37 results on '"Henningsson, Susanne"'
Search Results
2. A randomized placebo-controlled intranasal oxytocin study on first impressions and reactions to social rejection
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Henningsson, Susanne, Leknes, Siri, Asperholm, Martin, Eikemo, Marie, and Westberg, Lars
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- 2021
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3. Serotonergic neurotransmission in emotional processing: New evidence from long-term recreational poly-drug ecstasy use
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Laursen, Helle Ruff, Henningsson, Susanne, Macoveanu, Julian, Jernigan, Terry L, Siebner, Hartwig R, Holst, Klaus K, Skimminge, Arnold, Knudsen, Gitte M, Ramsoy, Thomas Z, and Erritzoe, David
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Behavioral and Social Science ,Substance Misuse ,Clinical Research ,Basic Behavioral and Social Science ,Mental Health ,Neurosciences ,Mental health ,Adult ,Amygdala ,Brain ,Case-Control Studies ,Cross-Sectional Studies ,Emotions ,Female ,Humans ,Magnetic Resonance Imaging ,Male ,N-Methyl-3 ,4-methylenedioxyamphetamine ,Positron-Emission Tomography ,Serotonin ,Serotonin Plasma Membrane Transport Proteins ,Synaptic Transmission ,Young Adult ,MDMA ,ecstasy ,serotonin ,fMRI ,emotion ,amygdala ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biomedical and clinical sciences ,Health sciences - Abstract
The brain's serotonergic system plays a crucial role in the processing of emotional stimuli, and several studies have shown that a reduced serotonergic neurotransmission is associated with an increase in amygdala activity during emotional face processing. Prolonged recreational use of ecstasy (3,4-methylene-dioxymethamphetamine [MDMA]) induces alterations in serotonergic neurotransmission that are comparable to those observed in a depleted state. In this functional magnetic resonance imaging (fMRI) study, we investigated the responsiveness of the amygdala to emotional face stimuli in recreational ecstasy users as a model of long-term serotonin depletion. Fourteen ecstasy users and 12 non-using controls underwent fMRI to measure the regional neural activity elicited in the amygdala by male or female faces expressing anger, disgust, fear, sadness, or no emotion. During fMRI, participants made a sex judgement on each face stimulus. Positron emission tomography with 11C-DASB was additionally performed to assess serotonin transporter (SERT) binding in the brain. In the ecstasy users, SERT binding correlated negatively with amygdala activity, and accumulated lifetime intake of ecstasy tablets was associated with an increase in amygdala activity during angry face processing. Conversely, time since the last ecstasy intake was associated with a trend toward a decrease in amygdala activity during angry and sad face processing. These results indicate that the effects of long-term serotonin depletion resulting from ecstasy use are dose-dependent, affecting the functional neural basis of emotional face processing.
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- 2016
4. The Center for Integrated Molecular Brain Imaging (Cimbi) database
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Knudsen, Gitte M, Jensen, Peter S, Erritzoe, David, Baaré, William FC, Ettrup, Anders, Fisher, Patrick M, Gillings, Nic, Hansen, Hanne D, Hansen, Lars Kai, Hasselbalch, Steen G, Henningsson, Susanne, Herth, Matthias M, Holst, Klaus K, Iversen, Pernille, Kessing, Lars V, Macoveanu, Julian, Madsen, Kathrine Skak, Mortensen, Erik L, Nielsen, Finn Årup, Paulson, Olaf B, Siebner, Hartwig R, Stenbæk, Dea S, Svarer, Claus, Jernigan, Terry L, Strother, Stephen C, and Frokjaer, Vibe G
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Depression ,Neurosciences ,Brain Disorders ,Mental Health ,Biomedical Imaging ,Neurological ,Mental health ,Good Health and Well Being ,Biological Specimen Banks ,Biomarkers ,Computer Security ,Databases ,Factual ,Healthy Volunteers ,Humans ,Information Dissemination ,Magnetic Resonance Imaging ,Mental Disorders ,Molecular Imaging ,Neuroimaging ,Neuropsychological Tests ,Quality Control ,Receptors ,Serotonin ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Abstract
We here describe a multimodality neuroimaging containing data from healthy volunteers and patients, acquired within the Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) in Copenhagen, Denmark. The data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 and the 5-HT transporter (5-HTT), but can easily serve other purposes. The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies. The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e.g., major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank.
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- 2016
5. Amygdala signals subjective appetitiveness and aversiveness of mixed gambles
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Gelskov, Sofie V., Henningsson, Susanne, Madsen, Kristoffer H., Siebner, Hartwig R., and Ramsøy, Thomas Z.
