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5. Thrombininduzierte intravasale Gerinnung am Zwergschwein als Modell zur Schocklunge. Teil II: Veränderung der pulmonalen Kapillarperfusion und der Diffusionskapazität

Author

Stokke, T., Burchardi, H., Hensel, I., Hallecker, P., Jörck, J., Turner, E., Weber, D., Bergmann, H., editor, Brückner, J. B., editor, Gemperle, M., editor, Mayrhofer, O., editor, Frey, R., editor, Henschel, W. F., editor, Peter, K., editor, Weis, Karl-Heinz, editor, and Cunitz, Günther, editor

Published
1980
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7. Thrombininduzierte intravasale Gerinnung am Zwergschwein als Modell zur Schocklunge. Teil I: Veränderung der Atemmechanik und der ventilatorischen Verteilung

Author

Hensel, I., Burchardi, H., Stokke, T., Hallecker, P., Jörck, J., Turner, E., Weber, D., Wencker, K. H., Bergmann, H., editor, Brückner, J. B., editor, Gemperle, M., editor, Mayrhofer, O., editor, Frey, R., editor, Henschel, W. F., editor, Peter, K., editor, Weis, Karl-Heinz, editor, and Cunitz, Günther, editor

Published
1980
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25. Messung von Blutgaspartialdrucken in vivo mit einer Massenspektrometer-Sonde im blutdurchströmten Gefäß - Measurement of Blood-Gas Partial Pressures in vivo with a Mass Spectrometer Probe in a Vessel with Blood-Flow

Author

H. D. Schenk, Bretschneider Hj, Gerhard Hellige, K. W. Beste, and Hensel I

Subjects
Materials science, Biomedical Engineering, Analytical chemistry, chemistry.chemical_element, Blood flow, Partial pressure, Mass spectrometry, Oxygen, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, In vivo, Carbon dioxide, Helium, Blood gas analysis
Published
1976
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27. Blood-gas analysis with a mass spectrometer membrane inlet system

Author

K. W. Beste, H. D. Schenk, Bretschneider Hj, G. Hellige, and Hensel I

Subjects
Pulmonary and Respiratory Medicine, geography, Materials science, geography.geographical_feature_category, 0206 medical engineering, Selected reaction monitoring, Analytical chemistry, Membranes, Artificial, 02 engineering and technology, 010501 environmental sciences, Mass spectrometry, Inlet, 020601 biomedical engineering, 01 natural sciences, Mass Spectrometry, Ion-mobility spectrometry–mass spectrometry, Membrane, Humans, Blood Gas Analysis, Inductively coupled plasma mass spectrometry, 0105 earth and related environmental sciences, Hybrid mass spectrometer, Blood gas analysis
Published
1975

28. Studies of Circulatory and Metabolic Changes during Ketamine Narcosis

Author

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OH, Hensel,I, Braun,U, Kettler,D, Knoll,D, Martel,J, FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OH, Hensel,I, Braun,U, Kettler,D, Knoll,D, and Martel,J

Abstract

Among commonly used anesthetics, ketamine obviously occupies an unusual position. While most anesthetics exert a retarding effect on circulation and metabolism, ketamine clearly has the opposite effect. Figure 1 shows the synopsis of the most important circulatory characteristics after a representative individual test. The injection of ketamine in the animal test causes an increases in heart frequency (HF), HZV (lower curve), coronary blood supply (Vcor) and the myocardial 02 consumption, together with a reduction in coronary venous saturation (upper falling curve). The pressures and the rate of decrease are higher. Eight mongrel dogs weighing between 19 and 27 kg were pre-medicated with 1 mg of scopalamine and 30 minutes later received intravenously on average 20 mg/kg body weight of ketamine which produced in them a condition similar to narcosis. The behavior of PCO2, pH bases excess and the average arterial pressure, heart beat and the central venous pressure during ketamine is discussed. The change in heart beat and the plasma concentration of noradrenaline, adrenaline, glucose and free fatty acids during ketamine narcosis is reported. Oxygen consumption during ketamine narcosis after administration of a muscle relaxant and a morphine derivative is also reportered., Edited trans. of Der Anaesthesist, (Germany, F.R.) v21 n2 p44-49 1972.

Published
1985

29. Messung der Organdurchblutung mit Helium durch massenspektrometrischen Nachweis des Fremdgases

Author

D. Kettler, Hans Becker, Hensel I, G. Hellige, J. Martel, Bretschneider Hj, and D. Behrens

Subjects
03 medical and health sciences, 0302 clinical medicine, 0206 medical engineering, 02 engineering and technology, 030204 cardiovascular system & hematology, 020601 biomedical engineering
Abstract

1948 inaugurierten Kety und Schmidt die N2O-Fremdgasmethode. Seitdem sind verschiedene Arbeitsgruppen bemuht, die Organdurchblutungsmessung mit Fremdgas durch Verwendung anderer Inertgase und durch verfeinerte Mestechniken zu verbessern.

Published
1973
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33. Combination of Tevatron searches for the standard model Higgs boson in the W+W- decay mode

