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10 results on '"Helsel, Carmen"'

1. Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Author

Network, The Cancer Genome Atlas Research, Abeshouse, Adam, Adebamowo, Clement, Adebamowo, Sally N, Akbani, Rehan, Akeredolu, Teniola, Ally, Adrian, Anderson, Matthew L, Anur, Pavana, Appelbaum, Elizabeth L, Armenia, Joshua, Auman, J Todd, Bailey, Matthew H, Baker, Laurence, Balasundaram, Miruna, Balu, Saianand, Barthel, Floris P, Bartlett, John, Baylin, Stephen B, Behera, Madhusmita, Belyaev, Dmitry, Bennett, Joesph, Benz, Christopher, Beroukhim, Rameen, Birrer, Michael, Bocklage, Thèrése, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S, Bowen, Jay, Bowlby, Reanne, Boyd, Jeff, Brohl, Andrew S, Brooks, Denise, Byers, Lauren, Carlsen, Rebecca, Castro, Patricia, Chen, Hsiao-Wei, Cherniack, Andrew D, Chibon, Fréderic, Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cibulskis, Carrie, Cooper, Lee AD, Cope, Leslie, Cordes, Matthew G, Crain, Daniel, Curley, Erin, Danilova, Ludmila, Dao, Fanny, Davis, Ian J, Davis, Lara E, Defreitas, Timothy, Delman, Keith, Demchok, John A, Demetri, George D, Demicco, Elizabeth G, Dhalla, Noreen, Diao, Lixia, Ding, Li, DiSaia, Phil, Dottino, Peter, Doyle, Leona A, Drill, Esther, Dubina, Michael, Eschbacher, Jennifer, Fedosenko, Konstantin, Felau, Ina, Ferguson, Martin L, Frazer, Scott, Fronick, Catrina C, Fulidou, Victoria, Fulton, Lucinda A, Fulton, Robert S, Gabriel, Stacey B, Gao, Jianjiong, Gao, Qingsong, Gardner, Johanna, Gastier-Foster, Julie M, Gay, Carl M, Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Godwin, Andrew K, Godwin, Eryn M, Gordienko, Elena, Grilley-Olson, Juneko E, Gutman, David A, Gutmann, David H, Hayes, D Neil, Hegde, Apurva M, Heiman, David I, Heins, Zachary, Helsel, Carmen, Hepperla, Austin J, Higgins, Kelly, Hoadley, Katherine A, and Hobensack, Shital

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Cancer, Human Genome, Digestive Diseases, Rare Diseases, Adult, Aged, Aged, 80 and over, Cluster Analysis, DNA Copy Number Variations, Epigenomics, Genome, Human, Genome-Wide Association Study, Humans, Middle Aged, Mutation, Sarcoma, Young Adult, Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca, Cancer Genome Atlas Research Network, DNA methylation, The Cancer Genome Atlas, dedifferentiated liposarcoma, genomics, immune infiltration, leiomyosarcoma, molecular subtype, myxofibrosarcoma, pleomorphism, undifferentiated pleomorphic sarcoma, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types.

Published
2017

2. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Author

Robertson, A Gordon, Shih, Juliann, Yau, Christina, Gibb, Ewan A, Oba, Junna, Mungall, Karen L, Hess, Julian M, Uzunangelov, Vladislav, Walter, Vonn, Danilova, Ludmila, Lichtenberg, Tara M, Kucherlapati, Melanie, Kimes, Patrick K, Tang, Ming, Penson, Alexander, Babur, Ozgun, Akbani, Rehan, Bristow, Christopher A, Hoadley, Katherine A, Iype, Lisa, Chang, Matthew T, Network, TCGA Research, Abdel-Rahman, Mohamed H, Ally, Adrian, Auman, J Todd, Balasundaram, Miruna, Balu, Saianand, Benz, Christopher, Beroukhim, Rameen, Birol, Inanc, Bodenheimer, Tom, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Cebulla, Colleen M, Cherniack, Andrew D, Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cibulskis, Carrie, Cibulskis, Kristian, Cope, Leslie, Coupland, Sarah E, Defreitas, Timothy, Demchok, John A, Desjardins, Laurence, Dhalla, Noreen, Esmaeli, Bita, Felau, Ina, Ferguson, Martin L, Frazer, Scott, Gabriel, Stacey B, Gastier-Foster, Julie M, Gehlenborg, Nils, Gerken, Mark, Gershenwald, Jeffrey E, Getz, Gad, Griewank, Klaus G, Grimm, Elizabeth A, Hayes, D Neil, Hegde, Apurva M, Heiman, David I, Helsel, Carmen, Hobensack, Shital, Holt, Robert A, Hoyle, Alan P, Hu, Xin, Hutter, Carolyn M, Jager, Martine J, Jefferys, Stuart R, Jones, Corbin D, Jones, Steven JM, Kandoth, Cyriac, Kasaian, Katayoon, Kim, Jaegil, Kucherlapati, Raju, Lander, Eric, Lawrence, Michael S, Lazar, Alexander J, Lee, Semin, Leraas, Kristen M, Lin, Pei, Liu, Jia, Liu, Wenbin, Lolla, Laxmi, and Lu, Yiling

Subjects
Eye Disease and Disorders of Vision, Cancer, Human Genome, Rare Diseases, Genetics, Biomarkers, Tumor, DNA Copy Number Variations, DNA Methylation, Eukaryotic Initiation Factor-1, Gene Expression Regulation, Neoplastic, Humans, Melanoma, Monosomy, Mutation, Phosphoproteins, Prognosis, RNA Splicing Factors, Serine-Arginine Splicing Factors, Tumor Suppressor Proteins, Ubiquitin Thiolesterase, Uveal Neoplasms, TCGA Research Network, EIF1AX, GNA11, GNAQ, SF3B1, SRSF2, TCGA, molecular subtypes, monosomy 3, noncoding RNA, uveal melanoma, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. We report change-of-function SRSF2 mutations. Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes.

Published
2017

3. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Author

Ally, Adrian, Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Clarke, Amanda, Dhalla, Noreen, Holt, Robert A, Jones, Steven JM, Lee, Darlene, Ma, Yussanne, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Andrew J, Schein, Jacqueline E, Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Cheung, Dorothy, Wong, Tina, Brooks, Denise, Robertson, A Gordon, Bowlby, Reanne, Mungall, Karen, Sadeghi, Sara, Xi, Liu, Covington, Kyle, Shinbrot, Eve, Wheeler, David A, Gibbs, Richard A, Donehower, Lawrence A, Wang, Linghua, Bowen, Jay, Gastier-Foster, Julie M, Gerken, Mark, Helsel, Carmen, Leraas, Kristen M, Lichtenberg, Tara M, Ramirez, Nilsa C, Wise, Lisa, Zmuda, Erik, Gabriel, Stacey B, Meyerson, Matthew, Cibulskis, Carrie, Murray, Bradley A, Shih, Juliann, Beroukhim, Rameen, Cherniack, Andrew D, Schumacher, Steven E, Saksena, Gordon, Pedamallu, Chandra Sekhar, Chin, Lynda, Getz, Gad, Noble, Michael, Zhang, Hailei, Heiman, David, Cho, Juok, Gehlenborg, Nils, Voet, Douglas, Lin, Pei, Frazer, Scott, Defreitas, Timothy, Meier, Sam, Lawrence, Michael, Kim, Jaegil, Creighton, Chad J, Muzny, Donna, Doddapaneni, HarshaVardhan, Hu, Jianhong, Wang, Min, Morton, Donna, Korchina, Viktoriya, Han, Yi, Dinh, Huyen, Lewis, Lora, Bellair, Michelle, Liu, Xiuping, Santibanez, Jireh, Glenn, Robert, Lee, Sandra, Hale, Walker, Parker, Joel S, Wilkerson, Matthew D, Hayes, D Neil, Reynolds, Sheila M, Shmulevich, Ilya, Zhang, Wei, Liu, Yuexin, Iype, Lisa, Makhlouf, Hala, Torbenson, Michael S, Kakar, Sanjay, Yeh, Matthew M, Jain, Dhanpat, Kleiner, David E, Dhanasekaran, Renumathy, El-Serag, Hashem B, and Yim, Sun Young

