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176 results on '"Heller, Wolf-Dieter"'

6. Passive Smoking and Lung Cancer

Author

Lee, Peter, Scherer, Gerhard, Heller, Wolf-Dieter, Nyberg, Fredrik, Pershagen, Göran, Hackshaw, A. K., Law, M. R., and Wald, N. J.

Published
1998

11. An Inter-Laboratory Comparison for the Urinary Acrolein Biomarker 3-Hydroxypropyl-Mercapturic Acid (3-HPMA)

Author

Scherer Gerhard, Heller Wolf-Dieter, McEwan Michael, Göen Thomas, Joza Peter, Liu Nan, Newland Kirk, Schettgen Thomas, Wang Sheng, Sohn Hyung-Ok, Troude Valerie, Yuki Dai, Zheng Saijing, and Zhou Guojun

Subjects
Inter-laboratory comparison, intra-laboratory variation, lcsh:SB1-1110, 3-hydroxypropyl-mercapturic acid (3-HPMA), inter-laboratory variation, repeatability, lcsh:Plant culture, reproducibility
Abstract

An inter-laboratory comparison study on the acrolein biomarker of exposure 3-hydroxypropyl-mercapturic acid (3-HPMA) with 12 laboratories from 7 globally distributed countries was performed. The laboratories received coded triplicates of 4 spiked and lyophilized urine samples (LU, 12 samples) as well as 5 authentic urine pool samples (PU, 15 samples) covering the 3-HPMA concentration range from background (non-smoking) to heavy smoking levels for analysis by using their own (in-house) analytical method. All laboratories applied liquid chromatography with tandem mass spectrometry (LC-MS/MS), with most of them (10 of 12) using solid phase extraction (SPE) as sample work-up procedure. The intra-laboratory variation (indicating repeatability) was determined by calculating the standard deviation (sr) and the coefficient of variation (CVr) of the triplicates, whereas the inter-laboratory variation (indicating reproducibility) was determined by calculating the standard deviation between laboratories (sR) and the corresponding coefficient of variation (CVR). After removal of outlier samples or laboratories, the mean CVr values for LU and PU test samples ranged from 2.1–3.6% (mean: 2.8%) and 2.4–3.7% (mean: 3.3%), respectively, indicating good repeatability for the determination of 3-HPMA in both sample types. CVR for LU and PU test samples ranged from 9.1–31.9% (mean: 18.8%) and 13.9–27.0% (mean: 18.5%), respectively, indicating limited reproducibility in 3-HPMA analysis for both sample types. Re-calculation of the PU results by applying an embedded calibration (EC), derived from the reported peak areas for the LU test samples, somewhat improved the CVR values (range: 9.6–28.8%, mean: 16.7%).

Published
2017

15. Nichtparametrische Testverfahren

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1980
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16. Klassische Testverfahren

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1980
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17. Testen von Hypothesen

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1980
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18. Bereichsschätzung

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1980
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19. Schätzen von Parametern

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1980
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20. Stichproben

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1980
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22. Zweidimensionale Zufallsvariablen

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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23. Spezielle Verteilungen

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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29. Bedingtheit — Unabhängigkeit

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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30. Einführung

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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31. Statistische Masszahlen

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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32. Eindimensionale Merkmale

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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33. Weitere Masszahlen

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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34. Mehrdimensionale Merkmale

Author

Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, Schriever, Karl-Heinz, Heller, Wolf-Dieter, Lindenberg, Henner, Nuske, Manfred, and Schriever, Karl-Heinz

Published
1979
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42. Schliessende Statistik

Author

Heller, Wolf-Dieter, primary, Lindenberg, Henner, additional, Nuske, Manfred, additional, and Schriever, Karl-Heinz, additional

Published
1980
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44. Beschreibende Statistik

Author

Heller, Wolf-Dieter, primary, Lindenberg, Henner, additional, Nuske, Manfred, additional, and Schriever, Karl-Heinz, additional

Published
1979
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46. An Inter-Laboratory Comparison for the Urinary Acrolein Biomarker 3-Hydroxypropyl-Mercapturic Acid (3-HPMA).

Author

Scherer, Gerhard, Heller, Wolf-Dieter, McEwan, Michael, Göen, Thomas, Joza, Peter, Liu, Nan, Newland, Kirk, Schettgen, Thomas, Wang, Sheng, Sohn, Hyung-Ok, Troude, Valerie, Yuki, Dai, Zheng, Saijing, and Zhou, Guojun

Subjects
*ACROLEIN, *MERCAPTURIC acid, *BIOMARKERS
Abstract

An inter-laboratory comparison study on the acrolein biomarker of exposure 3-hydroxypropyl-mercapturic acid (3-HPMA) with 12 laboratories from 7 globally distributed countries was performed. The laboratories received coded triplicates of 4 spiked and lyophilized urine samples (LU, 12 samples) as well as 5 authentic urine pool samples (PU, 15 samples) covering the 3-HPMA concentration range from background (non-smoking) to heavy smoking levels for analysis by using their own (in-house) analytical method. All laboratories applied liquid chromatography with tandem mass spectrometry (LC-MS/MS), with most of them (10 of 12) using solid phase extraction (SPE) as sample work-up procedure. The intra-laboratory variation (indicating repeatability) was determined by calculating the standard deviation (sr) and the coefficient of variation (CVr) of the triplicates, whereas the inter-laboratory variation (indicating reproducibility) was determined by calculating the standard deviation between laboratories (sR) and the corresponding coefficient of variation (CVR). After removal of outlier samples or laboratories, the mean CVr values for LU and PU test samples ranged from 2.1-3.6% (mean: 2.8%) and 2.4-3.7% (mean: 3.3%), respectively, indicating good repeatability for the determination of 3-HPMA in both sample types. CVR for LU and PU test samples ranged from 9.1-31.9% (mean: 18.8%) and 13.9-27.0% (mean: 18.5%), respectively, indicating limited reproducibility in 3-HPMA analysis for both sample types. Re-calculation of the PU results by applying an embedded calibration (EC), derived from the reported peak areas for the LU test samples, somewhat improved the CVR values (range: 9.6-28.8%, mean: 16.7%). It is concluded that the intra-laboratory variation (repeatability) in the determination of 3-HPMA in urine is in general acceptable in the participating laboratories, while the inter-laboratory variability requires further improvement. The relatively small reduction in the inter-laboratory variability (sR and CVR) by applying an EC suggests that other methodological factors than the standard reference material for 3-HPMA have to be addressed to achieve further improvement in reproducibility. [ABSTRACT FROM AUTHOR]

Published
2017
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