36 results on '"Henderson, M.J."'
Search Results
2. Adult-Gerontology Nurse Practitioners: A Discussion of Scope and Expertise
- Author
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Peacock, Amanda, Blakely, Kala, Maes, Cheryl, Henson, Autumn, DiGiulio, Mary, and Henderson, M.J.
- Published
- 2022
- Full Text
- View/download PDF
3. Prognostic gene expression signature for high-grade serous ovarian cancer
- Author
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Bowtell, D., Chenevix-Trench, G., Green, A., Webb, P., DeFazio, A., Gertig, D., Traficante, N., Fereday, S., Moore, S., Hung, J., Harrap, K., Sadkowsky, T., Pandeya, N., Malt, M., Mellon, A., Robertson, R., Vanden Bergh, T., Jones, M., Mackenzie, P., Maidens, J., Nattress, K., Chiew, Y.E., Stenlake, A., Sullivan, H., Alexander, B., Ashover, P., Brown, S., Corrish, T., Green, L., Jackman, L., Ferguson, K., Martin, K., Martyn, A., Ranieri, B., White, J., Jayde, V., Mamers, P., Bowes, L., Galletta, L., Giles, D., Hendley, J., Alsop, K., Schmidt, T., Shirley, H., Ball, C., Young, C., Viduka, S., Tran, Hoa, Bilic, Sanela, Glavinas, Lydia, Brooks, Julia, Stuart-Harris, R., Kirsten, F., Rutovitz, J., Clingan, P., Glasgow, A., Proietto, A., Braye, S., Otton, G., Shannon, J., Bonaventura, T., Stewart, J., Begbie, S., Friedlander, M., Bell, D., Baron-Hay, S., Ferrier,a, A., Gard, G., Nevell, D., Pavlakis, N., Valmadre, S., Young, B., Camaris, C., Crouch, R., Edwards, L., Hacker, N., Marsden, D., Robertson, G., Beale, P., Beith, J., Carter, J., Dalrymple, C., Houghton, R., Russell, P., Links, M., Grygiel, J., Hill, J., Brand, A., Byth, K., Jaworski, R., Harnett, P., Sharma, R., Wain, G., Ward, B., Papadimos, D., Crandon, A., Cummings, M., Horwood, K., Obermair, A., Perrin, L., Wyld, D., Nicklin, J., Davy, M., Oehler, M.K., Hall, C., Dodd, T., Healy, T., Pittman, K., Henderson, D., Miller, J., Pierdes, J., Blomfield, P., Challis, D., McIntosh, R., Parker, A., Brown, B., Rome, R., Allen, D., Grant, P., Hyde, S., Laurie, R., Robbie, M., Healy, D., Jobling, T., Manolitsas, T., McNealage, J., Rogers, P., Susil, B., Sumithran, E., Simpson, I., Phillips, K., Rischin, D., Fox, S., Johnson, D., Lade, S., Loughrey, M., O’Callaghan, N., Murray, W., Waring, P., Billson, V., Pyman, J., Neesham, D., Quinn, M., Underhill, C., Bell, R., Ng, L.F., Blum, R., Ganju, V., Hammond, I., Leung, Y., McCartney, A., Buck, M., Haviv, I., Purdie, D., Whiteman, D., Zeps, N., Millstein, J., Budden, T., Goode, E.L., Anglesio, M.S., Talhouk, A., Intermaggio, M.P., Leong, H.S., Chen, S., Elatre, W., Gilks, B., Nazeran, T., Volchek, M., Bentley, R.C., Wang, C., Chiu, D.S., Kommoss, S., Leung, S.C.Y., Senz, J., Lum, A., Chow, V., Sudderuddin, H., Mackenzie, R., George, J., Steed, H., Koziak, J.M., Köbel, M., McNeish, I.A., Goranova, T., Ennis, D., Macintyre, G., Silva De Silva, D., Ramón y Cajal, T., García-Donas, J., Hernando Polo, S., Rodriguez, G.C., Cushing-Haugen, K.L., Harris, H.R., Greene, C.S., Zelaya, R.A., Behrens, S., Fortner, R.T., Sinn, P., Herpel, E., Lester, J., Lubiński, J., Oszurek, O., Tołoczko, A., Cybulski, C., Menkiszak, J., Pearce, C.L., Pike, M.C., Tseng, C., Alsop, J., Rhenius, V., Song, H., Jimenez-Linan, M., Piskorz, A.M., Gentry-Maharaj, A., Karpinskyj, C., Widschwendter, M., Singh, N., Kennedy, C.J., Harnett, P.R., Gao, B., Johnatty, S.E., Sayer, R., Boros, J., Winham, S.J., Keeney, G.L., Kaufmann, S.H., Larson, M.C., Luk, H., Hernandez, B.Y., Thompson, P.J., Wilkens, L.R., Carney, M.E., Trabert, B., Lissowska, J., Brinton, L., Sherman, M.E., Bodelon, C., Hinsley, S., Lewsley, L.A., Glasspool, R., Banerjee, S.N., Stronach, E.A., Haluska, P., Ray-Coquard, I., Mahner, S., Winterhoff, B., Slamon, D., Levine, D.A., Kelemen, L.E., Benitez, J., Chang-Claude, J., Gronwald, J., Wu, A.H., Menon, U., Goodman, M.T., Schildkraut, J.M., Wentzensen, N., Brown, R., Berchuck, A., deFazio, A., Gayther, S.A., García, M.J., Henderson, M.J., Rossing, M.A., Beeghly-Fadiel, A., Fasching, P.A., Orsulic, S., Karlan, B.Y., Konecny, G.E., Huntsman, D.G., Bowtell, D.D., Brenton, J.D., Doherty, J.A., Pharoah, P.D.P., and Ramus, S.J.
