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6. Corrigendum to “Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action [European Neuropsychopharmacology (2020) 36, 121–136]” (European Neuropsychopharmacology (2020) 36 (121–136), (S0924977X20301802), (10.1016/j.euroneuro.2020.05.006))

Author

Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), González-Pinto, A. (Ana), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), Andreassen, O.A. (Ole), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), González-Pinto, A. (Ana), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), and Andreassen, O.A. (Ole)

Abstract

The authors regret that there was an error in the author list, this should appear as above. The authors apologise for any inconvenience caused.

Published
2021
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10. Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action

Author

Manchia, M. (Mriko), Vieta, E. (Eduard), Smeland, O.B. (Olav B.), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), Pinto, A.G. (Ana Gonzalez), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), Andreassen, O.A. (Ole), Manchia, M. (Mriko), Vieta, E. (Eduard), Smeland, O.B. (Olav B.), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), Pinto, A.G. (Ana Gonzalez), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), and Andreassen, O.A. (Ole)

Abstract

Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus that the accurate identification of the underlying pathophysiology for BD is fundamental to realize major health benefits through better treatment and preventive regimens. However, to achieve these goals requires coordinated action and innovative approaches to boost the discovery of the neurobiological underpinnings of BD, and rapid translation of research findings into development and testing of better and more specific treatments. To this end, we here propose that only a large-scale coordinated action can be successful in integrating international big-data approaches with real-world clinical interventions. This could be achieved through the creation of a Global Bipolar Disorder Foundation, which could bring government, industry and philanthropy together in common cause. A global initiative for BD research would come at a highly opportune time given the seminal advances promised for our understanding of the genetic and brain basis of the disease and the obvious areas of unmet clinical need. Such an endeavour would embrace the principles of open science and see the strong involvement of user groups and integration of dissemin

Published
2020
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11. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Author

