15 results on '"Hemmes S.N.T."'
Search Results
2. Ventilation and outcomes following robotic-assisted abdominal surgery: an international, multicentre observational study
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Queiroz, Veronica N.F., da Costa, Luis Guilherme V., Takaoka, Flavio, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Serpa Neto, Ary, Barbosa, R.P., Canet, J., Cata, J.P., Cesar, D.S., Chaves, R.C.F., D’Orto, U.C., Da Costa, L.G.V., De Baerdemaeker, L., Galdi, J.R., Gama de Abreu, M., Gottumukkala, V., Hemmes, S.N.T., Hollmann, M.W., Kalmar, A.F., Mariano, R., Matot, I., Mazzinari, G., Mills, G.H., Pelosi, P., Posso, I.P., Queiroz, V.N.F., Schultz, M.J., Serpa Neto, A., Sprung, J., Takaoka, F., Teruya, A., Vidal Melo, M.F., Agarwala, Aalok V., Akeroyd, Louise, Andorlini, Francesco, Anicetti, Lisa, Antonelli, Massimo, Arantes, Bruno S., Ariño Irujo, Jose J., Artsi, Hanna, Babian, Renata, Barbosa, Rogerio P., Barker, Doug, Basagni, Diletta, Basso, Nicola, Beltran, Joan, Bocciero, Vittorio, Bonatti, Giulia, Boriati, Ernesto, Bravo, Mauro, Brazzi, Luca, Brearton, Chris, Brennan, Andrew, Bulinski, Adam M., Cafagna, Sara, Cardoni, Andrea, Castelló Mora, Paula, Cata, Juan P., Cesar, Daniel S., Chaves, Renato CF., Chen, Lee-Lynn, Chukkambotla, Srikanth, Ciccozzi, Alessandra, Cilia, Danae, Cope, Sean, D’Orto, Ulisses C., Da Costa, Luis Guilherme V., Dalton, Claire, Davi, Alessandra, De Bonis, Marina del Barrio, De Gaudio, Angelo Raffaele, De Luca, Lucilla, Delgado, Carlos C., Deljou, Atousa, Di Ruscio, Cecilia, Droger, Sijgje M., Duberley, Stephen, Eidelman, Leonid A., Evans, Alison, Fabiani, Constanza, Fasciano, Umberto, Firth-Gieben, Jennifer, Fitchett, Jillian, Fundarò, Angela, Galdi, Jose Roberto, Gallo, Verdiana, Gavagni, Mattia, Gottumukkala, Vijaya, Graham, Chris, Granell Gil, Manuel, Gratarola, Angelo, Grillandini, Chiara, Groeben, Harald-Thomas, Ismail, Nesrine, Jacob, Reni, Jones, Chris, Jones, Rebecca, Kalmar, Alain F., Kapoor, Ritoo, Kelliher, Leigh, Köhne, Wiebke, Koopman, Joseph SHA., Lanka, Prasad, Lee, Jae-Woo, Liban, Bernard, Livi, Francesca, Mariano, Renato, Martinez Plumed, Ruth, Matot, Idit, Mazzella, Marta, McClure, Stewart, McMonagle, Martina, Mills, Gary H., Mirabella, Lucia, Monsalve, Concepción, Moon, Angela, Morchio, Laura, Morris, Frances, Motroni, Lorenzo, Mura, Benedetta, Nerini, Alessandro, Noumedem Sonna, Elodia C., Oakes, Neil, Orlandi, Marina, Paladini, Antonella, Patil, Anita, Patil, Vishal, Patrone, Valentina, Pinder, Angela, Piroli, Alba, Posso, Irimar P., Queiroz, Veronica NF., Rabbu, Yosef S., Rabenalt, Robert, Romagnoli, Stefano, Ronen, Ariel, Rothman, Felipe, Rusagara, Patrick, Russo, Andrea, Sabov, Moldovan, Saitta, Thomas, Shah, Nirav, Smith, Neil, Sollazzi, Liliana, Sprung, Juraj, Stewart, Emma, Stones, Elizabeth, Storton, Kim, Tena, Beatriz, Terreni, Eleonora, Teruya, Alexandre, Travaglia, Chiara, Treschan, Tanja A., Vanoverschelde, Henk, Venkatesh, Harish, Vidal Melo, Marcos F., Villa, Gianluca, Vossen, Robbert, Webber, Stephen, Weingarten, Toby N., Willcocks, Matt, Winslow, Luke, and Woods, Lindsey
- Published
- 2021
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3. Factores de riesgo para PPC en cirugía abdominal laparoscópica no robótica frente a la laparoscópica robótica (LapRas): Razonamiento y protocolo mediante un análisis a nivel de paciente de LAS VEGAS y AVATaR
- Author
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Serafini, S.C., primary, Hemmes, S.N.T., additional, Serpa Neto, A., additional, Schultz, M.J., additional, Tschernko, E., additional, Gama de Abreu, M., additional, Mazzinari, G., additional, and Ball, L., additional
- Published
- 2024
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4. Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery – Protocol and statistical analysis plan for an individual patient data meta–analysis of PROVHILO, iPROVE and PROBESE
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Campos, N.S., Bluth, T., Hemmes, S.N.T., Librero, J., Pozo, N., Ferrando, C., Ball, L., Mazzinari, G., Pelosi, P., Gama de Abreu, M., Schultz, M.J., and Serpa Neto, A.
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- 2020
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5. Reevaluación de los efectos de PEEP alta con maniobras de reclutamiento vs. PEEP baja sin maniobras de reclutamiento durante la anestesia general para cirugía: protocolo y plan de análisis estadístico para un metaanálisis de los datos de pacientes individuales de PROVHILO, iPROVE y PROBESE
- Author
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Campos, N.S., Bluth, T., Hemmes, S.N.T., Librero, J., Pozo, N., Ferrando, C., Ball, L., Mazzinari, G., Pelosi, P., Gama de Abreu, M., Schultz, M.J., and Neto, A.S.
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- 2020
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6. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications
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Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Hiesmayr, M., Schmid, W., Urbanek, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., Mossevelde, V., van Malderen, M.C., Dylst, D., Melkebeek, J.V., Beran, M., Hert, S.D., Baerdemaeker, L.D., Heyse, B., Limmen, J.V., Wyffels, P., Jacobs, T., Roels, N., Bruyne, A.D., Velde, S.V.D., Marina, J.Z., Dejana, D.O., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Darija, A.V., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Saric, J.P., Erceg, G., Dvorscak, M.B., Branka, M.S., Pavicic, A.M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Inga, M.B., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., Kafrawy, S.E., Abdelwahab, H.H., Metwally, T., Ahmed, A.R., Ahmed Mostafa, E.S., Hasan, W.F., Ahmed, A.G., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Jaber, S., Prades, A., Krassler, J., Merzky, S., Abreu, M.G.D., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Gueldner, A., Spieth, P., Scharffenberg, M., Thiem, D.T., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Wrigge, H., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M.K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C.V., Campanile, A., Marrella, A., Grasso, S., Michele, M.D., Bona, F., Giacoletto, G., Sardo, E., Sottosanti, L.G.V., Solca, M., Volta, C.A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., Bella, D.L., Mirabella, L., D'antini, D., Pelosi, P., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Parma, A.L.D., Tarzia, V., Dossi, R., Sassone, M.E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S.M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Severgnini, P., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Agreta, G.G., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. Joseph, Hemmes, S., Schultz, M., Hollmann, M., Wiersma, I., Binnekade, J., Bos, L., Boer, C., Duvekot, A., Veld, B.I ‘t, Werger, A., Dennesen, P., Severijns, C., Jong, J.D., Hering, J., Beek, R.V., Ivars, S., Jammer, I.B., Breidablik, A., Hodt, K.S., Fjellanger, F., Avalos, M.V., Jannicke, M.O., Andersson, E., Amir, S.K., Molina, R., Wutai, S., Morais, E., Tareco, G., Ferreira, D., Amaral, J., Castro, M.D.L.G., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I.M., Mirea, L., Grintescu, I.C., Corneci, D., Negoita, S., Dutu, M., Popescu Garotescu, I., Filipescu, D., Prodan, A.B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A.M., Tudoroiu, M.I., Moise, A., Guran, C.T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S.M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, S.G., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Barbka, N.S., Ana, P.G., Jovanov, M., Strazisar, B., Jasmina, M.B., Vesna, N.J., Voje, M., Grynyuk, A., Kostadinov, I., Alenka, S.V., Moral, V., Unzueta, M.C., Puigbo, C., Fava, J., Canet, J., Moret, E., Nunez, M.R., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Hidalgo, F., Yepes, M.J., Martinez-Simon, A., Abajo, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Vivo, J.T., Ruiz, C.S., Andrés Ibañez, J.A.D., Pastor, E., Soro, M., Ferrando, C., Defez, M., Cesar Aldecoa, A.S., Perez, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Bengisun, Z.K., Kazbek, B.K., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N.M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ozgen, S.U., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F.N., Sanlikarip, C., Karaman, F.M., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Ben, C.B., Watt, P., Raymode, P., Pearse, R., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Mills, G., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Ana, F.B., Luzier, E., Almagro, A., Melo, M.V., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Gregoretti, C., Neto, A.S., Hemmes, S.N.T., Ball, L., Hollmann, M.W., Mills, G.H., Melo, M.F.V., Putensen, C., Gama de Abreu, M., and Schultz, M.J.