- Published
- 2020
- Full Text
- View/download PDF
4. Estimation of summer flounder (Paralichthys dentatus) mortality rates using mark-recapture data from a recreational angler-tagging program
- Author
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Henderson, M.J. and Fabrizio, M.C.
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- 2014
- Full Text
- View/download PDF
5. Movement patterns of summer flounder near an artificial reef: Effects of fish size and environmental cues
- Author
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Henderson, M.J., Fabrizio, M.C., and Lucy, J.A.
- Published
- 2014
- Full Text
- View/download PDF
6. An X-ray diffraction study of oriented lithium-N,N,N′,N′-tetramethyl-ethane-1,2-diamine intercalated graphite
- Author
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Henderson, M.J., Nishimura, T., and White, J.W.
- Published
- 2013
- Full Text
- View/download PDF
7. Visible light induced cell damage of Gram positive bacteria by N-doped TiO2 mesoporous thin films
- Author
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Soni, S.S., Dave, G.S., Henderson, M.J., and Gibaud, A.
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- 2013
- Full Text
- View/download PDF
8. 778 Designing and utilizing a c-Rel specific bioassay in drug repurposing screen for HNSCC
- Author
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Altwegg, K.A., King, K., Blivis, D., Voss, T., Martinez, N.J., Henderson, M.J., and Weinberg, W.C.
- Published
- 2024
- Full Text
- View/download PDF
9. Measurable residual disease detection in acute lymphoblastic leukaemia – comparison between NGS and ASO-qPCR
- Author
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Lane, J., Ong, E., Schreiber, B., Habiba, U., Leyton, A., Giles, J., Trahair, T., Sutton, R., Lee, L., Stevenson, W., and Henderson, M.J.
- Published
- 2024
- Full Text
- View/download PDF
10. Swelling of a mesostructured zirconium oxide film
- Author
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Henderson, M.J., Rennie, A.R., Hawley, A.M., and White, J.W.
- Published
- 2006
- Full Text
- View/download PDF
11. Prognostic gene expression signature for high-grade serous ovarian cancer
- Author
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Millstein, J., primary, Budden, T., additional, Goode, E.L., additional, Anglesio, M.S., additional, Talhouk, A., additional, Intermaggio, M.P., additional, Leong, H.S., additional, Chen, S., additional, Elatre, W., additional, Gilks, B., additional, Nazeran, T., additional, Volchek, M., additional, Bentley, R.C., additional, Wang, C., additional, Chiu, D.S., additional, Kommoss, S., additional, Leung, S.C.Y., additional, Senz, J., additional, Lum, A., additional, Chow, V., additional, Sudderuddin, H., additional, Mackenzie, R., additional, George, J., additional, Fereday, S., additional, Hendley, J., additional, Traficante, N., additional, Steed, H., additional, Koziak, J.M., additional, Köbel, M., additional, McNeish, I.A., additional, Goranova, T., additional, Ennis, D., additional, Macintyre, G., additional, Silva De Silva, D., additional, Ramón y Cajal, T., additional, García-Donas, J., additional, Hernando Polo, S., additional, Rodriguez, G.C., additional, Cushing-Haugen, K.L., additional, Harris, H.R., additional, Greene, C.S., additional, Zelaya, R.A., additional, Behrens, S., additional, Fortner, R.T., additional, Sinn, P., additional, Herpel, E., additional, Lester, J., additional, Lubiński, J., additional, Oszurek, O., additional, Tołoczko, A., additional, Cybulski, C., additional, Menkiszak, J., additional, Pearce, C.L., additional, Pike, M.C., additional, Tseng, C., additional, Alsop, J., additional, Rhenius, V., additional, Song, H., additional, Jimenez-Linan, M., additional, Piskorz, A.M., additional, Gentry-Maharaj, A., additional, Karpinskyj, C., additional, Widschwendter, M., additional, Singh, N., additional, Kennedy, C.J., additional, Sharma, R., additional, Harnett, P.R., additional, Gao, B., additional, Johnatty, S.E., additional, Sayer, R., additional, Boros, J., additional, Winham, S.J., additional, Keeney, G.L., additional, Kaufmann, S.H., additional, Larson, M.C., additional, Luk, H., additional, Hernandez, B.Y., additional, Thompson, P.J., additional, Wilkens, L.R., additional, Carney, M.E., additional, Trabert, B., additional, Lissowska, J., additional, Brinton, L., additional, Sherman, M.E., additional, Bodelon, C., additional, Hinsley, S., additional, Lewsley, L.A., additional, Glasspool, R., additional, Banerjee, S.N., additional, Stronach, E.A., additional, Haluska, P., additional, Ray-Coquard, I., additional, Mahner, S., additional, Winterhoff, B., additional, Slamon, D., additional, Levine, D.A., additional, Kelemen, L.E., additional, Benitez, J., additional, Chang-Claude, J., additional, Gronwald, J., additional, Wu, A.H., additional, Menon, U., additional, Goodman, M.T., additional, Schildkraut, J.M., additional, Wentzensen, N., additional, Brown, R., additional, Berchuck, A., additional, Chenevix-Trench, G., additional, deFazio, A., additional, Gayther, S.A., additional, García, M.J., additional, Henderson, M.J., additional, Rossing, M.A., additional, Beeghly-Fadiel, A., additional, Fasching, P.A., additional, Orsulic, S., additional, Karlan, B.Y., additional, Konecny, G.E., additional, Huntsman, D.G., additional, Bowtell, D.D., additional, Brenton, J.D., additional, Doherty, J.A., additional, Pharoah, P.D.P., additional, Ramus, S.J., additional, Bowtell, D., additional, Green, A., additional, Webb, P., additional, DeFazio, A., additional, Gertig, D., additional, Moore, S., additional, Hung, J., additional, Harrap, K., additional, Sadkowsky, T., additional, Pandeya, N., additional, Malt, M., additional, Mellon, A., additional, Robertson, R., additional, Vanden