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1. Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

Author

Kümpfel, Tania, Giglhuber, Katrin, Aktas, Orhan, Ayzenberg, Ilya, Bellmann-Strobl, Judith, Häußler, Vivien, Havla, Joachim, Hellwig, Kerstin, Hümmert, Martin W., Jarius, Sven, Kleiter, Ingo, Klotz, Luisa, Krumbholz, Markus, Paul, Friedemann, Ringelstein, Marius, Ruprecht, Klemens, Senel, Makbule, Stellmann, Jan-Patrick, Bergh, Florian Then, Trebst, Corinna, Tumani, Hayrettin, Warnke, Clemens, Wildemann, Brigitte, and Berthele, Achim

Published
2024
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4. Anti-CD20 monoclonal antibody therapy in postpartum women with neurological conditions.

Author

Anderson, Annika, Rowles, William, Poole, Shane, Balan, Ayushi, Bevan, Carolyn, Brandstadter, Rachel, Ciplea, Andrea, Cooper, Joanna, Fabian, Michelle, Hale, Thomas, Jacobs, Dina, Kakara, Mihir, Krysko, Kristen, Longbrake, Erin, Marcus, Jacqueline, Repovic, Pavle, Riley, Claire, Romeo, Andrew, West, Timothy, Hellwig, Kerstin, LaHue, Sara, Bove, Riley, and Edwards, Alice

Subjects
Pregnancy, Infant, Child, Humans, Female, Antibodies, Monoclonal, Rituximab, Postpartum Period, Antineoplastic Agents, Multiple Sclerosis, Immunoglobulin G
Abstract

OBJECTIVE: Postpartum, patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have increased risk for disease activity. Anti-CD20 IgG1 monoclonal antibodies (mAb) are increasingly used as disease-modifying therapies (DMTs). Patients may wish to both breastfeed and resume DMT postpartum. This study aimed to determine the transfer of anti-CD20 IgG1 mAbs, ocrelizumab, and rituximab (OCR/RTX), into mature breastmilk and describe maternal and infant outcomes. METHODS: Fifty-seven cis-women receiving OCR/RTX after 59 pregnancies and their infants were enrolled and followed up to 12M postpartum or 90 days post-infusion. Breastmilk was collected pre-infusion and serially up to 90 days and assayed for mAb concentration. Medical records and patients questionnaire responses were obtained to assess neurologic, breastfeeding, and infant development outcomes. RESULTS: The median average concentration of mAb in breastmilk was low (OCR: 0.08 μg/mL, range 0.05-0.4; RTX: 0.03 μg/mL, range 0.005-0.3). Concentration peaked 1-7 days post-infusion in most (77%) and was nearly undetectable after 90 days. Median average relative infant dose was  0.05) infants; neither did the proportion with normal development (breastfed: 37/41, non-breastfed: 11/13; p > 0.05). After postpartum infusion, two mothers experienced a clinical relapse. INTERPRETATION: These confirm minimal transfer of mAb into breastmilk. Anti-CD20 mAb therapy stabilizes MS activity before conception to the postpartum period, and postpartum treatments appears to be safe and well-tolerated for both mother and infant.

Published
2023

5. Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)

Author

Holz, Anja, Obi, Nadia, Ahrens, Wolfgang, Berger, Klaus, Bohn, Barbara, Brenner, Hermann, Fischer, Beate, Fricke, Julia, Führer, Amand, Gastell, Sylvia, Greiser, Karin Halina, Harth, Volker, Heise, Jana-Kristin, Holleczek, Bernd, Keil, Thomas, Klett-Tammen, Carolina J., Leitzmann, Michael, Lieb, Wolfgang, Meinke-Franze, Claudia, Michels, Karin B., Mikolajczyk, Rafael, Nimptsch, Katharina, Peters, Annette, Pischon, Tobias, Riedel, Oliver, Schikowski, Tamara, Schipf, Sabine, Schmidt, Börge, Schulze, Matthias B., Stang, Andreas, Hellwig, Kerstin, Riemann-Lorenz, Karin, Heesen, Christoph, and Becher, Heiko

Published
2024
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6. Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

Author

Kümpfel, Tania, Giglhuber, Katrin, Aktas, Orhan, Ayzenberg, Ilya, Bellmann-Strobl, Judith, Häußler, Vivien, Havla, Joachim, Hellwig, Kerstin, Hümmert, Martin W., Jarius, Sven, Kleiter, Ingo, Klotz, Luisa, Krumbholz, Markus, Paul, Friedemann, Ringelstein, Marius, Ruprecht, Klemens, Senel, Makbule, Stellmann, Jan-Patrick, Bergh, Florian Then, Trebst, Corinna, Tumani, Hayrettin, Warnke, Clemens, Wildemann, Brigitte, and Berthele, Achim

