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1. Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation

Author

Vyzhga, Y., Wittkowski, H., Hentgen, V., Georgin-Lavialle, S., Theodoropoulou, A., Fuehner, S., Jesenak, M., Frenkel, J., Papadopoulou-Alataki, E., Anton, Jordi, Olivieri, A. Nunzia, Brunner, J., Sanchez, J., Koné-Paut, I., Fingerhutova, S., Pillet, P., Meinzer, U., Khubchandani, R., Jansson, A., Haas, J.-P., Berendes, R., Kallinich, T., Horneff, G., Lilienthal, E., Papa, R., Foell, D., Lainka, E., Caorsi, R., Gattorno, M., and Hofer, M.

Published
2024
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2. The Eurofever Registry for autoinflammatory diseases: results of the first 15 months of enrolment

Author

Touitou I, Woo P, Lachmann H, Dolezalova P, Rose C, Hentgen V, Wouters C, Vesely R, Stojanov S, Simon A, Arostegui J, Kummerle-Deschner J, Ozdogan H, Neven B, Girschick H, Kone-Paut I, Hofer M, De Benedetti F, Ozen S, Frenkel J, Toplak N, Martini A, Ruperto N, and Gattorno M

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published
2011
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9. POS1185 IRON DEFICIENCY IN FAMILIAL MEDITERRANEAN FEVER: A STUDY ON 211 ADULT PATIENTS FROM THE JIR COHORT

Author

DI Cola, I., primary, Savey, L., additional, Delplanque, M., additional, Bourguiba, R., additional, Bartoli, A., additional, Aknouche, Z., additional, Bensalek, F., additional, Koné-Paut, I., additional, Rossi-Semerano, L., additional, Melki, I., additional, Bader-Meunier, B., additional, Neven, B., additional, Quartier, P., additional, Boursier, G., additional, Giurgea, I., additional, Cuisset, L., additional, Grateau, G., additional, Hentgen, V., additional, and Georgin-Lavialle, S., additional

Published
2024
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13. Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation

Author

Arts-assistenten Kinderen, Child Health, Vyzhga, Y., Wittkowski, H., Hentgen, V., Georgin-Lavialle, S., Theodoropoulou, A., Fuehner, S., Jesenak, M., Frenkel, J., Papadopoulou-Alataki, E., Anton, Jordi, Olivieri, A. Nunzia, Brunner, J., Sanchez, J., Koné-Paut, I., Fingerhutova, S., Pillet, P., Meinzer, U., Khubchandani, R., Jansson, A., Haas, J. P., Berendes, R., Kallinich, T., Horneff, G., Lilienthal, E., Papa, R., Foell, D., Lainka, E., Caorsi, R., Gattorno, M., Hofer, M., Arts-assistenten Kinderen, Child Health, Vyzhga, Y., Wittkowski, H., Hentgen, V., Georgin-Lavialle, S., Theodoropoulou, A., Fuehner, S., Jesenak, M., Frenkel, J., Papadopoulou-Alataki, E., Anton, Jordi, Olivieri, A. Nunzia, Brunner, J., Sanchez, J., Koné-Paut, I., Fingerhutova, S., Pillet, P., Meinzer, U., Khubchandani, R., Jansson, A., Haas, J. P., Berendes, R., Kallinich, T., Horneff, G., Lilienthal, E., Papa, R., Foell, D., Lainka, E., Caorsi, R., Gattorno, M., and Hofer, M.

Published
2024

15. Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies

Author

Gocko, X., Lenormand, C., Lemogne, C., Bouiller, K., Gehanno, J.-F., Rabaud, C., Perrot, S., Eldin, C., de Broucker, T., Roblot, F., Toubiana, J., Sellal, F., Vuillemet, F., Sordet, C., Fantin, B., Lina, G., Sobas, C., Jaulhac, B., Figoni, J., Chirouze, C., Hansmann, Y., Hentgen, V., Caumes, E., Dieudonné, M., Picone, O., Bodaghi, B., Gangneux, J.-P., Degeilh, B., Partouche, H., Saunier, A., Sotto, A., Raffetin, A., Monsuez, J.-J., Michel, C., Boulanger, N., Cathebras, P., and Tattevin, P.

