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734 results on '"Hemingway, Janet"'

1. LLIN Evaluation in Uganda Project (LLINEUP)–effects of a vector control trial on Plasmodium infection prevalence and genotypic markers of insecticide resistance in Anopheles vectors from 48 districts of Uganda

Author

Lynd, Amy, Gonahasa, Samuel, Staedke, Sarah G., Oruni, Ambrose, Maiteki-Sebuguzi, Catherine, Hancock, Penelope A., Knight, Erin, Dorsey, Grant, Opigo, Jimmy, Yeka, Adoke, Katureebe, Agaba, Kyohere, Mary, Hemingway, Janet, Kamya, Moses R., McDermott, Daniel, Lucas, Eric R., and Donnelly, Martin J.

Published
2024
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2. Evaluation of an accelerometer-based monitor for detecting bed net use and human entry/exit using a machine learning algorithm

Author

Koudou, Guibehi B, Monroe, April, Irish, Seth R, Humes, Michael, Krezanoski, Joseph D, Koenker, Hannah, Malone, David, Hemingway, Janet, and Krezanoski, Paul J

Subjects
Microbiology, Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Good Health and Well Being, Accelerometry, Adult, Algorithms, Child, Cross-Sectional Studies, Humans, Insecticide-Treated Bednets, Machine Learning, Mosquito Control, Malaria prevention, Bed net use, Machine learning, Public Health and Health Services, Tropical Medicine, Medical microbiology, Public health
Abstract

BackgroundDistribution of long-lasting insecticidal bed nets (LLINs) is one of the main control strategies for malaria. Improving malaria prevention programmes requires understanding usage patterns in households receiving LLINs, but there are limits to what standard cross-sectional surveys of self-reported LLIN use can provide. This study was designed to assess the performance of an accelerometer-based approach for measuring a range of LLIN use behaviours as a proof of concept for more granular LLIN-use monitoring over longer time periods.MethodsThis study was carried out under controlled conditions from May to July 2018 in Liverpool, UK. A single accelerometer was affixed to the side panel of an LLIN and participants carried out five LLIN use behaviours: (1) unfurling a net; (2) entering an unfurled net; (3) lying still as if sleeping; (4) exiting from under a net; and, (5) folding up a net. The randomForest package in R, a supervised non-linear classification algorithm, was used to train models on 20-s epochs of tagged accelerometer data. Models were compared in a validation dataset using overall accuracy, sensitivity and specificity, receiver operating curves and the area under the curve (AUC).ResultsThe five-category model had overall accuracy of 82.9% in the validation dataset, a sensitivity of 0.681 for entering a net, 0.632 for exiting, 0.733 for net down, and 0.800 for net up. A simplified four-category model, combining entering/exiting a net into one category had accuracy of 94.8%, and increased sensitivity for net down (0.756) and net up (0.829). A further simplified three-category model, identifying sleeping, net up, and a combined net down/enter/exit category had accuracy of 96.2% (483/502), with an AUC of 0.997 for net down and 0.987 for net up. Models for detecting entering/exiting by adults were significantly more accurate than for children (87.8% vs 70.0%; p

Published
2022

3. Core commitments for field trials of gene drive organisms.

Author

Long, Kanya C, Alphey, Luke, Annas, George J, Bloss, Cinnamon S, Campbell, Karl J, Champer, Jackson, Chen, Chun-Hong, Choudhary, Amit, Church, George M, Collins, James P, Cooper, Kimberly L, Delborne, Jason A, Edwards, Owain R, Emerson, Claudia I, Esvelt, Kevin, Evans, Sam Weiss, Friedman, Robert M, Gantz, Valentino M, Gould, Fred, Hartley, Sarah, Heitman, Elizabeth, Hemingway, Janet, Kanuka, Hirotaka, Kuzma, Jennifer, Lavery, James V, Lee, Yoosook, Lorenzen, Marce, Lunshof, Jeantine E, Marshall, John M, Messer, Philipp W, Montell, Craig, Oye, Kenneth A, Palmer, Megan J, Papathanos, Philippos Aris, Paradkar, Prasad N, Piaggio, Antoinette J, Rasgon, Jason L, Rašić, Gordana, Rudenko, Larisa, Saah, J Royden, Scott, Maxwell J, Sutton, Jolene T, Vorsino, Adam E, and Akbari, Omar S