Author

Maxim Perfilov, B. Carls, V. Sorin, P. Lukens, Kevin Lannon, P. Verdier, Guenakh Mitselmakher, Guillelmo Gomez-Ceballos, Marcelo Vogel, V. A. Kuzmin, U. K. Yang, Chris Hays, W. T. Fedorko, Y. A. Yatsunenko, M. Mussini, Y. C. Yang, J. Keung, G. C. Blazey, D. Torretta, A. F. Barfuss, L. Bellantoni, Viatcheslav Stolin, Frank Würthwein, M. Shochet, C. Plager, F. Canelli, V. A. Bezzubov, A. Hocker, P. D. Grannis, Jun Guo, Q. Z. Li, Mark Kruse, Alison Lister, J. P. Fernandez, J. P. Negret, J. Nett, Stefano Giagu, Paul Tipton, G. L. Strycker, C. Mesropian, R. Yamada, D. N. Brown, P. Squillacioti, Kazuhiko Hara, J. Osta, Carlos Avila, L. E. Kirsch, Ricardo Eusebi, J. Galyardt, Alexei Safonov, R. Luna-Garcia, Raimund Ströhmer, V. Simak, D. Krop, Sabine Lammers, Jonas Rademacker, D. Amidei, J. M. Heuser, J. Sekaric, Michael A. Strauss, Jean-Francois Grivaz, K. Devaughan, A. T. Goshaw, P. Padley, Michael Hildreth, P. Skubic, A. Semenov, D. Clark, J. Boudreau, Wendy Taylor, M. Pangilinan, Jason Nielsen, G. Introzzi, B. Casal, Mitchell Wayne, N. Miladinovic, Y. Tu, H. Schellman, J. M. Kohli, K. Potamianos, Z. Gunay-Unalan, Darren Price, A. Sanchez-Hernandez, M. Wiok, Sergo Jindariani, Fedor Prokoshin, P. Jonsson, Thomas Hebbeker, Katsufumi Sato, A. J. Slaughter, Stefan Grünendahl, S. Cihangir, V. Zutshi, Yasuyoshi Nagai, Francesco Crescioli, S. Uzunyan, S. W. Lee, P. Ttito-Guzmán, T. Okusawa, B. Gómez, R. Madrak, Chong-Yu Xu, J. Naganoma, B. Tuchming, P. Wagner, V. Bunichev, Shinhong Kim, J. Budagov, Fabrice Couderc, K. Makhoul, Manfred Paulini, B. Tiller, Dmitri Tsybychev, R. L. McCarthy, Thomas LeCompte, Manuela Campanelli, I. Lazzizzera, Eva Halkiadakis, M. Gold, Tetsuo Arisawa, C. Neu, Amnon Harel, W. M. Lee, K. Kondo, Mary Beth Adams, D. Whiteson, I. Shreyber, K. Yamamoto, Malte Renz, Andrew Askew, R. L. Lander, G. De Lorenzo, A. Savoy-Navarro, Allan G Clark, Roger Moore, D. O. Litvintsev, S. Söldner-Rembold, A. Anastassov, G. Giurgiu, L. Sartori, Sooran Kim, O. Poukhov, A. Jonckheere, H. E. Fisk, P. Lebrun, M. N. Mondragon, I. Hall, A. Lobodenko, Wolfgang Wagner, Liang Li, J. C. Yun, J. Lueck, Stephen Wimpenny, S. Carrillo, J. Backusmayes, Martin Grunewald, Nicola D'Ascenzo, J. A. Appel, P. H. Beauchemin, M. Heck, D. Beecher, Peter McIntyre, G. Pauletta, M. Martínez, J. Patrick, E. Strauss, Guennadi Borissov, M. Jones, C. Pagliarone, D. Menezes, Intae Yu, Oliver Stelzer-Chilton, Th Muller, D. W. Jang, R. Van Kooten, B. Y. Han, I. Heredia-De La Cruz, Michael L. Norman, Yongsun Kim, Lev Dudko, Milos Lokajicek, D. Karmanov, M. M. Deninno, Markus Wobisch, R. Magaña-Villalba, S. W. Cho, G. Obrant, B. Whitehouse, S. Y. Jun, Julia Thom, W. C. Fisher, Adrian Buzatu, V. Boisvert, Daria Zieminska, Suneel Dutt, J. E. Kim, Aran Garcia-Bellido, M. D. Corcoran, S. Cabrera, D. E. Pellett, M. Binkley, R. D. Schamberger, M. Corbo, Y. C. Chen, F. Guo, A. J. Martin, C. Vellidis, Darien Wood, Y. Shon, D. K. Cho, T. R. Wyatt, E. Brubaker, Shabnam Jabeen, S. De Cecco, A. Dubey, G. Grenier, Hwi Dong Yoo, Zdenek Hubacek, L. Santi, A. Alton, Meng Wang, Neeti Parashar, L. Pondrom, E. Wicklund, Christoph Paus, C. P. Buszello, S. Hou, A. Das, M. Sosebee, A. Manousakis-Katsikakis, Emily Nurse, M. Merkin, L. Han, Giorgio Chiarelli, A. Rahaman, J. Huston, J. D. Lewis, Yuehong Xie, T. Scanlon, S. Kermiche, W. H. Chung, M. Rominsky, L. Brigliadori, V. M. Abazov, D. Buchholz, I. Ripp-Baudot, R. McNulty, M. Hare, M. Tecchio, A. Gessler, Helio Nogima, I. Razumov, S. Blessing, M. Zielinski, V. Rusu, A. Elagin, Vyacheslav Krutelyov, G. S. Muanza, Jay Dittmann, W. Ashmanskas, D. Hirschbuehl, H. C. Fang, Frederic Deliot, Michele Gallinaro, G. Savage, Peter Wittich, A. Napier, A. Meyer, Scott Snyder, J. Hays, S. Tokar, Suman Bala Beri, C.S. Johnson, G. Sajot, V. Hynek, Robert Hirosky, Alberto Annovi, P. Murat, Y. Hu, D. J. Cox, A. Di Canto, V. Khotilovich, Y. Seiya, O. Atramentov, Elizaveta Shabalina, M. Lancaster, G. Alkhazov, Y. Zheng, Jian Tang, L. Oakes, A. Gresele, Y. N. Kharzheev, A. Varganov, Sudhir Malik, E. G. Zverev, M. Vidal, Ia Iashvili, G. Manca, P. Roy, Raymond Brock, Robin Erbacher, M. Datta, R. Beuselinck, C. Cuenca Almenar, Javier Cuevas, Jean-Arcady Meyer, J. Mülmenstädt, D. V. Bandurin, S. Greder, Y. W. Liu, Iain Alexander Bertram, Virgil E Barnes, M. Padilla, L. Bagby, M. S. Rangel, Jahred Adelman, Jane Nachtman, Graham Wilson, Sergio F Novaes, S. Hossain, B. Jayatilaka, Kyung-Suk Cho, R. E. Hughes, P. Rich, T. Rodriguez, D. Gillberg, H. Wolfe, B. Sanghi, Suyong Choi, J. Parsons, G. Velev, J. M. Hauptman, Cecilia Elena Gerber, V. M. Podstavkov, G. Chlachidze, Michael Rijssenbeek, S. Zelitch, Jeannine Wagner-Kuhr, M. A. Strang, Brajesh C Choudhary, D. Lucchesi, Bernd Stelzer, S. Tkaczyk, F. Vázquez, P. Svoisky, C. Zeitnitz, J. Yamaoka, Arnulf Quadt, Petar Maksimovic, A. Juste, E. De La Cruz-Burelo, A. Attal, E. Pueschel, T. Wright, S. Grinstein, Todd Adams, K. M. Chan, A. S. Ito, A. Melnitchouk, T. Aaltonen, J. Antos, Thorsten Chwalek, Elemer Nagy, C. J. Lin, W. M. Van Leeuwen, M. Fortner, Sarah Catherine Eno, Horst Severini, Tiehui Liu, Rodolfo Carosi, A. Barbaro-Galtieri, R. G. Feild, J. S. Suh, K. Osterberg, D. Mietlicki, S. Richter, Michal Kreps, T. Nunnemann, B. Baldin, Corrinne Mills, G. P. Yeh, C. S. Moon, M. J. Kim, S. J. Park, A. Menzione, M. E. Convery, E. Palencia, J. C. Cully, Aron Soha, M. Cordelli, G. Busetto, Brian L Winer, G. Ginther, G. Bauer, G. Golovanov, M. J. Morello, F. D. Snider, J. Y. Han, N. Giokaris, Junjie Zhu, S. Wolbers, V. V. Tokmenin, L. S. Vertogradov, R. J. Miller, J. Martínez-Ortega, M. Weinberger, Bjoern Penning, G. Facini, M. Kurata, Andrea Castro, G. D. Alexeev, Flera Rizatdinova, M. Milnik, U. Husemann, B. Álvarez González, V. N. Evdokimov, A. Bridgeman, K. Sliwa, S. Klimenko, Evelyn Thomson, C. Deluca, Fabrizio Scuri, D. Wicke, Dennis Stephen Mackin, Andrew Brandt, Kirti Ranjan, Jianming Qian, J. L. Gimmell, V. V. Lipaev, J. Lellouch, H. A. Neal, Ivan-Kresimir Furic, Y. D. Oh, D. Bauer, M. C. Cousinou, V. A. Giakoumopoulou, Carsten Hensel, A. Mukherjee, C. Belanger-Champagne, B. S. Acharya, Nicola Turini, J. Pursley, H. Nilsen, R. G. Wagner, B. Spurlock, G. Piacentino, M. Buehler, A. T. Laasanen, Zeno Dixon Greenwood, Y. Arnoud, Richard B. Lipton, D. W. Gerdes, Pedro G Mercadante, Ph Gris, T. Kuhr, P. Houben, M. H. Kirby, H. Miyake, F. Happacher, Kristian Harder, Dario Bisello, G. Gutierrez, M. D'Errico, Joe Kroll, B. C.K. Casey, X. Wu, T. A. Schwarz, A. Bhatti, P. A. Kasper, Hugh Williams, M. P. Sanders, Ignacio Redondo, Hyun-Chul Kim, Yurii Maravin, Vladimir Gavrilov, A. Aurisano, Teresa Rodrigo, D. Boline, K. Chung, Peter Love, Pushpalatha C Bhat, W. Geng, N. Ranjan, R. Jesik, S. Carron, L. Demortier, S. Dube, S. H. Oh, M. A. Schmidt, Mark Richard James Williams, R. Bernhard, W. E. Cooper, P. N. Dong, D. Khatidze, Giovanni Bellettini, M. Rossi, J. Slaunwhite, D. Cutts, J. T. Linnemann, David T. Johnston, Gordon Watts, Daniela Bortoletto, O. Mundal, K. Yip, P. E. Karchin, P. Haefner, Roman Lysak, M. Iori, C. Bromberg, Duncan Carlsmith, K. A. Johns, Anna Goussiou, Elisabetta Pianori, A. V. Kotwal, Gregorio Bernardi, Andrea Bocci, D. Denisov, X. Zhang, A. Scribano, D. Onoprienko, T. J. Phillips, A. A. Paramanov, K. Ebina, G. Otero y Garzon, M. Trovato, M. Cavalli-Sforza, W. M. Yao, Aaron Dominguez, Jochen Jens Heinrich, W. Geist, Tiefu Zhao, S. Budd, G. A. Thompson, Je Jung, S. W. Youn, P. Polozov, Koji Nakamura, Arnaud Duperrin, S. Neubauer, S. Y. Tsai, Sharon Hagopian, S. Torre, S. Amerio, S. Zucchelli, A. K.A. Maciel, W. Johnson, K. T. Pitts, A. Simonenko, V. Sirotenko, S. Wilbur, J. K. Kraus, J. Weinelt, Greg Landsberg, I. Suslov, K. Herner, N. Khalatyan, S. Yacoob, A. Schmidt, B. Hoeneisen, Lee