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508 results on '"Henderson, Kim A."'

2. Germany’s far right scores a win.

Author

Schmitt, Jenny Lind, Snell, Grace, Russell, Elizabeth, Oduah, Onize, Páez, Carlos, McCallum, Bekah, Vician, Todd, Offereins, Addie, and Henderson, Kim

Subjects
WORLD War II, POLITICAL parties, ELECTIONS, VOTING
Published
2024

3. Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low‐Risk Modalities?

Author

Qu, Yusheng, Henderson, Kim A., Harper, Tod A., and Vargas, Hugo M.

Subjects
INTERVAL analysis, BASE pairs, CHEMICAL properties, DATABASES, GENE expression, MONOCLONAL antibodies, CONFERENCES & conventions
Abstract

Oligonucleotide therapeutics (ONTs) represent a new modality with unique pharmacological and chemical properties that modulate gene expression with a high degree of target specificity mediated by complementary Watson‐Crick base pair hybridization. To date, the proarrhythmic assessment of ONTs has been influenced by International Conference on Harmonization (ICH) E14 and S7B guidance. To document current hERG/QTc evaluation practices, we reviewed US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Approval Packages (source: PharmaPendium.com) and collated preclinical and clinical studies for 17 marketed ONTs. In addition, clinical QTc data from 12 investigational ONTs were obtained from the literature. Of the marketed ONTs, eight were tested in the hERG assay with no inhibitory effect identified at the top concentration (range: 34–3,000 μM) tested. Fourteen of the ONTs were evaluated in nonhuman primate cardiovascular studies with 11 of them in dedicated telemetry studies. No effect on QTc intervals were observed (at high exposure multiples) in all studies. Clinically, four ONTs were evaluated in TQT studies; an additional six ONTs were assessed by concentration‐QTc interval analysis, and six by routine safety electrocardiogram monitoring. None of the clinical studies identified a QTc prolongation risk; the same was true for the 12 investigational ONTs. A search of the FDA Adverse Event Database indicated no association between approved ONTs and proarrhythmias. Overall, the collective weight of evidence from 29 ONTs demonstrate no clinical proarrhythmic risk based on data obtained from ICH S7B/E14 studies. Thus, new ONTs may benefit from reduced testing strategies because they have no proarrhythmic risk, a similar cardiac safety profile as monoclonal antibodies, proteins, and peptides. [ABSTRACT FROM AUTHOR]

Published
2024
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5. WORK IN PROGRESS.

Author

HENDERSON, KIM

Subjects
*POWERLINE technicians, *FEDERAL aid to education, *SHEET metal work, *YOUNG adults, *DIAGNOSTIC ultrasonic imaging personnel
Abstract

This article explores the benefits and challenges of apprenticeship programs in the United States. It highlights the success of Ingalls Shipbuilding in offering registered apprenticeships and emphasizes the advantages of earning a salary while gaining valuable on-the-job experience. The article also discusses the need for a shift in the American education system to prioritize apprenticeships and mentions the government's interest in promoting these programs. It addresses concerns raised by industry experts regarding new rules that add barriers to establishing apprenticeships and emphasizes the importance of funding and government support. The article concludes by sharing the experiences of apprentices at Ingalls Shipbuilding and their career advancement opportunities. INSET: PURPOSE-DRIVEN WORK.. [Extracted from the article]

Published
2024

6. Bangladesh: job-seekers vs. government.

Author

Lewis, Amy, Páez, Carlos, Wu, Joyce, Russell, Elizabeth, McCallum, Bekah, Lamer, Tim, Offereins, Addie, and Henderson, Kim

Subjects
STATE laws, GOVERNMENT policy, MEDICAL personnel, CRIMES against LGBTQ+ people, OFFENSES against the person
Abstract

In Bangladesh, protests have erupted over the government's job policy, leading to the resignation of Prime Minister Sheikh Hasina and violent clashes resulting in several deaths. The protests were sparked by a quota system that reserved one-third of government jobs for descendants of fighters in the 1971 war for independence. Students claimed that the rule unfairly benefited members of Hasina's party. In Australia, pediatric hospitals are planning to give babies with peanut allergies a daily dose of peanut powder in an effort to reduce the chance of life-threatening reactions. The previous standard of care required allergic children to avoid peanuts altogether, but doctors hope that early exposure to the allergen will force the allergy into remission. [Extracted from the article]