Published
2024
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8. Use and effectiveness of remdesivir for the treatment of patients with covid-19 using data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS): a multicentre cohort study

Author

Pilgram, Lisa, Appel, Katharina S., Ruethrich, Maria M., Koll, Carolin E. M., Vehreschild, Maria J. G. T., de Miranda, Susana M. Nunes, Hower, Martin, Hellwig, Kerstin, Hanses, Frank, Wille, Kai, Haselberger, Martina, Spinner, Christoph D., Vom Dahl, Juergen, Hertenstein, Bernd, Westhoff, Timm, Vehreschild, J. Janne, Jensen, Björn-Erik Ole, and Stecher, Melanie

Published
2023
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10. Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis

Author

Jarius, Sven, Aktas, Orhan, Ayzenberg, Ilya, Bellmann-Strobl, Judith, Berthele, Achim, Giglhuber, Katrin, Häußler, Vivien, Havla, Joachim, Hellwig, Kerstin, Hümmert, Martin W., Kleiter, Ingo, Klotz, Luisa, Krumbholz, Markus, Kümpfel, Tania, Paul, Friedemann, Ringelstein, Marius, Ruprecht, Klemens, Senel, Makbule, Stellmann, Jan-Patrick, Bergh, Florian Then, Tumani, Hayrettin, Wildemann, Brigitte, and Trebst, Corinna

Published
2023
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11. Association of health behaviour and clinical manifestation in early multiple sclerosis in Germany – Baseline characteristics of the POWER@MS1 randomised controlled trial

Author

Bähr, Dieter, Berthele, Achim, Blersch, Wendelin, Gass, Achim, Gehring, Klaus, Grothe, Matthias, Hellwig, Kerstin, Kallmann, Boris-Alexander, Klehmet, Juliane, Krüger, Schulamith, Mäurer, Mathias, Meya, Stefan, Oschmann, Patrick, Pul, Refik, Roick, Holger, Schmidt, Stephan, Steinbrecher, Andreas, Stürner, Klarissa H., Warnke, Clemens, Göreci, Yasemin, Krause, Nicole, Derad, Carlotta, von Glasenapp, Barbara, Riemann-Lorenz, Karin, Temmes, Herbert, van de Loo, Markus, Friede, Tim, Asendorf, Thomas, and Heesen, Christoph

Published
2023
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15. Sex effects across the lifespan in women with multiple sclerosis

Author

Krysko, Kristen M, Graves, Jennifer S, Dobson, Ruth, Altintas, Ayse, Amato, Maria Pia, Bernard, Jacqueline, Bonavita, Simona, Bove, Riley, Cavalla, Paola, Clerico, Marinella, Corona, Teresa, Doshi, Anisha, Fragoso, Yara, Jacobs, Dina, Jokubaitis, Vilija, Landi, Doriana, Llamosa, Gloria, Longbrake, Erin E, Maillart, Elisabeth, Marta, Monica, Midaglia, Luciana, Shah, Suma, Tintore, Mar, van der Walt, Anneke, Voskuhl, Rhonda, Wang, Yujie, Zabad, Rana K, Zeydan, Burcu, Houtchens, Maria, and Hellwig, Kerstin

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Neurosciences, Contraception/Reproduction, Aging, Neurodegenerative, Multiple Sclerosis, Prevention, Autoimmune Disease, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Reproductive health and childbirth, Good Health and Well Being, breastfeeding, multiple sclerosis, pregnancy, sex differences, sex hormones, women
Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating central nervous system disorder that is more common in women, with onset often during reproductive years. The female:male sex ratio of MS rose in several regions over the last century, suggesting a possible sex by environmental interaction increasing MS risk in women. Since many with MS are in their childbearing years, family planning, including contraceptive and disease-modifying therapy (DMT) counselling, are important aspects of MS care in women. While some DMTs are likely harmful to the developing fetus, others can be used shortly before or until pregnancy is confirmed. Overall, pregnancy decreases risk of MS relapses, whereas relapse risk may increase postpartum, although pregnancy does not appear to be harmful for long-term prognosis of MS. However, ovarian aging may contribute to disability progression in women with MS. Here, we review sex effects across the lifespan in women with MS, including the effect of sex on MS susceptibility, effects of pregnancy on MS disease activity, and management strategies around pregnancy, including risks associated with DMT use before and during pregnancy, and while breastfeeding. We also review reproductive aging and sexual dysfunction in women with MS.