Sawyer, Maria Agnese Ciocci, A. Mitra, Michael Schmitt, N. Kimura, Hal Evans, Thomas Ferbel, M. Prewitt, Cristina Galea, M. Hartz, T. Wakisaka, Lars Sonnenschein, Zhanqiang Liu, M. Cooke, Tommaso Dorigo, S. Hewamanage, Sinead Farrington, M. P. Schmidt, P. L.M. Podesta-Lerma, D. H. Kim, V. Kaushik, J. F. Bartlett, J. Lys, Stephan Lammel, Lucio Cerrito, R. E. Blair, Jong-Sung Yu, F. Rimondi, Pavol Bartos, N. Ershaidat, E. E. Boos, E. E. Schmidt, Marco Verzocchi, Theodoros Christoudias, S. Lami, Emanuela Barberis, Avraham Yagil, Dean Hidas, Heriberto Castilla-Valdez, J. Morlock, S. Seidel, R. Unalan, L. Stutte, A. Canepa, C. Ferrazza, C. P. Marino, G. Flanagan, A. N. Sisakyan, E. Rogers, P. Totaro, R. Nayyar, Robert Kehoe, Maxwell Chertok, A. Patwa, W. Badgett, J. Clutter, Md. Naimuddin, V. Papadimitriou, M. Kirsch, A.S. Dyshkant, D. Smirnov, George Alverson, K. Tollefson, E. J. Jeon, A. Sukhanov, R. Vilar, N. Krumnack, P. K. Teng, K. S. McFarland, Federico Sforza, Mark Owen, S. Somalwar, Deepak Kar, R. Piegaia, V. V. Glagolev, MarioPaolo Giordani, S. J. De Jong, K. Soustruznik, Ashok Kumar, E. Carrera, I. Bizjak, J. Conway, E. Lee, M. Stanitzki, A. Papaikonomou, M. E. Mattson, M. Arov, Andre Sopczak, G. Hesketh, B. Brau, D. Hedin, Brad Abbott, P. Catastini, T. Tomura, A. Evdokimov, S. Pagan Griso, Robert Snihur, Marcia Begalli, Ulysses Grundler, C. I. Ciobanu, R. L. Wagner, Jiri Kvita, D. Gerbaudo, D. Lam, S. Z. Shalhout, Victoria Jane Martin, R. Martínez-Ballarín, Thomas Peiffer, Alexander Grohsjean, Phillip Gutierrez, Pierre Petroff, A. Golossanov, Shih-Fu Chang, Rainer Wallny, M. Demarteau, Andreas Warburton, Satoru Uozumi, U. Bassler, Andrew Beretvas, R. F. Harr, M. Mathis, Meenakshi Narain, A. Pronko, Arie Bodek, S. Moed, P. J. Van Den Berg, Lev Uvarov, Marc Besancon, D. Benjamin, K. Goulianos, J. Snow, M. Abolins, S. Rolli, Elliott Cheu, T. Schliephake, A. Taffard, Victor Daniel Elvira, Marvin Johnson, K. Peters, Sung Keun Park, Massimo Casarsa, Sergey Burdin, S. Robinson, J. Deng, Gregory R Snow, A. A. Shchukin, P. Movilla Fernandez, M. Shimojima, J. P. Chou, Heimo Saarikko, A. Sedov, M. A. Carrasco-Lizarraga, M. Feindt, M. Eads, Y. Takeuchi, Regina Demina, J. Strologas, C. Calancha, B. Di Ruzza, P. Sinervo, P. Schlabach, S. P. Denisov, V. Parihar, Frank Fiedler, A. L. Lyon, Philip Baringer, F. Garberson, H. W. Kim, N. K. Mondal, Mauro Dell'Orso, Tulika Bose, S. Pashapour, A. Apresyan, E. Kajfasz, Song-Ming Wang, A. V. Kozelov, Samuel Calvet, H. T. Diehl, T. A. Bolton, P. Neustroev, V. Saveliev, F. Azfar, R. Culbertson, C. Haber, O. Norniella, V. V. Shary, A. Boehnlein, M. Lindgren, J. Piper, S. Banerjee, E. Vataga, Dorothee Schaile, Michael Mulhearn, R. St. Denis, J. R. Smith, G. B. Yu, J. Ellison, W. Ketchum, D. Hare, G. Williams, D. Edmunds, Igor Volobouev, Jeroen Hegeman, J. Linacre, T. Moulik, P. de Barbaro, Avto Kharchilava, C. A. Cox, Fumihiko Ukegawa, Sa. Jain, A. Penzo, S. Fuess, K. K. Joo, T. Kurca, Marc Weber, B. Parks, James Russ, Kohei Yorita, T. Hoang, Franco Bedeschi, R. Otec, D. Glenzinski, Alexander Khanov, Jonas Strandberg, P. B. Renton, J. Orduna, S. S. Yu, Tomoko Yoshida, A. B. Wicklund, D. Jamin, Grigory Safronov, S. Chevalier-Théry, J. Thome, S. Chakrabarti, V. Cavaliere, D. Waters, M. Hohlfeld, P. N. Ratoff, D. Toback, Y. Peters, P. Vint, Zhenyu Ye, Maksym Titov, Yuri Gershtein, N. P. Kulkarni, Y. Zeng, P. Rubinov, Daniel Duggan, Ernest Aguilo, Tara Shears, Hua-Lei Yin, A. V. Popov, W. C. Wester, M. Campbell, D. Stentz, A. Loginov, S. Desai, T. Dorland, D. Dagenhart, M. Jaffré, Gustaaf Brooijmans, M. Rescigno, L. S. Ancu, Petr Vokac, Joseph Haley, J. Warchol, P. Lujan, P. Garosi, Christophe Royon, V. Ramakrishnan, Alexander Leflat, J. Asaadi, Y. S. Chung, E. Camacho-Pérez, C. Wolfe, P. Barria, E. James, B. Calpas, L. Lovas, Reinhard Schwienhorst, S. Behari, Luca Scodellaro, H. D. Wahl, Alexander Kupco, F. Badaud, K. L. Byrum, P. Giromini, Andrew White, Gilvan Alves, L. Sexton-Kennedy, R. Forrest, I. Katsanos, Anna Zanetti, G. Compostella, Maxim Goncharov, N. Huske, N. Parua, D. Vilanova, Randy Ruchti, Joe Incandela, L. Nodulman, J. N. Bellinger, M. D'onofrio, T. Miao, P. Mättig, X. B. Bu, D. Chokheli, R. Kephart, K. Gibson, M. M. Meijer, L. Ristori, N. S. Lockyer, Roberto Rossin, A. Boveia, Aidan Robson, Kevin Burkett, T. Yasuda, R. Illingworth, N. Moggi, D. Errede, S. Beale, Chuan-Ming Liu, G. Punzi, John Hobbs, Yuji Enari, Y. Kato, L. Zivkovic, J. Guimaraes Da Costa, J. Barreto, D. Tonelli, Alexey Ferapontov, M. Wetstein, I. V. Gorelov, H. S. Budd, M. A. Houlden, Andrew Mehta, Jacobo Konigsberg, L. Duflot, J. K. Lim, Stefano Camarda, Frank Chlebana, F. Ptohos, B. Åsman, L. Pinera, A. P. Heinson, S. Malde, M. A. Pleier, P. Renkel, P. Mehtala, M. Giunta, A. Artikov, S. Schlobohm, H. Greenlee, D. M. Strom, Matthew Herndon, E. Lipeles, M. K. Jha, A. Bross, Christopher George Tully, M. Hussein, Benjamin Kilminster, Serban Protopopescu, Barry Blumenfeld, M. Aoki, Andy Haas, G. Weber, D. Chakraborty, J. S. Lee, Don Lincoln, Erich Varnes, S. Shiraishi, S. Kwang, M. Hurwitz, S. R. Hahn, M. Vesterinen, N. Osman, A. Deisher, T. R. Junk, Patrick Slattery, A. Chandra, J. Yoh, D. A. Stoyanova, C. L. McGivern, Gervasio Gomez, Michael Begel, Andrey Korytov, Eduardo De Moraes Gregores, Luiz Mundim, R. Takashima, T. H. Burnett, Amitabh Lath, Anna Sfyrla, Paola Giannetti, B. A. Barnett, Giorgio Apollinari, J. A. Benitez, Teruki Kamon, P. Mazzanti, Craig Blocker, Ulrich Heintz, D. Cauz, Kaori Maeshima, P. K. Mal, H. S. Lee, Frank Filthaut, Paolo Mastrandrea, M. Diesburg, P. Wilson, J. E. Garcia, A. Tanasijczuk, T. Davies, C. S. Hill, Sandra Leone, S. Uvarov, B. Quinn, W. K. Sakumoto, C. Schwanenberger, Alice Bean, C. Grosso-Pilcher, I. Oksuzian, N. Goldschmidt, Volker Buescher, Peter Bussey, T. Gadfort, Maria Elena Pol, Kai Yi, C. M. Ginsburg, R. Roser, Ivan Vila, P. F. Shepard, B. Rutherford, Alexander Ivanov, N. Van Remortel, S. C. Hsu, Reisaburo Tanaka, Guido Volpi, Nikos Varelas, O. González, Bing Zhou, Luis Mendoza, R. K. Shivpuri, S. Donati, Kenichi Hatakeyama, M. Franklin, D. R. Claes, Gavin Davies, Philippe Calfayan, Itsuo Nakano, Harald Fox, S. M. Lietti, Y. Scheglov, J. C. Freeman, Kaushik De, A. Ruiz, Giuseppe Latino, Alan Garfinkel, Jan Stark, Fabrizio Margaroli, S. Errede, Maiko Takahashi, Henry Lubatti, J. Cammin, I. A. Vasilyev, Vipin Bhatnagar, A. Cerri, R. Partridge, Markus Frank, P. M. Tuts, D. MacQueen, H. Gerberich, Kenneth Bloom, V. L. Malyshev, Mark Neubauer, R. Orava, G. Lungu, R. D. Field, D. J. Kong, W. C. Yang, Department of Physics, Helsinki Institute of Physics, CDF Collaboration, D0 Collaboration, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CDF, D0, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universidad de Cantabria, T. 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PHILLIPS, G. PIACENTINO, E. PIANORI, R. PIEGAIA, L. PINERA, J. PIPER, K. PITTS, C. PLAGER, M.-A. PLEIER, P. L. M. PODESTA-LERMA, V. M. PODSTAVKOV, M.