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1. Space radiation measurements during the Artemis I lunar mission

Author

George, Stuart P., Gaza, Ramona, Matthiä, Daniel, Laramore, Diego, Lehti, Jussi, Campbell-Ricketts, Thomas, Kroupa, Martin, Stoffle, Nicholas, Marsalek, Karel, Przybyla, Bartos, Abdelmelek, Mena, Aeckerlein, Joachim, Bahadori, Amir A., Barzilla, Janet, Dieckmann, Matthias, Ecord, Michael, Egeland, Ricky, Eronen, Timo, Fry, Dan, Jones, Bailey H., Hellweg, Christine E., Houri, Jordan, Hirsh, Robert, Hirvonen, Mika, Hovland, Scott, Hussein, Hesham, Johnson, A. Steve, Kasemann, Moritz, Lee, Kerry, Leitgab, Martin, McLeod, Catherine, Milstein, Oren, Pinsky, Lawrence, Quinn, Phillip, Riihonen, Esa, Rohde, Markus, Rozhdestvenskyy, Sergiy, Saari, Jouni, Schram, Aaron, Straube, Ulrich, Turecek, Daniel, Virtanen, Pasi, Waterman, Gideon, Wheeler, Scott, Whitman, Kathryn, Wirtz, Michael, Vandewalle, Madelyn, Zeitlin, Cary, Semones, Edward, and Berger, Thomas

Published
2024
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2. BioMoon: a concept for a mission to advance space life sciences and astrobiology on the Moon

Author

Cockell, Charles S., Green, David A., Caplin, Nicol, Grenouilleau, Jessica, McDonald, Francesca E., Calvaruso, Marco, Billi, Daniela, Cullen, David C., Davey, Matthew P., De Micco, Veronica, Elsaesser, Andreas, Etheridge, Timothy, Gläßer, Christine, Hellweg, Christine E., Ilea, Crina S., Lecocq, Antoine, Leys, Natalie, Martin-Torres, Javier, Nazarious, Miracle, Pacelli, Claudia, Przybyla, Cyrille, Rabbow, Elke, Brown, Kate Robson, Soria-Salinas, Alvaro, Szewczyk, Nathaniel, Tinganelli, Walter, Tranfield, Erin M., de Vera, Jean-Pierre, and Verseux, Cyprien

Published
2024
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3. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R. G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024
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4. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024
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5. Space Radiobiology

Author

Hellweg, Christine Elisabeth, Arena, Carmen, Baatout, Sarah, Baselet, Bjorn, Beblo-Vranesevic, Kristina, Caplin, Nicol, Coos, Richard, Da Pieve, Fabiana, De Micco, Veronica, Foray, Nicolas, Hespeels, Boris, Heuskin, Anne-Catherine, Kronenberg, Jessica, Milojevic, Tetyana, Miranda, Silvana, Moris, Victoria, Penninckx, Sébastien, Radstake, Wilhelmina E., Rehnberg, Emil, Rettberg, Petra, Tabury, Kevin, Van Doninck, Karine, Van Hoey, Olivier, Vogin, Guillaume, Socol, Yehoshua, and Baatout, Sarah, editor

Published
2023
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6. The Lunar Lander Neutron and Dosimetry (LND) Experiment on Chang'E 4

Author

Wimmer-Schweingruber, Robert F., Yu, Jia, Böttcher, Stephan I., Zhang, Shenyi, Burmeister, Sönke, Lohf, Henning, Guo, Jingnan, Xu, Zigong, Schuster, Björn, Seimetz, Lars, von Forstner, Johan L. Freiherr, Ravanbakhsh, Ali, Knierim, Violetta, Kolbe, Stefan, Woyciechowsky, Hauke, Kulkarni, Shrinivasrao R., Yuan, Bin, Shen, Guohong, Wang, Chunqing, Chang, Zheng, Berger, Thomas, Hellweg, Christine E., Matthiä, Daniel, Hou, Donghui, Knappmann, Alke, Büschel, Charlotte, Hou, Xufeng, Ren, Baoguo, and Fu, Qiang

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Chang'E 4 is the first mission to the far side of the Moon and consists of a lander, a rover, and a relay spacecraft. Lander and rover were launched at 18:23 UTC on December 7, 2018 and landed in the von K\'arm\'an crater at 02:26 UTC on January 3, 2019. Here we describe the Lunar Lander Neutron \& Dosimetry experiment (LND) which is part of the Chang'E 4 Lander scientific payload. Its chief scientific goal is to obtain first active dosimetric measurements on the surface of the Moon. LND also provides observations of fast neutrons which are a result of the interaction of high-energy particle radiation with the lunar regolith and of their thermalized counterpart, thermal neutrons, which are a sensitive indicator of subsurface water content., Comment: 38 pages, submitted to Space Science Reviews

