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3 results on '"Hendrik Odendaal"'

1. Effects of Prenatal Exposure to Alcohol and Smoking on Fetal Heart Rate and Movement Regulation

Author

Maristella Lucchini, Lauren C. Shuffrey, J. David Nugent, Nicoló Pini, Ayesha Sania, Margaret Shair, Lucy Brink, Carlie du Plessis, Hein J. Odendaal, Morgan E. Nelson, Christa Friedrich, Jyoti Angal, Amy J. Elliott, Coen A. Groenewald, Larry T. Burd, Michael M. Myers, William P. Fifer, Gary DV Hankins, Kimberly A Dukes, Lisa M Sullivan, Tara Tripp, Fay Robinson, Cheri Raffo, Julie M Petersen, Rebecca A Young, Cindy Mai, Elena Grillo, Travis Baker, Gregory Toland, Michael Carmen, Hannah C Kinney, Robin L Haynes, Rebecca D Folkerth, Ingrid A Holm, Theonia Boyd, David S Paterson, Hanno Steen, Kyriacos Markianos, Drucilla Roberts, Kevin G Broadbelt, Richard G Goldstein, Laura L. Nelsen, Jacob Cotton, Perri Jacobs, Amy J Elliott, Larr Burd, Jessica Gromer, H Eugene Hoyme, Margaret Jackson, Luke Mack, Bradley B Randall, Mary Ann Sens, Deborah Tobacco, Peter Van Eerden, Hendrik Odendaal, Colleen Wright, Lut Geerts, Greetje de Jong, Pawel Schubert, Shabbir Wadee, Johan Dempers, Elsie Burger, Janetta Harbron, Coen Groenewald, William Fifer, Michael Myers, Joseph Isler, Yvonne Sininger, J David Nugent, Carmen Condon, Margaret C Shair, Tracy Thai, Marian Willinger, Dale Hereld, Howard J Hoffman, and Chuan-Ming Li

Subjects
fetal heart rate, fetal movement, autonomic nervous system, prenatal, alcohol, smoking, Physiology, QP1-981
Abstract

Negative associations of prenatal tobacco and alcohol exposure (PTE and PAE) on birth outcomes and childhood development have been well documented, but less is known about underlying mechanisms. A possible pathway for the adverse fetal outcomes associated with PTE and PAE is the alteration of fetal autonomic nervous system development. This study assessed PTE and PAE effects on measures of fetal autonomic regulation, as quantified by heart rate (HR), heart rate variability (SD-HR), movement, and HR-movement coupling in a population of fetuses at ≥ 34 weeks gestational age. Participants are a subset of the Safe Passage Study, a prospective cohort study that enrolled pregnant women from clinical sites in Cape Town, South Africa, and the Northern Plains region, United States. PAE was defined by six levels: no alcohol, low quit early, high quit early, low continuous, moderate continuous, and high continuous; while PTE by 4 levels: no smoking, quit early, low continuous, and moderate/high continuous. Linear regression analyses of autonomic measures were employed controlling for fetal sex, gestational age at assessment, site, maternal education, household crowding, and depression. Analyses were also stratified by sleep state (1F and 2F) and site (South Africa, N = 4025, Northern Plains, N = 2466). The final sample included 6491 maternal-fetal-dyad assessed in the third trimester [35.21 ± 1.26 (mean ± SD) weeks gestation]. PTE was associated with a decrease in mean HR in state 2F, in a dose dependent fashion, only for fetuses of mothers who continued smoking after the first trimester. In state 1F, there was a significant increase in mean HR in fetuses whose mother quit during the first trimester. This effect was driven by the Norther Plains cohort. PTE was also associated with a significant reduction in fetal movement in the most highly exposed group. In South Africa a significant increase in mean HR both for the high quit early and the high continuous group was observed. In conclusion, this investigation addresses a critical knowledge gap regarding the relationship between PTE and PAE and fetal autonomic regulation. We believe these results can contribute to elucidating mechanisms underlying risk for adverse outcomes.

