Search

Your search keyword '"Henaoui IS"' showing total 137 results
Start Over Author "Henaoui IS"
137 results on '"Henaoui IS"'

1. Description d’un sous-groupe de patients avec glomérulonéphrite rapidement progressive à ANCA anti-MPO associée à un infiltrat tubulo-interstitiel à plasmocytes IgG4+

Author

Delcros, Q., primary, Ursule-Dufait, C., additional, Karras, A., additional, Ulrich, M., additional, Guilpain, P., additional, Brilland, B., additional, Groh, M., additional, Piette, J.C., additional, Outh, R., additional, Zaidan, M., additional, Henaoui, B., additional, Ebbo, M., additional, Mouthon, L., additional, Duong Van Huyen, J.P., additional, and Terrier, B., additional

Published
2024
Full Text
View/download PDF

2. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Abbassi, Abdelhamid, Debure, Alain, Guerraoui, Abdallah, Benmoussa, Abdelatif, Hamani, Abdelaziz, Ziane, Abdelaziz, Nefti, Abdelhamid, Hadj, Abdelkader, El Amari, Abderrahim, Ghazali, Abderrahmane, Abd El Fatah Mohamed, Abo Bakr, Laradi, Achour, Ben Ahmed, Adel, Sahar, Adel, Pillet, Adele, Lacraz, Adeline, Moinat, Adnan, Massoumi, Afshin, Pardon, Agathe, Beaudoin, Agnes Caillette, Debout, Agnes Chapelet, Mariot, Agnes, Rachi, Ahmed, Afiani, Aida, Boula, Aime Remy, Jalaby, Al, Cremault, Alain, Fournier, Alain, Jeanson, Alain, Lyon, Alain, Nony, Alain, Robert, Alain, Slingeneyer, Alain, Labatide, Alanor Agnes, Sartorius, Albane Brodin, Bensman, Albert, Fournier, Albert, Ranlin, Alex, Sandor, Alex Vido, Colombo, Alexandra, Duhem, Alexandra, Stancu, Alexandra, Dufay, Alexandre, Dumoulin, Alexandre, Ebel, Alexandre, Klein, Alexandre, Martin, Alexandre, Mouneimne, Alexandre, Seidowsky, Alexandre, De Martin, Alfio, Zannier, Alfredo, Aizel, Ali, Hafi, Ali, Diddaoui, Ali Zineddine, Heyani, Alim, Mocanu, Alina, Preda, Alina, Hafi, Aline, Talaszka, Aline, Duquesne, Alyette, Amaouche, Amar, Ghemmour, Amel, Simon, Amelie, Skalli, Amina, Boukadida, Amine, Ragab Eid, Amr Ekhlas, Fedorca, Ana, Baillet, Anabelle, Poyet, Anais, Giorgita, Ancuta Bouffandeau, Ratsimbazafy, Anderson, Pruna, Andre, Argiles, Angel, Testa, Angelo, Vandooren, Ann Karolien, Jolivot, Anne, Labadens, Anne Kolko, Lataste, Anne, Maisin, Anne, Paris, Anne, Sechet, Anne, Wuillai, Anne, Heng, Anne Elisabeth, Josse, Anne Gaelle, Querard, Anne Helene, Reboux, Anne Helene, Adra, Anne Laure, Faller, Anne Laure, Leclerc, Anne Laure, Poitou, Anne Laure, Manucci, Annie Lahoche, Jacquet, Antoine, Pommereau, Antoine, Thierry, Antoine, Adem, Arezki, Chapelet, Arielle, Del Bello, Arnaud, Delezire, Arnaud, Garnier, Arnaud, Guerard, Arnaud, Klisnick, Arnaud, Lionet, Arnaud, Roccabianca, Arnaud, Stolz, Arnaud, Capdeville, Arthur, Allal, Asma, Alrifai, Assem, Diarrassouba, Assetou, Djema, Assia, Carre, Assia Ferhat, Dubrasquet, Astrid Godron, Elmrabet, Atman Haddj, Jegado, Audrey, Thomas, Aurelia Bertholet, Salandre, Aurelie Davourie, Pajot, Aurelie, Lorthioir, Aurelien, Tiple, Aurelien, Sury, Aurore, Abokasem, Ayman, Sarraj, Ayman, Henaoui, Bachir, Chaghouri, Baher, Wehbe, Bassem, Ball, Beatrice, Viron, Beatrice, Issad, Belkassem, Corne, Benedicte Hodemon, Janbon, Benedicte, Deroure, Benjamin, Savenkoff, Benjamin, Jonon, Benoit, Vendrely, Benoit, Djelaleddine, Benyakoub, Ohry, Bernard, Painchart, Bernard, Strullu, Bernard, Temperville, Bernard, Ebikili, Bertin, Hacq, Bertrand, Morel, Bertrand, Aoun, Bilal, Muniz, Blanca, Chlih, Bouchra, Amara, Brahim, Mayor, Brice, Gilson, Brigitte, Llanas, Brigitte, Zins, Brigitte, Bourgeon, Bruno, Coevoet, Bruno, Guery, Bruno, Legallicier, Bruno, Paris, Bruno, Ranchin, Bruno, Seigneuric, Bruno, Dita, Camelia Ghiciuc, Prelipcean, Camelia, Hottelart, Carine Achard, Diet, Carine, Frangie, Carlos, Vela, Carlos, Muresan, Carmina, Deprele, Carole, Araujo, Caroline, Bidault, Caroline, Creput, Caroline, Delclaux, Caroline, Du Halgouet, Caroline, Favennec, Caroline, Freguin, Caroline, Vercel, Caroline Gourraud, Mesguen, Caroline, Obama, Caroline Ndomo, Poitou, Caroline, Dirhold, Caroline Preissig, Roubiou, Caroline, Albert, Catherine, Bessin, Catherine, De Marion Gaja, Catherine, Godart, Catherine, Lasseur, Catherine, Leocardi, Catherine, Lumbroso, Catherine, Melander, Catherine, Michel, Catherine, Maurouard, Catherine Quere, Rouannet, Catherine, Taddei, Catherine, Verove, Cathy, Guiraud, Cecile, Tafelin, Cecile, Baron, Cecile Turc, Formet, Cedric, Pinier, Cedric, De Ste Foy, Celia Lessore, Granolleras, Celine, Bennini, Chaouki, Cartou, Charles, Chazot, Charles, Jouzel, Charlotte, Badid, Cherif, Roubicek, Christa, Viaud, Christel, Verrier, Christelle, Chuet, Christian, Combe, Christian, Dabot, Christian, Duvic, Christian, Emond, Christian, Lagarde, Christian, Lamotte, Christian, Pain, Christian, Mousson, Christiane, Lorriaux, Christie, Beauchamp, Christine, Fumeron, Christine, Le Gurun, Christine, Leroy, Christine, Pietrement, Christine, Richer, Christine, Bouaka, Christophe, Charasse, Christophe, Goupy, Christophe, Ridel, Christophe, Castrale, Cindy, Detourne, Cindy, Francois, Clair, Presne, Claire, Trivin, Claire, Von Kotze, Clarissa, Bernard, Claude, Bonniol, Claude, Desvergnes, Claude, Raharivelina, Claude, Nistor, Claudia, Gueret, Claudine, Lloret, Claudine, Saltiel, Claudine, Rosati, Clelia, Rabate, Clementine, Stanescu, Corina, Ferrandini, Corinne, Guibergia, Corinne, Lemoine, Corinne, Passeron, Corinne, Kahil, Cynthia, Garrouste, Cyril, Van, Cyril Vo, Jolimoy, Cyrille, Kesraoui, Dalila, Jolly, Damien, Thibaudin, Damien, Teboulle, Dan, Daubresse, Daniel, Louvet, Daniel, Rasamimanantsoa, Daniel, Toledano, Daniel, Babici, Daniela, David, Daniela, Dincu, Daniela, Bruno, Danielle, May, Delia, Haussaire, Delphine, Viprey, Delphine Henriet, Bugnon, Denis, Fouque, Denis, Morin, Denis, Nour, Derradji, Mahmoud, Diab Mohamed, Cristescu, Diana Istrati, Aguilera, Didier, Coste, Didier, Hamel, Didier, Le Chapois, Didier, Testou, Didier, Erbilgin, Dilaver, Dahmane, Djamal, Quang, Doan Bui, Bertrand, Dominique, Besnier, Dominique, Blanchier, Dominique, Briffa, Dominique, Caux, Dominique, Durand, Dominique, Fleury, Dominique, Guerrot, Dominique, Hestin, Dominique, Jaubert, Dominique, Joly, Dominique, Lombart, Dominique, Pagniez, Dominique, Pierre, Dominique, Schohn, Dominique, Ikonga, Donatien, Visanica, Dorina, Bazin, Dorothee, Boury, Edouard, Maksour, Edouard, Agbonon, Ekoue, Harrami, Elarbi, Marcu, Elena, Tudorache, Elena, Caniot, Elisabeth, Semjen, Elisabeth, Tomkiewicz, Elisabeth, Scheidt, Elise, Gaboriau, Elke, Lamouroux, Elodie, Guiard, Elsa, Passos, Elsa Martin, Nsembani, Emerson, Fache, Emilie, Kalbacher, Emilie, Pambrun, Emilie, Pincon, Emilie, Launay, Emma Allain, Baron, Emmanuel, Dupuis, Emmanuel, Villar, Emmanuel, Charlin, Emmanuelle, Hecquet, Emmanuelle, Kohler, Emmanuelle, Laurain, Emmanuelle, Rosier, Emmanuelle, Figueroa, Enrique, Azoulay, Eric, Canivet, Eric, Daugas, Eric, Gauthier, Eric, Laruelle, Eric, Le Guen, Eric, Legrand, Eric, Moumas, Eric, Postec, Eric, Prinz, Eric, Renaudineau, Eric, Desport, Estelle, Sutra, Estelle Ricard, Berard, Etienne, Ged, Etienne, Robin, Etienne, Vilaine, Eve, Bargas, Evelyne, Namara, Evelyne Mac, Combarnous, François, Yazbeck, Fatima, Gerard, Fabien, Metivier, Fabien, Parazols, Fabien, Soulis, Fabien, Garnier, Fabrice, Messaoudene, Fadhila Pech, Haidar, Fadi, Boullenger, Fanny, Lepeytre, Fanny, Leroy, Fanny, Frejate, Fares, Bellahsene, Farid, Bellhasene, Farid, Saidani, Farid, Toure, Fatouma, Kriaa, Faycal, Nemmar, Fazia, Vetromile, Fernando, Chalmin, Florence, Lucats, Florence, Sens, Florence, Villemain, Florence, Plasse, Florent, Lebhour, Fouad, Schillinger, Francis, Berge, Franck, Bourdon, Franck, Bridoux, Franck, Reynaud, Franck, Babinet, Francois, Basse, Francois, Chantrel, Francois, Clair, Francois, Coulomb, Francois, De Cornelissen, Francois, Glowacki, Francois, Marchal, Francois, Maurice, Francois, Nobili, Francois, Pourreau, Francois, Provot, Francois, Amani, Francois Roux, Broux, Francoise, Bulte, Francoise, Heibel, Francoise, Leonetti, Francoise, Schott, Francoise Moussion, Le Roy, Frank, Besson, Frederic, Lavainne, Frederic, Tollis, Frederic, Bocquentin, Frederique, Meeus, Frederique, Vecina, Frederique, Von Ey, Friederike, Balit, Gabriel, Choukroun, Gabriel, Gruget, Gabriel, Huchard, Gabriel, Golea, Gabriella, Duneau, Gabrielle, Lefrancois, Gaelle, Pelle, Gaelle, Lebrun, Gaetan, Dumont, Genevieve, Brillet, Georges, Deschenes, Georges, Mourad, Georges, Stamatakis, Georges, Cazajous, Geraldine, D'ythurbide, Geraldine, Wiart, Geraldine Robitaille, Cardon, Gerard, Champion, Gerard, Deschodt, Gerard, Mangenot, Gerard, Motte, Gerard, Schortgen, Gerard, Boulahia, Ghada, Maakaroun, Ghassan, Michel, Ghylene Bourdat, Zanetta, Gilbert, Hufnagel, Gilles, Messier, Gilles, Piccoli, Giorgina, Desvergnes, Gregoire Couvrat, Bobrie, Guillaume, Bonnard, Guillaume, Clement, Guillaume, Jean, Guillaume, Queffeulou, Guillaume, Seret, Guillaume, Vernin, Guillaume, Delavaud, Guy, Lambrey, Guy, Rostoker, Guy, Poussard, Gwenaelle, Kesler, Gwenaelle Roussey, Leon, H., Aboubekr, Habib, Boulechfar, Hacene, Sekhri, Hacene, Hebibi, Hadia, Benalia, Hadjira, Fessi, Hafed, Atchia, Hafsabhai, Bittar, Haiat, Maiza, Hakim, Mazouz, Hakim, El Ali, Hamid, Bougrida, Hammouche, Van Der Pijl, Hans, Lokmane, Hassan, Izzedine, Hassane, Adda, Hassen, De Preneuf, Helene, Leray, Helene, Philippot, Helene, Boulanger, Henri, Merault, Henri, Renaud, Henri, Bonarek, Herve, Maheut, Herve, Nzeyimana, Hilaire, Mehama, Hocine, Zaidi, Hocine, Weclawiak, Hugo, Flodrops, Hugues, Karaaslan, Huseyin, Haskour, Ibrahim, Belhadj, Ihssen, Almoubarak, Imad, Haddad, Imad, Castellano, Ines, Ferrandiz, Ines, Daniliuc, Ioana, Darie, Ioana, Enache, Ioana, Prunescu, Ionut, Djiconkpode, Irenee, Shahapuni, Irina, Bouchoule, Isabelle, Devriendt, Isabelle, Kazes, Isabelle, Kolb, Isabelle, Landru, Isabelle, Poli, Isabelle, Rey, Isabelle, Segalen, Isabelle, Selcer, Isabelle, Vernier, Isabelle, Vrillon, Isabelle, Guenifi, Ismahane, Gheerbrandt, J. Dominique, Potier, Jacky, Becart, Jacques, Cledes, Jacques, Ducros, Jacques, Duvic, Jacques, Fourcade, Jacques, Gaultier, Jacques, Jurine, Jacques, Lebleu, Jacques, Ollier, Jacques, Charles, Jacques Ibsen, Yazji, Jamal, Mansour, Janette, Arnautou, Jean, Brocard, Jean, Carolfi, Jean, Montoriol, Jean, Gouin, Jean Baptiste, Palcoux, Jean Bernard, Bendini, Jean Christophe, Aldigier, Jean Claude, Alphonse, Jean Claude, Delbet, Jean Daniel, Bonne, Jean Francois, Cantin, Jean Francois, De Fremont, Jean Francois, Dessassis, Jean Francois, Subra, Jean Francois, Valentin, Jean Francois, Verdier, Jean Francois, Dion, Jean Jacques, Haultier, Jean Jacques, Montseny, Jean Jacques, Bacri, Jean Louis, Bouchet, Jean Louis, Mahe, Jean Luc, Chalopin, Jean Marc, Gabriel, Jean Marc, Hurot, Jean Marc, Lanau, Jean Marc, Batho, Jean Marie, Coulibaly, Jean Marie, Hardin, Jean Michel, Marc, Jean Michel, Poux, Jean Michel, Rebibou, Jean Michel, Tivollier, Jean Michel, Ottavioli, Jean Noel, Faucon, Jean Paul, Imiela, Jean Paul, Jaulin, Jean Paul, Masselot, Jean Paul, Ortiz, Jean Paul, Bourdenx, Jean Philippe, Devaux, Jean Philippe, Hammelin, Jean Philippe, Rivory, Jean Pierre, Wauquier, Jean Pierre, Larue, Jean Rene, Mondain, Jean Rene, Borde, Jean Sebastien, Virot, Jean Simon, Bosc, Jean Yves, Achiche, Jedjiga, Parasote, Jennifer, Diolez, Jeremie, Harambat, Jerome, Potier, Jerome, Sampol, Jerome, Mustel, Jihad, Lefevre, Jean Jacques, Maurizi, Jocelyne, Gamberoni, Joel, Claudeon, Joelle, Terzic, Joelle, Rogol, Joffrey, Sayegh, Johnny, Cardozo, Jorge, Brasseur, Jose, Guiserix, Jose, Barsumau, Joseph, Albaret, Julie, Beaume, Julie, Attias, Julie Sohier, Dehay, Julien, Hogan, Julien, Journet, Julien, Ott, Julien, Baleynaud, Juliette, Bacchetta, Justine, Faucher, Justine, Yousfi, Kamel, Dardim, Karim, Clabault, Karine, Moreau, Karine, Thomas, Kedna, Sirajedine, Khaled, Chedid, Khalil, El Kaeoui, Khalil, El Karoui, Khalil, Bouachi, Khedidja, Hue, Kheira, El Nasser, Khuzama, Akposso, Kodso, Kunz, Kristian, Bijak, Krzysztof, Kihal, Lilia, Rasoloarijaona, L., Harbouche, Laid, Bencheikh, Larbi, Lamriben, Larbie, Hanafi, Latifa, Parvez, Laura Braun, Champion, Laure, Croze, Laure, Eprinchard, Laure, Patrier, Laure, Nicolet, Laurence, Vrigneaud, Laurence, Duflot, Laurent, Mackaya, Leandre, Chenine, Leila, Odry, Leon, Tamiji, Lili Taghipour, Bouzar, Lilia Antri, Nga Messi, Liliane Ngango, Le Mouellic, Lionel, Mandart, Lise, Weis, Lise, Pouteau, Lise Marie, Georgieva, Lora, Vitanova, Lorita, Chalabi, Lotfi, Delvallez, Luc, Frimat, Luc, Fromentin, Luc, Marty, Luc, Monjot, Luc, Spataru, Luciana, Bessenay, Lucie, Boissinot, Lucie, Wajsbrot, Lucie, Rakoff, Lucien, Lebourg, Ludivine, Perez, Lydie, Lafage, Lyliane, Azzouz, Lynda, Dumoulin, Madeleine, Ouziala, Messaoud, Joseph, Maan, Brahimi, Mabrouk, Fat, Maeva Wong, Fort, Magalie, Nakhla, Magued, Abtahi, Mahdi, Albadawy, Mahen, Alouach, Mahmoud, Mezghani, Mahmoud, Daroux, Maite, Boukelmoune, Maklouf, Dhib, Malek, Touam, Malik, Dubau, Malina, Balde, Mamadou, Khoa, Man Nguyen, Ismer, Manfred, Mehdi, Manolie, Laforet, Manon, Bouiller, Marc, Eugene, Marc, Fila, Marc, Hazzan, Marc, Kribs, Marc, Ladriere, Marc, Lebot, Marc, Padilla, Marc, Souid, Marc, Marraoui, Marcel, Burbach, Maren, Manescu, Maria, Noguera Gonzalez, Maria Eugenia, Revenco, Mariana, Terrasse, Marianne, Essi, Marie, Macher, Marie Alice, Nogier, Marie Beatrice, Cazin, Marie Cecile, Schweitzer Camoin, Marie Christine, Thouret, Marie Christine, Hannaert, Marie Claude, Servel, Marie France, Chabannier, Marie Helene, Coudert Krier, Marie Jeanne, Catoliquot, Marie Noelle, Guillodo, Marie Paule, Gavard, Marie Sophie, Vairon Codaccioni, Marie Xaviere, Rabec, Marina, Freist, Marine, Gauthier, Marion, Lemaire, Marion, Mehrenberger, Marion, Venot, Marion, Pongas, Marios, Diant, Marlene Beaubrun, Levannier, Martial, Bertaux, Martine, Jablonski, Mathieu, Sacquepee, Mathieu, Dargelos, Mathilde, Lemoine, Mathilde, Tamain, Mathilde, Monge, Matthieu, Reberolle, Matthieu, Cousin, Maud, Francois, Maud, Baron, Maurice, Hoffmann, Maxime, Ingwiller, Maxime, Touzot, Maxime, Mohajer, Mederick, Maaz, Mehadji, Hanoy, Melanie, Marroc, Melanie, Cuny, Melodie, Van Der Straaten, Menno, Serveaux, Mf., Basteri, Michel, Chong, Michel Fen, Hecht, Michel, Massad, Michel, Normand, Michel, Olmer, Michel, Tolani, Michel, Tsimaratos, Michel, Hemery, Michele, Kessler, Michele, Esposito, Miguel, Shenouda, Milad, Kareche, Mimi, Khalili, Mina, Diaconita, Mirella, Rifard, Mohamad Khair, Aladib, Mohamed, Belmouaz, Mohamed, Brahim, Mohamed, Diouani, Mohamed, Cherif, Mohamed Fodil, Jamali, Mohamed, Maghlaoua, Mohamed, Meddeb, Mohamed, Ramdane, Mohamed, Rifaat, Mohamed, Islam, Mohamed Sharifull, Abbade, Mohamed Adnan, Amrandi, Mokhtar, Chawki, Mokhtar, Ciobotaru, Monica, Indrieis, Monica, Chanas, Monique, Hoarau, Monique, Tomeh, Monzer, Bellou, Moufida, Bouzernidj, Mouloud, Ammor, Mounia, Guergour, Mounir, Benzakour, Mountassir, Hachicha, Mourad, Coulibaly, Moussa, Smati, Mustafa, Al Morabiti, Mustapha, Amirou, Mustapha, Isnard, Myriam, Pastural, Myriam, Pujo, Myriam, Boumendjel, Nourredine, Majbri, Nabil, Goumri, Nabila, Mingat, Nadege, Bassilios, Nader, Kerkeni, Nadia, Sedrati, Nadia, Soltani, Nadia, Maroun, Nadine, Neyrat, Nadine, Luang, Nahn, El Esper, Najeh, Ammar, Naji, Ghali, Nasredine, Hamdini, Nasser, Noel, Natacha, Potelune, Natacha, Maisonneuve, Nathalie, Pertuiset, Nathalie, Raynal, Nathalie, Vittoz, Nathalie, Terki, Nazim, Castin, Nelly, Nankeu, Nestor, Bouvier, Nicolas, Keller, Nicolas, Legros, Nicolas, Peters, Nicolas, Quirin, Nicolas, Lefrancois, Nicole, Monnier, Nicole, Rance, Nicole, Bruckmann, Niels, Mertens, Noel, Lorcy, Nolwenn, Gilbert, Olivia, Coldefy, Olivier, Drouineau, Olivier, Dunand, Olivier, Fritz, Olivier, Imhoff, Olivier, Kourilsky, Olivier, Lavelle, Olivier, Moranne, Olivier, Papin, Olivier, Roques, Olivier, Le Maner, Ophelie, Benbrahim, Oussamah Fikri, Erina Torres, Pablo Antonio, Urena Torres, Pablo Antonio, Malvezzi, Paolo, Bindi, Pascal, Cluzel, Pascal, Fontanier, Pascal, Wheatley, Pascal, Depraetre, Pascale, Dubosq, Pascale, Halin, Pascale, Sebahoun, Pascale, Siohan, Pascale, Testevuide, Pascale, Deteix, Patrice, Nolen, Patrice, Hue, Patricia, Lemarchand, Patricia, Donnadieu, Patrick, Fievet, Patrick, Fohrer, Patrick, Francais, Patrick, Giraud, Patrick, Hallonet, Patrick, Henri, Patrick, Michaut, Patrick, Niaudet, Patrick, Pauly, Patrick, Thomas, Patrick, Deleaval, Patrik, Finielz, Paul, Stroumza, Paul, Yverneau, Paule Hardy, Caillard, Pauline, Palacin, Pedro, Aubertin, Perrine, Attias, Philippe, Brunet, Philippe, Chauveau, Philippe, Coindre, Philippe, Coste, Philippe, Dubot, Philippe, Fournier, Philippe, Hiernaux, Philippe, Jousset, Philippe, Yue Wah, Philippe Lan, Lang, Philippe, Le Cacheux, Philippe, Dupont, Philippe Martin, Michel, Philippe, Mirgaine, Philippe, Moriniere, Philippe, Nicoud, Philippe, Rieu, Philippe, Rousseau, Philippe, Sporer, Philippe, Thorel, Philippe, Vanhille, Philippe, Vigeral, Philippe, Zaoui, Philippe, Bataille, Pierre, Brignon, Pierre, Filipozzi, Pierre, Housset, Pierre, Peyronnet, Pierre, Ramperez, Pierre, Vautrin, Pierre, Michel, Pierre Alexandre, Westeel, Pierre Francois, Carron, Pierre Louis, Durand, Pierre Yves, Parent, Pierrot, Seniuta, Piotr, Kuentz, François, Fraoui, Rabah, Tetaz, Rachel, Amaria, Rachid, Bourouma, Rachid, Djeffal, Rachid, Nebbad, Rachida, Allal, Radia, Dimulescu, Radu, Boustani, Rafaat, Mesbah, Rafik, Makdassi, Raifat, Diab, Raji, Puslenghea, Raluca, Roura, Raoul, Khayat, Rateb, Azar, Raymond, Frayssinet, Raymond, Monkam, Regine, Boulahrouz, Rehouni, Boudet, Remi, Demontis, Renato, Gansey, Renaud, Cuvelier, Rene, Schmitt, Renee, Noordally, Reschad, Binaut, Reynald, Latif, Rezkallah, Dufresne, Richard, Montagnac, Richard, Reade, Richard, Genin, Robert, Novo, Robert, Fickl, Rocsana, Dufresne, Roger, Magnol, Roger, Issautier, Roland, Mortelette, Romain, Delaval, Ronan, Lohro, Ronan, M'barga, Roseline, Beau, S., Dupuis, Clémentine, Vidil, Marie Jacques, Hacini, Sabria, Dahmoune, Said, Lekhal, Saliha, Sakso, Salima Ahriz, Saksi, Salima, Citarda, Salvatore, Boubenider, Samir, Kassis, Samuel, Verhille, Sandra, Genestier, Sandrine, Muller, Sandrine, Krid, Saoussen, Richter, Sarah, Delbes, Sebastien, Mailliez, Sebastien, Veillon, Sebastien, Nony, Sébastien, Benarbia, Seddick, Beaudreuil, Severine, Benyaghla, Sidi Ali, Duquennoy, Simon, Baluta, Simona, Boncila, Simona, Mzoughi, Sonia, Ribal, Sonia, Acamer, Sophie, Chauvet, Sophie, Girerd, Sophie, Ozenne, Sophie, Parahy, Sophie, Duval, Sophie Rubens, Taque, Sophie, Menouer, Soraya, Chargui, Soumaya, Bataille, Stanislas, Barbier, Stephane, Billion, Stephane, Roueff, Stephane, Torner, Stephane, Martin, Stephane Jean, Coupel, Stephanie, Cloarec, Sylvie, Lavaud, Sylvie, Leou, Sylvie, Chatelet, T., Onesta, Tania, Benhabib, Tassadit, Bensalem, Tayeb, Dimulescu, Theodora, Sawadogo, Theophile, Hitze, Thibault Dolley, Baranger, Thierry, Boudemaghe, Thierry, Hannedouche, Thierry, Krummel, Thierry, Lobbedez, Thierry, Milcent, Thierry, Dervaux, Thomas, Guincestre, Thomas, Kofman, Thomas, Raphael, Thomas, Sadreux, Thomas, Ulinski, Tim, Roger, Tiphaine Guyon, Serrato, Tomas, Kofman, Tomek, Wong, Tony, Boubia, Toufik, Gbindoun, Ubald Assogba, Khuzaie, Usama, Caudwell, Valerie, Chatelet, Valerie, Crougneau, Valerie, De Precigout, Valerie, Drouillat, Valerie, Galantine, Valerie, Hugot, Valerie Granveau, Leroy, Valerie, Boubia, Veronique, Falque, Veronique, Fournier, Veronique, Queron, Veronique, Viviani, Veronique, Gueuttin, Victor, Panescu, Victor, Calonge, Victorio Menoyo, Nguyen, Viet, Allot, Vincent, Delattre, Vincent, Leduc, Vincent, Pradier, Vincent, Aglae, Violaine Emal, Badulescu, Viorica, Molina, Virginia, Besson, Virginie, Chaigne, Virginie, Jaber, Waddah, Boudi, Wael, El Haggan, Wael, Guillon, Wen Qin, Aneni, Wided Tabbi, Hanf, William, Kohn, Wladimir, Bellenfant, Xavier, Gaudry, Xavier Moreau, Delmas, Yahsou, Knefati, Yannick, Saingra, Yannick, Tirolien, Yannick, Mann, Youssef, Brunak, Yvan, Dimitrov, Yves, Doussy, Yves, Tanter, Yves, Benabid, Zaid, Soltani, Zaara, Boukerroucha, Zacharia, Takla, Zafer, Ramanantsialonina, Zana, Dickson, Zara, Tubail, Zead, Pour, Zoe Koochaki, Boukhalfa, Zohra, Jacquot, Zohra, Couchoud, Cécile, Bayer, Florian, Ayav, Carole, Béchade, Clémence, Chantrel, François, Galland, Roula, Hourmant, Maryvonne, and Mercadal, Lucile

