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248 results on '"Henzler, Christine"'

2. Extracellular-Vesicle-Based Cancer Panels Diagnose Glioblastomas with High Sensitivity and Specificity.

Author

Mut, Melike, Adiguzel, Zelal, Cakir-Aktas, Canan, Hanalioğlu, Şahin, Gungor-Topcu, Gamze, Kiyga, Ezgi, Isikay, Ilkay, Sarac, Aydan, Soylemezoglu, Figen, Strobel, Thomas, Ampudia-Mesias, Elisabet, Cameron, Charles, Aslan, Tulay, Tekirdas, Eray, Hayran, Mutlu, Oguz, Kader, Henzler, Christine, Saydam, Nurten, and Saydam, Okay

Subjects
biomarkers, extracellular vesicles, glioblastoma
Abstract

Glioblastoma is one of the most devastating neoplasms of the central nervous system. This study focused on the development of serum extracellular vesicle (EV)-based glioblastoma tumor marker panels that can be used in a clinic to diagnose glioblastomas and to monitor tumor burden, progression, and regression in response to treatment. RNA sequencing studies were performed using RNA isolated from serum EVs from both patients (n = 85) and control donors (n = 31). RNA sequencing results for preoperative glioblastoma EVs compared to control EVs revealed 569 differentially expressed genes (DEGs, 2XFC, FDR < 0.05). By using these DEGs, we developed serum-EV-based biomarker panels for the following glioblastomas: wild-type IDH1 (96% sensitivity/80% specificity), MGMT promoter methylation (91% sensitivity/73% specificity), p53 gene mutation (100% sensitivity/89% specificity), and TERT promoter mutation (89% sensitivity/100% specificity). This is the first study showing that serum-EV-based biomarker panels can be used to diagnose glioblastomas with a high sensitivity and specificity.

Published
2023

4. Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, Yang, Rendong, Henzler, Christine M, Ho, Yeung, Passow, Courtney, Auch, Benjamin, Carreira, Suzanne, Rodrigues, Daniel Nava, Bertan, Claudia, Hwang, Tae Hyun, Quigley, David A, Dang, Ha X, Morrissey, Colm, Fraser, Michael, Plymate, Stephen R, Maher, Christopher A, Feng, Felix Y, de Bono, Johann S, and Dehm, Scott M

Subjects
Urologic Diseases, Prostate Cancer, Aging, Biotechnology, Cancer, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Androgen Receptor Antagonists, Benzamides, Biomarkers, Tumor, Cell Line, Tumor, Drug Resistance, Neoplasm, Gene Rearrangement, Humans, Male, Neoplasm Metastasis, Nitriles, Phenylthiohydantoin, Prospective Studies, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Whole Genome Sequencing, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeProstate cancer is the second leading cause of male cancer deaths. Castration-resistant prostate cancer (CRPC) is a lethal stage of the disease that emerges when endocrine therapies are no longer effective at suppressing activity of the androgen receptor (AR) transcription factor. The purpose of this study was to identify genomic mechanisms that contribute to the development and progression of CRPC.Experimental designWe used whole-genome and targeted DNA-sequencing approaches to identify mechanisms underlying CRPC in an aggregate cohort of 272 prostate cancer patients. We analyzed structural rearrangements at the genome-wide level and carried out a detailed structural rearrangement analysis of the AR locus. We used genome engineering to perform experimental modeling of AR gene rearrangements and long-read RNA sequencing to analyze effects on expression of AR and truncated AR variants (AR-V).ResultsAR was among the most frequently rearranged genes in CRPC tumors. AR gene rearrangements promoted expression of diverse AR-V species. AR gene rearrangements occurring in the context of AR amplification correlated with AR overexpression. Cell lines with experimentally derived AR gene rearrangements displayed high expression of tumor-specific AR-Vs and were resistant to endocrine therapies, including the AR antagonist enzalutamide.ConclusionsAR gene rearrangements are an important mechanism of resistance to endocrine therapies in CRPC.

