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Honey is a food of great nutritional importance and has always been used for human consumption. The production of honey and other beekeeping products depends on the proper functioning of this extremely important sector, as it has a direct impact on other sectors such as agriculture. The decline in bee colony numbers has been linked, among other factors, to bacterial diseases affecting bees, including American and European foulbrood, and Nosema spp. disease. In this matter, prophylactic or therapeutic use of veterinary drugs in apiculture is common but can lead to their accumulation in bees and in honey. Consumption of contaminated honey can have adverse effects such as allergic or hypersensitivity reactions, carcinogenicity, reproductive effects, and teratogenicity. Commission Regulation (EU) N⍛ 37/2010 sets MRLs for antibiotics in various foods, but these limits are not set for api-products. The lack of harmonized rules has led some countries to set recommended concentrations and minimum performance limits. Nonetheless, to achieve this goal, development of accurate and precise analytical methodologies is crucial. In recent years, the analysis of antibiotics in honey has led to the development of methods in an extensive range of families, including aminoglycosides, amphenicols, lincosamides, macrolides, nitroimidazoles, quinolones, sulfonamides, tetracyclines and nitrofurans. This review work entails an in-depth exploration of occurrence studies, extraction methodologies, and analytical techniques for the determination of antibiotics in apiculture products. It was found that the most used extraction methods include solid-phase extraction, dispersed solid or liquid phase extraction and QuEChERS. Due to the complexity of the honey matrix, samples are often diluted or acidified using McIlvaine buffer, H2O, MeOH, acidified ACN and TCA solution. This is usually followed by a purification step using SPE cartridges or PSA. Golden analytical methodologies include high-performance liquid chromatography coupled to a triple quadrupole mass spectrometer (MS/MS) with Orbitrap or Q-ToF detectors.

Smart city initiatives are being promoted across the world to address major urban challenges, and they all share a common belief in the transformative power of digital technologies. However, the pace of innovation in smart cities seems to be much slower than the rapid and profoundly disruptive transformations brought about by digital innovation in many other domains. To develop new insights about the main causes behind this relatively modest success, this study provides a Systematic Literature Review (SLR) on the connection between major smart city challenges and the essential properties of digital innovation. The review involved the qualitative analysis of 44 research papers reporting on smart city innovation practices and outcomes. The results characterize five major challenge categories for smart city innovation: Strategic vision; Organizational Capabilities and Agility; Technology Domestication; Ecosystem Development; and Transboundary Innovation. This study also explores the connections between these challenges and concrete digital innovation practices in smart city initiatives. The main conclusion is that current innovation practices in smart cities are not properly aligned with what the research literature commonly describes as core properties of digital innovation and that this might be a major cause behind the limited progress in smart city initiatives.

Due to the working conditions imposed by the COVID-19 pandemic, teleworking also known as remote work has witnessed an increase in use, prompting a resurgence of interest in the topic among researchers. This article analyzes the evolution of literature before, during, and after the pandemic, as well as the research foci through an application of the antecedents, decisions, and outcomes framework. A systematic literature review methodology was employed using the evidence from 136 articles from 2016 to 2023. This review is about ‘telework literature in business, management, and accounting areas published in English’. Opportunities are identified for future studies and the findings afford managers with the advantage of understanding the crucial dimensions of telework. The bibliometric analysis revealed the significant impact of the COVID-19 pandemic on the widespread acceptance of teleworking globally, accompanied by a surge in studies on this subject. Additionally, the study provides deeper insights into the progression of teleworking literature since 2016 and organizes the various topics explored in this field.