Published
2020
Full Text
View/download PDF

10. Air Behavior Inside Duct of Air Solar Collector with Three Models of Baffles

Author

Khaled Aliane and Mustapha Henaoui

Subjects
Materials science, 0205 materials engineering, 020502 materials, 020209 energy, 0202 electrical engineering, electronic engineering, information engineering, Duct (flow), Baffle, 02 engineering and technology, General Medicine, Mechanics
Abstract

The objective of this work is to study numerically the effect of the geometry of the baffles on the heat exchange in a solar air collector. Three models of collector were used in this study, fitted with simple baffles and perforated baffles. Fluid dynamics calculation (CFD) tool has been used to simulate the geometries of the solar collectors. Its three models involving air intake, are modeled by the FLUENT6.3 software and the grids were created with the Gambit software. The shape of the perforations is in the forms strips perforated in the baffles. The numerical resolution uses the finite volume method and the turbulence modeling K-Epsilon. The results have been validated by previous work and the simulation results are in terms of the evolution of the axial velocity and temperature distribution for the three models.

Published
2020
Full Text
View/download PDF

16. Prognostic implications of longitudinal strain in hypertensive patients

Author

Latefa Henaoui, A Meziane Tani, S. Benkhedda, and N Taleb Bendiab

Subjects
Cardiovascular event, medicine.medical_specialty, Ejection fraction, Longitudinal strain, business.industry, General Medicine, medicine.disease, Left ventricular hypertrophy, Hypertensive heart disease, Metabolic disturbance, Heart failure, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Myocardial infarction, Cardiology and Cardiovascular Medicine, business
Abstract

Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): University Hospital of Tlemcen Introduction Hypertension is a well-established risk factor for cardiovascular disease. It causes left ventricular (LV) pressure overload, and, in turn, changes in cardiac geometry and LV hypertrophy (LVH). Early impairment of LV function, detected by a reduced GLS, is associated with long-lasting, uncontrolled HBP, overweight, related metabolic changes, and is more pronounced in patients with LVH. This decline in longitudinal function may be a determining factor in the occurrence of cardiovascular complications and therefore an increase in cardiovascular morbidity and mortality. Purpose : This study sought to investigate the associations of left ventricular (LV) strain and its serial change with major adverse cardiac events in hypertensive patients. Methods We retrospectively studied 400 asymptomatic patients with hypertension of which, 182 patients had abnormal global longitudinal strain(GLS) and 218 patients had normal GLS, between 2016 and 2019. Global longitudinal strain (GLS) was measured using speckle tracking. Patients were followed for admission because of heart failure, myocardial infarction, atrial fibrillation and strokes, over median of 4 years. At the start of study, all patients had preserved LV ejection fraction. Résultats : The control of patients noted 25 cases (6.25%) of attacks of heart failure in the arm hypertension with low GLS against only 4 cases (1%) in the arm hypertension + normal GLS (P The same, 19 ( 4.75%) hypertensive patients with low GLS had a stroke compared to only 5 (1.25%) hypertensive patients with normal GLS. A significant difference in the incidence of onset of acute coronary syndromes was also noted in the hypertension arm with abnormal GLS (P = 0.002). As for rhythmic complications, 26 (6.5%) hypertensive patients with abnormal GLS developed atrial fibrillation compared to only 9 (2.25%) hypertensive patients with normal GLS (P Conclusion : GLS and its deterioration are associated with cardiovascular complications in asymptomatic hypertensive heart disease. Although LVEF will remain a cornerstone of LV function assessment, the addition of GLS enables detailed phenotyping and improved risk assessment and is a tool for present and future therapeutic advancement. A risk score incorporating strain was useful for predicting risk of cardiac events.

Published
2021
Full Text
View/download PDF

19. miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1.

Author

Christian Lacks Lino Cardenas, Imène Sarah Henaoui, Elisabeth Courcot, Christoph Roderburg, Christelle Cauffiez, Sébastien Aubert, Marie-Christine Copin, Benoit Wallaert, François Glowacki, Edmone Dewaeles, Jadranka Milosevic, Julien Maurizio, John Tedrow, Brice Marcet, Jean-Marc Lo-Guidice, Naftali Kaminski, Pascal Barbry, Tom Luedde, Michael Perrais, Bernard Mari, and Nicolas Pottier

Subjects
Genetics, QH426-470
Abstract

As miRNAs are associated with normal cellular processes, deregulation of miRNAs is thought to play a causative role in many complex diseases. Nevertheless, the precise contribution of miRNAs in fibrotic lung diseases, especially the idiopathic form (IPF), remains poorly understood. Given the poor response rate of IPF patients to current therapy, new insights into the pathogenic mechanisms controlling lung fibroblasts activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies for this devastating disease. To identify miRNAs with potential roles in lung fibrogenesis, we performed a genome-wide assessment of miRNA expression in lungs from two different mouse strains known for their distinct susceptibility to develop lung fibrosis after bleomycin exposure. This led to the identification of miR-199a-5p as the best miRNA candidate associated with bleomycin response. Importantly, miR-199a-5p pulmonary expression was also significantly increased in IPF patients (94 IPF versus 83 controls). In particular, levels of miR-199a-5p were selectively increased in myofibroblasts from injured mouse lungs and fibroblastic foci, a histologic feature associated with IPF. Therefore, miR-199a-5p profibrotic effects were further investigated in cultured lung fibroblasts: miR-199a-5p expression was induced upon TGFβ exposure, and ectopic expression of miR-199a-5p was sufficient to promote the pathogenic activation of pulmonary fibroblasts including proliferation, migration, invasion, and differentiation into myofibroblasts. In addition, we demonstrated that miR-199a-5p is a key effector of TGFβ signaling in lung fibroblasts by regulating CAV1, a critical mediator of pulmonary fibrosis. Remarkably, aberrant expression of miR-199a-5p was also found in unilateral ureteral obstruction mouse model of kidney fibrosis, as well as in both bile duct ligation and CCl4-induced mouse models of liver fibrosis, suggesting that dysregulation of miR-199a-5p represents a general mechanism contributing to the fibrotic process. MiR-199a-5p thus behaves as a major regulator of tissue fibrosis with therapeutic potency to treat fibroproliferative diseases.