Bergh, T., additional, Jones, M., additional, Mackenzie, P., additional, Maidens, J., additional, Nattress, K., additional, Chiew, Y.E., additional, Stenlake, A., additional, Sullivan, H., additional, Alexander, B., additional, Ashover, P., additional, Brown, S., additional, Corrish, T., additional, Green, L., additional, Jackman, L., additional, Ferguson, K., additional, Martin, K., additional, Martyn, A., additional, Ranieri, B., additional, White, J., additional, Jayde, V., additional, Mamers, P., additional, Bowes, L., additional, Galletta, L., additional, Giles, D., additional, Alsop, K., additional, Schmidt, T., additional, Shirley, H., additional, Ball, C., additional, Young, C., additional, Viduka, S., additional, Tran, Hoa, additional, Bilic, Sanela, additional, Glavinas, Lydia, additional, Brooks, Julia, additional, Stuart-Harris, R., additional, Kirsten, F., additional, Rutovitz, J., additional, Clingan, P., additional, Glasgow, A., additional, Proietto, A., additional, Braye, S., additional, Otton, G., additional, Shannon, J., additional, Bonaventura, T., additional, Stewart, J., additional, Begbie, S., additional, Friedlander, M., additional, Bell, D., additional, Baron-Hay, S., additional, Ferrier,a, A., additional, Gard, G., additional, Nevell, D., additional, Pavlakis, N., additional, Valmadre, S., additional, Young, B., additional, Camaris, C., additional, Crouch, R., additional, Edwards, L., additional, Hacker, N., additional, Marsden, D., additional, Robertson, G., additional, Beale, P., additional, Beith, J., additional, Carter, J., additional, Dalrymple, C., additional, Houghton, R., additional, Russell, P., additional, Links, M., additional, Grygiel, J., additional, Hill, J., additional, Brand, A., additional, Byth, K., additional, Jaworski, R., additional, Harnett, P., additional, Wain, G., additional, Ward, B., additional, Papadimos, D., additional, Crandon, A., additional, Cummings, M., additional, Horwood, K., additional, Obermair, A., additional, Perrin, L., additional, Wyld, D., additional, Nicklin, J., additional, Davy, M., additional, Oehler, M.K., additional, Hall, C., additional, Dodd, T., additional, Healy, T., additional, Pittman, K., additional, Henderson, D., additional, Miller, J., additional, Pierdes, J., additional, Blomfield, P., additional, Challis, D., additional, McIntosh, R., additional, Parker, A., additional, Brown, B., additional, Rome, R., additional, Allen, D., additional, Grant, P., additional, Hyde, S., additional, Laurie, R., additional, Robbie, M., additional, Healy, D., additional, Jobling, T., additional, Manolitsas, T., additional, McNealage, J., additional, Rogers, P., additional, Susil, B., additional, Sumithran, E., additional, Simpson, I., additional, Phillips, K., additional, Rischin, D., additional, Fox, S., additional, Johnson, D., additional, Lade, S., additional, Loughrey, M., additional, O’Callaghan, N., additional, Murray, W., additional, Waring, P., additional, Billson, V., additional, Pyman, J., additional, Neesham, D., additional, Quinn, M., additional, Underhill, C., additional, Bell, R., additional, Ng, L.F., additional, Blum, R., additional, Ganju, V., additional, Hammond, I., additional, Leung, Y., additional, McCartney, A., additional, Buck, M., additional, Haviv, I., additional, Purdie, D., additional, Whiteman, D., additional, and Zeps, N., additional
- Published
- 2020
- Full Text
- View/download PDF
12. A zirconium oxide film self-assembled at the air–water interface
- Author
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Henderson, M.J., Gibaud, A., Bardeau, J.-F., Rennie, A.R., and White, J.W.
- Published
- 2005
- Full Text
- View/download PDF
13. Corrosion of an aircraft radar antenna waveguide
- Author
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Russo, S.G, Henderson, M.J, and Hinton, B.R.W
- Published
- 2002
- Full Text
- View/download PDF
14. PO-405 Repositioning existing drugs as novel therapeutics for high-risk paediatric leukaemia
- Author
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Karsa, M., primary, Failes, T., additional, Arndt, G.M., additional, Kees, U.R., additional, Haber, M., additional, Norris, M.D., additional, Sutton, R., additional, Lock, R.B., additional, Somers, K., additional, and Henderson, M.J., additional
- Published
- 2018
- Full Text
- View/download PDF
15. Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
- Author
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Morris, A.A., Kozich, V., Santra, S., Andria, G., Ben-Omran, T.I., Chakrapani, A.B., Crushell, E., Henderson, M.J., Hochuli, M., Huemer, M., Janssen, M.C.H., Maillot, F., Mayne, P.D., McNulty, J., Morrison, T.M., Ogier, H., O'Sullivan, S., Pavlikova, M., Almeida, I.T. de, Terry, A., Yap, S., Blom, H.J., Chapman, K.A., Morris, A.A., Kozich, V., Santra, S., Andria, G., Ben-Omran, T.I., Chakrapani, A.B., Crushell, E., Henderson, M.J., Hochuli, M., Huemer, M., Janssen, M.C.H., Maillot, F., Mayne, P.D., McNulty, J., Morrison, T.M., Ogier, H., O'Sullivan, S., Pavlikova, M., Almeida, I.T. de, Terry, A., Yap, S., Blom, H.J., and Chapman, K.A.