Published
2021
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3. Drinking and smoking patterns during pregnancy: Development of group-based trajectories in the Safe Passage Study

Author

Kimberly Dukes, Tara Tripp, Marian Willinger, Hein Odendaal, Amy J. Elliott, Hannah C. Kinney, Fay Robinson, Julie M. Petersen, Cheryl Raffo, Dale Hereld, Coen Groenewald, Jyoti Angal, Gary Hankins, Larry Burd, William P. Fifer, Michael M. Myers, Howard J. Hoffman, Lisa Sullivan, Gary D.V. Hankins, Kimberly A. Dukes, Lisa M. Sullivan, Cheri Raffo, Rebecca A. Young, Cindy Mai, Elena Grillo, Travis Baker, Patti Folan, Gregory Toland, Michael Carmen, Robin L. Haynes, Rebecca D. Folkerth, Ingrid A. Holm, Theonia Boyd, David S. Paterson, Hanno Steen, Kyriacos Markianos, Drucilla Roberts, Kevin G. Broadbelt, Richard G. Goldstein, Laura L. Nelsen, Jacob Cotton, Perri Jacobs, Elizabeth Berg, Jessica Gromer, H Eugene Hoyme, Margaret Jackson, Luke Mack, Bethany Norton, Bradley B. Randall, Mary Ann Sens, Liz Swenson, Deborah Tobacco, Peter Van Eerden, Hendrik Odendaal, Colleen Wright, Lut Geerts, Greetje de Jong, Pawel Schubert, Shabbir Wadee, Johan Dempers, Elsie Burger, Janetta Harbron, Erna Carstens, William Fifer, Michael Myers, Joseph Isler, Yvonne Sininger, J David Nugent, Carmen Condon, Margaret C. Shair, Tracy Thai, and Chuan-Ming Li

Subjects
Adult, Group based, Health (social science), Alcohol Drinking, medicine.medical_treatment, Gestational Age, Toxicology, Third trimester, Biochemistry, White People, Article, Developmental psychology, South Africa, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, Fetus, 0302 clinical medicine, Pregnancy, Risk Factors, Tobacco Smoking, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Depression (differential diagnoses), Ethanol, business.industry, Smoking, Pregnancy Outcome, General Medicine, medicine.disease, United States, Mixed ancestry, Neurology, Cohort, Indians, North American, Smoking cessation, Female, Alcohol intake, Self Report, business, 030217 neurology & neurosurgery, Demography
Abstract

Precise identification of drinking and smoking patterns during pregnancy is crucial to better understand the risk to the fetus. The purpose of this manuscript is to describe the methodological approach used to define prenatal drinking and smoking trajectories from a large prospective pregnancy cohort, and to describe maternal characteristics associated with different exposure patterns. In the Safe Passage Study, detailed information regarding quantity, frequency, and timing of exposure was self-reported up to four times during pregnancy and at 1 month post-delivery. Exposure trajectories were developed using data from 11,692 pregnancies (9,912 women) where pregnancy outcome was known. Women were from three diverse populations: white (23%) and American Indian (17%) in the Northern Plains, US, and mixed ancestry (59%) in South Africa (other/not specified [1%]). Group-based trajectory modeling was used to identify 5 unique drinking trajectories (1 none/minimal, 2 quitting groups, 2 continuous groups) and 7 smoking trajectories (1 none/minimal, 2 quitting groups, 4 continuous groups). Women with pregnancies assigned to the low- or high-continuous drinking groups were less likely to have completed high school and were more likely to have enrolled in the study in the third trimester, be of mixed ancestry, or be depressed than those assigned to the none/minimal or quit-drinking groups. Results were similar when comparing continuous smokers to none/minimal and quit-smoking groups. Further, women classified as high- or low-continuous drinkers were more likely to smoke at moderate-, high-, and very high-continuous levels, as compared to women classified as non-drinkers and quitters. This is the first study of this size to utilize group-based trajectory modeling to identify unique prenatal drinking and smoking trajectories. These trajectories will be used in future analyses to determine which specific exposure patterns subsequently manifest as poor peri- and postnatal outcomes.

Published
2017

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