-E. POL, P. POLOZOV, L. PONDROM, A. V. POPOV, K. POTAMIANOS, O. POUKHOV, M. PREWITT, D. PRICE, F. PROKOSHIN,U, A. PRONKO, S. PROTOPOPESCU, F. PTOHOS, E. PUESCHEL, G. PUNZI, J. PURSLEY, J. QIAN, A. QUADT, B. QUINN, J. RADEMACKER,§, A. RAHAMAN, V. RAMAKRISHNAN, M. S. RANGEL, K. RANJAN, N. RANJAN, P. N. RATOFF, I. RAZUMOV, I. REDONDO, P. RENKEL, P. RENTON, M. RENZ, M. RESCIGNO, P. RICH, S. RICHTER, M. RIJSSENBEEK, F. RIMONDI, I. RIPP-BAUDOT, L. RISTORIA, F. RIZATDINOVA, S. ROBINSON, A. ROBSON, T. RODRIGO, T. RODRIGUEZ, E. ROGERS, S. ROLLI, M. ROMINSKY, R. ROSER, M. ROSSIA, R. ROSSIN, P. ROY, C. ROYON, P. RUBINOV, R. RUCHTI, A. RUIZ, J. RUSS, V. RUSU, B. RUTHERFORD, H. SAARIKKO, A. SAFONOV, G. SAFRONOV, G. SAJOT, W. K. SAKUMOTO, A. SÁNCHEZ-HERNÁNDEZ, M. P. SANDERS, B. SANGHI, L. SANTI, L. SARTORIA, K. SATO, G. SAVAGE, V. SAVELIEV, A. SAVOY-NAVARRO, L. SAWYER, T. SCANLON, D. SCHAILE, R. D. SCHAMBERGER, Y. SCHEGLOV, H. SCHELLMAN, P. SCHLABACH, T. SCHLIEPHAKE, S. SCHLOBOHM, A. SCHMIDT, E. E. SCHMIDT, M. A. SCHMIDT, M. P. SCHMIDT, M. SCHMITT, C. SCHWANENBERGER, T. SCHWARZ, R. SCHWIENHORST, L. SCODELLARO, A. SCRIBANO, F. SCURIA, A. SEDOV, S. SEIDEL, Y. SEIYA, J. SEKARIC, A. SEMENOV, H. SEVERINI, L. SEXTON-KENNEDY, F. SFORZA, A. SFYRLA, E. SHABALINA, S. Z. SHALHOUT, V. SHARY, A. A. SHCHUKIN, T. SHEARS, P. F. SHEPARD, M. SHIMOJIMA,O, S. SHIRAISHI, R. K. SHIVPURI, M. SHOCHET, Y. SHON, I. SHREYBER, V. SIMAK, A. SIMONENKO, P. SINERVO, V. SIROTENKO, A. SISAKYAN, P. SKUBIC, P. SLATTERY, A. J. SLAUGHTER, J. SLAUNWHITE, K. SLIWA, D. SMIRNOV, J. R. SMITH, F. D. SNIDER, R. SNIHUR, G. R. SNOW, J. SNOW, S. SNYDER, A. SOHA, S. SÖLDNER-REMBOLD, S. SOMALWAR, L. SONNENSCHEIN, A. SOPCZAK, V. SORIN, M. SOSEBEE, K. SOUSTRUZNIK, B. SPURLOCK, P. SQUILLACIOTIC,A, M. STANITZKI, J. STARK, R. ST. DENIS, B. STELZER, O. STELZER-CHILTON, D. STENTZ, V. STOLIN, D. A. STOYANOVA, J. STRANDBERG, M. A. STRANG, E. STRAUSS, M. STRAUSS, R. STRÖHMER, J. STROLOGAS, D. STROM, G. L. STRYCKER, L. STUTTE, J. S. SUH, A. SUKHANOV, I. SUSLOV, P. SVOISKY, A. TAFFARD, M. TAKAHASHI, R. TAKASHIMA, Y. TAKEUCHI, R. TANAKA, A. TANASIJCZUK, J. TANG, W. TAYLOR, M. TECCHIO, P. K. TENG, J. THOM, J. THOME, G. A. THOMPSON, E. THOMSON, B. TILLER, P. TIPTON, M. TITOV, S. TKACZYK, D. TOBACK, S. TOKAR, V. V. TOKMENIN, K. TOLLEFSON, T. TOMURA, D. TONELLI, S. TORRE, D. TORRETTA, P. TOTARO, M. TROVATO, S.-Y. TSAI, D. TSYBYCHEV, P. TTITO-GUZMÁN, B. TUCHMING, Y. TU, C. TULLY, N. TURINI, P. M. TUTS, F. UKEGAWA, R. UNALAN, S. UOZUMI, L. UVAROV, S. UVAROV, S. UZUNYAN, P. J. VAN DEN BERG, R. VAN KOOTEN, W. M. VAN LEEUWEN, N. VAN REMORTEL, N. VARELAS, A. VARGANOV, E. W. VARNES, I. A. VASILYEV, E. VATAGAD,A, F. VÁZQUEZ,H, G. VELEV, C. VELLIDIS, P. VERDIER, L. S. VERTOGRADOV, M. VERZOCCHI, M. VESTERINEN, M. VIDAL, I. VILA, D. VILANOVA, R. VILAR, P. VINT, M. VOGEL, P. VOKAC, I. VOLOBOUEV,S, G. VOLPI, P. WAGNER, R. G. WAGNER, R. L. WAGNER, W. WAGNER,W, J. WAGNER-KUHR, H. D. WAHL, T. WAKISAKA, R. WALLNY, M. H. L. S. WANG, S. M. WANG, A. WARBURTON, J. WARCHOL, D. WATERS, G. WATTS, M. WAYNE, G. WEBER, M. WEBER, M. WEINBERGER, J. WEINELT, W. C. WESTER, III, M. WETSTEIN, A. WHITE, B. WHITEHOUSE, D. WHITESON, D. WICKE, A. B. WICKLUND, E. WICKLUND, S. WILBUR, G. WILLIAMS, H. H. WILLIAMS, M. R. J. WILLIAMS, G. W. WILSON, P. WILSON, S. J. WIMPENNY, B. L. WINER, P. WITTICH, M. WOBISCH, S. WOLBERS, C. WOLFE, H. WOLFE, D. R. WOOD, T. WRIGHT, X. WU, F. WÜRTHWEIN, T. R. WYATT, Y. XIE, C. XU, S. YACOOB, A. YAGIL, R. YAMADA, K. YAMAMOTO, J. YAMAOKA, U. K. YANG,M, W.-C. YANG, Y. C. YANG, W. M. YAO, T. YASUDA, Y. A. YATSUNENKO, Z. YE, G. P. YEH, K. YI,I, H. YIN, K. YIP, J. YOH, H. D. YOO, K. YORITA, T. YOSHIDA,F, S. W. YOUN, G. B. YU, I. YU, J. YU, S. S. YU, J. C. YUN, A. ZANETTIA, C. ZEITNITZ, S. ZELITCH, Y. ZENG, X. ZHANG, T. ZHAO, Y. ZHENG, B. ZHOU, J. ZHU, M. ZIELINSKI, D. ZIEMINSKA, L. ZIVKOVIC, S. ZUCCHELLI, V. ZUTSHI, E. G. ZVEREV, D0 (Tevatron, IHEF, IOP, FNWI), Universidad de Buenos Aires, Centro Brasileiro de Pesquisas Físicas, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Federal do ABC (UFABC), Universidade Estadual Paulista (UNESP), McGill University, Simon Fraser University, University of Science and Technology of China, Academia Sinica, Universidad de los Andes, Faculty of Mathematics and Physics, Czech Technical University in Prague, Academy of Sciences, Universidad San Francisco de Quito, University of Helsinki, CNRS/IN2P3, Institut National Polytechnique de Grenoble, Irfu/SPP, RWTH Aachen University, Universität Bonn, Universität Freiburg, Georg-August-Universität Göttingen, Karlsruhe Institute of Technology, Universität Mainz, Ludwig-Maximilians-Universität München, University of Wuppertal, University of Athens, Panjab University, Delhi University, Tata Institute of Fundamental Research, University College Dublin, Istituto Nazionale di Fisica Nucleare Bologna, University of Bologna, Istituto Nazionale di Fisica Nucleare, Sezione di Padova-Trento, University of Padova, Istituto Nazionale di Fisica Nucleare Pisa, University of Pisa, University of Siena, Scuola Normale Superiore, Sezione di Roma 1, Sapienza Università di Roma, Istituto Nazionale di Fisica Nucleare Trieste/Udine, University of Trieste, Okayama University, Osaka City University, University of Tsukuba, Waseda University, Kyungpook National University, Korea University, SungKyunKwan University, CINVESTAV, NIKHEF, Radboud University Nijmegen/NIKHEF, Joint Institute for Nuclear Research, Institution for Theoretical and Experimental Physics, Moscow State University, Institute for High Energy Physics, Petersburg Nuclear Physics Institute, Comenius University, Universitat Autonoma de Barcelona, Medioambientales y Tecnologicas, University of Cantabria, Stockholm University, University of Geneva, Glasgow University, Lancaster University, University of Liverpool, Imperial College London, University College London, The University of Manchester, University of Oxford, University of Arizona, Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Yale University, University of Florida, Florida State University, Argonne National Laboratory, Fermi National Accelerator Laboratory, University of Chicago, University of Illinois at Chicago, Northern Illinois University, Northwestern University, University of Illinois, Indiana University, Purdue University Calumet, University of Notre Dame, Purdue University, Iowa State University, University of Kansas, Kansas State University, Louisiana Tech University, The Johns Hopkins University, University of Maryland, Boston University, Northeastern University, Harvard University, Massachusetts Institute of Technology, Tufts University, Brandeis University, University of Michigan, Wayne State University, Michigan State University, University of Mississippi, University of Nebraska, Rutgers University, Princeton University, University of New Mexico, State University of New York, Columbia University, The Rockefeller University, University of Rochester, Brookhaven National Laboratory, Duke University, The Ohio State University, Langston University, University of Oklahoma, Oklahoma State University, University of Pennsylvania, Carnegie Mellon University, University of Pittsburgh, Brown University, University of Texas, Texas A and M University, Southern Methodist University, Rice University, Baylor University, University of Virginia, University of Washington, University of Wisconsin, Sezione di Cagliari, University of Toronto, TRIUMF, York University, Seoul National University, Sungkyunkwan University, Institute of Science and Technology Information, Chonnam National University, Chonbuk National University, Institute of Experimental Physics, University of Cyprus, University of Edinburgh, Fukui Prefecture, Kinki University, Universidad Iberoamericana, University of Iowa, University of California Irvine, Cornell University, University of London, University of Manchester, Inc., Nagasaki Institute of Applied Science, Obninsk State University, University de Oviedo, Texas Tech University, CSIC-Universitat de Valencia, Universidad Tecnica Federico Santa Maria, Bergische Universität Wuppertal, Yarmouk University, J. Stefan Institute, Augustana College, SLAC, ICREA/IFAE, Centro de Investigacion en Computacion-IPN, Universidad Autonoma de Sinaloa, Universiẗt Bern, University of Massachusetts Amherst, Universiteit Antwerpen, University of Bristol, University of California Santa Cruz, Chinese Academy of Sciences, Clark, Allan Geoffrey, Garcia Navarro, Jose Enrique, Lister, Alison, and Wu, Xin