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- 2019
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7. Intraoperative ventilation settings and their associations with postoperative pulmonary complications in obese patients
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Ball, L., Hemmes, S.N.T., Serpa Neto, A., Bluth, T., Canet, J., Hiesmayr, M., Hollmann, M.W., Mills, G.H., Vidal Melo, M.F., Putensen, C., Schmid, W., Severgnini, P., Wrigge, H., Gama de Abreu, M., Schultz, M.J., and Pelosi, P.
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- 2018
- Full Text
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8. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications
- Author
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Cortegiani, A., primary, Gregoretti, C., additional, Neto, A.S., additional, Hemmes, S.N.T., additional, Ball, L., additional, Canet, J., additional, Hiesmayr, M., additional, Hollmann, M.W., additional, Mills, G.H., additional, Melo, M.F.V., additional, Putensen, C., additional, Schmid, W., additional, Severgnini, P., additional, Wrigge, H., additional, Gama de Abreu, M., additional, Schultz, M.J., additional, Pelosi, P., additional, Kroell, W., additional, Metzler, H., additional, Struber, G., additional, Wegscheider, T., additional, Gombotz, H., additional, Urbanek, B., additional, Kahn, D., additional, Momeni, M., additional, Pospiech, A., additional, Lois, F., additional, Forget, P., additional, Grosu, I., additional, Poelaert, J., additional, Mossevelde, V., additional, van Malderen, M.C., additional, Dylst, D., additional, Melkebeek, J.V., additional, Beran, M., additional, Hert, S.D., additional, Baerdemaeker, L.D., additional, Heyse, B., additional, Limmen, J.V., additional, Wyffels, P., additional, Jacobs, T., additional, Roels, N., additional, Bruyne, A.D., additional, Velde, S.V.D., additional, Marina, J.Z., additional, Dejana, D.O., additional, Pernar, S., additional, Zunic, J., additional, Miskovic, P., additional, Zilic, A., additional, Kvolik, S., additional, Ivic, D., additional, Darija, A.V., additional, Skiljic, S., additional, Vinkovic, H., additional, Oputric, I., additional, Juricic, K., additional, Frkovic, V., additional, Kopic, J., additional, Mirkovic, I., additional, Saric, J.P., additional, Erceg, G., additional, Dvorscak, M.B., additional, Branka, M.S., additional, Pavicic, A.M., additional, Goranovic, T., additional, Maldini, B., additional, Radocaj, T., additional, Gavranovic, Z., additional, Inga, M.B., additional, Sehovic, M., additional, Stourac, P., additional, Harazim, H., additional, Smekalova, O., additional, Kosinova, M., additional, Kolacek, T., additional, Hudacek, K., additional, Drab, M., additional, Brujevic, J., additional, Vitkova, K., additional, Jirmanova, K., additional, Volfova, I., additional, Dzurnakova, P., additional, Liskova, K., additional, Dudas, R., additional, Filipsky, R., additional, Kafrawy, S.E., additional, Abdelwahab, H.H., additional, Metwally, T., additional, Ahmed, A.R., additional, Ahmed Mostafa, E.S., additional, Hasan, W.F., additional, Ahmed, A.G., additional, Yassin, H., additional, Magdy, M., additional, Abdelhady, M., additional, Mahran, M., additional, Herodes, E., additional, Kivik, P., additional, Oganjan, J., additional, Aun, A., additional, Sormus, A., additional, Sarapuu, K., additional, Mall, M., additional, Karjagin, J., additional, Futier, E., additional, Petit, A., additional, Gerard, A., additional, Marret, E., additional, Solier, M., additional, Jaber, S., additional, Prades, A., additional, Krassler, J., additional, Merzky, S., additional, Abreu, M.G.D., additional, Uhlig, C., additional, Kiss, T., additional, Bundy, A., additional, Bluth, T., additional, Gueldner, A., additional, Spieth, P., additional, Scharffenberg, M., additional, Thiem, D.T., additional, Koch, T., additional, Treschan, T., additional, Schaefer, M., additional, Bastin, B., additional, Geib, J., additional, Weiss, M., additional, Kienbaum, P., additional, Pannen, B., additional, Gottschalk, A., additional, Konrad, M., additional, Westerheide, D., additional, Schwerdtfeger, B., additional, Simon, P., additional, Reske, A., additional, Nestler, C., additional, Valsamidis, D., additional, Stroumpoulis, K., additional, Antholopoulos, G., additional, Andreou, A., additional, Karapanos, D., additional, Theodoraki, K., additional, Gkiokas, G., additional, Tasoulis, M.K., additional, Sidiropoulou, T., additional, Zafeiropoulou, F., additional, Florou, P., additional, Pandazi, A., additional, Tsaousi, G., additional, Nouris, C., additional, Pourzitaki, C., additional, Bystritski, D., additional, Pizov, R., additional, Eden, A., additional, Pesce, C.V., additional, Campanile, A., additional, Marrella, A., additional, Grasso, S., additional, Michele, M.D., additional, Bona, F., additional, Giacoletto, G., additional, Sardo, E., additional, Sottosanti, L.G.V., additional, Solca, M., additional, Volta, C.A., additional, Spadaro, S., additional, Verri, M., additional, Ragazzi, R., additional, Zoppellari, R., additional, Cinnella, G., additional, Raimondo, P., additional, Bella, D.L., additional, Mirabella, L., additional, D'antini, D., additional, Molin, A., additional, Brunetti, I., additional, Gratarola, A., additional, Pellerano, G., additional, Sileo, R., additional, Pezzatto, S., additional, Montagnani, L., additional, Pasin, L., additional, Landoni, G., additional, Zangrillo, A., additional, Beretta, L., additional, Parma, A.L.D., additional, Tarzia, V., additional, Dossi, R., additional, Sassone, M.E., additional, Sances, D., additional, Tredici, S., additional, Spano, G., additional, Castellani, G., additional, Delunas, L., additional, Peradze, S., additional, Venturino, M., additional, Arpino, I., additional, Sher, S., additional, Tommasino, C., additional, Rapido, F., additional, Morelli, P., additional, Vargas, M., additional, Servillo, G., additional, Cortegiani, A., additional, Raineri, S.M., additional, Montalto, F., additional, Russotto, V., additional, Giarratano, A., additional, Baciarello, M., additional, Generali, M., additional, Cerati, G., additional, Leykin, Y., additional, Bressan, F., additional, Bartolini, V., additional, Zamidei, L., additional, Brazzi, L., additional, Liperi, C., additional, Sales, G., additional, Pistidda, L., additional, Brugnoni, E., additional, Musella, G., additional, Bacuzzi, A., additional, Muhardri, D., additional, Agreta, G.G., additional, Sada, F., additional, Bytyqi, A., additional, Karbonskiene, A., additional, Aukstakalniene, R., additional, Teberaite, Z., additional, Salciute, E., additional, Tikuisis, R., additional, Miliauskas, P., additional, Jurate, S., additional, Kontrimaviciute, E., additional, Tomkute, G., additional, Xuereb, J., additional, Bezzina, M., additional, Borg, F. Joseph, additional, Hemmes, S., additional, Schultz, M., additional, Hollmann, M., additional, Wiersma, I., additional, Binnekade, J., additional, Bos, L., additional, Boer, C., additional, Duvekot, A., additional, Veld, B.I ‘t, additional, Werger, A., additional, Dennesen, P., additional, Severijns, C., additional, Jong, J.D., additional, Hering, J., additional, Beek, R.V., additional, Ivars, S., additional, Jammer, I.B., additional, Breidablik, A., additional, Hodt, K.S., additional, Fjellanger, F., additional, Avalos, M.V., additional, Jannicke, M.O., additional, Andersson, E., additional, Amir, S.K., additional, Molina, R., additional, Wutai, S., additional, Morais, E., additional, Tareco, G., additional, Ferreira, D., additional, Amaral, J., additional, Castro, M.D.L.G., additional, Cadilha, S., additional, Appleton, S., additional, Parente, S., additional, Correia, M., additional, Martins, D., additional, Monteirosa, A., additional, Ricardo, A., additional, Rodrigues, S., additional, Horhota, L., additional, Grintescu, I.M., additional, Mirea, L., additional, Grintescu, I.C., additional, Corneci, D., additional, Negoita, S., additional, Dutu, M., additional, Popescu