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206 results on '"Helzlsouer, K J"'

2. Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies

Author

Genkinger, J. M., Kitahara, C. M., Bernstein, L., Berrington de Gonzalez, A., Brotzman, M., Elena, J. W., Giles, G. G., Hartge, P., Singh, P. N., Stolzenberg-Solomon, R. Z., Weiderpass, E., Adami, H.-O., Anderson, K. E., Beane-Freeman, L. E., Buring, J. E., Fraser, G. E., Fuchs, C. S., Gapstur, S. M., Gaziano, J. M., Helzlsouer, K. J., Lacey, J. V., Jr, Linet, M. S., Liu, J. J., Park, Y., Peters, U., Purdue, M. P., Robien, K., Schairer, C., Sesso, H. D., Visvanathan, K., White, E., Wolk, A., Wolpin, B. M., Zeleniuch-Jacquotte, A., and Jacobs, E. J.

Published
2015
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9. A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk

Author

Travis, RC, Appleby, P N, Martin, RM, Holly, JMP, Albanes, D, Black, A, Bueno-de-Mesquita, HB, Chan, JM, Chen, C (Christopher Li Hsian), Chirlaque, MD, Cook, M B, Deschasaux, M, Donovan, JL, Ferrucci, L, Galan, P, Giles, GG, Giovannucci, E L, Gunter, MJ, Habel, L A, Hamdy, FC, Helzlsouer, K J, Hercberg, S, Hoover, RN, Janssen, J.A.M.J.L., Kaaks, R, Kubo, T, Le Marchand, L, Metter, EJ, Mikami, K, Morris, J K, Neal, DE, Neuhouser, ML, Ozasa, K, Palli, D, Platz, EA, Pollak, MN, Price, AJ, Roobol - Bouts, Monique, Schaefer, C, Schenk, J M, Severi, G, Stampfer, MJ, Stattin, P, Tamakoshi, A, Tangen, C M, Touvier, M, Wald, N J, Weiss, NS, Ziegler, RG, Key, TJ, Allen, NE, Endogenous Hormones, Nutr, Internal Medicine, and Urology

Subjects
SDG 3 - Good Health and Well-being
Published
2016

10. Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies

Author

Key, T. J., Appleby, P. N., Reeves, G. K., Travis, R. C., Brinton, L. A., Dallal, C. M., Helzlsouer, K. J., Hoffman-Bolton, J., Visvanathan, K., Dorgan, J. F., Falk, R. T., Gapstur, S. M., Gaudet, M. M., Kaaks, R., Riboli, E., Rinaldi, S., Key, T., Manjer, Jonas, Hallmans, G., Giles, G. G., Le Marchand, L., Kolonel, L. N., Henderson, B. E., Tworoger, S. S., Hankinson, S. E., Zeleniuch-Jacquotte, A., Koenig, K., Krogh, V., Sieri, S., Muti, P., Ziegler, R. G., Schairer, C., Fuhrman, B. J., Barrett-Connor, E., Laughlin, G. A., Grant, E. J., Cologne, J., Ohishi, W., Hida, A., Cauley, J. A., Fourkala, E.-O., Rohan, T. E., Strickler, H. D., Gunter, M. J., Key, T. J., Appleby, P. N., Reeves, G. K., Travis, R. C., Brinton, L. A., Dallal, C. M., Helzlsouer, K. J., Hoffman-Bolton, J., Visvanathan, K., Dorgan, J. F., Falk, R. T., Gapstur, S. M., Gaudet, M. M., Kaaks, R., Riboli, E., Rinaldi, S., Key, T., Manjer, Jonas, Hallmans, G., Giles, G. G., Le Marchand, L., Kolonel, L. N., Henderson, B. E., Tworoger, S. S., Hankinson, S. E., Zeleniuch-Jacquotte, A., Koenig, K., Krogh, V., Sieri, S., Muti, P., Ziegler, R. G., Schairer, C., Fuhrman, B. J., Barrett-Connor, E., Laughlin, G. A., Grant, E. J., Cologne, J., Ohishi, W., Hida, A., Cauley, J. A., Fourkala, E.-O., Rohan, T. E., Strickler, H. D., and Gunter, M. J.