Published
2013
Full Text
View/download PDF

22. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Cécile Couchoud, Florian Bayer, Carole Ayav, Clémence Béchade, Philippe Brunet, François Chantrel, Luc Frimat, Roula Galland, Maryvonne Hourmant, Emmanuelle Laurain, Thierry Lobbedez, Lucile Mercadal, Olivier Moranne, Abdelhamid Abbassi, Alain Debure, Abdallah Guerraoui, Abdelatif Benmoussa, Abdelaziz Hamani, Abdelaziz Ziane, Abdelhamid Nefti, Abdelkader Hadj, Abderrahim El Amari, Abderrahmane Ghazali, Abo Bakr Abd El Fatah Mohamed, Achour Laradi, Adel Ben Ahmed, Adel Sahar, Adele Pillet, Adeline Lacraz, Adnan Moinat, Afshin Massoumi, Agathe Pardon, Agnes Caillette Beaudoin, Agnes Chapelet Debout, Agnes Mariot, Ahmed Rachi, Aida Afiani, Aime Remy Boula, Al Jalaby, Alain Cremault, Alain Fournier, Alain Jeanson, Alain Lyon, Alain Nony, Alain Robert, Alain Slingeneyer, Alanor Agnes Labatide, Albane Brodin Sartorius, Albert Bensman, Albert Fournier, Alex Ranlin, Alex Vido Sandor, Alexandra Colombo, Alexandra Duhem, Alexandra Stancu, Alexandre Dufay, Alexandre Dumoulin, Alexandre Ebel, Alexandre Klein, Alexandre Martin, Alexandre Mouneimne, Alexandre Seidowsky, Alfio De Martin, Alfredo Zannier, Ali Aizel, Ali Hafi, Ali Zineddine Diddaoui, Alim Heyani, Alina Mocanu, Alina Preda, Aline Hafi, Aline Talaszka, Alyette Duquesne, Amar Amaouche, Amel Ghemmour, Amelie Simon, Amina Skalli, Amine Boukadida, Amr Ekhlas Ragab Eid, Ana Fedorca, Anabelle Baillet, Anais Poyet, Ancuta Bouffandeau Giorgita, Anderson Ratsimbazafy, Andre Pruna, Angel Argiles, Angelo Testa, Ann Karolien Vandooren, Anne Jolivot, Anne Kolko Labadens, Anne Lataste, Anne Maisin, Anne Paris, Anne Sechet, Anne Wuillai, Anne Elisabeth Heng, Anne Gaelle Josse, Anne Helene Querard, Anne Helene Reboux, Anne Laure Adra, Anne Laure Faller, Anne Laure Leclerc, Anne Laure Poitou, Annie Lahoche Manucci, Antoine Jacquet, Antoine Pommereau, Antoine Thierry, Arezki Adem, Arielle Chapelet, Arnaud Del Bello, Arnaud Delezire, Arnaud Garnier, Arnaud Guerard, Arnaud Klisnick, Arnaud Lionet, Arnaud Roccabianca, Arnaud Stolz, Arthur Capdeville, Asma Allal, Assem Alrifai, Assetou Diarrassouba, Assia Djema, Assia Ferhat Carre, Astrid Godron Dubrasquet, Atman Haddj Elmrabet, Audrey Jegado, Aurelia Bertholet Thomas, Aurelie Davourie Salandre, Aurelie Pajot, Aurelien Lorthioir, Aurelien Tiple, Aurore Sury, Ayman Abokasem, Ayman Sarraj, Bachir Henaoui, Baher Chaghouri, Bassem Wehbe, Beatrice Ball, Beatrice Viron, Belkassem Issad, Benedicte Hodemon Corne, Benedicte Janbon, Benjamin Deroure, Benjamin Savenkoff, Benoit Jonon, Benoit Vendrely, Benyakoub Djelaleddine, Bernard Ohry, Bernard Painchart, Bernard Strullu, Bernard Temperville, Bertin Ebikili, Bertrand Hacq, Bertrand Morel, Bilal Aoun, Blanca Muniz, Bouchra Chlih, Brahim Amara, Brice Mayor, Brigitte Gilson, Brigitte Llanas, Brigitte Zins, Bruno Bourgeon, Bruno Coevoet, Bruno Guery, Bruno Legallicier, Bruno Paris, Bruno Ranchin, Bruno Seigneuric, Camelia Ghiciuc Dita, Camelia Prelipcean, Carine Achard Hottelart, Carine Diet, Carlos Frangie, Carlos Vela, Carmina Muresan, Carole Deprele, Caroline Araujo, Caroline Bidault, Caroline Creput, Caroline Delclaux, Caroline Du Halgouet, Caroline Favennec, Caroline Freguin, Caroline Gourraud Vercel, Caroline Mesguen, Caroline Ndomo Obama, Caroline Poitou, Caroline Preissig Dirhold, Caroline Roubiou, Catherine Albert, Catherine Bessin, Catherine De Marion Gaja, Catherine Godart, Catherine Lasseur, Catherine Leocardi, Catherine Lumbroso, Catherine Melander, Catherine Michel, Catherine Quere Maurouard, Catherine Rouannet, Catherine Taddei, Cathy Verove, Cecile Guiraud, Cecile Tafelin, Cecile Turc Baron, Cedric Formet, Cedric Pinier, Celia Lessore De Ste Foy, Celine Granolleras, Chaouki Bennini, Charles Cartou, Charles Chazot, Charlotte Jouzel, Cherif Badid, Christa Roubicek, Christel Viaud, Christelle Verrier, Christian Chuet, Christian Combe, Christian Dabot, Christian Duvic, Christian Emond, Christian Lagarde, Christian Lamotte, Christian Pain, Christiane Mousson, Christie Lorriaux, Christine Beauchamp, Christine Fumeron, Christine Le Gurun, Christine Leroy, Christine Pietrement, Christine Richer, Christophe Bouaka, Christophe Charasse, Christophe Goupy, Christophe Ridel, Cindy Castrale, Cindy Detourne, Clair Francois, Claire Presne, Claire Trivin, Clarissa Von Kotze, Claude Bernard, Claude Bonniol, Claude Desvergnes, Claude Raharivelina, Claudia Nistor, Claudine Gueret, Claudine Lloret, Claudine Saltiel, Clelia Rosati, Clementine Rabate, Corina Stanescu, Corinne Ferrandini, Corinne Guibergia, Corinne Lemoine, Corinne Passeron, Cynthia Kahil, Cyril Garrouste, Cyril Vo Van, Cyrille Jolimoy, Dalila Kesraoui, Damien Jolly, Damien Thibaudin, Dan Teboulle, Daniel Daubresse, Daniel Louvet, Daniel Rasamimanantsoa, Daniel Toledano, Daniela Babici, Daniela David, Daniela Dincu, Danielle Bruno, Delia May, Delphine Haussaire, Delphine Henriet Viprey, Denis Bugnon, Denis Fouque, Denis Morin, Derradji Nour, Diab Mohamed Mahmoud, Diana Istrati Cristescu, Didier Aguilera, Didier Coste, Didier Hamel, Didier Le Chapois, Didier Testou, Dilaver Erbilgin, Djamal Dahmane, Doan Bui Quang, Dominique Bertrand, Dominique Besnier, Dominique Blanchier, Dominique Briffa, Dominique Caux, Dominique Durand, Dominique Fleury, Dominique Guerrot, Dominique Hestin, Dominique Jaubert, Dominique Joly, Dominique Lombart, Dominique Pagniez, Dominique Pierre, Dominique Schohn, Donatien Ikonga, Dorina Visanica, Dorothee Bazin, Edouard Boury, Edouard Maksour, Ekoue Agbonon, Elarbi Harrami, Elena Marcu, Elena Tudorache, Elisabeth Caniot, Elisabeth Semjen, Elisabeth Tomkiewicz, Elise Scheidt, Elke Gaboriau, Elodie Lamouroux, Elsa Guiard, Elsa Martin Passos, Emerson Nsembani, Emilie Fache, Emilie Kalbacher, Emilie Pambrun, Emilie Pincon, Emma Allain Launay, Emmanuel Baron, Emmanuel Dupuis, Emmanuel Villar, Emmanuelle Charlin, Emmanuelle Hecquet, Emmanuelle Kohler, Emmanuelle Rosier, Enrique Figueroa, Eric Azoulay, Eric Canivet, Eric Daugas, Eric Gauthier, Eric Laruelle, Eric Le Guen, Eric Legrand, Eric Moumas, Eric Postec, Eric Prinz, Eric Renaudineau, Estelle Desport, Estelle Ricard Sutra, Etienne Berard, Etienne Ged, Etienne Robin, Eve Vilaine, Evelyne Bargas, Evelyne Mac Namara, François Combarnous, Fatima Yazbeck, Fabien Gerard, Fabien Metivier, Fabien Parazols, Fabien Soulis, Fabrice Garnier, Fadhila Pech Messaoudene, Fadi Haidar, Fanny Boullenger, Fanny Lepeytre, Fanny Leroy, Fares Frejate, Farid Bellahsene, Farid Bellhasene, Farid Saidani, Fatouma Toure, Faycal Kriaa, Fazia Nemmar, Fernando Vetromile, Florence Chalmin, Florence Lucats, Florence Sens, Florence Villemain, Florent Plasse, Fouad Lebhour, Francis Schillinger, Franck Berge, Franck Bourdon, Franck Bridoux, Franck Reynaud, Francois Babinet, Francois Basse, Francois Chantrel, Francois Clair, Francois Coulomb, Francois De Cornelissen, Francois Glowacki, Francois Marchal, Francois Maurice, Francois Nobili, Francois Pourreau, Francois Provot, Francois Roux Amani, Francoise Broux, Francoise Bulte, Francoise Heibel, Francoise Leonetti, Francoise Moussion Schott, Frank Le Roy, Frederic Besson, Frederic Lavainne, Frederic Tollis, Frederique Bocquentin, Frederique Meeus, Frederique Vecina, Friederike Von Ey, Gabriel Balit, Gabriel Choukroun, Gabriel Gruget, Gabriel Huchard, Gabriella Golea, Gabrielle Duneau, Gaelle Lefrancois, Gaelle Pelle, Gaetan Lebrun, Genevieve Dumont, Georges Brillet, Georges Deschenes, Georges Mourad, Georges Stamatakis, Geraldine Cazajous, Geraldine D'ythurbide, Geraldine Robitaille Wiart, Gerard Cardon, Gerard Champion, Gerard Deschodt, Gerard Mangenot, Gerard Motte, Gerard Schortgen, Ghada Boulahia, Ghassan Maakaroun, Ghylene Bourdat Michel, Gilbert Zanetta, Gilles Hufnagel, Gilles Messier, Giorgina Piccoli, Gregoire Couvrat Desvergnes, Guillaume Bobrie, Guillaume Bonnard, Guillaume Clement, Guillaume Jean, Guillaume Queffeulou, Guillaume Seret, Guillaume Vernin, Guy Delavaud, Guy Lambrey, Guy Rostoker, Gwenaelle Poussard, Gwenaelle Roussey Kesler, H. Leon, Habib Aboubekr, Hacene Boulechfar, Hacene Sekhri, Hadia Hebibi, Hadjira Benalia, Hafed Fessi, Hafsabhai Atchia, Haiat Bittar, Hakim Maiza, Hakim Mazouz, Hamid El Ali, Hammouche Bougrida, Hans Van Der Pijl, Hassan Lokmane, Hassane Izzedine, Hassen Adda, Helene De Preneuf, Helene Leray, Helene Philippot, Henri Boulanger, Henri Merault, Henri Renaud, Herve Bonarek, Herve Maheut, Hilaire Nzeyimana, Hocine Mehama, Hocine Zaidi, Hugo Weclawiak, Hugues Flodrops, Huseyin Karaaslan, Ibrahim Haskour, Ihssen Belhadj, Imad Almoubarak, Imad Haddad, Ines Castellano, Ines Ferrandiz, Ioana Daniliuc, Ioana Darie, Ioana Enache, Ionut Prunescu, Irenee Djiconkpode, Irina Shahapuni, Isabelle Bouchoule, Isabelle Devriendt, Isabelle Kazes, Isabelle Kolb, Isabelle Landru, Isabelle Poli, Isabelle Rey, Isabelle Segalen, Isabelle Selcer, Isabelle Vernier, Isabelle Vrillon, Ismahane Guenifi, J. Dominique Gheerbrandt, Jacky Potier, Jacques Becart, Jacques Cledes, Jacques Ducros, Jacques Duvic, Jacques Fourcade, Jacques Gaultier, Jacques Jurine, Jacques Lebleu, Jacques Ollier, Jacques Ibsen Charles, Jamal Yazji, Janette Mansour, Jean Arnautou, Jean Brocard, Jean Carolfi, Jean Montoriol, Jean Baptiste Gouin, Jean Bernard Palcoux, Jean Christophe Bendini, Jean Claude Aldigier, Jean Claude Alphonse, Jean Daniel Delbet, Jean Francois Bonne, Jean Francois Cantin, Jean Francois De Fremont, Jean Francois Dessassis, Jean Francois Subra, Jean Francois Valentin, Jean Francois Verdier, Jean Jacques Dion, Jean Jacques Haultier, Jean Jacques Montseny, Jean Louis Bacri, Jean Louis Bouchet, Jean Luc Mahe, Jean Marc Chalopin, Jean Marc Gabriel, Jean Marc Hurot, Jean Marc Lanau, Jean Marie Batho, Jean Marie Coulibaly, Jean Michel Hardin, Jean Michel Marc, Jean Michel Poux, Jean Michel Rebibou, Jean Michel Tivollier, Jean Noel Ottavioli, Jean Paul Faucon, Jean Paul Imiela, Jean Paul Jaulin, Jean Paul Masselot, Jean Paul Ortiz, Jean Philippe Bourdenx, Jean Philippe Devaux, Jean Philippe Hammelin, Jean Pierre Rivory, Jean Pierre Wauquier, Jean Rene Larue, Jean Rene Mondain, Jean Sebastien Borde, Jean Simon Virot, Jean Yves Bosc, Jedjiga Achiche, Jennifer Parasote, Jeremie Diolez, Jerome Harambat, Jerome Potier, Jerome Sampol, Jihad Mustel, Jean Jacques Lefevre, Jocelyne Maurizi, Joel Gamberoni, Joelle Claudeon, Joelle Terzic, Joffrey Rogol, Johnny Sayegh, Jorge Cardozo, Jose Brasseur, Jose Guiserix, Joseph Barsumau, Julie Albaret, Julie Beaume, Julie Sohier Attias, Julien Dehay, Julien Hogan, Julien Journet, Julien Ott, Juliette Baleynaud, Justine Bacchetta, Justine Faucher, Kamel Yousfi, Karim Dardim, Karine Clabault, Karine Moreau, Kedna Thomas, Khaled Sirajedine, Khalil Chedid, Khalil El Kaeoui, Khalil El Karoui, Khedidja Bouachi, Kheira Hue, Khuzama El Nasser, Kodso Akposso, Kristian Kunz, Krzysztof Bijak, Lilia Kihal, L. Rasoloarijaona, Laid Harbouche, Larbi Bencheikh, Larbie Lamriben, Latifa Hanafi, Laura Braun Parvez, Laure Champion, Laure Croze, Laure Eprinchard, Laure Patrier, Laurence Nicolet, Laurence Vrigneaud, Laurent Duflot, Leandre Mackaya, Leila Chenine, Leon Odry, Lili Taghipour Tamiji, Lilia Antri Bouzar, Liliane Ngango Nga Messi, Lionel Le Mouellic, Lise Mandart, Lise Weis, Lise Marie Pouteau, Lora Georgieva, Lorita Vitanova, Lotfi Chalabi, Luc Delvallez, Luc Fromentin, Luc Marty, Luc Monjot, Luciana Spataru, Lucie Bessenay, Lucie Boissinot, Lucie Wajsbrot, Lucien Rakoff, Ludivine Lebourg, Lydie Perez, Lyliane Lafage, Lynda Azzouz, Madeleine Dumoulin, Messaoud Ouziala, Maan Joseph, Mabrouk Brahimi, Maeva Wong Fat, Magalie Fort, Magued Nakhla, Mahdi Abtahi, Mahen Albadawy, Mahmoud Alouach, Mahmoud Mezghani, Maite Daroux, Maklouf Boukelmoune, Malek Dhib, Malik Touam, Malina Dubau, Mamadou Balde, Man Nguyen Khoa, Manfred Ismer, Manolie Mehdi, Manon Laforet, Marc Bouiller, Marc Eugene, Marc Fila, Marc Hazzan, Marc Kribs, Marc Ladriere, Marc Lebot, Marc Padilla, Marc Souid, Marcel Marraoui, Maren Burbach, Maria Manescu, Maria Eugenia Noguera Gonzalez, Mariana Revenco, Marianne Terrasse, Marie Essi, Marie Alice Macher, Marie Beatrice Nogier, Marie Cecile Cazin, Marie Christine Schweitzer Camoin, Marie Christine Thouret, Marie Claude Hannaert, Marie France Servel, Marie Helene Chabannier, Marie Jeanne Coudert Krier, Marie Noelle Catoliquot, Marie Paule Guillodo, Marie Sophie Gavard, Marie Xaviere Vairon Codaccioni, Marina Rabec, Marine Freist, Marion Gauthier, Marion Lemaire, Marion Mehrenberger, Marion Venot, Marios Pongas, Marlene Beaubrun Diant, Martial Levannier, Martine Bertaux, Mathieu Jablonski, Mathieu Sacquepee, Mathilde Dargelos, Mathilde Lemoine, Mathilde Tamain, Matthieu Monge, Matthieu Reberolle, Maud Cousin, Maud Francois, Maurice Baron, Maxime Hoffmann, Maxime Ingwiller, Maxime Touzot, Mederick Mohajer, Mehadji Maaz, Melanie Hanoy, Melanie Marroc, Melodie Cuny, Menno Van Der Straaten, Mf. Serveaux, Michel Basteri, Michel Fen Chong, Michel Hecht, Michel Massad, Michel Normand, Michel Olmer, Michel Tolani, Michel Tsimaratos, Michele Hemery, Michele Kessler, Miguel Esposito, Milad Shenouda, Mimi Kareche, Mina Khalili, Mirella Diaconita, Mohamad Khair Rifard, Mohamed Aladib, Mohamed Belmouaz, Mohamed Brahim, Mohamed Diouani, Mohamed Fodil Cherif, Mohamed Jamali, Mohamed Maghlaoua, Mohamed Meddeb, Mohamed Ramdane, Mohamed Rifaat, Mohamed Sharifull Islam, Mohamed Adnan Abbade, Mokhtar Amrandi, Mokhtar Chawki, Monica Ciobotaru, Monica Indrieis, Monique Chanas, Monique Hoarau, Monzer Tomeh, Moufida Bellou, Mouloud Bouzernidj, Mounia Ammor, Mounir Guergour, Mountassir Benzakour, Mourad Hachicha, Moussa Coulibaly, Mustafa Smati, Mustapha Al Morabiti, Mustapha Amirou, Myriam Isnard, Myriam Pastural, Myriam Pujo, Nourredine Boumendjel, Nabil Majbri, Nabila Goumri, Nadege Mingat, Nader Bassilios, Nadia Kerkeni, Nadia Sedrati, Nadia Soltani, Nadine Maroun, Nadine Neyrat, Nahn Luang, Najeh El Esper, Naji Ammar, Nasredine Ghali, Nasser Hamdini, Natacha Noel, Natacha Potelune, Nathalie Maisonneuve, Nathalie Pertuiset, Nathalie Raynal, Nathalie Vittoz, Nazim Terki, Nelly Castin, Nestor Nankeu, Nicolas Bouvier, Nicolas Keller, Nicolas Legros, Nicolas Peters, Nicolas Quirin, Nicole Lefrancois, Nicole Monnier, Nicole Rance, Niels Bruckmann, Noel Mertens, Nolwenn Lorcy, Olivia Gilbert, Olivier Coldefy, Olivier Drouineau, Olivier Dunand, Olivier Fritz, Olivier Imhoff, Olivier Kourilsky, Olivier Lavelle, Olivier Papin, Olivier Roques, Ophelie Le Maner, Oussamah Fikri Benbrahim, Pablo Antonio Erina Torres, Pablo Antonio Urena Torres, Paolo Malvezzi, Pascal Bindi, Pascal Cluzel, Pascal Fontanier, Pascal Wheatley, Pascale Depraetre, Pascale Dubosq, Pascale Halin, Pascale Sebahoun, Pascale Siohan, Pascale Testevuide, Patrice Deteix, Patrice Nolen, Patricia Hue, Patricia Lemarchand, Patrick Donnadieu, Patrick Fievet, Patrick Fohrer, Patrick Francais, Patrick Giraud, Patrick Hallonet, Patrick Henri, Patrick Michaut, Patrick Niaudet, Patrick Pauly, Patrick Thomas, Patrik Deleaval, Paul Finielz, Paul Stroumza, Paule Hardy Yverneau, Pauline Caillard, Pedro Palacin, Perrine Aubertin, Philippe Attias, Philippe Chauveau, Philippe Coindre, Philippe Coste, Philippe Dubot, Philippe Fournier, Philippe Hiernaux, Philippe Jousset, Philippe Lan Yue Wah, Philippe Lang, Philippe Le Cacheux, Philippe Martin Dupont, Philippe Michel, Philippe Mirgaine, Philippe Moriniere, Philippe Nicoud, Philippe Rieu, Philippe Rousseau, Philippe Sporer, Philippe Thorel, Philippe Vanhille, Philippe Vigeral, Philippe Zaoui, Pierre Bataille, Pierre Brignon, Pierre Filipozzi, Pierre Housset, Pierre Peyronnet, Pierre Ramperez, Pierre Vautrin, Pierre Alexandre Michel, Pierre Francois Westeel, Pierre Louis Carron, Pierre Yves Durand, Pierrot Parent, Piotr Seniuta, François Kuentz, Rabah Fraoui, Rachel Tetaz, Rachid Amaria, Rachid Bourouma, Rachid Djeffal, Rachida Nebbad, Radia Allal, Radu Dimulescu, Rafaat Boustani, Rafik Mesbah, Raifat Makdassi, Raji Diab, Raluca Puslenghea, Raoul Roura, Rateb Khayat, Raymond Azar, Raymond Frayssinet, Regine Monkam, Rehouni Boulahrouz, Remi Boudet, Renato Demontis, Renaud Gansey, Rene Cuvelier, Renee Schmitt, Reschad Noordally, Reynald Binaut, Rezkallah Latif, Richard Dufresne, Richard Montagnac, Richard Reade, Robert Genin, Robert Novo, Rocsana Fickl, Roger Dufresne, Roger Magnol, Roland Issautier, Romain Mortelette, Ronan Delaval, Ronan Lohro, Roseline M'barga, S. Beau, Clémentine Dupuis, Marie Jacques Vidil, Sabria Hacini, Said Dahmoune, Saliha Lekhal, Salima Ahriz Sakso, Salima Saksi, Salvatore Citarda, Samir Boubenider, Samuel Kassis, Sandra Verhille, Sandrine Genestier, Sandrine Muller, Saoussen Krid, Sarah Richter, Sebastien Delbes, Sebastien Mailliez, Sebastien Veillon, Sébastien Nony, Seddick Benarbia, Severine Beaudreuil, Sidi Ali Benyaghla, Simon Duquennoy, Simona Baluta, Simona Boncila, Sonia Mzoughi, Sonia Ribal, Sophie Acamer, Sophie Chauvet, Sophie Girerd, Sophie Ozenne, Sophie Parahy, Sophie Rubens Duval, Sophie Taque, Soraya Menouer, Soumaya Chargui, Stanislas Bataille, Stephane Barbier, Stephane Billion, Stephane Roueff, Stephane Torner, Stephane Jean Martin, Stephanie Coupel, Sylvie Cloarec, Sylvie Lavaud, Sylvie Leou, T. Chatelet, Tania Onesta, Tassadit Benhabib, Tayeb Bensalem, Theodora Dimulescu, Theophile Sawadogo, Thibault Dolley Hitze, Thierry Baranger, Thierry Boudemaghe, Thierry Hannedouche, Thierry Krummel, Thierry Milcent, Thomas Dervaux, Thomas Guincestre, Thomas Kofman, Thomas Raphael, Thomas Sadreux, Tim Ulinski, Tiphaine Guyon Roger, Tomas Serrato, Tomek Kofman, Tony Wong, Toufik Boubia, Ubald Assogba Gbindoun, Usama Khuzaie, Valerie Caudwell, Valerie Chatelet, Valerie Crougneau, Valerie De Precigout, Valerie Drouillat, Valerie Galantine, Valerie Granveau Hugot, Valerie Leroy, Veronique Boubia, Veronique Falque, Veronique Fournier, Veronique Queron, Veronique Viviani, Victor Gueuttin, Victor Panescu, Victorio Menoyo Calonge, Viet Nguyen, Vincent Allot, Vincent Delattre, Vincent Leduc, Vincent Pradier, Violaine Emal Aglae, Viorica Badulescu, Virginia Molina, Virginie Besson, Virginie Chaigne, Waddah Jaber, Wael Boudi, Wael El Haggan, Wen Qin Guillon, Wided Tabbi Aneni, William Hanf, Wladimir Kohn, Xavier Bellenfant, Xavier Moreau Gaudry, Yahsou Delmas, Yannick Knefati, Yannick Saingra, Yannick Tirolien, Youssef Mann, Yvan Brunak, Yves Dimitrov, Yves Doussy, Yves Tanter, Zaid Benabid, Zaara Soltani, Zacharia Boukerroucha, Zafer Takla, Zana Ramanantsialonina, Zara Dickson, Zead Tubail, Zoe Koochaki Pour, Zohra Boukhalfa, Zohra Jacquot, Agence de la biomédecine [Saint-Denis la Plaine], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Caen Normandie (UNICAEN), Normandie Université (NU), CALYDIAL Vienne, Partenaires INRAE, Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Armand Trousseau [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), Centre Universitaire des Maladies Rénales [CHU Caen] (CUMR Caen), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Groupe hospitalier de la région de Mulhouse Sud-Alsace (GHRMSA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Assistance Publique - Hôpitaux de Marseille (APHM), Service de diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Service de Diabétologie [CHU Pitié-Salpétrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Male, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Hemodialysis, Home, Disease, MESH: COVID-19 / therapy, registry, Ambulatory Care Facilities, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Aged, 80 and over, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Risk Factors, 80 and over, Prevalence, covid, dialysis, epidemiology, mortality, Aged, Aged, 80 and over, COVID-19, Case-Control Studies, Critical Care, Female, France, Humans, Incidence, Middle Aged, Patient Acuity, Protective Factors, Registries, Renal Dialysis, SARS-CoV-2, Sex Factors, Hypoalbuminemia, MESH: France / epidemiology, education.field_of_study, Incidence (epidemiology), 3. Good health, MESH: COVID-19 / epidemiology, Nephrology, Hemodialysis, medicine.medical_specialty, Population, Lower risk, Article, 03 medical and health sciences, MESH: Sex Factors, Internal medicine, medicine, MESH: SARS-CoV-2, MESH: Renal Dialysis / statistics & numerical data, education, Dialysis, Vascular disease, business.industry, medicine.disease, Former Smoker, MESH: Critical Care / statistics & numerical data, 030104 developmental biology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Home, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH: Hemodialysis, Home / statistics & numerical data
Abstract