Subjects
Particle physics, Astrophysics::High Energy Astrophysical Phenomena, Tevatron, FOS: Physical sciences, General Physics and Astronomy, Elementary particle, ddc:500.2, PARTON DISTRIBUTIONS, HADRON COLLIDERS, QCD, NNLO, 7. Clean energy, 01 natural sciences, 114 Physical sciences, High Energy Physics - Experiment, Standard Model, Nuclear physics, High Energy Physics - Experiment (hep-ex), Particle decay, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Grand Unified Theory, Fermilab, TEVATRON, Nuclear Experiment, 010306 general physics, Boson, Physics, HIGGS BOSON, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, 3. Good health, Higgs boson, CDF, Physics::Accelerator Physics, High Energy Physics::Experiment, +W%2B+W-+|+W%3A+pair+production+|+W%3A+leptonic+decay+|+dilepton%3A+final+state+|+jet%3A+multiplicity+|+cross+section%3A+upper+limit+|+mass+dependence+|+Higgs+particle%3A+mass+|+background+|+DZERO+|+CDF+|+Batavia+TEVATRON+Coll+|+anti-p+p+-->+Higgs+particle+anything+|+anti-p+p+-->+Higgs+particle+anything+intermediate+boson+anything+|+anti-p+p+-->+Higgs+particle+anything+quark+antiquark+anything+|+1960+GeV-cms%22">Anti-p p: interaction | Higgs particle: search for | gluon gluon: fusion | intermediate boson: fusion | quark antiquark: annihilation | Higgs particle: decay | Higgs particle --> W+ W- | W: pair production | W: leptonic decay | dilepton: final state | jet: multiplicity | cross section: upper limit | mass dependence | Higgs particle: mass | background | DZERO | CDF | Batavia TEVATRON Coll | anti-p p --> Higgs particle anything | anti-p p --> Higgs particle anything intermediate boson anything | anti-p p --> Higgs particle anything quark antiquark anything | 1960 GeV-cms
Abstract