Ching, C.R.K. (Christopher), Hibar, D.P. (Derrek P.), Gurholt, T.P. (Tiril P.), Nunes, A. (Abraham), Thomopoulos, S.I. (Sophia I.), Abé, C. (Christoph), Agartz, I. (Ingrid), Brouwer, R.M. (Rachel), Cannon, D.M. (Dara), de Zwarte, S.M.C. (Sonja M. C.), Eyler, L.T. (Lisa T.), Favre, P. (Pauline), Hajek, T. (Tomas), Haukvik, U.K. (Unn), Houenou, J. (Josselin), Landén, M. (Mikael), Lett, T.A. (Tristram A.), McDonald, C. (Colm), Nabulsi, L. (Leila), Patel, Y. (Yash), Pauling, M.E. (Melissa E.), Paus, T. (Tomas), Radua, J. (Joaquim), Soeiro-de-Souza, M.G. (Marcio G.), Tronchin, G. (Giulia), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Walter, H.J. (Henrik), Zeng, L.-L. (Ling-Li), Alda, M. (Martin), Almeida, J. (Jorge), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Altimus, C. (Cara), Bauer, M. (Michael), Baune, B.T., Bearden, C.E. (Carrie), Bellani, M. (Marcella), Benedetti, F. (Francesco), Berk, M. (Michael), Bilderbeck, A.C. (Amy C.), Blumberg, H.P. (Hilary P.), Bøen, E. (Erlend), Bollettini, I. (Irene), del Mar Bonnin, C. (Caterina), Brambilla, P. (Paolo), Canales-Rodríguez, E.J. (Erick J.), Caseras, X. (Xavier), Dandash, O. (Orwa), Dannlowski, U. (Udo), Delvecchio, G. (Giuseppe), Díaz-Zuluaga, A.M. (Ana M.), Dima, D. (Danai), Duchesnay, É. (Édouard), Elvsåshagen, T. (Torbjørn), Fears, S. (Scott), Frangou, S. (Sophia), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Green, M.J. (Melissa J.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Haarman, B.C.M. (Benno), Henry, C. (C.), Howells, F.M. (Fleur M.), Ives-Deliperi, V. (Victoria), Jansen, A. (Andreas), Kircher, T.T.J. (Tilo T. J.), Knöchel, C. (Christian), Kramer, B. (Bernd), Lafer, B. (Beny), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), MacIntosh, B.J. (Bradley J), Melloni, E.M.T. (Elisa M. T.), Mitchell, P.B. (Philip B.), Nenadic, I. (Igor), Nery, F. (Fabiano), Nugent, A.C. (Allison), Oertel, V. (Viola), Ophoff, R.A. (Roel), Ota, M. (Miho), Overs, B.J. (Bronwyn J.), Pham, D.L. (Daniel L.), Phillips, M.L. (Mary L.), Pineda-Zapata, J.A. (Julian A.), Poletti, S. (Sara), Polosan, M. (Mircea), Pomarol-Clotet, E. (Edith), Pouchon, A. (Arnaud), Quidé, Y. (Yann), Rive, M.M. (Maria M.), Roberts, G. (Gloria), Ruhé, H.G. (Henricus G.Eric), Salvador, R. (Raymond), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Schene, A.H. (Aart), Sim, K. (Kang), Soares, J.C. (Jair C.), Stäblein, M. (Michael), Stein, D.J. (Dan J.), Tamnes, C.K. (Christian K.), Thomaidis, G.V. (Georgios V.), Upegui, C.V. (Cristian Vargas), Veltman, D.J. (Dick), Wessa, M. (Michèle), Westlye, L.T. (Lars), Whalley, H.C. (Heather C.), Wolf, D.H. (Daniel H.), Wu, M.-J. (Mon-Ju), Yatham, L.N. (Lakshmi N.), Zarate, C.A. (Carlos A.), Thompson, P.M. (Paul), Andreassen, O.A. (Ole), Ching, C.R.K. (Christopher), Hibar, D.P. (Derrek P.), Gurholt, T.P. (Tiril P.), Nunes, A. (Abraham), Thomopoulos, S.I. (Sophia I.), Abé, C. (Christoph), Agartz, I. (Ingrid), Brouwer, R.M. (Rachel), Cannon, D.M. (Dara), de Zwarte, S.M.C. (Sonja M. C.), Eyler, L.T. (Lisa T.), Favre, P. (Pauline), Hajek, T. (Tomas), Haukvik, U.K. (Unn), Houenou, J. (Josselin), Landén, M. (Mikael), Lett, T.A. (Tristram A.), McDonald, C. (Colm), Nabulsi, L. (Leila), Patel, Y. (Yash), Pauling, M.E. (Melissa E.), Paus, T. (Tomas), Radua, J. (Joaquim), Soeiro-de-Souza, M.G. (Marcio G.), Tronchin, G. (Giulia), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Walter, H.J. (Henrik), Zeng, L.-L. (Ling-Li), Alda, M. (Martin), Almeida, J. (Jorge), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Altimus, C. (Cara), Bauer, M. (Michael), Baune, B.T., Bearden, C.E. (Carrie), Bellani, M. (Marcella), Benedetti, F. (Francesco), Berk, M. (Michael), Bilderbeck, A.C. (Amy C.), Blumberg, H.P. (Hilary P.), Bøen, E. (Erlend), Bollettini, I. (Irene), del Mar Bonnin, C. (Caterina), Brambilla, P. (Paolo), Canales-Rodríguez, E.J. (Erick J.), Caseras, X. (Xavier), Dandash, O. (Orwa), Dannlowski, U. (Udo), Delvecchio, G. (Giuseppe), Díaz-Zuluaga, A.M. (Ana M.), Dima, D. (Danai), Duchesnay, É. (Édouard), Elvsåshagen, T. (Torbjørn), Fears, S. (Scott), Frangou, S. (Sophia), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Green, M.J. (Melissa J.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Haarman, B.C.M. (Benno), Henry, C. (C.), Howells, F.M. (Fleur M.), Ives-Deliperi, V. (Victoria), Jansen, A. (Andreas), Kircher, T.T.J. (Tilo T. J.), Knöchel, C. (Christian), Kramer, B. (Bernd), Lafer, B. (Beny), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), MacIntosh, B.J. (Bradley J), Melloni, E.M.T. (Elisa M. T.), Mitchell, P.B. (Philip B.), Nenadic, I. (Igor), Nery, F. (Fabiano), Nugent, A.C. (Allison), Oertel, V. (Viola), Ophoff, R.A. (Roel), Ota, M. (Miho), Overs, B.J. (Bronwyn J.), Pham, D.L. (Daniel L.), Phillips, M.L. (Mary L.), Pineda-Zapata, J.A. (Julian A.), Poletti, S. (Sara), Polosan, M. (Mircea), Pomarol-Clotet, E. (Edith), Pouchon, A. (Arnaud), Quidé, Y. (Yann), Rive, M.M. (Maria M.), Roberts, G. (Gloria), Ruhé, H.G. (Henricus G.Eric), Salvador, R. (Raymond), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Schene, A.H. (Aart), Sim, K. (Kang), Soares, J.C. (Jair C.), Stäblein, M. (Michael), Stein, D.J. (Dan J.), Tamnes, C.K. (Christian K.), Thomaidis, G.V. (Georgios V.), Upegui, C.V. (Cristian Vargas), Veltman, D.J. (Dick), Wessa, M. (Michèle), Westlye, L.T. (Lars), Whalley, H.C. (Heather C.), Wolf, D.H. (Daniel H.), Wu, M.-J. (Mon-Ju), Yatham, L.N. (Lakshmi N.), Zarate, C.A. (Carlos A.), Thompson, P.M. (Paul), and Andreassen, O.A. (Ole)

Abstract

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studi

Published
2020
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17. Paediatric kidney transplants from donors aged 1 year and under: an analysis of the Australian and New Zealand Dialysis and Transplant Registry from 1963 to 2018

Author

Yao, Jinna, primary, Clayton, Philip A., additional, Wyburn, Kate, additional, Choksi, Harsham, additional, Cavazzoni, Elena, additional, Tovmassian, David, additional, Lau, Howard M. H., additional, Allen, Richard, additional, Yuen, Lawrence, additional, Laurence, Jerome M., additional, Lam, Vincent W. T., additional, and Pleass, Henry C. C., additional

Published
2020
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26. Correction to: Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy (Surgical Endoscopy, (2018), 10.1007/s00464-018-6281-2)