- Abstract
Contains fulltext : 169680.pdf (publisher's version ) (Open Access), Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine. Patients can present to many different specialists and diagnosis is often delayed. Severely affected patients usually present in childhood with ectopia lentis, learning difficulties and skeletal abnormalities. These patients generally require treatment with a low-methionine diet and/or betaine. In contrast, mildly affected patients are likely to present as adults with thromboembolism and to respond to treatment with pyridoxine. In this article, we present recommendations for the diagnosis and management of CBS deficiency, based on a systematic review of the literature. Unfortunately, the quality of the evidence is poor, as it often is for rare diseases. We strongly recommend measuring the plasma total homocysteine concentrations in any patient whose clinical features suggest the diagnosis. Our recommendations may help to standardise testing for pyridoxine responsiveness. Current evidence suggests that patients are unlikely to develop complications if the plasma total homocysteine concentration is maintained below 120 mumol/L. Nevertheless, we recommend keeping the concentration below 100 mumol/L because levels fluctuate and the complications associated with high levels are so serious.
- Published
- 2017
16. A combined electrochemical quartz-crystal microbalance probe beam deflection (EQCM-PBD) study of solvent and ion transfers at a poly[Ni(saltMe)]: modified elecrode during redox switching
- Author
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Vilas-Boas, Miguel, Henderson, M.J., Freire, C., Hillman, A.R., and Vieil, E.
- Abstract
Submitted by Miguel Vilas Boas (mvboas@ipb.pt) on 2011-05-30T12:38:47Z No. of bitstreams: 1 04_eqcmpbd.pdf: 2417232 bytes, checksum: 43364c9dd193232e27f0cb2aa7a41288 (MD5) Made available in DSpace on 2011-07-18T11:18:24Z (GMT). No. of bitstreams: 1 04_eqcmpbd.pdf: 2417232 bytes, checksum: 43364c9dd193232e27f0cb2aa7a41288 (MD5) Previous issue date: 2000
- Published
- 2000
17. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial.
- Author
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Giroux M.-F., Prakash K.G., Serracino-Inglott F., Subramanian G., Symth J.V., Walker M.G., Clarke M., Davis M., Dixit S.A., Dorman P., Dyker A., Ford G., Golkar A., Jackson R., Jayakrishnan V., Lambert D., Lees T., Louw S., Mendelow A.D., Rodgers H., Rose J., Stansby G., Wyatt M., Baker T., Baldwin N., Jones L., Mitchell D., Munro E., Thornton M., Baker D., Davis N., Hamilton G., Platts A., Tibballs J., Beard J., Cleveland T., Dodd D., Gaines P., Lonsdale R., Nair R., Nassef A., Nawaz S., Venables G., Belli A., Clifton A., Cloud G., Halliday A., Markus H., McFarland R., Morgan R., Pereira A., Thompson A., Chataway J., Cheshire N., Gibbs R., Hammady M., Jenkins M., Malik I., Wolfe J., Adiseshiah M., Bishop C., Brew S., Brookes J., Jager R., Kitchen N., Ashleigh R., Butterfield S., Gamble G.E., Nasim A., O'Neill P., Wong J., Edwards R.D., Lees K.R., MacKay A.J., Moss J., Rogers P., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Hauw Lo T., Dorman P.J., Macdonald S., Lyrer P.A., McCollum C., Nederkoorn P.J., Brown M.M., Algra A., Bamford J., Bland M., Hacke W., Mas J.L., McGuire A.J., Sidhu P., Bradbury A., Collins R., Molyneux A., Naylor R., Warlow C., Ferro M., Thomas D., Featherstone R.F., Tindall H., McCabe D., Wallis A., Coward L., Brooks M., Chambers B., Chan A., Chu P., Clark D., Dewey H., Donnan G., Fell G., Hoare M., Molan M., Roberts A., Roberts N., Beiles B., Bladin C., Clifford C., Grigg M., New G., Bell R., Bower S., Chong W., Holt M., Saunder A., Than P.G., Gett S., Leggett D., McGahan T., Quinn J., Ray M., Wong A., Woodruff P., Foreman R., Schultz D., Scroop R., Stanley B., Allard B., Atkinson N., Cambell W., Davies S., Field P., Milne P., Mitchell P., Tress B., Yan B., Beasley A., Dunbabin D., Stary D., Walker S., Cras P., d'Archambeau O., Hendriks J.M.H., Van Schil P., Bosiers M., Deloose K., van Buggenhout E., De Letter J., Devos V., Ghekiere J., Vanhooren G., Astarci P., Hammer F., Lacroix V., Verhelst R., DeJaegher L., Peeters A., Verbist J., Blair J.-F., Caron J.L., Daneault N., Guilbert F., Lanthier S., Lebrun L.-H., Oliva V., Raymond J., Roy D., Soulez G., Weill A., Hill M., Hu W., Hudion M., Morrish W., Sutherland G., Alback A., Harno H., Ijas P., Kaste M., Lepantalo M., Mustanoja S., Paananen T., Porras M., Putaala J., Railo M., Sairanen T., Soinne L., Vehmas A., Vikatmaa P., Goertler M., Halloul Z., Skalej M., Brennan P., Kelly C., Leahy A., Moroney J., Thornton J., Koelemay M.J.W., Reekers J.A.A., Roos Y.B.W.E.M., Hendriks J.M., Koudstaal P.J., Pattynama P.M.T., van der Lugt A., van Dijk L.C., van Sambeek M.R.H.M., van Urk H., Verhagen H.J.M., Bruijninckx C.M.A., de Bruijn S.F., Keunen R., Knippenberg B., Mosch A., Treurniet F., van Dijk L., van Overhagen H., Wever J., de Beer F.C., van den Berg J.S.P., van Hasselt B.A.A.M., Zeilstra D.J., Boiten J., de Mol van Otterloo J.C.A., de Vries A.C., Lycklama a Nijeholt G.J., van der Kallen B.F.W., Blankensteijn J.D., De Leeuw F.E., Schultze Kool L.J., van der Vliet J.A., de Kort G.A.P., Kapelle L.J., Lo T.H., Mali W.P.T.M., Moll F., Verhagen H., Barber P.A., Bourchier R., Hill A., Holden A., Stewart J., Bakke S.J., Krohg-Sorensen K., Skjelland M., Tennoe B., Bialek P., Biejat Z., Czepiel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Lelek M., Polanski J., Kirbis J., Milosevic Z., Zvan B., Blasco J., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Branera J., Canovas D., Estela J., Gimenez Gaibar A., Perendreu J., Bjorses K., Gottsater A., Ivancev K., Maetzsch T., Sonesson B., Berg B., Delle M., Formgren J., Gillgren P., Kall T.