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31 results on '"Held, Melissa"'

4. Effect of the addition of a mental health specialist for evaluation of undiagnosed patients in centres for rare diseases (ZSE-DUO): a prospective, controlled trial with a two-phase cohort design

Author

Akkaya, Federica, Babka, Christine, Bannert, Lisa, Bärsch-Michelmann, Anja, Böhm, Leonie, Brinkmann, Folke, Bullinger, Monika, Cario, Holger, de Greck, Moritz, Debatin, Klaus-Michael, Dillmann-Jehn, Katrin, Eymann, Jutta, Frisch, Julia, Glode, Anja, Gödecke, Vega, Grasemann, Corinna, Grauer, Eva, Haas, Astrid, Haisch, Lea, Isabell, Heinrich, Held, Melissa, Hennermann, Julia, Herpertz, Stephan, Herrmann-Werner, Anne, Hett, Julian, Heuschmann, Peter, Hilbig, Bettina, Holthöfer, Laura, Imhof, Christiane, Junne, Florian, Kassubek, Jan, Koschitzki, Kevin-Thomas, Krassort, Heike, Kropff, Birgit, Kuhn, Julia, Latzko, Philipp, Loew, Thomas, Ludolph, Albert C., Meyer, Torsten, Meyer dos Santos, Isabell, Mohnike, Klaus, Monninger, Martina, Mücke, Martin, Müller, Susanne, Musacchio, Thomas, Nießen, Margret, Nöhre, Mariel, Ott, Stephan, Petermann-Meyer, Andrea, Pfeifer-Duck, Christina, Piduhn, Lea-Sophie, Rampp, Carina, Rieß, Olaf, Schaubert, Kristina, Schmidt, Annika, Schneider, Simone, Schoels, Ludger, Schwalba, Martina, Selig, Udo, Sroka, Alexandra, Steinbüchel, Toni, Stösser, Sebastian, Suchant, Steffi, Ungethüm, Kathrin, Vogel, Matthias, Volk, Daniela, Vollmuth, Christoph, Volnov, Solange, Wagner, Thomas O.F., Walter, Sabrina, Warrings, Bodo, Zajt, Kamil, Zenker, Karola, Zhang, David, Zipfel, Stephan, Hebestreit, Helge, Lapstich, Anne-Marie, Brandstetter, Lilly, Krauth, Christian, Deckert, Jürgen, Haas, Kirsten, Pfister, Lisa, Witt, Stefanie, Schippers, Christopher, Dieris-Hirche, Jan, Maisch, Tim, Tüscher, Oliver, Bârlescu, Lavinia Aurelia, Berger, Alexandra, Berneburg, Mark, Britz, Vanessa, Deibele, Anna, Graeßner, Holm, Gündel, Harald, Heuft, Gereon, Lücke, Thomas, Mundlos, Christine, Quitmann, Julia Hannah, Rutsch, Frank, Schubert, Katharina, Schulz, Jörg B., Schweiger, Susann, Zeidler, Cornelia, Zeltner, Lena Margarete, de Zwaan, Martina, Bârlescu, Lavinia, Quitmann, Julia, Schulz, Jörg Bernhard, and Zeltner, Lena

Published
2023
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9. Tafamidis for cardiac transthyretin amyloidosis: application in a real-world setting in Germany

Author

Morbach, Caroline, primary, Papagianni, Aikaterini, additional, Ihne-Schubert, Sandra, additional, Cejka, Vladimir, additional, Steinhardt, Maximilian, additional, Fette, Georg, additional, Held, Melissa, additional, Geier, Andreas, additional, Einsele, Hermann, additional, Frantz, Stefan, additional, Knop, Stefan, additional, Sommer, Claudia, additional, and Störk, Stefan, additional

Published
2023
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14. One Year into the COVID-19 Pandemic: an Update on Medical Student Experiences and Well-being.

Author

Dagher, Tanios, Alkureishi, Maria A., Vayani, Omar R., Chalmers, Kristen, Zhu, Mengqi, Woodruff, James N., Lee, Wei Wei, for the Medical Student Well-being Research Consortium, Burrows, Jason, Fang, Yuan, Fiorillo, Megan, Germain, Lauren J., Goodman, Elizabeth, Held, Melissa, Idrizi, Haneme, Janes, Brady J., Krawiec, Conrad, McDermott, Allyson, Myint, Myo Thwin, and Nanavati, Kaushal B.