Published
2020

6. Thymic regulatory T cells arise via two distinct developmental programs

Author

Owen, David L, Mahmud, Shawn A, Sjaastad, Louisa E, Williams, Jason B, Spanier, Justin A, Simeonov, Dimitre R, Ruscher, Roland, Huang, Weishan, Proekt, Irina, Miller, Corey N, Hekim, Can, Jeschke, Jonathan C, Aggarwal, Praful, Broeckel, Ulrich, LaRue, Rebecca S, Henzler, Christine M, Alegre, Maria-Luisa, Anderson, Mark S, August, Avery, Marson, Alexander, Zheng, Ye, Williams, Calvin B, and Farrar, Michael A

Subjects
Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Autoimmune Disease, Sexually Transmitted Infections, HIV/AIDS, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Autoantigens, Cell Differentiation, Colitis, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Forkhead Transcription Factors, Freund's Adjuvant, Humans, Immune Tolerance, Interleukin-2 Receptor alpha Subunit, Lymphoid Progenitor Cells, Mice, Mice, Transgenic, Mycobacterium tuberculosis, Myelin-Oligodendrocyte Glycoprotein, Peptide Fragments, Signal Transduction, Specific Pathogen-Free Organisms, T-Lymphocytes, Regulatory, Thymus Gland, Biochemistry and cell biology
Abstract

The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors (CD25+ TregP cells) and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). CD25+ TregP cells showed higher rates of apoptosis and interacted with thymic self antigens with higher affinity than did Foxp3lo TregP cells, and had a T cell antigen receptor repertoire and transcriptome distinct from that of Foxp3lo TregP cells. The development of both CD25+ TregP cells and Foxp3lo TregP cells was controlled by distinct signaling pathways and enhancers. Transcriptomics and histocytometric data suggested that CD25+ TregP cells and Foxp3lo TregP cells arose by coopting negative-selection programs and positive-selection programs, respectively. Treg cells derived from CD25+ TregP cells, but not those derived from Foxp3lo TregP cells, prevented experimental autoimmune encephalitis. Our findings indicate that Treg cells arise through two distinct developmental programs that are both required for a comprehensive Treg cell repertoire capable of establishing immunotolerance.

Published
2019

10. Next generation sequencing for clinical diagnostics: Five year experience of an academic laboratory

Author

Hartman, Paige, Beckman, Kenneth, Silverstein, Kevin, Yohe, Sophia, Schomaker, Matthew, Henzler, Christine, Onsongo, Getiria, Lam, Ham Ching, Munro, Sarah, Daniel, Jerry, Billstein, Bradley, Deshpande, Archana, Hauge, Adam, Mroz, Pawel, Lee, Whiwon, Holle, Jennifer, Wiens, Katie, Karnuth, Kylene, Kemmer, Teresa, Leary, Michaela, Michel, Stephen, Pohlman, Laurie, Thayanithy, Venugopal, Nelson, Andrew, Bower, Matthew, and Thyagarajan, Bharat

Published
2019
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11. Paleocene origin of a streamlined digestive symbiosis in leaf beetles

Author

García-Lozano, Marleny, primary, Henzler, Christine, additional, Porras, Miguel Ángel González, additional, Pons, Inès, additional, Berasategui, Aileen, additional, Lanz, Christa, additional, Budde, Heike, additional, Oguchi, Kohei, additional, Matsuura, Yu, additional, Pauchet, Yannick, additional, Goffredi, Shana, additional, Fukatsu, Takema, additional, Windsor, Donald, additional, and Salem, Hassan, additional

Published
2023
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12. Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Author

Lawrence, Mitchell G., Obinata, Daisuke, Sandhu, Shahneen, Selth, Luke A., Wong, Stephen Q., Porter, Laura H., Lister, Natalie, Pook, David, Pezaro, Carmel J., Goode, David L., Rebello, Richard J., Clark, Ashlee K., Papargiris, Melissa, Van Gramberg, Jenna, Hanson, Adrienne R., Banks, Patricia, Wang, Hong, Niranjan, Birunthi, Keerthikumar, Shivakumar, Hedwards, Shelley, Huglo, Alisee, Yang, Rendong, Henzler, Christine, Li, Yingming, Lopez-Campos, Fernando, Castro, Elena, Toivanen, Roxanne, Azad, Arun, Bolton, Damien, Goad, Jeremy, Grummet, Jeremy, Harewood, Laurence, Kourambas, John, Lawrentschuk, Nathan, Moon, Daniel, Murphy, Declan G., Sengupta, Shomik, Snow, Ross, Thorne, Heather, Mitchell, Catherine, Pedersen, John, Clouston, David, Norden, Sam, Ryan, Andrew, Dehm, Scott M., Tilley, Wayne D., Pearson, Richard B., Hannan, Ross D., Frydenberg, Mark, Furic, Luc, Taylor, Renea A., and Risbridger, Gail P.

Published
2018
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15. Staged miRNA re-regulation patterns during reprogramming.