Published
2020

16. Multiple sclerosis progression: time for a new mechanism-driven framework

Author

Amato, Maria Pia, Banwell, Brenda, Barkhof, Frederik, Chataway, Jeremy, Chitnis, Tanuja, Comi, Giancarlo, Derfuss, Tobias, Finlayson, Marcia, Goldman, Myla, Green, Ari, Hellwig, Kerstin, Kos, Daphne, Miller, Aaron, Mowry, Ellen, Oh, Jiwon, Salter, Amber, Sormani, Maria Pia, Tintore, Mar, Tremlett, Helen, Trojano, Maria, van der Walt, Anneke, Vukusic, Sandra, Waubant, Emmaunelle, Kuhlmann, Tanja, Moccia, Marcello, Coetzee, Timothy, Cohen, Jeffrey A, Correale, Jorge, Graves, Jennifer, Marrie, Ruth Ann, Montalban, Xavier, Yong, V Wee, Thompson, Alan J, and Reich, Daniel S

Published
2023
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18. Pregnancy and Infant Outcomes in Females Receiving Ocrelizumab for the Treatment of Multiple Sclerosis: Analysis of over 3,000 Pregnancies to Date (S7.004)

Author

Bove, Riley, primary, Pietrasanta, Carlo, additional, Oreja-Guevara, Celia, additional, Hellwig, Kerstin, additional, Dobson, Ruth, additional, Vukusic, Sandra, additional, Lin, Chien-Ju, additional, Alvarez, Daniela Goncalves Pereira, additional, Zecevic, Dusanka, additional, Ferreira, Germano, additional, Craveiro, Licinio, additional, Pasquarelli, Noemi, additional, and McElrath, Thomas, additional

Published
2024
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27. Seizure Semiology in Antibody-Associated Autoimmune Encephalitis

Author

Kaaden, Tillman, Madlener, Marie, Angstwurm, Klemens, Bien, Christian G., Bogarin, Yuri, Doppler, Kathrin, Finke, Alexander, Gerner, Stefan T., Reimann, Gernot, Häusler, Martin, Handreka, Robert, Hellwig, Kerstin, Kaufmann, Max, Kellinghaus, Christoph, Koertvelyessy, Peter, Kraft, Andrea, Lewerenz, Jan, Menge, Til, Paliantonis, Asterios, von Podewils, Felix, Prüss, Harald, Rauer, Sebastian, Ringelstein, Marius, Rostásy, Kevin, Schirotzek, Ingo, Schwabe, Julia, Sokolowski, Piotr, Suesse, Marie, Sühs, Kurt-Wolfram, Surges, Rainer, Tauber, Simone C., Thaler, Franziska, Bergh, Florian Then, Urbanek, Christian, Wandinger, Klaus-P., Wildemann, Brigitte, Mues, Sigrid, Zettl, Uwe, Leypoldt, Frank, Melzer, Nico, Geis, Christian, Malter, Michael, and Kunze, Albrecht

Published
2022
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28. Restoring immune tolerance in neuromyelitis optica

Author

Steinman, Larry, Bar-Or, Amit, Behne, Jacinta M, Benitez-Ribas, Daniel, Chin, Peter S, Clare-Salzler, Michael, Healey, Donald, Kim, James I, Kranz, David M, Lutterotti, Andreas, Martin, Roland, Schippling, Sven, Villoslada, Pablo, Wei, Cheng-Hong, Weiner, Howard L, Zamvil, Scott S, Yeaman, Michael R, Smith, Terry J, Aktas, Orhan, Amezcua, Lilyana, Appiwatanakul, Metha, Asgari, Nasrin, Banwell, Brenda, Bennett, Jeffrey, Bowen, James, Cabre, Philippe, Chitnis, Tanuja, Cohen, Jeffrey, De Seze, Jerome, Fujihara, Kazuo, Han, May, Hellwig, Kerstin, Hintzen, Rogier, Hooper, D Craig, Iorio, Raffaele, Jacob, Anu, Jarius, Sven, Kim, Ho Jin, Kissani, Najib, Klawiter, Eric C, Kleiter, Ingo, Lana-Peixoto, Marco, Leite, Maria Isabel, Levy, Michael, Lublin, Fred, Draayer, Yang Mao, Marignier, Romain, Matiello, Marcelo, Nakashima, Ichiro, O’Connor, Kevin C, Palace, Jacqueline, Pandit, Lekha, Paul, Friedemann, Prayoonwiwat, Naraporn, Riley, Claire, Ruprecht, Klemens, Saiz, Albert, Siritho, Sasitorn, Tenembaum, Silvia, Weinshenker, Brian, Wingerchuk, Dean, and Würfel, Jens