Subjects
Animals, Organisms, Genetically Modified, Safety, Guidelines as Topic, Gene Drive Technology, Genetics, Generic health relevance, General Science & Technology
Abstract

We must ensure that trials are scientifically, politically, and socially robust, publicly accountable, and widely transparent

Published
2020

5. Global water quality changes posing threat of increasing infectious diseases, a case study on malaria vector Anopheles stephensi coping with the water pollutants using age-stage, two-sex life table method

Author

Fazeli-Dinan, Mahmoud, Azarnoosh, Mostafa, Özgökçe, Mehmet Salih, Chi, Hsin, Hosseini-Vasoukolaei, Nasibeh, Haghi, Farzad Motevalli, Zazouli, Mohamad Ali, Nikookar, Seyed Hassan, Dehbandi, Reza, Enayati, Ahmadali, Zaim, Morteza, and Hemingway, Janet

Published
2022
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7. LLIN evaluation in Uganda project (LLINEUP): The fabric integrity, chemical content and bioefficacy of long-lasting insecticidal nets treated with and without piperonyl butoxide across two years of operational use in Uganda

Author

Mechan, Frank, Katureebe, Agaba, Tuhaise, Violet, Mugote, Martin, Oruni, Ambrose, Onyige, Ismail, Bumali, Kawesa, Thornton, Jonathan, Maxwell, Kilama, Kyohere, Mary, Kamya, Moses R., Mutungi, Peter, Kigozi, Simon P., Yeka, Adoke, Opigo, Jimmy, Maiteki-Sebuguzi, Catherine, Gonahasa, Samuel, Hemingway, Janet, Dorsey, Grant, Reimer, Lisa J., Staedke, Sarah G., Donnelly, Martin J., and Lynd, Amy

Published
2022
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9. AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis

Author

Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., and O’Neill, Paul M.

Published
2019

11. LLIN Evaluation in Uganda Project (LLINEUP) -Plasmodiuminfection prevalence and genotypic markers of insecticide resistance inAnophelesvectors from 48 districts of Uganda

Author

Lynd, Amy R, primary, Gonahasa, Samuel, additional, Staedke, Sarah G, additional, Oruni, Ambrose, additional, Maiteki-Sebuguzi, Catherine, additional, Hancock, Penelope A, additional, Knight, Erin, additional, Dorsey, Grant, additional, Opigo, Jimmy, additional, Yeka, Adoke, additional, Katureebe, Agaba, additional, Kyohere, Mary, additional, Hemingway, Janet, additional, Kamya, Moses R, additional, McDermott, Daniel, additional, Lucas, Eric R, additional, and Donnelly, Martin James, additional

Published
2023
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14. Response

Author

Hemingway, Janet

Published
2018

15. Impact of insecticide resistance in Anopheles arabiensis on malaria incidence and prevalence in Sudan and the costs of mitigation

Author

Kafy, Hmooda Toto, Ismail, Bashir Adam, Mnzava, Abraham Peter, Lines, Jonathan, Abdin, Mogahid Shiekh Eldin, Eltaher, Jihad Sulieman, Banaga, Anuar Osman, West, Philippa, Bradley, John, Cook, Jackie, Thomas, Brent, Subramaniam, Krishanthi, Hemingway, Janet, Knox, Tessa Bellamy, Malik, Elfatih M., Yukich, Joshua O., Donnelly, Martin James, and Kleinschmidt, Immo

Published
2017

17. Albendazole and antibiotics synergize to deliver short-course anti- Wolbachia curative treatments in preclinical models of filariasis

Author

Turner, Joseph D., Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Priestley, Richard S., Murphy, Emma A., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., McCall, John, Ford, Louise, Hemingway, Janet, Ward, Stephen A., and Taylor, Mark J.

