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Your search keyword '"Helseth, Ragnhild"' showing total 47 results
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47 results on '"Helseth, Ragnhild"'

1. Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size

Author

Kindberg, Kristine Mørk, Broch, Kaspar, Andersen, Geir Øystein, Anstensrud, Anne Kristine, Åkra, Sissel, Woxholt, Sindre, Tøllefsen, Ingvild Maria, Ueland, Thor, Amundsen, Brage Høyem, Kløw, Nils-Einar, Halvorsen, Bente, Dahl, Tuva B., Huse, Camilla, Murphy, Sarah Louise, Damås, Jan Kristian, Opdahl, Anders, Wiseth, Rune, Gullestad, Lars, Aukrust, Pål, Santos-Gallego, Carlos, Seljeflot, Ingebjørg, Stokke, Mathis Korseberg, and Helseth, Ragnhild

Published
2024
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6. NEUTROPHIL EXTRACELLULAR TRAPS ARE INVERSELY RELATED TO MYOCARDIAL SALVAGE IN ST-ELEVATION MYOCARDIAL INFARCTION INDEPENDENT OF TOCILIZUMAB TREATMENT

Author

Kindberg, Kristine Mork, primary, Broch, Kaspar, additional, Andersen, Geir, additional, Anstensrud, Anne Kristine, additional, Aakra, Sissel, additional, Woxholt, Sindre, additional, Opdahl, Anders, additional, Wiseth, Rune, additional, Gullestad, Lars, additional, Aukrust, Pal, additional, Seljeflot, Ingebjorg, additional, and Helseth, Ragnhild, additional

Published
2023
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15. Additional file 5 of Gene expression of fibrinolytic markers in coronary thrombi

Author

Nordeng, Jostein, Solheim, Svein, Åkra, Sissel, Schandiz, Hossein, Hoffmann, Pavel, Roald, Borghild, Bendz, Bjørn, Arnesen, Harald, Helseth, Ragnhild, and Seljeflot, Ingebjørg

Subjects
sense organs
Abstract

Additional file 5: Supplementary Table 5. Shows changes in levels of circulating PAI-1 and gene expression in circulating leukocytes from time of PCI to Day 1.

Published
2022
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17. Additional file 1 of Gene expression of fibrinolytic markers in coronary thrombi

Author

Nordeng, Jostein, Solheim, Svein, Åkra, Sissel, Schandiz, Hossein, Hoffmann, Pavel, Roald, Borghild, Bendz, Bjørn, Arnesen, Harald, Helseth, Ragnhild, and Seljeflot, Ingebjørg

Abstract

Additional file 1: Supplementary Table 1. Displays characteristics of the different histological age stages used for classifying thrombi into different age stages.

Published
2022
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20. Additional file 4 of Gene expression of fibrinolytic markers in coronary thrombi

Author

Nordeng, Jostein, Solheim, Svein, Åkra, Sissel, Schandiz, Hossein, Hoffmann, Pavel, Roald, Borghild, Bendz, Bjørn, Arnesen, Harald, Helseth, Ragnhild, and Seljeflot, Ingebjørg

Abstract

Additional file 4: Supplementary Table 4. Displays correlations between circulating PAI-1 and corresponding genes expressed in thrombi and in circulating leukocytes.

Published
2022
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26. Impact of Preinjury Antithrombotic Therapy on 30–Day Mortality in Older Patients Hospitalized With Traumatic Brain Injury (TBI)

Author

Rønning, Pål, primary, Helseth, Eirik, additional, Skaansar, Ola, additional, Tverdal, Cathrine, additional, Andelic, Nada, additional, Bhatnagar, Rahul, additional, Melberg, Mathias, additional, Skaga, Nils Oddvar, additional, Aarhus, Mads, additional, Halvorsen, Sigrun, additional, and Helseth, Ragnhild, additional

Published
2021
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28. Additional file 1 of Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training

Author

Aune, Susanne Kristine, Byrkjeland, Rune, Solheim, Svein, Arnesen, Harald, Trøseid, Marius, Ayodeji Awoyemi, Seljeflot, Ingebjørg, and Helseth, Ragnhild

Abstract

Additional file 1: Table S1. Baseline correlations between markers of gut leakage and glucometabolic state are presented in this table.