Author

Henzler, Christine M, Li, Zhonghan, Dang, Jason, Arcila, Mary Luz, Zhou, Hongjun, Liu, Jingya, Chang, Kung-Yen, Bassett, Danielle S, Rana, Tariq M, and Kosik, Kenneth S

Subjects
Cells, Cultured, Fibroblasts, Animals, Mice, Iodide Peroxidase, Intercellular Signaling Peptides and Proteins, Calcium-Binding Proteins, Transcription Factors, MicroRNAs, Gene Expression Regulation, Induced Pluripotent Stem Cells, High-Throughput Nucleotide Sequencing, Cellular Reprogramming, Cells, Cultured, Environmental Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundMiRNAs often operate in feedback loops with transcription factors and represent a key mechanism for fine-tuning gene expression. In transcription factor-induced reprogramming, miRNAs play a critical role; however, detailed analyses of miRNA expression changes during reprogramming at the level of deep sequencing have not been previously reported.ResultsWe use four factor reprogramming to induce pluripotent stem cells from mouse fibroblasts and isolate FACS-sorted Thy1- and SSEA1+ intermediates and Oct4-GFP+ induced pluripotent stem cells (iPSCs). Small RNAs from these cells, and two partial-iPSC lines, another iPSC line, and mouse embryonic stem cells (mES cells) were deep sequenced. A comprehensive resetting of the miRNA profile occurs during reprogramming; however, analysis of miRNA co-expression patterns yields only a few patterns of change. Dlk1-Dio3 region miRNAs dominate the large pool of miRNAs experiencing small but significant fold changes early in reprogramming. Overexpression of Dlk1-Dio3 miRNAs early in reprogramming reduces reprogramming efficiency, suggesting the observed downregulation of these miRNAs may contribute to reprogramming. As reprogramming progresses, fewer miRNAs show changes in expression, but those changes are generally of greater magnitude.ConclusionsThe broad resetting of the miRNA profile during reprogramming that we observe is due to small changes in gene expression in many miRNAs early in the process, and large changes in only a few miRNAs late in reprogramming. This corresponds with a previously observed transition from a stochastic to a more deterministic signal.

Published
2013

18. Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer

Author

Zivanovic, Andrej, primary, Miller, Jeffrey T, additional, Munro, Sarah A, additional, Knutson, Todd P, additional, Li, Yingming, additional, Passow, Courtney N, additional, Simonaitis, Pijus, additional, Lynch, Molly, additional, Oseth, LeAnn, additional, Zhao, Shuang G, additional, Feng, Felix Y, additional, Wikström, Pernilla, additional, Corey, Eva, additional, Morrissey, Colm, additional, Henzler, Christine, additional, Raphael, Benjamin J, additional, and Dehm, Scott M, additional

Published
2023
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21. Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer

Author

Zivanovic, Andrej, Miller, Jeffrey T., Munro, Sarah A., Knutson, Todd P., Li, Yingming, Passow, Courtney N., Simonaitis, Pijus, Lynch, Molly, Oseth, LeAnn, Zhao, Shuang G., Feng, Felix Y., Wikström, Pernilla, Corey, Eva, Morrissey, Colm, Henzler, Christine, Raphael, Benjamin J., Dehm, Scott M., Zivanovic, Andrej, Miller, Jeffrey T., Munro, Sarah A., Knutson, Todd P., Li, Yingming, Passow, Courtney N., Simonaitis, Pijus, Lynch, Molly, Oseth, LeAnn, Zhao, Shuang G., Feng, Felix Y., Wikström, Pernilla, Corey, Eva, Morrissey, Colm, Henzler, Christine, Raphael, Benjamin J., and Dehm, Scott M.

Abstract

Androgen receptor (AR) inhibition is standard of care for advanced prostate cancer (PC). However, efficacy is limited by progression to castration-resistant PC (CRPC), usually due to AR re-activation via mechanisms that include AR amplification and structural rearrangement. These two classes of AR alterations often co-occur in CRPC tumors, but it is unclear whether this reflects intercellular or intracellular heterogeneity of AR. Resolving this is important for developing new therapies and predictive biomarkers. Here, we analyzed 41 CRPC tumors and 6 patient-derived xenografts (PDXs) using linked-read DNA-sequencing, and identified 7 tumors that developed complex, multiply-rearranged AR gene structures in conjunction with very high AR copy number. Analysis of PDX models by optical genome mapping and fluorescence in situ hybridization showed that AR residing on extrachromosomal DNA (ecDNA) was an underlying mechanism, and was associated with elevated levels and diversity of AR expression. This study identifies co-evolution of AR gene copy number and structural complexity via ecDNA as a mechanism associated with endocrine therapy resistance.