11 páginas, 4 figuras, 1 tabla.-- CDF Collaboration: et al., We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L., We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by DOE and NSF (USA), CONICET and UBACyT (Argentina), CNPq, FAPERJ, FAPESP and FUNDUNESP (Brazil), CRC Program, CFI, NSERC and WestGrid Project (Canada), CAS and CNSF (China), Colciencias (Colombia), MSMT and GACR (Czech Republic), Academy of Finland (Finland), CEA and CNRS/IN2P3 (France), BMBF and DFG (Germany), Ministry of Education, Culture, Sports, Science and Technology (Japan), World Class University Program, National Research Foundation (Korea), KRF and KOSEF (Korea), DAE and DST (India), SFI (Ireland),INFN (Italy), CONACyT (Mexico), NSC(Republic of China), FASI, Rosatom and RFBR (Russia), Slovak R&D Agency (Slovakia), Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010 (Spain), The Swedish Research Council (Sweden), Swiss National Science Foundation (Switzerland), FOM (The Netherlands), STFC and the Royal Society (UK), and the A.P. Sloan Foundation (USA).

Published
2010
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34. Sodium/hydrogen-exchanger-2 modulates colonocyte lineage differentiation.

Author

Nikolovska K, Cao L, Hensel I, Di Stefano G, Seidler AE, Zhou K, Qian J, Singh AK, Riederer B, and Seidler U

Subjects
Animals, Cell Lineage, Hydrogen-Ion Concentration, Mice, Microvilli metabolism, Sulfate Transporters metabolism, Colon cytology, Sodium-Hydrogen Exchangers genetics, Sodium-Hydrogen Exchangers metabolism
Abstract

Aim: The sodium/hydrogen exchanger 2 (NHE2) is an intestinal acid extruder with crypt-predominant localization and unresolved physiological significance. Our aim was to decipher its role in colonic epithelial cell proliferation, differentiation and electrolyte transport., Methods: Alterations induced by NHE2-deficiency were addressed in murine nhe2 -/- and nhe2 +/+ colonic crypts and colonoids, and NHE2-knockdown and control Caco2Bbe cells using pH-fluorometry, gene expression analysis and immunofluorescence., Results: pH i -measurements along the colonic cryptal axis revealed significantly decreased intracellular pH (pH i ) in the middle segment of nhe2 -/- compared to nhe2 +/+ crypts. Increased Nhe2 mRNA expression was detected in murine colonoids in the transiently amplifying/progenitor cell stage (TA/PE). Lack of Nhe2 altered the differentiation programme of colonic epithelial cells with reduced expression of absorptive lineage markers alkaline phosphatase (iAlp), Slc26a3 and transcription factor hairy and enhancer-of-split 1 (Hes1), but increased expression of secretory lineage markers Mucin 2, trefoil factor 3 (Tff3), enteroendocrine marker chromogranin A and murine atonal homolog 1 (Math1). Enterocyte differentiation was found to be pH i dependent with acidic pH i reducing, and alkaline pH i stimulating the expression of enterocyte differentiation markers in Caco2Bbe cells. A thicker mucus layer, longer crypts and an expanded brush border membrane zone of sodium/hydrogen exchanger 3 (NHE3) abundance may explain the lack of inflammation and the normal fluid absorptive rate in nhe2 -/- colon., Conclusions: The results suggest that NHE2 expression is activated when colonocytes emerge from the stem cell niche. Its activity increases progenitor cell pH i and thereby supports absorptive enterocyte differentiation., (© 2022 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.)