-B., Konrad P., Nyman N., Takolander R., Andersson T., Malmstedt J., Soderman M., Wahlgren C., Wahlgren N., Binaghi S., Hirt L., Michel P., Ruchat P., Engelter S.T., Fluri F., Guerke L., Jacob A.L., Kirsch E., Radue E.-W., Stierli P., Wasner M., Wetzel S., Bonvin C., Kalangos A., Lovblad K., Murith N., Ruefenacht D., Sztajzel R., Higgins N., Kirkpatrick P.J., Martin P., Adam D., Bell J., Bradbury A.W., Crowe P., Gannon M., Henderson M.J., Sandler D., Shinton R.A., Scriven J.M., Wilmink T., D'Souza S., Egun A., Guta R., Punekar S., Seriki D.M., Thomson G., Brennan J.A., Enevoldson T.P., Gilling-Smith G., Gould D.A., Harris P.L., McWilliams R.G., Nasser H.-C., White R., Giroux M.-F., Prakash K.G., Serracino-Inglott F., Subramanian G., Symth J.V., Walker M.G., Clarke M., Davis M., Dixit S.A., Dorman P., Dyker A., Ford G., Golkar A., Jackson R., Jayakrishnan V., Lambert D., Lees T., Louw S., Mendelow A.D., Rodgers H., Rose J., Stansby G., Wyatt M., Baker T., Baldwin N., Jones L., Mitchell D., Munro E., Thornton M., Baker D., Davis N., Hamilton G., Platts A., Tibballs J., Beard J., Cleveland T., Dodd D., Gaines P., Lonsdale R., Nair R., Nassef A., Nawaz S., Venables G., Belli A., Clifton A., Cloud G., Halliday A., Markus H., McFarland R., Morgan R., Pereira A., Thompson A., Chataway J., Cheshire N., Gibbs R., Hammady M., Jenkins M., Malik I., Wolfe J., Adiseshiah M., Bishop C., Brew S., Brookes J., Jager R., Kitchen N., Ashleigh R., Butterfield S., Gamble G.E., Nasim A., O'Neill P., Wong J., Edwards R.D., Lees K.R., MacKay A.J., Moss J., Rogers P., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Hauw Lo T., Dorman P.J., Macdonald S., Lyrer P.A., McCollum C., Nederkoorn P.J., Brown M.M., Algra A., Bamford J., Bland M., Hacke W., Mas J.L., McGuire A.J., Sidhu P., Bradbury A., Collins R., Molyneux A., Naylor R., Warlow C., Ferro M., Thomas D., Featherstone R.F., Tindall H., McCabe D., Wallis A., Coward L., Brooks M., Chambers B., Chan A., Chu P., Clark D., Dewey H., Donnan G., Fell G., Hoare M., Molan M., Roberts A., Roberts N., Beiles B., Bladin C., Clifford C., Grigg M., New G., Bell R., Bower S., Chong W., Holt M., Saunder A., Than P.G., Gett S., Leggett D., McGahan T., Quinn J., Ray M., Wong A., Woodruff P., Foreman R., Schultz D., Scroop R., Stanley B., Allard B., Atkinson N., Cambell W., Davies S., Field P., Milne P., Mitchell P., Tress B., Yan B., Beasley A., Dunbabin D., Stary D., Walker S., Cras P., d'Archambeau O., Hendriks J.M.H., Van Schil P., Bosiers M., Deloose K., van Buggenhout E., De Letter J., Devos V., Ghekiere J., Vanhooren G., Astarci P., Hammer F., Lacroix V., Verhelst R., DeJaegher L., Peeters A., Verbist J., Blair J.-F., Caron J.L., Daneault N., Guilbert F., Lanthier S., Lebrun L.-H., Oliva V., Raymond J., Roy D., Soulez G., Weill A., Hill M., Hu W., Hudion M., Morrish W., Sutherland G., Alback A., Harno H., Ijas P., Kaste M., Lepantalo M., Mustanoja S., Paananen T., Porras M., Putaala J., Railo M., Sairanen T., Soinne L., Vehmas A., Vikatmaa P., Goertler M., Halloul Z., Skalej M., Brennan P., Kelly C., Leahy A., Moroney J., Thornton J., Koelemay M.J.W., Reekers J.A.A., Roos Y.B.W.E.M., Hendriks J.M., Koudstaal P.J., Pattynama P.M.T., van der Lugt A., van Dijk L.C., van Sambeek M.R.H.M., van Urk H., Verhagen H.J.M., Bruijninckx C.M.A., de Bruijn S.F., Keunen R., Knippenberg B., Mosch A., Treurniet F., van Dijk L., van Overhagen H., Wever J., de Beer F.C., van den Berg J.S.P., van Hasselt B.A.A.M., Zeilstra D.J., Boiten J., de Mol van Otterloo J.C.A., de Vries A.C., Lycklama a Nijeholt G.J., van der Kallen B.F.W., Blankensteijn J.D., De Leeuw F.E., Schultze Kool L.J., van der Vliet J.A., de Kort G.A.P., Kapelle L.J., Lo T.H., Mali W.P.T.M., Moll F., Verhagen H., Barber P.A., Bourchier R., Hill A., Holden A., Stewart J., Bakke S.J., Krohg-Sorensen K., Skjelland M., Tennoe B., Bialek P., Biejat Z., Czepiel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Lelek M., Polanski J., Kirbis J., Milosevic Z., Zvan B., Blasco J., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Branera J., Canovas D., Estela J., Gimenez Gaibar A., Perendreu J., Bjorses K., Gottsater A., Ivancev K., Maetzsch T., Sonesson B., Berg B., Delle M., Formgren J., Gillgren P., Kall T.-B., Konrad P., Nyman N., Takolander R., Andersson T., Malmstedt J., Soderman M., Wahlgren C., Wahlgren N., Binaghi S., Hirt L., Michel P., Ruchat P., Engelter S.T., Fluri F., Guerke L., Jacob A.L., Kirsch E., Radue E.-W., Stierli P., Wasner M., Wetzel S., Bonvin C., Kalangos A., Lovblad K., Murith N., Ruefenacht D., Sztajzel R., Higgins N., Kirkpatrick P.J., Martin P., Adam D., Bell J., Bradbury A.W., Crowe P., Gannon M., Henderson M.J., Sandler D., Shinton R.A., Scriven J.M., Wilmink T., D'Souza S., Egun A., Guta R., Punekar S., Seriki D.M., Thomson G., Brennan J.A., Enevoldson T.P., Gilling-Smith G., Gould D.A., Harris P.L., McWilliams R.G., Nasser H.-C., and White R.