Published
2019
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16. Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis

Author

Figoni, J., Chirouze, C., Hansmann, Y., Lemogne, C., Hentgen, V., Saunier, A., Bouiller, K., Gehanno, J.F., Rabaud, C., Perrot, S., Caumes, E., Eldin, C., de Broucker, T., Jaulhac, B., Roblot, F., Toubiana, J., Sellal, F., Vuillemet, F., Sordet, C., Fantin, B., Lina, G., Gocko, X., Dieudonné, M., Picone, O., Bodaghi, B., Gangneux, J.P., Degeilh, B., Partouche, H., Lenormand, C., Sotto, A., Raffetin, A., Monsuez, J.J., Michel, C., Boulanger, N., Cathebras, P., and Tattevin, P.

Published
2019
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17. Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies (II). Biological diagnosis, treatment, persistent symptoms after documented or suspected Lyme borreliosis

Author

Jaulhac, B., Saunier, A., Caumes, E., Bouiller, K., Gehanno, J.F., Rabaud, C., Perrot, S., Eldin, C., de Broucker, T., Roblot, F., Toubiana, J., Sellal, F., Vuillemet, F., Sordet, C., Fantin, B., Lina, G., Sobas, C., Gocko, X., Figoni, J., Chirouze, C., Hansmann, Y., Hentgen, V., Cathebras, P., Dieudonné, M., Picone, O., Bodaghi, B., Gangneux, J.P., Degeilh, B., Partouche, H., Lenormand, C., Sotto, A., Raffetin, A., Monsuez, J.J., Michel, C., Boulanger, N., Lemogne, C., and Tattevin, P.

Published
2019
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21. OP0036 FREQUENCY AND FACTORS ASSOCIATED WITH DIAGNOSTIC DELAY IN EUROPEAN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER: A STUDY ON 960 PATIENTS FROM THE JIR COHORT

Author

Bourguiba, R., primary, Deshayes, S., additional, Amaryan, G., additional, Koné-Paut, I., additional, Belot, A., additional, Sarkisyan, T., additional, Guedri, R., additional, Hofer, M., additional, Pachlopnik Schmid, J., additional, Melki, I., additional, Meinzer, U., additional, Dan, D., additional, Schleinitz, N., additional, Hentgen, V., additional, and Georgin-Lavialle, S., additional

Published
2023
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23. Manifestations cutanées atypiques lors de l’apparition de l’arthrite juvénile idiopathique de forme systémique et difficultés de traitement : une étude rétrospective multicentrique

Author

Eveillard, L.A., primary, Quartier, P., additional, Ouldali, N., additional, Bader-Meunier, B., additional, Bourrat, E., additional, Aeschlimann, F., additional, Ballot, C., additional, Bouric, P., additional, Desdoits, A., additional, Dumaine, C., additional, Galeotti, C., additional, Hentgen, V., additional, Lefevre-Utile, A., additional, Chausset, A., additional, Hubiche, T., additional, Kupfer-Bessaguet, I., additional, Leclerq-Mercier, S., additional, Mallet, S., additional, Melki, I., additional, Merlin, E., additional, Miquel, J., additional, Piram, M., additional, Talmud, D., additional, Garcelon, N., additional, Vinit, C., additional, Welfringer, A., additional, and Meinzer, U., additional

Published
2022
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24. Cutaneous manifestations of monogenic auto-inflammatory diseases: An international cohort study from the Juvenile Inflammatory Rheumatism cohort