Subjects
Human Genome, Digestive Diseases, Biotechnology, Rare Diseases, Genetics, Liver Disease, Liver Cancer, Cancer, Aetiology, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Carcinoma, Hepatocellular, DNA Methylation, Genomics, Humans, Isocitrate Dehydrogenase, Liver Neoplasms, MicroRNAs, Mutation, Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, Cancer Genome Atlas Research Network, IDH1/2, TP53, cancer subtyping, expression profile, hepatocellular carcinoma, metabolic reprogramming, promoter hypermethylation, significantly mutated genes, sonic hedgehog signaling, stem cell phenotype, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, and SMARCA4. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APOB, and CPS1) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts. Integrated analyses enabled development of a p53 target gene expression signature correlating with poor survival. Potential therapeutic targets for which inhibitors exist include WNT signaling, MDM4, MET, VEGFA, MCL1, IDH1, TERT, and immune checkpoint proteins CTLA-4, PD-1, and PD-L1.

Published
2017

4. Comprehensive molecular characterization of gastric adenocarcinoma

Author

Bass, Adam J., Thorsson, Vesteinn, Shmulevich, Ilya, Reynolds, Sheila M., Miller, Michael, Bernard, Brady, Hinoue, Toshinori, Laird, Peter W., Curtis, Christina, Shen, Hui, Weisenberger, Daniel J., Schultz, Nikolaus, Shen, Ronglai, Weinhold, Nils, Kelsen, David P., Bowlby, Reanne, Chu, Andy, Kasaian, Katayoon, Mungall, Andrew J., Robertson, Gordon A., Sipahimalani, Payal, Cherniack, Andrew, Getz, Gad, Liu, Yingchun, Noble, Michael S., Pedamallu, Chandra, Sougnez, Carrie, Akbani, Rehan, Lee, Ju-Seog, Liu, Wenbin, Mills, Gordon B., Yang, Da, Zhang, Wei, Pantazi, Angeliki, Gulley, Margaret, Piazuelo, Blanca M., Schneider, Barbara G., Kim, Jihun, Boussioutas, Alex, Sheth, Margi, Demchok, John A., Rabkin, Charles S., Willis, Joseph E., Ng, Sam, Garman, Katherine, Beer, David G., Pennathur, Arjun, Raphael, Benjamin J., Wu, Hsin-Ta, Odze, Robert, Kim, Hark K., Bowen, Jay, Leraas, Kristen M., Lichtenberg, Tara M., Weaver, Stephanie, McLellan, Michael, Wiznerowicz, Maciej, Sakai, Ryo, Lawrence, Michael S., Cibulskis, Kristian, Lichtenstein, Lee, Fisher, Sheila, Gabriel, Stacey B., Lander, Eric S., Ding, Li, Niu, Beifang, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Brooks, Denise, Butterfield, Yaron S. N., Carlsen, Rebecca, Chu, Justin, Chuah, Eric, Chun, Hye-Jung E., Clarke, Amanda, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A., Jones, Steven J. M., Lee, Darlene, Li, Haiyan A., Lim, Emilia, Ma, Yussanne, Marra, Marco A., Mayo, Michael, Moore, Richard A., Mungall, Karen L., Nip, Ka Ming, Schein, Jacqueline E., Tam, Angela, Thiessen, Nina, Beroukhim, Rameen, Carter, Scott L., Cherniack, Andrew D., Cho, Juok, DiCara, Daniel, Frazer, Scott, Gehlenborg, Nils, Heiman, David I., Jung, Joonil, Kim, Jaegil, Lin, Pei, Meyerson, Matthew, Ojesina, Akinyemi I., Pedamallu, Chandra Sekhar, Saksena, Gordon, Schumacher, Steven E., Stojanov, Petar, Tabak, Barbara, Voet, Doug, Rosenberg, Mara, Zack, Travis I., Zhang, Hailei, Zou, Lihua, Protopopov, Alexei, Santoso, Netty, Parfenov, Michael, Lee, Semin, Zhang, Jianhua, Mahadeshwar, Harshad S., Tang, Jiabin, Ren, Xiaojia, Seth, Sahil, Yang, Lixing, Xu, Andrew W., Song, Xingzhi, Xi, Ruibin, Bristow, Christopher A., Hadjipanayis, Angela, Seidman, Jonathan, Chin, Lynda, Park, Peter J., Kucherlapati, Raju, Ling, Shiyun, Rao, Arvind, Weinstein, John N., Kim, Sang-Bae, Lu, Yiling, Mills, Gordon, Bootwalla, Moiz S., Lai, Phillip H., Triche, Timothy, Jr, Van Den Berg, David J., Baylin, Stephen B., Herman, James G., Murray, Bradley A., Askoy, Arman B., Ciriello, Giovanni, Dresdner, Gideon, Gao, Jianjiong, Gross, Benjamin, Jacobsen, Anders, Lee, William, Ramirez, Ricardo, Sander, Chris, Senbabaoglu, Yasin, Sinha, Rileen, Sumer, Onur S., Sun, Yichao, Thorsson, Vésteinn, Iype, Lisa, Kramer, Roger W., Kreisberg, Richard, Rovira, Hector, Tasman, Natalie, Haussler, David, Stuart, Josh M., Verhaak, Roeland G. W., Leiserson, Mark D. M., Taylor, Barry S., Black, Aaron D., Carney, Julie Ann, Gastier-Foster, Julie M., Helsel, Carmen, McAllister, Cynthia, Ramirez, Nilsa C., Tabler, Teresa R., Wise, Lisa, Zmuda, Erik, Penny, Robert, Crain, Daniel, Gardner, Johanna, Lau, Kevin, Curely, Erin, Mallery, David, Morris, Scott, Paulauskis, Joseph, Shelton, Troy, Shelton, Candace, Sherman, Mark, Benz, Christopher, Lee, Jae-Hyuk, Fedosenko, Konstantin, Manikhas, Georgy, Potapova, Olga, Voronina, Olga, Belyaev, Dmitry, Dolzhansky, Oleg, Rathmell, Kimryn W., Brzezinski, Jakub, Ibbs, Matthew, Korski, Konstanty, Kycler, Witold, Łaźniak, Radoslaw, Leporowska, Ewa, Mackiewicz, Andrzej, Murawa, Dawid, Murawa, Pawel, Spychała, Arkadiusz, Suchorska, Wiktoria M., Tatka, Honorata, Teresiak, Marek, Abdel-Misih, Raafat, Bennett, Joseph, Brown, Jennifer, Iacocca, Mary, Rabeno, Brenda, Kwon, Sun-Young, Kemkes, Ariane, Curley, Erin, Alexopoulou, Iakovina, Engel, Jay, Bartlett, John, Albert, Monique, Park, Do-Youn, Dhir, Rajiv, Luketich, James, Landreneau, Rodney, Janjigian, Yelena Y., Cho, Eunjung, Ladanyi, Marc, Tang, Laura, McCall, Shannon J., Park, Young S., Cheong, Jae-Ho, Ajani, Jaffer, Camargo, Constanza M., Alonso, Shelley, Ayala, Brenda, Jensen, Mark A., Pihl, Todd, Raman, Rohini, Walton, Jessica, Wan, Yunhu, Eley, Greg, Mills Shaw, Kenna R., Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean Claude, Davidsen, Tanja, Hutter, Carolyn M., Sofia, Heidi J., Burton, Robert, Chudamani, Sudha, and Liu, Jia