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- 2015
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6. Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2
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Hovey, Daniel, Henningsson, Susanne, Cortes, Diana S, Bänziger, Tanja, Zettergren, Anna, Melke, Jonas, Fischer, Håkan, Laukka, Petri, and Westberg, Lars
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- 2018
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7. Genetic Variation in the Vasopressin Receptor 1a Gene (AVPR1A) Associates with Pair-Bonding Behavior in Humans
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Walum, Hasse, Westberg, Lars, Henningsson, Susanne, Neiderhiser, Jenae M., Reiss, David, Igl, Wilmar, Ganiban, Jody M., Spotts, Erica L., Pedersen, Nancy L., Eriksson, Elias, and Lichtenstein, Paul
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- 2008
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8. Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight
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Bah, Jessica, Westberg, Lars, Baghaei, Fariba, Henningsson, Susanne, Rosmond, Roland, Melke, Jonas, Holm, Göran, and Eriksson, Elias
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- 2010
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9. Possible association between the androgen receptor gene and autism spectrum disorder
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Henningsson, Susanne, Jonsson, Lina, Ljunggren, Elin, Westberg, Lars, Gillberg, Carina, Råstam, Maria, Anckarsäter, Henrik, Nygren, Gudrun, Landén, Mikael, Thuresson, Kent, Betancur, Catalina, Leboyer, Marion, Gillberg, Christopher, Eriksson, Elias, and Melke, Jonas
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- 2009
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10. Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters
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Bah, Jessica, Lindström, Mats, Westberg, Lars, Mannerås, Louise, Ryding, Erik, Henningsson, Susanne, Melke, Jonas, Rosén, Ingmar, Träskman-Bendz, Lil, and Eriksson, Elias
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- 2008
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11. Influence of androgen receptor repeat polymorphisms on personality traits in men
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Westberg, Lars, Henningsson, Susanne, Landen, Mikael, Annerbrink, Kristina, Melke, Jonas, Nilsson, Staffan, Rosmond, Roland, Holm, Goran, Anckarsater, Henrik, and Eriksson, Elias
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Androgens -- Health aspects ,Personality -- Genetic aspects ,Genetic polymorphisms -- Research ,Men -- Health aspects ,Men -- Genetic aspects ,Men -- Psychological aspects - Abstract
Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations: Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion: Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men. Contexte : On a attribue de l'importance a la testosterone pour divers aspects du comportement. Notre etude visait a etudier l'influence possible de 2 polymorphismes fonctionnels de la terminaison amine du recepteur de l'androgene sur les traits de personnalite chez l'homme. Methodes : Nous avons evalue et genotype 141 hommes nes en 1944 recrutes dans la population generale. Nous avons utilise 2 instruments differents : les echelles de la personnalite de Karolinska et le questionnaire sur le temperament et le caractere. Pour la repetition, nous avons evalue de la meme facon 63 hommes recrutes dans un groupe d'etude en psychiatrie medico-legale. Resultats : Dans l'echantillon recrute au sein de la population, on a etabli un lien entre la longueur des repetitions du recepteur de l'androgene et les traits nevrotiques, l'extraversion et l'autotranscendance. On a retrouve le lien avec l'extraversion dans l'echantillon d'origine independante. Limites : La taille de nos 2 echantillons etait differente : l'echantillon 1 etait de taille moderee et l'echantillon 2, de taille modeste. En outre, l'homogeneite de l'echantillon 1 a probablement ameliore notre capacite de detecter des liens significatifs entre le genotype et le phenotype. Conclusion : Nos resultats indiquent que les polymorphismes repetes dans le gene recepteur de l'androgene peuvent avoir une influence sur des traits de personnalite chez l'homme., Introduction Testosterone influences the structure and function of the brain, both during development and in the adult organism, and is a key factor for the sexual differentiation of this organ. [...]