The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed., Graphical abstract

Published
2020
Full Text
View/download PDF

23. The Impact of Uncontrolled Hypertension on the Longitudinal Systolic Function of the Left Ventricle

Author

Latifa Henaoui, S. Benkhedda, Nabila Soufi Taleb Bendiab, and Abderrahim Meziane Tani

Subjects
medicine.medical_specialty, Longitudinal strain, Heart Ventricles, Early detection, Systolic function, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, Ventricular Dysfunction, Left, 0302 clinical medicine, Diastole, Internal medicine, Systolic strain, Internal Medicine, medicine, Humans, 030212 general & internal medicine, business.industry, Ultrasound, Stroke Volume, Blood pressure, medicine.anatomical_structure, Ventricle, Echocardiography, Hypertension, Cardiology, Early diastolic, business
Abstract

Background: The assessment of the longitudinal component of left ventricular (LV) function is of major clinical importance for the early detection of LV contractile impairment. The aim of this study was to determine the impact of uncontrolled hypertension, on LV longitudinal systolic performance. Methods: The study population included 400 hypertensive patients: 271 patients with uncontrolled blood pressure (BP) and 112 without controlled BP, all patients underwent a complete ultrasound evaluation with the calculation of the LV mass, evaluation of diastolic function as well as longitudinal systolic function. Results: Conventional echo demonstrated that uncontrolled patients had increased LV mass (P 0.007), LA (left auricular) dimension (P 0.004), left ventricular wall thickness and impairment of diastolic function (E/E’6 ± 2.1 vs 7.4 ±3.0 P=0.001) while no affection of systolic function could be detected. By deformation imaging, there was a reduction in longitudinal strain (apical 4 view -16.2 ±2.9 vs -18.2± 2.6 P 0.02, apical 3 view -17.3 ± 3.3 vs. -18.9 ± 4.1 P 0.01). Similarly, systolic strain rate (SRsys) and early diastolic SR (SRe) reduced significantly in longitudinal direction. Conclusion: Although EF was not different between uncontrolled patients and controls, LV longitudinal strain and strain rate by 2D speckle tracking were lower in the uncontrolled group.

Published
2020

24. Évaluation du délai DIDO (door in-door out) des syndromes coronariens aigus dans les hôpitaux sans cardiologie interventionnelle du réseau RESSIF

Author

Lionel Lamhaut, T. H. Ta, F.-X. Laborne, C. Cahuzac, A. Henaoui, M. Porche, D. Sapir, N. Briole, and H. Andrianjafy

Subjects
Emergency Medicine
Abstract

Objectifs : Le délai door in-door out (DIDO) représente la durée de séjour au service d’urgence (SU) des patients pris en charge pour un syndrome coronarien aigu ST+ (SCAST+), avant transfert en centre de cardiologie interventionnelle (CCI). Le DIDO ne devrait pas dépasser 30 minutes. Notre objectif était d’évaluer le DIDO dans le réseau des urgences Sud Île-de-France (RESSIF). Matériel et méthodes : Étude épidémiologique, rétrospective, multicentrique comparant le DIDO entre 2014 et 2015 (période 1), puis en 2016 (période 2) dans deux hôpitaux sans CCI, l’hôpital de Longjumeau et l’hôpital d’Arpajon. En 2016 était appliqué dans notre protocole régional SCAST+ le « réflexe électro-oculotéléphonique » (REOT), avec l’objectif de diminuer le DIDO : dès l’électrocardiogramme qualifiant (ECGq), avant tout traitement ou obtention du CCI de transfert, le médecin urgentiste appelle le service d’aide médicale à l’urgence (SAMU) pour l’envoi immédiat d’un service mobile d’urgence et de réanimation (SMUR) secondaire. Résultats : Entre les deux périodes, le délai DIDO médian n’a pas été modifié significativement (–16 min [4–42] ; p = 0,06). Le délai entre ECGq et appel du SAMU n’était pas significativement différent avant et après application du REOT (15 [8–34] vs 9 min [6–26] ; p = 0,12). Le DIDO était supérieur ou égal à 30 min en période 1, contre 6 % en période 2 (p = 0,11). Conclusion : Le DIDO du RESSIF n’a pas été significativement modifié. Il n’y a pas eu d’impact significatif du REOT sur le DIDO, mais notre étude manque de puissance. Le REOT pourrait être évalué plus largement dans les SU. Un réseau de soins impliquant les SAMU, SMUR, SU et CCI avec protocoles partagés est essentiel pour le pronostic des SCAST+.