Published
2014
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5. Comprehensive molecular characterization of urothelial bladder carcinoma

Author

Weinstein, John N., Akbani, Rehan, Broom, Bradley M., Wang, Wenyi, Verhaak, Roeland G. W., McConkey, David, Lerner, Seth, Morgan, Margaret, Creighton, Chad J., Smith, Carolyn, Kwiatkowski, David J., Cherniack, Andrew D., Kim, Jaegil, Pedamallu, Chandra Sekhar, Noble, Michael S., Al-Ahmadie, Hikmat A., Reuter, Victor E., Rosenberg, Jonathan E., Bajorin, Dean F., Bochner, Bernard H., Solit, David B., Koppie, Theresa, Robinson, Brian, Gordenin, Dmitry A., Fargo, David, Klimczak, Leszek J., Roberts, Steven A., Au, Jessie, Laird, Peter W., Hinoue, Toshinori, Schultz, Nikolaus, Ramirez, Ricardo, Hansel, Donna, Hoadley, Katherine A., Kim, William Y., Damrauer, Jeffrey S., Baylin, Stephen B., Mungall, Andrew J., Robertson, Gordon A., Chu., Andy, Sougnez, Carrie, Cibulskis, Kristian, Lichtenstein, Lee, Sivachenko, Andrey, Stewart, Chip, Lawrence, Michael S., Getz, Gad, Lander, Eric, Gabriel., Stacey B., Donehower, Lawrence, Carter, Scott L., Saksena, Gordon, Schumacher, Steven E., Freeman, Samuel S., Jung, Joonil, Bhatt, Ami S., Pugh, Trevor, Beroukhim, Rameen, Gabriel, Stacey B., Meyerson, Matthew, Chu, Andy, Ally, Adrian, Balasundaram, Miruna, Butterfield, Yaron S. N., Dhalla, Noreen, Hirst, Carrie, Holt, Robert A., Jones, Steven J. M., Lee, Darlene, Li, Haiyan I., Marra, Marco A., Mayo, Michael, Moore, Richard A., Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Wye, Natasja, Bowlby, Reanne, Chuah, Eric, Guin, Ranabir, Shen, Hui, Bootwalla, Moiz S., Jr, Timothy Triche, Lai, Phillip H., Van Den Berg, David J., Weisenberger, Daniel J., Balu, Saianand, Bodenheimer, Tom, Damrauer Alan P. Hoyle, Jeffrey S., Jefferys, Stuart R., Meng, Shaowu, Mose, Lisle E., Simons, Janae V., Soloway, Mathew G., Wu, Junyuan, Parker, Joel S., Hayes, Neil D., Roach, Jeffrey, Buda, Elizabeth, Jones, Corbin D., Mieczkowski, Piotr A., Tan, Donghui, Veluvolu, Umadevi, Waring, Scot, Auman, Todd J., Perou, Charles M., Wilkerson, Matthew D., Santoso, Netty, Parfenov, Michael, Ren, Xiaojia, Pantazi, Angeliki, Hadjipanayis, Angela, Seidman, Jonathan, Kucherlapati, Raju, Lee, Semin, Yang, Lixing, Park, Peter J., Xu, Andrew Wei, Protopopov, Alexei, Zhang, Jianhua, Bristow, Christopher, Mahadeshwar, Harshad S., Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Zeng, Dong, Chin, Lynda, Guo, Charles, Casasent, Tod D., Liu, Wenbin, Ju, Zhenlin, Motter, Thomas, Peng, Bo, Ryan, Michael, Su, Xiaoping, Yang, Ji-Yeon, Lorenzi, Philip L., Yao, Hui, Zhang, Nianxiang, Zhang, Jiexin, Mills, Gordon B., Cho, Juok, DiCara, Daniel, Frazer, Scott, Gehlenborg, Nils, Heiman, David I., Lin, Pei, Liu, Yingchun, Stojanov, Petar, Voet, Doug, Zhang, Hailei, Zou, Lihua, Bernard, Brady, Kreisberg, Dick, Reynolds, Sheila, Rovira, Hector, Shmulevich, Ilya, Gao, Jianjiong, Jacobsen, Anders, Aksoy, Arman B., Antipin, Yevgeniy, Ciriello, Giovanni, Dresdner, Gideon, Gross, Benjamin, Lee, William, Reva, Boris, Shen, Ronglai, Sinha, Rileen, Sumer, Onur S., Weinhold, Nils, Ladanyi, Marc, Sander, Chris, Benz, Christopher, Carlin, Daniel, Haussler, David, Ng, Sam, Paull, Evan O., Stuart, Joshua, Zhu, Jing, Liu, Yuexin, Zhang, Wei, Taylor, Barry S., Lichtenberg, Tara M., Zmuda, Erik, Barr, Thomas, Black, Aaron D., George, Myra, Hanf, Benjamin, Helsel, Carmen, McAllister, Cynthia, Ramirez, Nilsa C., Tabler, Teresa R., Weaver, Stephanie, Wise, Lisa, Bowen, Jay, Gastier-Foster, Julie M., Jian, Weiguo, Tello, Sebrina, Ittman, Michael, Castro, Patricia, McClenden, Whitney D., Gibbs, Richard, Saller, Charles, Tarvin, Katherine, DiPiero, Jennifer M., Owens, Jennifer, Bollag, Roni, Li, Qiang, Weinberger, Paul, Czerwinski, Christine, Huelsenbeck-Dill, Lori, Iacocca, Mary, Petrelli, Nicholas, Rabeno, Brenda, Swanson, Pat, Shelton, Troy, Curley, Erin, Gardner, Johanna, Mallery, David, Penny, Robert, Van Bang, Nguyen, Thi Hanh, Phan, Kohl, Bernard, Van Le, Xuan, Duc Phu, Bui, Thorp, Richard, Tien, Nguyen Viet, Vinh, Le Quang, Sandusky, George, Burks, Eric, Christ, Kimberly, Gee, Jason, Holway, Antonia, Moinzadeh, Alireza, Sorcini, Andrea, Sullivan, Travis, Garcia-Grossman, Ilana R., Regazzi, Ashley M., Boice, Lori, Rathmell, Wendy Kimryn, Thorne, Leigh, Bastacky, Sheldon, Davies, Benjamin, Dhir, Rajiv, Gingrich, Jeffrey, Hrebinko, Ronald, Maranchie, Jodi, Nelson, Joel, Parwani, Anil, Bshara, Wiam, Gaudioso, Carmelo, Morrison, Carl, Alexopoulou, Vina, Bartlett, John, Engel, Jay, Kodeeswaran, Sugy, Antic, Tatjana, O’Donnell, Peter H., Smith, Norm D., Steinberg, Gary D., Egea, Sophie, Gomez-Fernandez, Carmen, Herbert, Lynn, Jorda, Merce, Soloway, Mark, Beaver, Allison, Carter, Suzie, Kapur, Payal, Lewis, Cheryl, Lotan, Yair, Bondaruk, Jolanta, Czerniak, Bogdan, Skinner, Eila, Aldape, Kenneth, Jensen, Mark A., Kahn, Ari B., Pihl, Todd D., Pot, David A., Srinivasan, Deepak, Wan, Yunhu, Ferguson, Martin L., Zenklusen, Jean Claude, Davidsen, Tanja, Demchok, John A., Mills Shaw, Kenna R., Sheth, Margi, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Hutter, Carolyn, Ozenberger, Bradley A., Sofia, Heidi J., and Eley, Greg