Subjects
MEDICAL students, COVID-19 pandemic, STUDENT well-being, HISPANIC American students, MASLACH Burnout Inventory, HISPANIC Americans
Abstract

In Spring 2021, Asian, Hispanic, and Black students were more likely to experience burnout compared to White students (OR=1.28 (0.96, 1.72), OR=1.15 (0.78, 1.68), OR=1.14 (0.71, 1.84) respectively). While M2s and M3s reported the highest stress and burnout, M1s who entered school during the pandemic had the highest loneliness scores. In this follow-up study, we aim to (1) compare student burnout, stress, and loneliness in Spring 2020 vs. 2021 and (2) explore student experiences in Spring 2021. [Extracted from the article]

Published
2023
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18. Systemic expression of cytokines in painful and painless polyneuropathies

Author

Langjahr [verh. Held], Melissa

Subjects
Polyneuropathie, Genexpression, ddc:610, Cytokine
Abstract

Die Pathophysiologie der PNP wie auch die Entstehung der oft assoziierten neuropathischen Schmerzen ist unklar. Gleichzeitig gibt es bislang keine geeigneten Biomarker, die die oft komplizierte Differentialdiagnose vereinfachen können. Einige Tiermodelle und klinische Studien lieferten bereits Hinweise auf die entscheidende Rolle pro- und anti-inflammatorischer Zytokine in diesen Prozessen. Ziel unserer Studie war es, die systemische Genexpression pro- und anti-inflammatorischer Zytokine in einer großen Kohorte von Patienten mit PNP verschiedener Ätiologie zu charakterisieren. Insgesamt konnten 111 PNP-Patienten und 38 gesunde Kontrollpersonen prospektiv rekrutiert werden. Nach Isolation von PBMC aus Blutproben von 97 Patienten wurde die Genexpression der pro-inflammatorischen Zytokine TNF, IL1, IL2, IL6, IL8 und der anti-inflammatorischen Zytokine IL4 und IL10 mittels qRT-PCR bestimmt. Bei 47 Patienten und 12 Kontrollen wurde zudem die IL6-, IL-8- und TNF-Zytokinproduktion von PBMC in vitro nach Stimulation durch LPS mittels ELISA untersucht. Hauptbefund war ein pro-inflammatorisches Zytokinprofil der PNP-Patienten mit höherer Genexpression von IL1, IL2, IL8 und TNF im Vergleich zu den gesunden Kontrollen. Im Falle der entzündlichen Neuropathien konnte zudem eine niedrigere Genexpression von IL10 im Vergleich zu Gesunden nachgewiesen werden. Sowohl schmerzhafte als auch schmerzlose Verlaufsformen wiesen ein pro-inflammatorisches Zytokingenexpressionsprofil im Vergleich zu Gesunden auf, das bei schmerzhaften PNP deutlich mehr beteiligte pro-inflammatorische Zytokine umfasste; relevante Unterschiede zwischen den PNP-Patienten mit und ohne Schmerz sowie der diagnostischen Subgruppen fanden sich nicht. Eine niedrigere Stimulationsschwelle der PBMC lag bei PNP-Patienten im Vergleich zu Gesunden nicht vor. Insgesamt erscheint die Rolle einzelner Zytokine als systemische Biomarker für die Differenzierung verschiedener PNP-Formen bzw. bezüglich neuropathischen Schmerzes aufgrund einer niedrigen Spezifität deutlich eingeschränkt. Dennoch sprechen unsere Ergebnisse für eine mögliche Rolle eines pro-inflammatorischen Milieus bei der Entstehung bzw. des Verlaufes verschiedener entzündlicher und nicht-entzündlicher Neuropathien und neuropathischen Schmerzes., Distinct cytokine expression patterns have been reported in biomaterial of patients with polyneuropathies (PNP). We investigated gene expression profiles of pro- and anti-inflammatory cytokines in peripheral blood mononuclear cells (PBMC) of patients with neuropathies of different etiologies. We prospectively studied 111 patients with neuropathies and compared data between diagnostic subgroups and healthy controls. Gene expression of a panel of pro- and anti-inflammatory cytokines was analyzed (interleukin-1 [IL-1], IL-2, IL-6, IL-8, and tumor necrosis factor-alpha [TNF], IL-4 and IL-10) in PBMC samples of 97 patients and 38 healthy controls. Furthermore, protein levels of IL-6, IL-8, and TNF were measured in supernatant of PBMC stimulated with lipopolysaccharide (LPS). PNP were associated with higher PBMC gene expression of IL-1 (p

Published
2018

25. Effectiveness of Monovalent and Pentavalent Rotavirus Vaccine

Author

Cortese, Margaret M., primary, Immergluck, Lilly Cheng, additional, Held, Melissa, additional, Jain, Shabnam, additional, Chan, Trisha, additional, Grizas, Alexandra P., additional, Khizer, Saadia, additional, Barrett, Carol, additional, Quaye, Osbourne, additional, Mijatovic-Rustempasic, Slavica, additional, Gautam, Rashi, additional, Bowen, Michael D., additional, Moore, Jessica, additional, Tate, Jacqueline E., additional, Parashar, Umesh D., additional, and Vázquez, Marietta, additional

Published
2013
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28. Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state

Author

Held, Melissa R., Begier, Elizabeth M., Beardsley, Diana S., Browne, Frederick A., Martinello, Richard A., Baltimore, Robert S., McDonald, L. Clifford, Jensen, Bette, Hadler, James L., and Dembry, Louise-Marie

Subjects
Electrophoresis -- Analysis, Sepsis -- Risk factors, Sepsis -- Care and treatment
Abstract