Subjects
Biomedical and Clinical Sciences, Immunology, Neurosciences, Neurodegenerative, Eye Disease and Disorders of Vision, Multiple Sclerosis, Clinical Research, Brain Disorders, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors
Abstract

Neuromyelitis optica (NMO) and spectrum disorder (NMO/SD) represent a vexing process and its clinical variants appear to have at their pathogenic core the loss of immune tolerance to the aquaporin-4 water channel protein. This process results in a characteristic pattern of astrocyte dysfunction, loss, and demyelination that predominantly affects the spinal cord and optic nerves. Although several empirical therapies are currently used in the treatment of NMO/SD, none has been proven effective in prospective, adequately powered, randomized trials. Furthermore, most of the current therapies subject patients to long-term immunologic suppression that can cause serious infections and development of cancers. The following is the first of a 2-part description of several key immune mechanisms in NMO/SD that might be amenable to therapeutic restoration of immune tolerance. It is intended to provide a roadmap for how potential immune tolerance restorative techniques might be applied to patients with NMO/SD. This initial installment provides a background rationale underlying attempts at immune tolerization. It provides specific examples of innovative approaches that have emerged recently as a consequence of technical advances. In several autoimmune diseases, these strategies have been reduced to practice. Therefore, in theory, the identification of aquaporin-4 as the dominant autoantigen makes NMO/SD an ideal candidate for the development of tolerizing therapies or cures for this increasingly recognized disease.

Published
2016

29. Restoring immune tolerance in neuromyelitis optica

Author

Bar-Or, Amit, Steinman, Larry, Behne, Jacinta M, Benitez-Ribas, Daniel, Chin, Peter S, Clare-Salzler, Michael, Healey, Donald, Kim, James I, Kranz, David M, Lutterotti, Andreas, Martin, Roland, Schippling, Sven, Villoslada, Pablo, Wei, Cheng-Hong, Weiner, Howard L, Zamvil, Scott S, Smith, Terry J, Yeaman, Michael R, Aktas, Orhan, Amezcua, Lilyana, Appiwatanakul, Metha, Asgari, Nasrin, Banwell, Brenda, Bennett, Jeffrey, Bowen, James, Cabre, Philippe, Chitnis, Tanuja, Cohen, Jeffrey, De Seze, Jerome, Fujihara, Kazuo, Han, May, Hellwig, Kerstin, Hintzen, Rogier, Hooper, D Craig, Iorio, Raffaele, Jacob, Anu, Jarius, Sven, Kim, Ho Jin, Kissani, Najib, Klawiter, Eric C, Kleiter, Ingo, Lana-Peixoto, Marco, Leite, Maria Isabel, Levy, Michael, Lublin, Fred, Draayer, Yang Mao, Marignier, Romain, Matiello, Marcelo, Nakashima, Ichiro, O’Connor, Kevin C, Palace, Jacqueline, Pandit, Lekha, Paul, Friedemann, Prayoonwiwat, Naraporn, Riley, Claire, Ruprecht, Klemens, Saiz, Albert, Siritho, Sasitorn, Tenembaum, Silvia, Weinshenker, Brian, Wingerchuk, Dean, and Würfel, Jens

Subjects
Biomedical and Clinical Sciences, Immunology, Multiple Sclerosis, Autoimmune Disease, Neurosciences, Brain Disorders, Neurodegenerative, Eye Disease and Disorders of Vision, Aetiology, 2.1 Biological and endogenous factors
Abstract

Neuromyelitis optica spectrum disorder (NMO/SD) and its clinical variants have at their core the loss of immune tolerance to aquaporin-4 and perhaps other autoantigens. The characteristic phenotype is disruption of astrocyte function and demyelination of spinal cord, optic nerves, and particular brain regions. In this second of a 2-part article, we present further perspectives regarding the pathogenesis of NMO/SD and how this disease might be amenable to emerging technologies aimed at restoring immune tolerance to disease-implicated self-antigens. NMO/SD appears to be particularly well-suited for these strategies since aquaporin-4 has already been identified as the dominant autoantigen. The recent technical advances in reintroducing immune tolerance in experimental models of disease as well as in humans should encourage quantum leaps in this area that may prove productive for novel therapy. In this part of the article series, the potential for regulatory T and B cells is brought into focus, as are new approaches to oral tolerization. Finally, a roadmap is provided to help identify potential issues in clinical development and guide applications in tolerization therapy to solving NMO/SD through the use of emerging technologies. Each of these perspectives is intended to shine new light on potential cures for NMO/SD and other autoimmune diseases, while sparing normal host defense mechanisms.