Published
2014
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6. Integrated genomic characterization of endometrial carcinoma

Author

Getz, Gad, Gabriel, Stacey B., Cibulskis, Kristian, Lander, Eric, Sivachenko, Andrey, Sougnez, Carrie, Lawrence, Mike, Kandoth, Cyriac, Dooling, David, Fulton, Robert, Fulton, Lucinda, Kalicki-Veizer, Joelle, McLellan, Michael D., OʼLaughlin, Michelle, Schmidt, Heather, Wilson, Richard K., Ye, Kai, Ding, Li, Mardis, Elaine R., Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron S. N., Carlsen, Rebecca, Carter, Candace, Chu, Andy, Chuah, Eric, Chun, Hye-Jung E., Dhalla, Noreen, Guin, Ranabir, Hirst, Carrie, Holt, Robert A., Jones, Steven J. M., Lee, Darlene, Li, Haiyan I., Marra, Marco A., Mayo, Michael, Moore, Richard A., Mungall, Andrew J., Plettner, Patrick, Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Varhol, Richard J., Gordon Robertson, A., Cherniack, Andrew D., Pashtan, Itai, Saksena, Gordon, Onofrio, Robert C., Schumacher, Steven E., Tabak, Barbara, Carter, Scott L., Hernandez, Bryan, Gentry, Jeff, Salvesen, Helga B., Ardlie, Kristin, Winckler, Wendy, Beroukhim, Rameen, Meyerson, Matthew, Hadjipanayis, Angela, Lee, Semin, Mahadeshwar, Harshad S., Park, Peter, Protopopov, Alexei, Ren, Xiaojia, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Xi, Ruibin, Yang, Lixing, Zeng, Dong, Kucherlapati, Raju, Chin, Lynda, Zhang, Jianhua, Todd Auman, J., Balu, Saianand, Bodenheimer, Tom, Buda, Elizabeth, Neil Hayes, D., Hoyle, Alan P., Jefferys, Stuart R., Jones, Corbin D., Meng, Shaowu, Mieczkowski, Piotr A., Mose, Lisle E., Parker, Joel S., Perou, Charles M., Roach, Jeff, Shi, Yan, Simons, Janae V., Soloway, Mathew G., Tan, Donghui, Topal, Michael D., Waring, Scot, Wu, Junyuan, Hoadley, Katherine A., Baylin, Stephen B., Bootwalla, Moiz S., Lai, Phillip H., Triche, Timothy J., Jr, Van Den Berg, David J., Weisenberger, Daniel J., Laird, Peter W., Shen, Hui, Cho, Juok, DiCara, Daniel, Frazer, Scott, Heiman, David, Jing, Rui, Lin, Pei, Mallard, Will, Stojanov, Petar, Voet, Doug, Zhang, Hailei, Zou, Lihua, Noble, Michael, Reynolds, Sheila M., Shmulevich, Ilya, Arman Aksoy, B., Antipin, Yevgeniy, Ciriello, Giovanni, Dresdner, Gideon, Gao, Jianjiong, Gross, Benjamin, Jacobsen, Anders, Ladanyi, Marc, Reva, Boris, Sander, Chris, Sinha, Rileen, Onur Sumer, S., Taylor, Barry S., Cerami, Ethan, Weinhold, Nils, Schultz, Nikolaus, Shen, Ronglai, Benz, Stephen, Goldstein, Ted, Haussler, David, Ng, Sam, Szeto, Christopher, Stuart, Joshua, Benz, Christopher C., Yau, Christina, Zhang, Wei, Annala, Matti, Broom, Bradley M., Casasent, Tod D., Ju, Zhenlin, Liang, Han, Liu, Guoyan, Lu, Yiling, Unruh, Anna K., Wakefield, Chris, Weinstein, John N., Zhang, Nianxiang, Liu, Yuexin, Broaddus, Russell, Akbani, Rehan, Mills, Gordon B., Adams, Christopher, Barr, Thomas, Black, Aaron D., Bowen, Jay, Deardurff, John, Frick, Jessica, Gastier-Foster, Julie M., Grossman, Thomas, Harper, Hollie A., Hart-Kothari, Melissa, Helsel, Carmen, Hobensack, Aaron, Kuck, Harkness, Kneile, Kelley, Leraas, Kristen M., Lichtenberg, Tara M., McAllister, Cynthia, Pyatt, Robert E., Ramirez, Nilsa C., Tabler, Teresa R., Vanhoose, Nathan, White, Peter, Wise, Lisa, Zmuda, Erik, Barnabas, Nandita, Berry-Green, Charlenia, Blanc, Victoria, Boice, Lori, Button, Michael, Farkas, Adam, Green, Alex, MacKenzie, Jean, Nicholson, Dana, Kalloger, Steve E., Blake Gilks, C., Karlan, Beth Y., Lester, Jenny, Orsulic, Sandra, Borowsky, Mark, Cadungog, Mark, Czerwinski, Christine, Huelsenbeck-Dill, Lori, Iacocca, Mary, Petrelli, Nicholas, Rabeno, Brenda, Witkin, Gary, Nemirovich-Danchenko, Elena, Potapova, Olga, Rotin, Daniil, Berchuck, Andrew, Birrer, Michael, DiSaia, Phillip, Monovich, Laura, Curley, Erin, Gardner, Johanna, Mallery, David, Penny, Robert, Dowdy, Sean C., Winterhoff, Boris, Dao, Linda, Gostout, Bobbie, Meuter, Alexandra, Teoman, Attila, Dao, Fanny, Olvera, Narciso, Bogomolniy, Faina, Garg, Karuna, Soslow, Robert A., Levine, Douglas A., Abramov, Mikhail, Bartlett, John M. S., Kodeeswaran, Sugy, Parfitt, Jeremy, Moiseenko, Fedor, Clarke, Blaise A., Goodman, Marc T., Carney, Michael E., Matsuno, Rayna K., Fisher, Jennifer, Huang, Mei, Kimryn Rathmell, W., Thorne, Leigh, Van Le, Linda, Dhir, Rajiv, Edwards, Robert, Elishaev, Esther, Zorn, Kristin, Goodfellow, Paul J., Mutch, David, Kahn, Ari B., Bell, Daphne W., Pollock, Pamela M., Wang, Chen, A.Wheeler, David, Shinbrot, Eve, Ayala, Brenda, Chu, Anna L., Jensen, Mark A., Kothiyal, Prachi, Pihl, Todd D., Pontius, Joan, Pot, David A., Snyder, Eric E., Srinivasan, Deepak, Mills Shaw, Kenna R., Sheth, Margi, Davidsen, Tanja, Eley Martin L. Ferguson, Greg, Demchok, John A., Yang, Liming, Guyer, Mark S., Ozenberger, Bradley A., and Sofia, Heidi J.