Garotescu, I., additional, Filipescu, D., additional, Prodan, A.B., additional, Droc, G., additional, Fota, R., additional, Popescu, M., additional, Tomescu, D., additional, Petcu, A.M., additional, Tudoroiu, M.I., additional, Moise, A., additional, Guran, C.T., additional, Gherghina, I., additional, Costea, D., additional, Cindea, I., additional, Copotoiu, S.M., additional, Copotoiu, R., additional, Barsan, V., additional, Tolcser, Z., additional, Riciu, M., additional, Moldovan, S.G., additional, Veres, M., additional, Gritsan, A., additional, Kapkan, T., additional, Gritsan, G., additional, Korolkov, O., additional, Kulikov, A., additional, Lubnin, A., additional, Ovezov, A., additional, Prokoshev, P., additional, Lugovoy, A., additional, Anipchenko, N., additional, Babayants, A., additional, Komissarova, I., additional, Zalina, K., additional, Likhvantsev, V., additional, Fedorov, S., additional, Lazukic, A., additional, Pejakovic, J., additional, Mihajlovic, D., additional, Kusnierikova, Z., additional, Zelinkova, M., additional, Bruncakova, K., additional, Polakovicova, L., additional, Sobona, V., additional, Barbka, N.S., additional, Ana, P.G., additional, Jovanov, M., additional, Strazisar, B., additional, Jasmina, M.B., additional, Vesna, N.J., additional, Voje, M., additional, Grynyuk, A., additional, Kostadinov, I., additional, Alenka, S.V., additional, Moral, V., additional, Unzueta, M.C., additional, Puigbo, C., additional, Fava, J., additional, Moret, E., additional, Nunez, M.R., additional, Sendra, M., additional, Brunelli, A., additional, Rodenas, F., additional, Monedero, P., additional, Hidalgo, F., additional, Yepes, M.J., additional, Martinez-Simon, A., additional, Abajo, A., additional, Lisi, A., additional, Perez, G., additional, Martinez, R., additional, Granell, M., additional, Vivo, J.T., additional, Ruiz, C.S., additional, Andrés Ibañez, J.A.D., additional, Pastor, E., additional, Soro, M., additional, Ferrando, C., additional, Defez, M., additional, Cesar Aldecoa, A.S., additional, Perez, R., additional, Rico, J., additional, Jawad, M., additional, Saeed, Y., additional, Gillberg, L., additional, Bengisun, Z.K., additional, Kazbek, B.K., additional, Coskunfirat, N., additional, Boztug, N., additional, Sanli, S., additional, Yilmaz, M., additional, Hadimioglu, N., additional, Senturk, N.M., additional, Camci, E., additional, Kucukgoncu, S., additional, Sungur, Z., additional, Sivrikoz, N., additional, Ozgen, S.U., additional, Toraman, F., additional, Selvi, O., additional, Senturk, O., additional, Yildiz, M., additional, Kuvaki, B., additional, Gunenc, F., additional, Kucukguclu, S., additional, Ozbilgin, S., additional, Maral, J., additional, Canli, S., additional, Arun, O., additional, Saltali, A., additional, Aydogan, E., additional, Akgun, F.N., additional, Sanlikarip, C., additional, Karaman, F.M., additional, Mazur, A., additional, Vorotyntsev, S., additional, Rousseau, G., additional, Barrett, C., additional, Stancombe, L., additional, Shelley, B., additional, Scholes, H., additional, Limb, J., additional, Rafi, A., additional, Wayman, L., additional, Deane, J., additional, Rogerson, D., additional, Williams, J., additional, Yates, S., additional, Rogers, E., additional, Pulletz, M., additional, Moreton, S., additional, Jones, S., additional, Venkatesh, S., additional, Burton, M., additional, Brown, L., additional, Goodall, C., additional, Rucklidge, M., additional, Fuller, D., additional, Nadolski, M., additional, Kusre, S., additional, Lundberg, M., additional, Everett, L., additional, Nutt, H., additional, Zuleika, M., additional, Carvalho, P., additional, Clements, D., additional, Ben, C.B., additional, Watt, P., additional, Raymode, P., additional, Pearse, R., additional, Mohr, O., additional, Raj, A., additional, Creary, T., additional, Chishti, A., additional, Bell, A., additional, Higham, C., additional, Cain, A., additional, Gibb, S., additional, Mowat, S., additional, Franklin, D., additional, West, C., additional, Minto, G., additional, Boyd, N., additional, Mills, G., additional, Calton, E., additional, Walker, R., additional, Mackenzie, F., additional, Ellison, B., additional, Roberts, H., additional, Chikungwa, M., additional, Jackson, C., additional, Donovan, A., additional, Foot, J., additional, Homan, E., additional, Montgomery, J., additional, Portch, D., additional, Mercer, P., additional, Palmer, J., additional, Paddle, J., additional, Fouracres, A., additional, Datson, A., additional, Andrew, A., additional, Welch, L., additional, Rose, A., additional, Varma, S., additional, Simeson, K., additional, Rambhatla, M., additional, Susarla, J., additional, Marri, S., additional, Kodaganallur, K., additional, Das, A., additional, Algarsamy, S., additional, Colley, J., additional, Davies, S., additional, Szewczyk, M., additional, Smith, T., additional, Ana, F.B., additional, Luzier, E., additional, Almagro, A., additional, Melo, M.V., additional, Fernando, L., additional, Sulemanji, D., additional, Sprung, J., additional, Weingarten, T., additional, Kor, D., additional, Scavonetto, F., additional, and Tze, Y., additional
- Published
- 2019
- Full Text
- View/download PDF
9. Lung-protective perioperative mechanical ventilation
- Author
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Hemmes, S.N.T., Schultz, M.J., Hollmann, M.W., and Faculteit der Geneeskunde
- Subjects
respiratory system ,circulatory and respiratory physiology ,respiratory tract diseases - Abstract
Intraoperative ventilation has the potential to cause lung injury and possibly increase risk of pulmonary complications after surgery. Use of large tidal volumes could cause overdistension of lung tissue, which can be aggravated by too high levels of positive end-expiratory pressure (PEEP). Too low levels of PEEP, though, could result in repetitive opening and closing of lung tissue. The main aim of this thesis was to investigate the effect of intraoperative use of higher levels of PEEP and recruitment manoeuvres on occurrence of postoperative pulmonary complications (PPCs). We hypothesized that this strategy would protect against development of PPCs during low tidal volume ventilation. We further investigated several other aspects of perioperative ventilation, focussing on associations between ventilator settings and PPCs and outcome. The main finding is that ventilation with higher levels of PEEP does not seem to reduce development of PPCs during low tidal volume ventilation in non-obese patients undergoing major surgery. High levels of PEEP may even be detrimental by causing hemodynamic compromise and maybe even by increasing the risk of PPCs. We further show that lung-protective strategies using low tidal volumes combined with higher levels of PEEP reduce the incidence of PPCs, but do not shorten hospital length of stay, or improve survival. In the event of pulmonary complications, patients do have longer lengths of stay and higher incidence of mortality. Finally, use of higher levels of PEEP during postoperative ventilation after cardiac surgery resulted in better compliance and oxygenation, but this was not sustained after extubation.