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- 2009
12. Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder
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Furmark, Tomas, Henningsson, Susanne, Appel, Lieuwe, Ahs, Fredrik, Linnman, Clas, Pissiota, Anna, Faria, Vanda, Oreland, Lars, Bani, Massimo, Pich, Emilio Merlo, Eriksson, Elias, and Fredrikson, Mats
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Social phobia -- Physiological aspects ,Social phobia -- Psychological aspects ,Amygdala (Brain) -- Properties ,Human information processing -- Research - Abstract
Background: Although the amygdala is thought to be a crucial brain region for negative affect, neuroimaging studies do not always show enhanced amygdala response to aversive stimuli in patients with anxiety disorders. Serotonin (5-HT)-related genotypes may contribute to interindividual variability in amygdala responsiveness. The short (s) allele of the 5-HT transporter linked polymorphic region (5-HTTLPR) and the T variant of the G-703T polymorphism in the tryptophan hydroxylase-2 (TPH2) gene have previously been associated with amygdala hyperresponsivity to negative faces in healthy controls. We investigated the influence of these polymorphisms on amygdala responsiveness to angry faces in patients with social anxiety disorder (SAD) compared with healthy controls. Methods: We used positron emission tomography with oxygen 15-labelled water to assess regional cerebral blood flow in 34 patients with SAD and 18 controls who viewed photographs of angry and neutral faces presented in counterbalanced order. We genotyped all participants with respect to the 5-HTTLPR and TPH2 polymorphisms. Results: Patients with SAD and controls had increased left amygdala activation in response to angry compared with neutral faces. Genotype but not diagnosis explained a significant portion of the variance in amygdala responsiveness, the response being more pronounced in carriers of s and/or T alleles. Limitations: Our analyses were limited owing to the small sample and the fact that we were unable to match participants on genotype before enrolment. In addition, other imaging techniques not used in our study may have revealed additional effects of emotional stimuli. Conclusion: Amygdala responsiveness to angry faces was more strongly related to serotonergic polymorphisms than to diagnosis of SAD. Emotion activation studies comparing amygdala excitability in patient and control groups could benefit from taking variation in 5-HT-related genes into account. Contexte: Meme si l'on considere l'amygdale comme une region du cerveau cruciale pour l'affect negatif, les epreuves de neuroimagerie ne revelent pas toujours un rehaussement de la reactivite amygdalienne aux stimuli aversifs chez les patients souffrant de troubles anxieux. Les genotypes lies a la serotonine (5-HT) pourraient contribuer a la variabilite interindividuelle de la reponse amygdalienne. L'allele (s) court du gene polymorphe 5-HTTLPR (serotonin-transporter-linked polymorphic region), un transporteur de la 5-HT, et la variante T du polymorphisme G-703T du gene TPH2 (tryptophan hydroxylase-2) ont ete associes anterieurement a une hyperreactivite amygdalienne aux visages exprimant une emotion negative chez des temoins en bonne sante. Nous avons voulu mesurer l'influence de ces polymorphismes sur la reactivite amygdalienne aux visages exprimant la colere chez des patients atteints de phobie sociale, comparativement a des temoins en bonne sante. Methodes : Nous avons utilise la tomographie par emission de positrons avec de l'eau radioactive marquee a l'oxygene 15 pour mesurer le debit sanguin cerebral regional chez 34 patients souffrant de phobie sociale et 18 temoins a qui l'on presentait des photographies de visages en colere ou neutres en sequence contrebalancees. Nous avons etabli le genotype de tous les participants pour ce qui est des polymorphismes 5-HTTLPR et TPH2. Resultats : Les patients souffrant de phobie sociale et les temoins ont presente une activation amygdalienne gauche accrue en reponse aux visages en colere, par rapport aux visages neutres. Il a ete possible d'expliquer une portion significative de la variance de la reactivite amygdalienne par le genotype, mais non par le diagnostic, la reponse ayant ete plus prononcee chez les porteurs des alleles s ou T. Limites : Nos analyses ont ete limitees en raison du petit echantillon et du fait que nous n'ayons pas pu assortir les participants selon leurs genotypes avant leur inscription a l'etude. De plus, d'autres techniques d'imagerie, non utilisees lors de notre etude, auraient pu reveler certains effets additionnels des stimuli emotionnels. Conclusion : La reactivite amygdalienne aux visages exprimant la colere a ete plus intimement liee aux polymorphismes serotoninergiques qu'au diagnostic de phobie sociale. Les etudes d'activation des emotions comparant l'excitabilite de l'amygdale chez des groupes de patients et de temoins pourraient utiliser avantageusement les variations des genes lies a la 5-HT., Introduction The amygdala has long been associated with fear reactions and detection of danger signals. (1) Studies in animals and humans have confirmed that the amygdala is a critical structure [...]
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- 2009
13. Sex steroid-related genes and male-to-female transsexualism
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Henningsson, Susanne, Westberg, Lars, Nilsson, Staffan, Lundström, Bengt, Ekselius, Lisa, Bodlund, Owe, Lindström, Eva, Hellstrand, Monika, Rosmond, Roland, Eriksson, Elias, and Landén, Mikael
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- 2005
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14. The role of identification for the motivational force of moral judgments
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Henningsson, Susanne
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Philosophy ,Filosofi ,judgment internalism ,motivation ,self-consistency ,externalism ,motivational internalism ,identification ,volitional necessity - Abstract
What is the relationship between judging something as good and being motivated to acton this judgment? Motivational internalism is the thesis that there is a necessaryconnection between moral judgments and motivation. Externalists typically believe that ajudgment-independent desire is needed for the moral judgment to be motivating. Tobridge the gap between internalism and externalism, a few philosophers have appealed totheories of identification-based moral judgments. This implies that although moraljudgments may not be necessarily motivating in general, it could be possible to define acertain kind of identification-based moral judgment that is necessarily motivating. HereinI will examine the role identification plays for moral motivation. I will first analyse anargument that uses an identification-incompatible moral judgment to show thatinternalism is false. I will argue that this argument is unconvincing and that identificationdoes not preclude identification-incompatible moral judgments from being motivating.The identification-based argument hence does not support that internalism is false.Second, I will argue that identification can provide the motivational force needed to makecertain identity-based moral judgments necessarily motivating. This identification-basedaccount does however, I will argue, not support internalism. Despite presenting a kind ofmoral judgment that is necessarily motivating, it is an externalist account of theconnection between moral judgments and motivation since a judgment-independentdesire is a necessary source of its motivational force.