Published
2017

33. Malaria Control with Genetically Manipulated Insect Vectors

Author

Alphey, Luke, Ben Beard, C., Billingsley, Peter, Coetzee, Maureen, Crisanti, Andrea, Curtis, Chris, Eggleston, Paul, Godfray, Charles, Hemingway, Janet, Jacobs-Lorena, Marcelo, James, Anthony A., Kafatos, Fotis C., Mukwaya, Louis G., Paton, Michael, Powell, Jeffrey R., Schneider, William, Scott, Thomas W., Sina, Barbara, Sinden, Robert, Sinkins, Steven, Spielman, Andrew, Touré, Yeya, and Collins, Frank H.

Published
2002

39. An operational framework for insecticide resistance management planning

Author

Chanda, Emmanuel, Thomsen, Edward K., Musapa, Mulenga, Kamuliwo, Mulakwa, Brogdon, William G., Norris, Douglas E., Masaninga, Freddie, Wirtz, Robert, Sikaala, Chadwick H., Muleba, Mbanga, Craig, Allen, Govere, John M., Ranson, Hilary, Hemingway, Janet, Seyoum, Aklilu, Macdonald, Michael B., and Coleman, Michael

Subjects
Infection control, Mosquitoes -- Control, Insecticide resistance -- Forecasts and trends, Market trend/market analysis, Health
Abstract

Emerging and reemerging infectious diseases are often transmitted by arthropod vectors (1,2). A primary strategy to reduce vectorborne disease transmission is the use of insecticides for public health. However, resistance [...]

Published
2016
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40. Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment

Author

Quek, Shannon, Cook, Darren, Wu, Yang, Marriott, Amy, Steven, Andrew, Johnston, Kelly, Ford, Louise, Archer, John, Hemingway, Janet, Ward, Steve, Wagstaff, Simon, Turner, Joseph, and Taylor, Mark

Subjects
wc_880, qx_20, qw_150
Abstract

Lymphatic filariasis is a vector-borne neglected tropical disease prioritized for global elimination. The filarial nematodes that cause the disease host a symbiotic bacterium, Wolbachia, which has been targeted using antibiotics, leading to cessation of parasite embryogenesis, waning of circulating larvae (microfilariae [mf]), and gradual cure of adult infection. One of the benefits of the anti-Wolbachia mode of action is that it avoids the rapid killing of mf, which can drive inflammatory adverse events. However, mf depleted of Wolbachia persist for several months in circulation, and thus patients treated with antibiotics are assumed to remain at risk for transmitting infections. Here, we show that Wolbachia-depleted mf rapidly lose the capacity to develop in the mosquito vector through a defect in exsheathment and inability to migrate through the gut wall. Transcriptomic and Western blotting analyses demonstrate that chitinase, an enzyme essential for mf exsheathment, is down-regulated in Wolbachia-depleted mf and correlates with their inability to exsheath and escape the mosquito midgut. Supplementation of in vitro cultures of Wolbachia-depleted mf with chitinase enzymes restores their ability to exsheath to a similar level to that observed in untreated mf. Our findings elucidate a mechanism of rapid transmission-blocking activity of filariasis after depletion of Wolbachia and adds to the broad range of biological processes of filarial nematodes that are dependent on Wolbachia symbiosis.

Published
2022

41. Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): final results of a cluster-randomised trial embedded in a national distribution campaign

Author

Maiteki-Sebuguzi, Catherine, Gonahasa, Samuel, Kamya, Moses R, Katureebe, Agaba, Bagala, Irene, Lynd, Amy, Mutungi, Peter, Kigozi, Simon P, Opigo, Jimmy, Hemingway, Janet, Dorsey, Grant, Donnelly, Martin, and Staedke, Sarah G

Subjects
Infectious Diseases, qx_600, wa_240, wc_765, wa_110, wa_20_5, wc_750
Abstract