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- 2015
10. Prolonged Mechanical Ventilation Aggravates Ventilator-Induced Lung Injury
- Author
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Hegeman, M.A., primary, Hemmes, S.N.T., additional, Kuipers, M.T., additional, Bos, Lieuwe D.J., additional, Jongsma, G., additional, van der Sluijs, K.F., additional, and Schultz, M.J., additional
- Published
- 2012
- Full Text
- View/download PDF
11. The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study
- Author
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Mazzinari, G., Serpa Neto, A., Hemmes, S. N. T., Hedenstierna, G., Jaber, S., Hiesmayr, M., Hollmann, M. W., Mills, G. H., Vidal Melo, M. F., Pearse, R. M., Putensen, C., Schmid, W., Severgnini, P., Wrigge, H., Cambronero, O. D., Ball, L., de Abreu, M. G., Pelosi, P., Schultz, M. J., Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Urbanek, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., van Mossevelde, V., van Malderen, M. -C., Dylst, D., van Melkebeek, J., Beran, M., de Hert, S., De Baerdemaeker, L., Heyse, B., Van Limmen, J., Wyffels, P., Jacobs, T., Roels, N., De Bruyne, A., van de Velde, S., Leva, B., Damster, S., Plichon, B., Juros-Zovko, M., Djonovic-Omanovic, D., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Azenic-Venzera, D., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Karanovic, N., Carev, M., Dropulic, N., Saric, J. P., Erceg, G., Dvorscak, M. B., Mazul-Sunko, B., Pavicic, A. M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Mladic-Batinica, I., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., el Kafrawy, S., Abdelwahab, H. H., Metwally, T., Abdel-Razek, A., El-Shaarawy, A. M., Hasan, W. F., Ahmed, A. G., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Prades, A., Krassler, J., Merzky, S., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Gueldner, A., Spieth, P., Scharffenberg, M., Thiem, D. T., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M. -K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C. V., Campanile, A., Marrella, A., Grasso, S., De Michele, M., Bona, F., Giacoletto, G., Sardo, E., Giancarlo, L., Sottosanti, V., Solca, M., Volta, C. A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., La Bella, D., Mirabella, L., D'Antini, D., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Di Parma, A. L., Tarzia, V., Dossi, R., Sassone, M. E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S. M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Gecaj-Gashi, A., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. J., Hemmes, S., Schultz, M., Hollmann, M., Wiersma, I., Binnekade, J., Bos, L., Boer, C., Duvekot, A., in 't Veld, B., Werger, A., Dennesen, P., Severijns, C., De Jong, J., Hering, J., van Beek, R., Ivars, S., Jammer, I., Breidablik, A., Hodt, K. S., Fjellanger, F., Avalos, M. V., Mellin-Olsen, J., Andersson, E., Shafi-Kabiri, A., Molina, R., Wutai, S., Morais, E., Tareco, G., Ferreira, D., Amaral, J., de Lurdes Goncalves Castro, M., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I. M., Mirea, L., Grintescu, I. C., Corneci, D., Negoita, S., Dutu, M., Garotescu, I. P., Filipescu, D., Prodan, A. B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A. M., Tudoroiu, M. I., Moise, A., Guran, C. -T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S. -M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, S. G., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Novak-Supe, B., Pekle-Golez, A., Jovanov, M., Strazisar, B., Markovic-Bozic, J., Novak-Jankovic, V., Voje, M., Grynyuk, A., Kostadinov, I., Spindler-Vesel, A., Moral, V., Unzueta, M. C., Puigbo, C., Fava, J., Canet, J., Moret, E., Rodriguez Nunez, M., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Martinez, F. H., Temino, M. J. Y., Martinez Simon, A., de Abajo Larriba, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Vivo, J. T., Ruiz, C. S., de Andres Ibanez, J. A., Pastor, E., Soro, M., Ferrando, C., Defez, M., Alvares-Santullano, C. A., Perez, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Bengisun, Z. K., Kazbek, B. K., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N. M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ozgen, S. U., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F. N., Sanlikarip, C., Karaman, F. M., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Creagh-Brown, B., Watt, P., Raymode, P., Pearse, R., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Mills, G., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Fernandez-Bustamante, A., Luzier, E., Almagro, A., Melo, M. V., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Mazzinari G., Serpa Neto A., Hemmes S.N.T., Hedenstierna G., Jaber S., Hiesmayr M., Hollmann M.W., Mills G.H., Vidal Melo M.F., Pearse R.M., Putensen C., Schmid W., Severgnini P., Wrigge H., Cambronero O.D., Ball L., de Abreu M.G., Pelosi P., Schultz M.J., Kroell W., Metzler H., Struber G., Wegscheider T., Gombotz H., Urbanek B., Kahn D., Momeni M., Pospiech A., Lois F., Forget P., Grosu I., Poelaert J., van Mossevelde V., van Malderen M.-C., Dylst D., van Melkebeek J., Beran M., de Hert S., De Baerdemaeker L., Heyse B., Van Limmen J., Wyffels P., Jacobs T., Roels N., De Bruyne A., van de Velde S., Leva B., Damster S., Plichon B., Juros-Zovko M., Djonovic-Omanovic D., Pernar S., Zunic J., Miskovic P., Zilic A., Kvolik S., Ivic D., Azenic-Venzera D., Skiljic S., Vinkovic H., Oputric I., Juricic K., Frkovic V., Kopic J., Mirkovic I., Karanovic N., Carev M., Dropulic N., Saric J.P., Erceg G., Dvorscak M.B., Mazul-Sunko B., Pavicic A.M., Goranovic T., Maldini B., Radocaj T., Gavranovic Z., Mladic-Batinica I., Sehovic M., Stourac P., Harazim H., Smekalova O., Kosinova M., Kolacek T., Hudacek K., Drab M., Brujevic J., Vitkova K., Jirmanova K., Volfova I., Dzurnakova P., Liskova K., Dudas R., Filipsky R., el Kafrawy S., Abdelwahab H.H., Metwally T., Abdel-Razek A., El-Shaarawy A.M., Hasan W.F., Ahmed A.G., Yassin H., Magdy M., Abdelhady M., Mahran M., Herodes E., Kivik P., Oganjan J., Aun A., Sormus A., Sarapuu K., Mall M., Karjagin J., Futier E., Petit A., Gerard A., Marret E., Solier M., Prades A., Krassler J., Merzky S., Uhlig C., Kiss T., Bundy A., Bluth T., Gueldner A., Spieth P., Scharffenberg M., Thiem D.T., Koch T., Treschan T., Schaefer M., Bastin B., Geib J., Weiss M., Kienbaum P., Pannen B., Gottschalk A., Konrad M., Westerheide D., Schwerdtfeger B., Simon P., Reske A., Nestler C., Valsamidis D., Stroumpoulis K., Antholopoulos G., Andreou A., Karapanos D., Theodoraki K., Gkiokas G., Tasoulis M.