Published
2022
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35. Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.

Author

Flommersfeld S, Böttcher JP, Ersching J, Flossdorf M, Meiser P, Pachmayr LO, Leube J, Hensel I, Jarosch S, Zhang Q, Chaudhry MZ, Andrae I, Schiemann M, Busch DH, Cicin-Sain L, Sun JC, Gasteiger G, Victora GD, Höfer T, Buchholz VR, and Grassmann S

Subjects
Animals, Female, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Muromegalovirus, Adaptive Immunity immunology, Cell Lineage immunology, Herpesviridae Infections immunology, Immunity, Innate immunology, Killer Cells, Natural immunology
Abstract

Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2021
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36. Early emergence of T central memory precursors programs clonal dominance during chronic viral infection.

Author

Grassmann S, Mihatsch L, Mir J, Kazeroonian A, Rahimi R, Flommersfeld S, Schober K, Hensel I, Leube J, Pachmayr LO, Kretschmer L, Zhang Q, Jolly A, Chaudhry MZ, Schiemann M, Cicin-Sain L, Höfer T, Busch DH, Flossdorf M, and Buchholz VR

Subjects
Acute Disease, Animals, Biomarkers, Chronic Disease, Cytomegalovirus immunology, Cytomegalovirus Infections immunology, Cytomegalovirus Infections virology, Gene Expression Profiling, Humans, Immunophenotyping, Mice, Muromegalovirus immunology, Clonal Evolution immunology, Host-Pathogen Interactions immunology, Immunologic Memory, T-Lymphocyte Subsets immunology, T-Lymphocyte Subsets metabolism, Virus Diseases etiology, Virus Diseases metabolism
Abstract

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large CMV-specific T cell populations. The magnitude of this so-called 'memory inflation' is thought to mainly depend on antigenic stimulation during the chronic phase of infection. However, by mapping the long-term development of CD8 + T cell families derived from single naive precursors, we find that fate decisions made during the acute phase of murine CMV infection can alter the level of memory inflation by more than 1,000-fold. Counterintuitively, a T cell family's capacity for memory inflation is not determined by its initial expansion. Instead, those rare T cell families that dominate the chronic phase of infection show an early transcriptomic signature akin to that of established T central memory cells. Accordingly, a T cell family's long-term dominance is best predicted by its early content of T central memory precursors, which later serve as a stem-cell-like source for memory inflation.

Published
2020
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37. Disparate individual fates compose robust CD8+ T cell immunity.

Author

Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Weissbrich B, Gräf P, Verschoor A, Schiemann M, Höfer T, and Busch DH

Subjects
Adoptive Transfer, Animals, Cell Differentiation, Cell Lineage, Cell Proliferation, Clonal Selection, Antigen-Mediated, Computer Simulation, Immunophenotyping, Interferon-gamma biosynthesis, Interleukin-2 biosynthesis, Listeria monocytogenes, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Immunological, Single-Cell Analysis, Stochastic Processes, T-Cell Antigen Receptor Specificity, CD8-Positive T-Lymphocytes immunology, Immunity, Cellular, Immunologic Memory, Listeriosis immunology, T-Lymphocyte Subsets immunology
Abstract

A core feature of protective T cell responses to infection is the robust expansion and diversification of naïve antigen-specific T cell populations into short-lived effector and long-lived memory subsets. By means of in vivo fate mapping, we found a striking variability of immune responses derived from individual CD8(+) T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. Unbiased mathematical modeling identifies the random integration of multiple differentiation and division events as the driving force behind this variability. Within this probabilistic framework, cell fate is specified along a linear developmental path that progresses from slowly proliferating long-lived to rapidly expanding short-lived subsets. These data provide insights into how complex biological systems implement stochastic processes to guarantee robust outcomes.

Published
2013
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38. HIV drug resistance (HIVDR) in antiretroviral therapy-naïve patients in Tanzania not eligible for WHO threshold HIVDR survey is dramatically high.

Author

Kasang C, Kalluvya S, Majinge C, Stich A, Bodem J, Kongola G, Jacobs GB, Mlewa M, Mildner M, Hensel I, Horn A, Preiser W, van Zyl G, Klinker H, Koutsilieri E, Rethwilm A, Scheller C, and Weissbrich B

Subjects
Adult, Aging, Cohort Studies, Demography, Drug Monitoring, Female, HIV Infections epidemiology, HIV Infections transmission, HIV Infections virology, HIV-1 classification, HIV-1 genetics, Humans, Infectious Disease Transmission, Vertical prevention & control, Infectious Disease Transmission, Vertical statistics & numerical data, Male, Middle Aged, Molecular Sequence Data, Mutation genetics, Phylogeny, Tanzania epidemiology, Time Factors, Treatment Outcome, Young Adult, Anti-HIV Agents therapeutic use, Drug Resistance, Viral, Eligibility Determination statistics & numerical data, HIV Infections drug therapy, Health Care Surveys statistics & numerical data, World Health Organization
Abstract

Background: The World Health Organization (WHO) has recommended guidelines for a HIV drug resistance (HIVDR) survey for resource-limited countries. Eligibility criteria for patients include age below 25 years in order to focus on the prevalence of transmitted HIVDR (tHIVDR) in newly-infected individuals. Most of the participating sites across Africa have so far reported tHIVDR prevalences of below 5%. In this study we investigated whether the rate of HIVDR in patients <25 years is representative for HIVDR in the rest of the therapy-naïve population., Methods and Findings: HIVDR was determined in 88 sequentially enrolled ART-naïve patients from Mwanza, Tanzania (mean age 35.4 years). Twenty patients were aged <25 years and 68 patients were aged 25-63 years. The frequency of HIVDR in the study population was 14.8% (95%; CI 0.072-0.223) and independent of NVP-resistance induced by prevention of mother-to-child transmission programs. Patients >25 years had a significantly higher HIVDR frequency than younger patients (19.1%; 95% CI 0.095-0.28) versus 0%, P = 0.0344). In 2 out of the 16 patients with HIVDR we found traces of antiretrovirals (ARVs) in plasma., Conclusions: ART-naïve patients aged over 25 years exhibited significantly higher HIVDR than younger patients. Detection of traces of ARVs in individuals with HIVDR suggests that besides transmission, undisclosed misuse of ARVs may constitute a significant factor in the generation of the observed high HIVDR rate. The current WHO tHIVDR survey that is solely focused on the transmission of HIVDR and that excludes patients over 25 years of age may therefore result in substantial underestimation of the prevalence of HIVDR in the therapy-naïve population. Similar studies should be performed also in other areas to test whether the so far reported optimistic picture of low HIVDR prevalence in young individuals is really representative for the rest of the ART-naïve HIV-infected population.