Long-lasting insecticidal nets (LLINs) are the foundation of malaria control but resistance of mosquito vectors to pyrethroids threatens their effectiveness. We embedded a cluster-randomised trial into Uganda's 2017-18 campaign to distribute LLINs. LLINs with piperonyl butoxide (PBO) reduced parasite prevalence more effectively than conventional LLINs (without PBO) for 18 months. Here, we report the final 25-month survey results.LLINEUP was a cluster-randomised trial conducted in 48 districts in eastern and western Uganda. 104 health subdistricts (clusters) without ongoing or planned indoor residual spraying with pirimiphos-methyl (Actellic, Basel, Switzerland) were eligible for inclusion in the trial. Clusters were randomly assigned to PBO LLINs (PermaNet 3.0 or Olyset Plus) and conventional LLINs (PermaNet 2.0 or Olyset Net) with proportionate randomisation using STATA version 14.2. LLINs were delivered from March 25, 2017, to March 18, 2018. Between April 23, 2019, and Sept 13, 2019, community surveys were conducted in 50 randomly selected households per cluster; ten households per cluster were randomly selected for entomology surveys. Mosquitoes were collected in the morning from indoor surfaces of households using Prokopack aspirators. Due to COVID-19 restrictions, only 90 of the 104 clusters were surveyed at 25 months. The primary outcome was parasite prevalence by microscopy in children aged 2-10 years, assessed in the as-treated population, determined using the results from the 6-month household survey on the type of LLINs received in each cluster. This trial is registered with ISRCTN, ISRCTN17516395, and is now completed.In the as-treated analysis, two clusters were excluded (no predominant LLIN received) and four were reassigned; 40 PBO LLIN clusters (30 PermaNet 3.0, ten Olyset Plus) and 48 non-PBO LLIN (36 PermaNet 2.0, 12 Olyset Net) were included. Parasite prevalence was 17·1% (506 of 2958 participants) in the PBO group and 19·8% (701 of 3534) in the non-PBO group (prevalence ratio adjusted for baseline 0·80 [95% CI 0·69-0·93], p=0·0048). Comparing within-treatment group parasite prevalence to baseline, parasite prevalence ratios were lower in the PBO groups at all timepoints, but the difference was greatest at 6 months (PBO LLINs parasite prevalence at baseline 28·8% [1001 of 3472, 95% CI 27·3-30·4] vs at 6 months 12·0% [361 of 3009, 10·9-13·2], prevalence ratio [PR] 0·43 [95% CI 0·36-0·52], p0·0001; non-PBO LLINs parasite prevalence at baseline 25·4% [1015 of 4004, 24·0-26·7] vs 6 months 14·8% [526 of 3551, 13·7-16·0], PR 0·60 [0·54-0·68], p0·0001) and 25 months (PBO LLINs parasite prevalence at 25 months 17·1% [506 of 2958, 15·8-18·5], PR 0·63 [95% CI 0·57-0·71], p0·0001; non-PBO LLINs parasite prevalence at 25 months 19·8% [701 of 3534, 18·5-21·2], PR 0·79 [0·73-0·86], p0·0001).In Uganda, PBO LLINs outperformed pyrethroid-only LLINs for 25 months. WHO concluded that PBO LLINs are more effective against malaria than non-PBO LLINs when resistance to pyrethroids is high and issued a conditional recommendation suggesting PBO LLINs should be deployed in areas of pyrethroid resistance.The Against Malaria Foundation, UK Department for International Development, Innovative Vector Control Consortium, and Bill and Melinda Gates Foundation.

Published
2022

42. Strain Characterisation for Measuring Bioefficacy of ITNs Treated with Two Active Ingredients (Dual-AI ITNs): Developing a Robust Protocol by Building Consensus

Author

Lees, Rosemary, primary, Armistead, Jennifer, additional, Azizi, Salum, additional, Constant, Edi, additional, Fornadel, Christen, additional, Gimnig, John, additional, Hemingway, Janet, additional, Impoinvil, Daniel, additional, Irish, Seth, additional, Kisinza, William, additional, Lissenden, Natalie, additional, Mawejje, Henry, additional, Messenger, Louisa, additional, Moore, Sarah, additional, Ngufor, Corine, additional, Oxborough, Richard, additional, Protopopoff, Natacha, additional, Ranson, Hilary, additional, Small, Graham, additional, Wagman, Joseph, additional, Weetman, David, additional, Zohdy, Sarah, additional, and Spiers, Angus, additional

Published
2022
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44. Additional file 1 of Evaluation of an accelerometer-based monitor for detecting bed net use and human entry/exit using a machine learning algorithm

Author

Koudou, Guibehi B., Monroe, April, Irish, Seth R., Humes, Michael, Krezanoski, Joseph D., Koenker, Hannah, Malone, David, Hemingway, Janet, and Krezanoski, Paul J.