- Abstract
Background: Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Method(s): The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Finding(s): The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.
- Published
- 2010
18. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
- Author
-
Ederle, Jörg, Dobson, Joanna, Featherstone, Roland L., Bonati, Leo H., van der Worp, H. Bart, de Borst, Gert J., Hauw Lo, T., Gaines, Peter, Dorman, Paul J., Macdonald, Sumaira, Lyrer, Philippe A., Hendriks, Johanna M., McCollum, Charles, Nederkoorn, Paul J., Brown, Martin M., Algra, A., Bamford, J., Bland, M., Hacke, W., Mas, J.L., McGuire, A.J., Sidhu, P., Bradbury, A., Collins, R., Molyneux, A., Naylor, R., Warlow, C., Ferro, M., Thomas, D., Featherstone, R.F., Tindall, H., McCabe, D.J.H., Wallis, A., Coward, L., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, P.G., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, J.M.H., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Verbist, J., Blair, J.-F., Caron, J.L., Daneault, N., Giroux, M.-F., Guilbert, F., Lanthier, S., Lebrun, L.-H., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Albäck, A., Harno, H., Ijäs, P., Kaste, M., Lepäntalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, M.J.W., Reekers, J.A.A., Roos, Y.B.W.E.M., Hendriks, J.M., Koudstaal, P.J., Pattynama, P.M.T., van der Lugt, A., van Dijk, L.C., van Sambeek, M.R.H.M., van Urk, H., Verhagen, H.J.M., Bruijninckx, C.M.A., de Bruijn, S.F., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, F.C., van den Berg, J.S.P., van Hasselt, B.A.A.M., Zeilstra, D.J., Boiten, J., de Mol van Otterloo, J.C.A., de Vries, A.C., Lycklama a Nijeholt, G.J., van der Kallen, B.F.W., Blankensteijn, J.D., De Leeuw, F.E., Schultze Kool, L.J., van der Vliet, J.A., de Kort, G.A.P., Kapelle, L.J., Lo, T.H., Mali, W.P.T.M., Moll, F., Verhagen, H., Barber, P.A., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, S.J., Krohg-Sørensen, K., Skjelland, M., Tennøe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, Jordi, Gimenez Gaibar, A., Perendreu, J., Björses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, T.-B., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Engelter, S.T., Fluri, F., Guerke, L., Jacob, A.L., Kirsch, E., Radue, E.-W., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, P.J., Martin, P., Adam, D., Bell, J., Bradbury, A.W., Crowe, P., Gannon, M., Henderson, M.J., Sandler, D., Shinton, R.A., Scriven, J.M., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, D.M., Thomson, G., Brennan, J.A., Enevoldson, T.P., Gilling-Smith, G., Gould, D.A., Harris, P.L., McWilliams, R.G., Nasser, H.-C., White, R., Prakash, K.G., Serracino-Inglott, F., Subramanian, G., Symth, J.V., Walker, M.G., Clarke, M., Davis, M., Dixit, S.A., Dorman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Mendelow, A.D., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Jäger, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, G.E., Nasim, A., O'Neill, P., Edwards, R.D., Lees, K.R., MacKay, A.J., Moss, J., Rogers, P., Ederle, Jörg, Dobson, Joanna, Featherstone, Roland L., Bonati, Leo H., van der Worp, H. Bart, de Borst, Gert J., Hauw Lo, T., Gaines, Peter, Dorman, Paul J., Macdonald, Sumaira, Lyrer, Philippe A., Hendriks, Johanna M., McCollum, Charles, Nederkoorn, Paul J., Brown, Martin M., Algra, A., Bamford, J., Bland, M., Hacke, W., Mas, J.L., McGuire, A.J., Sidhu, P., Bradbury, A., Collins, R., Molyneux, A., Naylor, R., Warlow, C., Ferro, M., Thomas, D., Featherstone, R.F., Tindall, H., McCabe, D.J.H., Wallis, A., Coward, L., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, P.G., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, J.M.H., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Verbist, J., Blair, J.-F., Caron, J.L., Daneault, N., Giroux, M.-F., Guilbert, F., Lanthier, S., Lebrun, L.-H., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Albäck, A., Harno, H., Ijäs, P., Kaste, M., Lepäntalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, M.J.W., Reekers, J.A.A., Roos, Y.B.W.E.M., Hendriks, J.M., Koudstaal, P.J., Pattynama, P.M.T., van der Lugt, A., van Dijk, L.C., van Sambeek, M.R.H.M., van Urk, H., Verhagen, H.J.M., Bruijninckx, C.M.A., de Bruijn, S.F., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, F.C., van den Berg, J.S.P., van Hasselt, B.A.A.M., Zeilstra, D.J., Boiten, J., de Mol van Otterloo, J.C.A., de Vries, A.C., Lycklama a Nijeholt, G.J., van der Kallen, B.F.W., Blankensteijn, J.D., De Leeuw, F.E., Schultze Kool, L.J., van der Vliet, J.A., de Kort, G.A.P., Kapelle, L.J., Lo, T.H., Mali, W.P.T.M., Moll, F., Verhagen, H., Barber, P.A., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, S.J., Krohg-Sørensen, K., Skjelland, M., Tennøe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, Jordi, Gimenez Gaibar, A., Perendreu, J., Björses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, T.