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Your search keyword '"Hendrickson, Sher L."' showing total 26 results
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26 results on '"Hendrickson, Sher L."'

1. Response to Bakker et al.

Author

Robinson, Jacqueline A, Bowie, Rauri CK, Dudchenko, Olga, Aiden, Erez Lieberman, Hendrickson, Sher L, Steiner, Cynthia C, Ryder, Oliver A, Mindell, David P, and Wall, Jeffrey D

Subjects
Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology
Abstract

Robinson and colleagues respond to the points raised about their paper by Bakker et al.

Published
2022

2. Genome-wide diversity in the California condor tracks its prehistoric abundance and decline

Author

Robinson, Jacqueline A, Bowie, Rauri CK, Dudchenko, Olga, Aiden, Erez Lieberman, Hendrickson, Sher L, Steiner, Cynthia C, Ryder, Oliver A, Mindell, David P, and Wall, Jeffrey D

Subjects
Human Genome, Genetics, Life on Land, Animals, Ecosystem, Endangered Species, Falconiformes, Female, Genome, Genomics, Population Density, conservation, demographic history, extinction, genomics, inbreeding, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology
Abstract

Due to their small population sizes, threatened and endangered species frequently suffer from a lack of genetic diversity, potentially leading to inbreeding depression and reduced adaptability.1 During the latter half of the twentieth century, North America's largest soaring bird,2 the California condor (Gymnogyps californianus; Critically Endangered3), briefly went extinct in the wild. Though condors once ranged throughout North America, by 1982 only 22 individuals remained. Following decades of captive breeding and release efforts, there are now >300 free-flying wild condors and ∼200 in captivity. The condor's recent near-extinction from lead poisoning, poaching, and loss of habitat is well documented,4 but much about its history remains obscure. To fill this gap and aid future management of the species, we produced a high-quality chromosome-length genome assembly for the California condor and analyzed its genome-wide diversity. For comparison, we also examined the genomes of two close relatives: the Andean condor (Vultur gryphus; Vulnerable3) and the turkey vulture (Cathartes aura; Least Concern3). The genomes of all three species show evidence of historic population declines. Interestingly, the California condor genome retains a high degree of variation, which our analyses reveal is a legacy of its historically high abundance. Correlations between genome-wide diversity and recombination rate further suggest a history of purifying selection against linked deleterious alleles, boding well for future restoration. We show how both long-term evolutionary forces and recent inbreeding have shaped the genome of the California condor, and provide crucial genomic resources to enable future research and conservation.

Published
2021

5. Genome-Wide Association Study Implicates PARD3B-Based AIDS Restriction

Author

Troyer, Jennifer L., Nelson, George W., Lautenberger, James A., Chinn, Leslie, McIntosh, Carl, Johnson, Randall C., Sezgin, Efe, Kessing, Bailey, Malasky, Michael, Hendrickson, Sher L., Li, Guan, Pontius, Joan, Tang, Minzhong, An, Ping, Winkler, Cheryl A., Limou, Sophie, Le Clerc, Sigrid, Delaneau, Olivier, Zagury, Jean-François, Schuitemaker, Hanneke, van Manen, Daniëlle, Bream, Jay H., Gomperts, Edward D., Buchbinder, Susan, Goedert, James J., Kirk, Gregory D., and O'Brien, Stephen J.

Published
2011
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10. Effect of host genetics on CMV retinitis occurrence in patients with AIDS

Author

Sezgin, Efe, Jabs, Douglas A., Hendrickson, Sher L., Van Natta, Mark, Zdanov, Alexander, Lewis, Richard Alan, Smith, Michael W., Troyer, Jennifer L., and O’ Brien, Stephen J.

Subjects
Adult, Male, Acquired Immunodeficiency Syndrome, Polymorphism, Genetic, AIDS-Related Opportunistic Infections, Interleukin-10 Receptor alpha Subunit, Middle Aged, Article, Immunity, Innate, United States, White People, Interleukin-10, Black or African American, Gene Frequency, Cytomegalovirus Retinitis, Humans, Female, Genetic Predisposition to Disease, Longitudinal Studies
Abstract

Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.

Published
2010

13. The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove

Author

Tang, Minzhong, primary, Lautenberger, James A., additional, Gao, Xiaojiang, additional, Sezgin, Efe, additional, Hendrickson, Sher L., additional, Troyer, Jennifer L., additional, David, Victor A., additional, Guan, Li, additional, Mcintosh, Carl E., additional, Guo, Xiuchan, additional, Zheng, Yuming, additional, Liao, Jian, additional, Deng, Hong, additional, Malasky, Michael, additional, Kessing, Bailey, additional, Winkler, Cheryl A., additional, Carrington, Mary, additional, dé The, Guy, additional, Zeng, Yi, additional, and O'Brien, Stephen J., additional

Published
2012
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14. Risk Factors for Symptomatic Hyperlactatemia and Lactic Acidosis Among Combination Antiretroviral Therapy-Treated Adults in Botswana: Results from a Clinical Trial

Author

Wester, C. William, primary, Eden, Svetlana K., additional, Shepherd, Bryan E., additional, Bussmann, Hermann, additional, Novitsky, Vladimir, additional, Samuels, David C., additional, Hendrickson, Sher L., additional, Winkler, Cheryl A., additional, O'Brien, Stephen J., additional, Essex, Max, additional, D'Aquila, Richard T., additional, deGruttola, Victor, additional, and Marlink, Richard G., additional

Published
2012
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15. F5 The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve HLA Class I Antigen Recognition Groove