Motherese has been studied particularly in its prosodic features. The scientific literature has underlined the importance of this type of communication on the infants’ vocal responsiveness. However, we still know little about the role of motherese on preterm infants’ vocal responsiveness. We intend to know the prosodic and communicative characteristics of motherese in preterm dyads and particularly to understand its relationship with the preterm infant’s vocal responsiveness. At NICU, mothers (N = 38) were asked to speak and to sing without words (humming) to their preterm infants in kangaroo care during five periods of three minutes alternating voice and silence, controlling the order effect (silence – speech or humming – silence – humming or speech – silence). A microanalytical study about prosodic and communicative/affectionate features of motherese was performed using ELAN, MAXQDA, and PRAAT software. According to results, tonal contours (sinusoidal, U-shaped and falling) and infants’ vocalizations seem to contribute for preterm dyads’ vocal modulation. A high use of phatic and conative functions, interrogative utterances, infants’ positive aspects, infants designated by affectionate words, and utterances connected with infants' needs were observed. This study contributed to explore the role of the communicative/affectionate and prosodic features of the motherese on preterm infants’ vocal responsiveness during the kangaroo care in NICU. Still, more studies are needed to deepen these preliminary results.

Introduction Few community-based interventions addressing the transmission control and clinical management of COVID-19 cases have been reported, especially in poor urban communities from low-income and middle-income countries. Here, we analyse the impact of a multicomponent intervention that combines community engagement, mobile surveillance, massive testing and telehealth on COVID-19 cases detection and mortality rates in a large vulnerable community (Complexo da Maré) in Rio de Janeiro, Brazil.Methods We performed a difference-in-differences (DID) analysis to estimate the impact of the multicomponent intervention in Maré, before (March–August 2020) and after the intervention (September 2020 to April 2021), compared with equivalent local vulnerable communities. We applied a negative binomial regression model to estimate the intervention effect in weekly cases and mortality rates in Maré.Results Before the intervention, Maré presented lower rates of reported COVID-19 cases compared with the control group (1373 vs 1579 cases/100 000 population), comparable mortality rates (309 vs 287 deaths/100 000 population) and higher case fatality rates (13.7% vs 12.2%). After the intervention, Maré displayed a 154% (95% CI 138.6% to 170.4%) relative increase in reported case rates. Relative changes in reported death rates were −60% (95% CI −69.0% to −47.9%) in Maré and −28% (95% CI −42.0% to −9.8%) in the control group. The case fatality rate was reduced by 77% (95% CI −93.1% to −21.1%) in Maré and 52% (95% CI −81.8% to −29.4%) in the control group. The DID showed a reduction of 46% (95% CI 17% to 65%) of weekly reported deaths and an increased 23% (95% CI 5% to 44%) of reported cases in Maré after intervention onset.Conclusion An integrated intervention combining communication, surveillance and telehealth, with a strong community engagement component, could reduce COVID-19 mortality and increase case detection in a large vulnerable community in Rio de Janeiro. These findings show that investment in community-based interventions may reduce mortality and improve pandemic control in poor communities from low-income and middle-income countries.

Este artigo tem como foco as dinâmicas políticas e sociais envolvidas no processo de institucionalização do Programa Ecoforte – Redes de Agroecologia, Extrativismo e Produção Orgânica, no âmbito da Política Nacional de Agroecologia e Produção Orgânica – Pnapo. A criação desta política pública encontra-se associada a uma trajetória mais ampla de interações estabelecidas entre agentes governamentais e organizações sociais, que possibilitou que a agroecologia ampliasse seu espaço de legitimidade como um referencial de política pública. Considerando as inovações conceituais e operacionais incorporadas ao Ecoforte, especial atenção foi dedicada aos processos participativos envolvidos na instrumentação do programa, mobilizando perspectivas de análise desenvolvidas pela sociologia francesa e que questionam a neutralidade dos instrumentos de políticas públicas, chamando a atenção para os efeitos desses dispositivos no ordenamento das relações estabelecidas pelo Estado com seus públicos. Destaca-se que a incorporação pelo Ecoforte de conceitos e modos de operação desenvolvidos em um processo de diálogo com as organizações sociais permitiu ao programa uma melhor adaptação à diversidade e à multilinearidade dos processos de transição agroecológica vivenciados nos territórios. Os resultados de pesquisa aqui apresentados foram gerados através de um projeto de pesquisa-ação coordenado pela Articulação Nacional de Agroecologia (ANA), que buscou sistematizar a experiência de 25 redes de agroecologia apoiadas pelo primeiro edital do Ecoforte, incluindo, também, uma análise da trajetória política e institucional de construção da Pnapo e do Ecoforte com base em revisão de literatura, análise de documentos e realização de entrevistas com atores-chave.