Abstract

Additional file 1. Confusion matrices and importance plot. Additional data to aid in the interpretation of random forest classifications.

Published
2022
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46. Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Author

Biagini, Giancarlo A., Fisher, Nicholas, Shone, Alison E., Mubaraki, Murad A., Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J., Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K., Leung, Suet C., Sharma, Raman, Gibbons, Peter, Hong, David W., Pacorel, Bénédicte, Lawrenson, Alexandre S., Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A., Nixon, Gemma L., Chadwick, James, Hemingway, Janet, Delves, Michael J., Sinden, Robert E., Zeeman, Anne-Marie, Kocken, Clemens H. M., Berry, Neil G., O'Neill, Paul M., and Ward, Stephen A.

Published
2012

48. Strain Characterisation for Measuring Bioefficacy of ITNs Treated with Two Active Ingredients (Dual-AI ITNs): Developing a Robust Protocol by Building Consensus

Author

Lees, Rosemary Susan, primary, Armistead, Jennifer S, additional, Azizi, Salum, additional, Constant, Edi, additional, Fornadel, Christen, additional, Gimnig, John E, additional, Hemingway, Janet, additional, Impoinvil, Daniel, additional, Irish, Seth R, additional, Kisinza, William, additional, Lissenden, Natalie, additional, Mawejje, Henry D, additional, Messenger, Louisa A, additional, Moore, Sarah, additional, Ngufor, Corine, additional, Oxborough, Richard, additional, Protopopoff, Natacha, additional, Ranson, Hilary, additional, Small, Graham, additional, Wagman, Joseph, additional, Weetman, David, additional, Zohdy, Sarah, additional, and Spiers, Angus, additional

Published
2022
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49. LLIN Evaluation in Uganda Project (LLINEUP) – The durability of long-lasting insecticidal nets treated with and without piperonyl butoxide (PBO) in Uganda

Author

Mechan, Frank, primary, Katureebe, Agaba, additional, Tuhaise, Violet, additional, Mugote, Martin, additional, Oruni, Ambrose, additional, Onyige, Ismail, additional, Bumali, Kawesa, additional, Thornton, Jonathan, additional, Maxwell, Kilama, additional, Kyohere, Mary, additional, Kamya, Moses R, additional, Mutungi, Peter, additional, Kigozi, Simon P, additional, Yeka, Adoke, additional, Opigo, Jimmy, additional, Maiteki-Sebuguzi, Catherine, additional, Gonahasa, Samuel, additional, Hemingway, Janet, additional, Dorsey, Grant, additional, Reimer, Lisa J, additional, Staedke, Sarah G, additional, Donnelly, Martin J, additional, and Lynd, Amy, additional

Published
2022
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50. LLIN Evaluation in Uganda Project (LLINEUP) – Effect of Long-Lasting Insecticidal Nets with and Without Piperonyl Butoxide on Malaria Indicators in Uganda 25 Months after Distribution: A Cluster-Randomised Trial

Author

Maiteki-Sebuguzi, Catherine, primary, Gonahasa, Samuel, additional, Sherrard-Smith, Ellie, additional, Kamya, Moses, additional, Katureebe, Agaba, additional, Bagala, Irene, additional, lynd, amy, additional, Mutungi, Peter, additional, Kigozi, Simon P., additional, Opigo, Jimmy, additional, Churcher, Thomas S., additional, Hemingway, Janet, additional, Dorsey, Grant, additional, Donnelly, Martin, additional, and Staedke, Sarah, additional

Published
2022
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