Published
2020
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7. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023
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9. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Published
2024

10. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, Szewczyk, Nathaniel, Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, and Szewczyk, Nathaniel

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

11. General Introduction

Author

Hellweg, Christine E., Matthiä, Daniel, Berger, Thomas, Baumstark-Khan, Christa, Ruyters, Günter, Series Editor, Braun, Markus, Series Editor, Hellweg, Christine E., Berger, Thomas, Matthiä, Daniel, and Baumstark-Khan, Christa

Published
2020
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12. Radiation Risk Assessment

Author

Hellweg, Christine E., Matthiä, Daniel, Berger, Thomas, Baumstark-Khan, Christa, Ruyters, Günter, Series Editor, Braun, Markus, Series Editor, Hellweg, Christine E., Berger, Thomas, Matthiä, Daniel, and Baumstark-Khan, Christa

Published
2020
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13. Space Radiation Countermeasures

Author

Hellweg, Christine E., Matthiä, Daniel, Berger, Thomas, Baumstark-Khan, Christa, Ruyters, Günter, Series Editor, Braun, Markus, Series Editor, Hellweg, Christine E., Berger, Thomas, Matthiä, Daniel, and Baumstark-Khan, Christa

Published
2020
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14. Challenges for Exploratory Missions

Author

Hellweg, Christine E., Matthiä, Daniel, Berger, Thomas, Baumstark-Khan, Christa, Ruyters, Günter, Series Editor, Braun, Markus, Series Editor, Hellweg, Christine E., Berger, Thomas, Matthiä, Daniel, and Baumstark-Khan, Christa

Published
2020
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15. Radiation in Space: The Physics

Author

Hellweg, Christine E., Matthiä, Daniel, Berger, Thomas, Baumstark-Khan, Christa, Ruyters, Günter, Series Editor, Braun, Markus, Series Editor, Hellweg, Christine E., Berger, Thomas, Matthiä, Daniel, and Baumstark-Khan, Christa

Published
2020
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16. Radiation in Space: The Biology

Author

Hellweg, Christine E., Matthiä, Daniel, Berger, Thomas, Baumstark-Khan, Christa, Ruyters, Günter, Series Editor, Braun, Markus, Series Editor, Hellweg, Christine E., Berger, Thomas, Matthiä, Daniel, and Baumstark-Khan, Christa

Published
2020
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17. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R G, Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J, Willis, Craig R G, Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?" The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

18. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, Monici, Monica, Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024

19. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024

21. Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.

Author

Norbury, John W, Schimmerling, Walter, Slaba, Tony C, Azzam, Edouard I, Badavi, Francis F, Baiocco, Giorgio, Benton, Eric, Bindi, Veronica, Blakely, Eleanor A, Blattnig, Steve R, Boothman, David A, Borak, Thomas B, Britten, Richard A, Curtis, Stan, Dingfelder, Michael, Durante, Marco, Dynan, William S, Eisch, Amelia J, Robin Elgart, S, Goodhead, Dudley T, Guida, Peter M, Heilbronn, Lawrence H, Hellweg, Christine E, Huff, Janice L, Kronenberg, Amy, La Tessa, Chiara, Lowenstein, Derek I, Miller, Jack, Morita, Takashi, Narici, Livio, Nelson, Gregory A, Norman, Ryan B, Ottolenghi, Andrea, Patel, Zarana S, Reitz, Guenther, Rusek, Adam, Schreurs, Ann-Sofie, Scott-Carnell, Lisa A, Semones, Edward, Shay, Jerry W, Shurshakov, Vyacheslav A, Sihver, Lembit, Simonsen, Lisa C, Story, Michael D, Turker, Mitchell S, Uchihori, Yukio, Williams, Jacqueline, and Zeitlin, Cary J

Subjects
Radiobiology, Cosmic Radiation, Research, United States National Aeronautics and Space Administration, Laboratories, United States, Galactic cosmic ray simulation, Space radiation, Galactic cosmic ray simulationat
Abstract

Most accelerator-based space radiation experiments have been performed with single ion beams at fixed energies. However, the space radiation environment consists of a wide variety of ion species with a continuous range of energies. Due to recent developments in beam switching technology implemented at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), it is now possible to rapidly switch ion species and energies, allowing for the possibility to more realistically simulate the actual radiation environment found in space. The present paper discusses a variety of issues related to implementation of galactic cosmic ray (GCR) simulation at NSRL, especially for experiments in radiobiology. Advantages and disadvantages of different approaches to developing a GCR simulator are presented. In addition, issues common to both GCR simulation and single beam experiments are compared to issues unique to GCR simulation studies. A set of conclusions is presented as well as a discussion of the technical implementation of GCR simulation.