Políticas e avaliação da Pós-Graduação stricto sensu: da inserção social local à internacionalização apresenta um panorama crítico da pós-graduação brasileira, sobretudo quanto ao sistema avaliativo externo que tem sido praticado nesse nível de ensino. A obra compõe-se de sete artigos elaborados por docentes e discentes atuantes em cursos de mestrado e doutorado, bem como pesquisadores de órgãos vinculados à Educação, nos quais a comparação entre diferentes sistemas no Brasil e no exterior tece um quadro atual da pós-graduação brasileira e aponta experiências bem-sucedidas que podem incrementá-lo. Nesse sentido, constitui leitura que interessa não somente ao público acadêmico como também ao público em geral que busca acompanhar diferentes etapas e realizações no cenário da Educação nacional.

This article analyses and reflects upon a community music project that occurred in 2016 in Portugal. It involved a community of people with disabilities and a group of artists from different fields. The project’s promotors aimed to create a space in which differences were abated, social well-being was nourished and individual desires were fostered. This article endeavours to understand how artistic performance may provide opportunities for empowering less advantaged people and how it might have been achieved during this project. The reflections present in this article are based on the current literature on community music and are informed by other similar analysis of these kinds of projects. The article starts with a brief description of the project and then elaborates on the term ‘community music’ and its relationship to this project. The project made use of a mix between an art installation and an experimental instrument called Pianoscópio. This article describes this instrument in detail and analyses how it enabled the participants to express themselves to their fullest abilities. A characterisation of the participating community members follows, focusing on the core tenets of the association they were part of. After that, the article examines how the workshops took place and what transpired in the final performance, focusing specifically on the steps taken to accommodate the different disabilities of the participants. The article ends with a reflection upon these kinds of projects and the impact this one project might have had on its participants.

Neuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content.

The literature reports the benefits of multimodal interaction with the maternal voice for preterm dyads in kangaroo care. Little is known about multimodal interaction and vocal modulation between preterm mother–twin dyads. This study aims to deepen the knowledge about multimodal interaction (maternal touch, mother’s and infants’ vocalizations and infants’ gaze) between a mother and her twin preterm infants (twin 1 [female] and twin 2 [male]) during speech and humming in kangaroo care. A microanalytical case study was carried out using ELAN, PRAAT, and MAXQDA software (Version R20.4.0). Descriptive and comparative analysis was performed using SPSS software (Version V27). We observed: (1) significantly longer humming phrases to twin 2 than to twin 1 (p = 0.002), (2) significantly longer instances of maternal touch in humming than in speech to twin 1 (p = 0.000), (3) a significant increase in the pitch of maternal speech after twin 2 gazed (p = 0.002), and (4) a significant increase of pitch in humming after twin 1 vocalized (p = 0.026). This exploratory study contributes to questioning the role of maternal touch during humming in kangaroo care, as well as the mediating role of the infant’s gender and visual and vocal behavior in the tonal change of humming or speech.

Gamification involves incorporating elements of online games, such as points, leaderboards, and badges into non-game contexts, in order to improve engagement with both employees and consumers. The main point of this paper is, to sum up, what previous authors investigated in the field of Gamification. An analysis of the literature covering 50 papers from 2011 to 2016 was conducted, using Leximancer software, to determine and shape the main themes and concepts proposed in gamification papers. Answering our research question, “What guidelines may provide to future research, the key themes and concepts found in published scientific papers on gamification?”, we conclude that the researchers identified eight themes (gamification; game; use; users; business; points; engagement; learning) and twenty-eight related concepts. The present systematic review contributes to establishing possible guidelines for prospective studies, based on the analyzed papers, considering particularly their 'Conclusions' and on the 'Future research' sections, integrating game design contents in business, learning and education. Further, highlights the usefulness of Leximancer for qualitative content analysis, in this field of research.

