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4. Contributors

Author

Ayan, Sümeyra, primary, Aydin, Mahmud, additional, Ayran, Melih Musa, additional, Balescu, Liliana Marinela, additional, Bedir, Tuba, additional, Bozlar, Michael, additional, Cam, Muhammet Emin, additional, Cerci, Mehmet Halis, additional, Cesur, Sumeyye, additional, Chircov, Cristina, additional, Ciki, B., additional, Çiftçi, Kübra Arancı, additional, Ekren, Nazmi, additional, Ficai, Anton, additional, Guler, Ece, additional, Gunduz, Oguzhan, additional, Guvenc, Yahya, additional, Heljak, Marcin K., additional, Ikram, Hafiza Fakhera, additional, Ilhan, Elif, additional, Ioniță, Daniela-Alina, additional, Kalay, Onur Can, additional, Karademir-Yilmaz, B., additional, Karpat, Fatih, additional, Khandaker, Morshed, additional, Kijeńska-Gawrońska, Ewa, additional, Kivrak, Can, additional, Mahirogullari, Mahir, additional, Musuc, Adina Magdalena, additional, Neacşu, Ionela Andreea, additional, Polat, Elif Beyzanur, additional, Popa, Adrian-Claudiu, additional, Progri, Helga, additional, Sahin, A., additional, Şengör, Mustafa, additional, Sîrmon, Andra-Maria, additional, Stan, George E., additional, Surucu, Serkan, additional, Swieszkowski, Wojciech, additional, Tite, Teddy, additional, Ulag, Songul, additional, Ustundag, Cem Bulent, additional, Vasile, Bogdan Stefan, additional, Yildirim, Ridvan, additional, Yilmazer, Yasemin, additional, Yüce, Celalettin, additional, Yılmaz, Tufan Gürkan, additional, and Yüvrük, Evren, additional

Published
2023
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5. Polymyxin B Peptide Hydrogel Coating: A Novel Approach to Prevent Ventilator-Associated Pneumonia.

Author

Wouters, Milan, Van Moll, Laurence, De Vooght, Linda, Choińska, Emilia, Idaszek, Joanna, Szlązak, Karol, Heljak, Marcin K., Święszkowski, Wojciech, and Cos, Paul

Subjects
ATOMIC force microscopy, VENTILATOR-associated pneumonia, ANTIMICROBIAL peptides, BACTERIAL adhesion, NOSOCOMIAL infections
Abstract

Ventilator-associated pneumonia (VAP) remains one of the most common hospital-acquired infections (HAI). Considering the complicated diagnosis and the lack of effective treatment, prophylactic measures are suggested as the new standard to prevent the disease. Although VAP often manifests a polymicrobial nature, Pseudomonas aeruginosa remains one of the pathogens associated with the highest morbidity and mortality rates within these mechanically ventilated patients. In this paper, we report on the development of an antibacterial hydrogel coating using the polymyxin B (PMB) peptide to prevent bacterial adhesion to the polymeric substrate. We fully characterized the properties of the coating using atomic force microscopy (AFM), scanning electron microscopy (SEM), wettability analyses and Fourier-transform infrared (FTIR) and Raman spectroscopy. Furthermore, several biological assays confirmed the antibacterial and anti-biofilm effect of the tubing for at least 8 days against P. aeruginosa. On top of that, the produced coating is compliant with the requirements regarding cytocompatibility stated in the ISO (International Organization for Standardization) 10993 guidelines and an extended release of PMB over a period of at least 42 days was detected. In conclusion, this study serves as a foundation for peptide-releasing hydrogel formulas in the prevention of VAP. [ABSTRACT FROM AUTHOR]

Published
2024
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