Author

Griffiths, Ewen A., Hodson, James, Vohra, Ravi S., Marriott, Paul, Katbeh, Tarek, Zino, Samer, Nassar, Ahmad H. M., Vohra, Ravinder S., Kirkham, Amanda J., Pasquali, Sandro, Johnstone, Marianne, Spreadborough, Philip, Alderson, Derek, Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin M., Kennedy, David, Khan, Raja Basit, Khan, Muhammad A. S., Magee, Conor J., Jones, Steven M., Mason, Denise, Parappally, Ciny P., Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer Ul, Zafar, Sara, Shiwani, Muhammad Hanif, Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Fletcher, Ted, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S., Watkin, Helen, Naumann, David, Emesih, Sophie, Sarmah, Piyush B., Lee, Kathryn, Joji, Nikita, Lambert, Joel, Heath, Jonathan, Teasdale, Rebecca L., Weerasinghe, Chamindri, Needham, Paul J., Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M., Robb, William, Mcnair, Angus G. K., Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga V. G., Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J., Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B., Wei-Min, Ho, Miu, Victor, White, Timothy J., Hodgkins, Kathryn A., Kinghorn, Alison, Tutton, Matthew G., Al-Abed, Yahya A., Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J., Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J., Mccallum, Iain J. D., Jones, Michael J., Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B., Kimble, Adam, Bunting, David M., Fawole, Adeshina S., Basheer, Mohammed, Dave, Rajiv V., Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P., Gough, Martin, Wallace, Tom, Singh, Shailendra, Mockford, Justine Downing Katherine A., Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R., Forouzanfar, Amir, Wild, Jonathan R. L., Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra T. V., Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C., Gould, Laura, Chambers, Alice, Rodriguez, Daniel Urriza, Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M., Stevenson, Thomas E. J., Sarvananthan, Kas, Dwerryhouse, Simon J., Higgs, Simon M., Old, Oliver J., Hardy, Thomas J., Hornby, Reena Shah Steve T., Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A., Frame, Richard J., Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O., Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee Sing, Fleming, Katie, Bajwa, Dalvir S., Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Mohamed, Simon Lammy Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A., Bellini, Maria Irene, Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Iqbal, Lola Giwa Nusrat, Watson, Nicholas F., Aggarwal, Smeer Kumar, Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D., Mok, Kam Wa Jessica, Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I., Dennison, A. R., Malde, Deep, Lloyd, David, Satheesan, Steve, Al-Taan, Omer, Boddy, Alexander, Slavin, John P., Jones, Robert P., Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M., Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R., Sampat, Keerthika, O’Shea, Kathryn M., Manu, Mangta, Asprou, Fotini M., Malik, Nabeela S., Chang, Jessica, Lewis, Michael, Roberts, Geoffrey P., Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O’Reilly, Derek A., Rate, Anthony J., Sekhar, Hema, Henderson, Lucy T., Starmer, Benjamin Z., Coe, Peter O., Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander E. J., Borowski, David W., Hornsby, Jane, Courtney, Michael J., Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V., Reid, Alistair, Wood, Peter, Finch, J. G., Guy Finch, J., Parmar, J., Stirland, E., Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M., Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R., Al-Khyatt, Waleed, Bhandari, Christopher Taylor Santosh, Chambers, Adam, Subramanium, Dhivya, Toh, Simon K. C., Carter, Nicholas C., Tate, Sophie, Pearce, Belinda, Wainwright, Denise, Mercer, Stuart J., Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S., Hussain, Abdulzahra A., Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N., Chishti, Imran A., Fordham, Imogen J., Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish Kiran, Basu, Sanjoy, Harilingam, Alok Chhabra Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F., Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I., Ball, William R., Wood, Christopher P. J., Pinho-Gomes, Ana C., Kausar, Ambareen, Obeidallah, Moh’d Rami, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Yusuf, Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R., Goh, Yan Li, Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina A. W., Sukha, Anisha, Preston, Shaun R., Hoban, Jennifer R., Puntis, Daniel J., Williams, Sophie V., Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H., Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T., Sheel, Andrea R. G., Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, Mcglone, Emma R., Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A., Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R., Yeldham, Geoffrey, Read, Edward, Gossage, James A., Rolph, Rachel C., Ebied, Husam, Phull, Manraj, Khan, Mohammad A., Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R., Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A., Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Amari, Khalid Al, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R., Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P., Pearson, Katherine L., Delisle, Theo G., Davies, James, Tomlinson, Mark A., Johnpulle, Michelle A., Slawinski, Corinna, Macdonald, Andrew, Nicholson, James, Newton, Katy, Mbuvi, James, Farooq, Ansar, Mothe, Bhavani Sidhartha, Zafrani, Zakhi, Brett, Daniel, Francombe, James, Barnes, James, Cheung, Melanie, Al-Bahrani, Ahmed Z., Preziosi, Giuseppe, Urbonas, Tomas, Alberts, Justin, Mallik, Mekhlola, Patel, Krashna, Segaran, Ashvina, Doulias, Triantafyllos, Sufi, Pratik A., Yao, Caroline, Pollock, Sarah, Manzelli, Antonio, Wajed, Saj, Kourkulos, Michail, Pezzuto, Roberto, Wadley, Martin, Hamilton, Emma, Jaunoo, Shameen, Padwick, Robert, Sayegh, Mazin, Newton, Richard C., Hebbar, Madhusoodhana, Farag, Sameh F., Spearman, John, Hamdan, Mohammed F., D’Costa, Conrad, Blane, Christine, Giles, Mathew, Peter, Mark B., Hirst, Natalie A., Hossain, Tanvir, El-Dhuwaib, Arslan Pannu Yesar, Morrison, Tamsin E. M., Taylor, Greg W., Thompson, Ronald L. E., Mccune, Ken, Loughlin, Paula, Lawther, Roger, Byrnes, Colman K., Simpson, Duncan J., Mawhinney, Abi, Warren, Conor, Mckay, Damian, Mcilmunn, Colin, Martin, Serena, Macartney, Matthew, Diamond, Tom, Davey, Phil, Jones, Claire, Clements, Joshua M., Digney, Ruairi, Chan, Wei Ming, Mccain, Stephen, Gull, Sadaf, Janeczko, Adam, Dorrian, Emmet, Harris, Andrew, Dawson, Suzanne, Johnston, Dorothy, Mcaree, Barry, Ghareeb, Essam, Thomas, George, Connelly, Martin, Mckenzie, Stephen, Cieplucha, Krzysztos, Spence, Gary, Campbell, William, Hooks, Gareth, Bradley, Neil, Hill, Arnold D. K., Cassidy, John T., Boland, Michael, Burke, Paul, Nally, Deirdre M., Khogali, Elmoataz, Shabo, Wael, Iskandar, Edrin, Mcentee, Gerry P., O’Neill, Maeve A., Peirce, Colin, Lyons, Emma M., O’Sullivan, Adrian W., Thakkar, Rohan, Carroll, Paul, Ivanovski, Ivan, Balfe, Paul, Lee, Matthew, Winter, Des C., Kelly, Michael E., Hoti, Emir, Maguire, Donal, Karunakaran, Priyadarssini, Geoghegan, Justin G., Mcdermott, Frank, Martin, Sean T., Cross, Keith S., Cooke, Fiachra, Zeeshan, Saquib, Murphy, James O., Mealy, Ken, Mohan, Helen M., Nedujchelyn, Yuwaraja, Ullah, Muhammad Fahad, Ahmed, Irfan, Giovinazzo, Francesco, Milburn, James, Prince, Sarah, Brooke, Eleanor, Buchan, Joanna, Khalil, Ahmed M., Vaughan, Elizabeth M., Ramage, Michael I., Aldridge, Roland C., Gibson, Simon, Nicholson, Gary A., Vass, David G., Grant, Alan J., Holroyd, David J., Angharad Jones, M., Sutton, Cherith M. L. R., O’Dwyer, Patrick, Nilsson, Frida, Weber, Beatrix, Williamson, Tracey K., Lalla, Kushik, Bryant, Alice, Ross Carter, C., Forrest, Craig R., Hunter, David I., Nassar, Ahmad H., Orizu, Mavis N., Knight, Katrina, Qandeel, Haitham, Suttie, Stuart, Belding, Rowena, Mcclarey, Andrew, Boyd, Alan T., Guthrie, Graeme J. K., Lim, Pei J., Luhmann, Andreas, Watson, Angus J. M., Richards, Colin H., Nicol, Laura, Madurska, Marta, Harrison, Ewen, Boyce, Kathryn M., Roebuck, Amanda, Ferguson, Graeme, Pati, Pradeep, Wilson, Michael S. J., Dalgaty, Faith, Fothergill, Laura, Driscoll, Peter J., Mozolowski, Kirsty L., Banwell, Victoria, Bennett, Stephen P., Rogers, Paul N., Skelly, Brendan L., Rutherford, Claire L., Mirza, Ahmed K., Lazim, Taha, Lim, Henry C. C., Duke, Diana, Ahmed, Talat, Beasley, William D., Wilkinson, Marc D., Maharaj, Geta, Malcolm, Cathy, Brown, Timothy H., Al-Sarireh, Bilal, Shingler, Guy M., Mowbray, Nicholas, Radwan, Rami, Morcous, Paul, Wood, Simon, Kadhim, Abbas, Stewart, Duncan J., Baker, Andrew L., Tanner, Nicola, Shenoy, Hrishikesh, Hafiz, Shazia, De Marchi, Joshua A., Singh-Ranger, Deepak, Hisham, Elzanati, Ainley, Paul, John Terrace, Stephen O’Neill., Napetti, Sara, Hopwood, Benjamin, Rhys, Thomas, Downing, Justine, Kanavati, Osama, Coats, Maria, Aleksandrov, Danail, Kallaway, Charlotte, Yahya, Salama, Templeton, Alexa, Trotter, Martin, Christina, Lo, Dhillon, Ajit, Heywood, Nick, Aawsaj, Yousif, Hamdan, Alhafidz, Reece-Bolton, Obuobi, Mcguigan, Andrew, Shahin, Yousef, Aymon, Null, Luther, Ali Alison, Nicholson, James A., Rajendran, Ilayaraja, Boal, Matthew, and Ritchie, Judith

