1. Adult Neurogenesis Produces Neurons with Unique GABAergic Synapses in the Olfactory Bulb.
- Author
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Valley, Matthew T., Henderson, Lansdale G., Inverso, Samuel A., and Lledo, Pierre-Marie
- Subjects
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OLFACTORY bulb , *DEVELOPMENTAL neurobiology , *NEURONS , *SYNAPSES , *BRAIN research , *CYTOPLASMIC granules - Abstract
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic targeting of specific neuronal ages. We find that adult-born interneurons are resistant to presynapticGABAB-mediated depression of GABA release compared with interneurons born just after birth that exhibit strong GABAB neuromodulation. Correlated with this functional change, we found altered localization of the GABABR1 protein within adult-born granule cells. These results suggest that adult neurogenesis produces a population of functionally unique GABAergic synapses in the olfactory bulb. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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