Published
2018
Full Text
View/download PDF

25. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Couchoud, Cécile, primary, Bayer, Florian, additional, Ayav, Carole, additional, Béchade, Clémence, additional, Brunet, Philippe, additional, Chantrel, François, additional, Frimat, Luc, additional, Galland, Roula, additional, Hourmant, Maryvonne, additional, Laurain, Emmanuelle, additional, Lobbedez, Thierry, additional, Mercadal, Lucile, additional, Moranne, Olivier, additional, Abbassi, Abdelhamid, additional, Debure, Alain, additional, Guerraoui, Abdallah, additional, Benmoussa, Abdelatif, additional, Hamani, Abdelaziz, additional, Ziane, Abdelaziz, additional, Nefti, Abdelhamid, additional, Hadj, Abdelkader, additional, El Amari, Abderrahim, additional, Ghazali, Abderrahmane, additional, Abd El Fatah Mohamed, Abo Bakr, additional, Laradi, Achour, additional, Ben Ahmed, Adel, additional, Sahar, Adel, additional, Pillet, Adele, additional, Lacraz, Adeline, additional, Moinat, Adnan, additional, Massoumi, Afshin, additional, Pardon, Agathe, additional, Beaudoin, Agnes Caillette, additional, Debout, Agnes Chapelet, additional, Mariot, Agnes, additional, Rachi, Ahmed, additional, Afiani, Aida, additional, Boula, Aime Remy, additional, Jalaby, Al, additional, Cremault, Alain, additional, Fournier, Alain, additional, Jeanson, Alain, additional, Lyon, Alain, additional, Nony, Alain, additional, Robert, Alain, additional, Slingeneyer, Alain, additional, Labatide, Alanor Agnes, additional, Sartorius, Albane Brodin, additional, Bensman, Albert, additional, Fournier, Albert, additional, Ranlin, Alex, additional, Sandor, Alex Vido, additional, Colombo, Alexandra, additional, Duhem, Alexandra, additional, Stancu, Alexandra, additional, Dufay, Alexandre, additional, Dumoulin, Alexandre, additional, Ebel, Alexandre, additional, Klein, Alexandre, additional, Martin, Alexandre, additional, Mouneimne, Alexandre, additional, Seidowsky, Alexandre, additional, De Martin, Alfio, additional, Zannier, Alfredo, additional, Aizel, Ali, additional, Hafi, Ali, additional, Diddaoui, Ali Zineddine, additional, Heyani, Alim, additional, Mocanu, Alina, additional, Preda, Alina, additional, Hafi, Aline, additional, Talaszka, Aline, additional, Duquesne, Alyette, additional, Amaouche, Amar, additional, Ghemmour, Amel, additional, Simon, Amelie, additional, Skalli, Amina, additional, Boukadida, Amine, additional, Ragab Eid, Amr Ekhlas, additional, Fedorca, Ana, additional, Baillet, Anabelle, additional, Poyet, Anais, additional, Giorgita, Ancuta Bouffandeau, additional, Ratsimbazafy, Anderson, additional, Pruna, Andre, additional, Argiles, Angel, additional, Testa, Angelo, additional, Vandooren, Ann Karolien, additional, Jolivot, Anne, additional, Labadens, Anne Kolko, additional, Lataste, Anne, additional, Maisin, Anne, additional, Paris, Anne, additional, Sechet, Anne, additional, Wuillai, Anne, additional, Heng, Anne Elisabeth, additional, Josse, Anne Gaelle, additional, Querard, Anne Helene, additional, Reboux, Anne Helene, additional, Adra, Anne Laure, additional, Faller, Anne Laure, additional, Leclerc, Anne Laure, additional, Poitou, Anne Laure, additional, Manucci, Annie Lahoche, additional, Jacquet, Antoine, additional, Pommereau, Antoine, additional, Thierry, Antoine, additional, Adem, Arezki, additional, Chapelet, Arielle, additional, Del Bello, Arnaud, additional, Delezire, Arnaud, additional, Garnier, Arnaud, additional, Guerard, Arnaud, additional, Klisnick, Arnaud, additional, Lionet, Arnaud, additional, Roccabianca, Arnaud, additional, Stolz, Arnaud, additional, Capdeville, Arthur, additional, Allal, Asma, additional, Alrifai, Assem, additional, Diarrassouba, Assetou, additional, Djema, Assia, additional, Carre, Assia Ferhat, additional, Dubrasquet, Astrid Godron, additional, Elmrabet, Atman Haddj, additional, Jegado, Audrey, additional, Thomas, Aurelia Bertholet, additional, Salandre, Aurelie Davourie, additional, Pajot, Aurelie, additional, Lorthioir, Aurelien, additional, Tiple, Aurelien, additional, Sury, Aurore, additional, Abokasem, Ayman, additional, Sarraj, Ayman, additional, Henaoui, Bachir, additional, Chaghouri, Baher, additional, Wehbe, Bassem, additional, Ball, Beatrice, additional, Viron, Beatrice, additional, Issad, Belkassem, additional, Corne, Benedicte Hodemon, additional, Janbon, Benedicte, additional, Deroure, Benjamin, additional, Savenkoff, Benjamin, additional, Jonon, Benoit, additional, Vendrely, Benoit, additional, Djelaleddine, Benyakoub, additional, Ohry, Bernard, additional, Painchart, Bernard, additional, Strullu, Bernard, additional, Temperville, Bernard, additional, Ebikili, Bertin, additional, Hacq, Bertrand, additional, Morel, Bertrand, additional, Aoun, Bilal, additional, Muniz, Blanca, additional, Chlih, Bouchra, additional, Amara, Brahim, additional, Mayor, Brice, additional, Gilson, Brigitte, additional, Llanas, Brigitte, additional, Zins, Brigitte, additional, Bourgeon, Bruno, additional, Coevoet, Bruno, additional, Guery, Bruno, additional, Legallicier, Bruno, additional, Paris, Bruno, additional, Ranchin, Bruno, additional, Seigneuric, Bruno, additional, Dita, Camelia Ghiciuc, additional, Prelipcean, Camelia, additional, Hottelart, Carine Achard, additional, Diet, Carine, additional, Frangie, Carlos, additional, Vela, Carlos, additional, Muresan, Carmina, additional, Deprele, Carole, additional, Araujo, Caroline, additional, Bidault, Caroline, additional, Creput, Caroline, additional, Delclaux, Caroline, additional, Du Halgouet, Caroline, additional, Favennec, Caroline, additional, Freguin, Caroline, additional, Vercel, Caroline Gourraud, additional, Mesguen, Caroline, additional, Obama, Caroline Ndomo, additional, Poitou, Caroline, additional, Dirhold, Caroline Preissig, additional, Roubiou, Caroline, additional, Albert, Catherine, additional, Bessin, Catherine, additional, De Marion Gaja, Catherine, additional, Godart, Catherine, additional, Lasseur, Catherine, additional, Leocardi, Catherine, additional, Lumbroso, Catherine, additional, Melander, Catherine, additional, Michel, Catherine, additional, Maurouard, Catherine Quere, additional, Rouannet, Catherine, additional, Taddei, Catherine, additional, Verove, Cathy, additional, Guiraud, Cecile, additional, Tafelin, Cecile, additional, Baron, Cecile Turc, additional, Formet, Cedric, additional, Pinier, Cedric, additional, De Ste Foy, Celia Lessore, additional, Granolleras, Celine, additional, Bennini, Chaouki, additional, Cartou, Charles, additional, Chazot, Charles, additional, Jouzel, Charlotte, additional, Badid, Cherif, additional, Roubicek, Christa, additional, Viaud, Christel, additional, Verrier, Christelle, additional, Chuet, Christian, additional, Combe, Christian, additional, Dabot, Christian, additional, Duvic, Christian, additional, Emond, Christian, additional, Lagarde, Christian, additional, Lamotte, Christian, additional, Pain, Christian, additional, Mousson, Christiane, additional, Lorriaux, Christie, additional, Beauchamp, Christine, additional, Fumeron, Christine, additional, Le Gurun, Christine, additional, Leroy, Christine, additional, Pietrement, Christine, additional, Richer, Christine, additional, Bouaka, Christophe, additional, Charasse, Christophe, additional, Goupy, Christophe, additional, Ridel, Christophe, additional, Castrale, Cindy, additional, Detourne, Cindy, additional, Francois, Clair, additional, Presne, Claire, additional, Trivin, Claire, additional, Von Kotze, Clarissa, additional, Bernard, Claude, additional, Bonniol, Claude, additional, Desvergnes, Claude, additional, Raharivelina, Claude, additional, Nistor, Claudia, additional, Gueret, Claudine, additional, Lloret, Claudine, additional, Saltiel, Claudine, additional, Rosati, Clelia, additional, Rabate, Clementine, additional, Stanescu, Corina, additional, Ferrandini, Corinne, additional, Guibergia, Corinne, additional, Lemoine, Corinne, additional, Passeron, Corinne, additional, Kahil, Cynthia, additional, Garrouste, Cyril, additional, Van, Cyril Vo, additional, Jolimoy, Cyrille, additional, Kesraoui, Dalila, additional, Jolly, Damien, additional, Thibaudin, Damien, additional, Teboulle, Dan, additional, Daubresse, Daniel, additional, Louvet, Daniel, additional, Rasamimanantsoa, Daniel, additional, Toledano, Daniel, additional, Babici, Daniela, additional, David, Daniela, additional, Dincu, Daniela, additional, Bruno, Danielle, additional, May, Delia, additional, Haussaire, Delphine, additional, Viprey, Delphine Henriet, additional, Bugnon, Denis, additional, Fouque, Denis, additional, Morin, Denis, additional, Nour, Derradji, additional, Mahmoud, Diab Mohamed, additional, Cristescu, Diana Istrati, additional, Aguilera, Didier, additional, Coste, Didier, additional, Hamel, Didier, additional, Le Chapois, Didier, additional, Testou, Didier, additional, Erbilgin, Dilaver, additional, Dahmane, Djamal, additional, Quang, Doan Bui, additional, Bertrand, Dominique, additional, Besnier, Dominique, additional, Blanchier, Dominique, additional, Briffa, Dominique, additional, Caux, Dominique, additional, Durand, Dominique, additional, Fleury, Dominique, additional, Guerrot, Dominique, additional, Hestin, Dominique, additional, Jaubert, Dominique, additional, Joly, Dominique, additional, Lombart, Dominique, additional, Pagniez, Dominique, additional, Pierre, Dominique, additional, Schohn, Dominique, additional, Ikonga, Donatien, additional, Visanica, Dorina, additional, Bazin, Dorothee, additional, Boury, Edouard, additional, Maksour, Edouard, additional, Agbonon, Ekoue, additional, Harrami, Elarbi, additional, Marcu, Elena, additional, Tudorache, Elena, additional, Caniot, Elisabeth, additional, Semjen, Elisabeth, additional, Tomkiewicz, Elisabeth, additional, Scheidt, Elise, additional, Gaboriau, Elke, additional, Lamouroux, Elodie, additional, Guiard, Elsa, additional, Passos, Elsa Martin, additional, Nsembani, Emerson, additional, Fache, Emilie, additional, Kalbacher, Emilie, additional, Pambrun, Emilie, additional, Pincon, Emilie, additional, Launay, Emma Allain, additional, Baron, Emmanuel, additional, Dupuis, Emmanuel, additional, Villar, Emmanuel, additional, Charlin, Emmanuelle, additional, Hecquet, Emmanuelle, additional, Kohler, Emmanuelle, additional, Rosier, Emmanuelle, additional, Figueroa, Enrique, additional, Azoulay, Eric, additional, Canivet, Eric, additional, Daugas, Eric, additional, Gauthier, Eric, additional, Laruelle, Eric, additional, Le Guen, Eric, additional, Legrand, Eric, additional, Moumas, Eric, additional, Postec, Eric, additional, Prinz, Eric, additional, Renaudineau, Eric, additional, Desport, Estelle, additional, Sutra, Estelle Ricard, additional, Berard, Etienne, additional, Ged, Etienne, additional, Robin, Etienne, additional, Vilaine, Eve, additional, Bargas, Evelyne, additional, Namara, Evelyne Mac, additional, Combarnous, François, additional, Yazbeck, Fatima, additional, Gerard, Fabien, additional, Metivier, Fabien, additional, Parazols, Fabien, additional, Soulis, Fabien, additional, Garnier, Fabrice, additional, Messaoudene, Fadhila Pech, additional, Haidar, Fadi, additional, Boullenger, Fanny, additional, Lepeytre, Fanny, additional, Leroy, Fanny, additional, Frejate, Fares, additional, Bellahsene, Farid, additional, Bellhasene, Farid, additional, Saidani, Farid, additional, Toure, Fatouma, additional, Kriaa, Faycal, additional, Nemmar, Fazia, additional, Vetromile, Fernando, additional, Chalmin, Florence, additional, Lucats, Florence, additional, Sens, Florence, additional, Villemain, Florence, additional, Plasse, Florent, additional, Lebhour, Fouad, additional, Schillinger, Francis, additional, Berge, Franck, additional, Bourdon, Franck, additional, Bridoux, Franck, additional, Reynaud, Franck, additional, Babinet, Francois, additional, Basse, Francois, additional, Chantrel, Francois, additional, Clair, Francois, additional, Coulomb, Francois, additional, De Cornelissen, Francois, additional, Glowacki, Francois, additional, Marchal, Francois, additional, Maurice, Francois, additional, Nobili, Francois, additional, Pourreau, Francois, additional, Provot, Francois, additional, Amani, Francois Roux, additional, Broux, Francoise, additional, Bulte, Francoise, additional, Heibel, Francoise, additional, Leonetti, Francoise, additional, Schott, Francoise Moussion, additional, Le Roy, Frank, additional, Besson, Frederic, additional, Lavainne, Frederic, additional, Tollis, Frederic, additional, Bocquentin, Frederique, additional, Meeus, Frederique, additional, Vecina, Frederique, additional, Von Ey, Friederike, additional, Balit, Gabriel, additional, Choukroun, Gabriel, additional, Gruget, Gabriel, additional, Huchard, Gabriel, additional, Golea, Gabriella, additional, Duneau, Gabrielle, additional, Lefrancois, Gaelle, additional, Pelle, Gaelle, additional, Lebrun, Gaetan, additional, Dumont, Genevieve, additional, Brillet, Georges, additional, Deschenes, Georges, additional, Mourad, Georges, additional, Stamatakis, Georges, additional, Cazajous, Geraldine, additional, D'ythurbide, Geraldine, additional, Wiart, Geraldine Robitaille, additional, Cardon, Gerard, additional, Champion, Gerard, additional, Deschodt, Gerard, additional, Mangenot, Gerard, additional, Motte, Gerard, additional, Schortgen, Gerard, additional, Boulahia, Ghada, additional, Maakaroun, Ghassan, additional, Michel, Ghylene Bourdat, additional, Zanetta, Gilbert, additional, Hufnagel, Gilles, additional, Messier, Gilles, additional, Piccoli, Giorgina, additional, Desvergnes, Gregoire Couvrat, additional, Bobrie, Guillaume, additional, Bonnard, Guillaume, additional, Clement, Guillaume, additional, Jean, Guillaume, additional, Queffeulou, Guillaume, additional, Seret, Guillaume, additional, Vernin, Guillaume, additional, Delavaud, Guy, additional, Lambrey, Guy, additional, Rostoker, Guy, additional, Poussard, Gwenaelle, additional, Kesler, Gwenaelle Roussey, additional, Leon, H., additional, Aboubekr, Habib, additional, Boulechfar, Hacene, additional, Sekhri, Hacene, additional, Hebibi, Hadia, additional, Benalia, Hadjira, additional, Fessi, Hafed, additional, Atchia, Hafsabhai, additional, Bittar, Haiat, additional, Maiza, Hakim, additional, Mazouz, Hakim, additional, El Ali, Hamid, additional, Bougrida, Hammouche, additional, Van Der Pijl, Hans, additional, Lokmane, Hassan, additional, Izzedine, Hassane, additional, Adda, Hassen, additional, De Preneuf, Helene, additional, Leray, Helene, additional, Philippot, Helene, additional, Boulanger, Henri, additional, Merault, Henri, additional, Renaud, Henri, additional, Bonarek, Herve, additional, Maheut, Herve, additional, Nzeyimana, Hilaire, additional, Mehama, Hocine, additional, Zaidi, Hocine, additional, Weclawiak, Hugo, additional, Flodrops, Hugues, additional, Karaaslan, Huseyin, additional, Haskour, Ibrahim, additional, Belhadj, Ihssen, additional, Almoubarak, Imad, additional, Haddad, Imad, additional, Castellano, Ines, additional, Ferrandiz, Ines, additional, Daniliuc, Ioana, additional, Darie, Ioana, additional, Enache, Ioana, additional, Prunescu, Ionut, additional, Djiconkpode, Irenee, additional, Shahapuni, Irina, additional, Bouchoule, Isabelle, additional, Devriendt, Isabelle, additional, Kazes, Isabelle, additional, Kolb, Isabelle, additional, Landru, Isabelle, additional, Poli, Isabelle, additional, Rey, Isabelle, additional, Segalen, Isabelle, additional, Selcer, Isabelle, additional, Vernier, Isabelle, additional, Vrillon, Isabelle, additional, Guenifi, Ismahane, additional, Gheerbrandt, J. Dominique, additional, Potier, Jacky, additional, Becart, Jacques, additional, Cledes, Jacques, additional, Ducros, Jacques, additional, Duvic, Jacques, additional, Fourcade, Jacques, additional, Gaultier, Jacques, additional, Jurine, Jacques, additional, Lebleu, Jacques, additional, Ollier, Jacques, additional, Charles, Jacques Ibsen, additional, Yazji, Jamal, additional, Mansour, Janette, additional, Arnautou, Jean, additional, Brocard, Jean, additional, Carolfi, Jean, additional, Montoriol, Jean, additional, Gouin, Jean Baptiste, additional, Palcoux, Jean Bernard, additional, Bendini, Jean Christophe, additional, Aldigier, Jean Claude, additional, Alphonse, Jean Claude, additional, Delbet, Jean Daniel, additional, Bonne, Jean Francois, additional, Cantin, Jean Francois, additional, De Fremont, Jean Francois, additional, Dessassis, Jean Francois, additional, Subra, Jean Francois, additional, Valentin, Jean Francois, additional, Verdier, Jean Francois, additional, Dion, Jean Jacques, additional, Haultier, Jean Jacques, additional, Montseny, Jean Jacques, additional, Bacri, Jean Louis, additional, Bouchet, Jean Louis, additional, Mahe, Jean Luc, additional, Chalopin, Jean Marc, additional, Gabriel, Jean Marc, additional, Hurot, Jean Marc, additional, Lanau, Jean Marc, additional, Batho, Jean Marie, additional, Coulibaly, Jean Marie, additional, Hardin, Jean Michel, additional, Marc, Jean Michel, additional, Poux, Jean Michel, additional, Rebibou, Jean Michel, additional, Tivollier, Jean Michel, additional, Ottavioli, Jean Noel, additional, Faucon, Jean Paul, additional, Imiela, Jean Paul, additional, Jaulin, Jean Paul, additional, Masselot, Jean Paul, additional, Ortiz, Jean Paul, additional, Bourdenx, Jean Philippe, additional, Devaux, Jean Philippe, additional, Hammelin, Jean Philippe, additional, Rivory, Jean Pierre, additional, Wauquier, Jean Pierre, additional, Larue, Jean Rene, additional, Mondain, Jean Rene, additional, Borde, Jean Sebastien, additional, Virot, Jean Simon, additional, Bosc, Jean Yves, additional, Achiche, Jedjiga, additional, Parasote, Jennifer, additional, Diolez, Jeremie, additional, Harambat, Jerome, additional, Potier, Jerome, additional, Sampol, Jerome, additional, Mustel, Jihad, additional, Lefevre, Jean Jacques, additional, Maurizi, Jocelyne, additional, Gamberoni, Joel, additional, Claudeon, Joelle, additional, Terzic, Joelle, additional, Rogol, Joffrey, additional, Sayegh, Johnny, additional, Cardozo, Jorge, additional, Brasseur, Jose, additional, Guiserix, Jose, additional, Barsumau, Joseph, additional, Albaret, Julie, additional, Beaume, Julie, additional, Attias, Julie Sohier, additional, Dehay, Julien, additional, Hogan, Julien, additional, Journet, Julien, additional, Ott, Julien, additional, Baleynaud, Juliette, additional, Bacchetta, Justine, additional, Faucher, Justine, additional, Yousfi, Kamel, additional, Dardim, Karim, additional, Clabault, Karine, additional, Moreau, Karine, additional, Thomas, Kedna, additional, Sirajedine, Khaled, additional, Chedid, Khalil, additional, El Kaeoui, Khalil, additional, El Karoui, Khalil, additional, Bouachi, Khedidja, additional, Hue, Kheira, additional, El Nasser, Khuzama, additional, Akposso, Kodso, additional, Kunz, Kristian, additional, Bijak, Krzysztof, additional, Kihal, Lilia, additional, Rasoloarijaona, L., additional, Harbouche, Laid, additional, Bencheikh, Larbi, additional, Lamriben, Larbie, additional, Hanafi, Latifa, additional, Parvez, Laura Braun, additional, Champion, Laure, additional, Croze, Laure, additional, Eprinchard, Laure, additional, Patrier, Laure, additional, Nicolet, Laurence, additional, Vrigneaud, Laurence, additional, Duflot, Laurent, additional, Mackaya, Leandre, additional, Chenine, Leila, additional, Odry, Leon, additional, Tamiji, Lili Taghipour, additional, Bouzar, Lilia Antri, additional, Nga Messi, Liliane Ngango, additional, Le Mouellic, Lionel, additional, Mandart, Lise, additional, Weis, Lise, additional, Pouteau, Lise Marie, additional, Georgieva, Lora, additional, Vitanova, Lorita, additional, Chalabi, Lotfi, additional, Delvallez, Luc, additional, Fromentin, Luc, additional, Marty, Luc, additional, Monjot, Luc, additional, Spataru, Luciana, additional, Bessenay, Lucie, additional, Boissinot, Lucie, additional, Wajsbrot, Lucie, additional, Rakoff, Lucien, additional, Lebourg, Ludivine, additional, Perez, Lydie, additional, Lafage, Lyliane, additional, Azzouz, Lynda, additional, Dumoulin, Madeleine, additional, Ouziala, Messaoud, additional, Joseph, Maan, additional, Brahimi, Mabrouk, additional, Fat, Maeva Wong, additional, Fort, Magalie, additional, Nakhla, Magued, additional, Abtahi, Mahdi, additional, Albadawy, Mahen, additional, Alouach, Mahmoud, additional, Mezghani, Mahmoud, additional, Daroux, Maite, additional, Boukelmoune, Maklouf, additional, Dhib, Malek, additional, Touam, Malik, additional, Dubau, Malina, additional, Balde, Mamadou, additional, Khoa, Man Nguyen, additional, Ismer, Manfred, additional, Mehdi, Manolie, additional, Laforet, Manon, additional, Bouiller, Marc, additional, Eugene, Marc, additional, Fila, Marc, additional, Hazzan, Marc, additional, Kribs, Marc, additional, Ladriere, Marc, additional, Lebot, Marc, additional, Padilla, Marc, additional, Souid, Marc, additional, Marraoui, Marcel, additional, Burbach, Maren, additional, Manescu, Maria, additional, Noguera Gonzalez, Maria Eugenia, additional, Revenco, Mariana, additional, Terrasse, Marianne, additional, Essi, Marie, additional, Macher, Marie Alice, additional, Nogier, Marie Beatrice, additional, Cazin, Marie Cecile, additional, Schweitzer Camoin, Marie Christine, additional, Thouret, Marie Christine, additional, Hannaert, Marie Claude, additional, Servel, Marie France, additional, Chabannier, Marie Helene, additional, Coudert Krier, Marie Jeanne, additional, Catoliquot, Marie Noelle, additional, Guillodo, Marie Paule, additional, Gavard, Marie Sophie, additional, Vairon Codaccioni, Marie Xaviere, additional, Rabec, Marina, additional, Freist, Marine, additional, Gauthier, Marion, additional, Lemaire, Marion, additional, Mehrenberger, Marion, additional, Venot, Marion, additional, Pongas, Marios, additional, Diant, Marlene Beaubrun, additional, Levannier, Martial, additional, Bertaux, Martine, additional, Jablonski, Mathieu, additional, Sacquepee, Mathieu, additional, Dargelos, Mathilde, additional, Lemoine, Mathilde, additional, Tamain, Mathilde, additional, Monge, Matthieu, additional, Reberolle, Matthieu, additional, Cousin, Maud, additional, Francois, Maud, additional, Baron, Maurice, additional, Hoffmann, Maxime, additional, Ingwiller, Maxime, additional, Touzot, Maxime, additional, Mohajer, Mederick, additional, Maaz, Mehadji, additional, Hanoy, Melanie, additional, Marroc, Melanie, additional, Cuny, Melodie, additional, Van Der Straaten, Menno, additional, Serveaux, Mf., additional, Basteri, Michel, additional, Chong, Michel Fen, additional, Hecht, Michel, additional, Massad, Michel, additional, Normand, Michel, additional, Olmer, Michel, additional, Tolani, Michel, additional, Tsimaratos, Michel, additional, Hemery, Michele, additional, Kessler, Michele, additional, Esposito, Miguel, additional, Shenouda, Milad, additional, Kareche, Mimi, additional, Khalili, Mina, additional, Diaconita, Mirella, additional, Rifard, Mohamad Khair, additional, Aladib, Mohamed, additional, Belmouaz, Mohamed, additional, Brahim, Mohamed, additional, Diouani, Mohamed, additional, Cherif, Mohamed Fodil, additional, Jamali, Mohamed, additional, Maghlaoua, Mohamed, additional, Meddeb, Mohamed, additional, Ramdane, Mohamed, additional, Rifaat, Mohamed, additional, Islam, Mohamed Sharifull, additional, Abbade, Mohamed Adnan, additional, Amrandi, Mokhtar, additional, Chawki, Mokhtar, additional, Ciobotaru, Monica, additional, Indrieis, Monica, additional, Chanas, Monique, additional, Hoarau, Monique, additional, Tomeh, Monzer, additional, Bellou, Moufida, additional, Bouzernidj, Mouloud, additional, Ammor, Mounia, additional, Guergour, Mounir, additional, Benzakour, Mountassir, additional, Hachicha, Mourad, additional, Coulibaly, Moussa, additional, Smati, Mustafa, additional, Al Morabiti, Mustapha, additional, Amirou, Mustapha, additional, Isnard, Myriam, additional, Pastural, Myriam, additional, Pujo, Myriam, additional, Boumendjel, Nourredine, additional, Majbri, Nabil, additional, Goumri, Nabila, additional, Mingat, Nadege, additional, Bassilios, Nader, additional, Kerkeni, Nadia, additional, Sedrati, Nadia, additional, Soltani, Nadia, additional, Maroun, Nadine, additional, Neyrat, Nadine, additional, Luang, Nahn, additional, El Esper, Najeh, additional, Ammar, Naji, additional, Ghali, Nasredine, additional, Hamdini, Nasser, additional, Noel, Natacha, additional, Potelune, Natacha, additional, Maisonneuve, Nathalie, additional, Pertuiset, Nathalie, additional, Raynal, Nathalie, additional, Vittoz, Nathalie, additional, Terki, Nazim, additional, Castin, Nelly, additional, Nankeu, Nestor, additional, Bouvier, Nicolas, additional, Keller, Nicolas, additional, Legros, Nicolas, additional, Peters, Nicolas, additional, Quirin, Nicolas, additional, Lefrancois, Nicole, additional, Monnier, Nicole, additional, Rance, Nicole, additional, Bruckmann, Niels, additional, Mertens, Noel, additional, Lorcy, Nolwenn, additional, Gilbert, Olivia, additional, Coldefy, Olivier, additional, Drouineau, Olivier, additional, Dunand, Olivier, additional, Fritz, Olivier, additional, Imhoff, Olivier, additional, Kourilsky, Olivier, additional, Lavelle, Olivier, additional, Papin, Olivier, additional, Roques, Olivier, additional, Le Maner, Ophelie, additional, Benbrahim, Oussamah Fikri, additional, Erina Torres, Pablo Antonio, additional, Urena Torres, Pablo Antonio, additional, Malvezzi, Paolo, additional, Bindi, Pascal, additional, Cluzel, Pascal, additional, Fontanier, Pascal, additional, Wheatley, Pascal, additional, Depraetre, Pascale, additional, Dubosq, Pascale, additional, Halin, Pascale, additional, Sebahoun, Pascale, additional, Siohan, Pascale, additional, Testevuide, Pascale, additional, Deteix, Patrice, additional, Nolen, Patrice, additional, Hue, Patricia, additional, Lemarchand, Patricia, additional, Donnadieu, Patrick, additional, Fievet, Patrick, additional, Fohrer, Patrick, additional, Francais, Patrick, additional, Giraud, Patrick, additional, Hallonet, Patrick, additional, Henri, Patrick, additional, Michaut, Patrick, additional, Niaudet, Patrick, additional, Pauly, Patrick, additional, Thomas, Patrick, additional, Deleaval, Patrik, additional, Finielz, Paul, additional, Stroumza, Paul, additional, Yverneau, Paule Hardy, additional, Caillard, Pauline, additional, Palacin, Pedro, additional, Aubertin, Perrine, additional, Attias, Philippe, additional, Chauveau, Philippe, additional, Coindre, Philippe, additional, Coste, Philippe, additional, Dubot, Philippe, additional, Fournier, Philippe, additional, Hiernaux, Philippe, additional, Jousset, Philippe, additional, Yue Wah, Philippe Lan, additional, Lang, Philippe, additional, Le Cacheux, Philippe, additional, Dupont, Philippe Martin, additional, Michel, Philippe, additional, Mirgaine, Philippe, additional, Moriniere, Philippe, additional, Nicoud, Philippe, additional, Rieu, Philippe, additional, Rousseau, Philippe, additional, Sporer, Philippe, additional, Thorel, Philippe, additional, Vanhille, Philippe, additional, Vigeral, Philippe, additional, Zaoui, Philippe, additional, Bataille, Pierre, additional, Brignon, Pierre, additional, Filipozzi, Pierre, additional, Housset, Pierre, additional, Peyronnet, Pierre, additional, Ramperez, Pierre, additional, Vautrin, Pierre, additional, Michel, Pierre Alexandre, additional, Westeel, Pierre Francois, additional, Carron, Pierre Louis, additional, Durand, Pierre Yves, additional, Parent, Pierrot, additional, Seniuta, Piotr, additional, Kuentz, François, additional, Fraoui, Rabah, additional, Tetaz, Rachel, additional, Amaria, Rachid, additional, Bourouma, Rachid, additional, Djeffal, Rachid, additional, Nebbad, Rachida, additional, Allal, Radia, additional, Dimulescu, Radu, additional, Boustani, Rafaat, additional, Mesbah, Rafik, additional, Makdassi, Raifat, additional, Diab, Raji, additional, Puslenghea, Raluca, additional, Roura, Raoul, additional, Khayat, Rateb, additional, Azar, Raymond, additional, Frayssinet, Raymond, additional, Monkam, Regine, additional, Boulahrouz, Rehouni, additional, Boudet, Remi, additional, Demontis, Renato, additional, Gansey, Renaud, additional, Cuvelier, Rene, additional, Schmitt, Renee, additional, Noordally, Reschad, additional, Binaut, Reynald, additional, Latif, Rezkallah, additional, Dufresne, Richard, additional, Montagnac, Richard, additional, Reade, Richard, additional, Genin, Robert, additional, Novo, Robert, additional, Fickl, Rocsana, additional, Dufresne, Roger, additional, Magnol, Roger, additional, Issautier, Roland, additional, Mortelette, Romain, additional, Delaval, Ronan, additional, Lohro, Ronan, additional, M'barga, Roseline, additional, Beau, S., additional, Dupuis, Clémentine, additional, Vidil, Marie Jacques, additional, Hacini, Sabria, additional, Dahmoune, Said, additional, Lekhal, Saliha, additional, Sakso, Salima Ahriz, additional, Saksi, Salima, additional, Citarda, Salvatore, additional, Boubenider, Samir, additional, Kassis, Samuel, additional, Verhille, Sandra, additional, Genestier, Sandrine, additional, Muller, Sandrine, additional, Krid, Saoussen, additional, Richter, Sarah, additional, Delbes, Sebastien, additional, Mailliez, Sebastien, additional, Veillon, Sebastien, additional, Nony, Sébastien, additional, Benarbia, Seddick, additional, Beaudreuil, Severine, additional, Benyaghla, Sidi Ali, additional, Duquennoy, Simon, additional, Baluta, Simona, additional, Boncila, Simona, additional, Mzoughi, Sonia, additional, Ribal, Sonia, additional, Acamer, Sophie, additional, Chauvet, Sophie, additional, Girerd, Sophie, additional, Ozenne, Sophie, additional, Parahy, Sophie, additional, Duval, Sophie Rubens, additional, Taque, Sophie, additional, Menouer, Soraya, additional, Chargui, Soumaya, additional, Bataille, Stanislas, additional, Barbier, Stephane, additional, Billion, Stephane, additional, Roueff, Stephane, additional, Torner, Stephane, additional, Martin, Stephane Jean, additional, Coupel, Stephanie, additional, Cloarec, Sylvie, additional, Lavaud, Sylvie, additional, Leou, Sylvie, additional, Chatelet, T., additional, Onesta, Tania, additional, Benhabib, Tassadit, additional, Bensalem, Tayeb, additional, Dimulescu, Theodora, additional, Sawadogo, Theophile, additional, Hitze, Thibault Dolley, additional, Baranger, Thierry, additional, Boudemaghe, Thierry, additional, Hannedouche, Thierry, additional, Krummel, Thierry, additional, Milcent, Thierry, additional, Dervaux, Thomas, additional, Guincestre, Thomas, additional, Kofman, Thomas, additional, Raphael, Thomas, additional, Sadreux, Thomas, additional, Ulinski, Tim, additional, Roger, Tiphaine Guyon, additional, Serrato, Tomas, additional, Kofman, Tomek, additional, Wong, Tony, additional, Boubia, Toufik, additional, Gbindoun, Ubald Assogba, additional, Khuzaie, Usama, additional, Caudwell, Valerie, additional, Chatelet, Valerie, additional, Crougneau, Valerie, additional, De Precigout, Valerie, additional, Drouillat, Valerie, additional, Galantine, Valerie, additional, Hugot, Valerie Granveau, additional, Leroy, Valerie, additional, Boubia, Veronique, additional, Falque, Veronique, additional, Fournier, Veronique, additional, Queron, Veronique, additional, Viviani, Veronique, additional, Gueuttin, Victor, additional, Panescu, Victor, additional, Calonge, Victorio Menoyo, additional, Nguyen, Viet, additional, Allot, Vincent, additional, Delattre, Vincent, additional, Leduc, Vincent, additional, Pradier, Vincent, additional, Aglae, Violaine Emal, additional, Badulescu, Viorica, additional, Molina, Virginia, additional, Besson, Virginie, additional, Chaigne, Virginie, additional, Jaber, Waddah, additional, Boudi, Wael, additional, El Haggan, Wael, additional, Guillon, Wen Qin, additional, Aneni, Wided Tabbi, additional, Hanf, William, additional, Kohn, Wladimir, additional, Bellenfant, Xavier, additional, Gaudry, Xavier Moreau, additional, Delmas, Yahsou, additional, Knefati, Yannick, additional, Saingra, Yannick, additional, Tirolien, Yannick, additional, Mann, Youssef, additional, Brunak, Yvan, additional, Dimitrov, Yves, additional, Doussy, Yves, additional, Tanter, Yves, additional, Benabid, Zaid, additional, Soltani, Zaara, additional, Boukerroucha, Zacharia, additional, Takla, Zafer, additional, Ramanantsialonina, Zana, additional, Dickson, Zara, additional, Tubail, Zead, additional, Pour, Zoe Koochaki, additional, Boukhalfa, Zohra, additional, and Jacquot, Zohra, additional