Published
2013
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7. Integrated Molecular Characterization of Testicular Germ Cell Tumors

Author

Shen, Hui, primary, Shih, Juliann, additional, Hollern, Daniel P., additional, Wang, Linghua, additional, Bowlby, Reanne, additional, Tickoo, Satish K., additional, Thorsson, Vésteinn, additional, Mungall, Andrew J., additional, Newton, Yulia, additional, Hegde, Apurva M., additional, Armenia, Joshua, additional, Sánchez-Vega, Francisco, additional, Pluta, John, additional, Pyle, Louise C., additional, Mehra, Rohit, additional, Reuter, Victor E., additional, Godoy, Guilherme, additional, Jones, Jeffrey, additional, Shelley, Carl S., additional, Feldman, Darren R., additional, Vidal, Daniel O., additional, Lessel, Davor, additional, Kulis, Tomislav, additional, Cárcano, Flavio M., additional, Leraas, Kristen M., additional, Lichtenberg, Tara M., additional, Brooks, Denise, additional, Cherniack, Andrew D., additional, Cho, Juok, additional, Heiman, David I., additional, Kasaian, Katayoon, additional, Liu, Minwei, additional, Noble, Michael S., additional, Xi, Liu, additional, Zhang, Hailei, additional, Zhou, Wanding, additional, ZenKlusen, Jean C., additional, Hutter, Carolyn M., additional, Felau, Ina, additional, Zhang, Jiashan, additional, Schultz, Nikolaus, additional, Getz, Gad, additional, Meyerson, Matthew, additional, Stuart, Joshua M., additional, Akbani, Rehan, additional, Wheeler, David A., additional, Laird, Peter W., additional, Nathanson, Katherine L., additional, Cortessis, Victoria K., additional, Hoadley, Katherine A., additional, Wheeler, David, additional, Hughes, Daniel, additional, Covington, Kyle, additional, Jayaseelan, Joy C., additional, Korchina, Viktoriya, additional, Lewis, Lora, additional, Hu, Jianhong, additional, Doddapaneni, HarshaVardhan, additional, Muzny, Donna, additional, Gibbs, Richard, additional, Hollern, Daniel, additional, Vincent, Benjamin G., additional, Chai, Shengjie, additional, Smith, Christof C., additional, Auman, J. Todd, additional, Shi, Yan, additional, Meng, Shaowu, additional, Skelly, Tara, additional, Tan, Donghui, additional, Veluvolu, Umadevi, additional, Mieczkowski, Piotr A., additional, Jones, Corbin D., additional, Wilkerson, Matthew D., additional, Balu, Saianand, additional, Bodenheimer, Tom, additional, Hoyle, Alan P., additional, Jefferys, Stuart R., additional, Mose, Lisle E., additional, Simons, Janae V., additional, Soloway, Matthew G., additional, Roach, Jeffrey, additional, Parker, Joel S., additional, Hayes, D. Neil, additional, Perou, Charles M., additional, Saksena, Gordon, additional, Cibulskis, Carrie, additional, Schumacher, Steven E., additional, Beroukhim, Rameen, additional, Gabriel, Stacey B., additional, Ally, Adrian, additional, Balasundaram, Miruna, additional, Carlsen, Rebecca, additional, Cheung, Dorothy, additional, Chuah, Eric, additional, Dhalla, Noreen, additional, Holt, Robert A., additional, Jones, Steven J.M., additional, Ma, Yussanne, additional, Mayo, Michael, additional, Moore, Richard A., additional, Robertson, A. Gordon, additional, Schein, Jacqueline E., additional, Sipahimalani, Payal, additional, Tam, Angela, additional, Thiessen, Nina, additional, Wong, Tina, additional, Marra, Marco A., additional, Shen, Hui, additional, Weisenberger, Daniel J., additional, Van Den Berg, David J., additional, Lai, Phillip H., additional, Berrios, Mario, additional, Holbrook, Andrea, additional, Bootwalla, Moiz S., additional, Maglinte, Dennis T., additional, Chakravarty, Debyani, additional, Gao, Jianjiong, additional, Heins, Zachary, additional, Kundra, Ritika, additional, Ochoa, Angelica, additional, Sander, Chris, additional, Ladanyi, Marc, additional, Thorsson, Vesteinn, additional, Radenbaugh, Amie J., additional, Gehlenborg, Nils, additional, Voet, Doug, additional, Lin, Pei, additional, Frazer, Scott, additional, Kim, Jaegil, additional, Lawrence, Michael S., additional, Meier, Sam, additional, Defreitas, Timothy, additional, Chin, Lynda, additional, Weinstein, John N., additional, Liu, Wenbin, additional, Mills, Gordon B., additional, Lu, Yiling, additional, Looijenga, Leendert, additional, Bryce, Alan H., additional, Carvalho, André L., additional, Feldman, Darren, additional, Ittmann, Michael, additional, Lerner, Seth, additional, Bowen, Jay, additional, Gastier-Foster, Julie M., additional, Gerken, Mark, additional, Helsel, Carmen, additional, Ramirez, Nilsa C., additional, Wise, Lisa, additional, Zmuda, Erik, additional, Cottingham, Sandra, additional, Chesla, David, additional, Saller, Charles, additional, Tarvin, Katherine, additional, Lopes, Luiz Fernando, additional, Scapulatempo-Neto, Cristovam, additional, Aredes, Natália D.A., additional, Oosterhuis, Wolter, additional, Gillis, Ad, additional, Stoop, Hans, additional, Eijkenboom, Wil, additional, Sandusky, George, additional, Martin, Sue Ellen, additional, Aron, Manju, additional, Daneshmand, Siamak, additional, Djaladat, Hooman, additional, Quinn, David, additional, Dorff, Tanya, additional, Lennerz, Jochen K., additional, Thorne, Leigh B., additional, Gamulin, Marija, additional, Kastelan, Zeljko, additional, Hudolin, Tvrtko, additional, Kubisch, Christian, additional, Boice, Lori, additional, Huang, Mei, additional, Perou, Amy H., additional, Rathmell, W. Kimryn, additional, Pihl, Todd, additional, Wan, Yunhu, additional, Sun, Qiang, additional, Naresh, Rashi, additional, Chudamani, Sudha, additional, Liu, Jia, additional, Lolla, Laxmi, additional, Wu, Ye, additional, Ferguson, Martin L., additional, Zenklusen, Jean C., additional, Zhang, Jiashan (Julia), additional, Sheth, Margi, additional, Demchok, John A., additional, Yang, Liming, additional, Wang, Zhining, additional, Tarnuzzer, Roy, additional, Sofia, Heidi J., additional, and Davidsen, Tanja M., additional

Published
2018
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8. Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Author