Published
2021
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32. EFFECT OF A SINGLE DOSE OF THE INTERLEUKIN-6 RECEPTOR ANTAGONIST TOCILIZUMAB ON MARKERS OF NEUTROPHIL EXTRACELLULAR TRAPS IN PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION

Author

Helseth, Ragnhild, primary, Kleveland, Ola, additional, Ueland, Thor, additional, Wiseth, Rune, additional, Damaas, Jan Kristian, additional, Broch, Kaspar, additional, Michelsen, Annika Elisabet, additional, Bendz, Bjørn, additional, Gullestad, Lars, additional, Aukrust, Paal, additional, and Seljeflot, Ingebjoerg, additional

Published
2020
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33. MOESM2 of Glucose associated NETosis in patients with ST-elevation myocardial infarction: an observational study

Author

Helseth, Ragnhild, Knudsen, Eva, Eritsland, Jan, Opstad, Trine, Arnesen, Harald, Andersen, Geir, and IngebjøRg Seljeflot

Subjects
endocrine system diseases, nutritional and metabolic diseases
Abstract

Additional file 2: Table S2. dsDNA and MPO-DNA related to the glucometabolic status in the acute phase. Values are given as median (25, 75 pencentiles). p values are based on the Mann-Whitney U test. dsDNA: double-stranded deoxyribonucleic acid. IFG: impaired fasting glucose. IGT: impaired glucose tolerance. MPO-DNA: myeloperoxidase deoxyribonucleic acid. OD: optical density units. T2DM: type 2 diabetes mellitus. pa: NGR vs. IFG. pb: NGR vs. IGT. pc: NGR vs. T2DM.

Published
2019
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34. Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI

Author

Helseth, Ragnhild, primary, Shetelig, Christian, additional, Andersen, Geir Øystein, additional, Langseth, Miriam Sjåstad, additional, Limalanathan, Shanmuganathan, additional, Opstad, Trine B., additional, Arnesen, Harald, additional, Hoffmann, Pavel, additional, Eritsland, Jan, additional, and Seljeflot, Ingebjørg, additional

Published
2019
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36. The Time Profile of Pentraxin 3 in Patients with Acute ST-Elevation Myocardial Infarction and Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention

Author

Helseth, Ragnhild, Solheim, Svein, Opstad, Trine, Hoffmann, Pavel, Arnesen, Harald, and Seljeflot, Ingebjørg

Subjects
Adult, Male, Time Factors, Article Subject, Myocardial Infarction, Middle Aged, Magnetic Resonance Imaging, Angina Pectoris, Blood Cell Count, Serum Amyloid P-Component, C-Reactive Protein, Percutaneous Coronary Intervention, Gene Expression Regulation, Troponin T, Clinical Study, Leukocytes, lcsh:Pathology, Humans, Female, RNA, Messenger, cardiovascular diseases, Aged, lcsh:RB1-214
Abstract

Background. High levels of Pentraxin 3 (PTX3) are reported in acute myocardial infarction (AMI). Aim. To investigate circulating levels and gene expression of PTX3 in patients with AMI and stable angina pectoris (AP) undergoing PCI. Methods. Ten patients with AP and 20 patients with AMI were included. Blood samples were drawn before PCI in the AP group and after 3 and 12 hours and days 1, 3, 5, 7, and 14 in both groups. Results. Circulating PTX3 levels were higher in AMI compared to AP at 3 and 12 hours (P < 0.001 and P = 0.003). Within the AMI group, reduction from 3 hours to all later time points was observed (all P ≤ 0.001). Within the AP group, increase from baseline to 3 hours (P = 0.022), followed by reductions thereafter (all P < 0.05), was observed. PTX3 mRNA increased in the AMI group from 3 hours to days 7 and 14 in a relative manner of 62% and 73%, while a relative reduction from baseline to 3 and 12 hours of 29% and 37% was seen in the AP group. Conclusion. High circulating PTX3 levels shortly after PCI in AMI indicate that AMI itself influences PTX3 levels. PTX3 mRNA might be in response to fluctuations in circulating levels.