Published
2020
Full Text
View/download PDF

28. Factors associated with global longitudinal strain decline in hypertensive patients with normal left ventricular ejection fraction

Author

Latefa Henaoui, Souhila Ouabdesselam, Abderrahim Meziane-Tani, S. Benkhedda, Nabila Soufi Taleb Bendiab, Nadera Methia, Samia Latreche, and Jean-Jacques Monsuez

Subjects
Male, medicine.medical_specialty, Epidemiology, Diastole, Blood Pressure, 030204 cardiovascular system & hematology, Overweight, Left ventricular hypertrophy, Ventricular Function, Left, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, Diabetes Mellitus, Odds Ratio, Humans, Medicine, 030212 general & internal medicine, Aged, Dyslipidemias, Univariate analysis, Ejection fraction, Ventricular Remodeling, business.industry, Stroke Volume, Odds ratio, Middle Aged, medicine.disease, Myocardial Contraction, Echocardiography, Doppler, Cross-Sectional Studies, Early Diagnosis, Logistic Models, Blood pressure, Algeria, Hypertension, Multivariate Analysis, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Dyslipidemia
Abstract

Background Early detection of risk factors for left ventricular (LV) dysfunction may be useful in patients with high blood pressure (HBP). Methods Patient from an outpatient HBP clinic underwent a two-dimensional Doppler-coupled echocardiography with determination of LV global longitudinal strain (GLS) by speckle-tracking. Results Among 200 patients (mean age 61.7 ± 9.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP. LV hypertrophy (LVH) was found in 136 patients (68%), including concentric (n = 106) and eccentric (n = 30) LVH. Diastolic dysfunction patterns were observed in 178 patients (89%), and increased filling pressures were observed in 37 patients (18.5%). GLS ranged from –25% to –11.6% (mean –16.9 ± 3.2%). Low GLS values (>–17%) were found in 91 patients (45.5%), 68 with and 23 without LVH. In univariate analysis, a reduced GLS was associated with HBP lasting for >10 years (odds ratio (OR) = 3.51, 95% confidence interval (CI) 1.73–7.09; p = 0.002), uncontrolled HBP (OR = 3.55, 95% CI 1.96–6.43; p Conclusion Early impairment of LV function, detected by a reduced GLS, is associated with long-lasting, uncontrolled HBP, overweight, related metabolic changes, and is more pronounced in patients with LVH.