Published
2024

10. OVERTURE TO HARMONY: A YOUNG COMPOSER FINDS HIS RHYTHM IN THE WORLD OF MODERN MUSIC.

Author

HENDERSON, KIM

Subjects
*CONTEMPORARY classical music, *MUSICAL composition, *MUSIC education, *COMPOSERS, *HARMONY in music
Abstract

This article tells the story of Elliot Butler, a young composer who has pursued his dream of composing grand orchestral music. Despite the challenges of the modern classical music industry and the push towards more dissonant and unconventional styles, Butler remains committed to creating music that reflects his Biblical worldview and pleases the ear and soul. He has faced obstacles as a Caucasian male in a field that prioritizes underrepresented voices, but he remains dedicated to his craft and recently had his work performed by the Illinois Valley Symphony Orchestra. [Extracted from the article]

Published
2024

11. MORE CRIME, LESS PUNISHMENT: Bankrolled by activist billionaires, progressive prosecutors upend the justice system and unravel the rule of law.

Author

HENDERSON, KIM

Subjects
*JUSTICE administration, *CRIME, *RULE of law, *BURGLARY, *PROSECUTORS, *ACTIVISTS
Abstract

This article explores the influence of wealthy individuals, like George Soros, in supporting progressive prosecutors in different cities in the United States. These prosecutors, such as Larry Krasner and Kim Foxx, have been praised for their progressive policies, but critics argue that their leniency on crime has resulted in an increase in violence and a lack of respect for the rule of law. The article provides specific cases and examples where these prosecutors have faced criticism for their approaches. It also emphasizes the significance of the rule of law and the importance of prosecutors prioritizing justice over personal beliefs. [Extracted from the article]

Published
2024

19. Supplementary Figure 1 from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

Author

Chng, Wee J., primary, Kumar, Shaji, primary, VanWier, Scott, primary, Ahmann, Greg, primary, Price-Troska, Tammy, primary, Henderson, Kim, primary, Chung, Tae-Hoon, primary, Kim, Seungchan, primary, Mulligan, George, primary, Bryant, Barbara, primary, Carpten, John, primary, Gertz, Morie, primary, Rajkumar, S. Vincent, primary, Lacy, Martha, primary, Dispenzieri, Angela, primary, Kyle, Robert, primary, Greipp, Philip, primary, Bergsagel, P. Leif, primary, and Fonseca, Rafael, primary

Published
2023
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20. Supplementary Figure 3 from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

Author

Chng, Wee J., primary, Kumar, Shaji, primary, VanWier, Scott, primary, Ahmann, Greg, primary, Price-Troska, Tammy, primary, Henderson, Kim, primary, Chung, Tae-Hoon, primary, Kim, Seungchan, primary, Mulligan, George, primary, Bryant, Barbara, primary, Carpten, John, primary, Gertz, Morie, primary, Rajkumar, S. Vincent, primary, Lacy, Martha, primary, Dispenzieri, Angela, primary, Kyle, Robert, primary, Greipp, Philip, primary, Bergsagel, P. Leif, primary, and Fonseca, Rafael, primary

Published
2023
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21. Supplementary Tables 1-8 from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

Author

Chng, Wee J., primary, Kumar, Shaji, primary, VanWier, Scott, primary, Ahmann, Greg, primary, Price-Troska, Tammy, primary, Henderson, Kim, primary, Chung, Tae-Hoon, primary, Kim, Seungchan, primary, Mulligan, George, primary, Bryant, Barbara, primary, Carpten, John, primary, Gertz, Morie, primary, Rajkumar, S. Vincent, primary, Lacy, Martha, primary, Dispenzieri, Angela, primary, Kyle, Robert, primary, Greipp, Philip, primary, Bergsagel, P. Leif, primary, and Fonseca, Rafael, primary

Published
2023
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22. Supplementary Methods from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

Author

Chng, Wee J., primary, Kumar, Shaji, primary, VanWier, Scott, primary, Ahmann, Greg, primary, Price-Troska, Tammy, primary, Henderson, Kim, primary, Chung, Tae-Hoon, primary, Kim, Seungchan, primary, Mulligan, George, primary, Bryant, Barbara, primary, Carpten, John, primary, Gertz, Morie, primary, Rajkumar, S. Vincent, primary, Lacy, Martha, primary, Dispenzieri, Angela, primary, Kyle, Robert, primary, Greipp, Philip, primary, Bergsagel, P. Leif, primary, and Fonseca, Rafael, primary