Subjects
Surgery
Published
2018

27. Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

Author

Nunes, A. (Abraham), Schnack, H. (Hugo), Ching, C.R.K. (Christopher), Agartz, I. (Ingrid), Akudjedu, T.N. (Theophilus N.), Alda, M. (Martin), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Bauer, J. (Jochen), Baune, B.T., Bøen, E. (Erlend), Bonnin, C.M. (Caterina del Mar), Busatto, G.F. (Geraldo F.), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara), Caseras, X. (Xavier), Chaim-Avancini, T.M. (Tiffany M.), Dannlowski, U. (Udo), Díaz-Zuluaga, A.M. (Ana M.), Dietsche, B. (Bruno), Doan, N.T. (Nhat Trung), Duchesnay, E. (Edouard), Elvsåshagen, T. (Torbjørn), Emden, D. (Daniel), Eyler, L.T. (Lisa T.), Fatjó-Vilas, M. (Mar), Favre, P. (Pauline), Foley, S.F. (Sonya F.), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Grotegerd, D. (Dominik), Hahn, T. (Tim), Henry, C. (C.), Hibar, D.P. (Derrek P.), Houenou, J. (Josselin), Howells, F.M. (Fleur M.), Jahanshad, N. (Neda), Kaufmann, T. (Tobias), Kenney, J. (Joanne), Kircher, T.T.J. (Tilo T. J.), Krug, A. (Axel), Lagerberg, T.V. (Trine V.), Lenroot, R.K. (Rhoshel), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), Malt, U.F. (Ulrik), McDonald, C. (Colm), Mitchell, P.B. (Philip B.), Mwangi, B. (Benson), Nabulsi, L. (Leila), Opel, N. (Nils), Overs, B.J. (Bronwyn J.), Pineda-Zapata, J.A. (Julian A.), Pomarol-Clotet, E. (Edith), Redlich, R. (Ronny), Roberts, G. (Gloria), Rosa, P.G. (Pedro G.), Salvador, R. (Raymond), Satterthwaite, T.D. (Theodore), Soares, J.C. (Jair C.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Trappenberg, T. (Thomas), Uhlmann, A. (Anne), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Westlye, L.T. (Lars), Wolf, D.H. (Daniel H.), Yüksel, D. (Dilara), Zanetti, M.V. (Marcus V.), Andreassen, O.A. (Ole), Thompson, P.M. (Paul), Hajek, T. (Tomas), Nunes, A. (Abraham), Schnack, H. (Hugo), Ching, C.R.K. (Christopher), Agartz, I. (Ingrid), Akudjedu, T.N. (Theophilus N.), Alda, M. (Martin), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Bauer, J. (Jochen), Baune, B.T., Bøen, E. (Erlend), Bonnin, C.M. (Caterina del Mar), Busatto, G.F. (Geraldo F.), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara), Caseras, X. (Xavier), Chaim-Avancini, T.M. (Tiffany M.), Dannlowski, U. (Udo), Díaz-Zuluaga, A.M. (Ana M.), Dietsche, B. (Bruno), Doan, N.T. (Nhat Trung), Duchesnay, E. (Edouard), Elvsåshagen, T. (Torbjørn), Emden, D. (Daniel), Eyler, L.T. (Lisa T.), Fatjó-Vilas, M. (Mar), Favre, P. (Pauline), Foley, S.F. (Sonya F.), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Grotegerd, D. (Dominik), Hahn, T. (Tim), Henry, C. (C.), Hibar, D.P. (Derrek P.), Houenou, J. (Josselin), Howells, F.M. (Fleur M.), Jahanshad, N. (Neda), Kaufmann, T. (Tobias), Kenney, J. (Joanne), Kircher, T.T.J. (Tilo T. J.), Krug, A. (Axel), Lagerberg, T.V. (Trine V.), Lenroot, R.K. (Rhoshel), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), Malt, U.F. (Ulrik), McDonald, C. (Colm), Mitchell, P.B. (Philip B.), Mwangi, B. (Benson), Nabulsi, L. (Leila), Opel, N. (Nils), Overs, B.J. (Bronwyn J.), Pineda-Zapata, J.A. (Julian A.), Pomarol-Clotet, E. (Edith), Redlich, R. (Ronny), Roberts, G. (Gloria), Rosa, P.G. (Pedro G.), Salvador, R. (Raymond), Satterthwaite, T.D. (Theodore), Soares, J.C. (Jair C.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Trappenberg, T. (Thomas), Uhlmann, A. (Anne), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Westlye, L.T. (Lars), Wolf, D.H. (Daniel H.), Yüksel, D. (Dilara), Zanetti, M.V. (Marcus V.), Andreassen, O.A. (Ole), Thompson, P.M. (Paul), and Hajek, T. (Tomas)

Abstract

Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings neuroimaging analyses to individual subject level and may potentially allow for their diagnostic use. However, fair and optimal application of ML requires large, multi-site datasets. We applied ML (support vector machines) to MRI data (regional cortical thickness, surface area, subcortical volumes) from 853 BD and 2167 control participants from 13 cohorts in the ENIGMA consortium. We attempted to differentiate BD from control participants, investigated different data handling strategies and studied the neuroimaging/clinical features most important for classification. Individual site accuracies ranged from 45.23% to 81.07%. Aggregate subject-level analyses yielded the highest accuracy (65.23%, 95% CI = 63.47–67.00, ROC-AUC = 71.49%, 95% CI = 69.39–73.59), followed by leave-one-site-out cross-validation (accuracy = 58.67%, 95% CI = 56.70–60.63). Meta-analysis of individual site accuracies did not provide above chance results. There was substantial agreement between the regions that contributed to identification of BD participants in the best performing site and in the aggregate dataset (Cohen’s Kappa = 0.83, 95% CI = 0.829–0.831). Treatment with anticonvulsants and age were associated with greater odds of correct classification. Although short of the 80% clinically relevant accuracy threshold, the resul

Published
2018
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28. Paediatric kidney transplants from donors aged 1 year and under: an analysis of the Australian and New Zealand Dialysis and Transplant Registry from 1963 to 2018.

Author

Yao, Jinna, Clayton, Philip A., Wyburn, Kate, Choksi, Harsham, Cavazzoni, Elena, Tovmassian, David, Lau, Howard M. H., Allen, Richard, Yuen, Lawrence, Laurence, Jerome M., Lam, Vincent W. T., and Pleass, Henry C. C.

Subjects
KIDNEY transplantation, TRANSPLANTATION of organs, tissues, etc., SURGICAL complications, AUSTRALIANS, AGE
Abstract

Summary: Kidneys from very small donors have the potential to significantly expand the donor pool. We describe the collective experience of transplantation using kidneys from donors aged ≤1 year in Australian and New Zealand. The ANZDATA registry was analysed on all deceased donor kidney transplants from donors aged ≤1 year. We compared recipient characteristics and outcomes between 1963–1999 and 2000–2018. From 1963 to 1999, 16 transplants were performed [9 (56%) adults, 7 (44%) children]. Death‐censored graft survival was 50% and 43% at 1 and 5 years, respectively. Patient survival was 90% and 87% at 1 and 5 years, respectively. From 2000 to 2018, 26 transplants were performed [25 (96%) adults, 1 (4%) children]. Mean creatinine was 73 µmol/l ±49.1 at 5 years. Death‐censored graft survival was 85% at 1 and 5 years. Patient survival was 100% at 1 and 5 years. Thrombosis was the cause of graft loss in 12% of recipients in the first era from 1963 to 1999, and 8% of recipients in the second era from 2000 to 2018. We advocate the judicious use of these small paediatric grafts from donors ≤1 year old. Optimal selection of donor and recipients may lead to greater acceptance and success of transplantation from very young donors. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Challenges of kidney paired donation transplants involving multiple donor and recipient surgeons across Australia