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- 2019
15. Association between serum levels of C-reactive protein and personality traits in women
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Anckarsäter Henrik, Landén Mikael, Holm Göran, Rosmond Roland, Baghaei Fariba, Henningsson Susanne, and Ekman Agneta
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background While low-grade inflammation has consistently been observed in subjects with depression, studies on the possible relationship between inflammation and other aspects of brain function are as yet sparse. In this study, we aimed to investigate the possible association between serum levels of the inflammation marker C-reactive protein (CRP) and personality traits. Methods In this study, serum levels of high-sensitivity CRP were determined by ELISA in a population of 270 42-year-old women recruited from the population registry who had been assessed using the Temperament and Character Inventory. Self-reported previous or ongoing depression was also recorded. Unpaired two-tailed t-tests were used for comparison between two groups and correlations were evaluated by the calculation of Pearson's r-coefficient. Results The temperament trait harm avoidance was positively (r = 0.227, p < 0.05) and the character trait self-directedness was negatively (r = -0.261, p < 0.01) associated with serum levels of CRP (p-values corrected for multiple comparisons). The correlations between the personality traits and CRP were observed also after exclusion of subjects reporting ongoing depression (n = 26). Whereas women reporting ongoing depression showed significantly increased levels of CRP as compared to non-depressed women (n = 155), women reporting a history of depression displayed no significant difference in CRP levels as compared to women that reported that they had never been depressed. Conclusion Serum levels of CRP in women was found to be associated with the personality traits harm avoidance and self-directedness. In addition, moderately elevated levels may be a state dependent marker of depression.
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- 2008
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16. Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2
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Hovey, Daniel, primary, Henningsson, Susanne, additional, Cortes, Diana S, additional, Bänziger, Tanja, additional, Zettergren, Anna, additional, Melke, Jonas, additional, Fischer, Håkan, additional, Laukka, Petri, additional, and Westberg, Lars, additional
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- 2017
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17. Variation in the Oxytocin Receptor Gene Is Associated with Face Recognition and its Neural Correlates
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Westberg, Lars, Henningsson, Susanne, Zettergren, Anna, Svärd, Joakim, Hovey, Daniel, Lin, Tian, Ebner, Natalie C., and Fischer, Håkan
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oxytocin ,OXTR ,social cognition ,Neuroscience ,face recognition ,polymorphism - Abstract
The ability to recognize faces is crucial for daily social interactions. Recent studies suggest that intranasal oxytocin administration improves social recognition in humans. Oxytocin signaling in the amygdala plays an essential role for social recognition in mice, and oxytocin administration has been shown to influence amygdala activity in humans. It is therefore possible that the effects of oxytocin on human social recognition depend on mechanisms that take place in the amygdala—a central region for memory processing also in humans. Variation in the gene encoding the oxytocin receptor (OXTR) has been associated with several aspects of social behavior. The present study examined the potential associations between nine OXTR polymorphisms, distributed across the gene, and the ability to recognize faces, as well as face-elicited amygdala activity measured by functional magnetic resonance imaging (fMRI) during incidental encoding of faces. The OXTR 3′ polymorphism rs7632287, previously related to social bonding behavior and autism risk, was associated with participants’ ability to recognize faces. Carriers of the GA genotype, associated with enhanced memory, displayed higher amygdala activity during face encoding compared to carriers of the GG genotype. In line with work in rodents, these findings suggest that, in humans, naturally occurring endogenous modulation of OXTR function affects social recognition through an amygdala-dependent mechanism. These findings contribute to the understanding of how oxytocin regulates human social behaviors.