Published
2017
Full Text
View/download PDF

29. The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis

Author

Nihal Martis, Virginie Magnone, Franck Broly, Bruno Crestani, Pascal Barbry, Nicolas Nottet, Elisabeth Courcot, Nicolas Pottier, Imène-Sarah Henaoui, Grégoire Savary, Nicolas Pons, Roger Rezzonico, Benoit Wallaert, Bernard Mari, Kevin Lebrigand, Agnès Paquet, Matthieu Buscot, Véronique Hofman, Michael Perrais, François Glowacki, Julien Fassy, Cynthia Van der Hauwaert, Paul Hofman, Charles-Hugo Marquette, Sylvie Leroy, Edmone Dewaeles, Georges Vassaux, Christian L. Lino Cardenas, Andreas Günther, Christelle Cauffiez, Saverio Bellusci, Serena Diazzi, Julie Lemaire, Thierry Brousseau, Laurent Plantier, Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Faculté de Médecine H. Warembourg, EA 2679, Institut de pharmacologie moléculaire et cellulaire (IPMC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis - Faculté de Médecine (UNS UFR Médecine), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Infection bactérienne, inflammation, et carcinogenèse digestive, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Service de Physiologie-Explorations Fonctionnelles, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Targeted Therapy Laboratory, Section of Cell and Molecular Biology, The Institute of Cancer Research, Immunité muqueuse et vaccination, Institut National de la Santé et de la Recherche Médicale (INSERM), Konrad-Zuse-Zentrum für Informationstechnik Berlin (ZIB), Zuse Institute Berlin (ZIB), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Biologie et physiopathologie cutanées : expression génique, signalisation et thérapie, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), Biochimie Automatisée [Lille] (UF Analyses automatisée de Biochimie), Department of Internal Medicine II [Giessen, Germany] (Cardio-Pulmonary Institute), University of Giessen Lung Center [Giessen, Germany], Laboratoire de Toxicologie, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC)-Université Côte d'Azur (UCA), Faculté de Médecine Henri Warembourg - Université de Lille, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Impact de l'environnement chimique sur la santé humaine (IMPECS), Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut des Sciences de la Terre de Paris (iSTeP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS)

Subjects
Pulmonary and Respiratory Medicine, [SDV]Life Sciences [q-bio], Caveolin 1, Smad Proteins, SMAD, Critical Care and Intensive Care Medicine, Transcriptome, 03 medical and health sciences, Idiopathic pulmonary fibrosis, Mice, 0302 clinical medicine, Transforming Growth Factor beta, microRNA, Pulmonary fibrosis, medicine, Animals, Myofibroblasts, Wnt Signaling Pathway, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, business.industry, Editorials, Fibroblasts, medicine.disease, Long non-coding RNA, Idiopathic Pulmonary Fibrosis, 3. Good health, MicroRNAs, 030220 oncology & carcinogenesis, Cancer research, RNA, Long Noncoding, business, Myofibroblast, Transforming growth factor, Signal Transduction
Abstract

Rationale: Given the paucity of effective treatments for idiopathic pulmonary fibrosis (IPF), new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies. TGF-β (transforming growth factor-β) is the main profibrotic factor, but its inhibition is associated with severe side effects because of its pleiotropic role. Objectives: To determine if downstream noncoding effectors of TGF-β in fibroblasts may represent new effective therapeutic targets whose modulation may be well tolerated. Methods: We investigated the whole noncoding fraction of TGF-β-stimulated lung fibroblast transcriptome to identify new genomic determinants of lung fibroblast differentiation into myofibroblasts. Differential expression of the long noncoding RNA (lncRNA) DNM3OS (dynamin 3 opposite strand) and its associated microRNAs (miRNAs) was validated in a murine model of pulmonary fibrosis and in IPF tissue samples. Distinct and complementary antisense oligonucleotide-based strategies aiming at interfering with DNM3OS were used to elucidate the role of DNM3OS and its associated miRNAs in IPF pathogenesis. Measurements and Main Results: We identified DNM3OS as a fibroblast-specific critical downstream effector of TGF-β-induced lung myofibroblast activation. Mechanistically, DNM3OS regulates this process in trans by giving rise to three distinct profibrotic mature miRNAs (i.e., miR-199a-5p/3p and miR-214-3p), which influence SMAD and non-SMAD components of TGF-β signaling in a multifaceted way. In vivo, we showed that interfering with DNM3OS function not only prevents lung fibrosis but also improves established pulmonary fibrosis. Conclusions: Pharmacological approaches aiming at interfering with the lncRNA DNM3OS may represent new effective therapeutic strategies in IPF.

Published
2019
Full Text
View/download PDF

31. Impact of Diabetes on Cardiac Function in Patients with High Blood Pressure

Author

S. Benkhedda, Marilucy Lopez-Sublet, Nabila Soufi Taleb Bendiab, Jean-Jacques Monsuez, Souhila Ouabdesselam, and Latefa Henaoui

Subjects
Cardiac function curve, medicine.medical_specialty, hypertension, endocrine system diseases, Health, Toxicology and Mutagenesis, Concentric hypertrophy, Blood Pressure, Type 2 diabetes, 030204 cardiovascular system & hematology, Article, Ventricular Function, Left, left ventricular function, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, medicine, Humans, 030212 general & internal medicine, Aged, Subclinical infection, Ejection fraction, diabetes, business.industry, Public Health, Environmental and Occupational Health, Stroke Volume, Middle Aged, medicine.disease, Blood pressure, Diabetes Mellitus, Type 2, Echocardiography, Cardiology, Medicine, business, Body mass index, global longitudinal strain
Abstract

Background: Although the combination of high blood pressure (HBP) and type 2 diabetes (T2DM) increases the risk of left ventricular (LV) dysfunction, the impact of T2DM on LV geometry and subclinical dysfunction in hypertensive patients and normal ejection fraction (EF) has been infrequently evaluated. Methods: Hypertensive patients with or without T2DM underwent cardiac echocardiography coupled with LV global longitudinal strain (GLS) assessment. Results: Among 200 patients with HBP (mean age 61.7 ± 9.7 years) and EF &gt, 55%, 93 had associated T2DM. Patients with T2DM had a higher body mass index (29.9 ± 5.1 kg/m2 vs. 29.3 ± 4.7 kg/m2, p = 0.025), higher BP levels (158 ± 23/95 ± 13 vs. 142 ± 33/87 ± 12 mmHg, p = 0.003), a higher LV mass index (115.8 ± 32.4 vs. 112.0 ± 24.7 g/m2, p = 0.004), and higher relative wall thickness (0.51 ± 0.16 vs. 0.46 ± 0.12, p = 0.0001). They had more frequently concentric remodeling (20.4% vs. 16.8%, p &lt, 0.001), concentric hypertrophy (53.7% vs. 48.6%, p &lt, 0.001), elevated filling pressures (25.8 vs. 12.1%, p = 0.0001), indexed left atrial volumes greater than 28 mL/m2 (17.2 vs. 11.2%, p = 0.001), and a reduced GLS less than −18% (74.2 vs. 47.7%, p &lt, 0.0001). After adjustment for BP and BMI, T2DM remains an independent determinant factor for GLS decline (OR = 2.26, 95% CI 1.11–4.61, p = 0.023). Conclusions: Left ventricular geometry and subclinical LV function as assessed with GLS are more impaired in hypertensive patients with than without T2DM. Preventive approaches to control BMI and risk of T2DM in hypertensive patients should be emphasized.

Published
2021
Full Text
View/download PDF

32. MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib

Author

Patrick Brest, Pascal Barbry, Marius Ilie, Paul Hofman, Sandra Lassalle, Elodie Long, Frédérique Tissier, Joséphine Zangari, Philippe Vielh, Géraldine Lemaire, Imène Sarah Henaoui, Catherine Butori, Alexandra Popa, Olivier Blanck, Christelle Bonnetaud, Hélène Trouette, Nicolas Guevara, Olivier Bordone, Alexandre Bozec, Bernard Mari, Geneviève Belléannée, J.-L. Sadoul, José Santini, Isabelle Peyrottes, Bogdan Catargi, Véronique Hofman, Martine Patey, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), An algorithmic view on genomes, cells, and environments (BAMBOO), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut de la physique de la matière condensée (IPMC), Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nice (CHU Nice), Laboratory of Clinical and Experimental Pathology, Laboratoire d’anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Bordeaux [Bordeaux], Department of Pathology, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), UNICANCER-Université Côte d'Azur (UCA), Service d'Endocrinologie (NICE - Endocrino), Hôpital Pasteur [Nice] (CHU), Institut de pharmacologie moléculaire et cellulaire (IPMC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bayer Cropscience, Pathologie morphologique, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Infection bactérienne, inflammation, et carcinogenèse digestive, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (... - 2019) (UNS), Service de pathologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Service d'Anatomie et cytologie pathologiques = Service de Pathologie [CHU Pitié-Salpêtrière] (ACP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Brest, Patrick

Subjects
Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Vesicular Transport Proteins, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Vandetanib, 0302 clinical medicine, Piperidines, RNA interference, medullary thyroid carcinoma, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, microRNA, treatment, Thyroid, Middle Aged, 3. Good health, [SDV] Life Sciences [q-bio], Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Immunohistochemistry, Female, RNA Interference, Research Paper, medicine.drug, Adult, vandetanib, microRNA-375, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cell Line, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Biomarkers, Tumor, medicine, Humans, Gene silencing, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Thyroid Neoplasms, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Aged, Cell Proliferation, business.industry, Cell growth, Gene Expression Profiling, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Carcinoma, Neuroendocrine, Gene expression profiling, MicroRNAs, 030104 developmental biology, Quinazolines, Cancer research, business
Abstract

In this study, we performed microRNA (miRNA) expression profiling on a large series of sporadic and hereditary forms of medullary thyroid carcinomas (MTC). More than 60 miRNAs were significantly deregulated in tumor vs adjacent non-tumor tissues, partially overlapping with results of previous studies. We focused our attention on the strongest up-regulated miRNA in MTC samples, miR-375, the deregulation of which has been previously observed in a variety of human malignancies including MTC. We identified miR-375 targets by combining gene expression signatures from human MTC (TT) and normal follicular (Nthy-ori 3-1) cell lines transfected with an antagomiR-375 inhibitor or a miR-375 mimic, respectively, and from an in silico analysis of thyroid cell lines of Cancer Cell Line Encyclopedia datasets. This approach identified SEC23A as a bona fide miR-375 target, which we validated by immunoblotting and immunohistochemistry of non-tumor and pathological thyroid tissue. Furthermore, we observed that miR-375 overexpression was associated with decreased cell proliferation and synergistically increased sensitivity to vandetanib, the clinically relevant treatment of metastatic MTC. We found that miR-375 increased PARP cleavage and decreased AKT phosphorylation, affecting both cell proliferation and viability. We confirmed these results through SEC23A direct silencing in combination with vandetanib, highlighting the importance of SEC23A in the miR-375-associated increased sensitivity to vandetanib. Since the combination of increased expression of miR-375 and decreased expression of SEC23A point to sensitivity to vandetanib, we question if the expression levels of miR-375 and SEC23A should be evaluated as an indicator of eligibility for treatment of MTC patients with vandetanib.

Published
2016
Full Text
View/download PDF

33. Facteurs de risque du cancer du sein - Étude cas-témoins Wilaya de Tlemcen, 2015–2017

Author

L. Henaoui and K. Meguenni

Subjects
Epidemiology, Public Health, Environmental and Occupational Health
Abstract

Introduction Le cancer du sein est le premier cancer chez la femme. Son incidence est en nette progression dans le monde en developpement du fait d’une plus longue esperance de vie, due a l’augmentation de l’urbanisation et de l’adoption d’un certain mode de vie occidental. Plusieurs facteurs de risque ont ete clairement mis en evidence. Les facteurs genesiques associes a une exposition prolongee a des œstrogenes endogenes, la puberte precoce, une menopause, premiere grossesse tardive, sont parmi les facteurs les plus importants. L’utilisation de contraceptifs oraux ou un traitement hormonal augmentent le risque, l’allaitement aurait un effet protecteur. En Algerie, sa frequence est en nette augmentation, il atteint de plus en plus la femme jeune. Materiel et methodes Il s’agit d’une etude cas-temoins sur un echantillon de 960 sujets (320 cas incidents durant les deux annees 2015 et 2017 et 640 temoins apparies aux cas selon l’âge et la commune de residence des cas). La saisie des donnees est faite sur EPI info version 6, l’analyse statistique est faite sur le logiciel Stata version 11. Dans chaque groupe nous avons effectue des analyses univariees par des modeles de regression logistique conditionnelle. Les variables liees a la maladie, pour un seuil de signification de 20 %, en analyse univariee ont ete introduites dans le modele final. L’analyse multivariee se realise par des modeles de regression logistique conditionnelle pas a pas (« Stepwise »), Pour l’ensemble des tests statistiques, nous retiendrons un seuil de signification de 5 %. L’estimation des parametres β de chaque variable, repose sur l’application de la methode du maximum de vraisemblance. Ainsi sont egalement fournis, les OR et leurs intervalles de confiance associes a 95 %. Le test de nullite des parametres β fait appel au test de Wald. Tous les tests statistiques sont bilateraux. Resultats L’âge des sujets enquetes est compris entre 23 et 86 ans. L’âge median est de 50 ans et l’âge moyen est de 51,28 ± 12,16 ans. Les femmes celibataires representent respectivement, 11,6 % et 4,6 %, chez les cas et les temoins. Les deux tiers de la population d’etude sont representees par les femmes mariees, constituant ainsi la categorie predominante. Une association positive et significative a ete detectee entre les antecedents du premier degre du cancer du sein et le cancer du sein [rapport de cotes (OR) = 4,98 ; intervalle de confiance a IC 95 % (1,52–16,26)] ; le tabagisme passif et le cancer du sein [OR = 3,58 ; IC 95 % (1,94–6,11)] ; la survenue de la menopause et le cancer du sein [OR = 2,84 ; IC 95 % (1,11–7,21)] et aussi entre le cancer du sein et la duree du cycle > 28 jours [OR = 6,73 ; IC 95 % (3,50–12,94)]. Les femmes mariees ou ayant ete mariees semblent protegees contre le cancer du sein par rapport aux celibataires OR = 0,21 [IC 95 % (0,09–0,47)]. Toutefois, il n’y avait aucune association entre le cancer du sein et les facteurs de reproduction, ainsi que les autres facteurs sociodemographiques et anthropometriques. Conclusion L’investigation et l’analyse ayant trait aux facteurs classiques suggerent un profil epidemiologique et une association forte entre cancer familial et cancer du sein ; quelques questions de recherche pourraient se degager afin d’ameliorer dans le futur, la comprehension de certains phenomenes lies au cancer du sein.