Abstract

Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study.

Published
2015

11. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

Author

Key, T. J. Appleby, P. N. Reeves, G. K. Roddam, A. W. and Helzlsouer, K. J. Alberg, A. J. Rollison, D. E. Dorgan, J. F. Brinton, L. A. Overvad, K. Kaaks, R. Trichopoulou, A. and Clavel-Chapelon, F. Panico, S. Duell, E. J. Peeters, P. H. M. Rinaldi, S. Riboli, E. Fentiman, I. S. Dowsett, M. and Manjer, J. Lenner, P. Hallmans, G. Baglietto, L. and English, D. R. Giles, G. G. Hopper, J. L. Severi, G. and Morris, H. A. Koenig, K. Zeleniuch-Jacquotte, A. Arslan, A. A. Toniolo, P. Shore, R. E. Krogh, V. Micheli, A. and Berrino, F. Muti, P. Barrett-Connor, E. Laughlin, G. A. and Kabuto, M. Akiba, S. Stevens, R. G. Neriishi, K. Land, C. E. Cauley, J. A. Lui, Li Yung Cummings, Steven R. and Gunter, M. J. Rohan, T. E. Strickler, H. D. Endogenous Hormones Breast Canc

Abstract

BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. British Journal of Cancer (2011) 105, 709-722. doi:10.1038/bjc.2011.254 www.bjcancer.com Published online 19 July 2011 (C) 2011 Cancer Research UK

Published
2011

12. Circulating sex hormones and breast cancer risk factors in postmenopausal women : reanalysis of 13 studies.

Author

Key, T J, Appleby, P N, Reeves, G K, Roddam, A W, Helzlsouer, K J, Alberg, A J, Rollison, D E, Dorgan, J F, Brinton, L A, Overvad, K, Kaaks, R, Trichopoulou, A, Clavel-Chapelon, F, Panico, S, Duell, E J, Peeters, P H M, Rinaldi, S, Fentiman, I S, Dowsett, M, Manjer, J, Lenner, Per, Hallmans, Göran, Baglietto, L, English, D R, Giles, G G, Hopper, J L, Severi, G, Morris, H A, Hankinson, S E, Tworoger, S S, Koenig, K, Zeleniuch-Jacquotte, A, Arslan, A A, Toniolo, P, Shore, R E, Krogh, V, Micheli, A, Berrino, F, Barrett-Connor, E, Laughlin, G A, Kabuto, M, Akiba, S, Stevens, R G, Neriishi, K, Land, C E, Cauley, J A, Lui, Li Yung, Cummings, Steven R, Gunter, M J, Rohan, T E, Strickler, H D, Key, T J, Appleby, P N, Reeves, G K, Roddam, A W, Helzlsouer, K J, Alberg, A J, Rollison, D E, Dorgan, J F, Brinton, L A, Overvad, K, Kaaks, R, Trichopoulou, A, Clavel-Chapelon, F, Panico, S, Duell, E J, Peeters, P H M, Rinaldi, S, Fentiman, I S, Dowsett, M, Manjer, J, Lenner, Per, Hallmans, Göran, Baglietto, L, English, D R, Giles, G G, Hopper, J L, Severi, G, Morris, H A, Hankinson, S E, Tworoger, S S, Koenig, K, Zeleniuch-Jacquotte, A, Arslan, A A, Toniolo, P, Shore, R E, Krogh, V, Micheli, A, Berrino, F, Barrett-Connor, E, Laughlin, G A, Kabuto, M, Akiba, S, Stevens, R G, Neriishi, K, Land, C E, Cauley, J A, Lui, Li Yung, Cummings, Steven R, Gunter, M J, Rohan, T E, and Strickler, H D

Abstract

BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.