Published
2016

22. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.

Published
2023

23. NF-κB in the Radiation Response of A549 Non-Small Cell Lung Cancer Cells to X-rays and Carbon Ions under Hypoxia.

Author

Nisar, Hasan, Sanchidrián González, Paulina Mercedes, Labonté, Frederik M., Schmitz, Claudia, Roggan, Marie Denise, Kronenberg, Jessica, Konda, Bikash, Chevalier, François, and Hellweg, Christine E.

Subjects
NON-small-cell lung carcinoma, LINEAR energy transfer, CANCER cells, RADIOBIOLOGY, HYPOXEMIA, IRRADIATION, X-rays
Abstract

Cellular hypoxia, detectable in up to 80% of non-small cell lung carcinoma (NSCLC) tumors, is a known cause of radioresistance. High linear energy transfer (LET) particle radiation might be effective in the treatment of hypoxic solid tumors, including NSCLC. Cellular hypoxia can activate nuclear factor κB (NF-κB), which can modulate radioresistance by influencing cancer cell survival. The effect of high-LET radiation on NF-κB activation in hypoxic NSCLC cells is unclear. Therefore, we compared the effect of low (X-rays)- and high (12C)-LET radiation on NF-κB responsive genes' upregulation, as well as its target cytokines' synthesis in normoxic and hypoxic A549 NSCLC cells. The cells were incubated under normoxia (20% O2) or hypoxia (1% O2) for 48 h, followed by irradiation with 8 Gy X-rays or 12C ions, maintaining the oxygen conditions until fixation or lysis. Regulation of NF-κB responsive genes was evaluated by mRNA sequencing. Secretion of NF-κB target cytokines, IL-6 and IL-8, was quantified by ELISA. A greater fold change increase in expression of NF-κB target genes in A549 cells following exposure to 12C ions compared to X-rays was observed, regardless of oxygenation status. These genes regulate cell migration, cell cycle, and cell survival. A greater number of NF-κB target genes was activated under hypoxia, regardless of irradiation status. These genes regulate cell migration, survival, proliferation, and inflammation. X-ray exposure under hypoxia additionally upregulated NF-κB target genes modulating immunosurveillance and epithelial-mesenchymal transition (EMT). Increased IL-6 and IL-8 secretion under hypoxia confirmed NF-κB-mediated expression of pro-inflammatory genes. Therefore, radiotherapy, particularly with X-rays, may increase tumor invasiveness in surviving hypoxic A549 cells. [ABSTRACT FROM AUTHOR]

Published
2024
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26. General Introduction

Author

Hellweg, Christine E., primary, Matthiä, Daniel, additional, Berger, Thomas, additional, and Baumstark-Khan, Christa, additional

Published
2020
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29. Radiation Risk Assessment

Author

Hellweg, Christine E., primary, Matthiä, Daniel, additional, Berger, Thomas, additional, and Baumstark-Khan, Christa, additional

Published
2020
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34. Human gut microbiome and metabolite dynamics under simulated microgravity

Author

Ramos-Nascimento, Ana, primary, Grenga, Lucia, additional, Haange, Sven-Bastiaan, additional, Himmelmann, Alexandra, additional, Arndt, Franca Sabine, additional, Ly, Yen-Tran, additional, Miotello, Guylaine, additional, Pible, Olivier, additional, Jehmlich, Nico, additional, Engelmann, Beatrice, additional, von Bergen, Martin, additional, Mulder, Edwin, additional, Frings-Meuthen, Petra, additional, Hellweg, Christine Elisabeth, additional, Jordan, Jens, additional, Rolle-Kampczyk, Ulrike, additional, Armengaud, Jean, additional, and Moeller, Ralf, additional

Published
2023
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38. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, Monici, Monica, Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, and Monici, Monica

Published
2023

39. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., Monici, Monica, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023

40. Towards sustainable human space exploration—priorities for radiation research to quantify and mitigate radiation risks