-K., Sidiropoulou T., Zafeiropoulou F., Florou P., Pandazi A., Tsaousi G., Nouris C., Pourzitaki C., Bystritski D., Pizov R., Eden A., Pesce C.V., Campanile A., Marrella A., Grasso S., De Michele M., Bona F., Giacoletto G., Sardo E., Giancarlo L., Sottosanti V., Solca M., Volta C.A., Spadaro S., Verri M., Ragazzi R., Zoppellari R., Cinnella G., Raimondo P., La Bella D., Mirabella L., D'antini D., Molin A., Brunetti I., Gratarola A., Pellerano G., Sileo R., Pezzatto S., Montagnani L., Pasin L., Landoni G., Zangrillo A., Beretta L., Di Parma A.L., Tarzia V., Dossi R., Sassone M.E., Sances D., Tredici S., Spano G., Castellani G., Delunas L., Peradze S., Venturino M., Arpino I., Sher S., Tommasino C., Rapido F., Morelli P., Vargas M., Servillo G., Cortegiani A., Raineri S.M., Montalto F., Russotto V., Giarratano A., Baciarello M., Generali M., Cerati G., Leykin Y., Bressan F., Bartolini V., Zamidei L., Brazzi L., Liperi C., Sales G., Pistidda L., Brugnoni E., Musella G., Bacuzzi A., Muhardri D., Gecaj-Gashi A., Sada F., Bytyqi A., Karbonskiene A., Aukstakalniene R., Teberaite Z., Salciute E., Tikuisis R., Miliauskas P., Jurate S., Kontrimaviciute E., Tomkute G., Xuereb J., Bezzina M., Borg F.J., Hemmes S., Hollmann M., Wiersma I., Binnekade J., Bos L., Boer C., Duvekot A., in 't Veld B., Werger A., Dennesen P., Severijns C., De Jong J., Hering J., van Beek R., Ivars S., Jammer I., Breidablik A., Hodt K.S., Fjellanger F., Avalos M.V., Mellin-Olsen J., Andersson E., Shafi-Kabiri A., Molina R., Wutai S., Morais E., Tareco G., Ferreira D., Amaral J., de Lurdes Goncalves Castro M., Cadilha S., Appleton S., Parente S., Correia M., Martins D., Monteirosa A., Ricardo A., Rodrigues S., Horhota L., Grintescu I.M., Mirea L., Grintescu I.C., Corneci D., Negoita S., Dutu M., Garotescu I.P., Filipescu D., Prodan A.B., Droc G., Fota R., Popescu M., Tomescu D., Petcu A.M., Tudoroiu M.I., Moise A., Guran C.-T., Gherghina I., Costea D., Cindea I., Copotoiu S.-M., Copotoiu R., Barsan V., Tolcser Z., Riciu M., Moldovan S.G., Veres M., Gritsan A., Kapkan T., Gritsan G., Korolkov O., Kulikov A., Lubnin A., Ovezov A., Prokoshev P., Lugovoy A., Anipchenko N., Babayants A., Komissarova I., Zalina K., Likhvantsev V., Fedorov S., Lazukic A., Pejakovic J., Mihajlovic D., Kusnierikova Z., Zelinkova M., Bruncakova K., Polakovicova L., Sobona V., Novak-Supe B., Pekle-Golez A., Jovanov M., Strazisar B., Markovic-Bozic J., Novak-Jankovic V., Voje M., Grynyuk A., Kostadinov I., Spindler-Vesel A., Moral V., Unzueta M.C., Puigbo C., Fava J., Canet J., Moret E., Rodriguez Nunez M., Sendra M., Brunelli A., Rodenas F., Monedero P., Martinez F.H., Temino M.J.Y., Martinez Simon A., de Abajo Larriba A., Lisi A., Perez G., Martinez R., Granell M., Vivo J.T., Ruiz C.S., de Andres Ibanez J.A., Pastor E., Soro M., Ferrando C., Defez M., Alvares-Santullano C.A., Perez R., Rico J., Jawad M., Saeed Y., Gillberg L., Bengisun Z.K., Kazbek B.K., Coskunfirat N., Boztug N., Sanli S., Yilmaz M., Hadimioglu N., Senturk N.M., Camci E., Kucukgoncu S., Sungur Z., Sivrikoz N., Ozgen S.U., Toraman F., Selvi O., Senturk O., Yildiz M., Kuvaki B., Gunenc F., Kucukguclu S., Ozbilgin S., Maral J., Canli S., Arun O., Saltali A., Aydogan E., Akgun F.N., Sanlikarip C., Karaman F.M., Mazur A., Vorotyntsev S., Rousseau G., Barrett C., Stancombe L., Shelley B., Scholes H., Limb J., Rafi A., Wayman L., Deane J., Rogerson D., Williams J., Yates S., Rogers E., Pulletz M., Moreton S., Jones S., Venkatesh S., Burton M., Brown L., Goodall C., Rucklidge M., Fuller D., Nadolski M., Kusre S., Lundberg M., Everett L., Nutt H., Zuleika M., Carvalho P., Clements D., Creagh-Brown B., Watt P., Raymode P., Pearse R., Mohr O., Raj A., Creary T., Chishti A., Bell A., Higham C., Cain A., Gibb S., Mowat S., Franklin D., West C., Minto G., Boyd N., Mills G., Calton E., Walker R., Mackenzie F., Ellison B., Roberts H., Chikungwa M., Jackson C., Donovan A., Foot J., Homan E., Montgomery J., Portch D., Mercer P., Palmer J., Paddle J., Fouracres A., Datson A., Andrew A., Welch L., Rose A., Varma S., Simeson K., Rambhatla M., Susarla J., Marri S., Kodaganallur K., Das A., Algarsamy S., Colley J., Davies S., Szewczyk M., Smith T., Fernandez-Bustamante A., Luzier E., Almagro A., Melo M.V., Fernando L., Sulemanji D., Sprung J., Weingarten T., Kor D., Scavonetto F., Tze Y., Anesthesiology research group, Supporting clinical sciences, Anesthesiology, Guido, Mazzinari, Ary Serpa, Neto, Sabrine N, T Hemme, Goran, Hedenstierna, Samir, Jaber, Michael, Hiesmayr, Markus, W Hollmann, Gary, H Mill, Marcos, F Vidal Melo, Rupert, M Pearse, Christian, Putensen, Werner, Schmid, Paolo, Severgnini, Hermann, Wrigge, Oscar Diaz, Cambronero, Lorenzo, Ball, Marcelo Gama de, Abreu, Paolo, Pelosi, Marcus, J Schultz (LAS VEGAS study–investigator, PROtective VEntilation, Network, Clinical Trial Network of the European Society of, Anaesthesiology), Zangrillo, A, Landoni, G, Beretta, L, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pulmonary medicine, IOO, ACS - Microcirculation, ACS - Heart failure & arrhythmias, ACS - Diabetes & metabolism, study–investigators, LAS VEGAS, NETwork, PROtective VEntilation, Anaesthesiology, Clinical Trial Network of the European Society of, Mazzinari, Guido, Serpa Neto, Ary, Hemmes, Sabrine N T, Hedenstierna, Goran, Jaber, Samir, Hiesmayr, Michael, Hollmann, Markus W, Mills, Gary H, Vidal Melo, Marcos F, Pearse, Rupert M, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Wrigge, Hermann, Cambronero, Oscar Diaz, Ball, Lorenzo, de Abreu, Marcelo Gama, Pelosi, Paolo, Schultz, Marcus, J, Servillo, G, Vargas, M, Intensive Care Medicine, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, Pulmonology, and APH - Global Health
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Driving pressure ,Laparoscopic surgery ,Laparoscopy ,PEEP ,Perioperative ventilation ,Pneumoperitoneum ,Protective ventilation ,Respiratory mechanics ,Lung Diseases ,Male ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Cohort Studies ,Positive-Pressure Respiration ,Postoperative Complications ,0302 clinical medicine ,030202 anesthesiology ,Abdomen ,Clinical endpoint ,Middle Aged ,3. Good health ,Driving pressure, Laparoscopic surgery, Laparoscopy, PEEP, Perioperative ventilation, Pneumoperitoneum, Protective ventilation, Respiratory mechanics ,Female ,Research Article ,Cohort study ,Adult ,medicine.medical_specialty ,Anestesi och intensivvård ,Anesthesia, General ,NO ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,medicine ,Humans ,Propensity Score ,Adverse effect ,Aged ,Retrospective Studies ,Anesthesiology and Intensive Care ,business.industry ,Kirurgi ,030208 emergency & critical care medicine ,Odds ratio ,medicine.disease ,Respiration, Artificial ,Surgery ,Anesthesiology and Pain Medicine ,lcsh:Anesthesiology ,Relative risk ,business ,Abdominal surgery - Abstract
Background It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. Results The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P P P TW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12– to 1.14], P P P Conclusions ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. Trial registration LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223).