Author

Minzhong, Tang, primary, Lautenberger, James A., additional, Gao, Xiaojiang, additional, Sezgin, Efe, additional, Hendrickson, Sher L., additional, Troyer, Jennifer L., additional, David, Victor A., additional, Guan, Li, additional, Mcintosh, Carl E., additional, Raymond, Marilyn, additional, Guo, Xiuchan, additional, Zheng, Yuming, additional, Liao, Jian, additional, Deng, Hong, additional, Malasky, Michael, additional, Pontius, Joan, additional, Kessing, Bailey, additional, Carrington, Mary, additional, dé The, Guy, additional, Zeng, Yi, additional, and O'Brien, Stephen J., additional

Published
2012
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16. Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Author

Hendrickson, Sher L., primary, Lautenberger, James A., additional, Chinn, Leslie Wei, additional, Malasky, Michael, additional, Sezgin, Efe, additional, Kingsley, Lawrence A., additional, Goedert, James J., additional, Kirk, Gregory D., additional, Gomperts, Edward D., additional, Buchbinder, Susan P., additional, Troyer, Jennifer L., additional, and O'Brien, Stephen J., additional

Published
2010
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21. NPHS2 Variation in Sporadic Focal Segmental Glomerulosclerosis

Author

McKenzie, Louise M., primary, Hendrickson, Sher L., additional, Briggs, William A., additional, Dart, Richard A., additional, Korbet, Stephen M., additional, Mokrzycki, Michelle H., additional, Kimmel, Paul L., additional, Ahuja, Tejinder S., additional, Berns, Jeffrey S., additional, Simon, Eric E., additional, Smith, Michael C., additional, Trachtman, Howard, additional, Michel, Donna M., additional, Schelling, Jeffrey R., additional, Cho, Monique, additional, Zhou, Yu C., additional, Binns-Roemer, Elizabeth, additional, Kirk, Gregory D., additional, Kopp, Jeffrey B., additional, and Winkler, Cheryl A., additional

Published
2007
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25. The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove.

Author

Minzhong Tang, Lautenberger, James A., Xiaojiang Gao, Sezgin, Efe, Hendrickson, Sher L., Troyer, Jennifer L., David, Victor A., Li Guan, Mcintosh, Carl E., Xiuchan Guo, Yuming Zheng, Jian Liao, Hong Deng, Malasky, Michael, Kessing, Bailey, Winkler, Cheryl A., Carrington, Mary, dé The, Guy, Yi Zeng, and O'Brien, Stephen J.

Subjects
NASOPHARYNX cancer, MAJOR histocompatibility complex, HLA histocompatibility antigens, EPSTEIN-Barr virus diseases
Abstract

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy facilitated by Epstein-Barr Virus infection. Here we resolve the major genetic influences for NPC incidence using a genome-wide association study (GWAS), independent cohort replication, and high-resolution molecular HLA class I gene typing including 4,055 study participants from the Guangxi Zhuang Autonomous Region and Guangdong province of southern China. We detect and replicate strong association signals involving SNPs, HLA alleles, and amino acid (aa) variants across the major histocompatibility complex-HLA-A, HLA -B, and HLA -C class I genes (PHLA-A-aa-site-62 = 7.4 x10-29; PHLA-B-aa-site-116 = 6.56x10 ;PHLA-C-aa-site-156 = 6.8x10-8 respectively). Over 250 NPC-HLA associated variants within HLA were analyzed in concert to resolve separate and largely independent HLA-A, -B, and -C gene influences. Multivariate logistical regression analysis collapsed significant associations in adjacent genes spanning 500 kb (OR2H1, GABBR1, HLA-F, and HCG9) as proxies for peptide binding motifs carried by HLA- A*11:01. A similar analysis resolved an independent association signal driven by HLA-B*13:01, B*38:02, and B*55:02 alleles together. NPC resistance alleles carrying the strongly associated amino acid variants implicate specific class I peptide recognition motifs in HLA-A and -B peptide binding groove as conferring strong genetic influence on the development of NPC in China. [ABSTRACT FROM AUTHOR]

Published
2012
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26. Mitochondrial DNA haplogroups influence AIDS progression.

Author

Robson, David, Hendrickson, Sher L, Hutcheson, Holli B, Ruiz-Pesini, Eduardo, Poole, Jason C, Lautenberger, James, Sezgin, Efe, Kingsley, Lawrence, Goedert, James J, Vlahov, David, Donfield, Sharyne, Wallace, Douglas C, and O'Brien, Stephen J

Subjects
*HIV, *AIDS research, *DNA, *MITOCHONDRIA, *GENES
Abstract

Objective: Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA single-nucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis.Design: This is a retrospective cohort study.Methods: We performed an association study of mitochondrial DNA haplogroups among 1833 European American HIV-1 patients from five US cohorts: the Multicenter AIDS Cohort Study, the San Francisco City Clinic Study, Hemophilia Growth and Development Study, the Multicenter Hemophilia Cohort Study, and the AIDS Linked to Intravenous Experiences cohort to determine whether the mitochondrial DNA haplogroup correlated with AIDS progression rate.Results: Mitochondrial DNA haplogroups J and U5a were elevated among HIV-1 infected people who display accelerated progression to AIDS and death. Haplogroups Uk, H3, and IWX appeared to be highly protective against AIDS progression.Conclusion: The associations found in our study appear to support a functional explanation by which mitochondrial DNA variation among haplogroups, influencing ATP production, reactive oxygen species generation, and apoptosis, is correlated to AIDS disease progression; however, repeating these results in cohorts with different ethnic backgrounds would be informative. These data suggest that mitochondrial genes are important indicators of AIDS disease progression in HIV-1 infected persons. [ABSTRACT FROM AUTHOR]

Published
2008
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