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Abstract Background Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic disease that involves the infiltration of IgG4-positive plasma cells in multiple organs. Kimura disease (KD) presents as subcutaneous masses on the head and neck, frequently accompanied by eosinophilia and high immunoglobulin E (IgE) levels. Here, we report a rare case of concurrence of IgG4-RD and KD with manifestations of asthma, pulmonary embolism, and central diabetes insipidus accompanied by lung carcinoma. Case presentation A 65-year-old Chinese male with an eight-year history of KD was admitted to our hospital with complaints of dyspnea and expectoration for one month. Laboratory examination showed a considerable elevation in the serum eosinophil count and total IgE and IgG4 levels. Chest enhanced computed tomography showed filling defects in the right pulmonary artery and a nodule in the left inferior lobe. Pancreatic enhanced magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography showed a swollen pancreatic tail and local stricture of the pancreatic duct section of the common bile duct. Enhanced MRI of the pituitary gland showed thickening of the pituitary stalk. Additionally, immunohistochemistry of the specimens collected eight years prior revealed IgG4-positive cells. Following the diagnosis of IgG4-RD with KD, glucocorticoids with immunosuppressants were initiated; there was a prompt improvement in the patient’s condition. One-year post-discharge, the patient underwent wedge-shaped resection of the lung due to enlargement of the pulmonary nodule, and the pathology revealed lung squamous carcinoma. Conclusions This case presents a rare clinical condition in which the concurrence of IgG4-RD and KD causes various rare manifestations including asthma, pulmonary embolism, central diabetes insipidus, and complicated lung carcinoma. This highlights the importance of monitoring for malignancies in IgG4-RD patients during follow-up.

Abstract In light of the crucial role of marine ecosystems and the escalating environmental conservation challenges, it is essential to conduct marine monitoring to help implement targeted environmental protection measures efficiently. Energy harvesting technologies, particularly triboelectric nanogenerators (TENGs), have great potential for prolonging the lifespan and enhancing the reliability of sensors in remote areas. However, the high internal resistance, low current, and friction-induced abrasion issues of TENGs limit their performance in practical applications. This work presents a rolling mode triboelectric nanogenerator that utilizes multi-tunnel grating electrodes and the opposite-charge-enhancement mechanism to harvest wave energy efficiently. The device achieves significant instantaneous and root mean square power density of 185.4 W/(m3·Hz) and 10.92 W/(m3·Hz), respectively. By utilizing stacked devices and an exclusively designed power management module, a self-powered ocean sensing system including computing and long-range wireless communication (0.8 km) capabilities was developed. Laboratory and in-situ ocean tests were conducted to assess and validate the system. This work offers a potential solution for the challenging deployment of marine self-powered sensing nodes.

Summary: Previous studies have demonstrated that gut microbiota dysbiosis promotes the development of mastitis. The interaction of the vagus nerve and gut microbiota endows host homeostasis and regulates disease development, but whether the vagus nerve participates in the pathogenesis of mastitis is unclear. Here, vagotomized mice exhibit disruption of the blood-milk barrier and mammary gland inflammation. Notably, mastitis and barrier damage caused by vagotomy are dependent on the gut microbiota, as evidenced by antibiotic treatment and fecal microbiota transplantation. Vagotomy significantly alters the gut microbial composition and tryptophan metabolism and reduces the 5-hydroxyindole acetic acid (5-HIAA) level. Supplementation with 5-HIAA alleviates vagotomy-induced mastitis, which is associated with the activation of the aryl hydrocarbon receptor (AhR) and subsequent inhibition of the NF-κB pathway. Collectively, our findings indicate the important role of the vagus-mediated gut-mammary axis in the pathogenesis of mastitis and imply a potential strategy for the treatment of mastitis by targeting the vagus-gut microbiota interaction.