Published
2014

39. Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction

Author

Helseth, Ragnhild, Weiss, Thomas W., Opstad, Trine Baur, Siegbahn, Agneta, Solheim, Svein, Freynhofer, Matthias K., Huber, Kurt, Arnesen, Harald, Seljeflot, Seljeflot, Helseth, Ragnhild, Weiss, Thomas W., Opstad, Trine Baur, Siegbahn, Agneta, Solheim, Svein, Freynhofer, Matthias K., Huber, Kurt, Arnesen, Harald, and Seljeflot, Seljeflot

Abstract

Introduction: Several genes are expressed in aspirated coronary thrombi in acute myocardial infarction (AMI), exhibiting dynamic changes along ischemic time. Whether soluble biomarkers reflect the local gene environment and ischemic time is unclear. We explored whether circulating biomarkers were associated with corresponding coronary thrombi genes and total ischemic time. Material and methods: In 33 AMI patients undergoing percutaneous coronary intervention (PCI), blood samples were collected within 6-24 h for markers related to plaque rupture (metalloproteinase 9, tissue inhibitor of metalloproteinases 1), platelet and endothelial cell activation (P-selectin, CD40 ligand, PAR-1), hemostasis (tissue factor, tissue plasminogen activator, plasminogen activator inhibitor 1, free and total tissue factor pathway inhibitor, D-dimer, prothrombin fragment 1 + 2), inflammation (interleukin 8 and 18, fractalkine, monocyte chemoattractant protein 1 (MCP-1), CXCL1, pentraxin 3, myeloperoxidase) and galectin 3, caspase 8 and epidermal growth factor (EGF). Laboratory analyses were performed by Proximity Extension Assay (Proseek Multiplex CVD I-96 (x 96)), ELISAs and RT-PCR. Results: Only circulating P-selectin correlated to the corresponding P-selectin gene expression in thrombi (r = 0.530, p = 0.002). Plasma galectin 3, fractalkine, MCP-1 and caspase 8 correlated inversely to ischemic time (r = -0.38-0.50, all p < 0.05), while plasma MCP-1, galectin 3 and EGF were higher at short (<= 4 h) vs. long (>4 h) ischemic time (all p < 0.05). Conclusions: The dynamic changes in circulating mediators along ischemic time were not reflected in the profile of locally expressed genes. These observations indicate a locally confined milieu within the site of atherothrombosis, which may be important for selective therapy.

Published
2015
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47. Androgens and hyperemesis gravidarum: a case-control study.

Author

Helseth R, Ravlo M, Carlsen SM, and Vanky EE

Subjects
Adult, Case-Control Studies, Female, Humans, Linear Models, Pregnancy, Young Adult, Androgens blood, Hyperemesis Gravidarum blood
Abstract

Objective: The pathogenesis of hyperemesis gravidarum (HG) is probably multifactorial, involving several hormones. Androgen concentrations are reported to correlate positively with emesis gravidarum. Hypothesizing a continuum between emesis gravidarum and HG, we investigated androgen concentrations in women with HG., Study Design: In a case-control study, 32 women hospitalized for HG were compared with 29 control women scheduled for elective surgical abortion. Control women were matched for age, gestational length, body mass index (BMI) and parity. Patient characteristics and concentrations of dehydroepiandrosterone sulphate (DHEAS), androstenedione, testosterone, sex hormone binding globulin (SHBG), free testosterone index (FTI), androstanediol glucuronide (ADG), progesterone, TSH, free T3 and T4, beta-hCG, ferritin, insulin, estradiol and estriol were compared using Mann-Whitney tests and multivariate linear regression analyses., Results: Women with HG had higher concentrations of ADG (8.49±4.19 vs. 6.19±1.77pmol/L; p=0.015), estradiol (2.39±1.36 vs. 1.60±9.30nmol/L; p=0.009) and ferritin (186±138 vs. 117±94pmol/L; p=0.040) compared with control women. Androstenedione (5.34±2.82 vs. 6.86±2.67; p=0.004) and insulin (63.7±35.0 vs. 75.3±25.8; p=0.050) concentrations were lower in women with HG. DHEAS, testosterone, FTI, SHBG, estriol, progesterone, beta-hCG, TSH, free T3 and free T4 concentrations did not differ between the groups. In multivariate regression analyses HG was associated with high concentrations of ADG (p=0.026) and low concentrations of androstenedione (p=0.018)., Conclusion: Steroid hormone homeostasis may be altered in women with HG. HG may be associated with high ADG and low androstenedione concentrations., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Published
2014
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