Author

Monfort, J.B., primary, Deshayes, S., additional, Dusser, P., additional, Bourguiba, R., additional, Savey, L., additional, Vinit, C., additional, Koné-Paut, I., additional, Amaryan, G., additional, Theodoropoulou, K., additional, Guedri, R., additional, Pachlopnik, J., additional, Belot, A., additional, Melki, I., additional, Perveen Maldar, N., additional, Hentgen, V., additional, Georgin-Lavialle, S., additional, Wouters, C., additional, Woerner, A., additional, Kaiser, D., additional, Berthet, G., additional, Merlin, E., additional, Pillet, P., additional, Richer, O., additional, Barbier, C., additional, Ballot, C., additional, Bolt, I., additional, Wittkowski, H., additional, Rotornaz, K., additional, Jurquet, A.L., additional, Poignant, S., additional, Meinzer, U., additional, Vanoni, F., additional, Dan, D., additional, Lega, J.C., additional, Brunner, J., additional, Aouba, A., additional, Uettwiller, F., additional, Kaplanski, G., additional, Ardois, S., additional, Schleinitz, N., additional, and Dehoorne, J., additional

Published
2022
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25. Manifestations cutanées des maladies auto-inflammatoires monogéniques : étude de cohorte internationale

Author

Monfort, J.B., primary, Deshayes, S., additional, Dusser, P., additional, Bourguiba, R., additional, Savey, L., additional, Vinit, C., additional, Kone-Paut, I., additional, Amaryan, G., additional, Theodoropoulou, K., additional, Guedri, R., additional, Pachlopnik, J., additional, Belot, A., additional, Melki, I., additional, Perveen-Maldar, N., additional, Hentgen, V., additional, and Georgin-Lavialle, S., additional

Published
2022
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31. Cutaneous manifestations of monogenic auto-inflammatory diseases: An international cohort study from the Juvenile Inflammatory Rheumatism cohort

Author

Monfort, J B, Deshayes, S, Dusser, P, Bourguiba, R, Savey, L, Vinit, C, Koné-Paut, I, Amaryan, G, Theodoropoulou, K, Guedri, R, Pachlopnik, Jana, Belot, A, Melki, I, Perveen Maldar, N, Hentgen, V, Georgin-Lavialle, S, University of Zurich, and Monfort, J B

Subjects
2708 Dermatology, 10036 Medical Clinic, 610 Medicine & health
Published
2022
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34. Caractéristiques cliniques de la Covid-19 chez les enfants et adolescents atteints de maladies rhumatismales et inflammatoires : données de la cohorte française RMD COVID-19 de 95 patients

Author

Mammou Mraghni, S., primary, Drumez, E., additional, Aeschlimann, F., additional, Pajot-Audouin, C., additional, Bader-Meunier, B., additional, Carbasse, A., additional, Clet, J., additional, Deslandre, C., additional, Duquesne, A., additional, Dusser, P., additional, Guillaume-Czitrom, S., additional, Hentgen, V., additional, Koné-Paut, I., additional, Melki, I., additional, Quartier, P., additional, Hachulla, E., additional, and Belot, A., additional

Published
2021
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35. O.54 - Rhumatismes à début juvénile (JIRcohorte) : suivi prospectif d’une cohorte de plus de 1800 patients

Author

Hofer, M., Hentgen, V., Bader-Meunier, B., Lavialle, S. Georgin, Guex-Crosier, Y., Rossi-Semerano, L., Scolozzi, P., Woerner, A., Fonjallaz, B., Wouters, C., Carlomagno, R., Cabrera, N., Cannizzaro, E., Schroeder, S., Kaiser, D., Merlin, E., Despert, V., Ballot, C., Poignant, S., Lohse, A., Carbasse, A., Bar, W., Bouayed, K., Freychet, C., Koné-Paut, I., and Belot, A.

Published
2016
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36. The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry

Author

Lachmann, H J, Papa, R, Gerhold, K, Obici, L, Touitou, I, Cantarini, L, Frenkel, J, Anton, J, Kone-Paut, I, Cattalini, M, Bader-Meunier, B, Insalaco, A, Hentgen, V, Merino, R, Modesto, C, Toplak, N, Berendes, R, Ozen, S, Cimaz, R, Jansson, A, Brogan, P A, Hawkins, P N, Ruperto, N, Martini, A, Woo, P, and Gattorno, M

Published
2014
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41. Perception des relations entre les jeunes patients et les médecins lors de la transition de la pédiatrie à la médecine adulte : résultat d’une enquête réalisée auprès de 100 médecins et 104 jeunes