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- 2016
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18. Pharmacologically Induced Sex Hormone Fluctuation Effects on Resting-State Functional Connectivity in a Risk Model for Depression: A Randomized Trial
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Fisher, Patrick MacDonald, primary, Larsen, Camilla Borgsted, additional, Beliveau, Vincent, additional, Henningsson, Susanne, additional, Pinborg, Anja, additional, Holst, Klaus Kähler, additional, Jensen, Peter Steen, additional, Svarer, Claus, additional, Siebner, Hartwig Roman, additional, Knudsen, Gitte Moos, additional, and Frokjaer, Vibe Gedsoe, additional
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- 2016
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19. Social memory associated with estrogen receptor polymorphisms in women
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Karlsson, Sara, primary, Henningsson, Susanne, additional, Hovey, Daniel, additional, Zettergren, Anna, additional, Jonsson, Lina, additional, Cortes, Diana S., additional, Melke, Jonas, additional, Laukka, Petri, additional, Fischer, Håkan, additional, and Westberg, Lars, additional
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- 2016
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20. Association between polymorphisms in NOS3 and KCNH2 and social memory
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Henningsson, Susanne, primary, Zettergren, Anna, additional, Hovey, Daniel, additional, Jonsson, Lina, additional, Svärd, Joakim, additional, Cortes, Diana S., additional, Melke, Jonas, additional, Ebner, Natalie C., additional, Laukka, Petri, additional, Fischer, Håkan, additional, and Westberg, Lars, additional
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- 2015
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21. Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study
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Frokjaer, Vibe Gedsoe, primary, Pinborg, Anja, additional, Holst, Klaus Kähler, additional, Overgaard, Agnete, additional, Henningsson, Susanne, additional, Heede, Maria, additional, Larsen, Elisabeth Clare, additional, Jensen, Peter Steen, additional, Agn, Mikael, additional, Nielsen, Anna Pors, additional, Stenbæk, Dea Siggaard, additional, da Cunha-Bang, Sophie, additional, Lehel, Szabolcs, additional, Siebner, Hartwig Roman, additional, Mikkelsen, Jens Damsgaard, additional, Svarer, Claus, additional, and Knudsen, Gitte Moos, additional
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- 2015
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22. Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward
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Macoveanu, Julian, primary, Henningsson, Susanne, additional, Pinborg, Anja, additional, Jensen, Peter, additional, Knudsen, Gitte M, additional, Frokjaer, Vibe G, additional, and Siebner, Hartwig R, additional
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- 2015
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23. Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy
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Laursen, Helle Ruff, primary, Siebner, Hartwig Roman, additional, Haren, Tina, additional, Madsen, Kristoffer, additional, Grønlund, Rikke, additional, Hulme, Oliver, additional, and Henningsson, Susanne, additional
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- 2014
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24. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism
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Henningsson, Susanne
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transsexualism ,5-HT3 ,autism ,amygdala ,5-HTTLPR ,anxiety ,serotonin ,life events ,personality ,androgen receptor ,TPH2 ,depression ,sex steroids ,genetics ,premenstrual dysphoric disorder ,emotional perception ,estrogen receptor ,gene-gene interaction ,social phobia - Abstract
Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. The specific aims of this thesis were: (i) to investigate the possible influence of serotonin-related genetic variation on the neural correlates of anxiety, and on mood- and anxiety-related phenotypes, including premenstrual dysphoric disorder (PMDD), depression and anxiety-related personality traits, (ii) to investigate the possible influence of sex steroid-related genetic variation on personality, autism spectrum disorder and transsexualism, and (iii) to try to ameliorate the chance of detecting effects of combinations of genetic variations by restricting the statistical analysis to particular patterns. Results: (i) The serotonin transporter (5-HTT) linked polymorphic region (5-HTTLPR) and a polymorphism in an important enzyme for serotonin synthesis (tryptophan hydroxylase 2; TPH2) were associated with amygdala response during presentation of angry faces in subjects with social phobia and controls. (ii) The same polymorphisms were associated with response to placebo and also with placebo-induced changes in amygdala activity during public speaking in subjects with social phobia. (iii) In men, genetic variation in the neurotrophic factor BDNF, which is closely related to the serotonergic system, was associated with the amount of serotonin transporter in the brain. (iv) Polymorphisms in genes that encode proteins important for the development of the serotonergic system (GATA2), for serotonin synthesis (TPH2) and for serotonergic transmission (5-HT3B) were associated with PMDD. (v) The 5-HTTLPR was shown to influence reports of controllable stressful life events in combination with the BDNF Val66Met polymorphism or anxiety-related personality traits in non-depressed men. (vi) Variants that may increase the function of the androgen receptor were associated with extraversion and spiritual acceptance in men. (vii) A variant that is associated with increased androgen receptor function was more common in women with autism spectrum disorder than in controls. (viii) The same androgen receptor polymorphism was associated with transsexualism in combination with polymorphisms in the genes encoding the estrogen receptor β or the testosterone-converting aromatase enzyme. (ix) A method that restricts the search for genetic combinations to monotone effect patterns was shown to increase the probability of finding gene-gene effects. Conclusions: The results support the notion that variation in genes that encode serotonin-related and sex steroid-related proteins are of importance for the psychiatric traits studied in this thesis.