Published
2011
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17. Circulating 25-Hydroxyvitamin D and Risk of Epithelial Ovarian Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Zheng, W., primary, Danforth, K. N., additional, Tworoger, S. S., additional, Goodman, M. T., additional, Arslan, A. A., additional, Patel, A. V., additional, McCullough, M. L., additional, Weinstein, S. J., additional, Kolonel, L. N., additional, Purdue, M. P., additional, Shu, X.-O., additional, Snyder, K., additional, Steplowski, E., additional, Visvanathan, K., additional, Yu, K., additional, Zeleniuch-Jacquotte, A., additional, Gao, Y.-T., additional, Hankinson, S. E., additional, Harvey, C., additional, Hayes, R. B., additional, Henderson, B. E., additional, Horst, R. L., additional, and Helzlsouer, K. J., additional

Published
2010
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18. Circulating 25-Hydroxyvitamin D and Risk of Non-Hodgkin Lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Purdue, M. P., primary, Freedman, D. M., additional, Gapstur, S. M., additional, Helzlsouer, K. J., additional, Laden, F., additional, Lim, U., additional, Maskarinec, G., additional, Rothman, N., additional, Shu, X.-O., additional, Stevens, V. L., additional, Zeleniuch-Jacquotte, A., additional, Albanes, D., additional, Bertrand, K., additional, Weinstein, S. J., additional, Yu, K., additional, Irish, L., additional, Horst, R. L., additional, Hoffman-Bolton, J., additional, Giovannucci, E. L., additional, Kolonel, L. N., additional, Snyder, K., additional, Willett, W., additional, Arslan, A. A., additional, Hayes, R. B., additional, Zheng, W., additional, Xiang, Y.-B., additional, and Hartge, P., additional

Published
2010
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19. Circulating 25-Hydroxyvitamin D and Risk of Kidney Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Gallicchio, L., primary, Moore, L. E., additional, Stevens, V. L., additional, Ahn, J., additional, Albanes, D., additional, Hartmuller, V., additional, Setiawan, V. W., additional, Helzlsouer, K. J., additional, Yang, G., additional, Xiang, Y.-B., additional, Shu, X.-O., additional, Snyder, K., additional, Weinstein, S. J., additional, Yu, K., additional, Zeleniuch-Jacquotte, A., additional, Zheng, W., additional, Cai, Q., additional, Campbell, D. S., additional, Chen, Y., additional, Chow, W.-H., additional, Horst, R. L., additional, Kolonel, L. N., additional, McCullough, M. L., additional, Purdue, M. P., additional, and Koenig, K. L., additional

Published
2010
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20. Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Abnet, C. C., primary, Chen, Y., additional, Chow, W.-H., additional, Gao, Y.-T., additional, Helzlsouer, K. J., additional, Le Marchand, L., additional, McCullough, M. L., additional, Shikany, J. M., additional, Virtamo, J., additional, Weinstein, S. J., additional, Xiang, Y.-B., additional, Yu, K., additional, Zheng, W., additional, Albanes, D., additional, Arslan, A. A., additional, Campbell, D. S., additional, Campbell, P. T., additional, Hayes, R. B., additional, Horst, R. L., additional, Kolonel, L. N., additional, Nomura, A. M. Y., additional, Purdue, M. P., additional, Snyder, K., additional, and Shu, X.-O., additional

Published
2010
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21. Circulating 25-Hydroxyvitamin D and Risk of Pancreatic Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Stolzenberg-Solomon, R. Z., primary, Jacobs, E. J., additional, Arslan, A. A., additional, Qi, D., additional, Patel, A. V., additional, Helzlsouer, K. J., additional, Weinstein, S. J., additional, McCullough, M. L., additional, Purdue, M. P., additional, Shu, X.-O., additional, Snyder, K., additional, Virtamo, J., additional, Wilkins, L. R., additional, Yu, K., additional, Zeleniuch-Jacquotte, A., additional, Zheng, W., additional, Albanes, D., additional, Cai, Q., additional, Harvey, C., additional, Hayes, R., additional, Clipp, S., additional, Horst, R. L., additional, Irish, L., additional, Koenig, K., additional, Le Marchand, L., additional, and Kolonel, L. N., additional