Author

Herasse, M., primary, Romier, M., additional, Hentgen, V., additional, Duquesne, A., additional, Larbre, J.P., additional, Maillard, H., additional, Pha, M., additional, Pillet, P., additional, Reumaux, H., additional, Truchetet, M.E., additional, Belot, A., additional, and Georgin-Lavialle, S., additional

Published
2020
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42. Borréliose de Lyme et autres maladies vectorielles à tiques. Recommandations des sociétés savantes françaises

Author

Gocko, X., Lenormand, C., Lemogne, C., Bouiller, K., Gehanno, J.-F., Rabaud, C., Perrot, S., Eldin, C., De Broucker, T., Roblot, F., Toubiana, J., Sellal, F., Vuillemet, F., Sordet, C., Fantin, B., Lina, G., Sobas, C., JAULHAC, B., Figoni, J., Chirouze, C., Hansmann, Y., Hentgen, V., Caumes, E., Dieudonné, M., Picone, O., Bodaghi, B., Gangneux, J.-P., Degeilh, B., Partouche, H., Saunier, A., Sotto, A., Raffetin, A., Monsuez, J.-J., Michel, C., Boulanger, N., Cathébras, P., Tattevin, P., CHU Rouen, Normandie Université (NU), Université Paris Descartes - Paris 5 (UPD5), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), service de maladies infectieuses CHU J Minjoz Besancon, Hôpital Jean Minjoz, Haut Conseil de la Santé Publique, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Service de neurologie [CH Saint Denis], Centre Hospitalier de Saint-Denis [Ile-de-France], Médecine interne [ Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôpital de Hautepierre [Strasbourg], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Centre National de référence des Staphylocoques, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL), CHU Strasbourg, Service de maladies infectieuses et tropicales, Service de Pédiatrie, Centre Hospitalier de Versailles André Mignot (CHV), Centre Max Weber (CMW), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM), Service de Parasitologie-Mycologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Estación Biológica de Doñana CSIC (SPAIN), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Centre Hospitalier Intercommunal Villeneuve-Saint-Georges (CHIV), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service des maladies infectieuses et réanimation médicale, and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou

Subjects
Borréliose de Lyme, Recommandations, Maladies à tiques, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2019

43. Borréliose de Lyme et autres maladies vectorielles à tiques. Recommandations des sociétés savantes françaises (Argumentaire I) : prévention, épidémiologie, circonstances du diagnostic

Author

Figoni, J, Chirouze, C, Hansmann, Y, Lemogne, C, Hentgen, V, Saunier, A, Bouiller, K, Gehanno, J F, Rabaud, C, Perrot, S, Caumes, E, Eldin, C, de Broucker, T, Jaulhac, B, Roblot, F, Toubiana, J, Sellal, F, Vuillemet, F, Sordet, C, Fantin, B, Lina, G, Gocko, X, Dieudonné, M, Picone, O., Bodaghi, B, Gangneux, Jean-Pierre, Degeilh, B, Partouche, H, Lenormand, C, Sotto, A, Raffetin, A, Monsuez, J J, Michel, C, Boulanger, N, Cathebras, P, Tattevin, P, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Paris-Est Marne-la-Vallée (UPEM), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm - Paris Descartes), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon, Departement de Neurologie (HCL), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Max Weber (CMW), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Strasbourg (UNISTRA), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Pontchaillou [Rennes], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Santé publique France, Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Laboratoire Chrono-environnement (UMR 6249) (LCE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Prévention, Erythema migrans, Neuroborreliosis, Arthritis, [SDV]Life Sciences [q-bio], Borréliose de Lyme, Ticks, Arthrite, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Érythème migrant, France, Tiques, ComputingMilieux_MISCELLANEOUS, Neuroborréliose, Lyme borreliosis
Abstract

International audience

Published
2019

44. Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis: prevention, epidemiology, diagnosis