Published
2016

30. First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”

Author

Jakob, Carolin E. M., Borgmann, Stefan, Duygu, Fazilet, Behrends, Uta, Hower, Martin, Merle, Uta, Friedrichs, Anette, Tometten, Lukas, Hanses, Frank, Jung, Norma, Rieg, Siegbert, Wille, Kai, Grüner, Beate, Klinker, Hartwig, Gersbacher-Runge, Nicole, Hellwig, Kerstin, Eberwein, Lukas, Dolff, Sebastian, Rauschning, Dominic, von Bergwelt-Baildon, Michael, Lanznaster, Julia, Strauß, Richard, Trauth, Janina, de With, Katja, Ruethrich, Maria, Lueck, Catherina, Nattermann, Jacob, Tscharntke, Lene, Pilgram, Lisa, Fuhrmann, Sandra, Classen, Annika, Stecher, Melanie, Schons, Maximilian, Spinner, Christoph, and Vehreschild, Jörg Janne

Published
2021
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33. Association of health behaviour and clinical manifestation in early multiple sclerosis in Germany – Baseline characteristics of the POWER@MS1 randomised controlled trial

Author

Krause, Nicole, primary, Derad, Carlotta, additional, von Glasenapp, Barbara, additional, Riemann-Lorenz, Karin, additional, Temmes, Herbert, additional, van de Loo, Markus, additional, Friede, Tim, additional, Asendorf, Thomas, additional, Heesen, Christoph, additional, Bähr, Dieter, additional, Berthele, Achim, additional, Blersch, Wendelin, additional, Gass, Achim, additional, Gehring, Klaus, additional, Grothe, Matthias, additional, Hellwig, Kerstin, additional, Kallmann, Boris-Alexander, additional, Klehmet, Juliane, additional, Krüger, Schulamith, additional, Mäurer, Mathias, additional, Meya, Stefan, additional, Oschmann, Patrick, additional, Pul, Refik, additional, Roick, Holger, additional, Schmidt, Stephan, additional, Steinbrecher, Andreas, additional, Stürner, Klarissa H., additional, Warnke, Clemens, additional, and Göreci, Yasemin, additional

Published
2023
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35. Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well?

Author

Havla, Joachim, Pakeerathan, Thivya, Schwake, Carolin, Bennett, Jeffrey L., Kleiter, Ingo, Felipe-Rucián, Ana, Joachim, Stephanie C., Lotz-Havla, Amelie S., Kümpfel, Tania, Krumbholz, Markus, Wendel, Eva M., Reindl, Markus, Thiels, Charlotte, Lücke, Thomas, Hellwig, Kerstin, Gold, Ralf, Rostasy, Kevin, and Ayzenberg, Ilya

Published
2021
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39. Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG–Associated Disease and Neuromyelitis Optica Spectrum Disorders

Author

Ringelstein, Marius, Ayzenberg, Ilya, Lindenblatt, Gero, Fischer, Katinka, Gahlen, Anna, Novi, Giovanni, Hayward-Könnecke, Helen, Schippling, Sven, Rommer, Paulus S., Kornek, Barbara, Zrzavy, Tobias, Biotti, Damien, Ciron, Jonathan, Audoin, Bertrand, Berthele, Achim, Giglhuber, Katrin, Zephir, Helene, Kümpfel, Tania, Berger, Robert, Röther, Joachim, Häußler, Vivien, Stellmann, Jan-Patrick, Whittam, Daniel, Jacob, Anu, Kraemer, Markus, Gueguen, Antoine, Deschamps, Romain, Bayas, Antonios, Hümmert, Martin W., Trebst, Corinna, Haarmann, Axel, Jarius, Sven, Wildemann, Brigitte, Grothe, Matthias, Siebert, Nadja, Ruprecht, Klemens, Paul, Friedemann, Collongues, Nicolas, Marignier, Romain, Levy, Michael, Karenfort, Michael, Deppe, Michael, Albrecht, Philipp, Hellwig, Kerstin, Gold, Ralf, Hartung, Hans-Peter, Meuth, Sven G., Kleiter, Ingo, and Aktas, Orhan

Published
2022
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41. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.