Published
2010
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22. Circulating 25-Hydroxyvitamin D and Risk of Endometrial Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Zeleniuch-Jacquotte, A., primary, Gallicchio, L., additional, Hartmuller, V., additional, Helzlsouer, K. J., additional, McCullough, M. L., additional, Setiawan, V. W., additional, Shu, X.-O., additional, Weinstein, S. J., additional, Weiss, J. M., additional, Arslan, A. A., additional, De Vivo, I., additional, Gao, Y.-T., additional, Hayes, R. B., additional, Henderson, B. E., additional, Horst, R. L., additional, Koenig, K. L., additional, Patel, A. V., additional, Purdue, M. P., additional, Snyder, K., additional, Steplowski, E., additional, Yu, K., additional, Zheng, W., additional, and Hankinson, S. E., additional

Published
2010
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23. Circulating 25-Hydroxyvitamin D and the Risk of Rarer Cancers: Design and Methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Gallicchio, L., primary, Helzlsouer, K. J., additional, Chow, W.-H., additional, Freedman, D. M., additional, Hankinson, S. E., additional, Hartge, P., additional, Hartmuller, V., additional, Harvey, C., additional, Hayes, R. B., additional, Horst, R. L., additional, Koenig, K. L., additional, Kolonel, L. N., additional, Laden, F., additional, McCullough, M. L., additional, Parisi, D., additional, Purdue, M. P., additional, Shu, X.-O., additional, Snyder, K., additional, Stolzenberg-Solomon, R. Z., additional, Tworoger, S. S., additional, Varanasi, A., additional, Virtamo, J., additional, Wilkens, L. R., additional, Xiang, Y.-B., additional, Yu, K., additional, Zeleniuch-Jacquotte, A., additional, Zheng, W., additional, Abnet, C. C., additional, Albanes, D., additional, Bertrand, K., additional, and Weinstein, S. J., additional

Published
2010
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25. Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study

Author

Kempen, J. H, primary, Daniel, E., additional, Dunn, J. P, additional, Foster, C S., additional, Gangaputra, S., additional, Hanish, A., additional, Helzlsouer, K. J, additional, Jabs, D. A, additional, Kacmaz, R O., additional, Levy-Clarke, G. A, additional, Liesegang, T. L, additional, Newcomb, C. W, additional, Nussenblatt, R. B, additional, Pujari, S. S, additional, Rosenbaum, J. T, additional, Suhler, E. B, additional, and Thorne, J. E, additional

Published
2009
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30. Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy

Author

Chen, J., primary, Ruczinski, I., additional, Jorgensen, T. J., additional, Yenokyan, G., additional, Yao, Y., additional, Alani, R., additional, Liegeois, N. J., additional, Hoffman, S. C., additional, Hoffman-Bolton, J., additional, Strickland, P. T., additional, Helzlsouer, K. J., additional, and Alberg, A. J., additional

Published
2008
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37. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies

Author

Laden, F., primary, Collman, G., additional, Iwamoto, K., additional, Alberg, A. J., additional, Berkowitz, G. S., additional, Freudenheim, J. L., additional, Hankinson, S. E., additional, Helzlsouer, K. J., additional, Holford, T. R., additional, Huang, H.-Y., additional, Moysich, K. B., additional, Tessari, J. D., additional, Wolff, M. S., additional, Zheng, T., additional, and Hunter, D. J., additional

Published
2001
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43. Protective Alterations in Phase 1 and 2 Metabolism of Aflatoxin B1 by Oltipraz in Residents of Qidong, People's Republic of China

Author

Wang, J.-S., primary, Shen, X., additional, He, X., additional, Zhu, Y.-R., additional, Zhang, B.-C., additional, Wang, J.-B., additional, Qian, G.-S., additional, Kuang, S.-Y., additional, Zarba, A., additional, Egner, P. A., additional, Jacobson, L. P., additional, Munoz, A., additional, Helzlsouer, K. J., additional, Groopman, J. D., additional, and Kensler, T. W., additional

Published
1999
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48. Authors' reply

Author

Parkes, C., primary, Wald, N. J, additional, Murphy, P., additional, George, L., additional, Watt, H. C, additional, Kirby, R., additional, Knekt, P., additional, Helzlsouer, K J, additional, and Tuomilehto, J, additional

Published
1996
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