Author

Figoni, J. (J), Chirouze, C. (C), Hansmann, Y. (Yves), Lemogne, C. (C), Hentgen, V. (V), Saunier, A. (A), Bouiller, K. (K), Gehanno, J. (J) F. (F), Rabaud, C. (C), Perrot, S. (S), Caumes, E. (E), Eldin, C. (C), de Broucker, T. (T), Jaulhac, B. (Benoit), Roblot, F. (F), Toubiana, J. (J), Sellal, F. (Francois), Vuillemet, F. (F), Sordet, C. (Christelle), Fantin, B. (B), Lina, G. (G), Gocko, X. (X), Dieudonné, M. (M), Picone, O. (O), Bodaghi, B. (B), Gangneux, J. (J) P. (P), Degeilh, B. (B), Partouche, H. (H), Lenormand, C. (Cedric), Sotto, A. (A), Raffetin, A. (A), Monsuez, J. (J) J. (J), Michel, C. (C), Boulanger, N. (Nathalie), Cathebras, P. (P), and Tattevin, P. (P)

Subjects
Aucun, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie
Abstract

Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Secondary prevention relies on early detection of ticks after exposure, and mechanical extraction. There is currently no situation in France when prophylactic antibiotics would be recommended. The incidence of Lyme borreliosis in France, estimated through a network of general practitioners (réseau Sentinelles), and nationwide coding system for hospital stays, has not significantly changed between 2009 and 2017, with a mean incidence estimated at 53 cases/100,000 inhabitants/year, leading to 1.3 hospital admission/100,000 inhabitants/year. Other tick-borne diseases are much more seldom in France: tick-borne encephalitis (around 20 cases/year), spotted-fever rickettsiosis (primarily mediterranean spotted fever, around 10 cases/year), tularemia (50–100 cases/year, of which 20% are transmitted by ticks), human granulocytic anaplasmosis (< 10 cases/year), and babesiosis (< 5 cases/year). The main circumstances of diagnosis for Lyme borreliosis are cutaneous manifestations (primarily erythema migrans, much more rarely borrelial lymphocytoma and atrophic chronic acrodermatitis), neurological (< 15% of cases, mostly meningoradiculitis and cranial nerve palsy, especially facial nerve) and rheumatologic (mostly knee monoarthritis, with recurrences). Cardiac and ophtalmologic manifestations are very rarely encountered.

Published
2019

45. The European network for care of children with paediatric rheumatic diseases: care across borders

Author

Dolezalova P, Anton-Lopez J, Avcin T, Beresford MW, Brogan PA, Constantin T, Egert Y, Foeldvari I, Foster HE, Hentgen V, Kone-Paut I, Kuemmerle-Deschner JB, Lahdenne P, Magnusson B, Martini A, McCann L, Minden K, Ozen S, Schoemaker C, Quartier P, Ravelli A, Rumba-Rozenfelde I, Ruperto N, Vastert S, Wouters C, Zulian F, Wulffraat NM, and SHARE Consortium and the Paediatric Rheumatology International Trials Organisati

Subjects
standards of care, paediatric rheumatology, service provision
Abstract

OBJECTIVES: To provide an overview of the paediatric rheumatology (PR) services in Europe, describe current delivery of care and training, set standards for care, identify unmet needs and inform future specialist service provision. METHODS: An online survey was developed and presented to national coordinating centres of the Paediatric Rheumatology International Trials Organisation (PRINTO) (country survey) and to individual PR centres (centre and disease surveys) as a part of the European Union (EU) Single Hub and Access point for paediatric Rheumatology in Europe project. The survey contained components covering the organization of PR care, composition of teams, education, health care and research facilities and assessment of needs. RESULTS: Response rates were 29/35 (83%) for country surveys and 164/288 (57%) for centre surveys. Across the EU, approximately one paediatric rheumatologist is available per million population. In all EU member states there is good access to specialist care and medications, although biologic drug availability is worse in Eastern European countries. PR education is widely available for physicians but is insufficient for allied health professionals. The ability to participate in clinical trials is generally high. Important gaps were identified, including lack of standardized clinical guidelines/recommendations and insufficient adolescent transition management planning. CONCLUSION: This study provides a comprehensive description of current specialist PR service provision across Europe and did not reveal any major differences between EU member states. Rarity, chronicity and complexity of diseases are major challenges to PR care. Future work should facilitate the development, dissemination and implementation of standards of care, treatment and service recommendations to further improve patient-centred health care across Europe.

