ,Liver Diseases ,Chromosome ,Infant ,General Medicine ,medicine.disease ,Uniparental disomy ,MicroRNAs ,Hepatic Mesenchymal Hamartoma ,Child, Preschool ,Multigene Family ,Pediatrics, Perinatology and Child Health ,Cancer research ,Female ,Chromosomes, Human, Pair 19 - Abstract
Recurrent genetic alterations found in hepatic mesenchymal hamartoma include either androgenetic-biparental mosaicism or chromosomal rearrangements involving chromosome 19q13.4, in the vicinity of the chromosome 19q microRNA cluster ( C19MC). Abnormal activation of C19MC, which is subject to paternal imprinting and is normally expressed only in placenta, could account for both genetic associations because androgenetic cells carry only paternal chromosomes. In this study, a 4.2-Mb deletion involving the 5′-end of C19MC was detected in a sporadic mesenchymal hamartoma by chromosomal microarray. Fluorescence in situ hybridization studies showed that the deletion localized to mesenchymal cells in the stroma of the hamartoma. Quantitative real-time polymerase chain reaction analysis of this tumor, 9 other sporadic hepatic mesenchymal hamartomas, and 3 hamartomas associated with androgenetic-biparental mosaicism demonstrated C19MC microRNA expression in all but 2 sporadic cases, with no significant expression in control liver. The findings support a pathogenetic model for mesenchymal hamartoma as a consequence of “ectopic” activation of C19MC in hepatic stroma, due to either chromosomal rearrangements or paternal uniparental disomy.
- Published
- 2014
49. New sonographic appearance of hepatic mesenchymal hamartoma in childhood
- Author
-
Despina Savvidou, George Pitsoulakis, K. Kakavakis, Marina Vakaki, Marina Papadaki, and C. Koumanidou
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Mesoderm ,Pathology ,medicine.medical_specialty ,Hamartoma ,Mesenchyme ,Mesenchyma ,Mesenchymal hamartoma ,Benign tumor ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Ultrasonography ,business.industry ,Liver Diseases ,Infant ,medicine.disease ,medicine.anatomical_structure ,Hepatic Mesenchymal Hamartoma ,Child, Preschool ,Female ,business ,Fibrous hamartoma of infancy - Abstract
We present clinical, radiographic, and sonographic findings in 3 children with hepatic mesenchymal hamartoma, a rare benign tumor of childhood. The presence of round hyperechoic parietal nodules within the cystic spaces of the hamartomas is a new sonographic finding.
- Published
- 1999
50. Prenatal diagnosis of hepatic mesenchymal hamartoma
- Author
-
Jan E. Dickinson, John Phillips, and Simon Knowles
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Fetus ,Pathology ,medicine.medical_specialty ,business.industry ,Ultrasound ,Obstetrics and Gynecology ,Prenatal diagnosis ,Third trimester ,medicine.disease ,Lesion ,Hepatic Mesenchymal Hamartoma ,medicine ,Hamartoma ,Fetal Demise ,medicine.symptom ,business ,Genetics (clinical) - Abstract
A case of hepatic mesenchymal hamartoma diagnosed prenatally with ultrasound and confirmed histologically post-delivery is presented. Although histologically benign, this lesion resulted in fetal demise secondary to congestive cardiac failure in the third trimester. The development of non-immune hydrops in association with a fetal hepatic mesenchymal hamartoma is a poor prognostic sign for perinatal survival.
- Published
- 1999
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