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- 2008
25. Pharmacologically Induced Sex Hormone Fluctuation Effects on Resting-State Functional Connectivity in a Risk Model for Depression: A Randomized Trial
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Fisher, Patrick MacDonald, Larsen, Camilla Borgsted, Beliveau, Vincent, Henningsson, Susanne, Pinborg, Anja, Holst, Klaus Kähler, Jensen, Peter Steen, Svarer, Claus, Siebner, Hartwig Roman, Knudsen, Gitte Moos, and Frokjaer, Vibe Gedsoe
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Women are at relatively greater lifetime risk for depression than men. This elevated risk in women is partly due to heightened risk during time periods characterized by marked fluctuations in sex hormones, including postpartum and perimenopausal periods. How sex hormone fluctuations contribute to heightened risk is not fully understood but may involve intrinsic functional connectivity. We induced a biphasic ovarian sex hormone fluctuation using the gonadotropin-releasing hormone agonist (GnRHa) goserelin to determine, with a randomized placebo-controlled design, intervention effects on or GnRHa-provoked depressive symptoms associations with change in resting-state functional connectivity (rs-FC) in 58 healthy women for six seeds (amygdala, hippocampus, anterior cingulate cortex, dorsal raphe, median raphe, and posterior cingulate cortex). GnRHa intervention did not significantly affect rs-FC in any seeds. Considering the GnRHa group only, the emergence of depressive symptoms following intervention was positively associated with amygdala-right temporal cortex and negatively associated with hippocampus–cingulate rs-FC. A test for mediation suggested that rs-FC changes in these networks marginally mediated the association between decrease in estradiol and increase in depressive symptoms in the GnRHa group (p=0.07). Our findings provide novel evidence-linking changes in rs-FC networks, the emergence of depressive symptoms and sex hormone fluctuations. Notably, we observed evidence that changes in rs-FC may represent a key neurobiological intermediary between molecular changes induced by hormone fluctuations and the emergence of depressive symptoms. Taken together, our findings indicate that sex hormone fluctuations may contribute to heightened risk for developing depressive symptoms by affecting intrinsic functional connectivity of key limbic brain structures.
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- 2017
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26. Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans
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Borg, Jacqueline, primary, Henningsson, Susanne, additional, Saijo, Tomoyuki, additional, Inoue, Makoto, additional, Bah, Jessica, additional, Westberg, Lars, additional, Lundberg, Johan, additional, Jovanovic, Hristina, additional, Andrée, Bengt, additional, Nordstrom, Anna-Lena, additional, Halldin, Christer, additional, Eriksson, Elias, additional, and Farde, Lars, additional
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- 2009
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27. Association between the AGTR1 polymorphism +1166A>C and serum levels of high-sensitivity C-reactive protein
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Suchankova, Petra, primary, Henningsson, Susanne, additional, Olsson, Marie, additional, Baghaei, Fariba, additional, Rosmond, Roland, additional, Holm, Göran, additional, Eriksson, Elias, additional, and Ekman, Agneta, additional
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- 2009
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28. Association between serum levels of C-reactive protein and personality traits in women
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Henningsson, Susanne, primary, Baghaei, Fariba, additional, Rosmond, Roland, additional, Holm, Göran, additional, Landén, Mikael, additional, Anckarsäter, Henrik, additional, and Ekman, Agneta, additional
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- 2008
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29. Detecting Two-Locus Gene-Gene Effects Using Monotonisation of the Penetrance Matrix
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Henningsson, Susanne, primary and Nilsson, Staffan I, additional
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- 2008
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30. Absence of the Arg441His polymorphism in the tryptophan hydroxylase 2 gene in adults with anxiety disorders and depression
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Henningsson, Susanne, primary, Annerbrink, Kristina, additional, Olsson, Marie, additional, Allgulander, Christer, additional, Andersch, Sven, additional, Sjödin, Ingemar, additional, Gustafson, Deborah, additional, Skoog, Ingmar, additional, Eriksson, Elias, additional, and Westberg, Lars, additional
- Published
- 2007
- Full Text
- View/download PDF
31. Interleukin-6 Gene Polymorphism −174G/C Influences Plasma Lipid Levels in Women*
- Author
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Henningsson, Susanne, primary, Håkansson, Anna, additional, Westberg, Lars, additional, Baghaei, Fariba, additional, Rosmond, Roland, additional, Holm, Göran, additional, Ekman, Agneta, additional, Nissbrandt, Hans, additional, and Eriksson, Elias, additional
- Published
- 2006
- Full Text
- View/download PDF
32. Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward
- Author
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Macoveanu, Julian, Henningsson, Susanne, Pinborg, Anja, Jensen, Peter, Knudsen, Gitte M, Frokjaer, Vibe G, and Siebner, Hartwig R
- Abstract
Mood disorders are twice as frequent in women than in men. Risk mechanisms for major depression include adverse responses to acute changes in sex-steroid hormone levels, eg, postpartum in women. Such adverse responses may involve an altered processing of rewards. Here, we examine how women’s vulnerability for mood disorders is linked to sex-steroid dynamics by investigating the effects of a pharmacologically induced fluctuation in ovarian sex steroids on the brain response to monetary rewards. In a double-blinded placebo controlled study, healthy women were randomized to receive either placebo or the gonadotropin-releasing hormone agonist (GnRHa) goserelin, which causes a net decrease in sex-steroid levels. Fifty-eight women performed a gambling task while undergoing functional MRI at baseline, during the mid-follicular phase, and again following the intervention. The gambling task enabled us to map regional brain activity related to the magnitude of risk during choice and to monetary reward. The GnRHa intervention caused a net reduction in ovarian sex steroids (estradiol and testosterone) and increased depression symptoms. Compared with placebo, GnRHa reduced amygdala’s reactivity to high monetary rewards. There was a positive association between the individual changes in testosterone and changes in bilateral insula response to monetary rewards. Our data provide evidence for the involvement of sex-steroid hormones in reward processing. A blunted amygdala response to rewarding stimuli following a rapid decline in sex-steroid hormones may reflect a reduced engagement in positive experiences. Abnormal reward processing may constitute a neurobiological mechanism by which sex-steroid fluctuations provoke mood disorders in susceptible women.