Author

Richard D M, Allen, Henry C C, Pleass, Claudia, Woodroffe, Philip A, Clayton, and Paolo, Ferrari

Subjects
Adult, Graft Rejection, Male, Tissue and Organ Procurement, Cold Ischemia, Graft Survival, Australia, Organ Preservation, Middle Aged, Kidney Transplantation, Risk Assessment, Survival Analysis, Statistics, Nonparametric, Cohort Studies, Young Adult, Living Donors, Humans, Female, Longitudinal Studies, Program Development, Program Evaluation
Abstract

The Australian kidney paired donation program adopted the principles of within-chain simultaneous live donor surgery and of organ transport, with the requirement of keeping cold ischemia time (CIT) to12 h. Whether these principles could be adhered to and what impact on transplant outcome they might have is unknown.We evaluated the logistic challenges and outcomes of the first 100 kidney transplants performed in the Australian kidney paired donation program.Within 4 years, 17 donor surgeons at 12 centres were involved in 37 chain exchange surgeries. Sixteen kidneys were transplanted at the same hospital and 84 required transport to the recipient hospital. Mean (±SD) within chain anaesthetic induction time variability was 8 ± 18 min and mean individual surgeon operating time was 115 ± 44 min. In two cases, delays during donor surgery resulted in increased CIT by 1 h because of deferred transport. CIT was 2.6 ± 0.6 h for non-shipped and 6.8 ± 2.8 h for shipped kidneys, four kidneys had CIT of 12-14 h. Immediate allograft function was observed in 85% of recipients, with no difference between shipped and non-shipped kidneys. There were only two cases of delayed graft function requiring temporary dialysis; both had CIT7 h. There was no difference in serum creatinine at 1 month between non-shipped and shipped kidneys (105 ± 26 versus 112 ± 50 µmol/L) and allograft survival at 1 year was 97%.The study provided a favourable audit of kidney transplant activity, despite challenges of simultaneous surgery, organ transport coordination and prolonged CIT. The decision to ship donor kidneys rather than the donor was demonstrated to be feasible and safe.

Published
2015

33. Impact of F18-fluorodeoxyglycose positron emission tomography/computed tomography on the management of resectable pancreatic tumours

Author

Jinna, Yao, Gary, Gan, David, Farlow, Jerome M, Laurence, Michael, Hollands, Arthur, Richardson, Henry C C, Pleass, and Vincent W T, Lam

Subjects
Adult, Male, Bone Neoplasms, Adenocarcinoma, Multimodal Imaging, Sensitivity and Specificity, Decision Support Techniques, Pancreatectomy, Fluorodeoxyglucose F18, Preoperative Care, Humans, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Cystadenoma, Serous, Liver Neoplasms, Middle Aged, Pancreatic Neoplasms, Neuroendocrine Tumors, Pancreatitis, Lymphatic Metastasis, Positron-Emission Tomography, Female, Radiopharmaceuticals, Tomography, X-Ray Computed, Follow-Up Studies
Abstract

Positron emission tomography/computed tomography (PET/CT) using F18-fluorodeoxyglucose has been shown to be valuable in the management of malignant disease. The aim of this study is to investigate the impact of this technique on the management of patients with resectable pancreatic tumours.Thirty-six patients with 37 potentially resectable pancreatic tumours on diagnostic CT imaging underwent PET/CT scans. Operative findings, histological reports and/or clinical follow-up served as standard of reference. The impact of PET/CT on patient management was estimated by calculating the percentage of patients whose treatment plan was altered due to PET/CT.Pancreatic adenocarcinoma was diagnosed in 30 patients, neuroendocrine tumours in 3, mass-forming pancreatitis in 3 and serous cystadenoma in 1. The median standard uptake (max) value was 5.0 (range 2.2-12.0). Sensitivity and specificity of detecting extrapancreatic metastatic disease were 73% and 100%, respectively. Three occult liver metastases were detected at laparotomy following negative PET/CT. PET/CT findings influenced the management of 8 (22%) patients - 3 with liver metastases, 3 with bone metastases, 1 with lymph node metastases and 1 by identifying the benign appearance of the pancreatic tumour.PET/CT achieves a significant diagnostic impact in detecting extrapancreatic metastatic disease. F18-fluorodeoxyglucose PET/CT appears to be useful in assessing suspicious pancreatic masses.

Published
2012

34. Are there anatomical barriers to laparoscopic donor nephrectomy?

Author

Catherine, Crane, Vincent W T, Lam, Abdulrahman, Alsakran, Arthur, Vasilaras, Howard, Lau, Brendan, Ryan, Henry C C, Pleass, and Richard D M, Allen

Subjects
Adult, Graft Rejection, Male, Tissue and Organ Procurement, Kaplan-Meier Estimate, Kidney, Nephrectomy, Risk Assessment, Renal Veins, Statistics, Nonparametric, Cohort Studies, Young Adult, Renal Artery, Living Donors, Humans, Aged, Retrospective Studies, Chi-Square Distribution, Anastomosis, Surgical, Graft Survival, Middle Aged, Kidney Transplantation, Survival Rate, Treatment Outcome, Female, Laparoscopy, Follow-Up Studies
Abstract