Author

Kremer, Stephane, Renard, Felix, Achard, Sophie, Lana-Peixoto, Marco A, Palace, Jacqueline, Asgari, Nasrin, Klawiter, Eric C, Tenembaum, Silvia N, Banwell, Brenda, Greenberg, Benjamin M, Bennett, Jeffrey L, Levy, Michael, Villoslada, Pablo, Saiz, Albert, Fujihara, Kazuo, Chan, Koon Ho, Schippling, Sven, Paul, Friedemann, Kim, Ho Jin, de Seze, Jerome, Wuerfel, Jens T, Guthy-Jackson Charitable Foundation (GJCF) Neuromyelitis Optica (NMO) International Clinical Consortium and Biorepository, Cabre, Philippe, Marignier, Romain, Tedder, Thomas, van Pelt, Danielle, Broadley, Simon, Chitnis, Tanuja, Wingerchuk, Dean, Pandit, Lekha, Leite, Maria Isabel, Apiwattanakul, Metha, Kleiter, Ingo, Prayoonwiwat, Naraporn, Han, May, Hellwig, Kerstin, van Herle, Katja, John, Gareth, Hooper, D Craig, Nakashima, Ichiro, Sato, Douglas, Yeaman, Michael R, Waubant, Emmanuelle, Zamvil, Scott, Stüve, Olaf, Aktas, Orhan, Smith, Terry J, Jacob, Anu, and O'Connor, Kevin

Subjects
Guthy-Jackson Charitable Foundation (GJCF) Neuromyelitis Optica (NMO) International Clinical Consortium and Biorepository, Humans, Neuromyelitis Optica, Magnetic Resonance Imaging, Clinical Trials as Topic, Diffusion Tensor Imaging, Neurosciences, Clinical Research, Brain Disorders, Biomedical Imaging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Neurological, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.