Mastitis is an inflammatory response of the mammary tissue caused by pathogenic bacterial infections, especially Staphylococcus aureus (S. aureus). Zearalenone (ZEA) is one of the common mycotoxins in moldy feed, which usually affects the cow's resistance to pathogenic microorganisms. However, it is not well understood whether ZEA affects the development of mastitis. Therefore, this study aimed to investigate the role of ZEA in the development of S. aureus-induced mastitis in mice. The results showed that administered daily by gavage for one week of ZEA (40 mg/kg) aggravated the severity of mastitis induced by S. aureus. Furthermore, we found that ZEA promotes the adhesion and invasion of S. aureus into mouse mammary epithelial cells (MMEC) by activating autophagy, and the activation of autophagy mediated by ROS-AMPK-m-TOR pathway. Taken together, the results showed that ZEA enhances S. aureus-induced mastitis susceptibility through activating autophagy mediated by ROS-AMPK-mTOR signaling pathway.

The rational assessment of regional energy distribution provides a scientific basis for the selection and siting of power generation units. This study, which focused on the Bohai Sea, set 31 research coordinate points in the Bohai sea for assessing the potential/trends of wave energy flux (WEF). We applied a point-to-point time series prediction method which modelled the different geographical coordinate points separately. Subsequently, we evaluated the performance of three traditional machine learning methods and three automated machine learning methods. To estimate WEF, the best model was applied to each research coordinate points, respectively. Then, the WEF was calculated and predicted based on the data of MWP, SWH, and water depth. The results indicate that, for all coordinates in the Bohai Sea, the H2O-AutoML algorithm is superior to the other five algorithms. Gradient boosting machine (GBM), extreme gradient boosting (XGBoost), and stacked ensemble models yielded the best performance out of the H2O algorithms. The significant wave height (SWH), the mean wave period (MWP), and the WEF in the Bohai Sea tended to be concentrated in the center of the sea and dispersed in the nearshore areas. In the year 2000, 2010, 2020, and 2030, the maximum annual average WEF at each research coordinate in the Bohai Sea is around 1.5 kW/m, with a higher flux in autumn and winter. In summary, the results provide ocean parameter characterization for the design and deployment of wave energy harvesting devices. Moreover, the automated machine learning introduced herein has potential for use in more applications in ocean engineering.

Objectives: To describe the clinical characteristics of septic pulmonary embolism in adults in order to improve its diagnosis and treatment. Methods: Specific search terms were used for retrieval from commonly used Chinese and English databases and the articles were selected in accordance with the inclusion and exclusion criteria. Cases from the included articles were pooled; then the following parameters were analyzed: major risk factors, clinical manifestations, imaging findings, characteristics of pathogenic microorganisms, complications and other clinical characteristics. Results: After strictly selected by the inclusion and exclusion criteria, 76 articles were selected (2 Chinese articles and 74 English articles) that described 168 cases. The major risk factors for SPE were intravenous drug use (n = 44), intravascular indwelling catheter (n = 21) and skin or soft tissue purulent infection (n = 10). The most frequent clinical manifestations were fever (n = 144), dyspnea (n = 81), chest pain (n = 82) and cough (n = 69). Chest CT showed multiple peripheral nodules in both lungs (n = 89), cavitation (n = 75), focal or wedge-shaped infiltrates (n = 48) and pleural effusion (n = 40). Echocardiography often revealed vegetations (n = 52). Blood cultures grew methicillin-resistant Staphylococcus aureus (MRSA) (n = 27), methicillin-sensitive Staphylococcus aureus (MSSA) (n = 48) and Candida (n = 6). Seventeen cases died and 101 cases were cured. Conclusions: SPE is a rare disease without specific clinical manifestations. For high-risk groups, such as intravenous drug users or patients with intravascular indwelling catheters, fever and imaging findings of multiple nodules or local infiltrates, with or without cavitation, are highly suggestive of SPE. Early diagnosis and prompt antimicrobial therapy or surgical intervention can lead to a successful treatment outcome. [ABSTRACT FROM AUTHOR]