-B., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Engelter, S.T., Fluri, F., Guerke, L., Jacob, A.L., Kirsch, E., Radue, E.-W., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, P.J., Martin, P., Adam, D., Bell, J., Bradbury, A.W., Crowe, P., Gannon, M., Henderson, M.J., Sandler, D., Shinton, R.A., Scriven, J.M., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, D.M., Thomson, G., Brennan, J.A., Enevoldson, T.P., Gilling-Smith, G., Gould, D.A., Harris, P.L., McWilliams, R.G., Nasser, H.-C., White, R., Prakash, K.G., Serracino-Inglott, F., Subramanian, G., Symth, J.V., Walker, M.G., Clarke, M., Davis, M., Dixit, S.A., Dorman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Mendelow, A.D., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Jäger, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, G.E., Nasim, A., O'Neill, P., Edwards, R.D., Lees, K.R., MacKay, A.J., Moss, J., and Rogers, P.
- Abstract
Background: Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods: The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings: The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4·0%) events of disabling stroke or death in the stenting group compared with 27 (3·2%) events in the endarterectomy group (hazard ratio [HR] 1·28, 95% CI 0·77-2·11). The incidence of stroke, death, or procedural myocardial infarction was 8·5% in the stenting group compared with 5·2% in the endarterectomy group (72 vs 44 events; HR 1·69, 1·16-2
- Published
- 2010
19. NCGNP 23rd Annual Convention
- Author
-
Henderson, M.J, primary
- Published
- 2004
- Full Text
- View/download PDF
20. Is 2-D imaging and colour-Doppler alone, without spectral-Doppler, a reliable screening test for carotid stenosis?
- Author
-
Banerjee, A.K., primary, Tudway, D.C., additional, and Henderson, M.J., additional
- Published
- 1997
- Full Text
- View/download PDF
21. Carbon dioxide: An alternative to lodinated contrast media
- Author
-
Yusuf, S.W., primary, Whitaker, S.C., additional, Hinwood, D., additional, Henderson, M.J., additional, Gregson, R.H.S., additional, Wenham, P.W., additional, Hopkinson, B.R., additional, and Makin, G.S., additional
- Published
- 1995
- Full Text
- View/download PDF
22. Anxiety and depression in patients with chronic urticaria and generalized pruritus
- Author
-
LSHEEHAN-DARE, R.A., primary, HENDERSON, M.J., additional, and A.COTTERILL, J., additional
- Published
- 1990
- Full Text
- View/download PDF
23. Case report: Cholesterol embolization following angiography
- Author
-
Henderson, M.J., primary and Manhire, A.R., additional
- Published
- 1990
- Full Text
- View/download PDF
24. Technetium-99m bone scintigraphy and mandibular condylar hyperplasia
- Author
-
Henderson, M.J., primary, Wastie, M.L., additional, Bromige, M., additional, Selwyn, P., additional, and Smith, A., additional
- Published
- 1990
- Full Text
- View/download PDF
25. Extracorporeal circuit design considerations for giant intracranial aneurysm repair.
- Author
-
MacDonald, J.L., Cleland, A.G., Mayer, R.L., and Henderson, M.J.
- Subjects
ARTIFICIAL blood circulation ,INTRACRANIAL aneurysms ,CEREBRAL artery surgery - Abstract
Clinical perfusionists must be able to modify the existing extracorporeal circuit in order to accommodate a specific surgical pathology. The clipping of a giant intracranial middle cerebral artery aneurysm, unapproachable with conventional neurosurgical techniques, required the use of a modified closed cardiopulmonary bypass circuit combined with deep hypothermia and total circulatory arrest. In- hospital discussions with anaesthesia, cardiac surgery, neurosurgery, and cardiology enabled an informed team approach directed towards the successful treatment of this complex neurosurgical lesion. [ABSTRACT FROM AUTHOR]
- Published
- 1997
- Full Text
- View/download PDF
26. Nursing Care Financing: The Limitations
- Author
-
Henderson, M.J.
- Subjects
Nursing homes -- Finance ,Banking, finance and accounting industries ,Business ,Real estate industry - Published
- 1983
27. Validation of cocaine and marijuana effect expectancies in a treatment setting - A 9-year longitudinal study
- Author
-
Galen, L.W. and Henderson, M.J.