Published
2020
Full Text
View/download PDF

34. Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR

Author

Nakamura Mirai, Basavarajaiah Poornima, Rousset Emilie, Beraud Cyprien, Latreille Daniel, Henaoui Imène-Sarah, Lassot Irina, Mari Bernard, and Kiernan Rosemary

Subjects
LTR, transcription, Tat, Spt6, PAAF1, proteasome, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Tat-mediated activation of the HIV-1 promoter depends upon a proteasome-associated factor, PAAF1, which dissociates 26S proteasome to produce 19S RP that is essential for transcriptional elongation. The effect of PAAF1 on proteasome activity could also potentially shield certain factors from proteolysis, which may be implicated in the transcriptional co-activator activity of PAAF1 towards the LTR. Results Here, we show that Spt6 is targeted by proteasome in the absence of PAAF1. PAAF1 interacts with the N-terminus of Spt6, suggesting that PAAF1 protects Spt6 from proteolysis. Depletion of either PAAF1 or Spt6 reduced histone occupancy at the HIV-1 promoter, and induced the synthesis of aberrant transcripts. Ectopic Spt6 expression or treatment with proteasome inhibitor partially rescued the transcription defect associated with loss of PAAF1. Transcriptional profiling followed by ChIP identified a subset of cellular genes that are regulated in a similar fashion to HIV-1 by Spt6 and/or PAAF1, including many that are involved in cancer, such as BRCA1 and BARD1. Conclusion These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.

Published
2012
Full Text
View/download PDF

35. Therapeutic potential of miRNAs in diabetes mellitus

Author

Ksenia Tugay, Imène Sarah Henaoui, Lisa Stoll, and Romano Regazzi

Subjects
Circulating mirnas, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Biology, Bioinformatics, medicine.disease, Biomarker (cell), Diabetic complication, Potential biomarkers, Diabetes mellitus, microRNA, Immunology, medicine
Abstract

miRNAs are major regulators of gene expression that are emerging as central players in the development of many human diseases, including diabetes mellitus. In fact, the manifestation of diabetes is associated with alterations in the miRNA profile in insulin-secreting cells, insulin target tissues and, in case of long-term diabetes complications, in many additional organs. Diabetes also results in changes in the profile of miRNAs detectable in blood and other body fluids. This has boosted an ever increasing interest in the use of circulating miRNAs as potential biomarkers to predict the development of diabetes and its devastating complications. Moreover, promising approaches to correct the level of selected miRNAs are emerging, permitting to envisage new therapeutic strategies to treat diabetes and its complications.

Published
2018

36. Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases

Author

Franck Broly, Elisabeth Courcot, Roger Rezzonico, Grégoire Savary, Nihal Martis, Sylvie Leroy, Agnès Paquet, Christian L. Lino Cardenas, Matthieu Buscot, Charles-Hugo Marquette, François Glowacki, Nicolas Nottet, Cynthia Van der Hauwaert, Georges Vassaux, Pascal Barbry, Kevin Lebrigand, Nicolas Pottier, Bruno Crestani, Edmone Dewaeles, Benoit Wallaert, Serena Diazzi, Saverio Bellusci, Julien Fassy, Michael Perrais, Imène Sarah Henaoui, Christelle Cauffiez, Thierry Brousseau, Laurent Plantier, and Bernard Mari

Subjects
0303 health sciences, Cell type, Lung, Effector, business.industry, SMAD, medicine.disease, 3. Good health, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, medicine, Fibroblast, business, Myofibroblast, Function (biology), 030304 developmental biology
Abstract

Given the paucity of effective treatments for fibrotic disorders, new insights into the deleterious mechanisms controlling fibroblast activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies. Here, we identified the long non-coding RNA DNM3OS as a critical downstream effector of TGF-β-induced myofibroblast activation. Mechanistically, DNM3OS regulates this process in trans by giving rise to 3 distinct profibrotic mature miRNAs (i.e. miR-199a-5p/3p and miR-214-3p), which influence both SMAD and non-SMAD components of TGF-β signaling in a multifaceted way, through two modes of action consisting of either signal amplification or mediation. Finally, we provide preclinical evidence that interfering with DNM3OS function using distinct strategies not only prevents lung and kidney fibrosis but also improves established lung fibrosis, providing thus a novel paradigm for the treatment of refractory fibrotic diseases such as idiopathic pulmonary fibrosis.One Sentence SummaryThe DNM3OS lncRNA is a reservoir of fibromiRs with major functions in fibroblast response to TGF-β and represents a valuable therapeutic target for refractory fibrotic diseases such as idiopathic pulmonary fibrosis (IPF).

Published
2018
Full Text
View/download PDF

37. The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis

Author

Savary, Grégoire, primary, Dewaeles, Edmone, additional, Diazzi, Serena, additional, Buscot, Matthieu, additional, Nottet, Nicolas, additional, Fassy, Julien, additional, Courcot, Elisabeth, additional, Henaoui, Imène-Sarah, additional, Lemaire, Julie, additional, Martis, Nihal, additional, Van der Hauwaert, Cynthia, additional, Pons, Nicolas, additional, Magnone, Virginie, additional, Leroy, Sylvie, additional, Hofman, Véronique, additional, Plantier, Laurent, additional, Lebrigand, Kevin, additional, Paquet, Agnès, additional, Lino Cardenas, Christian L., additional, Vassaux, Georges, additional, Hofman, Paul, additional, Günther, Andreas, additional, Crestani, Bruno, additional, Wallaert, Benoit, additional, Rezzonico, Roger, additional, Brousseau, Thierry, additional, Glowacki, François, additional, Bellusci, Saverio, additional, Perrais, Michael, additional, Broly, Franck, additional, Barbry, Pascal, additional, Marquette, Charles-Hugo, additional, Cauffiez, Christelle, additional, Mari, Bernard, additional, and Pottier, Nicolas, additional

Published
2019
Full Text
View/download PDF

39. Experimental and Numerical Analysis of the Rheology of Self-compacting Concrete Using a Vane Rheometer.

Author

Taleb, Omar, Ghomari, Fouad, Boukli Hacene, Mohammed Amine, Henaoui, Mustapha, and Soualhi, Hamza

Subjects
SELF-consolidating concrete, NUMERICAL analysis, RHEOLOGY, COMPUTATIONAL fluid dynamics, HERSCHEL-Bulkley model, CONCRETE mixing
Abstract

Vane rheometers are widely used in determining the rheological properties of concrete. However, the geometry of the vane can have an impact on stress calculation. This research falls within this context. Indeed, an experimental study, using a rheometer with an inverted double U-shaped vane, was carried out to study the rheological behavior of self-compacting concrete (SCC) with different granular skeletons. The accuracy of the results was then discussed with respect to the distributions of pressures, stresses and shear rates within the gap, by conducting Computational Fluid Dynamics (CFD) simulations. The experimental results obtained showed that SCC has a nonlinear behavior which can be described by the Herschel-Bulkley model. In addition, a ratio (gravel/sand) close to 1 could ensure a low shear threshold and a sufficient viscosity to avoid segregation. In addition, numerical simulations showed that the shape of the blade used can generate depression areas which can affect the global stress value. Moreover, it was found more interesting to round the bottom corners of the blades in order to reduce the risk of segregation. Numerical analysis also revealed that the rheometer used can also provide suitable shear rates for concrete mixing or pumping studies. [ABSTRACT FROM AUTHOR]

Published
2021

40. PIWI-interacting RNAs as novel regulators of pancreatic beta cell function

Author

Lena Eliasson, Inês G. Mollet, Jonathan Sobel, Romano Regazzi, Imène Sarah Henaoui, Claudiane Guay, and Cécile Jacovetti

Subjects
Male, 0301 basic medicine, endocrine system, Somatic cell, Endocrinology, Diabetes and Metabolism, Piwi-interacting RNA, Biology, Rats, Sprague-Dawley, Islets of Langerhans, 03 medical and health sciences, Insulin-Secreting Cells, Insulin Secretion, Internal Medicine, medicine, Animals, Insulin, Gene silencing, RasiRNA, RNA, Small Interfering, Rats, Wistar, Cell Proliferation/physiology, Diabetes Mellitus, Type 2/metabolism, Female, Gene Expression Profiling, Insulin/secretion, Insulin-Secreting Cells/metabolism, Islets of Langerhans/metabolism, RNA, Small Interfering/metabolism, Rats, Diabetes, Insulin secretion, Pancreatic islets, Piwil genes, piRNAs, Cell Proliferation, Genetics, Microarray analysis techniques, urogenital system, Cell biology, Gene expression profiling, 030104 developmental biology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Beta cell
Abstract

P-element induced Wimpy testis (PIWI)-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and guide them to silence transposable elements. They are abundantly expressed in germline cells and play key roles in spermatogenesis. There is mounting evidence that piRNAs are also present in somatic cells, where they may accomplish additional regulatory tasks. The aim of this study was to identify the piRNAs expressed in pancreatic islets and to determine whether they are involved in the control of beta cell activities. piRNA profiling of rat pancreatic islets was performed by microarray analysis. The functions of piRNAs were investigated by silencing the two main Piwi genes or by modulating the level of selected piRNAs in islet cells. We detected about 18,000 piRNAs in rat pancreatic islets, many of which were differentially expressed throughout islet postnatal development. Moreover, we identified changes in the level of several piRNAs in the islets of Goto–Kakizaki rats, a well-established animal model of type 2 diabetes. Silencing of Piwil2 or Piwil4 genes in adult rat islets caused a reduction in the level of several piRNAs and resulted in defective insulin secretion and increased resistance of the cells to cytokine-induced cell death. Furthermore, overexpression in the islets of control animals of two piRNAs that are upregulated in diabetic rats led to a selective defect in glucose-induced insulin release. Our results provide evidence for a role of PIWI proteins and their associated piRNAs in the control of beta cell functions, and suggest a possible involvement in the development of type 2 diabetes. Data have been deposited in Gene Expression Omnibus repository under the accession number GSE93792. Data can be accessed via the following link: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=ojklueugdzehpkv&acc=GSE93792

Published
2017

41. The DNM3OS lncRNA is a reservoir of fibromiRs with major functions in lung fibroblast response to TGF-β and pulmonary fibrogenesis

Author

Franck Broly, Nihal Martis, Edmone Dewaeles, Pascal Barbry, Agnès Paquet, Sylvie Leroy, Laurent Plantier, Bruno Crestani, Cynthia Van der Hauwaert, François Glowacki, Christelle Cauffiez, Nicolas Nottet, Nicolas Pottier, Kevin Lebrigand, Saverio Bellusci, Serena Diazzi, Christian L. Lino Cardenas, Julien Fassy, Roger Rezzonico, Bernard Mari, Charles-Hugo Marquette, Matthieu Buscot, Grégoire Savary, Imène-Sarah Henaoui, and Michael Perrais

Subjects
Lung Disorder, Cell type, medicine.anatomical_structure, Lung, business.industry, microRNA, Cancer research, RNA, Medicine, business, Fibroblast, Phenotype, Transforming growth factor
Abstract

Non-coding RNAs have recently gained widespread attention given their broad implication in the initiation and progression of various complex diseases. Whereas previous studies on fibrotic lung disorders, especially the idiopathic form (IPF), have mainly focused on miRNAs, the precise contribution of other class of non-coding RNAs in lung fibrogenesis is unclear. Given the paucity of effective treatment in IPF, new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies for this devastating disease. Here we identify a long non-coding RNA, termed DNM3OS, which tightly controls the various cellular and molecular phenotypic changes occurring during lung fibroblast activation in response to TGF-β. Notably, DNM3OS regulates these processes in trans by giving rise to 3 distinct profibrotic miRNAs (i.e. miR-199a-5p/3p and miR-214-3p), which repress distinct but functionally related targets within TGF-β signaling cascade. Finally, we provide in vivo evidence that interfering with DNM3OS function may be a promising strategy for the treatment of lethal fibrotic diseases such as IPF.

Published
2017
Full Text
View/download PDF

42. Study on Solar Air Collector with Perforated Strips in the Baffles

Author

Mustapha Henaoui and Khaled Aliane

Subjects
Finite volume method, Materials science, Turbulence, Mechanical Engineering, Baffle, Insulator (electricity), Mechanics, STRIPS, Nusselt number, law.invention, Physics::Fluid Dynamics, law, Compressibility, Working fluid
Abstract

In this paper, a three-dimensional study of incompressible turbulent flow through a canal of a solar air collector has been carried out. The canal is provided with two solid baffles in the first case and two perforated baffles in the second case fixed on the absorber and the insulator. The models of the perforations are in the forms of perforated strips in the baffles and they have a diameter of d=0.005m; their number is 12 per baffle. The working fluid used is air. The form and the position of its perforations allow the creation of secondary flows with the orientation of the flow towards the absorber. The numerical resolution of the transport equations is carried out by using the finite volume method and the k-( turbulent model. The results are compared with experimental data. The evolution of axial velocity fields, the pressure coefficients fields, the friction coefficients profiles, the local Nusselt numbers profiles and the temperature distribution profiles are discussed in this work.

Published
2019
Full Text
View/download PDF

44. Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases

Author

Savary, G., primary, Buscot, M., additional, Dewaeles, E., additional, Diazzi, S., additional, Nottet, N., additional, Courcot, E., additional, Fassy, J., additional, Lebrigand, K., additional, Henaoui, I. S., additional, Martis, N., additional, Van der Hauwaert, C., additional, Leroy, S., additional, Plantier, L., additional, Paquet, A., additional, Lino Cardenas, C. L., additional, Vassaux, G., additional, Crestani, B., additional, Wallaert, B., additional, Rezzonico, R., additional, Brousseau, T., additional, Glowacki, F., additional, Bellusci, S., additional, Perrais, M., additional, Broly, F., additional, Barbry, P., additional, Marquette, C. H., additional, Cauffiez, C., additional, Mari, B., additional, and Pottier, N., additional

Published
2018
Full Text
View/download PDF

47. An elliptic system modeling two subpopulations

Author

Ouassila Henaoui

Subjects
Applied Mathematics, Mathematical analysis, General Engineering, Fixed-point theorem, General Medicine, Systems modeling, Computational Mathematics, Maximum principle, Quantitative Biology::Populations and Evolution, Applied mathematics, Uniqueness, General Economics, Econometrics and Finance, Analysis, Mathematics
Abstract

In this paper we study an elliptic system modeling two subpopulations of the same species competing for resources. We show the existence and uniqueness of coexistence states of the system by giving necessary and sufficient conditions.

Published
2012
Full Text
View/download PDF

48. The current state of the plant diversity in the Tlemcen region (Northwest Algeria)

Author

Mohammed Bouazza and Smaïn El-Amine Henaoui

Subjects
Mediterranean climate, Current (stream), Geography, Ecology, Biodiversity, Plant species, Ecosystem, Stratification (vegetation), Vegetation, Plant diversity
Abstract

Tlemcen region is characterized by a Mediterranean climate, with a remarkable vegetal cover. The latter is influenced by the anthropozoological action. For that, we realized a phytoecological study based on the minimum area classical method [1] which allows us to have a good overview on plant biodiversity and better analyze and interpret the vegetation at different levels (systematic composition; biological, morphological and biogeographical characterizations; stratification; and plant species inventory which we hope comprehensive). The results show that our ecosystems are disrupted because therophytisation, before last vegetation dynamics element [2], settles giving up a few feet of cork and holm oaks species of ancient forest.

Published
2012
Full Text
View/download PDF

49. Assessment of the study of longitudinal systolic function by 2D strain in hypertensive patients with preserved LVEF

Author

Abderrahim Meziane-Tani, S. Benkhedda, L. Henaoui, and N. Taleb-Bendiab

Subjects
medicine.medical_specialty, education.field_of_study, Ejection fraction, business.industry, Population, Diastole, Concentric hypertrophy, medicine.disease, Blood pressure, Internal medicine, Diabetes mellitus, Heart failure, Cardiology, Medicine, cardiovascular diseases, Risk factor, Cardiology and Cardiovascular Medicine, business, education
Abstract

Introduction Hypertension is a risk factor for cardiovascular disease. It causes LV hypertrophy (LVH). LVH as well as patterns of abnormal geometry have been associated with adverse outcomes. Global longitudinal strain (GLS) has been used to detect early subclinical myocardial dysfunction in a broad spectrum of cardiac conditions and provides a novel approach for LV risk assessment in patients with hypertension. Purpose Assess the clinical and echocardiographic factors associated with and predictive for early impairment of left ventricular function as assessed using GLS evaluation in hypertensive patients. Methods Cross-sectional descriptive study, with a number of 130 hypertensive and with the objective of evaluating the study of longitudinal function by 2D strain in patients with systemic hypertension with preserved LVEF and the determination of predictors factors of the decrease GLS in this population. A complete study echo cardiographic, including LVEF biplane Simpson method, calculation of left ventricular mass indexed and relative parietal thickness, analysis diastolic function and the study of longitudinal strain of the LV. Results The prevalence of (LVH) was 66%. 49% presented a concentric hypertrophy, 73% had a relative wall thickness (RWT) > 0.42.18% had severe diastolic dysfunction with elevation in filling pressure. The mean GLS was found to be −16.9 ± 3.2%, low GLS values (> −17%) were found in 45.5% of the general population. In particular, 34.4% of the patients had no LVH and 50.7% of them presented LVH. Statistical analysis revealed significant correlation between the decrease in GLS and diabetes, the values of blood pressure and elevated filling pressures. Conclusion The evaluation of longitudinal systolic function by 2D strain provides new insight of myocardial function in hypertension that could improve the pathophysiological understanding and identify high-risk heart failure patients eligible for preventive strategies.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results