- Published
- 2016
- Full Text
- View/download PDF
33. Genetic Variation in Brain-Derived Neurotrophic Factor Is Associated with Serotonin Transporter but Not Serotonin-1A Receptor Availability in Men
- Author
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Henningsson, Susanne, Borg, Jacqueline, Lundberg, Johan, Bah, Jessica, Lindström, Mats, Ryding, Erik, Jovanovic, Hristina, Saijo, Tomoyuki, Inoue, Makoto, Rosén, Ingmar, Träskman-Bendz, Lil, Farde, Lars, and Eriksson, Elias
- Subjects
- *
HUMAN genetic variation , *NEURAL physiology , *SEROTONIN , *NEURAL receptors , *MEN'S mental health , *POSITRON emission tomography , *SEROTONINERGIC mechanisms , *GENE expression - Abstract
Background: The serotonergic system, including the serotonin transporter (5-HTT), which is the target of many antidepressants, seems to be influenced by brain-derived neurotrophic factor (BDNF). Methods: Positron emission tomography (PET) was used to address, in 25 and 53 healthy volunteers, respectively, the possible association between six polymorphisms in the gene encoding BDNF and the availability of two proteins expressed by serotonergic neurons: the 5-HTT, measured with the radioligand [11C]MADAM, and the serotonin-1A (5-HT1A) receptor, measured with [11C]WAY-100635. Results: Several single nucleotide polymorphisms were associated with [11C]MADAM binding potential (BP) in most brain regions, male carriers of the valine/valine genotype of the Val66Met polymorphism displaying higher availability. Effect sizes ranged from a 50% to a threefold increase. In contrast, there was no association for [11C]WAY-100635 BP. The observation that BDNF polymorphisms were associated with 5-HTT availability could be partly replicated in an independent population comprising nine male suicide attempters and nine matched control subjects, in which transporter availability had been measured with single photon emission computed tomography with 123I-β-CIT as ligand. Conclusions: Our results suggest that genetic variation in BDNF influences 5-HTT but not 5-HT1A receptor density in the human brain. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
- View/download PDF
34. Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans.
- Author
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Borg, Jacqueline, Henningsson, Susanne, Saijo, Tomoyuki, Inoue, Makoto, Bah, Jessica, Westberg, Lars, Lundberg, Johan, Jovanovic, Hristina, Andreé, Bengt, Nordstrom, Anna-Lena, Halldin, Christer, Eriksson, Elias, and Farde, Lars
- Subjects
SEROTONIN ,GENETIC polymorphisms ,POSITRON emission tomography ,PATHOLOGICAL psychology ,COGNITIVE ability ,COGNITIVE testing - Abstract
The human serotonin transporter (5-HTT) gene is one of the most extensively studied in psychiatry. A functional polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR) has been associated with several psychiatric disorders as well as anxiety-related personality traits. In search of a mechanistic understanding of the functional implications of 5-HTTLPR, the influence of this polymorphism on regional 5-HT
1A receptor density has previously been examined in two positron emission tomography (PET) studies in humans, yielding, however, contradictory results. In the present study, 54 control subjects were examined with [11 C]WAY 100635 PET and a battery of cognitive tests. Regional binding potential (BP) of [11 C]WAY 100635 to 5-HT1A receptor was calculated for the dorsal raphe nuclei, the hippocampus, the anterior cingulate, the insula, the temporal cortex and the frontal cortex. The influence of 5-HTTLPR genotype on regional 5-HT1A BP and cognitive performance was investigated. No differences in 5-HT1A receptor density between carriers and non-carriers of the S allele were found. Thus, we could not replicate any of the previously reported associations between 5-HTTLPR and 5-HT1A density. There was, however, a highly significant association between 5-HTTLPR genotype and performance in Wisconsin Card Sorting Test ; carriers of the S allele had a superior performance compared to the LL carriers. These observations suggest that functional implications of the 5-HTTLPR polymorphism are not likely to be mediated by differences in 5-HT1A expression levels and that other biomarkers must be considered for future investigations at phenotype level. [ABSTRACT FROM AUTHOR]- Published
- 2009
- Full Text
- View/download PDF
35. A Link between Serotonin-Related Gene Polymorphisms, Amygdala Activity, and Placebo-Induced Relief from Social Anxiety.