Monthly data of abiotic variables (sea surface temperature; minimum and maximum air temperature; minimum, mean and maximum air humidity; minimum, mean and maximum atmospheric pressure; minimum, mean and maximum dew point; sea surface salinity; wind speed and direction; minimum and maximum tidal level and photosynthetically available radiation) were collected from different online repositories, all regarding the period between January 2013 and December 2017, from localities near Mar Casado Beach rocky shore, in São Paulo State southern coast, Brazil. Principal Component Analysis was performed to verify data variance and correlations among variables. Linear regression decomposition methods were applied to identify trend and seasonal patterns within the time indexed data. Deseasonalized time series were analyzed to identify structural breaks in trend patterns. Spectral analysis was applied to detrended time series. Keywords: Temporal series analysis, Ocean-atmospheric data, Rocky shore communities

A canção é, porventura, o recurso musical mais utilizado em jardins de infância e escolas do 1.º ciclo do ensino básico. Considerando que o desenvolvimento linguístico e musical destes grupos etários está numa fase sensível, este ensaio procura aprofundar a relação entre palavras e melodia numa canção. Referem-se vários estudos realizados na área da perceção e cognição musical, descrevendo-se as implicações da interação entre ambas as componentes para a identidade de uma canção e seu reconhecimento auditivo. Reconhecendo que existem diferentes formas de escutar e de aprender, comparam-se várias investigações no que respeita ao ensino de canções com palavras e sem palavras, às diferenças encontradas no seu desempenho vocal e aos procedimentos imersivo e frase-por-frase utilizados no ensino de canções. Procura-se ainda contextualizar a importância atribuída às canções sem palavras no âmbito da Teoria de Aprendizagem Musical desenvolvida por Edwin Gordon. Por fim, à luz dos estudos analisados, resumem-se os aspetos mais importantes a considerar no ensino de uma canção e em investigações futuras.

Este estudo objetiva comparar a qualidade do sono entre idosas praticantes e não praticantes de atividade física na zona sul de Teresina – Piauí. Trata-se de um estudo observacional, comparativo, transversal, descritivo e analítico, com amostra de 100 idosas, dividida em G1 e G2, formados por praticantes e não praticantes de atividade física onde foram utilizados o Índice de Qualidade de Sono Pittsburgh (IQSP) e a Escala de Sonolência de Epworth (ESE). Na análise estatística foi realizado o teste não-paramétrico de Wilcoxon-Mann-Whitney. Nos resultados pode-se observar que, as idosas ativas apresentaram menores scores no (IQSP) do que as idosas não praticantes de atividade física. Embora a má qualidade do sono tenha figurado entre 62% das idosas do G1, em contrapartida a 40% do G2, o percentual de idosas sedentárias com distúrbios do sono já instalados alcançou 42%; no G1 esse valor foi de 6%. Quanto à ocorrência da sonolência diurna excessiva averiguou-se que dentro do G1 52% das idosas apresentaram nível de normalidade, enquanto que, no G2 esta proporção caiu para 36%.

Mobile payments still remain essentially an emerging technology, seeking to fill the gap between the envisioned potential and widespread usage. In this paper, we present an integrated mobile service solution based on the near field communication (NFC) protocol that was developed under a research project called MobiPag. The most distinctive characteristic of Mobipag is its open architectural model that allows multiple partners to become part of the payment value-chain and create solutions that complement payments in many unexpected ways. We describe the Mobipag architecture and how it has been used to support a mobile payment trial. We identify a set of design lessons resulting from usage experiences associated with real-world payment situations with NFC-enabled mobile phones. Based on results from this trial, we identify a number of challenges and guidelines that may help to shape future versions of NFC-based payment systems. In particular, we highlight key challenges for the initial phases of payment deployments, where it is essential to focus on scenarios that can be identified as more feasible for early adoption. We also have identified a fundamental trade-off between the flexibility supported by the Mobipag solution and the respective implications for the payment process, particularly on the users’ mental model.