- Published
- 1999
- Full Text
- View/download PDF
28. FISH OILS AS MEDICINES
- Author
-
Jones, R.G., primary and Henderson, M.J., additional
- Published
- 1987
- Full Text
- View/download PDF
29. COD LIVER OIL OR BUST
- Author
-
Henderson, M.J., primary and Jones, R.G., additional
- Published
- 1987
- Full Text
- View/download PDF
30. Effect of cobra venom factor on the in vivo immune response in Galleria mellonella to Pseudomonas aeruginosa
- Author
-
Aston, W.P., primary, Chadwick, J.S., additional, and Henderson, M.J., additional
- Published
- 1976
- Full Text
- View/download PDF
31. Regulation of Glucose Uptake in Muscle
- Author
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Morgan, H.E., primary, Henderson, M.J., additional, Regen, D.M., additional, and Park, C.R., additional
- Published
- 1961
- Full Text
- View/download PDF
32. Regulation of Glucose Uptake in Muscle
- Author
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Henderson, M.J., primary, Morgan, H.E., additional, and Park, C.R., additional
- Published
- 1961
- Full Text
- View/download PDF
33. The action of insulin on the transport of glucose through the cell membrane
- Author
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Park, C.R., primary, Reinwein, D., additional, Henderson, M.J., additional, Cadenas, E., additional, and Morgan, H.E., additional
- Published
- 1959
- Full Text
- View/download PDF
34. Obituaries.
- Author
-
Henderson, M.J.
- Subjects
- *
DEAD , *DEATH - Abstract
Presents an obituary for Sean Coyle, senior registrar in chemical pathology at Saint James Hospital in Leeds, England. Career highlights; Achievements.
- Published
- 1997
35. A difficult psychiatric patient
- Author
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Henderson, M.J.
- Published
- 2000
36. A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma
- Author
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Rogier Versteeg, Gian Paolo Tonini, Gudrun Schleiermacher, Amanda J. Russell, Angelika Eggert, Murray D. Norris, Jaydutt Bhalshankar, Michael D. Hogarty, Tom Van Maerken, Glenn M. Marshall, Mark J. Cowley, Kwun M. Fong, Lesley J. Ashton, John M. Maris, Sharon J. Diskin, Michelle Haber, Jayne Murray, Michelle J. Henderson, Stefania Purgato, Raymond L. Stallings, Jan Koster, Paolo Pigini, Ali Rihani, Zalman Vaksman, Jo Vandesompele, Wendy B. London, Rosa Noguera, Emanuele Valli, Laura D. Gamble, Franki Speleman, Federico M. Giorgi, Giovanni Perini, Giorgio Milazzo, Simone Di Giacomo, David S. Ziegler, Oncogenomics, CCA - Cancer biology and immunology, Gamble L.D., Purgato S., Henderson M.J., Di Giacomo S., Russell A.J., Pigini P., Murray J., Valli E., Milazzo G., Giorgi F.M., Cowley M., Ashton L.J., Bhalshankar J., Schleiermacher G., Rihani A., Van Maerken T., Vandesompele J., Speleman F., Versteeg R., Koster J., Eggert A., Noguera R., Stallings R.L., Tonini G.P., Fong K., Vaksman Z., Diskin S.J., Maris J.M., London W.B., Marshall G.M., Ziegler D.S., Hogarty M.D., Perini G., Norris M.D., and Haber M.
- Subjects
0301 basic medicine ,Cancer Research ,SNP ,Single-nucleotide polymorphism ,Biology ,lcsh:RC254-282 ,Article ,Ornithine decarboxylase ,03 medical and health sciences ,neuroblastoma ,Neuroblastoma ,0302 clinical medicine ,Genotype ,MYCN ,Medicine and Health Sciences ,Transcriptional regulation ,medicine ,ODC1 ,neoplasms ,Wild type ,Promoter ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Molecular biology ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Childhood Neuroblastoma - Abstract
Simple Summary Neuroblastoma is a devasting childhood cancer in which multiple copies (amplification) of the cancer-causing gene MYCN strongly predict poor outcome. Neuroblastomas are reliant on high levels of cellular components called polyamines for their growth and malignant behavior, and the gene regulating polyamine synthesis is called ODC1. ODC1 is often coamplified with MYCN, and in fact is regulated by MYCN, and like MYCN is prognostic of poor outcome. Here we studied a naturally occurring genetic variant or polymorphism that occurs in the ODC1 gene, and used gene editing to demonstrate the functional importance of this variant in terms of ODC1 levels and growth of neuroblastoma cells. We showed that this variant impacts the ability of MYCN to regulate ODC1, and that it also influences outcome in neuroblastoma, with the rarer variant associated with a better survival. This study addresses the important topic of genetic polymorphisms in cancer. Ornithine decarboxylase (ODC1), a critical regulatory enzyme in polyamine biosynthesis, is a direct transcriptional target of MYCN, amplification of which is a powerful marker of aggressive neuroblastoma. A single nucleotide polymorphism (SNP), G316A, within the first intron of ODC1, results in genotypes wildtype GG, and variants AG/AA. CRISPR-cas9 technology was used to investigate the effects of AG clones from wildtype MYCN-amplified SK-N-BE(2)-C cells and the effect of the SNP on MYCN binding, and promoter activity was investigated using EMSA and luciferase assays. AG clones exhibited decreased ODC1 expression, growth rates, and histone acetylation and increased sensitivity to ODC1 inhibition. MYCN was a stronger transcriptional regulator of the ODC1 promoter containing the G allele, and preferentially bound the G allele over the A. Two neuroblastoma cohorts were used to investigate the clinical impact of the SNP. In the study cohort, the minor AA genotype was associated with improved survival, while poor prognosis was associated with the GG genotype and AG/GG genotypes in MYCN-amplified and non-amplified patients, respectively. These effects were lost in the GWAS cohort. We have demonstrated that the ODC1 G316A polymorphism has functional significance in neuroblastoma and is subject to allele-specific regulation by the MYCN oncoprotein.
- Published
- 2021
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