Published
2023
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22. Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients

Author

Tarullo, Sarah E, primary, He, Yuyu, additional, Daughters, Claire, additional, Knutson, Todd P, additional, Henzler, Christine M, additional, Price, Matthew A, additional, Shanley, Ryan, additional, Witschen, Patrice, additional, Tolg, Cornelia, additional, Kaspar, Rachael E, additional, Hallstrom, Caroline, additional, Gittsovich, Lyubov, additional, Sulciner, Megan L, additional, Zhang, Xihong, additional, Forster, Colleen L, additional, Lange, Carol A, additional, Shats, Oleg, additional, Desler, Michelle, additional, Cowan, Kenneth H, additional, Yee, Douglas, additional, Schwertfeger, Kathryn L, additional, Turley, Eva A, additional, McCarthy, James B, additional, and Nelson, Andrew C, additional

Published
2023
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23. Supplementary Data 2 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
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25. Supplementary Data 4 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
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26. Data from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
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28. Supplementary Data 3 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
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29. Supplementary Methods, Supplementary References, Supplementary Tables 1-3, Supplementary Figures 1-4 from Androgen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance

Author

Kohli, Manish, primary, Ho, Yeung, primary, Hillman, David W., primary, Van Etten, Jamie L., primary, Henzler, Christine, primary, Yang, Rendong, primary, Sperger, Jamie M., primary, Li, Yingming, primary, Tseng, Elizabeth, primary, Hon, Ting, primary, Clark, Tyson, primary, Tan, Winston, primary, Carlson, Rachel E., primary, Wang, Liguo, primary, Sicotte, Hugues, primary, Thai, Ho, primary, Jimenez, Rafael, primary, Huang, Haojie, primary, Vedell, Peter T., primary, Eckloff, Bruce W., primary, Quevedo, Jorge F., primary, Pitot, Henry C., primary, Costello, Brian A., primary, Jen, Jin, primary, Wieben, Eric D., primary, Silverstein, Kevin A.T., primary, Lang, Joshua M., primary, Wang, Liewei, primary, and Dehm, Scott M., primary

Published
2023
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30. Supplementary Data from Multiomic Analysis of Subtype Evolution and Heterogeneity in High-Grade Serous Ovarian Carcinoma

Author

Geistlinger, Ludwig, primary, Oh, Sehyun, primary, Ramos, Marcel, primary, Schiffer, Lucas, primary, LaRue, Rebecca S., primary, Henzler, Christine M., primary, Munro, Sarah A., primary, Daughters, Claire, primary, Nelson, Andrew C., primary, Winterhoff, Boris J., primary, Chang, Zenas, primary, Talukdar, Shobhana, primary, Shetty, Mihir, primary, Mullany, Sally A., primary, Morgan, Martin, primary, Parmigiani, Giovanni, primary, Birrer, Michael J., primary, Qin, Li-Xuan, primary, Riester, Markus, primary, Starr, Timothy K., primary, and Waldron, Levi, primary

Published
2023
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32. Data from Multiomic Analysis of Subtype Evolution and Heterogeneity in High-Grade Serous Ovarian Carcinoma

Author

Geistlinger, Ludwig, primary, Oh, Sehyun, primary, Ramos, Marcel, primary, Schiffer, Lucas, primary, LaRue, Rebecca S., primary, Henzler, Christine M., primary, Munro, Sarah A., primary, Daughters, Claire, primary, Nelson, Andrew C., primary, Winterhoff, Boris J., primary, Chang, Zenas, primary, Talukdar, Shobhana, primary, Shetty, Mihir, primary, Mullany, Sally A., primary, Morgan, Martin, primary, Parmigiani, Giovanni, primary, Birrer, Michael J., primary, Qin, Li-Xuan, primary, Riester, Markus, primary, Starr, Timothy K., primary, and Waldron, Levi, primary

Published
2023
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33. Supplementary Data from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
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34. Supplementary figures and figure legends from Targeting a Single Alternative Polyadenylation Site Coordinately Blocks Expression of Androgen Receptor mRNA Splice Variants in Prostate Cancer

Author

Van Etten, Jamie L., primary, Nyquist, Michael, primary, Li, Yingming, primary, Yang, Rendong, primary, Ho, Yeung, primary, Johnson, Rachel, primary, Ondigi, Olivia, primary, Voytas, Daniel F., primary, Henzler, Christine, primary, and Dehm, Scott M., primary