Published
2023
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23. Supplementary Figure 2 from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

Author

Chng, Wee J., primary, Kumar, Shaji, primary, VanWier, Scott, primary, Ahmann, Greg, primary, Price-Troska, Tammy, primary, Henderson, Kim, primary, Chung, Tae-Hoon, primary, Kim, Seungchan, primary, Mulligan, George, primary, Bryant, Barbara, primary, Carpten, John, primary, Gertz, Morie, primary, Rajkumar, S. Vincent, primary, Lacy, Martha, primary, Dispenzieri, Angela, primary, Kyle, Robert, primary, Greipp, Philip, primary, Bergsagel, P. Leif, primary, and Fonseca, Rafael, primary

Published
2023
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26. The world needs Canada's energy. Does Canada want to help?

Author

Greenspon, Edward, Henderson, Kim, and Nikolejsin, Dave

Subjects
Liquefied natural gas -- Supply and demand, Company business planning, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Byline: EDWARD GREENSPON, KIM HENDERSON, DAVE NIKOLEJSIN Edward Greenspon is president and CEO of the Public Policy Forum, former editor-in-chief of The Globe and Mail and former global managing editor [...]

Published
2022

32. DEPRAVED HEARTS.

Author

HENDERSON, KIM

Subjects
*CRIME, *MURDER, *MANSLAUGHTER
Published
2023

41. New DA in town.

Author

HENDERSON, KIM, Jackson, Mary, Vician, Todd, Lewis, Amy, Oduah, Onize, and Palumbo, Elisa

Subjects
*HUMAN beings, *GOVERNMENTAL investigations, *MINORS, *DEMOCRATS (United States), *REPUBLICANS, *KIDNAPPING
Published
2024

42. Utah: Mormons on a building spree.

Author

Canterberry, Lauren, Henderson, Kim, Vician, Todd, Russell, Elizabeth, and Jackson, Mary

Subjects
*CARBON sequestration, *HOUSING, *LOW-income housing, *VETERANS, *CARBON emissions, *VIOLENT crimes
Published
2024

44. Efeitos do montelucaste de sódio sobre polarização de macrófagos durante reparo ósseo pós exodontia em camundongos

Author

Henderson, Kim

Abstract

Esse trabalho tem como objetivo avaliar a influência do MTK sobre a polarização de macrófagos expressos durante o reparo alveolar em camundongos 129Sv/Ev machos jovens, nos períodos de 7, 14 e 21 dias pós-exodontia. Para isso, serão utilizados 63 camundongos machos, com idade aproximada de 16 semanas, peso médio de 25 gramas, a serem divididos em três grupos: C - Grupo Controle (não tratados); MTK2 – 2 mg/kg de MTK e MTK4 – 4 mg/kg de MTK. Os animais dos grupos MTK2 e MTK4 serão tratados diariamente por via oral, iniciando 24 horas antes do procedimento cirúrgico, continuando até o final dos períodos experimentais de 7, 14 e 21 dias pós- operatórios. Ao final dos períodos determinados, os animais serão submetidos à eutanásia para obtenção da maxila direita juntamente com os alvéolos extraídos, para análises histopatológicas, bem como análises imuno-histoquímicas para os marcadores de enzimas COX-2 e 5-LO, diferenciação osteoclástica (RANKL), macrófagos F4/80, bem como perfis de macrófagos polarizados para M2 (CD163 e TGF-ß) e M1 (CD80). Posteriormente, as células marcadas serão quantificadas por meio de análise histomorfométrica e submetidas testes estatísticos considerando- se nível de significância de 5%. Ao final deste estudo, espera-se contribuir para o melhor entendimento do potencial terapêutico do montelucaste de sódio sobre a modulação do processo inflamatório durante o reparo ósseo alveolar, bem como elucidar a influência da do receptor CisLTR-1 nos diferentes subtipos celulares analisados.

Published
2022
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45. Ecuador's deadly election.

Author

Russell, Elizabeth, Wu, Joyce, Snell, Grace, Lewis, Amy, Ohikere, Onize, Schmitt, Jenny Lind, Lumetta, Carolina, Henderson, Kim, Vician, Todd, and Freire, Emma

Subjects
ELECTIONS, UNITED States presidential election, 2020, PRETRIAL release, CONSPIRACY, HEAT waves (Meteorology)
Published
2023

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