Published
2015

48. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

Author

Correale, Jorge, Caride, Alejandro, Deri, Norma H., Ballario, Carlos, Broadley, Simon, Kneebone, Chris, Barnett, Michael, Pollard, John, Hodgkinson, Suzanne, Kermode, Allan, Macdonell, Richard, King, John, Butzkueven, Helmut, Lechner-Scott, Jeannette, Saines, Noel, Slee, Mark, Plummer, Chris, Willekens, Barbara, Vanopdenbosch, Ludo, Belachew, Shibeshih, Phan-Ba, Rémy, Delvaux, Valérie, Bissay, Veronique, Debruyne, Jan, Decoo, Danny, Crols, Roeland, Symons, Anoek, Nagels, Guy, Van Pesch, Vincent, Sindic, Christian, Dubois, Benedicte, Medaer, Robert, D'Hooghe, Marie, Guillaume, Daniel, De Smet, Eric, Seeldrayers, Pierrette, Lysandropoulos, Andreas, Vokaer, Mathieu, Geens, Karine, Willems, Christina, Denayer, Pierre, Bureau, Michel, Retif, Cecile, Dupuis, Michel, Bouquiaux, Olivier, Vanderdonckt, Patrick, van Landegem, William, Caekebeke, Jo, Van Ingelghem, Erwin, Peeters, Katelijne, Gerard, Pascale, de Noordhout, Alain Maertens, Desfontaines, Philippe, Urbain, Etienne, Declercq, Inge, Van Wijmeersch, Bart, Vanroose, Erwin, Wibail, Alain, Barthomolé, Emmanuel, Ursell, Melanie, Sweet, Margaret Elizabeth, Howse, David, Jichici, Draga, Shawush, Melad, Namaka, Mike, Traboulsee, Anthony, Hashimoto, Stan, Lo, Raymond, Marchetti, Paul, Lapierre, Yves, Jacques, Francois, MacLean, Gregg, Bhan, Virender, Duquette, Pierre, Stewart, Bradley, Paulseth, John, Kremenchutzky, Marcelo, Vorobeychik, Galina, O'Connor, Paul, Grand'Maison, François, Havrdova, Eva, Meluzinová, Eva, Valis, Martin, Talab, Radomír, Stourac, Pavel, Zapletalová, Olga, Dufek, Michal, Sládková, Vladimíra, Novotna, Alena, Vancurová, Romana, Lhotaková, Libuse, Fiedler, Jiri, Vachova, Marta, Dolezil, David, Stetkarova, Ivana, Rehankova, Adela, Psenica, Petr, Ulehlova, Veronika, Feketova, Sona, Skoda, Ondrej, Färkkilä, Markus, Taneli, Sarasoja, Koivisto, Keijo, Seppä, Juha Matti, Airas, Laura, Elovaara, Irina, Hartikainen, Päivi, Pirttila, Tuula, Louchart, Pierre, Ille, Olivier, Thenint, Jean philippe, Godet, Etienne, Vioud, Marcel Maillet, Colamarino, Renato, Gugenheim, Michel, Grimaud, Jerome, Kopf, Audrey, Billy, Christophe, Huttin, Bernard, Borsotti, Jean paul, Devos, Philippe, Kendjuo, Jean bertin N, Verier, Albert, Chapuis, Stephane, Daluzeau, Nathalie, Angibaud, Gilles, Uriot, Marie-Sylvie Artaud, Ziegler, François, Sellal, François, Moulignier, Antoine, Lavenu, Isabelle, Ismail, Samir, Devy, Richard, Suceveanu, Manuel, Wagner, Marc, Marcel, Sebastien, Derouiche, Faycal, Mostoufizadehghalamfarsa, Sohrab, Delalande, Sophie, Ruggieri, Irene, Van Nieuwenhuyse, Catherine Bossu, Nifle, Chantal, Ondze, Basile, Vasilescu, Carmen Gurau, Vongsouthi, Cyrille, Coustans, Marc, Anne, Olivier, Amevigbe, Josephine, Servan, Jerome, Merienne, Marc, Eck, Philippe, Berroir, Stephane, Busson, Philippe, Barroso, Bruno, Larrieu, Jean-Marc, Giendaj, Catherine Louvet, Malkoun, Imad, Hautecoeur, Patrick, Kwiatkowski, Arnaud, Pouliquen, Andre, Garrigues, Guillaume, Delerue, Olivier, Giraud, Pierric, Gere, Julien, Vaunaize, Jean, Dereeper, Olivier, Seiller, Nicolas, Alsassa, Roger, Vlaicu, Mihaela, Neuville, Veronique, Faucheux, Jean Marc, Bernady, Patricia, Fanjaud, Guy, Viallet, François, Schroeter, Michael, Schlemilch-Paschen, Sylke, Lange, Thomas, Bohr, Kin-Arno, Jendroska, Klaus, Rehkopf, Elisabeth, Bergmann, Arnfin, Kleinschnitz, Christoph, Postert, Thomas, Scholz, Peter, Mauz, Uwe, Stratmann, Hubert, Siefjediers, Veneta, Prantl, Martin, Gehring, Klaus, Zellner, Ruth, Junge, Kathrin, Zellner, Anton, Bacay, Valerina, Schlegel, Eugen, Polzer, Udo, Strauss, Erik, Link, Andreas, Stenzel, Christoph, Freidel, Matthias, Drews, Joachim, Neudert, Christian, Schmitz, Frank, Jaeger, Joachim, Masri, Said, Heuberger, Wolfgang, Trausch, Beate, Ruhnke, Oliver, Scarel, Serena, Bach, Kathlen, Ernst, Michael, Landefeld, Harald, Richter, Nils, Schmidt, Stephan, Krause, Michaela, Dressel, Alezander, Ruth, Roland, Anvari, Kerstin, Gossling, Jens, Schenk, Christoph, Tiedge, Oliver, Bode, Lutz, Eder, Hans-Thomas, Pfeffer, Oliver, Krug, Reinhard, Lassek, Christoph, Fleischer, Eberhard, Meuth, Sven, Klotz, Luisa