Published
2011
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39. [A simple method for determination of the functional residual capacity during artificial ventilation (author's transl)].

Author

Stokke T, Hensel I, and Burchardi H

Subjects
Animals, Blood Pressure, Female, Male, Mathematics, Swine, Functional Residual Capacity, Lung Volume Measurements, Respiration, Artificial
Abstract

A simple method for determination of the functional residual capacity (FRC) during artificial ventilation by inert gas dilution using a rebreathing technique is described. The measurements can be made during various techniques of mechanical ventilation (eg. PEEP, IMV etc.). Myorelaxation is not required. This technique was used to assess the volume of a lung model (actual volume: 3670 ml) with the result of repeated measures being 3686 +/- 29 ml. Duplicate measurements in artificially ventilated pigs showed a coefficient of variation of +/- 3.2%. In artificially ventilated patients FRC was determined both with this technique and with a reference method, giving a difference of 111 +/- 55 ml (p less than 0.001). The errors in measurements of FRC by this method are small, and as the measurement requires a minimum of time and the apparatus is simple, the method is accurate and yet simple enough to be used on a routine basis in the intensive care unit. Even high risk patients are not disturbed by this technique. The method has the advantage that it can easily be learned by nurses and paramedical personal.

Published
1981

40. [Activating group work with residents of retirement and nursing homes].

Author

Löschner K and Hensel I

Subjects
Activities of Daily Living, Arousal, Communication, Humans, Social Environment, Aged psychology, Homes for the Aged, Nursing Homes, Psychotherapy, Group methods
Abstract

Taking care for older people in homes for the aged and nursing homes should be improved and broadened concerning a higher activity of these people. A very good method seems to be group work. In this investigation group sessions with people in a nursing home have been made during the time of half a year.

Published
1989

41. [Determination of pulmonary diffusing capacity during artificial ventilation (author's transl)].

Author

Stokke T, Röhrborn W, Hensel I, Hilfiker O, Braun U, and Burchardi H

Subjects
Adolescent, Adult, Anesthesia, General, Carbon Monoxide, Closing Volume, Female, Functional Residual Capacity, Humans, Male, Middle Aged, Posture, Pulmonary Diffusing Capacity, Regression Analysis, Respiration, Artificial
Abstract

Pulmonary diffusing capacity may be determined by rebreathing techniques using various test gases. The errors caused by functional inhomogenities are smaller with the rebreathing method than those found in the single-breath technique. However, until now there have been some disadvantages to the clinical application of the rebreathing technique. In the present paper, a modification of the rebreathing technique suggested by Piiper, Scheid, Meyer and Adaro (1975 and 1976), in which pulmonary diffusing capacity for carbon monoxide, DCO(RB), is measured, has been applied to intubated and anesthetised patients. Measurements were performed in 39 surgical patients with healthy lungs during artificial ventilation and narcosis. Under these conditions all patients had a DCO(RB) greater than or equal to 75 ml/min . kPa (10 ml/min.torr). The coefficient of variation for duplicate measurements was +/- 4.2%. In the same patients DCO-single-breath-measurements, DCO(SB), were also made. There was a significant (p less than 0.0001) correlation between DCO(RB) in artificially ventilated, anaesthetised patients in a supine position and DCO(SB) for spontaneously breathing, awake patients in a sitting position. A linear regression analysis of the data showed the DCO(SB) was related to DCO(RB) in the following manner: DCO(SB) = 1.62DCO(RB) = 4.44 (ml/min.torr) (r = 0.71, n = 39). The mean value of DCO(RB) was 53.4% of the mean value of DCO(SB). This difference may be due to the combination of different techniques used and different conditions during the measurements (reduced FRC, difference in F1O2 etc.). The histogramm of the distribution of DCO(RB) had a similar form to that of DCO(SB). The modified method has a high reproducibility and can easily be performed as a bed-side test without disturbance to patients with an endotracheal tube.

Published
1981

45. [Combination of piritramide and N 2 O--a new anesthetic procedure. II. Studies in man].

Author

Hempelmann G, Kettler D, Holzhäuser H, Hempelmann W, Hensel I, Karliczek G, and Kirchner E

Subjects
Adult, Aged, Blood Gas Analysis, Blood Pressure drug effects, Blood Volume drug effects, Cardiac Output drug effects, Heart Rate drug effects, Humans, Lacrimal Apparatus drug effects, Middle Aged, Nitriles adverse effects, Oxygen, Piperidines adverse effects, Preanesthetic Medication, Pupil drug effects, Sweat Glands drug effects, Sweating, Venous Pressure drug effects, Anesthesia, Endotracheal, Isonipecotic Acids adverse effects, Nitrous Oxide
Published
1971

47. [Effect of 1,4-bis(3-(3,4,5-trimethoxybenzoyl-oxy)-propyl)-perhydro-1,4-diazepine dihydrochloride on cardiac metabolism, hemodynamics and coronary and renal blood flow].

Author

Hensel I, Bretschneider HJ, Kettler D, Knoll D, Kochsiek K, Reploh HD, Spieckermann PG, and Tauchert M

Subjects
Adenosine metabolism, Adolescent, Adult, Animals, Azepines administration & dosage, Benzoates administration & dosage, Benzoates pharmacology, Cardiac Catheterization, Coronary Circulation drug effects, Coronary Vessels drug effects, Dogs, Electrocardiography, Hemodynamics drug effects, Humans, Kidney blood supply, Myocardium metabolism, Oxygen Consumption drug effects, Regional Blood Flow drug effects, Vasodilator Agents administration & dosage, Azepines pharmacology, Blood Circulation drug effects, Heart drug effects, Vasodilator Agents pharmacology
Published
1972

48. [Studies on circulatory and metabolic changes during ketamine anaesthesia].

Author

Hensel I, Braun U, Kettler D, Knoll D, Martel J, and Paschen K

Subjects
Acid-Base Equilibrium drug effects, Anesthesia, Intravenous, Animals, Blood Glucose, Blood Pressure drug effects, Dogs, Epinephrine blood, Fatty Acids blood, Heart Rate drug effects, Norepinephrine blood, Oxygen Consumption drug effects, Pancuronium pharmacology, Anesthetics pharmacology, Cyclohexanes pharmacology, Hemodynamics drug effects, Ketamine, Metabolism drug effects
Published
1972

49. [Combination of piritramide and N 2 O--a new anesthetic procedure. I. Animal experiment studies].

Author

Kettler D, Braun U, Cott LA, Heiss HW, Hensel I, Martel J, Paschen K, and Bretschneider HJ

Subjects
Anesthesia, Inhalation, Animals, Blood Pressure drug effects, Cardiac Output drug effects, Dogs, Electrocardiography, Halothane, Heart Rate drug effects, Kidney blood supply, Kidney drug effects, Neuroleptanalgesia, Nitriles, Piperidines, Preanesthetic Medication, Scopolamine, Toxiferine, Vascular Resistance drug effects, Anesthesia, Endotracheal, Isonipecotic Acids, Nitrous Oxide
Published
1971

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