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Vortioxetine an anti-depressant FDA-drug recently reported showing better in vitro efficacy against SARS-CoV-2.In this study, we have synthesized ten new derivatives having alkenes, alkynes, benzyl, aryl, and mixed carbamate at the N-terminal of vortioxetine. Then the binding energy and interactions with the crucial amino acid residues in the binding pocket of main protease (MBased on the docking scores predicted by ADV and AD, most vortioxetine derivatives showed better binding efficiency towards MThis study shows that some vortioxetine derivatives can be developed into promising drugs for COVID-19 treatment.

In order to identify a suitable alternative to non-steroidal anti-inflammatory drugs (NSAIDs) we aimed to develop derivatives of vortioxetine, a multimodal anti-depressive drug that has been shownpreviously to be endowed withanti-inflammatory activity in human monocytes/macrophages. Vortioxetine (1) was synthesized in good yield and different alkyl and aryl derivatives were prepared based on their structural diversity and easy availability. The compounds were tested on human monocytes isolated from healthy donors for theireffect on superoxide anion production and cytokine gene expression, and for COX-1/2 gene expression and activity modulation. Moreover, a docking study was performed to predict the interactions between the synthesized compounds and COX-1 and COX-2. Correlating experimental biological data to the molecular modelling studies, it emerged that among the novel compounds, 6 was endowed of antioxidant and anti-COX-1 activity, vortioxetine and 3 were good antioxidants and mild anti-COX-1/2 inhibitors, while 7 was a good anti-COX-1/2 inhibitor and 11 was more specific versus COX-2.

With the growth of communication/transaction over internet and continuous efforts by cryptanalysts there is a continuous need for strong cryptographic algorithms. The primary goal, for designing such algorithms, is to provide security. However, performance and implementation ease and execution time are other factors that make an algorithm more usable. An improved encryption model, which is an extension of an existing encryption algorithm based on UNICODE and Colors map can be used. The cipher text that is generated by using improved encryption model is of the same size as the plain text and it will be suitable for practical use in the secure transmission of confidential information over the Internet.