Author

Fogtman, Anna; https://orcid.org/0000-0002-5331-7840, Baatout, Sarah; https://orcid.org/0000-0001-8110-751X, Baselet, Bjorn, Berger, Thomas; https://orcid.org/0000-0003-3319-5740, Hellweg, Christine E; https://orcid.org/0000-0002-2223-3580, Jiggens, Piers, La Tessa, Chiara, Narici, Livio, Nieminen, Petteri, Sabatier, Laure, Santin, Giovanni, Schneider, Uwe; https://orcid.org/0000-0002-6403-204X, Straube, Ulrich, Tabury, Kevin; https://orcid.org/0000-0002-8004-3718, Tinganelli, Walter, Walsh, Linda; https://orcid.org/0000-0001-7399-9191, Durante, Marco; https://orcid.org/0000-0002-4615-553X, Fogtman, Anna; https://orcid.org/0000-0002-5331-7840, Baatout, Sarah; https://orcid.org/0000-0001-8110-751X, Baselet, Bjorn, Berger, Thomas; https://orcid.org/0000-0003-3319-5740, Hellweg, Christine E; https://orcid.org/0000-0002-2223-3580, Jiggens, Piers, La Tessa, Chiara, Narici, Livio, Nieminen, Petteri, Sabatier, Laure, Santin, Giovanni, Schneider, Uwe; https://orcid.org/0000-0002-6403-204X, Straube, Ulrich, Tabury, Kevin; https://orcid.org/0000-0002-8004-3718, Tinganelli, Walter, Walsh, Linda; https://orcid.org/0000-0001-7399-9191, and Durante, Marco; https://orcid.org/0000-0002-4615-553X

Abstract

Human spaceflight is entering a new era of sustainable human space exploration. By 2030 humans will regularly fly to the Moon’s orbit, return to the Moon’s surface and preparations for crewed Mars missions will intensify. In planning these undertakings, several challenges will need to be addressed in order to ensure the safety of astronauts during their space travels. One of the important challenges to overcome, that could be a major showstopper of the space endeavor, is the exposure to the space radiation environment. There is an urgent need for quantifying, managing and limiting the detrimental health risks and electronics damage induced by space radiation exposure. Such risks raise key priority topics for space research programs. Risk limitation involves obtaining a better understanding of space weather phenomena and the complex radiation environment in spaceflight, as well as developing and applying accurate dosimetric instruments, understanding related short- and long-term health risks, and strategies for effective countermeasures to minimize both exposure to space radiation and the remaining effects post exposure. The ESA/SciSpacE Space Radiation White Paper identifies those topics and underlines priorities for future research and development, to enable safe human and robotic exploration of space beyond Low Earth Orbit.

Published
2023

41. Galactic cosmic ray simulation at the NASA Space Radiation Laboratory

Author

Norbury, John W., Schimmerling, Walter, Slaba, Tony C., Azzam, Edouard I., Badavi, Francis F., Baiocco, Giorgio, Benton, Eric, Bindi, Veronica, Blakely, Eleanor A., Blattnig, Steve R., Boothman, David A., Borak, Thomas B., Britten, Richard A., Curtis, Stan, Dingfelder, Michael, Durante, Marco, Dynan, William S., Eisch, Amelia J., Robin Elgart, S., Goodhead, Dudley T., Guida, Peter M., Heilbronn, Lawrence H., Hellweg, Christine E., Huff, Janice L., Kronenberg, Amy, La Tessa, Chiara, Lowenstein, Derek I., Miller, Jack, Morita, Takashi, Narici, Livio, Nelson, Gregory A., Norman, Ryan B., Ottolenghi, Andrea, Patel, Zarana S., Reitz, Guenther, Rusek, Adam, Schreurs, Ann-Sofie, Scott-Carnell, Lisa A., Semones, Edward, Shay, Jerry W., Shurshakov, Vyacheslav A., Sihver, Lembit, Simonsen, Lisa C., Story, Michael D., Turker, Mitchell S., Uchihori, Yukio, Williams, Jacqueline, and Zeitlin, Cary J.

Published
2016
Full Text
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46. Radiation Type- and Dose-Specific Transcriptional Responses across Healthy and Diseased Mammalian Tissues

Author

Sagkrioti, Eftychia, primary, Biz, Gökay Mehmet, additional, Takan, Işıl, additional, Asfa, Seyedehsadaf, additional, Nikitaki, Zacharenia, additional, Zanni, Vassiliki, additional, Kars, Rumeysa Hanife, additional, Hellweg, Christine E., additional, Azzam, Edouard I., additional, Logotheti, Stella, additional, Pavlopoulou, Athanasia, additional, and Georgakilas, Alexandros G., additional

Published
2022
Full Text
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50. Streamlining Culture Conditions for the Neuroblastoma Cell Line SH-SY5Y: A Prerequisite for Functional Studies

Author

Feles, Sebastian, Overath, Christian, Reichardt, Sina, Diegeler, Sebastian, Schmitz, Claudia, Kronenberg, Jessica, Baumstark-Khan, Christa, Hemmersbach, Ruth, Hellweg, Christine Elisabeth, and Liemersdorf, Christian

Subjects
neuroscience, neuroblastoma, cell culture, proliferation, cultivation techniques, in vitro methods, morphology, characterization, SH-SY5Y
Published
2022

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