Hildegard, Peglau, Ines, Kukowski, Borries, Herting, Birgit, Guthke, Kersten, Schierenbeck, Jurgen, Brockmeier, Bernd, Albrecht, Holger, Wuttke, Matthias, Augspach-Hofmann, Regine, Gunther, Stefan, Redbrake, Martin, Franke, Christian, Buchner, Klaus, Gratz, Thomas, Horn, Rolf, Doemges, Frank, Schreiber, Martin, Brosch, Thomas, Horn, Markus, Kittlitz, Matthias, Vulturius, Gabriele, Hinse, Paul, Malessa, Rolf, Wiehler, Stephan, Katsarava, Zaza, Kastrup, Oliver, Kausch, Ulrich, Gullekes, Martin, Fickinger, Markus, Wenzel, Wilhelm, Botefur, Ingolf C., Reifschneider, Gerd, Rauer, Sebastian, Lang, Michael, Harms, Lutz, Eckhardt, Ulrich, Cursiefen, Simone, Linker, Ralf, Angstwurm, Klemens, Haas, Judith, Schuetze, Ivo, Rohm, Eva, Stienker-Fisse, H., Sailer, Michael, Bohringer, Johannes, Maurer, Mathias, Bause, Eberhard, Wersching, Ronald, Dachsel, Reinhardt, Domke, Sylke, Hoffman, Frank, Tackenberg, Bjorn, Roch, Kerstin, Ziebold, Uwe, Kallmann, Boris, Buehler, Bernhard, Faiss, Judith, Faiss, Juergen, Schimrigk, Sebastian, Menges, Christian, Knop, Karl Christian, Koehler, Wolfgang, Siever, Arno, Bufler, Johannes, Gramsl, Georg, Kuhnler, Benedicta, Maschke, Matthias, Stogbauer, Florian, Staude, Lisa, Bethke, Florian, Bitsch, Andreas, Harmjanz, Arndt D., Windsheimer, Jorg, Kieseier, Bernd C., Berkenfeld, Ralf, Tumani, Hayrettin, Kirsch, Michael, Wildemann, Brigitte, Daniels, Regina, Gottwald, Klaus, Elias, Wolfgang-Gerhard, Hoffmann, Olaf, Schwab, Matthias, Pilz, Christopher, Klostermann, Fabian, Hellwig, Kerstin, Berthele, Achim, Bayas, Antonios, Molitor, Daniel, Grothe, Christoph, Wagner, Bert, Karageorgiou, Klimentini, Mitsikostas, Dimosthenis, Kodounis, Antonios, Plaitakis, Andreas, Papadimitriou, Alexandros, Grigoriadis, Nikolaos, Vlaikidis, Nikolaos, Koutlas, Evaggelos, Kyritsis, Athanassios, Papathanassopoulos, Panagiotis, Makris, Nikolaos, Tavernarakis, Antonios, Scarpini, Elio, Montanari, Enrico, Marrosu, Maria Giovanna, Trojano, Maria, Amato, Maria Pia, Rottoli, Mariarosa, Lugaresi, Alessandra, Florio, Ciro, Gasperini, Claudio, Grimaldi, Luigi, Millefiorini, Enrico, Koudriavtseva, Tatiana, Perla, Franco, Mantegazza, Renato, Bertolotto, Antonio, Ghezzi, Angelo, Aguilar, Sandra Quinones, Eisenberg, Eli Skromne, Lopez, Leondardo Llamas, Estudillo, Rocio Marquez, Schrijver, H.M., Wittebol, M.C., Baart, J.C., van Golde, A.E.L., Hengstman, G.J.D., Pop, P.H.M., Bos (Geldrop), M., Medaer, R., Schyns-Soeterboek, Angelique, van der Zwart, A., van Diepen, A.J.H., Verheul, G.A.M., Verhagen, W.I.M., Bos (Helmond), M., Witjes, R.J.G.M., Sinnige, L.G.F., van Munster, E.Th.L., Sanders, E.A.C.M., van Dijl, Ron, Hupperts, R.M.M., Frequin, S.T.F.M., Visser, L.H., Henselmans, J.M.L., Moll, J.W.B., Midgard, Rune, Myhr, Kjell Morten, Edland, Astrid, Telstad, Wenche, Hognestad, Tone, Lund, Christian, Hovdal, Harald, Kamaljit, Kaur, Schepel, Jan, Hogenesch, Roelfien Ida, Schüler, Stephan, Odeh, Francis, Alstadhaug, Karl B., Korsgaard, Olav, Farbu, Elisabeth, Ingvaldsen, Teis Barclay, Soares (SCO), Diana, Rente, José, Guerra, José Manuel Costa, Morganho, Armando, Leitão, António, de Sá, João, Sá, Maria José, Marques, Pinto, Veloso, Mário, Baptista, Miguel Viana, Szilasiová, Jarmila, Copikova-Cudrakova, Daniela, Prochazkova, Lubica, Klimová, Eleonóra, Donath, Vladimir, Brozman, Miroslav, Ramo, Cristina, Ruiz, Domingo Pérez, Hernández, Carmen Calles, Sola, María Eugenia Marzo, Moro, Roberto Suarez, Vidal, Jose Antonio, Rodríguez, Ana Belén Caminero, Ozaeta, Gisela Martin, Nadal, Jordi Batlle, Esquide, Amaya Alvarez de Arcaya, Urtaza, Javier Olascoaga, Martínez-Yélamos, Sergio, Arbizu, Txomin, Torrenta, Lluis Ramio i, Boggild, Mike, Wilson, Martin, Al-Araji, Adnan, Nicholas, Richard, Harrower, Timothy, Redmond, Ian, Wolf, Tilo, Osei-Bonsu, Michael, Mazibrada, Gordon, Rog, David, Cottrell, David, Constantinescu, Cris, Gray, Orla, Belhag, Mohamed, Shehu, Abdullah, Rashid, Waqar, Duddy, Martin, Kappos, Ludwig, Wiendl, Heinz, Spelman, Tim, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, and Koendgen, Harold

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2018
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