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- 2021
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12. Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) with Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial
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Bluth, T, Neto, As, Schultz, Mj, Pelosi, P, de Abreu MG, Bobek, I, Canet, Jc, de Baerdemaeker, L, Gregoretti, C, Hedenstierna, G, Hemmes, Snt, Hiesmayr, M, Hollmann, M, Jaber, S, Laffey, J, Licker, Mj, Markstaller, K, Matot, I, Mills, G, Mulier, Jp, Putensen, C, Rossaint, R, Schmitt, J, Senturk, M, Severgnini, P, Sprung, J, Melo, Mfv, Wrigge, H, Abelha, F, Abitagaoglu, S, Achilles, M, Adebesin, A, Adriaensens, I, Ahene, C, Akbar, F, Al Harbi, M, al Kallab RA, Albanel, X, Aldenkortt, F, Alfouzan, Ras, Alruqaie, R, Altermatt, F, Araujo, Bld, Arbesu, G, Artsi, H, Aurilio, C, Ayanoglu, Oh, Bacuzzi, A, Baig, H, Baird, Y, Balonov, K, Balust, J, Banks, S, Bao, Xd, Baumgartner, M, Tortosa, Ib, Bergamaschi, A, Bergmann, L, Bigatello, L, Perez, Eb, Birr, K, Bojaxhi, E, Bonenti, C, Bonney, I, Bos, Ee, Bowman, S, Braz, Lg, Brugnoni, E, Brunetti, I, Bruni, A, Buenvenida, Sl, Camerini, Cj, Canet, J, Capatti, B, Carmona, J, Carungcong, J, Carvalho, M, Cattan, A, Cavaleiro, C, Chiumello, D, Ciardo, S, Coburn, M, Colella, U, Contreras, V, Dincer, Pc, Cotter, E, Crovetto, M, Crovetto, W, Darrah, W, Davies, S, De Hert, S, Peces, Ed, Delphin, E, Diaper, J, do Nascimento, P, Donatiello, V, Dong, J, Dourado, Md, Dullenkopf, A, Ebner, F, Elgendy, H, Ellenberger, C, Ari, De, Ermert, T, Farah, F, Fernandez-Bustamante, A, Ferreira, C, Fiore, M, Fonte, A, Palahi, Cf, Galimberti, A, Garofano, N, Giaccari, Lg, Gilsanz, F, Girrbach, F, Gobbi, L, Godfried, Mb, Goettel, N, Goldstein, Pa, Goren, O, Gorlin, A, Gil, Mg, Gratarola, A, Graterol, J, Guyon, P, Haire, K, Harou, P, Helf, A, Hempel, G, Cadiz, Mjh, Heyse, B, Hollmann, Mw, Huercio, I, Ilievska, J, Jakus, L, Jeganath, V, Jelting, Y, Jung, M, Kabon, B, Kacha, A, Ilic, Mk, Karuppiah, A, Kavas, Ad, Barcelos, Gk, Kellogg, Ta, Kemper, J, Kerbrat, R, Khodr, S, Kienbaum, P, Kir, B, Kiss, T, Kivrak, S, Klaric, V, Koch, T, Koksal, C, Kowark, A, Kranke, P, Kuvaki, B, Kuzmanovska, B, Lange, M, de Lemos MF, Lopez-Baamonde, M, Lopez-Hernandez, A, Lopez-Martinez, M, Luise, S, Macgregor, M, Magalhaes, D, Maillard, J, Malerbi, P, Manimekalai, N, Margarson, M, Martin, Dp, Martin, Yn, Martinez-Ocon, J, Martin-Loeches, I, Maseda, E, Mcauliffe, N, Mckenzie, Tj, Medina, P, Meersch, M, Menzen, A, Mertens, E, Meurer, B, Meyer-Treschan, T, Miao, Ch, Micalizzi, C, Milic, M, Modolo, Nsp, Moine, P, Molders, P, Montero-Feijoo, A, Moret, E, Muller, Mk, Murphy, Z, Nalwaya, P, Naumovski, F, Navalesi, P, Lima, Lhne, Adam, Vn, Neumann, C, Newell, C, Nisnevitch, Z, Nizamuddin, J, Novazzi, C, O'Connor, M, Oprea, G, Sungur, Mo, Ozbilgin, S, Pace, Mc, Pacheco, M, Packianathaswamy, B, Gonzalez, Ep, Papaspyros, F, Paredes, S, Passavanti, Mb, Pedemonte, Jc, Peremin, S, Philipsenburg, C, Pinho, D, Pinho, S, Posthuma, Lm, Pota, V, Preckel, B, Priani, P, Rached, Ma, Radoeshki, A, Ragazzi, R, Rajamanickam, T, Rajamohan, A, Ramakrishna, H, Rangarajan, D, Reiterer, C, Renew, Jr, Reynaud, T, Rhys, R, Rivas, E, Robitzky, L, Rubulotta, F, Machado, Hs, Nunes, Cs, Sabbatini, G, Sanahuja, Jm, Sansone, P, Santos, A, Sayedalahl, M, Schaefer, Ms, Scharffenberg, E, Scharffenberg, M, Schiffer, E, Schliewe, N, Schorer, R, Schumann, R, Selmo, G, Sendra, M, Shaw, K, Shosholcheva, M, Sibai, A, Simon, P, Simonassi, F, Sinno, C, Sivrikoz, N, Skandalou, V, Smith, N, Soares, M, Artiles, Ts, Castro, Ds, Sousa, M, Spadaro, S, Stamatakis, E, Steiner, La, Stevenazzi, A, Suarez-de-la-Rica, A, Suppan, M, Teichmann, R, Guerrero, Jmt, Thiel, B, Tolos, R, Altun, Gt, Tucci, M, Turnbull, Za, Turudic, Z, Unterberg, M, Van Limmen, J, Van Nieuwenhove, Y, Van Waesberghe, J, Francisco, M, Melo, V, Vitkovic, B, Vivona, L, Vizcaychipi, M, Volta, Ca, Weber, A, Weingarten, Tn, Wittenstein, J, Wyffels, P, Yague, J, Yates, D, Yavru, A, Zac, L, Zhong, J, Intensive Care Medicine, ACS - Heart failure & arrhythmias, Anesthesiology, ACS - Diabetes & metabolism, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Bluth T., Serpa Neto A., Schultz M.J., Pelosi P., Gama de Abreu M., Bobek I., Canet J.C., Cinella G., de Baerdemaeker L., Gregoretti C., Hedenstierna G., Hemmes S.N.T., Hiesmayr M., Hollmann M.W., Jaber S., Laffey J., Licker M.-J., Markstaller K., Matot I., Mills G.H., Mulier J.P., Putensen C., Rossaint R., Schmitt J., Senturk M., Severgnini P., Sprung J., Vidal Melo M.F., Wrigge H., Abelha F., Abitagaoglu S., Achilles M., Adebesin A., Adriaensens I., Ahene C., Akbar F., Harbi M.A., Al Kallab R.A.K., Albanel X., Aldenkortt F., Alfouzan R.A.S., Alruqaie R., Altermatt F., de Castro Araujo B.L., Arbesu G., Artsi H., Aurilio C., Ayanoglu O.H., Bacuzzi A., Baig H., Baird Y., Balonov K., Balust J., Banks S., Bao X., Baumgartner M., Tortosa I.B., Bergamaschi A., Bergmann L., Bigatello L., Perez E.B., Birr K., Bojaxhi E., Bonenti C., Bonney I., Bos E.M.E., Bowman S., Braz L.G., Brugnoni E., Brull S.J., Brunetti I., Bruni A., Buenvenida S.L., Busch C.J., Camerini G., Capatti B., Carmona J., Carungcong J., Carvalho M., Cattan A., Cavaleiro C., Chiumello D., Ciardo S., Coburn M., Colella U., Contreras V., Dincer P.C., Cotter E., Crovetto M., Darrah W., Davies S., De Hert S., Peces E.D.C., Delphin E., Diaper J., Do Nascimento Junior P., Donatiello V., Dong J., Dourado M.D.S., Dullenkopf A., Ebner F., Elgendy H., Ellenberger C., Erdogan Ari D., Ermert T., Farah F., Fernandez-Bustamante A., Ferreira C., Fiore M., Fonte A., Palahi C.F., Galimberti A., Garofano N., Giaccari L.G., Gilsanz F., Girrbach F., Gobbi L., Godfried M.B., Goettel N., Goldstein P.A., Goren O., Gorlin A., Gil M.G., Gratarola A., Graterol J., Guyon P., Haire K., Harou P., Helf A., Hempel G., Cadiz M.J.H., Heyse B., Huercio I., Ilievska J., Jakus L., Jeganath V., Jelting Y., Jung M., Kabon B., Kacha A., Ilic M.K., Karuppiah A., Kavas A.D., Barcelos G.K., Kellogg T.A., Kemper J., Kerbrat R., Khodr S., Kienbaum P., Kir B., Kiss T., Kivrak S., Klaric V., Koch T., Koksal C., Kowark A., Kranke P., Kuvaki B., Kuzmanovska B., Lange M., de Lemos M.F., Lopez-Baamonde M., Lopez-Hernandez A., Lopez-Martinez M., Luise S., Macgregor M., Magalhaes D., Maillard J., Malerbi P., Manimekalai N., Margarson M., Martin A.K., Martin D.P., Martin Y.N., Martinez-Ocon J., Martin-Loeches I., Maseda E., McAuliffe N., McKenzie T.J., Medina P., Meersch M., Menzen A., Mertens E., Meurer B., Meyer-Treschan T., Miao C., Micalizzi C., Milic M., Modolo N.S.P., Moine P., Molders P., Montero-Feijoo A., Moret E., Muller M.K., Murphy Z., Nalwaya P., Naumovski F., Navalesi P., Navarro E Lima L.H., Adam V.N., Neumann C., Newell C., Nisnevitch Z., Nizamuddin J., Novazzi C., O'connor M., Oprea G., Sungur M.O., Ozbilgin S., Pace M.C., Pacheco M., Packianathaswamy B., Gonzalez E.P., Papaspyros F., Paredes S., Passavanti M.B., Pedemonte J.C., Peremin S., Philipsenburg C., Pinho D., Pinho S., Posthuma L.M., Pota V., Preckel B., Priani P., Rached M.A., Radoeshki A., Ragazzi R., Rajamanickam T., Rajamohan A., Ramakrishna H., Rangarajan D., Reiterer C., Ross Renew J., Reynaud T., Rhys R., Rivas E., Robitzky L., Rubulotta F., Machado H.S., Nunes C.S., Sabbatini G., Samuels J.D., Sanahuja J.M., Sansone P., Santos A., Sayedalahl M., Schaefer M.S., Scharffenberg M., Schiffer E., Schliewe N., Schorer R., Schumann R., Selmo G., Sendra M., Shaw K., Shosholcheva M., Sibai A., Simon P., Simonassi F., Sinno C., Sivrikoz N., Skandalou V., Smith N., Soares M., Artiles T.S., Castro D.S., Sousa M., Spadaro S., Stamatakis E., Steiner L.A., Stevenazzi A., Suarez-De-la-rica A., Suppan M., Teichmann R., Guerrero J.M.T., Thiel B., Tolos R., Altun G.T., Tucci M., Turnbull Z.A., Turudic Z., Unterberg M., Van Limmen J., Van Nieuwenhove Y., Van Waesberghe J., Vitkovic B., Vivona L., Vizcaychipi M., Volta C.A., Weber A., Weingarten T.N., Wittenstein J., Wyffels P., Yague J., Yates D., Yavru A., Zac L., Zhong J., Bluth, T., Serpa Neto, A., Schultz, M. J., Pelosi, P., Gama De Abreu, M., Aurilio, C., Pace, M. C., Passavanti, M. B., Pota, V., and Sansone, P.