We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important for ensuring safe delivery of compounded medications to patients in all settings, including those outside health care facilities. KEYWORDS. Burkholderia cepacia, compounding, contamination, antibiotic-lock solution, sepsis. PEDIATRICS 2006;118:e212-e215. URL: www.pediatrics.org/cgi/doi/10.1542/peds.2005-2617

Published
2006

30. The Didactic Makeover: Keep it Short, Active, Relevant.

Author

Rideout, Molly, Held, Melissa, and Volpe Holmes, Alison

Subjects
*ALTERNATIVE education, *LEARNING strategies, *MEDICAL students, *TEACHING methods, *ACCESS to information, STUDY & teaching of medicine
Abstract

The article discusses the evolution in medical student education as of July 2016. Topics discussed include the immediate access of students to instant information online which allows teaching physicians to develop new ways of delivering content to students, the partnership between Stanford University and Khan Academy in developing the program called Stanford Medicine Interactive Learning Initiatives, and the Council on Medical Student Education in Pediatrics series.

Published
2016
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31. Dual Guidance Structure for Evaluation of Patients with Unclear Diagnosis in Centers for Rare Diseases (ZSE-DUO): Study Protocol for a Controlled Multi-center Cohort Study

Author

Helge, Hebestreit, Cornelia, Zeidler, Christopher, Schippers, Martina, de Zwaan, Jürgen, Deckert, Peter, Heuschmann, Christian, Krauth, Monika, Bullinger, Alexandra, Berger, Mark, Berneburg, Lilly, Brandstetter, Anna, Deibele, Jan, Dieris-Hirche, Holm, Graessner, Harald, Gündel, Stephan, Herpertz, Gereon, Heuft, Anne-Marie, Lapstich, Thomas, Lücke, Tim, Maisch, Christine, Mundlos, Andrea, Petermann-Meyer, Susanne, Müller, Stephan, Ott, Lisa, Pfister, Julia, Quitmann, Marcel, Romanos, Frank, Rutsch, Kristina, Schaubert, Katharina, Schubert, Jörg B, Schulz, Susann, Schweiger, Oliver, Tüscher, Kathrin, Ungethüm, Thomas O F, Wagner, Kirsten, Haas, Stephan, Zipfel, Rampp, Carina, Richter, Antonia, Rieß, Olaf, Schmidt, Annika, Schneider, Simone, Schoels, Ludger, Schwalba, Martina, Selig, Udo, Spangenberger, Astrid, Sroka, Alexandra, Steinbüchel, Toni, Stösser, Sebastian, Suchant, Steffi, Vogel, Matthias, Volk, Daniela, Vollmuth, Christoph, Volnov, Solange, Walter, Sabrina, Warrings, Bodo, Weiler, Christine, Witt, Stefanie, Zajt, Kamil Kajetan, Zeltner, Lena, Zenker, Karola, Zhang, Kailun David, Zipfel, Stephan, Akkaya, Federica, Babka, Christine, Bârlescu, Lavinia, Bärsch-Michelmann, Anja, Bergbreiter, Astrid, Blömeke, Janika, Böhm, Leonie, Böttger, Benita, Braun, Birgit, Brinkmann, Folke, Britz, Vanessa, Cario, Holger, Celiker, Melisa, de Greck, Moritz, Debatin, Klaus-Michael, Dillmann-Jehn, Katrin, Ertl, Max, Ettinger, Monika, Eymann, Jutta, Frommer, Jörg, Gabrian, Martina, Glode, Anja, Gödecke, Vega, Grasemann, Corinna, Grauer, Eva, Greger, Helmut, Haas, Astrid, Haase, Martina, Haisch, Lea, Heinrich, Isabel, Held, Melissa, Hennermann, Julia, Herrmann-Werner, Anne, Hett, Julian, Hilbig, Bettina, Holthöfer, Laura, Imhof, Christiane, Jacob, Titus, Junne, Florian, Karl, Stefanie, Kassubek, Jan, Kick, Lisa, Koschitzki, Kevin-Thomas, Krassort, Heike, Kratz, Christian, Kristensen, Kaja, Kropff, Birgit, Kuhn, Julia, Latzko, Philipp, Loew, Thomas, Lorenz, Delia, Ludolph, Albert C., Dos Santos, Isabell Meyer, Meyer, Torsten, Mohnike, Klaus, Monninger, Martina, Musacchio, Thomas, Nanciu, Amalia Nicole, Nießen, Margret, Nöhre, Mariell, Papagianni, Aikaterini, Pfeifer-Duck, Christina, and Piduhn, Lea-Sophie

Subjects
Protocol (science), medicine.medical_specialty, ddc:618, business.industry, General Medicine, DUAL (cognitive architecture), Cohort Studies, Diagnosis, Differential, Rare Diseases, Treatment Outcome, Quality of Life, Humans, Multicenter Studies as Topic, Medicine, Pharmacology (medical), Medical physics, Center (algebra and category theory), Prospective Studies, Child, business, Genetics (clinical), Cohort study
Abstract

Orphanet journal of rare diseases : OJRD 17(1), 47 (2022). doi:10.1186/s13023-022-02176-1, Published by BioMed Central, London

Published
2021

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