Abeshouse, Adam, primary, Adebamowo, Clement, additional, Adebamowo, Sally N., additional, Akbani, Rehan, additional, Akeredolu, Teniola, additional, Ally, Adrian, additional, Anderson, Matthew L., additional, Anur, Pavana, additional, Appelbaum, Elizabeth L., additional, Armenia, Joshua, additional, Auman, J. Todd, additional, Bailey, Matthew H., additional, Baker, Laurence, additional, Balasundaram, Miruna, additional, Balu, Saianand, additional, Barthel, Floris P., additional, Bartlett, John, additional, Baylin, Stephen B., additional, Behera, Madhusmita, additional, Belyaev, Dmitry, additional, Bennett, Joesph, additional, Benz, Christopher, additional, Beroukhim, Rameen, additional, Birrer, Michael, additional, Bocklage, Thèrése, additional, Bodenheimer, Tom, additional, Boice, Lori, additional, Bootwalla, Moiz S., additional, Bowen, Jay, additional, Bowlby, Reanne, additional, Boyd, Jeff, additional, Brohl, Andrew S., additional, Brooks, Denise, additional, Byers, Lauren, additional, Carlsen, Rebecca, additional, Castro, Patricia, additional, Chen, Hsiao-Wei, additional, Cherniack, Andrew D., additional, Chibon, Fréderic, additional, Chin, Lynda, additional, Cho, Juok, additional, Chuah, Eric, additional, Chudamani, Sudha, additional, Cibulskis, Carrie, additional, Cooper, Lee A.D., additional, Cope, Leslie, additional, Cordes, Matthew G., additional, Crain, Daniel, additional, Curley, Erin, additional, Danilova, Ludmila, additional, Dao, Fanny, additional, Davis, Ian J., additional, Davis, Lara E., additional, Defreitas, Timothy, additional, Delman, Keith, additional, Demchok, John A., additional, Demetri, George D., additional, Demicco, Elizabeth G., additional, Dhalla, Noreen, additional, Diao, Lixia, additional, Ding, Li, additional, DiSaia, Phil, additional, Dottino, Peter, additional, Doyle, Leona A., additional, Drill, Esther, additional, Dubina, Michael, additional, Eschbacher, Jennifer, additional, Fedosenko, Konstantin, additional, Felau, Ina, additional, Ferguson, Martin L., additional, Frazer, Scott, additional, Fronick, Catrina C., additional, Fulidou, Victoria, additional, Fulton, Lucinda A., additional, Fulton, Robert S., additional, Gabriel, Stacey B., additional, Gao, Jianjiong, additional, Gao, Qingsong, additional, Gardner, Johanna, additional, Gastier-Foster, Julie M., additional, Gay, Carl M., additional, Gehlenborg, Nils, additional, Gerken, Mark, additional, Getz, Gad, additional, Godwin, Andrew K., additional, Godwin, Eryn M., additional, Gordienko, Elena, additional, Grilley-Olson, Juneko E., additional, Gutman, David A., additional, Gutmann, David H., additional, Hayes, D. Neil, additional, Hegde, Apurva M., additional, Heiman, David I., additional, Heins, Zachary, additional, Helsel, Carmen, additional, Hepperla, Austin J., additional, Higgins, Kelly, additional, Hoadley, Katherine A., additional, Hobensack, Shital, additional, Holt, Robert A., additional, Hoon, Dave B., additional, Hornick, Jason L., additional, Hoyle, Alan P., additional, Hu, Xin, additional, Huang, Mei, additional, Hutter, Carolyn M., additional, Iacocca, Mary, additional, Ingram, Davis R., additional, Ittmann, Michael, additional, Iype, Lisa, additional, Jefferys, Stuart R., additional, Jones, Kevin B., additional, Jones, Corbin D., additional, Jones, Steven J.M., additional, Kalir, Tamara, additional, Karlan, Beth Y., additional, Karseladze, Apollon, additional, Kasaian, Katayoon, additional, Kim, Jaegil, additional, Kundra, Ritika, additional, Kuo, Hanluen, additional, Ladanyi, Marc, additional, Lai, Phillip H., additional, Laird, Peter W., additional, Larsson, Erik, additional, Lawrence, Michael S., additional, Lazar, Alexander J., additional, Lee, Sanghoon, additional, Lee, Darlene, additional, Lehmann, Kjong-Van, additional, Leraas, Kristen M., additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Irene, additional, Lichtenberg, Tara M., additional, Lin, Pei, additional, Liu, Jia, additional, Liu, Wenbin, additional, Liu, Eric Minwei, additional, Lolla, Laxmi, additional, Lu, Yiling, additional, Ma, Yussanne, additional, Madan, Rashna, additional, Maglinte, Dennis T., additional, Magliocco, Anthony, additional, Maki, Robert G., additional, Mallery, David, additional, Manikhas, Georgy, additional, Mardis, Elaine R., additional, Mariamidze, Armaz, additional, Marra, Marco A., additional, Martignetti, John A., additional, Martinez, Cathleen, additional, Mayo, Michael, additional, McLellan, Michael D., additional, Meier, Sam, additional, Meng, Shaowu, additional, Meyerson, Matthew, additional, Mieczkowski, Piotr A., additional, Miller, Christopher A., additional, Mills, Gordon B., additional, Moore, Richard A., additional, Morris, Scott, additional, Mose, Lisle E., additional, Mozgovoy, Evgeny, additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Nalisnik, Michael, additional, Naresh, Rashi, additional, Newton, Yulia, additional, Noble, Michael S., additional, Novak, Janet E., additional, Ochoa, Angelica, additional, Olvera, Narciso, additional, Owonikoko, Taofeek K., additional, Paklina, Oxana, additional, Parfitt, Jeremy, additional, Parker, Joel S., additional, Pastore, Alessandro, additional, Paulauskis, Joseph, additional, Penny, Robert, additional, Pereira, Elena, additional, Perou, Charles M., additional, Perou, Amy H., additional, Pihl, Todd, additional, Pollock, Raphael E., additional, Potapova, Olga, additional, Radenbaugh, Amie J., additional, Ramalingam, Suresh S., additional, Ramirez, Nilsa C., additional, Rathmell, W. Kimryn, additional, Raut, Chandrajit P., additional, Riedel, Richard F., additional, Reilly, Colleen, additional, Reynolds, Sheila M., additional, Roach, Jeffrey, additional, Robertson, A. Gordon, additional, Roszik, Jason, additional, Rubin, Brian P., additional, Sadeghi, Sara, additional, Saksena, Gordon, additional, Salner, Andrew, additional, Sanchez-Vega, Francisco, additional, Sander, Chris, additional, Schein, Jacqueline E., additional, Schmidt, Heather K., additional, Schultz, Nikolaus, additional, Schumacher, Steven E., additional, Sekhon, Harman, additional, Senbabaoglu, Yasin, additional, Setdikova, Galiya, additional, Shelton, Candace, additional, Shelton, Troy, additional, Shen, Ronglai, additional, Shi, Yan, additional, Shih, Juliann, additional, Shmulevich, Ilya, additional, Sica, Gabriel L., additional, Simons, Janae V., additional, Singer, Samuel, additional, Sipahimalani, Payal, additional, Skelly, Tara, additional, Socci, Nicholas, additional, Sofia, Heidi J., additional, Soloway, Matthew G., additional, Spellman, Paul, additional, Sun, Qiang, additional, Swanson, Patricia, additional, Tam, Angela, additional, Tan, Donghui, additional, Tarnuzzer, Roy, additional, Thiessen, Nina, additional, Thompson, Eric, additional, Thorne, Leigh B., additional, Tong, Pan, additional, Torres, Keila E., additional, van de Rijn, Matt, additional, Van Den Berg, David J., additional, Van Tine, Brian A., additional, Veluvolu, Umadevi, additional, Verhaak, Roel, additional, Voet, Doug, additional, Voronina, Olga, additional, Wan, Yunhu, additional, Wang, Zhining, additional, Wang, Jing, additional, Weinstein, John N., additional, Weisenberger, Daniel J., additional, Wilkerson, Matthew D., additional, Wilson, Richard K., additional, Wise, Lisa, additional, Wong, Tina, additional, Wong, Winghing, additional, Wrangle, John, additional, Wu, Ye, additional, Wyczalkowski, Matthew, additional, Yang, Liming, additional, Yau, Christina, additional, Yellapantula, Venkata, additional, Zenklusen, Jean C., additional, Zhang, Jiashan (Julia), additional, Zhang, Hailei, additional, Zhang, Hongxin, additional, and Zmuda, Erik, additional