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Lung Diseases ,Male ,medicine.medical_treatment ,Atelectasis ,Lung Disease ,01 natural sciences ,Body Mass Index ,Hypoxemia ,Positive-Pressure Respiration ,Postoperative Complications ,0302 clinical medicine ,PEEP, postoperative complications, obese patients ,Anesthesia ,Respiratory function ,030212 general & internal medicine ,Tidal volume ,General Medicine ,Middle Aged ,Pleural Diseases ,respiratory system ,Adult ,Anesthesia, General ,Female ,Humans ,Obesity ,Pulmonary Atelectasis ,Respiratory Insufficiency ,Surgical Procedures, Operative ,Tidal Volume ,Treatment Outcome ,Intraoperative Care ,Operative ,3. Good health ,Pneumothorax ,medicine.symptom ,psychological phenomena and processes ,Human ,circulatory and respiratory physiology ,NO ,03 medical and health sciences ,mental disorders ,medicine ,Pleural Disease ,0101 mathematics ,General ,Positive end-expiratory pressure ,Mechanical ventilation ,Surgical Procedures ,Pulmonary Atelectasi ,business.industry ,010102 general mathematics ,medicine.disease ,respiratory tract diseases ,Respiratory failure ,Postoperative Complication ,business - Abstract
Importance: An intraoperative higher level of positive end-expiratory positive pressure (PEEP) with alveolar recruitment maneuvers improves respiratory function in obese patients undergoing surgery, but the effect on clinical outcomes is uncertain. Objective: To determine whether a higher level of PEEP with alveolar recruitment maneuvers decreases postoperative pulmonary complications in obese patients undergoing surgery compared with a lower level of PEEP. Design, Setting, and Participants: Randomized clinical trial of 2013 adults with body mass indices of 35 or greater and substantial risk for postoperative pulmonary complications who were undergoing noncardiac, nonneurological surgery under general anesthesia. The trial was conducted at 77 sites in 23 countries from July 2014-February 2018; final follow-up: May 2018. Interventions: Patients were randomized to the high level of PEEP group (n = 989), consisting of a PEEP level of 12 cm H2O with alveolar recruitment maneuvers (a stepwise increase of tidal volume and eventually PEEP) or to the low level of PEEP group (n = 987), consisting of a PEEP level of 4 cm H2O. All patients received volume-controlled ventilation with a tidal volume of 7 mL/kg of predicted body weight. Main Outcomes and Measures: The primary outcome was a composite of pulmonary complications within the first 5 postoperative days, including respiratory failure, acute respiratory distress syndrome, bronchospasm, new pulmonary infiltrates, pulmonary infection, aspiration pneumonitis, pleural effusion, atelectasis, cardiopulmonary edema, and pneumothorax. Among the 9 prespecified secondary outcomes, 3 were intraoperative complications, including hypoxemia (oxygen desaturation with Spo2 ≤92% for >1 minute). Results: Among 2013 adults who were randomized, 1976 (98.2%) completed the trial (mean age, 48.8 years; 1381 [69.9%] women; 1778 [90.1%] underwent abdominal operations). In the intention-to-treat analysis, the primary outcome occurred in 211 of 989 patients (21.3%) in the high level of PEEP group compared with 233 of 987 patients (23.6%) in the low level of PEEP group (difference, -2.3% [95% CI, -5.9% to 1.4%]; risk ratio, 0.93 [95% CI, 0.83 to 1.04]; P =.23). Among the 9 prespecified secondary outcomes, 6 were not significantly different between the high and low level of PEEP groups, and 3 were significantly different, including fewer patients with hypoxemia (5.0% in the high level of PEEP group vs 13.6% in the low level of PEEP group; difference, -8.6% [95% CI, -11.1% to 6.1%]; P
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- 2019
13. Lung-protective ventilation in intensive care unit and operation room: Tidal volume size, level of positive end-expiratory pressure and driving pressure
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Serpa Neto, A., Schultz, Marcus J., Pelosi, P., Gama de Abreu, M., Hemmes, S. N. T., Graduate School, ACS - Pulmonary hypertension & thrombosis, Schultz, M.J., Hemmes, S.N.T., and Faculteit der Geneeskunde
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respiratory system - Abstract
Several investigations have shown independent associations between three ventilator settings – tidal volume size, positive end–expiratory pressure (PEEP) and driving pressure – and outcomes in patients with the acute respiratory distress syndrome (ARDS). There is an increasing notion that similar associations may exist between these ventilation parameters and outcomes in intensive care unit (ICU) patients without ARDS. Even in surgery patients, who usually receive mechanical ventilation for shorter periods of time than ICU patients, outcomes could depend on these three settings. The main aim of this thesis was to investigate associations between tidal volume size, PEEP and driving pressures, and outcomes in ICU patients without ARDS, patients receiving intraoperative ventilation, and patients receiving extracorporeal support as a rescue therapy for ARDS. We hypothesized that tidal volumes, PEEP and driving pressure are independently associated with outcomes in these groups of patients. The main findings are that three potentially modifiable ventilator settings – tidal volume, PEEP and driving pressure – have independent associations with diverse outcomes in ICU patients without ARDS, in surgery patients receiving intraoperative ventilation, and in ARDS patients under extracorporeal support. All these findings strongly support the idea that strategies aiming at optimization of these three settings could improve outcomes of patients receiving mechanical ventilatory support. We further suggest that one way to monitor the risk of damage caused by mechanical ventilation is to monitor the amount of energy transferred during mechanical ventilation. Finally, driving pressure itself is an important driver of the energy delivered by the ventilator to lung in each breath.