Published
2019

47. Classification criteria for autoinflammatory recurrent fevers

Author

Gattorno, M., Hofer, M., Federici, S., Vanoni, F., Bovis, F., Aksentijevich, I., Anton, J., Arostegui, J.I., Barron, K., Ben-Cherit, E., Brogan, P.A., Cantarini, L., Ceccherini, I., Benedetti, F. De, Dedeoglu, F., Demirkaya, E., Frenkel, J., Goldbach-Mansky, R., Gul, A., Hentgen, V., Hoffman, H., Kallinich, T., Kone-Paut, I., Kuemmerle-Deschner, J., Lachmann, H.J., Laxer, R.M., Livneh, A., Obici, L., Ozen, S., Rowczenio, D., Russo, R., Shinar, Y., Simon, A., Toplak, N., Touitou, I., Uziel, Y., Gijn, M. van, Foell, D., Garassino, C., Kastner, D., Martini, A., Sormani, M.P., Ruperto, N., Gattorno, M., Hofer, M., Federici, S., Vanoni, F., Bovis, F., Aksentijevich, I., Anton, J., Arostegui, J.I., Barron, K., Ben-Cherit, E., Brogan, P.A., Cantarini, L., Ceccherini, I., Benedetti, F. De, Dedeoglu, F., Demirkaya, E., Frenkel, J., Goldbach-Mansky, R., Gul, A., Hentgen, V., Hoffman, H., Kallinich, T., Kone-Paut, I., Kuemmerle-Deschner, J., Lachmann, H.J., Laxer, R.M., Livneh, A., Obici, L., Ozen, S., Rowczenio, D., Russo, R., Shinar, Y., Simon, A., Toplak, N., Touitou, I., Uziel, Y., Gijn, M. van, Foell, D., Garassino, C., Kastner, D., Martini, A., Sormani, M.P., and Ruperto, N.

Abstract

Contains fulltext : 208780.pdf (publisher's version ) (Closed access), BACKGROUND: Different diagnostic and classification criteria are available for hereditary recurrent fevers (HRF)-familial Mediterranean fever (FMF), tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency (MKD) and cryopyrin-associated periodic syndromes (CAPS)-and for the non-hereditary, periodic fever, aphthosis, pharyngitis and adenitis (PFAPA). We aimed to develop and validate new evidence-based classification criteria for HRF/PFAPA. METHODS: Step 1: selection of clinical, laboratory and genetic candidate variables; step 2: classification of 360 random patients from the Eurofever Registry by a panel of 25 clinicians and 8 geneticists blinded to patients' diagnosis (consensus >/=80%); step 3: statistical analysis for the selection of the best candidate classification criteria; step 4: nominal group technique consensus conference with 33 panellists for the discussion and selection of the final classification criteria; step 5: cross-sectional validation of the novel criteria. RESULTS: The panellists achieved consensus to classify 281 of 360 (78%) patients (32 CAPS, 36 FMF, 56 MKD, 37 PFAPA, 39 TRAPS, 81 undefined recurrent fever). Consensus was reached for two sets of criteria for each HRF, one including genetic and clinical variables, the other with clinical variables only, plus new criteria for PFAPA. The four HRF criteria demonstrated sensitivity of 0.94-1 and specificity of 0.95-1; for PFAPA, criteria sensitivity and specificity were 0.97 and 0.93, respectively. Validation of these criteria in an independent data set of 1018 patients shows a high accuracy (from 0.81 to 0.98). CONCLUSION: Eurofever proposes a novel set of validated classification criteria for HRF and PFAPA with high sensitivity and specificity.

Published
2019

48. MEFV gene analysis in PFAPA

Author

Cazeneuve, C écile, Genevi ève, David, Amselem, Serge, Hentgen, V éronique, Hau, Isabelle, and Reinert, Philippe

Published
2003

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