Published
2017
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9. Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

Author

Zheng, Siyuan, primary, Cherniack, Andrew D., additional, Dewal, Ninad, additional, Moffitt, Richard A., additional, Danilova, Ludmila, additional, Murray, Bradley A., additional, Lerario, Antonio M., additional, Else, Tobias, additional, Knijnenburg, Theo A., additional, Ciriello, Giovanni, additional, Kim, Seungchan, additional, Assie, Guillaume, additional, Morozova, Olena, additional, Akbani, Rehan, additional, Shih, Juliann, additional, Hoadley, Katherine A., additional, Choueiri, Toni K., additional, Waldmann, Jens, additional, Mete, Ozgur, additional, Robertson, A. Gordon, additional, Wu, Hsin-Ta, additional, Raphael, Benjamin J., additional, Shao, Lina, additional, Meyerson, Matthew, additional, Demeure, Michael J., additional, Beuschlein, Felix, additional, Gill, Anthony J., additional, Sidhu, Stan B., additional, Almeida, Madson Q., additional, Fragoso, Maria C.B.V., additional, Cope, Leslie M., additional, Kebebew, Electron, additional, Habra, Mouhammed A., additional, Whitsett, Timothy G., additional, Bussey, Kimberly J., additional, Rainey, William E., additional, Asa, Sylvia L., additional, Bertherat, Jérôme, additional, Fassnacht, Martin, additional, Wheeler, David A., additional, Hammer, Gary D., additional, Giordano, Thomas J., additional, Verhaak, Roel G.W., additional, Zheng, Siyuan, additional, Assié, Guillaume, additional, Wu, Hsin-Tu, additional, Almeida, Madson, additional, Barisson Fragoso, Maria Candida, additional, Habra, Mouhammed Amir, additional, Benz, Christopher, additional, Ally, Adrian, additional, Balasundaram, Miruna, additional, Bowlby, Reanne, additional, Brooks, Denise, additional, Butterfield, Yaron S.N., additional, Carlsen, Rebecca, additional, Dhalla, Noreen, additional, Guin, Ranabir, additional, Holt, Robert A., additional, Jones, Steven J.M., additional, Kasaian, Katayoon, additional, Lee, Darlene, additional, Li, Haiyan I., additional, Lim, Lynette, additional, Ma, Yussanne, additional, Marra, Marco A., additional, Mayo, Michael, additional, Moore, Richard A., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Sadeghi, Sara, additional, Schein, Jacqueline E., additional, Sipahimalani, Payal, additional, Tam, Angela, additional, Thiessen, Nina, additional, Park, Peter J., additional, Kroiss, Matthias, additional, Gao, Jianjiong, additional, Sander, Chris, additional, Schultz, Nikolaus, additional, Jones, Corbin D., additional, Kucherlapati, Raju, additional, Mieczkowski, Piotr A., additional, Parker, Joel S., additional, Perou, Charles M., additional, Tan, Donghui, additional, Veluvolu, Umadevi, additional, Wilkerson, Matthew D., additional, Hayes, D. Neil, additional, Ladanyi, Marc, additional, Quinkler, Marcus, additional, Auman, J. Todd, additional, Latronico, Ana Claudia, additional, Mendonca, Berenice B., additional, Sibony, Mathilde, additional, Sanborn, Zack, additional, Bellair, Michelle, additional, Buhay, Christian, additional, Covington, Kyle, additional, Dahdouli, Mahmoud, additional, Dinh, Huyen, additional, Doddapaneni, Harsha, additional, Downs, Brittany, additional, Drummond, Jennifer, additional, Gibbs, Richard, additional, Hale, Walker, additional, Han, Yi, additional, Hawes, Alicia, additional, Hu, Jianhong, additional, Kakkar, Nipun, additional, Kalra, Divya, additional, Khan, Ziad, additional, Kovar, Christine, additional, Lee, Sandy, additional, Lewis, Lora, additional, Morgan, Margaret, additional, Morton, Donna, additional, Muzny, Donna, additional, Santibanez, Jireh, additional, Xi, Liu, additional, Dousset, Bertrand, additional, Groussin, Lionel, additional, Libé, Rossella, additional, Chin, Lynda, additional, Reynolds, Sheila, additional, Shmulevich, Ilya, additional, Chudamani, Sudha, additional, Liu, Jia, additional, Lolla, Laxmi, additional, Wu, Ye, additional, Yeh, Jen Jen, additional, Balu, Saianand, additional, Bodenheimer, Tom, additional, Hoyle, Alan P., additional, Jefferys, Stuart R., additional, Meng, Shaowu, additional, Mose, Lisle E., additional, Shi, Yan, additional, Simons, Janae V., additional, Soloway, Matthew G., additional, Wu, Junyuan, additional, Zhang, Wei, additional, Mills Shaw, Kenna R., additional, Demchok, John A., additional, Felau, Ina, additional, Sheth, Margi, additional, Tarnuzzer, Roy, additional, Wang, Zhining, additional, Yang, Liming, additional, Zenklusen, Jean C., additional, Zhang, Jiashan (Julia), additional, Davidsen, Tanja, additional, Crawford, Catherine, additional, Hutter, Carolyn M., additional, Sofia, Heidi J., additional, Roach, Jeffrey, additional, Bshara, Wiam, additional, Gaudioso, Carmelo, additional, Morrison, Carl, additional, Soon, Patsy, additional, Alonso, Shelley, additional, Baboud, Julien, additional, Pihl, Todd, additional, Raman, Rohini, additional, Sun, Qiang, additional, Wan, Yunhu, additional, Naresh, Rashi, additional, Arachchi, Harindra, additional, Beroukhim, Rameen, additional, Carter, Scott L., additional, Cho, Juok, additional, Frazer, Scott, additional, Gabriel, Stacey B., additional, Getz, Gad, additional, Heiman, David I., additional, Kim, Jaegil, additional, Lawrence, Michael S., additional, Lin, Pei, additional, Noble, Michael S., additional, Saksena, Gordon, additional, Schumacher, Steven E., additional, Sougnez, Carrie, additional, Voet, Doug, additional, Zhang, Hailei, additional, Bowen, Jay, additional, Coppens, Sara, additional, Gastier-Foster, Julie M., additional, Gerken, Mark, additional, Helsel, Carmen, additional, Leraas, Kristen M., additional, Lichtenberg, Tara M., additional, Ramirez, Nilsa C., additional, Wise, Lisa, additional, Zmuda, Erik, additional, Baylin, Stephen, additional, Herman, James G., additional, LoBello, Janine, additional, Watanabe, Aprill, additional, Haussler, David, additional, Radenbaugh, Amie, additional, Rao, Arjun, additional, Zhu, Jingchun, additional, Bartsch, Detlef K., additional, Sbiera, Silviu, additional, Allolio, Bruno, additional, Deutschbein, Timo, additional, Ronchi, Cristina, additional, Raymond, Victoria M., additional, Vinco, Michelle, additional, Amble, Linda, additional, Bootwalla, Moiz S., additional, Lai, Phillip H., additional, Van Den Berg, David J., additional, Weisenberger, Daniel J., additional, Robinson, Bruce, additional, Ju, Zhenlin, additional, Kim, Hoon, additional, Ling, Shiyun, additional, Liu, Wenbin, additional, Lu, Yiling, additional, Mills, Gordon B., additional, Sircar, Kanishka, additional, Wang, Qianghu, additional, Yoshihara, Kosuke, additional, Laird, Peter W., additional, Fan, Yu, additional, Wang, Wenyi, additional, Shinbrot, Eve, additional, Reincke, Martin, additional, Weinstein, John N., additional, Meier, Sam, additional, and Defreitas, Timothy, additional