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- 2017
14. Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data
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Andrew Maslow, Juraj Sprung, Mohamed R. El-Tahan, Toby N. Weingarten, Thomas F. Schilling, Gabriele Selmo, Carmen Unzueta, Stavros G. Memtsoudis, Esther K. Wolthuis, Carmen Silvia Valente Barbas, Samir Jaber, Serdar Kokulu, Dinis dos Reis Miranda, Pierre Moine, Eduardo L. V. Costa, Sabrine N.T. Hemmes, V. Marco Ranieri, Paolo Pelosi, Daniel Talmor, Martin Beiderlinden, Tanja A. Treschan, Ognjen Gajic, Emmanuel Futier, Abdulmohsin A.Al Ghamdi, Wen Qian Lin, Alf Kozian, Thomas Ng, Domenico Paparella, Marcus J. Schultz, Marcelo B. P. Amato, Federica Scavonetto, Hermann Wrigge, Marc Licker, Ersin Günay, Marcelo Gama de Abreu, Ary Serpa Neto, Sugantha Sundar, Ana Fernandez-Bustamante, Paolo Severgnini, Intensive Care, Neto, A.S., Hemmes, S.N.T., Barbas, C.S.V., Beiderlinden, M., Fernandez-Bustamante, A., Futier, E., Gajic, O., El-Tahan, M.R., Ghamdi, A.A.A., Günay, E., Jaber, S., Kokulu, S., Kozian, A., Licker, M., Lin, W.-Q., Maslow, A.D., Memtsoudis, S.G., Miranda, D.R., Moine, P., Ng, T., Paparella, D., Ranieri, V.M., Scavonetto, F., Schilling, T., Selmo, G., Severgnini, P., Sprung, J., Sundar, S., Talmor, D., Treschan, T., Unzueta, C., Weingarten, T.N., Wolthuis, E.K., Wrigge, H., Amato, M.B.P., Costa, E.L.V., de Abreu, M.G., Pelosi, P., Schultz, M.J., Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Beth Israel Deaconess Medical Center [Boston] (BIDMC), Harvard Medical School [Boston] (HMS), UCPel - Universidade Catolica de Pelotas, Department of Intensive Care, Academic Medical Center, Department of Intensive Care, Academic Medical Center, University of Amsterdam, Intensive Care Medicine, Anesthesiology, Hospital Israelita Albert Einstein [São Paulo, Brazil], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement - Clermont Auvergne (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Département d'anesthésie-réanimation[Montpellier], and Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]
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Male ,lung disease ,procedure ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,driving pressure ,law.invention ,Positive-Pressure Respiration ,Plateau pressure ,Intraoperative Period ,0302 clinical medicine ,Randomized controlled trial ,systematic review ,030202 anesthesiology ,law ,middle aged ,lung complication ,General anaesthesia ,postoperative complication ,randomized controlled trial (topic) ,Tidal volume ,ComputingMilieux_MISCELLANEOUS ,Randomized Controlled Trials as Topic ,ddc:617 ,adult ,artificial ventilation ,respiratory system ,3. Good health ,driving pressure and development of postoperative pulmonary complications ,female ,priority journal ,Anesthesia ,positive end expiratory pressure ,Breathing ,pressure measurement ,circulatory and respiratory physiology ,Pulmonary and Respiratory Medicine ,tidal volume, Adult ,Lung injury ,Anesthesia, General ,Article ,03 medical and health sciences ,medicine ,Tidal Volume ,human ,intermethod comparison ,outcome assessment ,Aged ,Mechanical ventilation ,meta analysi ,business.industry ,disease association ,030208 emergency & critical care medicine ,Odds ratio ,general anesthesia ,respiratory tract diseases ,lung pressure ,business - Abstract
Background: Protective mechanical ventilation strategies using low tidal volume or high levels of positive end-expiratory pressure (PEEP) improve outcomes for patients who have had surgery. The role of the driving pressure, which is the difference between the plateau pressure and the level of positive end-expiratory pressure is not known. We investigated the association of tidal volume, the level of PEEP, and driving pressure during intraoperative ventilation with the development of postoperative pulmonary complications. Methods: We did a meta-analysis of individual patient data from randomised controlled trials of protective ventilation during general anesthaesia for surgery published up to July 30, 2015. The main outcome was development of postoperative pulmonary complications (postoperative lung injury, pulmonary infection, or barotrauma). Findings: We included data from 17 randomised controlled trials, including 2250 patients. Multivariate analysis suggested that driving pressure was associated with the development of postoperative pulmonary complications (odds ratio [OR] for one unit increase of driving pressure 1·16, 95% CI 1·13-1·19; p
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- 2016
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15. Protective versus Conventional Ventilation for Surgery: A Systematic Review and Individual Patient Data Meta-analysis
- Author
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Serpa Neto, Ary, Hemmes, Sabrine N. T., Barbas, Carmen S. V., Beiderlinden, Martin, Biehl, Michelle, Binnekade, Jan M., Canet, Jaume, Fernandez-Bustamante, Ana, Futier, Emmanuel, Gajic, Ognjen, Hedenstierna, Göran, Hollmann, Markus W., Jaber, Samir, Kozian, Alf, Licker, Marc, Lin, Wen-Qian, Maslow, Andrew D., Memtsoudis, Stavros G., Reis Miranda, Dinis, Moine, Pierre, Thomas, Ng, Paparella, Domenico, Putensen, Christian, Ranieri, Marco, Scavonetto, Federica, Schilling, Thomas, Schmid, Werner, Selmo, Gabriele, Severgnini, Paolo, Sprung, Juraj, Sundar, Sugantha, Talmor, Daniel, Treschan, Tanja, Unzueta, Carmen, Weingarten, Toby N., Wolthuis, Esther K., Wrigge, Hermann, Gama De Abreu, Marcelo, Pelosi, Paolo, Schultz, Marcus J., University of Amsterdam [Amsterdam] (UvA), Mayo Clinic [Rochester], CHU Clermont-Ferrand, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Otto-von-Guericke University [Magdeburg] (OVGU), University of Bari Aldo Moro (UNIBA), University of Insubria, Varese, Intensive Care, Serpa Neto, A., Hemmes, S.N.T., Barbas, C.S.V., Beiderlinden, M., Biehl, M., Binnekade, J.M., Canet, J., Fernandez-Bustamante, A., Futier, E., Gajic, O., Hedenstierna, G., Hollmann, M.W., Jaber, S., Kozian, A., Licker, M., Lin, W.-Q., Maslow, A.D., Memtsoudis, S.G., Reis Miranda, D., Moine, P., Ng, T., Paparella, D., Putensen, C., Ranieri, M., Scavonetto, F., Schilling, T., Schmid, W., Selmo, G., Severgnini, P., Sprung, J., Sundar, S., Talmor, D., Treschan, T., Unzueta, C., Weingarten, T.N., Wolthuis, E.K., Wrigge, H., Gama De Abreu, M., Pelosi, P., Schultz, M.J., Intensive Care Medicine, AII - Amsterdam institute for Infection and Immunity, Anesthesiology, Other Research, and ACS - Amsterdam Cardiovascular Sciences
- Subjects
general surgery ,ventilator ,procedure ,statistic ,[SDV]Life Sciences [q-bio] ,Statistics as Topic ,Article ,tidal volume, Human ,Positive-Pressure Respiration ,systematic review ,dose response ,patient coding ,lung complication ,Tidal Volume ,Humans ,postoperative complication ,human ,randomized controlled trial (topic) ,comparative study ,ComputingMilieux_MISCELLANEOUS ,Randomized Controlled Trials as Topic ,meta analysi ,Respiration ,standard ,artificial ventilation ,Respiration, Artificial ,Anesthesiology and Pain Medicine ,priority journal ,risk factor ,positive end expiratory pressure ,Artificial ,physiology - Abstract
Background: Recent studies show that intraoperative mechanical ventilation using low tidal volumes (V-T) can prevent postoperative pulmonary complications (PPCs). The aim of this individual patient data meta-analysis is to evaluate the individual associations between V-T size and positive end-expiratory pressure (PEEP) level and occurrence of PPC. Methods: Randomized controlled trials comparing protective ventilation (low V-T with or without high levels of PEEP) and conventional ventilation (high V-T with low PEEP) in patients undergoing general surgery. The primary outcome was development of PPC. Predefined prognostic factors were tested using multivariate logistic regression. Results: Fifteen randomized controlled trials were included (2,127 patients). There were 97 cases of PPC in 1,118 patients (8.7%) assigned to protective ventilation and 148 cases in 1,009 patients (14.7%) assigned to conventional ventilation (adjusted relative risk, 0.64; 95% CI, 0.46 to 0.88; P < 0.01). There were 85 cases of PPC in 957 patients (8.9%) assigned to ventilation with low V-T and high PEEP levels and 63 cases in 525 patients (12%) assigned to ventilation with low V-T and low PEEP levels (adjusted relative risk, 0.93; 95% CI, 0.64 to 1.37; P = 0.72). A dose-response relationship was found between the appearance of PPC and V-T size (R-2 = 0.39) but not between the appearance of PPC and PEEP level (R-2 = 0.08). Conclusions: These data support the beneficial effects of ventilation with use of low V-T in patients undergoing surgery. Further trials are necessary to define the role of intraoperative higher PEEP to prevent PPC during nonopen abdominal surgery.
- Published
- 2015
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