- Author
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Furmark, Tomas, Appel, Lieuwe, Henningsson, Susanne, Åhs, Fredrik, Faria, Vanda, Linnman, Clas, Pissiota, Anna, Frans, Örjan, Bani, Massimo, Bettica, Paolo, Pich, Emilio Merlo, Jacobsson, Eva, Wahlstedt, Kurt, Oreland, Lars, Långström, Bengt, Eriksson, Elias, and Fredrikson, Mats
- Subjects
AMYGDALOID body ,PLACEBOS ,BRAIN imaging ,ANXIETY disorders ,SOCIAL anxiety ,SEROTONIN ,GENETIC polymorphisms - Abstract
Placebo may yield beneficial effects that are indistinguishable from those of active medication, but the factors underlying proneness to respond to placebo are widely unknown. Here, we used functional neuroimaging to examine neural correlates of anxiety reduction resulting from sustained placebo treatment under randomized double-blind conditions, in patients with social anxiety disorder. Brain activity was assessed during a stressful public speaking task by means of positron emission tomography before and after an 8 week treatment period. Patients were genotyped with respect to the serotonin transporter-linked polymorphic region (5-HTTLPR) and the G-703T polymorphism in the tryptophan hydroxylase-2 (TPH2) gene promoter. Results showed that placebo response was accompanied by reduced stress-related activity in the amygdala, a brain region crucial for emotional processing. However, attenuated amygdala activity was demonstrable only in subjects who were homozygous for the long allele of the 5-HTTLPR or the G variant of the TPH2 G-703T polymorphism, and not in carriers of short or T alleles. Moreover, the TPH2 polymorphism was a significant predictor of clinical placebo response, homozygosity for theGallele being associated with greater improvement in anxiety symptoms. Path analysis supported that the genetic effect on symptomatic improvement with placebo is mediated by its effect on amygdala activity. Hence, our study shows, for the first time, evidence of a link between genetically controlled serotonergic modulation of amygdala activity and placebo-induced anxiety relief. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
36. Interleukin-6 Gene Polymorphism −174G/C Influences Plasma Lipid Levels in Women*.
- Author
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Henningsson, Susanne, Håkansson, Anna, Westberg, Lars, Baghaei, Fariba, Rosmond, Roland, Holm, Göran, Ekman, Agneta, Nissbrandt, Hans, and Eriksson, Elias
- Published
- 2006
- Full Text
- View/download PDF
37. Interleukin-6 gene polymorphism -174G/C influences plasma lipid levels in women.
- Author
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Henningsson S, Håkansson A, Westberg L, Baghaei F, Rosmond R, Holm G, Ekman A, Nissbrandt H, and Eriksson E
- Subjects
- Adult, Body Mass Index, Female, Gene Frequency, Genotype, Humans, Interleukin-6 blood, Male, Middle Aged, Sex Factors, Triglycerides blood, Triglycerides metabolism, Interleukin-6 genetics, Lipid Metabolism genetics, Lipids blood, Polymorphism, Genetic
- Abstract
Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6) have been associated with cardiovascular risk factors. The objective of this study was to investigate potential associations between the promoter polymorphism IL-6 -174G/C and the following indices of metabolism: BMI, waist-to-hip ratio, and plasma levels of IL-6, cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, leptin, and C-reactive protein in 252 42-year-old women and 245 51-year-old men. Subgroups were also studied 5 years later. The CC genotype of the IL-6 polymorphism was associated with lower levels of cholesterol and low-density lipoprotein (p < 0.001) in women. This finding was replicated in the follow-up, when a significant association between the CC genotype and low triglycerides was also observed. The association between the C allele and lipid pattern found in women was not found in men, where on the contrary, C carriers tended to display elevated triglycerides. IL-6 genotype was not associated with IL-6 plasma levels in either sample. The results suggest different effects of the IL-6 polymorphism on metabolic indices in women and men. None of the associations between IL-6 genotype and lipid pattern seemed to result from an effect of the polymorphism on IL-6 plasma levels.
- Published
- 2006
- Full Text
- View/download PDF
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