Published
2016
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10. Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

Author

Santibanez, Jireh, Robertson, A. Gordon, Meng, Shaowu, Pihl, Todd, Auman, J. Todd, Wilkerson, Matthew D., Hoadley, Katherine A., Bussey, Kimberly J., Wu, Hsin-Ta, Crawford, Catherine, Sibony, Mathilde, Cope, Leslie M., Arachchi, Harindra, Sander, Chris, Wang, Zhining, Gill, Anthony J., Bodenheimer, Tom, Shinbrot, Eve, Mayo, Michael, Hu, Jianhong, Liu, Jia, Choueiri, Toni K., Mills, Gordon B., Davidsen, Tanja, Raphael, Benjamin J., Balu, Saianand, Ciriello, Giovanni, Jones, Corbin D., Guin, Ranabir, Hammer, Gary D., Lerario, Antonio M., Hoyle, Alan P., Weisenberger, Daniel J., Giordano, Thomas J., Radenbaugh, Amie, Cho, Juok, Ling, Shiyun, Sofia, Heidi J., Zhu, Jingchun, Wu, Junyuan, Khan, Ziad, Amble, Linda, Naresh, Rashi, Dousset, Bertrand, Shao, Lina, Shih, Juliann, Waldmann, Jens, Coppens, Sara, Lee, Darlene, Demchok, John A., Doddapaneni, Harsha, Danilova, Ludmila, Wang, Wenyi, Mose, Lisle E., Kim, Hoon, Beroukhim, Rameen, Morgan, Margaret, Wan, Yunhu, Hutter, Carolyn M., Kovar, Christine, Latronico, Ana Claudia, Rao, Arjun, Marra, Marco A., Knijnenburg, Theo A., Almeida, Madson Q., Ju, Zhenlin, Sougnez, Carrie, Kroiss, Matthias, Shi, Yan, Wu, Ye, Shmulevich, Ilya, Gaudioso, Carmelo, Akbani, Rehan, Mungall, Karen, Felau, Ina, Schein, Jacqueline E., Gibbs, Richard, Morozova, Olena, Moffitt, Richard A., Weinstein, John N., Fragoso, Maria C.B.V., Verhaak, Roel G.W., Dewal, Ninad, Soloway, Matthew G., Kalra, Divya, Lawrence, Michael S., Defreitas, Timothy, Ronchi, Cristina, Kasaian, Katayoon, Park, Peter J., Demeure, Michael J., Hayes, D. Neil, Herman, James G., Parker, Joel S., Morton, Donna, Reincke, Martin, Han, Yi, Lee, Sandy, Sanborn, Zack, Wheeler, David A., Xi, Liu, Lim, Lynette, Soon, Patsy, Leraas, Kristen M., Zmuda, Erik, Buhay, Christian, Benz, Christopher, Bowlby, Reanne, Liu, Wenbin, Fan, Yu, Cherniack, Andrew D., Bootwalla, Moiz S., Hawes, Alicia, Mendonca, Berenice B., Sidhu, Stan B., Noble, Michael S., Alonso, Shelley, Van Den Berg, David J., Raman, Rohini, Bshara, Wiam, Murray, Bradley A., Zenklusen, Jean C., Laird, Peter W., Beuschlein, Felix, Carter, Scott L., Tarnuzzer, Roy, Schumacher, Steven E., Gerken, Mark, Saksena, Gordon, Kim, Seungchan, Else, Tobias, Allolio, Bruno, Sun, Qiang, Mungall, Andrew J., Jefferys, Stuart R., Zheng, Siyuan, Frazer, Scott, Gao, Jianjiong, Morrison, Carl, Lin, Pei, Butterfield, Yaron S.N., Lai, Phillip H., Groussin, Lionel, Raymond, Victoria M., Ma, Yussanne, Bertherat, Jérôme, Meier, Sam, Gabriel, Stacey B., Mieczkowski, Piotr A., Meyerson, Matthew, Lu, Yiling, Zhang, Jiashan, Whitsett, Timothy G., Yeh, Jen Jen, Brooks, Denise, Dhalla, Noreen, Perou, Charles M., Roach, Jeffrey, Libé, Rossella, Rainey, William E., Ladanyi, Marc, Thiessen, Nina, Lolla, Laxmi, Wang, Qianghu, Holt, Robert A., Tam, Angela, Zhang, Wei, Watanabe, Aprill, Moore, Richard A., Reynolds, Sheila, Baylin, Stephen, Chudamani, Sudha, Simons, Janae V., Zhang, Hailei, Asa, Sylvia L., Lichtenberg, Tara M., Quinkler, Marcus, Ramirez, Nilsa C., Hale, Walker, Voet, Doug, Bowen, Jay, Chin, Lynda, Bartsch, Detlef K., Sadeghi, Sara, Getz, Gad, Covington, Kyle, Wise, Lisa, Veluvolu, Umadevi, Li, Haiyan I., Sipahimalani, Payal, Sheth, Margi, Fassnacht, Martin, Carlsen, Rebecca, Gastier-Foster, Julie M., Haussler, David, Baboud, Julien, Tan, Donghui, Yoshihara, Kosuke, Habra, Mouhammed A., Kucherlapati, Raju, Muzny, Donna, Kim, Jaegil, Sbiera, Silviu, Downs, Brittany, Drummond, Jennifer, Yang, Liming, Schultz, Nikolaus, Deutschbein, Timo, Ally, Adrian, Dinh, Huyen, Balasundaram, Miruna, Sircar, Kanishka, Kakkar, Nipun, Helsel, Carmen, Lewis, Lora, Kebebew, Electron, Jones, Steven J.M., Dahdouli, Mahmoud, Heiman, David I., Robinson, Bruce, LoBello, Janine, Shaw, Kenna R. Mills, Mete, Ozgur, Vinco, Michelle, Assie, Guillaume, and Bellair, Michelle

Subjects
3. Good health
Abstract

SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.

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