Anomalies on road pavement cause discomfort to drivers and passengers, and may cause mechanical failure or even accidents. Governments spend millions of Euros every year on road maintenance, often causing traffic jams and congestion on urban roads on a daily basis. This paper analyses the difference between the deployment of a road anomalies detection and identification system in a “conditioned” and a real world setup, where the system performed worse compared to the “conditioned” setup. It also presents a system performance analysis based on the analysis of the training data sets; on the analysis of the attributes complexity, through the application of PCA techniques; and on the analysis of the attributes in the context of each anomaly type, using acceleration standard deviation attributes to observe how different anomalies classes are distributed in the Cartesian coordinates system. Overall, in this paper, we describe the main insights on road anomalies detection challenges to support the design and deployment of a new iteration of our system towards the deployment of a road anomaly detection service to provide information about roads condition to drivers and government entities.

In breast cancer, the Human Epidermal growth factor Receptor 2 (HER2) is associated with worst prognosis in all stages of the disease, and it is specifically targeted by a monoclonal antibody (trastuzumab). Nevertheless, the different response rates observed have increased the search for better predictive markers. Elevated levels of the extracellular domain of HER2/neu in the serum have been associated with the clinical outcome of breast cancer patients.The authors proposed to analyze serum HER2/neu in breast cancer patients, under treatment with trastuzumab, in monotherapy or associated with another systemic therapy, either in adjuvant or metastatic setting, in order to evaluate its role as prognostic, predictive and monitoring factor. From March 2007 to May 2008, 173 serum samples from 43 patients were analysed, corresponding to the beginning of the treatment of trastuzumab and 3/3 months afterwards. Serum HER2/neu levels were measured with ADVIA Centaur(®) immunoassay and levels > 15 ng/mL were defined as elevated, according to previous reports.Elevated baseline serum levels were found to be associated with a worst overall survival (p = 0,003). In the metastatic setting, baseline HER2/neu serum levels were not associated with response rate to trastuzumab. However, when we analyzed the variations in HER2/neu serum levels between the response evaluation date and the first measurement, we observed that patients whose serum levels declined showed significantly higher objective response compared with patients with stable or elevated serum values (p = 0,001). Moreover, monitoring early changes in serum levels (three months) could also predict the probability of response to trastuzumab-based treatment (p = 0,007).The use of this predictive potential could not only focus and tailor treatment individually but also adapt to economic needs.

The development of biotechnology drugs represents one of the great advances in medical therapy and it was observed an exponential growth in its use. The resource to these drugs in Oncology and Hematology is no exception and it soon became an essential element of an integrated and directed therapy strategy. The expiry of the first biotechnology drugs patents has opened the door for the development and marketing of biosimilars, which entry in the Portuguese market was recently approved. This article was built on the analysis of the available state-of-the-art information on biotechnology drugs, biosimilars and current legislation and it expresses the opinion of Oncology and Hematology experts about the substituition of biological drugs by biosimilars in clinical practice.

Neutropenia and febrile neutropenia are common consequences of some cytotoxic chemotherapy regimens. This situation leads to modifications of the therapeutic regimen, conducting to either dose reduction or cycle delays. Granulocyte colony stimulating factors are commonly used to minimize chemotherapy cytotoxic effect on the granulocytic series. The objective of this study is to assess the available evidence in what concerns the efficacy and safety of granulocyte colony stimulating factors, in several settings of their use. An extensive bibliographic review was performed, including clinical trials, observational studies, systematic reviews, and international guidelines for neutropenia prophylaxis, which aims to establish recommendations on their use, in adequacy to the National reality.