Published
2023
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35. Supplementary Data 1 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
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38. Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles

Author

Handler, Hillary P., primary, Duvick, Lisa, additional, Mitchell, Jason S., additional, Cvetanovic, Marija, additional, Reighard, Molly, additional, Soles, Alyssa, additional, Mather, Kathleen B., additional, Rainwater, Orion, additional, Serres, Shannah, additional, Nichols-Meade, Tessa, additional, Coffin, Stephanie L., additional, You, Yun, additional, Ruis, Brian L., additional, O’Callaghan, Brennon, additional, Henzler, Christine, additional, Zoghbi, Huda Y., additional, and Orr, Harry T., additional

Published
2022
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39. The Histone Demethylase HR Suppresses Breast Cancer Development through Enhanced CELF2 Tumor Suppressor Activity

Author

Shen, Yao, primary, Singh, Jasvinder, additional, Sah, Bindeshwar, additional, Chen, Zhongming, additional, Ha, Wootae, additional, Henzler, Christine, additional, Su, Tao, additional, Xie, Lillian, additional, Deng, Yibin, additional, Li, Gen, additional, Guo, Hua, additional, Hibshoosh, Hanina, additional, and Liu, Liang, additional

Published
2022
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42. Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients

Author

Tarullo, Sarah E., primary, He, Yuyu, additional, Daughters, Claire, additional, Knutson, Todd P., additional, Henzler, Christine, additional, Price, Matthew, additional, Shanley, Ryan, additional, Witschen, Patrice, additional, Tolg, Cornelia, additional, Kaspar, Rachael E., additional, Hallstrom, Caroline, additional, Gittsovich, Lyubov, additional, Sulciner, Megan L., additional, Zhang, Xihong, additional, Forester, Colleen, additional, Shats, Oleg, additional, Desler, Michelle M., additional, Cowan, Kenneth, additional, Yee, Douglas, additional, Schwertfeger, Kathryn L., additional, Turley, Eva, additional, McCarthy, James B., additional, and Nelson, Andrew C., additional

Published
2022
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46. Disrupting ATXN1 Nuclear Localization in a Knock-in SCA1 Mouse Model Improves a Spectrum of SCA1-Like Phenotypes and their Brain Region Associated Transcriptomic Profiles

Author

Orr, Harry T., primary, Handler, Hillary P., additional, Duvick, Lisa, additional, Mitchell, Jason, additional, Cvetanovic, Marija, additional, Reighard, Molly, additional, Soles, Alyssa, additional, Rainwater, Orion, additional, Serres, Shannah, additional, Nichols-Meade, Tessa, additional, Coffin, Stephanie L., additional, Yoou, Yun, additional, Ruis, Brian, additional, Ocallaghan, Brennon, additional, Henzler, Christine, additional, and Zoghbi, Huda Y., additional

Published
2021
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48. Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)

Author

Dick, Jenna K, Sangala, Jules A, Krishna, Venkatramana D, Khaimraj, Aaron, Hamel, Lydia, Erickson, Spencer M, Hicks, Dustin, Soigner, Yvette, Covill, Laura E, Johnson, Alexander K, Ehrhardt, Michael J, Ernste, Keenan, Brodin, Petter, Koup, Richard A, Khaitan, Alka, Baehr, Carly, Thielen, Beth K, Henzler, Christine M, Skipper, Caleb, Miller, Jeffrey S, Bryceson, Yenan T, Wu, Jianming, John, Chandy C, Panoskaltsis-Mortari, Angela, Orioles, Alberto, Steiner, Marie E, Cheeran, Maxim C-J, Pravetoni, Marco, and Hart, Geoffrey T

Published
2024
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49. Determining distribution and size of larval pacific geoduck clams (Panopea generosa Gould 1850) in quartermaster harbor (Washington, USA) using a novel sampling approach

Author

Becker, Bonnie J., Behrens, Michael D., Shevalier, Yvonne R.A., Henzler, Christine M., Hoaglund, Elizabeth A., and Lemay, Brenda K.

Subjects
Clams -- Distribution, Home range -- Research, Company distribution practices, Biological sciences, Zoology and wildlife conservation
Abstract

ABSTRACT Realistic species-specific information about larval life history is necessary for effective management of shellfish and parameterization of larval connectivity models. The patchiness of dispersing larvae, and the resources needed [...]

Published
2012
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