The aim of this study was to analyse the effect of the right donor kidney and multiple arteries, on donor and recipient outcomes in the era of laparoscopic live donor nephrectomy (LLDN).e retrospectively analysed the 200 donors and recipients who underwent a planned laparoscopic nephrectomy at two hospitals between September 1998 and December 2006. The impact of donor right kidney and multiple donor renal arteries on operative time, hospital stay, graft function, and donor and recipient complications were analysed.Of the total cohort (n=200), 140 (70%) were classified as Simple LLDN (left live donor kidney with single renal artery). The Complex LLDN group (n=60) contained all right-sided kidney (n=28) and left-sided kidneys with multiple renal arteries (n=32). Baseline characteristics, extraction time, conversion to open, length of admission, overall graft function and complication rates were similar between the simple and complex groups. The second warm ischaemic time in the Simple LLDN group was slightly shorter than the Complex LLDN group (32 versus 36 min P=0.016). The 1-month post-operative recipient serum creatinine level was lower in the Simple LLDN group when compared with the Complex LLDN group (117 versus 125 µmol/L P=0.025). There was no difference in post op dialysis, acute rejection within 3 months or graft survival between the Simple and Complex LLDN groups.Laparoscopic procurements of right kidneys and kidneys with multiple arteries were safe and yielded kidneys with excellent function comparable with those of laparoscopic left donor nephrectomy with single artery.

Published
2010

35. Evolution of pancreas transplant surgery

Author

Vincent W T, Lam, Henry C C, Pleass, Wayne, Hawthorne, and Richard D M, Allen

Subjects
Blood Glucose, Diabetes Mellitus, Type 1, Pancreatectomy, Tissue and Organ Procurement, Patient Selection, Humans, Pancreas Transplantation, Pancreas
Abstract

Type 1 diabetes mellitus is a chronic condition often leading to disabling complications including retinopathy, neuropathy and cardiovascular disease which can be modified by intensive treatment with insulin. Such treatment, however, is associated with a restrictive lifestyle and risk of hypoglycaemic morbidity and mortality.This review examines the role of pancreas transplantation in patients with Type 1 diabetes mellitus.Pancreas transplantation is currently the only proven option to achieve long-term insulin independence, resulting in an improvement or stabilization of those diabetic related complications. The hazards of pancreas transplantation as a major operation are well known. Balancing the risks of a surgical procedure, with the benefits of restoring normoglycaemia remains an important task for the pancreas transplant surgeon. Pancreas transplantation is not an emergency operation to treat poorly managed and non-compliant patients with debilitating complications. It is a highly specialized procedure which has evolved both in terms of the surgical technique, patient selection and assessment.Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis in patients with Type 1 diabetes mellitus.

Published
2010

36. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility

Author

Li, M. (M.), Luo, X.-J. (X.), Rietschel, M. (Marcella), Lewis, C.M. (Cathryn), Mattheisen, M. (Manuel), Müller-Myhsok, B. (B.), Jamain, S. (Stéphane), Leboyer, M. (Marion), Landén, M. (Mikael), Thompson, P.M. (Paul), Cichon, S. (Sven), Nöthen, M.M. (Markus), Schulze, T.G. (Thomas), Sullivan, P. (Patrick), Bergen, S.E. (Sarah), Donohoe, D.J. (Dennis), Morris, D.W. (Derek W), Hargreaves, A. (A.), Gill, M. (Michael), Corvin, A. (Aiden), Hultman, C.M. (Christina), Toga, A.W. (Arthur), Shi, L. (L.), Lin, Q. (Q.), Shi, H. (Hong), Gan, L. (L.), Meyer-Lindenberg, A., Czamara, D. (Darina), Henry, C. (C.), Etain, B. (Bruno), Bis, J.C. (Joshua), Ikram, M.A. (Arfan), Fornage, M. (Myriam), Debette, S. (Stéphanie), Launer, L.J. (Lenore), Seshadri, S. (Sudha), Erk, S., Walter, H.J. (Henrik), Heinz, J. (Judith), Bellivier, F. (Frank), Stein, J.L., Medland, S.E. (Sarah), Arias-Vásquez, A. (Alejandro), Hibar, D.P. (Derrek), Franke, B. (Barbara), Martin, N.G. (Nicholas), Wright, M.J. (Margaret), Su, B. (B.), Li, M. (M.), Luo, X.-J. (X.), Rietschel, M. (Marcella), Lewis, C.M. (Cathryn), Mattheisen, M. (Manuel), Müller-Myhsok, B. (B.), Jamain, S. (Stéphane), Leboyer, M. (Marion), Landén, M. (Mikael), Thompson, P.M. (Paul), Cichon, S. (Sven), Nöthen, M.M. (Markus), Schulze, T.G. (Thomas), Sullivan, P. (Patrick), Bergen, S.E. (Sarah), Donohoe, D.J. (Dennis), Morris, D.W. (Derek W), Hargreaves, A. (A.), Gill, M. (Michael), Corvin, A. (Aiden), Hultman, C.M. (Christina), Toga, A.W. (Arthur), Shi, L. (L.), Lin, Q. (Q.), Shi, H. (Hong), Gan, L. (L.), Meyer-Lindenberg, A., Czamara, D. (Darina), Henry, C. (C.), Etain, B. (Bruno), Bis, J.C. (Joshua), Ikram, M.A. (Arfan), Fornage, M. (Myriam), Debette, S. (Stéphanie), Launer, L.J. (Lenore), Seshadri, S. (Sudha), Erk, S., Walter, H.J. (Henrik), Heinz, J. (Judith), Bellivier, F. (Frank), Stein, J.L., Medland, S.E. (Sarah), Arias-Vásquez, A. (Alejandro), Hibar, D.P. (Derrek), Franke, B. (Barbara), Martin, N.G. (Nicholas), Wright, M.J. (Margaret), and Su, B. (B.)

Abstract

Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64 888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785A, P=6.32 × 10 -5, odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, including hippocampal volume, hippocampal function and cognitive performance. Our results showed that the risk SNPs were significantly associated with hippocampal volume and hippocampal function, with the risk alleles showing a decreased hippocampal volume and diminished activation of the left hippocampus, adding further evidence for their involvement in BD susceptibility. We also found the risk SNPs were strongly associated with CREB1 expression in lymphoblastoid cells (P<0.005) and the prefrontal cortex (P<1.0 × 10 -6). Remarkably, population genetic analysis indicated that CREB1 displayed striking differences in allele frequencies between continental populations, and the risk alleles were completely absent in East Asian populations. We demonstrated that the regional prevalence of the CREB1 risk alleles in Europeans is likely caused by genetic hitchhiking due to natural selection acting on a nearby gene. Our results suggest that differential population histories due to natural selection on regional populations may lead to genetic heterogeneity of susceptibility to complex diseases, such as BD, and explain inconsistencies in detecting the genetic markers of these diseases among differe

Published
2014
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37. Human activities recognition by head movement using partial recurrent neural network

Author

Liyanage C. De Silva, Kui Jia, and Henry C. C. Tan

Subjects
Artificial neural network, Color image, Head (linguistics), Computer science, business.industry, Feature extraction, Pattern recognition, Recurrent neural network, Connectionism, Pattern recognition (psychology), Computer vision, Artificial intelligence, Hidden Markov model, business
Abstract

Traditionally, human activities recognition has been achieved mainly by the statistical pattern recognition methods or the Hidden Markov Model (HMM). In this paper, we propose a novel use of the connectionist approach for the recognition of ten simple human activities: walking, sitting down, getting up, squatting down and standing up, in both lateral and frontal views, in an office environment. By means of tracking the head movement of the subjects over consecutive frames from a database of different color image sequences, and incorporating the Elman model of the partial recurrent neural network (RNN) that learns the sequential patterns of relative change of the head location in the images, the proposed system is able to robustly classify all the ten activities performed by unseen subjects from both sexes, of different race and physique, with a recognition rate as high as 92.5%. This demonstrates the potential of employing partial RNN to recognize complex activities in the increasingly popular human-activities-based applications.

Published
2003

38. Aortoiliac aneurysm with arteriocaval fistula treated by a bifurcated endovascular stent-graft

Author

Carolyn J. Beveridge, Henry C. C. Pleass, John Chamberlain, Michael G. Wyatt, and John D. G. Rose

Subjects
Male, Arteriovenous Fistula, Angiography, Digital Subtraction, Humans, Radiology, Nuclear Medicine and imaging, Stents, Venae Cavae, Cardiology and Cardiovascular Medicine, Tomography, X-Ray Computed, Iliac Artery, Aged, Aortic Aneurysm
Abstract

A 71-year-old patient with high-output cardiac failure was found to have an aneurysmal distal aorta with evidence of an arteriocaval fistula on ultrasound scanning. CT demonstrated an aneurysm of the distal aorta and right common iliac artery and an intraarterial digital subtraction angiogram confirmed an arteriocaval fistula. In view of the patient's cardiac failure and general condition an endovascular stent was considered. The right internal iliac artery was occluded with Tungsten coils prior to the insertion of a bifurcated stent-graft. This resulted in total occlusion of the aneurysm and obliteration of the arteriocaval fistula. To our knowledge such a case has not been previously reported.

Published
1998

46. Re: Aortoiliac aneurysm with arteriocaval fistula treated by a bifurcated endovascular stent-graft

Author

Henry C. C. Pleass, Carolyn J. Beveridge, M.G. Wyatt, John Rose, Richard W. J. Hartley, and John Chamberlain

Subjects
medicine.medical_specialty, Aorta, Vascular disease, business.industry, Fistula, medicine.medical_treatment, Stent, Right Common Iliac Artery, medicine.disease, Internal iliac artery, Abdominal aortic aneurysm, Surgery, Aneurysm, medicine.artery, cardiovascular system, medicine, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Radiology, Cardiology and Cardiovascular Medicine, business
Abstract

A 71-year-old patient with high-output cardiac failure was found to have an aneurysmal distal aorta with evidence of an arteriocaval fistula on ultrasound scanning. CT demonstrated an aneurysm of the distal aorta and right common iliac artery and an intraarterial digital subtraction angiogram confirmed an arteriocaval fistula. In view of the patient’s cardiac failure and general condition an endovascular stent was considered. The right internal iliac artery was occluded with Tungsten coils prior to the insertion of a bifurcated stent-graft. This resulted in total occlusion of the aneurysm and obliteration of the arteriocaval fistula. To our knolwedge such a case has not been previously reported.

Published
1999

49. Hydro Project Formulation: Results in the Southeast

Author

Clement P. Lindner and Henry C. C. Weinkauff

Subjects
Engineering, business.industry, Control (management), General Engineering, Water supply, Legislation, Environmental economics, Civil engineering, Water resources, Flood control, Resource (project management), Value engineering, business, Recreation
Abstract

The Congress has directed that water resource development plans and projects be comprehensive in that adequate consideration be given to all uses that are of value to the public. Besides power, flood control, navigation, and irrigation, statutory support is specifically mentioned for recreation, fish and wildlife, water supply, and water quality control. The general principle applied is that each use should be developed so the difference between benefits and cost is maximized, although in applying this principle it is recognized that latitude must be exercised to allow for benefits or effects of public concern that cannot be appraised in monetary terms and for choice between conflicting uses. A major feature of the paper concerns the concepts involved in hydro power project formulation. To determine whether power facilities should be included in a water resource project, tests are applied to ascertain economic and financial feasibility. The application of these concepts or corresponding ones used earlier has resulted in the authorization of power facilities in the southeast the capacity of which totals 1,647,000 kw with an average annual output of 3,875,000,000.

Published
1966

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